locus-tag	class	description
H7R46_RS00010	COG0592	DNA-directed DNA polymerase activity
H7R46_RS00020	COG0187	DNA topoisomerase II activity
H7R46_RS00035	COG0488	(ABC) transporter
H7R46_RS00060	COG0596	Alpha beta hydrolase
H7R46_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7R46_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R46_RS00105	COG0625	glutathione transferase activity
H7R46_RS00115	COG0733	neurotransmitter:sodium symporter activity
H7R46_RS00155	COG2233	PERMEase
H7R46_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R46_RS00205	COG2814	Major facilitator Superfamily
H7R46_RS00210	COG0656	L-ascorbic acid biosynthetic process
H7R46_RS00215	COG0583	DNA-binding transcription factor activity
H7R46_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R46_RS00235	COG1064	alcohol dehydrogenase
H7R46_RS00240	COG2818	Glycosylase
H7R46_RS00255	COG1194	a g-specific adenine glycosylase
H7R46_RS00270	COG5487	UPF0391 membrane protein
H7R46_RS00275	COG2983	Belongs to the UPF0260 family
H7R46_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7R46_RS00290	COG2116	formate transmembrane transporter activity
H7R46_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R46_RS00315	COG1335	isochorismatase
H7R46_RS00320	COG0385	Bile acid
H7R46_RS00325	COG0534	Mate efflux family protein
H7R46_RS00330	COG1683	Conserved Protein
H7R46_RS00345	COG0346	lactoylglutathione lyase activity
H7R46_RS00350	COG0625	glutathione transferase activity
H7R46_RS00360	COG1113	amino acid transport
H7R46_RS00370	COG0523	cobalamin synthesis protein
H7R46_RS00380	COG2188	Transcriptional regulator
H7R46_RS00410	COG0010	Belongs to the arginase family
H7R46_RS00475	COG0546	phosphoglycolate phosphatase activity
H7R46_RS00480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7R46_RS00490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7R46_RS00500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7R46_RS00505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7R46_RS00605	COG0534	Mate efflux family protein
H7R46_RS00610	COG0436	Aminotransferase
H7R46_RS00615	COG2733	membrane
H7R46_RS00630	COG2918	glutathione biosynthetic process
H7R46_RS00645	COG1388	LysM domain
H7R46_RS00645	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7R46_RS00665	COG3150	esterase
H7R46_RS00675	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H7R46_RS00685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R46_RS00695	COG2233	PERMEase
H7R46_RS00700	COG2351	hydroxyisourate hydrolase activity
H7R46_RS00735	COG3706	GGDEF domain
H7R46_RS00750	COG1393	Belongs to the ArsC family
H7R46_RS00755	COG0708	Exodeoxyribonuclease III
H7R46_RS00785	COG0189	ligase activity
H7R46_RS00805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7R46_RS00815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7R46_RS00830	COG4942	peptidase
H7R46_RS00840	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R46_RS00850	COG2119	membrane
H7R46_RS00855	COG4774	siderophore transport
H7R46_RS00860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7R46_RS00860	COG0426	domain, Protein
H7R46_RS00880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7R46_RS00900	COG1902	pentaerythritol trinitrate reductase activity
H7R46_RS00905	COG1519	Transferase
H7R46_RS00910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R46_RS00915	COG0668	transmembrane transport
H7R46_RS00925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R46_RS00930	COG1335	isochorismatase
H7R46_RS00935	COG1522	sequence-specific DNA binding
H7R46_RS00960	COG0784	Response regulator, receiver
H7R46_RS00960	COG2198	Histidine kinase
H7R46_RS00960	COG2205	protein histidine kinase activity
H7R46_RS00965	COG3162	membrane
H7R46_RS00970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R46_RS00980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7R46_RS01000	COG1309	transcriptional regulator
H7R46_RS01020	COG0300	oxidoreductase activity
H7R46_RS01025	COG0789	Transcriptional regulator
H7R46_RS01030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7R46_RS01030	COG0352	thiamine-phosphate diphosphorylase activity
H7R46_RS01030	COG0351	phosphomethylpyrimidine kinase
H7R46_RS01040	COG2814	Major facilitator Superfamily
H7R46_RS01055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H7R46_RS01065	COG1113	amino acid transport
H7R46_RS01075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7R46_RS01080	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS01090	COG1335	isochorismatase
H7R46_RS01120	COG2814	Major facilitator Superfamily
H7R46_RS01125	COG0583	DNA-binding transcription factor activity
H7R46_RS01145	COG0667	Aldo Keto reductase
H7R46_RS01180	COG1733	regulation of RNA biosynthetic process
H7R46_RS01185	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R46_RS01260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R46_RS01275	COG2329	Antibiotic biosynthesis monooxygenase
H7R46_RS01280	COG0697	spore germination
H7R46_RS01295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H7R46_RS01305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R46_RS01335	COG0427	acetyl-CoA hydrolase
H7R46_RS01360	COG0659	secondary active sulfate transmembrane transporter activity
H7R46_RS01365	COG4221	oxidoreductase activity
H7R46_RS01370	COG2873	o-acetylhomoserine
H7R46_RS01375	COG0488	(ABC) transporter
H7R46_RS01455	COG0833	amino acid
H7R46_RS01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R46_RS01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7R46_RS01520	COG2226	methyltransferase
H7R46_RS01570	COG0067	glutamate synthase
H7R46_RS01570	COG0069	glutamate synthase activity
H7R46_RS01570	COG0070	glutamate synthase
H7R46_RS01575	COG0493	'glutamate synthase
H7R46_RS01585	COG1704	LemA family
H7R46_RS01590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7R46_RS01610	COG3307	-O-antigen
H7R46_RS01635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R46_RS01650	COG0194	GDP metabolic process
H7R46_RS01700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7R46_RS01710	COG0335	large ribosomal subunit rRNA binding
H7R46_RS01720	COG5380	lipid catabolic process
H7R46_RS01725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7R46_RS01740	COG5006	permease, DMT superfamily
H7R46_RS01750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R46_RS01755	COG0277	FAD linked oxidase domain protein
H7R46_RS01765	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7R46_RS01770	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R46_RS01785	COG1289	transmembrane transporter activity
H7R46_RS01795	COG0628	permease
H7R46_RS01800	COG1192	Involved in chromosome partitioning
H7R46_RS01830	COG0833	amino acid
H7R46_RS01835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7R46_RS01840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R46_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS01890	COG0583	DNA-binding transcription factor activity
H7R46_RS01915	COG0752	glycyl-tRNA synthetase alpha subunit
H7R46_RS01940	COG0517	IMP dehydrogenase activity
H7R46_RS01940	COG0617	tRNA 3'-terminal CCA addition
H7R46_RS01940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R46_RS01945	COG1983	PspC domain protein
H7R46_RS01955	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS01970	COG0408	coproporphyrinogen oxidase activity
H7R46_RS01990	COG0513	Belongs to the DEAD box helicase family
H7R46_RS02000	COG1127	ABC transporter
H7R46_RS02005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7R46_RS02015	COG2854	intermembrane phospholipid transfer
H7R46_RS02025	COG0598	Magnesium transport protein CorA
H7R46_RS02035	COG0494	nUDIX hydrolase
H7R46_RS02040	COG1040	competence protein
H7R46_RS02045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7R46_RS02065	COG1946	Acyl-CoA thioesterase
H7R46_RS02070	COG1301	dicarboxylic acid transport
H7R46_RS02085	COG1959	2 iron, 2 sulfur cluster binding
H7R46_RS02090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R46_RS02090	COG1017	nitric oxide dioxygenase activity
H7R46_RS02100	COG0433	COG0433 Predicted ATPase
H7R46_RS02105	COG0626	cystathionine gamma-synthase activity
H7R46_RS02120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7R46_RS02125	COG0088	Forms part of the polypeptide exit tunnel
H7R46_RS02260	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS02265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7R46_RS02295	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7R46_RS02300	COG0339	signal peptide processing
H7R46_RS02305	COG0557	exoribonuclease II activity
H7R46_RS02355	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7R46_RS02360	COG1295	ribonuclease BN
H7R46_RS02395	COG1702	phosphate starvation-inducible protein PhoH
H7R46_RS02405	COG0741	lytic transglycosylase activity
H7R46_RS02405	COG0739	heme binding
H7R46_RS02405	COG1196	nuclear chromosome segregation
H7R46_RS02435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7R46_RS02440	COG1183	phosphatidylcholine synthase activity
H7R46_RS02485	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS02490	COG1309	transcriptional regulator
H7R46_RS02505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R46_RS02510	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS02550	COG2969	positive regulation of protein catabolic process
H7R46_RS02560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7R46_RS02565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7R46_RS02570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7R46_RS02575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7R46_RS02580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R46_RS02600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7R46_RS02610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R46_RS02615	COG1408	metallophosphoesterase
H7R46_RS02620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7R46_RS02620	COG2885	chlorophyll binding
H7R46_RS02625	COG2199	diguanylate cyclase activity
H7R46_RS02695	COG1607	acyl-coa hydrolase
H7R46_RS02730	COG2350	Protein conserved in bacteria
H7R46_RS02745	COG3781	membrane
H7R46_RS02755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7R46_RS02760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R46_RS02770	COG1862	Preprotein translocase
H7R46_RS02815	COG0784	Response regulator, receiver
H7R46_RS02815	COG5002	protein histidine kinase activity
H7R46_RS02815	COG2205	protein histidine kinase activity
H7R46_RS02820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7R46_RS02835	COG0726	polysaccharide deacetylase
H7R46_RS02850	COG1216	Glycosyl transferase, family 2
H7R46_RS02900	COG0625	glutathione transferase activity
H7R46_RS02905	COG0583	DNA-binding transcription factor activity
H7R46_RS02910	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS02915	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS02925	COG2205	protein histidine kinase activity
H7R46_RS02930	COG0745	RESPONSE REGULATOR receiver
H7R46_RS02940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7R46_RS02960	COG2096	Adenosyltransferase
H7R46_RS02965	COG4206	TonB-dependent receptor
H7R46_RS03010	COG0285	dihydrofolate synthase activity
H7R46_RS03030	COG0450	alkyl hydroperoxide reductase
H7R46_RS03045	COG0477	Major facilitator Superfamily
H7R46_RS03050	COG1272	protein, Hemolysin III
H7R46_RS03060	COG2153	protein acetylation
H7R46_RS03080	COG0183	Belongs to the thiolase family
H7R46_RS03085	COG2207	Transcriptional regulator
H7R46_RS03105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R46_RS03125	COG0183	Belongs to the thiolase family
H7R46_RS03135	COG2885	chlorophyll binding
H7R46_RS03135	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7R46_RS03145	COG1690	Belongs to the RtcB family
H7R46_RS03150	COG0833	amino acid
H7R46_RS03160	COG2233	PERMEase
H7R46_RS03165	COG1217	gtp-binding protein TYPA
H7R46_RS03190	COG2094	Belongs to the DNA glycosylase MPG family
H7R46_RS03195	COG4772	TonB-dependent receptor
H7R46_RS03200	COG1902	pentaerythritol trinitrate reductase activity
H7R46_RS03205	COG0679	Auxin Efflux Carrier
H7R46_RS03215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R46_RS03220	COG0354	folic acid binding
H7R46_RS03240	COG2233	PERMEase
H7R46_RS03245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7R46_RS03250	COG0251	oxidation-reduction process
H7R46_RS03255	COG1335	isochorismatase
H7R46_RS03260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R46_RS03265	COG0778	Nitroreductase
H7R46_RS03270	COG0596	Alpha beta hydrolase
H7R46_RS03275	COG3189	MarR family transcriptional regulator
H7R46_RS03280	COG2824	Alkylphosphonate utilization operon protein PhnA
H7R46_RS03285	COG3422	double-strand break repair
H7R46_RS03325	COG0840	transmembrane signaling receptor activity
H7R46_RS03350	COG5510	response to toxic substance
H7R46_RS03360	COG2832	Protein of unknown function (DUF454)
H7R46_RS03365	COG1376	ErfK ybiS ycfS ynhG family protein
H7R46_RS03405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R46_RS03415	COG1289	transmembrane transporter activity
H7R46_RS03420	COG2814	Major facilitator Superfamily
H7R46_RS03440	COG1115	amino acid carrier protein
H7R46_RS03445	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R46_RS03450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R46_RS03455	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H7R46_RS03460	COG3590	peptidase
H7R46_RS03485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7R46_RS03495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7R46_RS03500	COG1077	Cell shape determining protein MreB Mrl
H7R46_RS03505	COG1792	Involved in formation and maintenance of cell shape
H7R46_RS03510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7R46_RS03515	COG0424	maF-like protein
H7R46_RS03520	COG1530	ribonuclease E activity
H7R46_RS03530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R46_RS03550	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R46_RS03575	COG2207	Transcriptional regulator
H7R46_RS03590	COG3328	transposase activity
H7R46_RS03600	COG0464	growth
H7R46_RS03650	COG0305	Participates in initiation and elongation during chromosome replication
H7R46_RS03680	COG0582	viral genome integration into host DNA
H7R46_RS03700	COG3046	protein related to deoxyribodipyrimidine photolyase
H7R46_RS03710	COG1113	amino acid transport
H7R46_RS03715	COG2828	Protein conserved in bacteria
H7R46_RS03720	COG0142	geranyltranstransferase activity
H7R46_RS03725	COG2315	Protein conserved in bacteria
H7R46_RS03740	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R46_RS03765	COG2194	sulfuric ester hydrolase activity
H7R46_RS03770	COG0745	RESPONSE REGULATOR receiver
H7R46_RS03775	COG0642	Histidine kinase
H7R46_RS03785	COG0004	ammonium transporteR
H7R46_RS03790	COG0583	DNA-binding transcription factor activity
H7R46_RS03810	COG0525	valine-tRNA ligase activity
H7R46_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS03830	COG0393	Putative heavy-metal-binding
H7R46_RS03835	COG0393	Putative heavy-metal-binding
H7R46_RS03840	COG1538	Outer membrane efflux protein
H7R46_RS03850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R46_RS03855	COG0671	phosphoesterase, PA-phosphatase related
H7R46_RS03880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7R46_RS03895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R46_RS03895	COG1648	precorrin-2 dehydrogenase activity
H7R46_RS03900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7R46_RS03935	COG0531	amino acid
H7R46_RS03950	COG0321	lipoyl(octanoyl) transferase activity
H7R46_RS03955	COG2921	Belongs to the UPF0250 family
H7R46_RS03995	COG2009	succinate dehydrogenase
H7R46_RS04000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7R46_RS04005	COG1053	succinate dehydrogenase
H7R46_RS04010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7R46_RS04035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R46_RS04055	COG2354	Protein conserved in bacteria
H7R46_RS04060	COG2321	neutral zinc metallopeptidase
H7R46_RS04080	COG2843	Capsule synthesis protein
H7R46_RS04100	COG0589	response to stress
H7R46_RS04110	COG0251	oxidation-reduction process
H7R46_RS04115	COG1309	transcriptional regulator
H7R46_RS04130	COG0505	Belongs to the CarA family
H7R46_RS04160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R46_RS04165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7R46_RS04215	COG0477	Major facilitator Superfamily
H7R46_RS04220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7R46_RS04235	COG1597	lipid kinase activity
H7R46_RS04240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7R46_RS04270	COG0584	glycerophosphoryl diester phosphodiesterase
H7R46_RS04290	COG0741	lytic transglycosylase activity
H7R46_RS04310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R46_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS04330	COG0583	DNA-binding transcription factor activity
H7R46_RS04355	COG0406	alpha-ribazole phosphatase activity
H7R46_RS04375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R46_RS04385	COG0778	Nitroreductase
H7R46_RS04400	COG1929	Belongs to the glycerate kinase type-1 family
H7R46_RS04405	COG0243	molybdopterin cofactor binding
H7R46_RS04410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7R46_RS04425	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H7R46_RS04440	COG1115	amino acid carrier protein
H7R46_RS04445	COG1113	amino acid transport
H7R46_RS04455	COG0019	diaminopimelate decarboxylase activity
H7R46_RS04465	COG1280	lysine exporter protein (LysE YggA)
H7R46_RS04470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7R46_RS04500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R46_RS04530	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R46_RS04535	COG1136	(ABC) transporter
H7R46_RS04540	COG2333	competence protein COMEC
H7R46_RS04540	COG0658	competence protein
H7R46_RS04550	COG0616	signal peptide processing
H7R46_RS04550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R46_RS04555	COG0596	Alpha beta hydrolase
H7R46_RS04560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R46_RS04570	COG0628	permease
H7R46_RS04605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R46_RS04625	COG0823	Involved in the tonB-independent uptake of proteins
H7R46_RS04645	COG0824	Thioesterase
H7R46_RS04650	COG1473	amidohydrolase
H7R46_RS04670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7R46_RS04670	COG0047	phosphoribosylformylglycinamidine synthase activity
H7R46_RS04675	COG2814	Major facilitator Superfamily
H7R46_RS04680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R46_RS04685	COG1024	Enoyl-CoA hydratase
H7R46_RS04690	COG1051	belongs to the nudix hydrolase family
H7R46_RS04690	COG1056	cytidyltransferase-related domain
H7R46_RS04705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7R46_RS04720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7R46_RS04735	COG4625	pathogenesis
H7R46_RS04740	COG0583	DNA-binding transcription factor activity
H7R46_RS04745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7R46_RS04750	COG4208	sulfate ABC transporter
H7R46_RS04755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7R46_RS04765	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7R46_RS04770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7R46_RS04775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7R46_RS04795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R46_RS04805	COG0481	GTPase activity
H7R46_RS04810	COG0681	Belongs to the peptidase S26 family
H7R46_RS04820	COG0571	ribonuclease III activity
H7R46_RS04825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7R46_RS04835	COG1381	Involved in DNA repair and RecF pathway recombination
H7R46_RS04840	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7R46_RS04850	COG4221	oxidoreductase activity
H7R46_RS04880	COG0436	Aminotransferase
H7R46_RS04900	COG0556	nucleotide-excision repair
H7R46_RS04910	COG2962	Rard protein
H7R46_RS04955	COG2070	2-Nitropropane dioxygenase
H7R46_RS04970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7R46_RS04985	COG1215	transferase activity, transferring glycosyl groups
H7R46_RS05000	COG0415	Belongs to the DNA photolyase family
H7R46_RS05010	COG1252	NADH dehydrogenase
H7R46_RS05015	COG1686	Belongs to the peptidase S11 family
H7R46_RS05030	COG1187	pseudouridine synthase activity
H7R46_RS05045	COG0477	Major facilitator Superfamily
H7R46_RS05050	COG0583	DNA-binding transcription factor activity
H7R46_RS05055	COG1823	symporter activity
H7R46_RS05065	COG0612	Peptidase, M16
H7R46_RS05090	COG0352	thiamine-phosphate diphosphorylase activity
H7R46_RS05125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R46_RS05140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7R46_RS05145	COG0076	glutamate decarboxylase activity
H7R46_RS05155	COG1522	sequence-specific DNA binding
H7R46_RS05160	COG3961	Belongs to the TPP enzyme family
H7R46_RS05165	COG1113	amino acid transport
H7R46_RS05170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7R46_RS05175	COG0573	inorganic phosphate transmembrane transporter activity
H7R46_RS05185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7R46_RS05190	COG0616	signal peptide processing
H7R46_RS05230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R46_RS05235	COG1686	Belongs to the peptidase S11 family
H7R46_RS05260	COG0583	DNA-binding transcription factor activity
H7R46_RS05265	COG1067	ATP-dependent peptidase activity
H7R46_RS05270	COG2211	Major facilitator Superfamily
H7R46_RS05305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7R46_RS05310	COG1966	Carbon starvation protein
H7R46_RS05315	COG2879	small protein
H7R46_RS05340	COG1741	Belongs to the pirin family
H7R46_RS05355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R46_RS05360	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R46_RS05365	COG4605	iron ion homeostasis
H7R46_RS05370	COG4604	ABC transporter, ATP-binding protein
H7R46_RS05375	COG4607	ABC-type enterochelin transport system periplasmic component
H7R46_RS05380	COG4774	siderophore transport
H7R46_RS05390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R46_RS05395	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7R46_RS05400	COG1535	isochorismatase
H7R46_RS05400	COG3433	isochorismatase activity
H7R46_RS05410	COG1132	(ABC) transporter
H7R46_RS05415	COG1132	(ABC) transporter
H7R46_RS05420	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H7R46_RS05425	COG2977	Belongs to the P-Pant transferase superfamily
H7R46_RS05430	COG1169	isochorismate synthase
H7R46_RS05445	COG3739	integral membrane protein
H7R46_RS05465	COG0302	gtp cyclohydrolase
H7R46_RS05475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R46_RS05485	COG2840	Smr protein MutS2
H7R46_RS05510	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R46_RS05525	COG0174	glutamine synthetase
H7R46_RS05535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7R46_RS05570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7R46_RS05575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R46_RS05580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R46_RS05600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R46_RS05605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7R46_RS05610	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7R46_RS05625	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS05630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R46_RS05635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R46_RS05645	COG2223	nitrite transmembrane transporter activity
H7R46_RS05655	COG0024	Methionine aminopeptidase
H7R46_RS05660	COG0052	Belongs to the universal ribosomal protein uS2 family
H7R46_RS05675	COG2207	Transcriptional regulator
H7R46_RS05700	COG2951	lytic endotransglycosylase activity
H7R46_RS05705	COG0772	Belongs to the SEDS family
H7R46_RS05720	COG0842	Transport permease protein
H7R46_RS05725	COG1131	(ABC) transporter
H7R46_RS05770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R46_RS05780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R46_RS05785	COG4215	(ABC) transporter
H7R46_RS05790	COG4160	amino acid transport
H7R46_RS05795	COG4598	ABC transporter
H7R46_RS05805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R46_RS05810	COG0826	peptidase U32
H7R46_RS05815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R46_RS05820	COG0384	phenazine biosynthesis protein PhzF
H7R46_RS05830	COG1720	tRNA m6t6A37 methyltransferase activity
H7R46_RS05840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R46_RS05855	COG0642	Histidine kinase
H7R46_RS05865	COG0494	nUDIX hydrolase
H7R46_RS05875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R46_RS05880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7R46_RS05885	COG3139	Protein of unknown function (DUF1315)
H7R46_RS05890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R46_RS05895	COG1301	dicarboxylic acid transport
H7R46_RS05900	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS05915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7R46_RS05925	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R46_RS05930	COG1234	tRNA 3'-trailer cleavage
H7R46_RS05955	COG2363	Small membrane protein
H7R46_RS05975	COG0513	Belongs to the DEAD box helicase family
H7R46_RS05985	COG0778	Nitroreductase
H7R46_RS06015	COG1286	toxin biosynthetic process
H7R46_RS06040	COG4783	chaperone-mediated protein folding
H7R46_RS06045	COG1610	YqeY-like protein
H7R46_RS06075	COG2815	serine threonine protein kinase
H7R46_RS06075	COG0515	serine threonine protein kinase
H7R46_RS06100	COG1278	Cold shock
H7R46_RS06115	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7R46_RS06120	COG0786	glutamate:sodium symporter activity
H7R46_RS06155	COG2985	domain, Protein
H7R46_RS06165	COG2995	paraquat-inducible protein a
H7R46_RS06170	COG3008	intermembrane lipid transfer
H7R46_RS06170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R46_RS06195	COG2351	hydroxyisourate hydrolase activity
H7R46_RS06235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R46_RS06245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R46_RS06250	COG0642	Histidine kinase
H7R46_RS06255	COG0745	RESPONSE REGULATOR receiver
H7R46_RS06270	COG1794	racemase activity, acting on amino acids and derivatives
H7R46_RS06280	COG2175	clavaminate synthase activity
H7R46_RS06285	COG3246	L-lysine catabolic process to acetate
H7R46_RS06290	COG2814	Major facilitator Superfamily
H7R46_RS06305	COG2855	membrane
H7R46_RS06340	COG2814	Major facilitator Superfamily
H7R46_RS06365	COG1301	dicarboxylic acid transport
H7R46_RS06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R46_RS06380	COG2011	ABC-type metal ion transport system permease component
H7R46_RS06385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R46_RS06395	COG0151	Belongs to the GarS family
H7R46_RS06405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7R46_RS06435	COG2308	Evidence 4 Homologs of previously reported genes of
H7R46_RS06445	COG1305	Transglutaminase-like
H7R46_RS06455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R46_RS06460	COG0305	Participates in initiation and elongation during chromosome replication
H7R46_RS06485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7R46_RS06490	COG1845	cytochrome c oxidase, subunit III
H7R46_RS06495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7R46_RS06525	COG1649	PFAM Uncharacterised BCR, COG1649
H7R46_RS06525	COG0726	polysaccharide deacetylase
H7R46_RS06530	COG1215	transferase activity, transferring glycosyl groups
H7R46_RS06535	COG3658	cytochrome
H7R46_RS06545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R46_RS06560	COG0583	DNA-binding transcription factor activity
H7R46_RS06575	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R46_RS06580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7R46_RS06585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7R46_RS06600	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS06605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7R46_RS06620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7R46_RS06630	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7R46_RS06635	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7R46_RS06645	COG2205	protein histidine kinase activity
H7R46_RS06650	COG0745	RESPONSE REGULATOR receiver
H7R46_RS06655	COG0174	glutamine synthetase
H7R46_RS06670	COG0477	Major facilitator Superfamily
H7R46_RS06675	COG0729	surface antigen
H7R46_RS06705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R46_RS06710	COG2814	Major facilitator Superfamily
H7R46_RS06725	COG0583	DNA-binding transcription factor activity
H7R46_RS06740	COG1187	pseudouridine synthase activity
H7R46_RS06755	COG0564	pseudouridine synthase activity
H7R46_RS06760	COG0802	atpase or kinase
H7R46_RS06765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R46_RS06775	COG1923	regulation of RNA biosynthetic process
H7R46_RS06780	COG0697	spore germination
H7R46_RS06795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R46_RS06805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R46_RS06810	COG0519	Catalyzes the synthesis of GMP from XMP
H7R46_RS06810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R46_RS06815	COG4302	ethanolamine ammonia-lyase activity
H7R46_RS06820	COG4303	Ethanolamine ammonia lyase large subunit
H7R46_RS06825	COG0531	amino acid
H7R46_RS06845	COG1454	alcohol dehydrogenase
H7R46_RS06850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R46_RS06880	COG0308	aminopeptidase N
H7R46_RS06920	COG1605	Chorismate mutase
H7R46_RS06935	COG4772	TonB-dependent receptor
H7R46_RS06940	COG4774	siderophore transport
H7R46_RS06995	COG3772	lysozyme
H7R46_RS07020	COG0583	DNA-binding transcription factor activity
H7R46_RS07055	COG0488	(ABC) transporter
H7R46_RS07060	COG0589	response to stress
H7R46_RS07080	COG3135	benzoate transporter
H7R46_RS07085	COG1522	sequence-specific DNA binding
H7R46_RS07095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R46_RS07100	COG0583	DNA-binding transcription factor activity
H7R46_RS07110	COG0183	Belongs to the thiolase family
H7R46_RS07120	COG2030	dehydratase
H7R46_RS07125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7R46_RS07150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7R46_RS07160	COG0824	Thioesterase
H7R46_RS07165	COG1454	alcohol dehydrogenase
H7R46_RS07190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7R46_RS07220	COG0069	glutamate synthase activity
H7R46_RS07250	COG2814	Major facilitator Superfamily
H7R46_RS07265	COG0511	ligase activity, forming carbon-carbon bonds
H7R46_RS07290	COG4264	IucA IucC family
H7R46_RS07300	COG4264	IucA IucC family
H7R46_RS07305	COG2423	ornithine cyclodeaminase activity
H7R46_RS07310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R46_RS07315	COG1116	anion transmembrane transporter activity
H7R46_RS07315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7R46_RS07330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R46_RS07330	COG2146	nitrite reductase [NAD(P)H] activity
H7R46_RS07335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R46_RS07340	COG0243	molybdopterin cofactor binding
H7R46_RS07350	COG0243	molybdopterin cofactor binding
H7R46_RS07355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7R46_RS07370	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R46_RS07370	COG0315	cyclic pyranopterin monophosphate synthase activity
H7R46_RS07375	COG0303	'Molybdopterin
H7R46_RS07385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R46_RS07390	COG0697	spore germination
H7R46_RS07415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R46_RS07480	COG2204	response regulator
H7R46_RS07485	COG3852	Histidine kinase
H7R46_RS07510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7R46_RS07515	COG0575	Belongs to the CDS family
H7R46_RS07550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R46_RS07565	COG2137	regulation of response to DNA damage stimulus
H7R46_RS07575	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7R46_RS07580	COG1011	Hydrolase
H7R46_RS07595	COG1522	sequence-specific DNA binding
H7R46_RS07605	COG1113	amino acid transport
H7R46_RS07625	COG0659	secondary active sulfate transmembrane transporter activity
H7R46_RS07675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7R46_RS07675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R46_RS07675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R46_RS07680	COG1105	Belongs to the carbohydrate kinase PfkB family
H7R46_RS07685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R46_RS07685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R46_RS07705	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H7R46_RS07715	COG0024	Methionine aminopeptidase
H7R46_RS07720	COG0583	DNA-binding transcription factor activity
H7R46_RS07730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7R46_RS07735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R46_RS07740	COG0517	IMP dehydrogenase activity
H7R46_RS07740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7R46_RS07765	COG0552	protein localization to endoplasmic reticulum
H7R46_RS07775	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H7R46_RS07790	COG4890	Cyd operon protein YbgT
H7R46_RS07795	COG1294	oxidase, subunit
H7R46_RS07810	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7R46_RS07820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R46_RS07835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R46_RS07840	COG0569	domain protein
H7R46_RS07845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R46_RS07875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7R46_RS07880	COG0542	response to heat
H7R46_RS07905	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R46_RS07905	COG1902	pentaerythritol trinitrate reductase activity
H7R46_RS07945	COG0148	phosphopyruvate hydratase activity
H7R46_RS07950	COG2323	membrane
H7R46_RS07960	COG4773	Receptor
H7R46_RS07965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7R46_RS07975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7R46_RS07980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7R46_RS07985	COG0183	Belongs to the thiolase family
H7R46_RS07990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7R46_RS07995	COG0596	Alpha beta hydrolase
H7R46_RS08000	COG2271	Major facilitator Superfamily
H7R46_RS08005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R46_RS08010	COG3485	protocatechuate 3,4-dioxygenase
H7R46_RS08015	COG3485	protocatechuate 3,4-dioxygenase
H7R46_RS08020	COG0710	3-dehydroquinate dehydratase activity
H7R46_RS08025	COG3420	alginic acid biosynthetic process
H7R46_RS08030	COG3659	wide pore channel activity
H7R46_RS08035	COG4993	Dehydrogenase
H7R46_RS08045	COG2391	methyltransferase activity
H7R46_RS08060	COG1414	Transcriptional regulator
H7R46_RS08065	COG0583	DNA-binding transcription factor activity
H7R46_RS08070	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS08095	COG2814	Major facilitator Superfamily
H7R46_RS08105	COG0154	amidase activity
H7R46_RS08125	COG4638	Rieske (2fe-2S)
H7R46_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS08145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7R46_RS08165	COG3733	amine oxidase
H7R46_RS08175	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS08180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7R46_RS08185	COG0183	Belongs to the thiolase family
H7R46_RS08190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7R46_RS08195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7R46_RS08205	COG4829	muconolactone delta-isomerase
H7R46_RS08210	COG4948	Mandelate Racemase Muconate Lactonizing
H7R46_RS08215	COG0583	DNA-binding transcription factor activity
H7R46_RS08225	COG2186	Transcriptional regulator
H7R46_RS08245	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS08250	COG2351	hydroxyisourate hydrolase activity
H7R46_RS08255	COG2233	PERMEase
H7R46_RS08265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R46_RS08270	COG2186	Transcriptional regulator
H7R46_RS08280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7R46_RS08290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7R46_RS08310	COG1902	pentaerythritol trinitrate reductase activity
H7R46_RS08310	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R46_RS08350	COG1309	transcriptional regulator
H7R46_RS08355	COG0583	DNA-binding transcription factor activity
H7R46_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS08380	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS08390	COG0318	PFAM AMP-dependent synthetase and ligase
H7R46_RS08415	COG0583	DNA-binding transcription factor activity
H7R46_RS08440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R46_RS08445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R46_RS08495	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS08500	COG0129	dihydroxy-acid dehydratase activity
H7R46_RS08510	COG0583	DNA-binding transcription factor activity
H7R46_RS08515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R46_RS08525	COG2084	Dehydrogenase
H7R46_RS08540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R46_RS08545	COG1120	ATPase activity
H7R46_RS08565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R46_RS08615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7R46_RS08640	COG2856	Zn peptidase
H7R46_RS08690	COG3539	Fimbrial protein
H7R46_RS08715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7R46_RS08725	COG0753	catalase activity
H7R46_RS08745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R46_RS08755	COG2205	protein histidine kinase activity
H7R46_RS08760	COG0745	RESPONSE REGULATOR receiver
H7R46_RS08765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R46_RS08770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R46_RS08825	COG3433	isochorismatase activity
H7R46_RS08825	COG1535	isochorismatase
H7R46_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS08835	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7R46_RS08840	COG4149	molybdate abc transporter
H7R46_RS08845	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7R46_RS08855	COG4638	Rieske (2fe-2S)
H7R46_RS08860	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H7R46_RS08865	COG0543	2 iron, 2 sulfur cluster binding
H7R46_RS08865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R46_RS08880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7R46_RS08890	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS08905	COG2207	Transcriptional regulator
H7R46_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS08915	COG2610	gluconate transmembrane transporter activity
H7R46_RS08955	COG0583	DNA-binding transcription factor activity
H7R46_RS08970	COG2031	fatty acid transporter
H7R46_RS08975	COG0183	Belongs to the thiolase family
H7R46_RS08980	COG0583	DNA-binding transcription factor activity
H7R46_RS08985	COG0583	DNA-binding transcription factor activity
H7R46_RS09000	COG1027	Aspartate ammonia-lyase
H7R46_RS09010	COG0477	Major facilitator Superfamily
H7R46_RS09020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R46_RS09025	COG1733	regulation of RNA biosynthetic process
H7R46_RS09030	COG3708	Transcriptional regulator
H7R46_RS09030	COG2207	Transcriptional regulator
H7R46_RS09045	COG0730	response to heat
H7R46_RS09065	COG3781	membrane
H7R46_RS09070	COG1063	alcohol dehydrogenase
H7R46_RS09080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R46_RS09085	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R46_RS09090	COG0022	dehydrogenase e1 component
H7R46_RS09095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7R46_RS09100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R46_RS09115	COG3706	GGDEF domain
H7R46_RS09135	COG0133	tryptophan synthase activity
H7R46_RS09145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R46_RS09175	COG0583	DNA-binding transcription factor activity
H7R46_RS09180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R46_RS09190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7R46_RS09250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R46_RS09255	COG4773	Receptor
H7R46_RS09275	COG0730	response to heat
H7R46_RS09280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R46_RS09300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7R46_RS09315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R46_RS09325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7R46_RS09340	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS09345	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS09350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R46_RS09355	COG2207	Transcriptional regulator
H7R46_RS09360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R46_RS09365	COG0776	regulation of translation
H7R46_RS09390	COG0822	iron-sulfur transferase activity
H7R46_RS09395	COG0316	Belongs to the HesB IscA family
H7R46_RS09425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7R46_RS09445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R46_RS09450	COG0702	epimerase
H7R46_RS09495	COG0339	signal peptide processing
H7R46_RS09500	COG4166	transmembrane transport
H7R46_RS09545	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7R46_RS09550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7R46_RS09565	COG2431	L-lysine efflux transmembrane transporter activity
H7R46_RS09580	COG0776	regulation of translation
H7R46_RS09645	COG0084	hydrolase, TatD family'
H7R46_RS09665	COG1663	tetraacyldisaccharide 4'-kinase activity
H7R46_RS09670	COG1132	(ABC) transporter
H7R46_RS09680	COG0811	peptide transport
H7R46_RS09685	COG1475	DNA binding
H7R46_RS09690	COG1192	Involved in chromosome partitioning
H7R46_RS09700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R46_RS09705	COG3178	'Phosphotransferase
H7R46_RS09715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R46_RS09740	COG0424	maF-like protein
H7R46_RS09745	COG2850	peptidyl-arginine hydroxylation
H7R46_RS09755	COG0640	Transcriptional regulator
H7R46_RS09765	COG3619	membrane
H7R46_RS09775	COG3122	Protein conserved in bacteria
H7R46_RS09780	COG1132	(ABC) transporter
H7R46_RS09800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7R46_RS09805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R46_RS09815	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7R46_RS09815	COG0506	proline dehydrogenase activity
H7R46_RS09815	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7R46_RS09820	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7R46_RS09835	COG3698	Phosphodiester glycosidase
H7R46_RS09845	COG2353	YceI-like domain
H7R46_RS09855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7R46_RS09900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7R46_RS09900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7R46_RS09925	COG3539	Fimbrial protein
H7R46_RS09955	COG0583	DNA-binding transcription factor activity
H7R46_RS09960	COG0697	spore germination
H7R46_RS09970	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7R46_RS09980	COG0583	DNA-binding transcription factor activity
H7R46_RS09995	COG1309	transcriptional regulator
H7R46_RS10010	COG1522	sequence-specific DNA binding
H7R46_RS10020	COG1126	abc transporter atp-binding protein
H7R46_RS10025	COG0765	amino acid transport
H7R46_RS10030	COG0765	amino acid transport
H7R46_RS10060	COG1464	Belongs to the NlpA lipoprotein family
H7R46_RS10070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R46_RS10075	COG2011	ABC-type metal ion transport system permease component
H7R46_RS10080	COG0012	GTP binding
H7R46_RS10105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H7R46_RS10140	COG2207	Transcriptional regulator
H7R46_RS10140	COG1917	Cupin 2, conserved barrel domain protein
H7R46_RS10145	COG0386	Belongs to the glutathione peroxidase family
H7R46_RS10155	COG0436	Aminotransferase
H7R46_RS10160	COG1301	dicarboxylic acid transport
H7R46_RS10195	COG3634	alkyl hydroperoxide reductase activity
H7R46_RS10210	COG0583	DNA-binding transcription factor activity
H7R46_RS10215	COG0431	NADPH-dependent FMN reductase
H7R46_RS10220	COG0798	PFAM Bile acid sodium symporter
H7R46_RS10245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7R46_RS10255	COG0583	DNA-binding transcription factor activity
H7R46_RS10265	COG1953	Uracil, thiamine, allantoin
H7R46_RS10275	COG2175	clavaminate synthase activity
H7R46_RS10280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7R46_RS10285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7R46_RS10290	COG4521	taurine ABC transporter
H7R46_RS10300	COG0477	Major facilitator Superfamily
H7R46_RS10320	COG1271	oxidase subunit
H7R46_RS10325	COG1294	oxidase, subunit
H7R46_RS10335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R46_RS10355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7R46_RS10375	COG3052	prosthetic group binding
H7R46_RS10380	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H7R46_RS10390	COG0583	DNA-binding transcription factor activity
H7R46_RS10395	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS10400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R46_RS10410	COG2814	Major facilitator Superfamily
H7R46_RS10415	COG0300	oxidoreductase activity
H7R46_RS10440	COG1346	cytolysis
H7R46_RS10450	COG0583	DNA-binding transcription factor activity
H7R46_RS10455	COG0625	glutathione transferase activity
H7R46_RS10460	COG0625	glutathione transferase activity
H7R46_RS10480	COG0583	DNA-binding transcription factor activity
H7R46_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS10495	COG1045	serine acetyltransferase
H7R46_RS10500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R46_RS10505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7R46_RS10510	COG1280	lysine exporter protein (LysE YggA)
H7R46_RS10525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R46_RS10530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R46_RS10540	COG0765	amino acid transport
H7R46_RS10545	COG0765	amino acid transport
H7R46_RS10565	COG0784	Response regulator, receiver
H7R46_RS10565	COG2205	protein histidine kinase activity
H7R46_RS10585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R46_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS10650	COG0583	DNA-binding transcription factor activity
H7R46_RS10660	COG2814	Major facilitator Superfamily
H7R46_RS10675	COG0318	PFAM AMP-dependent synthetase and ligase
H7R46_RS10680	COG3328	transposase activity
H7R46_RS10690	COG1309	transcriptional regulator
H7R46_RS10695	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS10700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R46_RS10705	COG1024	Enoyl-CoA hydratase
H7R46_RS10710	COG4770	biotin carboxylase activity
H7R46_RS10720	COG0583	DNA-binding transcription factor activity
H7R46_RS10735	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS10745	COG2814	Major facilitator Superfamily
H7R46_RS10755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7R46_RS10760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7R46_RS10765	COG2814	Major facilitator Superfamily
H7R46_RS10770	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS10775	COG1024	Enoyl-CoA hydratase
H7R46_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS10785	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R46_RS10790	COG0183	Belongs to the thiolase family
H7R46_RS10810	COG1024	Enoyl-CoA hydratase
H7R46_RS10820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7R46_RS10825	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS10830	COG2814	Major facilitator Superfamily
H7R46_RS10835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R46_RS10840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7R46_RS10855	COG3842	ATPase activity
H7R46_RS10860	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R46_RS10875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R46_RS10880	COG1414	Transcriptional regulator
H7R46_RS10890	COG0583	DNA-binding transcription factor activity
H7R46_RS10915	COG2050	protein possibly involved in aromatic compounds catabolism
H7R46_RS10925	COG3327	negative regulation of DNA-templated transcription, initiation
H7R46_RS10930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H7R46_RS10935	COG0183	Belongs to the thiolase family
H7R46_RS10940	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R46_RS10945	COG1024	Enoyl-CoA hydratase
H7R46_RS10950	COG1024	Enoyl-CoA hydratase
H7R46_RS10955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R46_RS10960	COG2151	metal-sulfur cluster biosynthetic enzyme
H7R46_RS10965	COG3396	Phenylacetate-CoA oxygenase
H7R46_RS10970	COG3460	Phenylacetate-CoA oxygenase
H7R46_RS10975	COG3396	Phenylacetate-CoA oxygenase
H7R46_RS10980	COG2030	dehydratase
H7R46_RS10980	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS10985	COG1760	l-serine dehydratase
H7R46_RS11000	COG0789	Transcriptional regulator
H7R46_RS11010	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7R46_RS11015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R46_RS11030	COG2807	transmembrane transport
H7R46_RS11090	COG1116	anion transmembrane transporter activity
H7R46_RS11105	COG0864	Transcriptional regulator
H7R46_RS11115	COG1733	regulation of RNA biosynthetic process
H7R46_RS11120	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R46_RS11125	COG0439	Biotin carboxylase
H7R46_RS11140	COG1063	alcohol dehydrogenase
H7R46_RS11145	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R46_RS11165	COG3328	transposase activity
H7R46_RS11195	COG2831	hemolysin activation secretion protein
H7R46_RS11200	COG0038	chloride channel
H7R46_RS11205	COG4770	biotin carboxylase activity
H7R46_RS11225	COG1914	H( )-stimulated, divalent metal cation uptake system
H7R46_RS11230	COG0583	DNA-binding transcription factor activity
H7R46_RS11240	COG1595	DNA-templated transcription, initiation
H7R46_RS11250	COG3220	belongs to the UPF0276 family
H7R46_RS11300	COG0702	epimerase
H7R46_RS11305	COG1733	regulation of RNA biosynthetic process
H7R46_RS11320	COG1051	belongs to the nudix hydrolase family
H7R46_RS11335	COG1595	DNA-templated transcription, initiation
H7R46_RS11340	COG3712	iron ion homeostasis
H7R46_RS11385	COG3038	cytochrome b561
H7R46_RS11390	COG0753	catalase activity
H7R46_RS11395	COG1733	regulation of RNA biosynthetic process
H7R46_RS11405	COG1469	GTP cyclohydrolase I activity
H7R46_RS11410	COG4451	ribulose bisphosphate carboxylase, small
H7R46_RS11410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R46_RS11415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7R46_RS11430	COG1522	sequence-specific DNA binding
H7R46_RS11435	COG0531	amino acid
H7R46_RS11440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R46_RS11455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7R46_RS11470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7R46_RS11480	COG4122	O-methyltransferase activity
H7R46_RS11490	COG0110	maltose O-acetyltransferase activity
H7R46_RS11510	COG1137	ATPase activity
H7R46_RS11515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7R46_RS11525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7R46_RS11560	COG0668	transmembrane transport
H7R46_RS11605	COG1309	transcriptional regulator
H7R46_RS11620	COG2226	methyltransferase
H7R46_RS11645	COG1278	Cold shock
H7R46_RS11650	COG1560	Kdo2-lipid A biosynthetic process
H7R46_RS11655	COG1280	lysine exporter protein (LysE YggA)
H7R46_RS11690	COG1570	exodeoxyribonuclease VII activity
H7R46_RS11775	COG2871	sodium ion transport
H7R46_RS11785	COG0583	DNA-binding transcription factor activity
H7R46_RS11795	COG4638	Rieske (2fe-2S)
H7R46_RS11800	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H7R46_RS11805	COG0543	2 iron, 2 sulfur cluster binding
H7R46_RS11805	COG0633	Ferredoxin
H7R46_RS11810	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS11815	COG3135	benzoate transporter
H7R46_RS11820	COG2814	Major facilitator Superfamily
H7R46_RS11835	COG1643	Atp-dependent helicase
H7R46_RS11860	COG3634	alkyl hydroperoxide reductase activity
H7R46_RS11880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7R46_RS11890	COG0625	glutathione transferase activity
H7R46_RS11900	COG2885	chlorophyll binding
H7R46_RS11935	COG0542	response to heat
H7R46_RS11950	COG1765	OsmC-like protein
H7R46_RS11965	COG0667	Aldo Keto reductase
H7R46_RS11980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7R46_RS11990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R46_RS12000	COG0582	viral genome integration into host DNA
H7R46_RS12005	COG2194	sulfuric ester hydrolase activity
H7R46_RS12050	COG1196	nuclear chromosome segregation
H7R46_RS12050	COG0741	lytic transglycosylase activity
H7R46_RS12050	COG0739	heme binding
H7R46_RS12065	COG1598	PFAM Uncharacterised protein family UPF0150
H7R46_RS12175	COG0527	aspartate kinase activity
H7R46_RS12185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7R46_RS12195	COG3038	cytochrome b561
H7R46_RS12200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R46_RS12205	COG2252	PERMEase
H7R46_RS12215	COG1741	Belongs to the pirin family
H7R46_RS12220	COG1309	transcriptional regulator
H7R46_RS12235	COG2072	flavoprotein involved in K transport
H7R46_RS12240	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7R46_RS12270	COG1944	ATP diphosphatase activity
H7R46_RS12290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7R46_RS12305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R46_RS12320	COG2814	Major facilitator Superfamily
H7R46_RS12325	COG1024	Enoyl-CoA hydratase
H7R46_RS12330	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS12340	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS12365	COG2186	Transcriptional regulator
H7R46_RS12370	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS12380	COG4948	Mandelate Racemase Muconate Lactonizing
H7R46_RS12385	COG2271	Major facilitator Superfamily
H7R46_RS12390	COG2721	sulfolactate sulfo-lyase activity
H7R46_RS12395	COG0697	spore germination
H7R46_RS12420	COG1113	amino acid transport
H7R46_RS12455	COG4269	membrane
H7R46_RS12470	COG0582	viral genome integration into host DNA
H7R46_RS12495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R46_RS12525	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R46_RS12595	COG0789	Transcriptional regulator
H7R46_RS12650	COG2059	Chromate
H7R46_RS12660	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H7R46_RS12670	COG1230	cation diffusion facilitator family transporter
H7R46_RS12685	COG2814	Major facilitator Superfamily
H7R46_RS12800	COG0582	viral genome integration into host DNA
H7R46_RS12810	COG1902	pentaerythritol trinitrate reductase activity
H7R46_RS12810	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R46_RS12820	COG2203	Gaf domain
H7R46_RS12820	COG3706	GGDEF domain
H7R46_RS12820	COG4251	negative regulation of phosphorylation
H7R46_RS12820	COG5001	Diguanylate cyclase
H7R46_RS12830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R46_RS12855	COG4172	Belongs to the ABC transporter superfamily
H7R46_RS12860	COG4239	(ABC) transporter, permease
H7R46_RS12865	COG4174	ABC transporter (Permease)
H7R46_RS12870	COG4166	transmembrane transport
H7R46_RS12875	COG0741	lytic transglycosylase activity
H7R46_RS12875	COG1388	LysM domain
H7R46_RS12915	COG0583	DNA-binding transcription factor activity
H7R46_RS12920	COG1279	arginine transmembrane transporter activity
H7R46_RS12930	COG0789	Transcriptional regulator
H7R46_RS12940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R46_RS12945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R46_RS12950	COG0006	proline dipeptidase activity
H7R46_RS12990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7R46_RS13005	COG3384	dioxygenase
H7R46_RS13015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7R46_RS13020	COG2878	Part of a membrane complex involved in electron transport
H7R46_RS13025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7R46_RS13050	COG0768	penicillin binding
H7R46_RS13055	COG0742	ribosomal rna small subunit methyltransferase
H7R46_RS13070	COG0830	nickel cation binding
H7R46_RS13080	COG0804	urea catabolic process
H7R46_RS13110	COG3015	lipoprotein NlpE involved in copper resistance
H7R46_RS13125	COG1253	flavin adenine dinucleotide binding
H7R46_RS13130	COG2851	Citrate transporter
H7R46_RS13180	COG1773	rubredoxin
H7R46_RS13185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R46_RS13190	COG0596	Alpha beta hydrolase
H7R46_RS13195	COG0583	DNA-binding transcription factor activity
H7R46_RS13225	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7R46_RS13230	COG4181	ATPase activity
H7R46_RS13275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7R46_RS13295	COG0306	phosphate transporter
H7R46_RS13315	COG3958	Transketolase
H7R46_RS13320	COG3959	Transketolase, thiamine diphosphate binding domain
H7R46_RS13325	COG2271	Major facilitator Superfamily
H7R46_RS13335	COG0583	DNA-binding transcription factor activity
H7R46_RS13350	COG2223	nitrite transmembrane transporter activity
H7R46_RS13355	COG2207	Transcriptional regulator
H7R46_RS13360	COG2066	Belongs to the glutaminase family
H7R46_RS13365	COG0242	peptide deformylase activity
H7R46_RS13370	COG0477	Major facilitator Superfamily
H7R46_RS13380	COG0028	Belongs to the TPP enzyme family
H7R46_RS13395	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS13400	COG2267	carboxylic ester hydrolase activity
H7R46_RS13410	COG2271	Major facilitator Superfamily
H7R46_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS13445	COG1414	Transcriptional regulator
H7R46_RS13460	COG1024	Enoyl-CoA hydratase
H7R46_RS13470	COG1215	transferase activity, transferring glycosyl groups
H7R46_RS13475	COG0726	polysaccharide deacetylase
H7R46_RS13475	COG1649	PFAM Uncharacterised BCR, COG1649
H7R46_RS13485	COG4681	YaeQ
H7R46_RS13495	COG0523	cobalamin synthesis protein
H7R46_RS13505	COG1607	acyl-coa hydrolase
H7R46_RS13515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7R46_RS13520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7R46_RS13525	COG1309	transcriptional regulator
H7R46_RS13550	COG2040	homocysteine
H7R46_RS13555	COG0531	amino acid
H7R46_RS13605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R46_RS13610	COG0477	Major facilitator Superfamily
H7R46_RS13650	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H7R46_RS13750	COG1196	nuclear chromosome segregation
H7R46_RS13750	COG0741	lytic transglycosylase activity
H7R46_RS13750	COG0739	heme binding
H7R46_RS13760	COG1598	PFAM Uncharacterised protein family UPF0150
H7R46_RS14075	COG2814	Major facilitator Superfamily
H7R46_RS14085	COG2050	protein possibly involved in aromatic compounds catabolism
H7R46_RS14100	COG1090	epimerase
H7R46_RS14120	COG0420	3'-5' exonuclease activity
H7R46_RS14145	COG0735	belongs to the Fur family
H7R46_RS14150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R46_RS14155	COG2914	Belongs to the UPF0125 (RnfH) family
H7R46_RS14170	COG0121	glutamine amidotransferase
H7R46_RS14185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R46_RS14195	COG0210	DNA helicase
H7R46_RS14200	COG2885	chlorophyll binding
H7R46_RS14205	COG0204	Acyl-transferase
H7R46_RS14220	COG2894	cell division
H7R46_RS14235	COG1280	lysine exporter protein (LysE YggA)
H7R46_RS14240	COG1674	ftsk spoiiie
H7R46_RS14245	COG0492	ferredoxin-NADP+ reductase activity
H7R46_RS14250	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7R46_RS14260	COG0456	acetyltransferase
H7R46_RS14275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R46_RS14280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7R46_RS14290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7R46_RS14305	COG1981	membrane
H7R46_RS14315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7R46_RS14315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R46_RS14335	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS14340	COG4638	Rieske (2fe-2S)
H7R46_RS14345	COG0657	acetylesterase activity
H7R46_RS14355	COG0473	3-isopropylmalate dehydrogenase activity
H7R46_RS14360	COG0583	DNA-binding transcription factor activity
H7R46_RS14380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R46_RS14415	COG0358	DNA primase activity
H7R46_RS14430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7R46_RS14460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R46_RS14490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R46_RS14500	COG0351	phosphomethylpyrimidine kinase
H7R46_RS14500	COG0352	thiamine-phosphate diphosphorylase activity
H7R46_RS14500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7R46_RS14505	COG1652	LysM domain
H7R46_RS14530	COG1399	metal-binding, possibly nucleic acid-binding protein
H7R46_RS14535	COG3101	peptidyl-lysine hydroxylation
H7R46_RS14540	COG0009	L-threonylcarbamoyladenylate synthase
H7R46_RS14545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7R46_RS14550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7R46_RS14565	COG4106	trans-aconitate 2-methyltransferase activity
H7R46_RS14580	COG0596	Alpha beta hydrolase
H7R46_RS14580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7R46_RS14580	COG2226	methyltransferase
H7R46_RS14590	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H7R46_RS14595	COG2223	nitrite transmembrane transporter activity
H7R46_RS14615	COG1196	nuclear chromosome segregation
H7R46_RS14625	COG0730	response to heat
H7R46_RS14640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7R46_RS14650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R46_RS14705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R46_RS14710	COG0489	protein tyrosine kinase activity
H7R46_RS14720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R46_RS14720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R46_RS14755	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H7R46_RS14760	COG2081	HI0933 family
H7R46_RS14770	COG0668	transmembrane transport
H7R46_RS14790	COG0583	DNA-binding transcription factor activity
H7R46_RS14810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R46_RS14815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7R46_RS14845	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H7R46_RS14870	COG2199	diguanylate cyclase activity
H7R46_RS14885	COG0745	RESPONSE REGULATOR receiver
H7R46_RS14900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R46_RS14945	COG0110	maltose O-acetyltransferase activity
H7R46_RS14950	COG0438	transferase activity, transferring glycosyl groups
H7R46_RS14960	COG3328	transposase activity
H7R46_RS15065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7R46_RS15080	COG0583	DNA-binding transcription factor activity
H7R46_RS15110	COG0583	DNA-binding transcription factor activity
H7R46_RS15125	COG0583	DNA-binding transcription factor activity
H7R46_RS15130	COG1053	succinate dehydrogenase
H7R46_RS15145	COG1309	transcriptional regulator
H7R46_RS15155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7R46_RS15160	COG2814	Major facilitator Superfamily
H7R46_RS15165	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS15170	COG0583	DNA-binding transcription factor activity
H7R46_RS15175	COG1063	alcohol dehydrogenase
H7R46_RS15205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7R46_RS15210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7R46_RS15215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7R46_RS15235	COG2132	Multicopper oxidase
H7R46_RS15245	COG0561	phosphatase activity
H7R46_RS15250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7R46_RS15260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7R46_RS15275	COG1214	PFAM Peptidase M22, glycoprotease
H7R46_RS15335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7R46_RS15340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7R46_RS15345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7R46_RS15405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R46_RS15415	COG1846	Transcriptional regulator
H7R46_RS15420	COG1764	response to oxidative stress
H7R46_RS15460	COG0037	tRNA processing
H7R46_RS15470	COG0248	Ppx GppA phosphatase
H7R46_RS15500	COG0072	phenylalanine-tRNA ligase activity
H7R46_RS15520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7R46_RS15535	COG1238	metal cluster binding
H7R46_RS15540	COG0625	glutathione transferase activity
H7R46_RS15555	COG0318	PFAM AMP-dependent synthetase and ligase
H7R46_RS15560	COG3028	Belongs to the UPF0307 family
H7R46_RS15565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R46_RS15585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7R46_RS15590	COG0617	tRNA 3'-terminal CCA addition
H7R46_RS15595	COG1555	photosystem II stabilization
H7R46_RS15600	COG3956	TIGRFAM MazG family protein
H7R46_RS15605	COG4221	oxidoreductase activity
H7R46_RS15610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R46_RS15625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R46_RS15630	COG0784	Response regulator, receiver
H7R46_RS15630	COG2205	protein histidine kinase activity
H7R46_RS15630	COG5002	protein histidine kinase activity
H7R46_RS15635	COG1024	Enoyl-CoA hydratase
H7R46_RS15640	COG2084	Dehydrogenase
H7R46_RS15645	COG3622	Belongs to the hyi family
H7R46_RS15680	COG0697	spore germination
H7R46_RS15690	COG2814	Major facilitator Superfamily
H7R46_RS15715	COG2072	flavoprotein involved in K transport
H7R46_RS15720	COG0492	ferredoxin-NADP+ reductase activity
H7R46_RS15725	COG0431	NADPH-dependent FMN reductase
H7R46_RS15730	COG0798	PFAM Bile acid sodium symporter
H7R46_RS15740	COG0640	Transcriptional regulator
H7R46_RS15775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R46_RS15800	COG2132	Multicopper oxidase
H7R46_RS15815	COG2205	protein histidine kinase activity
H7R46_RS15905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R46_RS15915	COG0583	DNA-binding transcription factor activity
H7R46_RS15925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7R46_RS15935	COG0084	hydrolase, TatD family'
H7R46_RS15950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7R46_RS15970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7R46_RS15975	COG0440	acetolactate synthase activity
H7R46_RS15980	COG0028	Belongs to the TPP enzyme family
H7R46_RS16000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R46_RS16005	COG1136	(ABC) transporter
H7R46_RS16005	COG0577	efflux transmembrane transporter activity
H7R46_RS16025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7R46_RS16030	COG1162	GTPase activity
H7R46_RS16040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7R46_RS16060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R46_RS16080	COG1426	Protein conserved in bacteria
H7R46_RS16115	COG0793	Belongs to the peptidase S41A family
H7R46_RS16130	COG2267	carboxylic ester hydrolase activity
H7R46_RS16140	COG1012	belongs to the aldehyde dehydrogenase family
H7R46_RS16145	COG3265	gluconokinase activity
H7R46_RS16155	COG0800	Aldolase
H7R46_RS16170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R46_RS16175	COG0280	phosphate acetyltransferase
H7R46_RS16175	COG0857	belongs to the CobB CobQ family
H7R46_RS16180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H7R46_RS16180	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H7R46_RS16200	COG0740	serine-type endopeptidase activity
H7R46_RS16210	COG4774	siderophore transport
H7R46_RS16220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R46_RS16230	COG2813	Specifically methylates the guanine in position
H7R46_RS16230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7R46_RS16330	COG0788	formyltetrahydrofolate deformylase activity
H7R46_RS16355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7R46_RS16355	COG4651	solute:proton antiporter activity
H7R46_RS16375	COG0724	RNA recognition motif
H7R46_RS16380	COG0210	DNA helicase
H7R46_RS16405	COG1733	regulation of RNA biosynthetic process
H7R46_RS16415	COG2900	Belongs to the SlyX family
H7R46_RS16420	COG0488	(ABC) transporter
H7R46_RS16430	COG1560	Kdo2-lipid A biosynthetic process
H7R46_RS16440	COG1301	dicarboxylic acid transport
H7R46_RS16495	COG0473	3-isopropylmalate dehydrogenase activity
H7R46_RS16520	COG0583	DNA-binding transcription factor activity
H7R46_RS16560	COG0583	DNA-binding transcription factor activity
H7R46_RS16570	COG0625	glutathione transferase activity
H7R46_RS16575	COG2378	regulation of single-species biofilm formation
H7R46_RS16580	COG0546	phosphoglycolate phosphatase activity
H7R46_RS16590	COG1530	ribonuclease E activity
H7R46_RS16595	COG0318	PFAM AMP-dependent synthetase and ligase
H7R46_RS16610	COG0583	DNA-binding transcription factor activity
H7R46_RS16615	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS16620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R46_RS16630	COG0534	Mate efflux family protein
H7R46_RS16645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7R46_RS16670	COG0493	'glutamate synthase
H7R46_RS16680	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7R46_RS16685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R46_RS16700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7R46_RS16710	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H7R46_RS16710	COG0644	oxidoreductase
H7R46_RS16725	COG4535	Mg2 and Co2 transporter CorC
H7R46_RS16735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R46_RS16755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7R46_RS16765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7R46_RS16775	COG0484	heat shock protein binding
H7R46_RS16780	COG0789	Transcriptional regulator
H7R46_RS16785	COG0598	Magnesium transport protein CorA
H7R46_RS16790	COG1185	polyribonucleotide nucleotidyltransferase activity
H7R46_RS16800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7R46_RS16805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R46_RS16810	COG1074	ATP-dependent DNA helicase activity
H7R46_RS16815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7R46_RS16835	COG2226	methyltransferase
H7R46_RS16850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R46_RS16860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7R46_RS16875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7R46_RS16875	COG2111	Na H antiporter
H7R46_RS16880	COG1006	Multisubunit Na H antiporter MnhC subunit
H7R46_RS16885	COG0651	ATP synthesis coupled electron transport
H7R46_RS16890	COG1863	multisubunit Na H antiporter MnhE subunit
H7R46_RS16895	COG2212	antiporter activity
H7R46_RS16900	COG1320	monovalent cation:proton antiporter activity
H7R46_RS16905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7R46_RS16915	COG0195	Participates in both transcription termination and antitermination
H7R46_RS16965	COG0237	dephospho-CoA kinase activity
H7R46_RS16975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R46_RS16990	COG0497	DNA recombination
H7R46_RS17000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R46_RS17035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7R46_RS17035	COG2169	Transcriptional regulator
H7R46_RS17040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7R46_RS17110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7R46_RS17125	COG0326	Molecular chaperone. Has ATPase activity
H7R46_RS17140	COG2056	Na+-H+ antiporter family
H7R46_RS17210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R46_RS17240	COG0546	phosphoglycolate phosphatase activity
H7R46_RS17245	COG1716	ATPase activity
H7R46_RS17290	COG0181	hydroxymethylbilane synthase activity
H7R46_RS17300	COG3275	phosphorelay sensor kinase activity
H7R46_RS17320	COG1538	Outer membrane efflux protein
H7R46_RS17330	COG0697	spore germination
H7R46_RS17355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7R46_RS17360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7R46_RS17365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R46_RS17370	COG0772	Belongs to the SEDS family
H7R46_RS17395	COG4974	Belongs to the 'phage' integrase family
H7R46_RS17400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R46_RS17410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R46_RS17420	COG2197	response regulator
H7R46_RS17435	COG0793	Belongs to the peptidase S41A family
H7R46_RS17440	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7R46_RS17445	COG0795	lipopolysaccharide-transporting ATPase activity
H7R46_RS17485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R46_RS17485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R46_RS17495	COG0004	ammonium transporteR
H7R46_RS17500	COG0347	Belongs to the P(II) protein family
H7R46_RS17510	COG0606	chelatase, subunit chli
H7R46_RS17515	COG0431	NADPH-dependent FMN reductase
H7R46_RS17520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R46_RS17525	COG0235	Class ii aldolase
H7R46_RS17530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R46_RS17550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7R46_RS17565	COG0318	PFAM AMP-dependent synthetase and ligase
H7R46_RS17575	COG0477	Major facilitator Superfamily
H7R46_RS17580	COG2860	membrane
H7R46_RS17590	COG1253	flavin adenine dinucleotide binding
H7R46_RS17600	COG2814	Major facilitator Superfamily
H7R46_RS17610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R46_RS17650	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7R46_RS17665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R46_RS17695	COG1309	transcriptional regulator
H7R46_RS17730	COG0758	DNA mediated transformation
H7R46_RS17740	COG0697	spore germination
H7R46_RS17745	COG1309	transcriptional regulator
H7R46_RS17760	COG0386	Belongs to the glutathione peroxidase family
H7R46_RS17775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7R46_RS17785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7R46_RS17825	COG1121	(ABC) transporter
H7R46_RS17830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7R46_RS17835	COG1280	lysine exporter protein (LysE YggA)
H7R46_RS17840	COG2837	iron assimilation
H7R46_RS17845	COG0281	malic enzyme
H7R46_RS17885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R46_RS17885	COG0519	Catalyzes the synthesis of GMP from XMP
H7R46_RS17890	COG4399	Belongs to the UPF0754 family
H7R46_RS17895	COG2259	Doxx family
H7R46_RS17900	COG0586	Pfam SNARE associated Golgi protein
H7R46_RS17915	COG1192	Involved in chromosome partitioning
H7R46_RS17925	COG0271	Belongs to the BolA IbaG family
H7R46_RS17965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R46_RS17965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R46_RS17965	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H7R46_RS17965	COG3321	synthase
H7R46_RS17970	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS17975	COG0318	PFAM AMP-dependent synthetase and ligase
H7R46_RS17980	COG2197	response regulator
H7R46_RS17990	COG3916	Acyl-homoserine-lactone synthase
H7R46_RS17995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R46_RS18005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R46_RS18010	COG1113	amino acid transport
H7R46_RS18015	COG0697	spore germination
H7R46_RS18020	COG0477	Major facilitator Superfamily
H7R46_RS18025	COG1024	Enoyl-CoA hydratase
H7R46_RS18030	COG1024	Enoyl-CoA hydratase
H7R46_RS18035	COG1960	acyl-CoA dehydrogenase activity
H7R46_RS18040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R46_RS18060	COG1113	amino acid transport
H7R46_RS18065	COG1113	amino acid transport
H7R46_RS18070	COG0251	oxidation-reduction process
H7R46_RS18110	COG0564	pseudouridine synthase activity
H7R46_RS18170	COG2357	RelA SpoT domain protein
H7R46_RS18180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7R46_RS18195	COG1802	Transcriptional regulator
H7R46_RS18205	COG1448	Aminotransferase
H7R46_RS18210	COG0277	FAD linked oxidase domain protein
H7R46_RS18220	COG2186	Transcriptional regulator
H7R46_RS18230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R46_RS18245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7R46_RS18250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7R46_RS18285	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7R46_RS18320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H7R46_RS18350	COG0728	peptidoglycan biosynthetic process
H7R46_RS18355	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7R46_RS18410	COG0546	phosphoglycolate phosphatase activity
H7R46_RS18415	COG1028	Short-chain dehydrogenase reductase Sdr
H7R46_RS18430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7R46_RS18430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R46_RS18435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7R46_RS18440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7R46_RS18445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R46_RS18450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7R46_RS18455	COG1116	anion transmembrane transporter activity
H7R46_RS18460	COG1309	transcriptional regulator
H7R46_RS18465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R46_RS18475	COG0196	riboflavin kinase activity
H7R46_RS18480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7R46_RS18490	COG1047	Peptidyl-prolyl cis-trans
H7R46_RS18530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R46_RS18535	COG0657	acetylesterase activity
H7R46_RS18585	COG2951	lytic endotransglycosylase activity
H7R46_RS18590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7R46_RS18605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R46_RS18615	COG0671	phosphoesterase, PA-phosphatase related
H7R46_RS18620	COG0861	Integral membrane protein TerC family
H7R46_RS18630	COG0754	glutathionylspermidine amidase activity
H7R46_RS18640	COG0402	S-adenosylhomocysteine deaminase activity
H7R46_RS18655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R46_RS18660	COG1230	cation diffusion facilitator family transporter
H7R46_RS18675	COG0706	membrane insertase activity
H7R46_RS18705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R46_RS18800	COG1373	ATPase (AAA superfamily
H7R46_RS18840	COG1309	transcriptional regulator
H7R46_RS18865	COG0633	Ferredoxin
H7R46_RS18870	COG2207	Transcriptional regulator
H7R46_RS18925	COG0789	Transcriptional regulator
H7R46_RS18945	COG0582	viral genome integration into host DNA
H7R46_RS18960	COG2130	NADP-dependent
H7R46_RS18965	COG1309	transcriptional regulator
H7R46_RS18975	COG1902	pentaerythritol trinitrate reductase activity
H7R46_RS18985	COG1979	alcohol dehydrogenase
H7R46_RS19000	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7R46_RS19030	COG0477	Major facilitator Superfamily
H7R46_RS19035	COG0697	spore germination
H7R46_RS19045	COG0604	alcohol dehydrogenase
H7R46_RS19045	COG3321	synthase
H7R46_RS19050	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7R46_RS19055	COG0583	DNA-binding transcription factor activity
H7R46_RS19060	COG4221	oxidoreductase activity
H7R46_RS19155	COG0589	response to stress
H7R46_RS19160	COG0659	secondary active sulfate transmembrane transporter activity
H7R46_RS19190	COG4683	PFAM Phage derived protein Gp49-like (DUF891)