locus-tag	class	description
G8D99_RS00010	COG0592	DNA-directed DNA polymerase activity
G8D99_RS00020	COG0187	DNA topoisomerase II activity
G8D99_RS00045	COG0596	Alpha beta hydrolase
G8D99_RS00050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G8D99_RS00055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8D99_RS00060	COG0488	(ABC) transporter
G8D99_RS00075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G8D99_RS00095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G8D99_RS00225	COG1047	Peptidyl-prolyl cis-trans
G8D99_RS00230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G8D99_RS00235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G8D99_RS00240	COG0196	riboflavin kinase activity
G8D99_RS00255	COG1309	transcriptional regulator
G8D99_RS00260	COG1116	anion transmembrane transporter activity
G8D99_RS00265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D99_RS00270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8D99_RS00275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D99_RS00280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D99_RS00285	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G8D99_RS00285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G8D99_RS00315	COG2814	Major facilitator Superfamily
G8D99_RS00330	COG2818	Glycosylase
G8D99_RS00345	COG1194	a g-specific adenine glycosylase
G8D99_RS00360	COG5487	UPF0391 membrane protein
G8D99_RS00365	COG2983	Belongs to the UPF0260 family
G8D99_RS00370	COG2133	pyrroloquinoline quinone binding
G8D99_RS00375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8D99_RS00390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8D99_RS00395	COG1335	isochorismatase
G8D99_RS00400	COG0385	Bile acid
G8D99_RS00405	COG1683	Conserved Protein
G8D99_RS00410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8D99_RS00420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8D99_RS00425	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G8D99_RS00435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G8D99_RS00450	COG0560	Phosphoserine phosphatase
G8D99_RS00450	COG3830	Belongs to the UPF0237 family
G8D99_RS00515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8D99_RS00535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D99_RS00540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D99_RS00550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8D99_RS00555	COG0534	Mate efflux family protein
G8D99_RS00560	COG0436	Aminotransferase
G8D99_RS00565	COG2733	membrane
G8D99_RS00580	COG2918	glutathione biosynthetic process
G8D99_RS00585	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G8D99_RS00600	COG3150	esterase
G8D99_RS00650	COG4266	Belongs to the allantoicase family
G8D99_RS00655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8D99_RS00660	COG1247	-acetyltransferase
G8D99_RS00695	COG0666	response to abiotic stimulus
G8D99_RS00695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G8D99_RS00710	COG2199	diguanylate cyclase activity
G8D99_RS00710	COG2203	Gaf domain
G8D99_RS00725	COG1393	Belongs to the ArsC family
G8D99_RS00730	COG0708	Exodeoxyribonuclease III
G8D99_RS00735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G8D99_RS00750	COG0189	ligase activity
G8D99_RS00760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G8D99_RS00765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8D99_RS00775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G8D99_RS00790	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G8D99_RS00815	COG2119	membrane
G8D99_RS00820	COG0426	domain, Protein
G8D99_RS00820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8D99_RS00835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8D99_RS00845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8D99_RS00870	COG1902	pentaerythritol trinitrate reductase activity
G8D99_RS00875	COG1519	Transferase
G8D99_RS00880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8D99_RS00890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8D99_RS00910	COG0431	NADPH-dependent FMN reductase
G8D99_RS00925	COG0784	Response regulator, receiver
G8D99_RS00925	COG2205	protein histidine kinase activity
G8D99_RS00930	COG3162	membrane
G8D99_RS00950	COG3706	GGDEF domain
G8D99_RS00960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8D99_RS00965	COG3136	membrane protein required for alginate biosynthesis
G8D99_RS00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8D99_RS00980	COG2814	Major facilitator Superfamily
G8D99_RS00995	COG0583	DNA-binding transcription factor activity
G8D99_RS01000	COG1335	isochorismatase
G8D99_RS01035	COG3158	transport of potassium into the cell
G8D99_RS01055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8D99_RS01120	COG0697	spore germination
G8D99_RS01145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G8D99_RS01185	COG0427	acetyl-CoA hydrolase
G8D99_RS01195	COG0745	RESPONSE REGULATOR receiver
G8D99_RS01210	COG0659	secondary active sulfate transmembrane transporter activity
G8D99_RS01220	COG4221	oxidoreductase activity
G8D99_RS01225	COG2873	o-acetylhomoserine
G8D99_RS01230	COG0488	(ABC) transporter
G8D99_RS01265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8D99_RS01270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8D99_RS01295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G8D99_RS01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8D99_RS01305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8D99_RS01310	COG2226	methyltransferase
G8D99_RS01345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G8D99_RS01360	COG0070	glutamate synthase
G8D99_RS01360	COG0067	glutamate synthase
G8D99_RS01360	COG0069	glutamate synthase activity
G8D99_RS01365	COG0493	'glutamate synthase
G8D99_RS01375	COG0307	riboflavin synthase, alpha
G8D99_RS01385	COG2212	antiporter activity
G8D99_RS01395	COG0651	ATP synthesis coupled electron transport
G8D99_RS01400	COG1006	Multisubunit Na H antiporter MnhC subunit
G8D99_RS01405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G8D99_RS01405	COG2111	Na H antiporter
G8D99_RS01420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G8D99_RS01435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8D99_RS01465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G8D99_RS01470	COG1074	ATP-dependent DNA helicase activity
G8D99_RS01475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8D99_RS01490	COG1185	polyribonucleotide nucleotidyltransferase activity
G8D99_RS01495	COG0598	Magnesium transport protein CorA
G8D99_RS01500	COG2841	Protein conserved in bacteria
G8D99_RS01515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G8D99_RS01525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G8D99_RS01545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G8D99_RS01550	COG4535	Mg2 and Co2 transporter CorC
G8D99_RS01560	COG0425	Belongs to the sulfur carrier protein TusA family
G8D99_RS01620	COG0644	oxidoreductase
G8D99_RS01620	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G8D99_RS01630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8D99_RS01645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8D99_RS01650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G8D99_RS01675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G8D99_RS01680	COG0254	rRNA binding
G8D99_RS01685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8D99_RS01690	COG0534	Mate efflux family protein
G8D99_RS01700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8D99_RS01715	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS01740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G8D99_RS01750	COG0513	Belongs to the DEAD box helicase family
G8D99_RS01755	COG1127	ABC transporter
G8D99_RS01760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G8D99_RS01765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G8D99_RS01780	COG0598	Magnesium transport protein CorA
G8D99_RS01795	COG1040	competence protein
G8D99_RS01800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8D99_RS01805	COG2937	Belongs to the GPAT DAPAT family
G8D99_RS01810	COG1946	Acyl-CoA thioesterase
G8D99_RS01815	COG1301	dicarboxylic acid transport
G8D99_RS01830	COG4993	Dehydrogenase
G8D99_RS01835	COG1959	2 iron, 2 sulfur cluster binding
G8D99_RS01840	COG1017	nitric oxide dioxygenase activity
G8D99_RS01840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8D99_RS01845	COG0433	COG0433 Predicted ATPase
G8D99_RS01850	COG0626	cystathionine gamma-synthase activity
G8D99_RS01860	COG0051	transcription antitermination factor activity, RNA binding
G8D99_RS01870	COG0088	Forms part of the polypeptide exit tunnel
G8D99_RS01885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G8D99_RS01915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G8D99_RS01930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G8D99_RS01935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G8D99_RS01940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G8D99_RS01950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G8D99_RS01960	COG0200	Binds to the 23S rRNA
G8D99_RS01975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G8D99_RS01985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G8D99_RS01990	COG0202	RNA polymerase activity
G8D99_RS01995	COG0203	ribosomal protein L17
G8D99_RS02000	COG2072	flavoprotein involved in K transport
G8D99_RS02005	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS02010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G8D99_RS02040	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G8D99_RS02045	COG0339	signal peptide processing
G8D99_RS02050	COG0557	exoribonuclease II activity
G8D99_RS02085	COG0179	Fumarylacetoacetate (FAA) hydrolase
G8D99_RS02090	COG1295	ribonuclease BN
G8D99_RS02105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D99_RS02135	COG0668	transmembrane transport
G8D99_RS02145	COG1702	phosphate starvation-inducible protein PhoH
G8D99_RS02150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G8D99_RS02155	COG0741	lytic transglycosylase activity
G8D99_RS02155	COG0739	heme binding
G8D99_RS02155	COG1196	nuclear chromosome segregation
G8D99_RS02190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G8D99_RS02195	COG1183	phosphatidylcholine synthase activity
G8D99_RS02260	COG1607	acyl-coa hydrolase
G8D99_RS02280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8D99_RS02285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D99_RS02285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G8D99_RS02295	COG2350	Protein conserved in bacteria
G8D99_RS02305	COG0613	PHP domain protein
G8D99_RS02310	COG3781	membrane
G8D99_RS02315	COG2003	Belongs to the UPF0758 family
G8D99_RS02320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8D99_RS02330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G8D99_RS02340	COG1162	GTPase activity
G8D99_RS02345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G8D99_RS02365	COG3501	Rhs element vgr protein
G8D99_RS02380	COG3209	COG3209 Rhs family protein
G8D99_RS02415	COG1538	Outer membrane efflux protein
G8D99_RS02420	COG0577	efflux transmembrane transporter activity
G8D99_RS02420	COG1136	(ABC) transporter
G8D99_RS02425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D99_RS02450	COG0028	Belongs to the TPP enzyme family
G8D99_RS02495	COG1426	Protein conserved in bacteria
G8D99_RS02515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8D99_RS02535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8D99_RS02545	COG1862	Preprotein translocase
G8D99_RS02560	COG1704	LemA family
G8D99_RS02575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G8D99_RS02585	COG0784	Response regulator, receiver
G8D99_RS02585	COG2205	protein histidine kinase activity
G8D99_RS02585	COG5002	protein histidine kinase activity
G8D99_RS02590	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G8D99_RS02645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G8D99_RS02675	COG3223	Belongs to the PsiE family
G8D99_RS02685	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS02690	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS02700	COG2205	protein histidine kinase activity
G8D99_RS02705	COG0745	RESPONSE REGULATOR receiver
G8D99_RS02710	COG1113	amino acid transport
G8D99_RS02720	COG2315	Protein conserved in bacteria
G8D99_RS02730	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G8D99_RS02745	COG2096	Adenosyltransferase
G8D99_RS02750	COG4206	TonB-dependent receptor
G8D99_RS02780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8D99_RS02790	COG0183	Belongs to the thiolase family
G8D99_RS02810	COG0833	amino acid
G8D99_RS02820	COG2233	PERMEase
G8D99_RS02830	COG1970	mechanosensitive ion channel activity
G8D99_RS02855	COG3659	wide pore channel activity
G8D99_RS02860	COG4772	TonB-dependent receptor
G8D99_RS02865	COG1902	pentaerythritol trinitrate reductase activity
G8D99_RS02885	COG1953	Uracil, thiamine, allantoin
G8D99_RS02910	COG0354	folic acid binding
G8D99_RS02950	COG0564	pseudouridine synthase activity
G8D99_RS02965	COG0628	permease
G8D99_RS02970	COG2824	Alkylphosphonate utilization operon protein PhnA
G8D99_RS02990	COG0494	nUDIX hydrolase
G8D99_RS03010	COG4137	Cytochrome C assembly protein
G8D99_RS03015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8D99_RS03020	COG3545	Serine hydrolase
G8D99_RS03030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G8D99_RS03040	COG0730	response to heat
G8D99_RS03050	COG1196	nuclear chromosome segregation
G8D99_RS03060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G8D99_RS03065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8D99_RS03080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8D99_RS03085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
G8D99_RS03090	COG2193	ferroxidase activity
G8D99_RS03095	COG0596	Alpha beta hydrolase
G8D99_RS03095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8D99_RS03095	COG2226	methyltransferase
G8D99_RS03105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G8D99_RS03110	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G8D99_RS03115	COG0009	L-threonylcarbamoyladenylate synthase
G8D99_RS03120	COG3101	peptidyl-lysine hydroxylation
G8D99_RS03125	COG1399	metal-binding, possibly nucleic acid-binding protein
G8D99_RS03130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G8D99_RS03145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G8D99_RS03150	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS03160	COG1652	LysM domain
G8D99_RS03270	COG4372	Transposase
G8D99_RS03285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G8D99_RS03295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8D99_RS03305	COG0745	RESPONSE REGULATOR receiver
G8D99_RS03310	COG2205	protein histidine kinase activity
G8D99_RS03340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G8D99_RS03355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8D99_RS03365	COG0713	ATP synthesis coupled electron transport
G8D99_RS03375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8D99_RS03385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G8D99_RS03405	COG0583	DNA-binding transcription factor activity
G8D99_RS03425	COG0668	transmembrane transport
G8D99_RS03440	COG2081	HI0933 family
G8D99_RS03495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8D99_RS03495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8D99_RS03525	COG0489	protein tyrosine kinase activity
G8D99_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D99_RS03605	COG0840	transmembrane signaling receptor activity
G8D99_RS03610	COG0643	Histidine kinase
G8D99_RS03610	COG2198	Histidine kinase
G8D99_RS03625	COG5510	response to toxic substance
G8D99_RS03635	COG2832	Protein of unknown function (DUF454)
G8D99_RS03695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G8D99_RS03705	COG1289	transmembrane transporter activity
G8D99_RS03710	COG2814	Major facilitator Superfamily
G8D99_RS03725	COG0786	glutamate:sodium symporter activity
G8D99_RS03730	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8D99_RS03740	COG1607	acyl-coa hydrolase
G8D99_RS03755	COG0523	cobalamin synthesis protein
G8D99_RS03760	COG4681	YaeQ
G8D99_RS03775	COG0726	polysaccharide deacetylase
G8D99_RS03775	COG1649	PFAM Uncharacterised BCR, COG1649
G8D99_RS03780	COG1215	transferase activity, transferring glycosyl groups
G8D99_RS03795	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G8D99_RS03840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8D99_RS03850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8D99_RS03855	COG1077	Cell shape determining protein MreB Mrl
G8D99_RS03860	COG1792	Involved in formation and maintenance of cell shape
G8D99_RS03870	COG0424	maF-like protein
G8D99_RS03875	COG1530	ribonuclease E activity
G8D99_RS03885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8D99_RS03895	COG0560	Phosphoserine phosphatase
G8D99_RS03920	COG1113	amino acid transport
G8D99_RS03925	COG2828	Protein conserved in bacteria
G8D99_RS03930	COG3300	MHYT domain
G8D99_RS03930	COG5001	Diguanylate cyclase
G8D99_RS03935	COG0142	geranyltranstransferase activity
G8D99_RS03940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8D99_RS03955	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8D99_RS03975	COG0004	ammonium transporteR
G8D99_RS03990	COG2323	membrane
G8D99_RS04000	COG2851	Citrate transporter
G8D99_RS04005	COG1253	flavin adenine dinucleotide binding
G8D99_RS04020	COG3015	lipoprotein NlpE involved in copper resistance
G8D99_RS04025	COG0204	Acyl-transferase
G8D99_RS04040	COG2268	Band 7 protein
G8D99_RS04055	COG2354	Protein conserved in bacteria
G8D99_RS04060	COG2321	neutral zinc metallopeptidase
G8D99_RS04065	COG0025	NhaP-type Na H and K H
G8D99_RS04110	COG0589	response to stress
G8D99_RS04125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G8D99_RS04130	COG0505	Belongs to the CarA family
G8D99_RS04155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8D99_RS04160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G8D99_RS04195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G8D99_RS04215	COG1597	lipid kinase activity
G8D99_RS04250	COG0584	glycerophosphoryl diester phosphodiesterase
G8D99_RS04270	COG0741	lytic transglycosylase activity
G8D99_RS04270	COG0739	heme binding
G8D99_RS04270	COG1196	nuclear chromosome segregation
G8D99_RS04275	COG0037	tRNA processing
G8D99_RS04285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G8D99_RS04290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8D99_RS04300	COG1741	Belongs to the pirin family
G8D99_RS04315	COG3739	integral membrane protein
G8D99_RS04335	COG3706	GGDEF domain
G8D99_RS04345	COG0302	gtp cyclohydrolase
G8D99_RS04380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8D99_RS04385	COG0512	Glutamine amidotransferase of anthranilate synthase
G8D99_RS04400	COG0174	glutamine synthetase
G8D99_RS04410	COG3161	chorismate lyase activity
G8D99_RS04415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G8D99_RS04450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8D99_RS04455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8D99_RS04460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8D99_RS04480	COG1115	amino acid carrier protein
G8D99_RS04485	COG1113	amino acid transport
G8D99_RS04495	COG0019	diaminopimelate decarboxylase activity
G8D99_RS04500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G8D99_RS04510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G8D99_RS04525	COG1280	lysine exporter protein (LysE YggA)
G8D99_RS04555	COG1301	dicarboxylic acid transport
G8D99_RS04570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D99_RS04600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8D99_RS04605	COG0418	dihydroorotase activity
G8D99_RS04610	COG4251	negative regulation of phosphorylation
G8D99_RS04610	COG2203	Gaf domain
G8D99_RS04610	COG3706	GGDEF domain
G8D99_RS04610	COG5001	Diguanylate cyclase
G8D99_RS04615	COG3706	GGDEF domain
G8D99_RS04615	COG4251	negative regulation of phosphorylation
G8D99_RS04615	COG2203	Gaf domain
G8D99_RS04615	COG5001	Diguanylate cyclase
G8D99_RS04625	COG1620	l-lactate permease
G8D99_RS04630	COG2186	Transcriptional regulator
G8D99_RS04640	COG0277	FAD linked oxidase domain protein
G8D99_RS04650	COG1902	pentaerythritol trinitrate reductase activity
G8D99_RS04650	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8D99_RS04660	COG2995	paraquat-inducible protein a
G8D99_RS04665	COG2995	paraquat-inducible protein a
G8D99_RS04670	COG3008	intermembrane lipid transfer
G8D99_RS04670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G8D99_RS04685	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G8D99_RS04695	COG0281	malic enzyme
G8D99_RS04695	COG0280	phosphate acetyltransferase
G8D99_RS04705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8D99_RS04710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G8D99_RS04715	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G8D99_RS04735	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS04740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G8D99_RS04750	COG1289	transmembrane transporter activity
G8D99_RS04755	COG1289	transmembrane transporter activity
G8D99_RS04765	COG0583	DNA-binding transcription factor activity
G8D99_RS04790	COG0052	Belongs to the universal ribosomal protein uS2 family
G8D99_RS04815	COG2951	lytic endotransglycosylase activity
G8D99_RS04820	COG0772	Belongs to the SEDS family
G8D99_RS04835	COG0842	Transport permease protein
G8D99_RS04840	COG1131	(ABC) transporter
G8D99_RS04850	COG1113	amino acid transport
G8D99_RS04885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8D99_RS04905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8D99_RS04925	COG0823	Involved in the tonB-independent uptake of proteins
G8D99_RS04945	COG0824	Thioesterase
G8D99_RS04960	COG2255	four-way junction helicase activity
G8D99_RS04975	COG0616	signal peptide processing
G8D99_RS04995	COG0482	sulfurtransferase activity
G8D99_RS05015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G8D99_RS05020	COG1686	Belongs to the peptidase S11 family
G8D99_RS05040	COG4942	peptidase
G8D99_RS05040	COG1388	LysM domain
G8D99_RS05050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8D99_RS05055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G8D99_RS05060	COG1067	ATP-dependent peptidase activity
G8D99_RS05095	COG1509	lysine 2,3-aminomutase activity
G8D99_RS05100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G8D99_RS05105	COG1966	Carbon starvation protein
G8D99_RS05120	COG0714	Associated with various cellular activities
G8D99_RS05160	COG1944	ATP diphosphatase activity
G8D99_RS05165	COG2252	PERMEase
G8D99_RS05170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G8D99_RS05180	COG3038	cytochrome b561
G8D99_RS05190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G8D99_RS05200	COG0527	aspartate kinase activity
G8D99_RS05205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8D99_RS05210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G8D99_RS05225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G8D99_RS05230	COG1522	sequence-specific DNA binding
G8D99_RS05240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G8D99_RS05260	COG0667	Aldo Keto reductase
G8D99_RS05270	COG1765	OsmC-like protein
G8D99_RS05280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8D99_RS05285	COG1045	serine acetyltransferase
G8D99_RS05310	COG0540	Belongs to the ATCase OTCase family
G8D99_RS05320	COG2885	chlorophyll binding
G8D99_RS05335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G8D99_RS05340	COG0659	secondary active sulfate transmembrane transporter activity
G8D99_RS05345	COG0625	glutathione transferase activity
G8D99_RS05360	COG2363	Small membrane protein
G8D99_RS05375	COG1278	Cold shock
G8D99_RS05380	COG0513	Belongs to the DEAD box helicase family
G8D99_RS05390	COG0778	Nitroreductase
G8D99_RS05415	COG0167	dihydroorotate dehydrogenase activity
G8D99_RS05445	COG4783	chaperone-mediated protein folding
G8D99_RS05460	COG1610	YqeY-like protein
G8D99_RS05560	COG2011	ABC-type metal ion transport system permease component
G8D99_RS05565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8D99_RS05605	COG0138	bifunctional purine biosynthesis protein purh
G8D99_RS05610	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G8D99_RS05645	COG2308	Evidence 4 Homologs of previously reported genes of
G8D99_RS05655	COG1305	Transglutaminase-like
G8D99_RS05665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G8D99_RS05670	COG0305	Participates in initiation and elongation during chromosome replication
G8D99_RS05680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G8D99_RS05685	COG0360	Binds together with S18 to 16S ribosomal RNA
G8D99_RS05695	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G8D99_RS05700	COG1845	cytochrome c oxidase, subunit III
G8D99_RS05705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G8D99_RS05740	COG1215	transferase activity, transferring glycosyl groups
G8D99_RS05760	COG4682	membrane
G8D99_RS05765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8D99_RS05785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G8D99_RS05790	COG2890	protein-(glutamine-N5) methyltransferase activity
G8D99_RS05820	COG0583	DNA-binding transcription factor activity
G8D99_RS05830	COG0477	Major facilitator Superfamily
G8D99_RS05835	COG0729	surface antigen
G8D99_RS05890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8D99_RS05895	COG0786	glutamate:sodium symporter activity
G8D99_RS05905	COG0583	DNA-binding transcription factor activity
G8D99_RS05910	COG0668	transmembrane transport
G8D99_RS05915	COG2707	UPF0756 membrane protein
G8D99_RS05920	COG1187	pseudouridine synthase activity
G8D99_RS05940	COG0802	atpase or kinase
G8D99_RS05945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G8D99_RS05950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G8D99_RS05955	COG1923	regulation of RNA biosynthetic process
G8D99_RS05960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8D99_RS05970	COG3178	'Phosphotransferase
G8D99_RS05975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G8D99_RS05985	COG1192	Involved in chromosome partitioning
G8D99_RS05990	COG1475	DNA binding
G8D99_RS05995	COG0811	peptide transport
G8D99_RS06005	COG1132	(ABC) transporter
G8D99_RS06010	COG1663	tetraacyldisaccharide 4'-kinase activity
G8D99_RS06030	COG0084	hydrolase, TatD family'
G8D99_RS06040	COG2165	general secretion pathway protein
G8D99_RS06050	COG4795	General secretion pathway protein
G8D99_RS06065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G8D99_RS06095	COG0776	regulation of translation
G8D99_RS06135	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G8D99_RS06145	COG0012	GTP binding
G8D99_RS06150	COG2011	ABC-type metal ion transport system permease component
G8D99_RS06155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8D99_RS06160	COG1464	Belongs to the NlpA lipoprotein family
G8D99_RS06260	COG1203	CRISPR-associated helicase, Cas3
G8D99_RS06280	COG0582	viral genome integration into host DNA
G8D99_RS06425	COG1104	cysteine desulfurase activity
G8D99_RS06440	COG0697	spore germination
G8D99_RS06440	COG1674	ftsk spoiiie
G8D99_RS06455	COG2011	ABC-type metal ion transport system permease component
G8D99_RS06490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8D99_RS06495	COG2011	ABC-type metal ion transport system permease component
G8D99_RS06510	COG0477	Major facilitator Superfamily
G8D99_RS06540	COG0583	DNA-binding transcription factor activity
G8D99_RS06555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8D99_RS06560	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS06565	COG1024	Enoyl-CoA hydratase
G8D99_RS06575	COG0477	Major facilitator Superfamily
G8D99_RS06595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G8D99_RS06595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G8D99_RS06600	COG1254	Belongs to the acylphosphatase family
G8D99_RS06630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G8D99_RS06640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G8D99_RS06655	COG2353	YceI-like domain
G8D99_RS06660	COG1280	lysine exporter protein (LysE YggA)
G8D99_RS06665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8D99_RS06665	COG0519	Catalyzes the synthesis of GMP from XMP
G8D99_RS06670	COG4221	oxidoreductase activity
G8D99_RS06680	COG1064	alcohol dehydrogenase
G8D99_RS06695	COG0531	amino acid
G8D99_RS06725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8D99_RS06750	COG0308	aminopeptidase N
G8D99_RS06775	COG1027	Aspartate ammonia-lyase
G8D99_RS06785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G8D99_RS06790	COG2267	carboxylic ester hydrolase activity
G8D99_RS06800	COG1902	pentaerythritol trinitrate reductase activity
G8D99_RS06800	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8D99_RS06835	COG0148	phosphopyruvate hydratase activity
G8D99_RS06840	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G8D99_RS06925	COG0583	DNA-binding transcription factor activity
G8D99_RS06930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8D99_RS06940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8D99_RS06945	COG0569	domain protein
G8D99_RS06955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G8D99_RS06960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G8D99_RS06995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G8D99_RS07000	COG0542	response to heat
G8D99_RS07030	COG0372	Belongs to the citrate synthase family
G8D99_RS07040	COG2204	response regulator
G8D99_RS07045	COG3852	Histidine kinase
G8D99_RS07055	COG0528	UMP kinase activity
G8D99_RS07065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G8D99_RS07070	COG0575	Belongs to the CDS family
G8D99_RS07085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8D99_RS07105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8D99_RS07120	COG2137	regulation of response to DNA damage stimulus
G8D99_RS07125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G8D99_RS07130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G8D99_RS07135	COG1011	Hydrolase
G8D99_RS07150	COG0477	Major facilitator Superfamily
G8D99_RS07160	COG0702	epimerase
G8D99_RS07165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8D99_RS07180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8D99_RS07210	COG0316	Belongs to the HesB IscA family
G8D99_RS07215	COG0822	iron-sulfur transferase activity
G8D99_RS07240	COG0776	regulation of translation
G8D99_RS07250	COG2207	Transcriptional regulator
G8D99_RS07270	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS07275	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS07290	COG1278	Cold shock
G8D99_RS07325	COG0589	response to stress
G8D99_RS07355	COG3706	GGDEF domain
G8D99_RS07365	COG0439	Biotin carboxylase
G8D99_RS07370	COG0511	ligase activity, forming carbon-carbon bonds
G8D99_RS07380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8D99_RS07400	COG3501	Rhs element vgr protein
G8D99_RS07470	COG3209	COG3209 Rhs family protein
G8D99_RS07495	COG3209	COG3209 Rhs family protein
G8D99_RS07535	COG3209	COG3209 Rhs family protein
G8D99_RS07585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G8D99_RS07590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8D99_RS07605	COG1598	PFAM Uncharacterised protein family UPF0150
G8D99_RS07620	COG2814	Major facilitator Superfamily
G8D99_RS07635	COG1525	nuclease
G8D99_RS07640	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS07680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8D99_RS07690	COG1448	Aminotransferase
G8D99_RS07695	COG0596	Alpha beta hydrolase
G8D99_RS07700	COG5001	Diguanylate cyclase
G8D99_RS07700	COG3300	MHYT domain
G8D99_RS07705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8D99_RS07730	COG1132	(ABC) transporter
G8D99_RS07775	COG3501	Rhs element vgr protein
G8D99_RS07795	COG3209	COG3209 Rhs family protein
G8D99_RS07805	COG3209	COG3209 Rhs family protein
G8D99_RS07820	COG4372	Transposase
G8D99_RS07845	COG3209	COG3209 Rhs family protein
G8D99_RS07885	COG3209	COG3209 Rhs family protein
G8D99_RS07925	COG0129	dihydroxy-acid dehydratase activity
G8D99_RS07935	COG0583	DNA-binding transcription factor activity
G8D99_RS07945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8D99_RS07955	COG2084	Dehydrogenase
G8D99_RS07960	COG2814	Major facilitator Superfamily
G8D99_RS07970	COG0640	Transcriptional regulator
G8D99_RS07980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8D99_RS07985	COG1309	transcriptional regulator
G8D99_RS08010	COG0583	DNA-binding transcription factor activity
G8D99_RS08025	COG0640	Transcriptional regulator
G8D99_RS08045	COG0604	alcohol dehydrogenase
G8D99_RS08045	COG3321	synthase
G8D99_RS08045	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS08050	COG5002	protein histidine kinase activity
G8D99_RS08065	COG2351	hydroxyisourate hydrolase activity
G8D99_RS08080	COG5001	Diguanylate cyclase
G8D99_RS08085	COG4628	conserved protein (DUF2132)
G8D99_RS08090	COG2801	Transposase and inactivated derivatives
G8D99_RS08125	COG1012	belongs to the aldehyde dehydrogenase family
G8D99_RS08145	COG2186	Transcriptional regulator
G8D99_RS08150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8D99_RS08160	COG1294	oxidase, subunit
G8D99_RS08165	COG1271	oxidase subunit
G8D99_RS08170	COG0318	PFAM AMP-dependent synthetase and ligase
G8D99_RS08175	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS08185	COG0183	Belongs to the thiolase family
G8D99_RS08190	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8D99_RS08200	COG2814	Major facilitator Superfamily
G8D99_RS08215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D99_RS08240	COG0864	Transcriptional regulator
G8D99_RS08255	COG0439	Biotin carboxylase
G8D99_RS08270	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G8D99_RS08275	COG4149	molybdate abc transporter
G8D99_RS08280	COG0725	ABC transporter, periplasmic molybdate-binding protein
G8D99_RS08285	COG0303	'Molybdopterin
G8D99_RS08290	COG0315	cyclic pyranopterin monophosphate synthase activity
G8D99_RS08290	COG0521	Mo-molybdopterin cofactor biosynthetic process
G8D99_RS08295	COG0314	molybdopterin synthase activity
G8D99_RS08305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G8D99_RS08315	COG0243	molybdopterin cofactor binding
G8D99_RS08320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8D99_RS08325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8D99_RS08330	COG2223	nitrite transmembrane transporter activity
G8D99_RS08335	COG0745	RESPONSE REGULATOR receiver
G8D99_RS08340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D99_RS08340	COG1116	anion transmembrane transporter activity
G8D99_RS08345	COG2706	6-phosphogluconolactonase activity
G8D99_RS08355	COG0318	PFAM AMP-dependent synthetase and ligase
G8D99_RS08365	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G8D99_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS08375	COG1846	Transcriptional regulator
G8D99_RS08380	COG2814	Major facilitator Superfamily
G8D99_RS08385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8D99_RS08390	COG2814	Major facilitator Superfamily
G8D99_RS08395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8D99_RS08405	COG2814	Major facilitator Superfamily
G8D99_RS08410	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS08415	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS08430	COG2814	Major facilitator Superfamily
G8D99_RS08435	COG1846	Transcriptional regulator
G8D99_RS08440	COG0583	DNA-binding transcription factor activity
G8D99_RS08445	COG4948	Mandelate Racemase Muconate Lactonizing
G8D99_RS08450	COG4829	muconolactone delta-isomerase
G8D99_RS08460	COG4638	Rieske (2fe-2S)
G8D99_RS08465	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G8D99_RS08470	COG0543	2 iron, 2 sulfur cluster binding
G8D99_RS08470	COG0633	Ferredoxin
G8D99_RS08475	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS08480	COG3135	benzoate transporter
G8D99_RS08485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8D99_RS08490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8D99_RS08495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8D99_RS08505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8D99_RS08510	COG0183	Belongs to the thiolase family
G8D99_RS08515	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8D99_RS08520	COG1024	Enoyl-CoA hydratase
G8D99_RS08525	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS08530	COG2814	Major facilitator Superfamily
G8D99_RS08535	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G8D99_RS08535	COG0644	oxidoreductase
G8D99_RS08550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D99_RS08560	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G8D99_RS08565	COG2223	nitrite transmembrane transporter activity
G8D99_RS08595	COG3040	lipid binding
G8D99_RS08605	COG2194	sulfuric ester hydrolase activity
G8D99_RS08610	COG0745	RESPONSE REGULATOR receiver
G8D99_RS08645	COG2072	flavoprotein involved in K transport
G8D99_RS08650	COG0318	PFAM AMP-dependent synthetase and ligase
G8D99_RS08655	COG0427	acetyl-CoA hydrolase
G8D99_RS08660	COG0183	Belongs to the thiolase family
G8D99_RS08665	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS08675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8D99_RS08690	COG0318	PFAM AMP-dependent synthetase and ligase
G8D99_RS08695	COG1309	transcriptional regulator
G8D99_RS08700	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS08705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8D99_RS08710	COG1024	Enoyl-CoA hydratase
G8D99_RS08715	COG4770	biotin carboxylase activity
G8D99_RS08730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8D99_RS08735	COG2031	fatty acid transporter
G8D99_RS08755	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
G8D99_RS08765	COG2153	protein acetylation
G8D99_RS08770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8D99_RS08780	COG1585	Membrane protein implicated in regulation of membrane protease activity
G8D99_RS08805	COG1294	oxidase, subunit
G8D99_RS08810	COG4890	Cyd operon protein YbgT
G8D99_RS08840	COG0552	protein localization to endoplasmic reticulum
G8D99_RS08845	COG0612	Peptidase, M16
G8D99_RS08875	COG0517	IMP dehydrogenase activity
G8D99_RS08880	COG0133	tryptophan synthase activity
G8D99_RS08890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8D99_RS08910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G8D99_RS08940	COG0537	adenosine 5'-monophosphoramidase activity
G8D99_RS08960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G8D99_RS08985	COG2223	nitrite transmembrane transporter activity
G8D99_RS09020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8D99_RS09025	COG2267	carboxylic ester hydrolase activity
G8D99_RS09030	COG0671	phosphoesterase, PA-phosphatase related
G8D99_RS09030	COG2453	phosphatase
G8D99_RS09045	COG4589	Belongs to the CDS family
G8D99_RS09055	COG2814	Major facilitator Superfamily
G8D99_RS09105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8D99_RS09115	COG0730	response to heat
G8D99_RS09120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8D99_RS09140	COG0697	spore germination
G8D99_RS09155	COG0126	phosphoglycerate kinase activity
G8D99_RS09165	COG0424	maF-like protein
G8D99_RS09235	COG2850	peptidyl-arginine hydroxylation
G8D99_RS09240	COG0069	glutamate synthase activity
G8D99_RS09260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8D99_RS09265	COG1454	alcohol dehydrogenase
G8D99_RS09270	COG0824	Thioesterase
G8D99_RS09275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G8D99_RS09295	COG0183	Belongs to the thiolase family
G8D99_RS09315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8D99_RS09325	COG3135	benzoate transporter
G8D99_RS09330	COG0024	Methionine aminopeptidase
G8D99_RS09355	COG1253	flavin adenine dinucleotide binding
G8D99_RS09380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G8D99_RS09385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G8D99_RS09395	COG2431	L-lysine efflux transmembrane transporter activity
G8D99_RS09405	COG0386	Belongs to the glutathione peroxidase family
G8D99_RS09410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8D99_RS09415	COG0436	Aminotransferase
G8D99_RS09475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G8D99_RS09485	COG4122	O-methyltransferase activity
G8D99_RS09525	COG1132	(ABC) transporter
G8D99_RS09535	COG1137	ATPase activity
G8D99_RS09540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G8D99_RS09550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G8D99_RS09555	COG0517	IMP dehydrogenase activity
G8D99_RS09555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G8D99_RS09695	COG1643	Atp-dependent helicase
G8D99_RS09725	COG3634	alkyl hydroperoxide reductase activity
G8D99_RS09735	COG1301	dicarboxylic acid transport
G8D99_RS09770	COG2304	oxidoreductase activity
G8D99_RS09810	COG1358	cellular component organization or biogenesis
G8D99_RS09845	COG4245	von Willebrand factor, type A
G8D99_RS09865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G8D99_RS09895	COG1733	regulation of RNA biosynthetic process
G8D99_RS09900	COG0702	epimerase
G8D99_RS09935	COG3040	lipid binding
G8D99_RS09940	COG0556	nucleotide-excision repair
G8D99_RS09955	COG3706	GGDEF domain
G8D99_RS09965	COG0436	Aminotransferase
G8D99_RS10000	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G8D99_RS10005	COG1381	Involved in DNA repair and RecF pathway recombination
G8D99_RS10015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G8D99_RS10045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8D99_RS10065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8D99_RS10075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8D99_RS10090	COG4208	sulfate ABC transporter
G8D99_RS10095	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8D99_RS10100	COG0583	DNA-binding transcription factor activity
G8D99_RS10115	COG0602	queuosine metabolic process
G8D99_RS10125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G8D99_RS10135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G8D99_RS10145	COG0583	DNA-binding transcription factor activity
G8D99_RS10150	COG1056	cytidyltransferase-related domain
G8D99_RS10150	COG1051	belongs to the nudix hydrolase family
G8D99_RS10155	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G8D99_RS10160	COG0778	Nitroreductase
G8D99_RS10165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8D99_RS10165	COG3323	Protein of unknown function (DUF1653)
G8D99_RS10175	COG0047	phosphoribosylformylglycinamidine synthase activity
G8D99_RS10175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8D99_RS10190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8D99_RS10210	COG0076	glutamate decarboxylase activity
G8D99_RS10215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G8D99_RS10240	COG1309	transcriptional regulator
G8D99_RS10245	COG1022	Amp-dependent synthetase and ligase
G8D99_RS10250	COG1454	alcohol dehydrogenase
G8D99_RS10260	COG2175	clavaminate synthase activity
G8D99_RS10275	COG0385	Bile acid
G8D99_RS10305	COG0352	thiamine-phosphate diphosphorylase activity
G8D99_RS10315	COG3025	triphosphatase activity
G8D99_RS10325	COG1309	transcriptional regulator
G8D99_RS10350	COG0612	Peptidase, M16
G8D99_RS10385	COG0402	S-adenosylhomocysteine deaminase activity
G8D99_RS10395	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G8D99_RS10405	COG1686	Belongs to the peptidase S11 family
G8D99_RS10410	COG1252	NADH dehydrogenase
G8D99_RS10450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G8D99_RS10465	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS10470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8D99_RS10475	COG3139	Protein of unknown function (DUF1315)
G8D99_RS10480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8D99_RS10485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8D99_RS10495	COG0494	nUDIX hydrolase
G8D99_RS10510	COG0745	RESPONSE REGULATOR receiver
G8D99_RS10520	COG3111	PFAM Bacterial OB fold (BOF) protein
G8D99_RS10525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8D99_RS10540	COG1720	tRNA m6t6A37 methyltransferase activity
G8D99_RS10550	COG0431	NADPH-dependent FMN reductase
G8D99_RS10555	COG0798	PFAM Bile acid sodium symporter
G8D99_RS10560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8D99_RS10565	COG0640	Transcriptional regulator
G8D99_RS10575	COG3634	alkyl hydroperoxide reductase activity
G8D99_RS10615	COG0628	permease
G8D99_RS10620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G8D99_RS10625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8D99_RS10645	COG0658	competence protein
G8D99_RS10645	COG2333	competence protein COMEC
G8D99_RS10650	COG1136	(ABC) transporter
G8D99_RS10655	COG4591	ABC-type transport system involved in lipoprotein release permease component
G8D99_RS10670	COG1671	Belongs to the UPF0178 family
G8D99_RS10675	COG0833	amino acid
G8D99_RS10690	COG0833	amino acid
G8D99_RS10710	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
G8D99_RS10720	COG4172	Belongs to the ABC transporter superfamily
G8D99_RS10725	COG4239	(ABC) transporter, permease
G8D99_RS10730	COG4174	ABC transporter (Permease)
G8D99_RS10735	COG4166	transmembrane transport
G8D99_RS10740	COG0741	lytic transglycosylase activity
G8D99_RS10740	COG1388	LysM domain
G8D99_RS10790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8D99_RS10795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8D99_RS10800	COG3706	GGDEF domain
G8D99_RS10805	COG0006	proline dipeptidase activity
G8D99_RS10810	COG3079	Belongs to the UPF0149 family
G8D99_RS10860	COG1053	succinate dehydrogenase
G8D99_RS10865	COG0583	DNA-binding transcription factor activity
G8D99_RS10870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8D99_RS10875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G8D99_RS10915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G8D99_RS10925	COG2234	aminopeptidase activity
G8D99_RS10930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G8D99_RS10935	COG3384	dioxygenase
G8D99_RS10945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8D99_RS10950	COG2878	Part of a membrane complex involved in electron transport
G8D99_RS10955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G8D99_RS10980	COG0768	penicillin binding
G8D99_RS10985	COG0742	ribosomal rna small subunit methyltransferase
G8D99_RS11015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G8D99_RS11025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8D99_RS11040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G8D99_RS11045	COG1053	succinate dehydrogenase
G8D99_RS11050	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G8D99_RS11055	COG2009	succinate dehydrogenase
G8D99_RS11065	COG2072	flavoprotein involved in K transport
G8D99_RS11070	COG0300	oxidoreductase activity
G8D99_RS11085	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G8D99_RS11090	COG0714	Associated with various cellular activities
G8D99_RS11100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G8D99_RS11100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8D99_RS11130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G8D99_RS11140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G8D99_RS11165	COG0564	pseudouridine synthase activity
G8D99_RS11190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G8D99_RS11220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8D99_RS11225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G8D99_RS11280	COG0321	lipoyl(octanoyl) transferase activity
G8D99_RS11295	COG0531	amino acid
G8D99_RS11305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G8D99_RS11310	COG1648	precorrin-2 dehydrogenase activity
G8D99_RS11310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G8D99_RS11335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G8D99_RS11350	COG0671	phosphoesterase, PA-phosphatase related
G8D99_RS11355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D99_RS11365	COG1538	Outer membrane efflux protein
G8D99_RS11370	COG0393	Putative heavy-metal-binding
G8D99_RS11375	COG0393	Putative heavy-metal-binding
G8D99_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS11390	COG0525	valine-tRNA ligase activity
G8D99_RS11400	COG2852	Protein conserved in bacteria
G8D99_RS11420	COG3706	GGDEF domain
G8D99_RS11425	COG4221	oxidoreductase activity
G8D99_RS11425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8D99_RS11425	COG0604	alcohol dehydrogenase
G8D99_RS11425	COG3321	synthase
G8D99_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS11450	COG2175	clavaminate synthase activity
G8D99_RS11455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D99_RS11460	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G8D99_RS11465	COG4521	taurine ABC transporter
G8D99_RS11475	COG0175	sulfate reduction
G8D99_RS11500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8D99_RS11505	COG1773	rubredoxin
G8D99_RS11510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8D99_RS11520	COG0583	DNA-binding transcription factor activity
G8D99_RS11540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G8D99_RS11545	COG4181	ATPase activity
G8D99_RS11555	COG0288	reversible hydration of carbon dioxide
G8D99_RS11570	COG0500	methyltransferase
G8D99_RS11575	COG4771	TonB-dependent receptor
G8D99_RS11590	COG4607	ABC-type enterochelin transport system periplasmic component
G8D99_RS11600	COG0306	phosphate transporter
G8D99_RS11615	COG2852	Protein conserved in bacteria
G8D99_RS11620	COG2376	Dihydroxyacetone kinase
G8D99_RS11635	COG0242	peptide deformylase activity
G8D99_RS11645	COG3706	GGDEF domain
G8D99_RS11670	COG1024	Enoyl-CoA hydratase
G8D99_RS11725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G8D99_RS11730	COG2814	Major facilitator Superfamily
G8D99_RS11735	COG1566	PFAM secretion protein HlyD family protein
G8D99_RS11740	COG2050	protein possibly involved in aromatic compounds catabolism
G8D99_RS11750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D99_RS11765	COG0420	3'-5' exonuclease activity
G8D99_RS11795	COG0735	belongs to the Fur family
G8D99_RS11800	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8D99_RS11805	COG2914	Belongs to the UPF0125 (RnfH) family
G8D99_RS11820	COG0121	glutamine amidotransferase
G8D99_RS11830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8D99_RS11835	COG0756	dUTP diphosphatase activity
G8D99_RS11840	COG0210	DNA helicase
G8D99_RS11845	COG2885	chlorophyll binding
G8D99_RS11850	COG2885	chlorophyll binding
G8D99_RS11855	COG0204	Acyl-transferase
G8D99_RS11865	COG0850	regulation of cytokinetic process
G8D99_RS11870	COG2894	cell division
G8D99_RS11875	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G8D99_RS11890	COG1674	ftsk spoiiie
G8D99_RS11890	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G8D99_RS11895	COG0492	ferredoxin-NADP+ reductase activity
G8D99_RS11900	COG0500	methyltransferase
G8D99_RS11905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G8D99_RS11915	COG0456	acetyltransferase
G8D99_RS11940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G8D99_RS11975	COG0351	phosphomethylpyrimidine kinase
G8D99_RS11975	COG0352	thiamine-phosphate diphosphorylase activity
G8D99_RS11985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8D99_RS12005	COG2132	Multicopper oxidase
G8D99_RS12015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G8D99_RS12030	COG4269	membrane
G8D99_RS12050	COG1968	undecaprenyl-diphosphatase activity
G8D99_RS12055	COG1214	PFAM Peptidase M22, glycoprotease
G8D99_RS12065	COG0494	nUDIX hydrolase
G8D99_RS12115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G8D99_RS12120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G8D99_RS12145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8D99_RS12150	COG0765	amino acid transport
G8D99_RS12155	COG0765	amino acid transport
G8D99_RS12160	COG1126	abc transporter atp-binding protein
G8D99_RS12200	COG2199	diguanylate cyclase activity
G8D99_RS12230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G8D99_RS12235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G8D99_RS12250	COG0450	alkyl hydroperoxide reductase
G8D99_RS12270	COG0285	dihydrofolate synthase activity
G8D99_RS12315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8D99_RS12320	COG2207	Transcriptional regulator
G8D99_RS12330	COG0183	Belongs to the thiolase family
G8D99_RS12335	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8D99_RS12335	COG1024	Enoyl-CoA hydratase
G8D99_RS12345	COG2153	protein acetylation
G8D99_RS12355	COG1272	protein, Hemolysin III
G8D99_RS12360	COG0477	Major facilitator Superfamily
G8D99_RS12365	COG1408	metallophosphoesterase
G8D99_RS12370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8D99_RS12385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8D99_RS12395	COG1346	cytolysis
G8D99_RS12410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G8D99_RS12415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G8D99_RS12420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G8D99_RS12425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8D99_RS12430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G8D99_RS12440	COG2969	positive regulation of protein catabolic process
G8D99_RS12460	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS12465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8D99_RS12480	COG1309	transcriptional regulator
G8D99_RS12490	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS12520	COG2853	Lipoprotein
G8D99_RS12535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8D99_RS12540	COG1764	response to oxidative stress
G8D99_RS12545	COG2801	Transposase and inactivated derivatives
G8D99_RS12575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8D99_RS12575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8D99_RS12590	COG0037	tRNA processing
G8D99_RS12620	COG0776	regulation of translation
G8D99_RS12625	COG0072	phenylalanine-tRNA ligase activity
G8D99_RS12630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G8D99_RS12675	COG0625	glutathione transferase activity
G8D99_RS12685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G8D99_RS12695	COG0318	PFAM AMP-dependent synthetase and ligase
G8D99_RS12705	COG3028	Belongs to the UPF0307 family
G8D99_RS12715	COG1660	Displays ATPase and GTPase activities
G8D99_RS12720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G8D99_RS12730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8D99_RS12735	COG0617	tRNA 3'-terminal CCA addition
G8D99_RS12740	COG1555	photosystem II stabilization
G8D99_RS12745	COG3956	TIGRFAM MazG family protein
G8D99_RS12750	COG4221	oxidoreductase activity
G8D99_RS12755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8D99_RS12770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8D99_RS12775	COG5002	protein histidine kinase activity
G8D99_RS12775	COG0784	Response regulator, receiver
G8D99_RS12775	COG2205	protein histidine kinase activity
G8D99_RS12780	COG1024	Enoyl-CoA hydratase
G8D99_RS12785	COG2084	Dehydrogenase
G8D99_RS12790	COG3622	Belongs to the hyi family
G8D99_RS12835	COG2814	Major facilitator Superfamily
G8D99_RS12845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8D99_RS12850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G8D99_RS12855	COG0084	hydrolase, TatD family'
G8D99_RS12870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G8D99_RS12880	COG0793	Belongs to the peptidase S41A family
G8D99_RS12905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G8D99_RS12910	COG0857	belongs to the CobB CobQ family
G8D99_RS12910	COG0280	phosphate acetyltransferase
G8D99_RS12915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G8D99_RS12915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G8D99_RS12940	COG0740	serine-type endopeptidase activity
G8D99_RS12950	COG4774	siderophore transport
G8D99_RS12960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G8D99_RS12965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8D99_RS12970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8D99_RS12970	COG2813	Specifically methylates the guanine in position
G8D99_RS13080	COG0788	formyltetrahydrofolate deformylase activity
G8D99_RS13105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G8D99_RS13105	COG4651	solute:proton antiporter activity
G8D99_RS13125	COG0210	DNA helicase
G8D99_RS13130	COG1929	Belongs to the glycerate kinase type-1 family
G8D99_RS13155	COG2900	Belongs to the SlyX family
G8D99_RS13175	COG0830	nickel cation binding
G8D99_RS13200	COG0804	urea catabolic process
G8D99_RS13220	COG1560	Kdo2-lipid A biosynthetic process
G8D99_RS13245	COG0252	asparaginase activity
G8D99_RS13270	COG0473	3-isopropylmalate dehydrogenase activity
G8D99_RS13285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G8D99_RS13295	COG0583	DNA-binding transcription factor activity
G8D99_RS13305	COG2610	gluconate transmembrane transporter activity
G8D99_RS13335	COG1960	acyl-CoA dehydrogenase activity
G8D99_RS13345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G8D99_RS13355	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8D99_RS13360	COG3384	dioxygenase
G8D99_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS13380	COG4638	Rieske (2fe-2S)
G8D99_RS13385	COG0583	DNA-binding transcription factor activity
G8D99_RS13405	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G8D99_RS13410	COG3971	2-oxopent-4-enoate hydratase activity
G8D99_RS13420	COG0564	pseudouridine synthase activity
G8D99_RS13425	COG1530	ribonuclease E activity
G8D99_RS13430	COG0318	PFAM AMP-dependent synthetase and ligase
G8D99_RS13460	COG1983	PspC domain protein
G8D99_RS13485	COG0751	glycine-tRNA ligase activity
G8D99_RS13515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8D99_RS13565	COG0628	permease
G8D99_RS13570	COG2032	superoxide dismutase activity
G8D99_RS13575	COG1289	transmembrane transporter activity
G8D99_RS13605	COG0277	FAD linked oxidase domain protein
G8D99_RS13610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8D99_RS13615	COG5006	permease, DMT superfamily
G8D99_RS13620	COG5006	permease, DMT superfamily
G8D99_RS13635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G8D99_RS13640	COG5380	lipid catabolic process
G8D99_RS13645	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G8D99_RS13650	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G8D99_RS13660	COG0335	large ribosomal subunit rRNA binding
G8D99_RS13670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G8D99_RS13675	COG0228	four-way junction DNA binding
G8D99_RS13810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G8D99_RS13815	COG0194	GDP metabolic process
G8D99_RS13820	COG1758	RNA polymerase activity
G8D99_RS13825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8D99_RS13845	COG3307	-O-antigen
G8D99_RS13855	COG4969	Belongs to the N-Me-Phe pilin family
G8D99_RS13865	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G8D99_RS13870	COG1704	LemA family
G8D99_RS13880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G8D99_RS13890	COG0195	Participates in both transcription termination and antitermination
G8D99_RS13895	COG0779	Required for maturation of 30S ribosomal subunits
G8D99_RS13945	COG0237	dephospho-CoA kinase activity
G8D99_RS13955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8D99_RS13970	COG0497	DNA recombination
G8D99_RS13980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G8D99_RS14010	COG1132	(ABC) transporter
G8D99_RS14015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8D99_RS14055	COG1024	Enoyl-CoA hydratase
G8D99_RS14055	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8D99_RS14060	COG0183	Belongs to the thiolase family
G8D99_RS14085	COG2199	diguanylate cyclase activity
G8D99_RS14085	COG2203	Gaf domain
G8D99_RS14095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G8D99_RS14115	COG0326	Molecular chaperone. Has ATPase activity
G8D99_RS14130	COG2056	Na+-H+ antiporter family
G8D99_RS14160	COG0085	RNA polymerase activity
G8D99_RS14165	COG0222	ribosome binding
G8D99_RS14170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G8D99_RS14175	COG0081	regulation of translation
G8D99_RS14180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G8D99_RS14190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G8D99_RS14230	COG0546	phosphoglycolate phosphatase activity
G8D99_RS14280	COG0181	hydroxymethylbilane synthase activity
G8D99_RS14290	COG3275	phosphorelay sensor kinase activity
G8D99_RS14340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G8D99_RS14345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8D99_RS14355	COG0772	Belongs to the SEDS family
G8D99_RS14380	COG4974	Belongs to the 'phage' integrase family
G8D99_RS14385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8D99_RS14395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G8D99_RS14400	COG1686	Belongs to the peptidase S11 family
G8D99_RS14405	COG2197	response regulator
G8D99_RS14410	COG5002	protein histidine kinase activity
G8D99_RS14420	COG0793	Belongs to the peptidase S41A family
G8D99_RS14425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G8D99_RS14430	COG0795	lipopolysaccharide-transporting ATPase activity
G8D99_RS14435	COG0795	lipopolysaccharide-transporting ATPase activity
G8D99_RS14455	COG0586	Pfam SNARE associated Golgi protein
G8D99_RS14470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8D99_RS14470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8D99_RS14475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8D99_RS14480	COG0004	ammonium transporteR
G8D99_RS14485	COG0347	Belongs to the P(II) protein family
G8D99_RS14495	COG0606	chelatase, subunit chli
G8D99_RS14515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G8D99_RS14530	COG0318	PFAM AMP-dependent synthetase and ligase
G8D99_RS14540	COG0477	Major facilitator Superfamily
G8D99_RS14545	COG2860	membrane
G8D99_RS14555	COG1253	flavin adenine dinucleotide binding
G8D99_RS14580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8D99_RS14605	COG2814	Major facilitator Superfamily
G8D99_RS14610	COG0693	protein deglycase activity
G8D99_RS14625	COG2814	Major facilitator Superfamily
G8D99_RS14670	COG1652	LysM domain
G8D99_RS14675	COG0758	DNA mediated transformation
G8D99_RS14695	COG0386	Belongs to the glutathione peroxidase family
G8D99_RS14730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G8D99_RS14740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G8D99_RS14780	COG1121	(ABC) transporter
G8D99_RS14785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8D99_RS14800	COG2837	iron assimilation
G8D99_RS14820	COG3501	Rhs element vgr protein
G8D99_RS14825	COG0281	malic enzyme
G8D99_RS14870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8D99_RS14870	COG0519	Catalyzes the synthesis of GMP from XMP
G8D99_RS14875	COG2259	Doxx family
G8D99_RS14880	COG0586	Pfam SNARE associated Golgi protein
G8D99_RS14900	COG0271	Belongs to the BolA IbaG family
G8D99_RS14975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8D99_RS14980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8D99_RS14995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G8D99_RS15000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G8D99_RS15010	COG0297	glycogen (starch) synthase activity
G8D99_RS15020	COG0438	transferase activity, transferring glycosyl groups
G8D99_RS15045	COG1091	dTDP-4-dehydrorhamnose reductase activity
G8D99_RS15050	COG1088	dTDP-glucose 4,6-dehydratase activity
G8D99_RS15060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G8D99_RS15070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G8D99_RS15075	COG0438	transferase activity, transferring glycosyl groups
G8D99_RS15080	COG0438	transferase activity, transferring glycosyl groups
G8D99_RS15085	COG0438	transferase activity, transferring glycosyl groups
G8D99_RS15110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G8D99_RS15115	COG1596	polysaccharide export
G8D99_RS15190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G8D99_RS15195	COG0546	phosphoglycolate phosphatase activity
G8D99_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
G8D99_RS15235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D99_RS15245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G8D99_RS15255	COG2233	PERMEase
G8D99_RS15300	COG3539	Fimbrial protein
G8D99_RS15335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8D99_RS15345	COG0733	neurotransmitter:sodium symporter activity
G8D99_RS15350	COG3738	Protein conserved in bacteria
G8D99_RS15355	COG1012	belongs to the aldehyde dehydrogenase family
G8D99_RS15395	COG2951	lytic endotransglycosylase activity
G8D99_RS15400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G8D99_RS15415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8D99_RS15435	COG2388	GCN5-related N-acetyl-transferase
G8D99_RS15440	COG2814	Major facilitator Superfamily
G8D99_RS15445	COG0861	Integral membrane protein TerC family
G8D99_RS15455	COG0402	S-adenosylhomocysteine deaminase activity
G8D99_RS15485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G8D99_RS15490	COG0594	ribonuclease P activity