locus-tag	class	description
F2A31_RS00010	COG0592	DNA-directed DNA polymerase activity
F2A31_RS00020	COG0187	DNA topoisomerase II activity
F2A31_RS00025	COG0586	Pfam SNARE associated Golgi protein
F2A31_RS00030	COG0488	(ABC) transporter
F2A31_RS00055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F2A31_RS00060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F2A31_RS00100	COG3273	potassium ion transport
F2A31_RS00100	COG0471	metal ion transport
F2A31_RS00110	COG1012	belongs to the aldehyde dehydrogenase family
F2A31_RS00115	COG3738	Protein conserved in bacteria
F2A31_RS00125	COG0733	neurotransmitter:sodium symporter activity
F2A31_RS00165	COG2233	PERMEase
F2A31_RS00175	COG1309	transcriptional regulator
F2A31_RS00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F2A31_RS00210	COG2814	Major facilitator Superfamily
F2A31_RS00215	COG0656	L-ascorbic acid biosynthetic process
F2A31_RS00220	COG0583	DNA-binding transcription factor activity
F2A31_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F2A31_RS00235	COG1064	alcohol dehydrogenase
F2A31_RS00240	COG2818	Glycosylase
F2A31_RS00255	COG1194	a g-specific adenine glycosylase
F2A31_RS00265	COG5487	UPF0391 membrane protein
F2A31_RS00270	COG2983	Belongs to the UPF0260 family
F2A31_RS00275	COG2133	pyrroloquinoline quinone binding
F2A31_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F2A31_RS00300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F2A31_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F2A31_RS00315	COG1335	isochorismatase
F2A31_RS00320	COG1522	sequence-specific DNA binding
F2A31_RS00330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F2A31_RS00340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F2A31_RS00345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F2A31_RS00350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F2A31_RS00370	COG0560	Phosphoserine phosphatase
F2A31_RS00370	COG3830	Belongs to the UPF0237 family
F2A31_RS00390	COG0753	catalase activity
F2A31_RS00415	COG0384	phenazine biosynthesis protein PhzF
F2A31_RS00420	COG1278	Cold shock
F2A31_RS00425	COG0583	DNA-binding transcription factor activity
F2A31_RS00455	COG0534	Mate efflux family protein
F2A31_RS00460	COG0436	Aminotransferase
F2A31_RS00465	COG2733	membrane
F2A31_RS00480	COG2918	glutathione biosynthetic process
F2A31_RS00495	COG3150	esterase
F2A31_RS00535	COG1247	-acetyltransferase
F2A31_RS00565	COG0625	glutathione transferase activity
F2A31_RS00570	COG1132	(ABC) transporter
F2A31_RS00590	COG1393	Belongs to the ArsC family
F2A31_RS00595	COG0708	Exodeoxyribonuclease III
F2A31_RS00605	COG1181	Belongs to the D-alanine--D-alanine ligase family
F2A31_RS00615	COG0300	oxidoreductase activity
F2A31_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS00645	COG0386	Belongs to the glutathione peroxidase family
F2A31_RS00650	COG0189	ligase activity
F2A31_RS00670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F2A31_RS00680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F2A31_RS00705	COG0508	dehydrogenase complex catalyzes the overall conversion of
F2A31_RS00720	COG2119	membrane
F2A31_RS00725	COG4774	siderophore transport
F2A31_RS00730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F2A31_RS00730	COG0426	domain, Protein
F2A31_RS00755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F2A31_RS00780	COG1902	pentaerythritol trinitrate reductase activity
F2A31_RS00785	COG1519	Transferase
F2A31_RS00795	COG0668	transmembrane transport
F2A31_RS00800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F2A31_RS00855	COG0300	oxidoreductase activity
F2A31_RS00865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F2A31_RS00865	COG0351	phosphomethylpyrimidine kinase
F2A31_RS00865	COG0352	thiamine-phosphate diphosphorylase activity
F2A31_RS00875	COG2814	Major facilitator Superfamily
F2A31_RS00900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F2A31_RS00905	COG1012	belongs to the aldehyde dehydrogenase family
F2A31_RS00915	COG1335	isochorismatase
F2A31_RS00925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F2A31_RS00940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F2A31_RS01005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F2A31_RS01030	COG0659	secondary active sulfate transmembrane transporter activity
F2A31_RS01050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F2A31_RS01085	COG0427	acetyl-CoA hydrolase
F2A31_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS01140	COG0583	DNA-binding transcription factor activity
F2A31_RS01160	COG4221	oxidoreductase activity
F2A31_RS01165	COG2873	o-acetylhomoserine
F2A31_RS01170	COG0488	(ABC) transporter
F2A31_RS01245	COG0833	amino acid
F2A31_RS01285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F2A31_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F2A31_RS01300	COG2226	methyltransferase
F2A31_RS01350	COG0067	glutamate synthase
F2A31_RS01350	COG0070	glutamate synthase
F2A31_RS01350	COG0069	glutamate synthase activity
F2A31_RS01355	COG0493	'glutamate synthase
F2A31_RS01365	COG1704	LemA family
F2A31_RS01370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F2A31_RS01395	COG3307	-O-antigen
F2A31_RS01415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F2A31_RS01425	COG0194	GDP metabolic process
F2A31_RS01435	COG4969	Belongs to the N-Me-Phe pilin family
F2A31_RS01500	COG0228	four-way junction DNA binding
F2A31_RS01505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F2A31_RS01515	COG0335	large ribosomal subunit rRNA binding
F2A31_RS01525	COG5380	lipid catabolic process
F2A31_RS01530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F2A31_RS01550	COG5006	permease, DMT superfamily
F2A31_RS01555	COG1196	nuclear chromosome segregation
F2A31_RS01555	COG0741	lytic transglycosylase activity
F2A31_RS01555	COG0739	heme binding
F2A31_RS01565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F2A31_RS01570	COG0277	FAD linked oxidase domain protein
F2A31_RS01595	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F2A31_RS01600	COG2249	NAD(P)H dehydrogenase (quinone) activity
F2A31_RS01615	COG1289	transmembrane transporter activity
F2A31_RS01620	COG0628	permease
F2A31_RS01625	COG1192	Involved in chromosome partitioning
F2A31_RS01635	COG2226	methyltransferase
F2A31_RS01670	COG1404	Belongs to the peptidase S8 family
F2A31_RS01680	COG2072	flavoprotein involved in K transport
F2A31_RS01725	COG0471	metal ion transport
F2A31_RS01730	COG0517	IMP dehydrogenase activity
F2A31_RS01730	COG0617	tRNA 3'-terminal CCA addition
F2A31_RS01730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F2A31_RS01735	COG1983	PspC domain protein
F2A31_RS01745	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS01770	COG0408	coproporphyrinogen oxidase activity
F2A31_RS01810	COG1127	ABC transporter
F2A31_RS01815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F2A31_RS01820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F2A31_RS01825	COG2854	intermembrane phospholipid transfer
F2A31_RS01840	COG0598	Magnesium transport protein CorA
F2A31_RS01855	COG1040	competence protein
F2A31_RS01860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F2A31_RS01880	COG1946	Acyl-CoA thioesterase
F2A31_RS01885	COG1301	dicarboxylic acid transport
F2A31_RS01905	COG1959	2 iron, 2 sulfur cluster binding
F2A31_RS01915	COG0433	COG0433 Predicted ATPase
F2A31_RS01935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F2A31_RS01955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F2A31_RS02085	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS02090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F2A31_RS02115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F2A31_RS02135	COG0339	signal peptide processing
F2A31_RS02140	COG0557	exoribonuclease II activity
F2A31_RS02215	COG0179	Fumarylacetoacetate (FAA) hydrolase
F2A31_RS02225	COG2207	Transcriptional regulator
F2A31_RS02235	COG1295	ribonuclease BN
F2A31_RS02265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F2A31_RS02290	COG2813	Specifically methylates the guanine in position
F2A31_RS02290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F2A31_RS02300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F2A31_RS02310	COG4771	TonB-dependent receptor
F2A31_RS02320	COG0740	serine-type endopeptidase activity
F2A31_RS02340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F2A31_RS02340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F2A31_RS02345	COG2207	Transcriptional regulator
F2A31_RS02345	COG1917	Cupin 2, conserved barrel domain protein
F2A31_RS02350	COG0697	spore germination
F2A31_RS02365	COG0280	phosphate acetyltransferase
F2A31_RS02365	COG0857	belongs to the CobB CobQ family
F2A31_RS02370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F2A31_RS02380	COG2267	carboxylic ester hydrolase activity
F2A31_RS02395	COG0793	Belongs to the peptidase S41A family
F2A31_RS02415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F2A31_RS02425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F2A31_RS02430	COG1408	metallophosphoesterase
F2A31_RS02440	COG2199	diguanylate cyclase activity
F2A31_RS02480	COG0628	permease
F2A31_RS02485	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS02505	COG1309	transcriptional regulator
F2A31_RS02525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F2A31_RS02530	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS02585	COG2969	positive regulation of protein catabolic process
F2A31_RS02590	COG0625	glutathione transferase activity
F2A31_RS02600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F2A31_RS02605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F2A31_RS02615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F2A31_RS02620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F2A31_RS02625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F2A31_RS02640	COG2975	iron-sulfur cluster assembly
F2A31_RS02660	COG1426	Protein conserved in bacteria
F2A31_RS02700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F2A31_RS02705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F2A31_RS02730	COG2986	histidine ammonia-lyase
F2A31_RS02770	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS02775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F2A31_RS02790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F2A31_RS02800	COG1862	Preprotein translocase
F2A31_RS02830	COG5002	protein histidine kinase activity
F2A31_RS02835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F2A31_RS02845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F2A31_RS02880	COG3306	glycosyltransferase involved in LPS biosynthesis
F2A31_RS02905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F2A31_RS02945	COG0625	glutathione transferase activity
F2A31_RS02950	COG0583	DNA-binding transcription factor activity
F2A31_RS02955	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS02960	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS02970	COG2205	protein histidine kinase activity
F2A31_RS02975	COG0745	RESPONSE REGULATOR receiver
F2A31_RS02985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F2A31_RS03005	COG2096	Adenosyltransferase
F2A31_RS03010	COG4206	TonB-dependent receptor
F2A31_RS03085	COG0285	dihydrofolate synthase activity
F2A31_RS03100	COG0450	alkyl hydroperoxide reductase
F2A31_RS03120	COG0477	Major facilitator Superfamily
F2A31_RS03125	COG1272	protein, Hemolysin III
F2A31_RS03160	COG0183	Belongs to the thiolase family
F2A31_RS03170	COG2207	Transcriptional regulator
F2A31_RS03175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F2A31_RS03210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F2A31_RS03225	COG0183	Belongs to the thiolase family
F2A31_RS03235	COG2885	chlorophyll binding
F2A31_RS03235	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F2A31_RS03240	COG2885	chlorophyll binding
F2A31_RS03240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F2A31_RS03245	COG1690	Belongs to the RtcB family
F2A31_RS03250	COG0833	amino acid
F2A31_RS03260	COG2233	PERMEase
F2A31_RS03265	COG1217	gtp-binding protein TYPA
F2A31_RS03275	COG1970	mechanosensitive ion channel activity
F2A31_RS03295	COG4772	TonB-dependent receptor
F2A31_RS03315	COG0354	folic acid binding
F2A31_RS03325	COG2824	Alkylphosphonate utilization operon protein PhnA
F2A31_RS03330	COG3422	double-strand break repair
F2A31_RS03360	COG0840	transmembrane signaling receptor activity
F2A31_RS03365	COG2198	Histidine kinase
F2A31_RS03365	COG0643	Histidine kinase
F2A31_RS03365	COG0643	Histidine kinase
F2A31_RS03365	COG2198	Histidine kinase
F2A31_RS03380	COG5510	response to toxic substance
F2A31_RS03390	COG2832	Protein of unknown function (DUF454)
F2A31_RS03395	COG1376	ErfK ybiS ycfS ynhG family protein
F2A31_RS03450	COG1289	transmembrane transporter activity
F2A31_RS03455	COG2814	Major facilitator Superfamily
F2A31_RS03470	COG0786	glutamate:sodium symporter activity
F2A31_RS03475	COG1115	amino acid carrier protein
F2A31_RS03480	COG1752	Esterase of the alpha-beta hydrolase superfamily
F2A31_RS03485	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
F2A31_RS03530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F2A31_RS03540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F2A31_RS03545	COG1077	Cell shape determining protein MreB Mrl
F2A31_RS03550	COG1792	Involved in formation and maintenance of cell shape
F2A31_RS03560	COG0424	maF-like protein
F2A31_RS03575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F2A31_RS03585	COG0560	Phosphoserine phosphatase
F2A31_RS03600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F2A31_RS03605	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F2A31_RS03610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F2A31_RS03615	COG2205	protein histidine kinase activity
F2A31_RS03620	COG0745	RESPONSE REGULATOR receiver
F2A31_RS03630	COG0671	phosphoesterase, PA-phosphatase related
F2A31_RS03640	COG4771	TonB-dependent receptor
F2A31_RS03655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F2A31_RS03670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F2A31_RS03695	COG1113	amino acid transport
F2A31_RS03700	COG2828	Protein conserved in bacteria
F2A31_RS03705	COG0142	geranyltranstransferase activity
F2A31_RS03720	COG1752	Esterase of the alpha-beta hydrolase superfamily
F2A31_RS03740	COG2194	sulfuric ester hydrolase activity
F2A31_RS03745	COG0745	RESPONSE REGULATOR receiver
F2A31_RS03750	COG0642	Histidine kinase
F2A31_RS03760	COG1126	abc transporter atp-binding protein
F2A31_RS03765	COG0765	amino acid transport
F2A31_RS03770	COG0765	amino acid transport
F2A31_RS03780	COG0004	ammonium transporteR
F2A31_RS03795	COG2852	Protein conserved in bacteria
F2A31_RS03810	COG0525	valine-tRNA ligase activity
F2A31_RS03825	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS03835	COG0393	Putative heavy-metal-binding
F2A31_RS03840	COG0393	Putative heavy-metal-binding
F2A31_RS03845	COG1538	Outer membrane efflux protein
F2A31_RS03855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F2A31_RS03860	COG0671	phosphoesterase, PA-phosphatase related
F2A31_RS03890	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F2A31_RS03905	COG1648	precorrin-2 dehydrogenase activity
F2A31_RS03905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F2A31_RS03910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F2A31_RS03920	COG1733	regulation of RNA biosynthetic process
F2A31_RS03935	COG0531	amino acid
F2A31_RS03950	COG0321	lipoyl(octanoyl) transferase activity
F2A31_RS03975	COG1280	lysine exporter protein (LysE YggA)
F2A31_RS03985	COG0500	methyltransferase
F2A31_RS04005	COG2009	succinate dehydrogenase
F2A31_RS04010	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F2A31_RS04015	COG1053	succinate dehydrogenase
F2A31_RS04020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F2A31_RS04035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F2A31_RS04050	COG2268	Band 7 protein
F2A31_RS04055	COG1585	Membrane protein implicated in regulation of membrane protease activity
F2A31_RS04065	COG2354	Protein conserved in bacteria
F2A31_RS04070	COG2321	neutral zinc metallopeptidase
F2A31_RS04105	COG0438	transferase activity, transferring glycosyl groups
F2A31_RS04145	COG0110	maltose O-acetyltransferase activity
F2A31_RS04160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F2A31_RS04165	COG0505	Belongs to the CarA family
F2A31_RS04190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F2A31_RS04205	COG2304	oxidoreductase activity
F2A31_RS04230	COG0584	glycerophosphoryl diester phosphodiesterase
F2A31_RS04235	COG2194	sulfuric ester hydrolase activity
F2A31_RS04240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F2A31_RS04245	COG2239	Acts as a magnesium transporter
F2A31_RS04255	COG0501	Belongs to the peptidase M48B family
F2A31_RS04260	COG0741	lytic transglycosylase activity
F2A31_RS04265	COG0037	tRNA processing
F2A31_RS04275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F2A31_RS04280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F2A31_RS04290	COG1301	dicarboxylic acid transport
F2A31_RS04295	COG0583	DNA-binding transcription factor activity
F2A31_RS04410	COG0725	ABC transporter, periplasmic molybdate-binding protein
F2A31_RS04415	COG4149	molybdate abc transporter
F2A31_RS04430	COG1230	cation diffusion facilitator family transporter
F2A31_RS04445	COG4521	taurine ABC transporter
F2A31_RS04450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F2A31_RS04455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F2A31_RS04460	COG2175	clavaminate synthase activity
F2A31_RS04490	COG0589	response to stress
F2A31_RS04505	COG0242	peptide deformylase activity
F2A31_RS04510	COG2852	Protein conserved in bacteria
F2A31_RS04535	COG0306	phosphate transporter
F2A31_RS04550	COG1115	amino acid carrier protein
F2A31_RS04560	COG0019	diaminopimelate decarboxylase activity
F2A31_RS04565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F2A31_RS04575	COG1280	lysine exporter protein (LysE YggA)
F2A31_RS04580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F2A31_RS04600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F2A31_RS04630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F2A31_RS04650	COG1671	Belongs to the UPF0178 family
F2A31_RS04665	COG4591	ABC-type transport system involved in lipoprotein release permease component
F2A31_RS04670	COG1136	(ABC) transporter
F2A31_RS04675	COG2333	competence protein COMEC
F2A31_RS04675	COG0658	competence protein
F2A31_RS04685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F2A31_RS04685	COG0616	signal peptide processing
F2A31_RS04695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F2A31_RS04705	COG0628	permease
F2A31_RS04745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F2A31_RS04765	COG0823	Involved in the tonB-independent uptake of proteins
F2A31_RS04785	COG0824	Thioesterase
F2A31_RS04790	COG1473	amidohydrolase
F2A31_RS04795	COG2255	four-way junction helicase activity
F2A31_RS04810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F2A31_RS04810	COG0047	phosphoribosylformylglycinamidine synthase activity
F2A31_RS04825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F2A31_RS04825	COG3323	Protein of unknown function (DUF1653)
F2A31_RS04830	COG0778	Nitroreductase
F2A31_RS04835	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F2A31_RS04835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F2A31_RS04835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F2A31_RS04845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F2A31_RS04845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F2A31_RS04850	COG1024	Enoyl-CoA hydratase
F2A31_RS04855	COG1056	cytidyltransferase-related domain
F2A31_RS04855	COG1051	belongs to the nudix hydrolase family
F2A31_RS04860	COG0583	DNA-binding transcription factor activity
F2A31_RS04865	COG1942	4-Oxalocrotonate Tautomerase
F2A31_RS04885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F2A31_RS04900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F2A31_RS04905	COG0602	queuosine metabolic process
F2A31_RS04920	COG0583	DNA-binding transcription factor activity
F2A31_RS04925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F2A31_RS04930	COG4208	sulfate ABC transporter
F2A31_RS04935	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F2A31_RS04945	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F2A31_RS04950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F2A31_RS04955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F2A31_RS04970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F2A31_RS04980	COG0481	GTPase activity
F2A31_RS04995	COG0571	ribonuclease III activity
F2A31_RS05000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F2A31_RS05015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F2A31_RS05045	COG0436	Aminotransferase
F2A31_RS05070	COG0556	nucleotide-excision repair
F2A31_RS05075	COG3040	lipid binding
F2A31_RS05115	COG1840	ABC-type Fe3 transport system, periplasmic component
F2A31_RS05120	COG3842	ATPase activity
F2A31_RS05140	COG0583	DNA-binding transcription factor activity
F2A31_RS05145	COG0596	Alpha beta hydrolase
F2A31_RS05150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F2A31_RS05155	COG1773	rubredoxin
F2A31_RS05165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F2A31_RS05175	COG0175	sulfate reduction
F2A31_RS05190	COG0222	ribosome binding
F2A31_RS05195	COG1253	flavin adenine dinucleotide binding
F2A31_RS05210	COG3015	lipoprotein NlpE involved in copper resistance
F2A31_RS05225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F2A31_RS05225	COG0517	IMP dehydrogenase activity
F2A31_RS05230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F2A31_RS05240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F2A31_RS05245	COG1137	ATPase activity
F2A31_RS05250	COG1538	Outer membrane efflux protein
F2A31_RS05280	COG4122	O-methyltransferase activity
F2A31_RS05290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F2A31_RS05305	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F2A31_RS05320	COG0583	DNA-binding transcription factor activity
F2A31_RS05350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F2A31_RS05390	COG4783	chaperone-mediated protein folding
F2A31_RS05405	COG1610	YqeY-like protein
F2A31_RS05470	COG2815	serine threonine protein kinase
F2A31_RS05470	COG0515	serine threonine protein kinase
F2A31_RS05510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F2A31_RS05555	COG1215	transferase activity, transferring glycosyl groups
F2A31_RS05565	COG1649	PFAM Uncharacterised BCR, COG1649
F2A31_RS05565	COG0726	polysaccharide deacetylase
F2A31_RS05570	COG1414	Transcriptional regulator
F2A31_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS05600	COG0446	pyridine nucleotide-disulphide oxidoreductase
F2A31_RS05605	COG2271	Major facilitator Superfamily
F2A31_RS05620	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS05635	COG0028	Belongs to the TPP enzyme family
F2A31_RS05655	COG0482	sulfurtransferase activity
F2A31_RS05670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F2A31_RS05675	COG1686	Belongs to the peptidase S11 family
F2A31_RS05695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F2A31_RS05705	COG0583	DNA-binding transcription factor activity
F2A31_RS05710	COG1067	ATP-dependent peptidase activity
F2A31_RS05730	COG0254	rRNA binding
F2A31_RS05750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F2A31_RS05755	COG1966	Carbon starvation protein
F2A31_RS05760	COG2879	small protein
F2A31_RS05765	COG0714	Associated with various cellular activities
F2A31_RS05835	COG2856	Zn peptidase
F2A31_RS05865	COG1741	Belongs to the pirin family
F2A31_RS05880	COG0446	pyridine nucleotide-disulphide oxidoreductase
F2A31_RS05880	COG1902	pentaerythritol trinitrate reductase activity
F2A31_RS05900	COG4689	acetoacetate decarboxylase
F2A31_RS05910	COG1902	pentaerythritol trinitrate reductase activity
F2A31_RS05935	COG0583	DNA-binding transcription factor activity
F2A31_RS05940	COG1902	pentaerythritol trinitrate reductase activity
F2A31_RS06000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F2A31_RS06005	COG4451	ribulose bisphosphate carboxylase, small
F2A31_RS06005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F2A31_RS06010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F2A31_RS06015	COG1469	GTP cyclohydrolase I activity
F2A31_RS06030	COG0523	cobalamin synthesis protein
F2A31_RS06035	COG1414	Transcriptional regulator
F2A31_RS06040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F2A31_RS06045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F2A31_RS06050	COG0183	Belongs to the thiolase family
F2A31_RS06055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F2A31_RS06060	COG0596	Alpha beta hydrolase
F2A31_RS06065	COG2271	Major facilitator Superfamily
F2A31_RS06070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F2A31_RS06075	COG3485	protocatechuate 3,4-dioxygenase
F2A31_RS06080	COG3485	protocatechuate 3,4-dioxygenase
F2A31_RS06085	COG0710	3-dehydroquinate dehydratase activity
F2A31_RS06090	COG3420	alginic acid biosynthetic process
F2A31_RS06095	COG3659	wide pore channel activity
F2A31_RS06100	COG4993	Dehydrogenase
F2A31_RS06110	COG2351	hydroxyisourate hydrolase activity
F2A31_RS06115	COG2233	PERMEase
F2A31_RS06125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F2A31_RS06135	COG4266	Belongs to the allantoicase family
F2A31_RS06150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F2A31_RS06160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F2A31_RS06175	COG0583	DNA-binding transcription factor activity
F2A31_RS06185	COG2188	Transcriptional regulator
F2A31_RS06205	COG0010	Belongs to the arginase family
F2A31_RS06210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F2A31_RS06215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F2A31_RS06225	COG0243	molybdopterin cofactor binding
F2A31_RS06230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F2A31_RS06235	COG2837	iron assimilation
F2A31_RS06245	COG1538	Outer membrane efflux protein
F2A31_RS06250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F2A31_RS06255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F2A31_RS06260	COG0745	RESPONSE REGULATOR receiver
F2A31_RS06265	COG5002	protein histidine kinase activity
F2A31_RS06270	COG3040	lipid binding
F2A31_RS06290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F2A31_RS06300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F2A31_RS06305	COG0642	Histidine kinase
F2A31_RS06325	COG1309	transcriptional regulator
F2A31_RS06345	COG2072	flavoprotein involved in K transport
F2A31_RS06350	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F2A31_RS06355	COG1560	Kdo2-lipid A biosynthetic process
F2A31_RS06360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F2A31_RS06365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F2A31_RS06370	COG4770	biotin carboxylase activity
F2A31_RS06375	COG0501	Belongs to the peptidase M48B family
F2A31_RS06385	COG1765	OsmC-like protein
F2A31_RS06435	COG4133	protoheme IX ABC transporter activity
F2A31_RS06465	COG0308	aminopeptidase N
F2A31_RS06470	COG1760	l-serine dehydratase
F2A31_RS06480	COG1714	RDD family
F2A31_RS06490	COG0475	glutathione-regulated potassium exporter activity
F2A31_RS06490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F2A31_RS06495	COG3135	benzoate transporter
F2A31_RS06505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F2A31_RS06510	COG0583	DNA-binding transcription factor activity
F2A31_RS06525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F2A31_RS06555	COG0316	Belongs to the HesB IscA family
F2A31_RS06560	COG0822	iron-sulfur transferase activity
F2A31_RS06585	COG0776	regulation of translation
F2A31_RS06590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F2A31_RS06605	COG2137	regulation of response to DNA damage stimulus
F2A31_RS06615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F2A31_RS06620	COG1011	Hydrolase
F2A31_RS06625	COG1218	3'(2'),5'-bisphosphate nucleotidase
F2A31_RS06645	COG0268	Binds directly to 16S ribosomal RNA
F2A31_RS06650	COG0702	epimerase
F2A31_RS06655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F2A31_RS06680	COG2030	dehydratase
F2A31_RS06700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F2A31_RS06705	COG0583	DNA-binding transcription factor activity
F2A31_RS06710	COG0424	maF-like protein
F2A31_RS06735	COG0778	Nitroreductase
F2A31_RS06765	COG1286	toxin biosynthetic process
F2A31_RS06810	COG3634	alkyl hydroperoxide reductase activity
F2A31_RS06845	COG0436	Aminotransferase
F2A31_RS06850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F2A31_RS06855	COG0386	Belongs to the glutathione peroxidase family
F2A31_RS06865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F2A31_RS06870	COG1522	sequence-specific DNA binding
F2A31_RS06880	COG0436	Aminotransferase
F2A31_RS06905	COG1253	flavin adenine dinucleotide binding
F2A31_RS06910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F2A31_RS06920	COG0012	GTP binding
F2A31_RS06925	COG2011	ABC-type metal ion transport system permease component
F2A31_RS06930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F2A31_RS06935	COG1464	Belongs to the NlpA lipoprotein family
F2A31_RS06965	COG2195	Cleaves the N-terminal amino acid of tripeptides
F2A31_RS06985	COG1690	Belongs to the RtcB family
F2A31_RS06990	COG1234	tRNA 3'-trailer cleavage
F2A31_RS06995	COG4650	regulator
F2A31_RS07035	COG2363	Small membrane protein
F2A31_RS07055	COG0513	Belongs to the DEAD box helicase family
F2A31_RS07060	COG0191	fructose-bisphosphate aldolase activity
F2A31_RS07065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F2A31_RS07075	COG3178	'Phosphotransferase
F2A31_RS07080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F2A31_RS07090	COG1192	Involved in chromosome partitioning
F2A31_RS07095	COG1475	DNA binding
F2A31_RS07100	COG0811	peptide transport
F2A31_RS07110	COG1132	(ABC) transporter
F2A31_RS07115	COG1663	tetraacyldisaccharide 4'-kinase activity
F2A31_RS07140	COG0084	hydrolase, TatD family'
F2A31_RS07205	COG0776	regulation of translation
F2A31_RS07220	COG2431	L-lysine efflux transmembrane transporter activity
F2A31_RS07235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F2A31_RS07240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F2A31_RS07280	COG0024	Methionine aminopeptidase
F2A31_RS07285	COG0583	DNA-binding transcription factor activity
F2A31_RS07295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F2A31_RS07300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F2A31_RS07305	COG0517	IMP dehydrogenase activity
F2A31_RS07305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F2A31_RS07330	COG0552	protein localization to endoplasmic reticulum
F2A31_RS07355	COG4890	Cyd operon protein YbgT
F2A31_RS07360	COG1294	oxidase, subunit
F2A31_RS07385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F2A31_RS07405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F2A31_RS07410	COG0569	domain protein
F2A31_RS07415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F2A31_RS07435	COG1785	Belongs to the alkaline phosphatase family
F2A31_RS07455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F2A31_RS07460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F2A31_RS07465	COG0542	response to heat
F2A31_RS07475	COG0488	(ABC) transporter
F2A31_RS07480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F2A31_RS07485	COG2267	carboxylic ester hydrolase activity
F2A31_RS07495	COG0446	pyridine nucleotide-disulphide oxidoreductase
F2A31_RS07495	COG1902	pentaerythritol trinitrate reductase activity
F2A31_RS07530	COG0148	phosphopyruvate hydratase activity
F2A31_RS07535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F2A31_RS07595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F2A31_RS07605	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F2A31_RS07620	COG1802	Transcriptional regulator
F2A31_RS07630	COG2207	Transcriptional regulator
F2A31_RS07680	COG1944	ATP diphosphatase activity
F2A31_RS07700	COG1522	sequence-specific DNA binding
F2A31_RS07715	COG0439	Biotin carboxylase
F2A31_RS07720	COG0864	Transcriptional regulator
F2A31_RS07725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F2A31_RS07735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F2A31_RS07760	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS07765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F2A31_RS07775	COG1024	Enoyl-CoA hydratase
F2A31_RS07790	COG0183	Belongs to the thiolase family
F2A31_RS07795	COG1250	3-hydroxyacyl-CoA dehydrogenase
F2A31_RS07800	COG1024	Enoyl-CoA hydratase
F2A31_RS07805	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS07810	COG2814	Major facilitator Superfamily
F2A31_RS07815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F2A31_RS07820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F2A31_RS07830	COG2814	Major facilitator Superfamily
F2A31_RS07840	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS07845	COG0235	Class ii aldolase
F2A31_RS07860	COG0583	DNA-binding transcription factor activity
F2A31_RS07870	COG4770	biotin carboxylase activity
F2A31_RS07875	COG1024	Enoyl-CoA hydratase
F2A31_RS07880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F2A31_RS07885	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS07890	COG1309	transcriptional regulator
F2A31_RS07895	COG0318	PFAM AMP-dependent synthetase and ligase
F2A31_RS07910	COG2814	Major facilitator Superfamily
F2A31_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS07920	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS07930	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS07950	COG0583	DNA-binding transcription factor activity
F2A31_RS07960	COG4774	siderophore transport
F2A31_RS07990	COG2831	hemolysin activation secretion protein
F2A31_RS07995	COG3210	domain, Protein
F2A31_RS08110	COG3706	GGDEF domain
F2A31_RS08130	COG2205	protein histidine kinase activity
F2A31_RS08150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F2A31_RS08170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F2A31_RS08210	COG0537	adenosine 5'-monophosphoramidase activity
F2A31_RS08240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F2A31_RS08260	COG0730	response to heat
F2A31_RS08265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F2A31_RS08275	COG4771	TonB-dependent receptor
F2A31_RS08290	COG0406	alpha-ribazole phosphatase activity
F2A31_RS08295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F2A31_RS08310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F2A31_RS08340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F2A31_RS08350	COG4264	IucA IucC family
F2A31_RS08360	COG2814	Major facilitator Superfamily
F2A31_RS08390	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS08395	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS08410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F2A31_RS08415	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F2A31_RS08420	COG2207	Transcriptional regulator
F2A31_RS08425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F2A31_RS08435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F2A31_RS08460	COG0575	Belongs to the CDS family
F2A31_RS08465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F2A31_RS08470	COG0233	cytoplasmic translational termination
F2A31_RS08475	COG0528	UMP kinase activity
F2A31_RS08485	COG3852	Histidine kinase
F2A31_RS08495	COG1309	transcriptional regulator
F2A31_RS08540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F2A31_RS08560	COG0697	spore germination
F2A31_RS08565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F2A31_RS08575	COG0303	'Molybdopterin
F2A31_RS08580	COG0521	Mo-molybdopterin cofactor biosynthetic process
F2A31_RS08580	COG0315	cyclic pyranopterin monophosphate synthase activity
F2A31_RS08600	COG0243	molybdopterin cofactor binding
F2A31_RS08615	COG0243	molybdopterin cofactor binding
F2A31_RS08620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F2A31_RS08625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F2A31_RS08625	COG2146	nitrite reductase [NAD(P)H] activity
F2A31_RS08630	COG2223	nitrite transmembrane transporter activity
F2A31_RS08640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F2A31_RS08640	COG1116	anion transmembrane transporter activity
F2A31_RS08655	COG0439	Biotin carboxylase
F2A31_RS08680	COG0069	glutamate synthase activity
F2A31_RS08700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F2A31_RS08705	COG1454	alcohol dehydrogenase
F2A31_RS08710	COG0824	Thioesterase
F2A31_RS08720	COG2850	peptidyl-arginine hydroxylation
F2A31_RS08760	COG3122	Protein conserved in bacteria
F2A31_RS08765	COG0668	transmembrane transport
F2A31_RS08775	COG1132	(ABC) transporter
F2A31_RS08795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F2A31_RS08805	COG0506	proline dehydrogenase activity
F2A31_RS08805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F2A31_RS08805	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F2A31_RS08810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F2A31_RS08815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F2A31_RS08825	COG3698	Phosphodiester glycosidase
F2A31_RS08840	COG3153	acetyltransferase
F2A31_RS08845	COG2353	YceI-like domain
F2A31_RS08870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F2A31_RS08875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F2A31_RS08890	COG3042	response to heat
F2A31_RS08895	COG1278	Cold shock
F2A31_RS08900	COG1278	Cold shock
F2A31_RS08920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F2A31_RS08920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F2A31_RS08945	COG3539	Fimbrial protein
F2A31_RS08995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F2A31_RS09015	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS09020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F2A31_RS09045	COG3139	Protein of unknown function (DUF1315)
F2A31_RS09050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F2A31_RS09055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F2A31_RS09065	COG0494	nUDIX hydrolase
F2A31_RS09075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F2A31_RS09080	COG1720	tRNA m6t6A37 methyltransferase activity
F2A31_RS09090	COG1309	transcriptional regulator
F2A31_RS09115	COG0583	DNA-binding transcription factor activity
F2A31_RS09120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F2A31_RS09125	COG0569	domain protein
F2A31_RS09130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F2A31_RS09140	COG2814	Major facilitator Superfamily
F2A31_RS09145	COG4607	ABC-type enterochelin transport system periplasmic component
F2A31_RS09150	COG4604	ABC transporter, ATP-binding protein
F2A31_RS09155	COG4605	iron ion homeostasis
F2A31_RS09160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F2A31_RS09170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F2A31_RS09200	COG0729	surface antigen
F2A31_RS09205	COG0477	Major facilitator Superfamily
F2A31_RS09225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F2A31_RS09235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F2A31_RS09270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F2A31_RS09330	COG1131	(ABC) transporter
F2A31_RS09335	COG0842	Transport permease protein
F2A31_RS09350	COG0772	Belongs to the SEDS family
F2A31_RS09355	COG2951	lytic endotransglycosylase activity
F2A31_RS09375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F2A31_RS09380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F2A31_RS09395	COG1643	Atp-dependent helicase
F2A31_RS09405	COG0450	alkyl hydroperoxide reductase
F2A31_RS09415	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F2A31_RS09435	COG3634	alkyl hydroperoxide reductase activity
F2A31_RS09455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F2A31_RS09470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F2A31_RS09480	COG0531	amino acid
F2A31_RS09485	COG4303	Ethanolamine ammonia lyase large subunit
F2A31_RS09490	COG4302	ethanolamine ammonia-lyase activity
F2A31_RS09495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F2A31_RS09495	COG0519	Catalyzes the synthesis of GMP from XMP
F2A31_RS09500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F2A31_RS09510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F2A31_RS09520	COG2249	NAD(P)H dehydrogenase (quinone) activity
F2A31_RS09530	COG0697	spore germination
F2A31_RS09535	COG1923	regulation of RNA biosynthetic process
F2A31_RS09545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F2A31_RS09550	COG0802	atpase or kinase
F2A31_RS09580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F2A31_RS09585	COG3300	MHYT domain
F2A31_RS09585	COG5001	Diguanylate cyclase
F2A31_RS09605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F2A31_RS09610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F2A31_RS09615	COG1845	cytochrome c oxidase, subunit III
F2A31_RS09620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F2A31_RS09645	COG2249	NAD(P)H dehydrogenase (quinone) activity
F2A31_RS09650	COG1733	regulation of RNA biosynthetic process
F2A31_RS09655	COG0305	Participates in initiation and elongation during chromosome replication
F2A31_RS09660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F2A31_RS09675	COG1305	Transglutaminase-like
F2A31_RS09685	COG2308	Evidence 4 Homologs of previously reported genes of
F2A31_RS09695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F2A31_RS09715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F2A31_RS09725	COG0527	aspartate kinase activity
F2A31_RS09735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F2A31_RS09745	COG3038	cytochrome b561
F2A31_RS09750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F2A31_RS09755	COG2252	PERMEase
F2A31_RS09810	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F2A31_RS09815	COG0138	bifunctional purine biosynthesis protein purh
F2A31_RS09820	COG0151	Belongs to the GarS family
F2A31_RS09825	COG1464	Belongs to the NlpA lipoprotein family
F2A31_RS09830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F2A31_RS09835	COG2011	ABC-type metal ion transport system permease component
F2A31_RS09860	COG0318	PFAM AMP-dependent synthetase and ligase
F2A31_RS09865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F2A31_RS09870	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F2A31_RS09875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F2A31_RS09905	COG0052	Belongs to the universal ribosomal protein uS2 family
F2A31_RS09910	COG0024	Methionine aminopeptidase
F2A31_RS09920	COG2223	nitrite transmembrane transporter activity
F2A31_RS09930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F2A31_RS09935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F2A31_RS09940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F2A31_RS09975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F2A31_RS09980	COG3161	chorismate lyase activity
F2A31_RS09985	COG0174	glutamine synthetase
F2A31_RS10000	COG0512	Glutamine amidotransferase of anthranilate synthase
F2A31_RS10005	COG1823	symporter activity
F2A31_RS10010	COG3217	Mosc domain protein beta barrel domain protein
F2A31_RS10010	COG0633	Ferredoxin
F2A31_RS10030	COG0302	gtp cyclohydrolase
F2A31_RS10050	COG3739	integral membrane protein
F2A31_RS10065	COG2203	Gaf domain
F2A31_RS10065	COG5001	Diguanylate cyclase
F2A31_RS10065	COG4251	negative regulation of phosphorylation
F2A31_RS10065	COG3706	GGDEF domain
F2A31_RS10075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F2A31_RS10090	COG4172	Belongs to the ABC transporter superfamily
F2A31_RS10095	COG4239	(ABC) transporter, permease
F2A31_RS10100	COG4174	ABC transporter (Permease)
F2A31_RS10105	COG4166	transmembrane transport
F2A31_RS10110	COG0741	lytic transglycosylase activity
F2A31_RS10110	COG1388	LysM domain
F2A31_RS10110	COG1388	LysM domain
F2A31_RS10110	COG0741	lytic transglycosylase activity
F2A31_RS10155	COG0583	DNA-binding transcription factor activity
F2A31_RS10160	COG1279	arginine transmembrane transporter activity
F2A31_RS10180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F2A31_RS10185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F2A31_RS10190	COG0006	proline dipeptidase activity
F2A31_RS10220	COG2217	Heavy metal translocating P-type atpase
F2A31_RS10240	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F2A31_RS10250	COG0714	Associated with various cellular activities
F2A31_RS10255	COG3831	ATPase activity
F2A31_RS10270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F2A31_RS10285	COG3384	dioxygenase
F2A31_RS10330	COG2878	Part of a membrane complex involved in electron transport
F2A31_RS10335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F2A31_RS10360	COG0768	penicillin binding
F2A31_RS10365	COG0742	ribosomal rna small subunit methyltransferase
F2A31_RS10390	COG0616	signal peptide processing
F2A31_RS10395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F2A31_RS10405	COG0573	inorganic phosphate transmembrane transporter activity
F2A31_RS10420	COG0076	glutamate decarboxylase activity
F2A31_RS10425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F2A31_RS10435	COG4772	TonB-dependent receptor
F2A31_RS10445	COG1309	transcriptional regulator
F2A31_RS10460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F2A31_RS10500	COG0564	pseudouridine synthase activity
F2A31_RS10515	COG0352	thiamine-phosphate diphosphorylase activity
F2A31_RS10570	COG0612	Peptidase, M16
F2A31_RS10575	COG0384	phenazine biosynthesis protein PhzF
F2A31_RS10595	COG2351	hydroxyisourate hydrolase activity
F2A31_RS10605	COG1686	Belongs to the peptidase S11 family
F2A31_RS10610	COG1252	NADH dehydrogenase
F2A31_RS10620	COG0415	Belongs to the DNA photolyase family
F2A31_RS10635	COG1215	transferase activity, transferring glycosyl groups
F2A31_RS10660	COG1271	oxidase subunit
F2A31_RS10665	COG1294	oxidase, subunit
F2A31_RS10695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F2A31_RS10700	COG4181	ATPase activity
F2A31_RS10710	COG0456	acetyltransferase
F2A31_RS10730	COG4771	TonB-dependent receptor
F2A31_RS10745	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F2A31_RS10770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F2A31_RS10775	COG1597	lipid kinase activity
F2A31_RS10780	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F2A31_RS10790	COG3210	domain, Protein
F2A31_RS10795	COG2831	hemolysin activation secretion protein
F2A31_RS10815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F2A31_RS10825	COG2388	GCN5-related N-acetyl-transferase
F2A31_RS10870	COG4681	YaeQ
F2A31_RS10875	COG0523	cobalamin synthesis protein
F2A31_RS10910	COG1024	Enoyl-CoA hydratase
F2A31_RS10925	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS10950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F2A31_RS10955	COG1414	Transcriptional regulator
F2A31_RS10980	COG1012	belongs to the aldehyde dehydrogenase family
F2A31_RS10990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F2A31_RS10995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F2A31_RS11005	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS11010	COG1454	alcohol dehydrogenase
F2A31_RS11035	COG0625	glutathione transferase activity
F2A31_RS11065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F2A31_RS11085	COG2072	flavoprotein involved in K transport
F2A31_RS11100	COG1252	NADH dehydrogenase
F2A31_RS11120	COG0251	oxidation-reduction process
F2A31_RS11125	COG2814	Major facilitator Superfamily
F2A31_RS11140	COG0183	Belongs to the thiolase family
F2A31_RS11145	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS11180	COG0583	DNA-binding transcription factor activity
F2A31_RS11185	COG0318	PFAM AMP-dependent synthetase and ligase
F2A31_RS11190	COG1946	Acyl-CoA thioesterase
F2A31_RS11195	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS11210	COG0405	Gamma-glutamyltransferase
F2A31_RS11215	COG2814	Major facilitator Superfamily
F2A31_RS11220	COG1566	PFAM secretion protein HlyD family protein
F2A31_RS11225	COG2050	protein possibly involved in aromatic compounds catabolism
F2A31_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F2A31_RS11240	COG1090	epimerase
F2A31_RS11255	COG1024	Enoyl-CoA hydratase
F2A31_RS11260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F2A31_RS11265	COG0420	3'-5' exonuclease activity
F2A31_RS11295	COG0735	belongs to the Fur family
F2A31_RS11300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F2A31_RS11320	COG0121	glutamine amidotransferase
F2A31_RS11340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F2A31_RS11345	COG0756	dUTP diphosphatase activity
F2A31_RS11350	COG0210	DNA helicase
F2A31_RS11355	COG2885	chlorophyll binding
F2A31_RS11360	COG0204	Acyl-transferase
F2A31_RS11375	COG2894	cell division
F2A31_RS11390	COG1280	lysine exporter protein (LysE YggA)
F2A31_RS11395	COG1674	ftsk spoiiie
F2A31_RS11400	COG0492	ferredoxin-NADP+ reductase activity
F2A31_RS11405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F2A31_RS11415	COG0456	acetyltransferase
F2A31_RS11460	COG1981	membrane
F2A31_RS11470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F2A31_RS11470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F2A31_RS11495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F2A31_RS11515	COG1496	oxidoreductase activity
F2A31_RS11520	COG0564	pseudouridine synthase activity
F2A31_RS11530	COG0358	DNA primase activity
F2A31_RS11545	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F2A31_RS11575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F2A31_RS11610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F2A31_RS11620	COG0351	phosphomethylpyrimidine kinase
F2A31_RS11620	COG0352	thiamine-phosphate diphosphorylase activity
F2A31_RS11620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F2A31_RS11630	COG1652	LysM domain
F2A31_RS11650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F2A31_RS11655	COG1399	metal-binding, possibly nucleic acid-binding protein
F2A31_RS11660	COG3101	peptidyl-lysine hydroxylation
F2A31_RS11665	COG0009	L-threonylcarbamoyladenylate synthase
F2A31_RS11680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F2A31_RS11685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F2A31_RS11720	COG4166	transmembrane transport
F2A31_RS11770	COG4106	trans-aconitate 2-methyltransferase activity
F2A31_RS11790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F2A31_RS11790	COG0596	Alpha beta hydrolase
F2A31_RS11790	COG2226	methyltransferase
F2A31_RS11795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F2A31_RS11810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F2A31_RS11820	COG1196	nuclear chromosome segregation
F2A31_RS11830	COG0730	response to heat
F2A31_RS11845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F2A31_RS11905	COG2358	TRAP transporter, solute receptor (TAXI family
F2A31_RS11920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F2A31_RS11925	COG0489	protein tyrosine kinase activity
F2A31_RS11950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F2A31_RS11950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F2A31_RS11960	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F2A31_RS11980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F2A31_RS11985	COG2081	HI0933 family
F2A31_RS11990	COG0668	transmembrane transport
F2A31_RS12010	COG0583	DNA-binding transcription factor activity
F2A31_RS12030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F2A31_RS12035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F2A31_RS12050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F2A31_RS12065	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F2A31_RS12085	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F2A31_RS12090	COG2199	diguanylate cyclase activity
F2A31_RS12100	COG2205	protein histidine kinase activity
F2A31_RS12105	COG0745	RESPONSE REGULATOR receiver
F2A31_RS12120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F2A31_RS12130	COG0732	type I restriction modification DNA specificity domain
F2A31_RS12155	COG1131	(ABC) transporter
F2A31_RS12165	COG1113	amino acid transport
F2A31_RS12175	COG0625	glutathione transferase activity
F2A31_RS12200	COG2814	Major facilitator Superfamily
F2A31_RS12210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F2A31_RS12215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F2A31_RS12220	COG1309	transcriptional regulator
F2A31_RS12240	COG1063	alcohol dehydrogenase
F2A31_RS12245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F2A31_RS12290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F2A31_RS12295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F2A31_RS12300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F2A31_RS12305	COG2076	Multidrug Resistance protein
F2A31_RS12325	COG2132	Multicopper oxidase
F2A31_RS12335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F2A31_RS12360	COG1968	undecaprenyl-diphosphatase activity
F2A31_RS12365	COG1214	PFAM Peptidase M22, glycoprotease
F2A31_RS12425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F2A31_RS12435	COG1595	DNA-templated transcription, initiation
F2A31_RS12440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F2A31_RS12445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F2A31_RS12510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F2A31_RS12520	COG1764	response to oxidative stress
F2A31_RS12545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F2A31_RS12545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F2A31_RS12560	COG0037	tRNA processing
F2A31_RS12570	COG0248	Ppx GppA phosphatase
F2A31_RS12595	COG0072	phenylalanine-tRNA ligase activity
F2A31_RS12630	COG1238	metal cluster binding
F2A31_RS12645	COG0625	glutathione transferase activity
F2A31_RS12665	COG0318	PFAM AMP-dependent synthetase and ligase
F2A31_RS12670	COG3028	Belongs to the UPF0307 family
F2A31_RS12695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F2A31_RS12700	COG0617	tRNA 3'-terminal CCA addition
F2A31_RS12705	COG1555	photosystem II stabilization
F2A31_RS12710	COG3956	TIGRFAM MazG family protein
F2A31_RS12725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F2A31_RS12745	COG2205	protein histidine kinase activity
F2A31_RS12745	COG0784	Response regulator, receiver
F2A31_RS12745	COG5002	protein histidine kinase activity
F2A31_RS12750	COG1024	Enoyl-CoA hydratase
F2A31_RS12755	COG2084	Dehydrogenase
F2A31_RS12760	COG3622	Belongs to the hyi family
F2A31_RS12770	COG1051	belongs to the nudix hydrolase family
F2A31_RS12810	COG2814	Major facilitator Superfamily
F2A31_RS12815	COG5285	phytanoyl-CoA dioxygenase
F2A31_RS12820	COG1917	Cupin 2, conserved barrel domain protein
F2A31_RS12830	COG0456	acetyltransferase
F2A31_RS12840	COG0431	NADPH-dependent FMN reductase
F2A31_RS12845	COG0798	PFAM Bile acid sodium symporter
F2A31_RS12855	COG0640	Transcriptional regulator
F2A31_RS12870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F2A31_RS12880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F2A31_RS12895	COG0084	hydrolase, TatD family'
F2A31_RS12910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F2A31_RS12945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F2A31_RS12950	COG0440	acetolactate synthase activity
F2A31_RS12955	COG0028	Belongs to the TPP enzyme family
F2A31_RS12975	COG1466	dna polymerase III delta subunit
F2A31_RS12980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F2A31_RS12985	COG1136	(ABC) transporter
F2A31_RS12985	COG0577	efflux transmembrane transporter activity
F2A31_RS12990	COG1538	Outer membrane efflux protein
F2A31_RS13015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F2A31_RS13020	COG1162	GTPase activity
F2A31_RS13030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F2A31_RS13065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F2A31_RS13075	COG3781	membrane
F2A31_RS13110	COG1666	GTP binding
F2A31_RS13120	COG1956	GAF domain-containing protein
F2A31_RS13125	COG1607	acyl-coa hydrolase
F2A31_RS13180	COG1183	phosphatidylcholine synthase activity
F2A31_RS13185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F2A31_RS13215	COG1196	nuclear chromosome segregation
F2A31_RS13215	COG0739	heme binding
F2A31_RS13215	COG0741	lytic transglycosylase activity
F2A31_RS13225	COG1702	phosphate starvation-inducible protein PhoH
F2A31_RS13240	COG4773	Receptor
F2A31_RS13310	COG0788	formyltetrahydrofolate deformylase activity
F2A31_RS13335	COG4651	solute:proton antiporter activity
F2A31_RS13335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F2A31_RS13355	COG0724	RNA recognition motif
F2A31_RS13360	COG0210	DNA helicase
F2A31_RS13385	COG1733	regulation of RNA biosynthetic process
F2A31_RS13390	COG0604	alcohol dehydrogenase
F2A31_RS13395	COG2900	Belongs to the SlyX family
F2A31_RS13400	COG0488	(ABC) transporter
F2A31_RS13415	COG1560	Kdo2-lipid A biosynthetic process
F2A31_RS13490	COG0473	3-isopropylmalate dehydrogenase activity
F2A31_RS13515	COG0583	DNA-binding transcription factor activity
F2A31_RS13525	COG0494	nUDIX hydrolase
F2A31_RS13540	COG3011	Protein conserved in bacteria
F2A31_RS13555	COG0625	glutathione transferase activity
F2A31_RS13570	COG0564	pseudouridine synthase activity
F2A31_RS13580	COG1530	ribonuclease E activity
F2A31_RS13585	COG0318	PFAM AMP-dependent synthetase and ligase
F2A31_RS13600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F2A31_RS13610	COG0534	Mate efflux family protein
F2A31_RS13615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F2A31_RS13650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F2A31_RS13665	COG0493	'glutamate synthase
F2A31_RS13665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F2A31_RS13675	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F2A31_RS13715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F2A31_RS13730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F2A31_RS13740	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
F2A31_RS13740	COG0644	oxidoreductase
F2A31_RS13750	COG1595	DNA-templated transcription, initiation
F2A31_RS13760	COG3220	belongs to the UPF0276 family
F2A31_RS13775	COG0425	Belongs to the sulfur carrier protein TusA family
F2A31_RS13780	COG4535	Mg2 and Co2 transporter CorC
F2A31_RS13785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F2A31_RS13805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F2A31_RS13815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F2A31_RS13825	COG0789	Transcriptional regulator
F2A31_RS13830	COG0598	Magnesium transport protein CorA
F2A31_RS13840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F2A31_RS13845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F2A31_RS13850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F2A31_RS13855	COG1074	ATP-dependent DNA helicase activity
F2A31_RS13860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F2A31_RS13885	COG2226	methyltransferase
F2A31_RS13895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F2A31_RS13900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F2A31_RS13910	COG1116	anion transmembrane transporter activity
F2A31_RS13925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F2A31_RS13940	COG2111	Na H antiporter
F2A31_RS13940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F2A31_RS13945	COG1006	Multisubunit Na H antiporter MnhC subunit
F2A31_RS13950	COG0651	ATP synthesis coupled electron transport
F2A31_RS13955	COG1863	multisubunit Na H antiporter MnhE subunit
F2A31_RS13960	COG2212	antiporter activity
F2A31_RS13965	COG1320	monovalent cation:proton antiporter activity
F2A31_RS13970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F2A31_RS13980	COG0195	Participates in both transcription termination and antitermination
F2A31_RS14030	COG0237	dephospho-CoA kinase activity
F2A31_RS14045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F2A31_RS14055	COG0497	DNA recombination
F2A31_RS14065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F2A31_RS14095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F2A31_RS14155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F2A31_RS14170	COG0326	Molecular chaperone. Has ATPase activity
F2A31_RS14185	COG2056	Na+-H+ antiporter family
F2A31_RS14240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F2A31_RS14290	COG0546	phosphoglycolate phosphatase activity
F2A31_RS14340	COG0181	hydroxymethylbilane synthase activity
F2A31_RS14350	COG3275	phosphorelay sensor kinase activity
F2A31_RS14385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F2A31_RS14390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F2A31_RS14395	COG0772	Belongs to the SEDS family
F2A31_RS14420	COG4974	Belongs to the 'phage' integrase family
F2A31_RS14425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F2A31_RS14435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F2A31_RS14440	COG1686	Belongs to the peptidase S11 family
F2A31_RS14445	COG2197	response regulator
F2A31_RS14460	COG0793	Belongs to the peptidase S41A family
F2A31_RS14465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F2A31_RS14470	COG0795	lipopolysaccharide-transporting ATPase activity
F2A31_RS14475	COG0795	lipopolysaccharide-transporting ATPase activity
F2A31_RS14510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F2A31_RS14510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F2A31_RS14515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F2A31_RS14520	COG0004	ammonium transporteR
F2A31_RS14525	COG0347	Belongs to the P(II) protein family
F2A31_RS14550	COG0494	nUDIX hydrolase
F2A31_RS14570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F2A31_RS14605	COG0606	chelatase, subunit chli
F2A31_RS14625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F2A31_RS14640	COG0318	PFAM AMP-dependent synthetase and ligase
F2A31_RS14655	COG2860	membrane
F2A31_RS14665	COG1253	flavin adenine dinucleotide binding
F2A31_RS14680	COG2814	Major facilitator Superfamily
F2A31_RS14690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F2A31_RS14715	COG2814	Major facilitator Superfamily
F2A31_RS14725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F2A31_RS14730	COG1283	sodium-dependent phosphate transmembrane transporter activity
F2A31_RS14760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F2A31_RS14775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F2A31_RS14780	COG3162	membrane
F2A31_RS14785	COG2205	protein histidine kinase activity
F2A31_RS14810	COG1652	LysM domain
F2A31_RS14815	COG0758	DNA mediated transformation
F2A31_RS14830	COG1309	transcriptional regulator
F2A31_RS14835	COG2814	Major facilitator Superfamily
F2A31_RS14845	COG0386	Belongs to the glutathione peroxidase family
F2A31_RS14870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F2A31_RS14880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F2A31_RS14920	COG1121	(ABC) transporter
F2A31_RS14925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F2A31_RS14930	COG1280	lysine exporter protein (LysE YggA)
F2A31_RS14935	COG2837	iron assimilation
F2A31_RS14970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F2A31_RS14990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F2A31_RS14995	COG0519	Catalyzes the synthesis of GMP from XMP
F2A31_RS14995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F2A31_RS15005	COG4399	Belongs to the UPF0754 family
F2A31_RS15010	COG2259	Doxx family
F2A31_RS15015	COG0586	Pfam SNARE associated Golgi protein
F2A31_RS15030	COG1192	Involved in chromosome partitioning
F2A31_RS15040	COG0271	Belongs to the BolA IbaG family
F2A31_RS15060	COG0477	Major facilitator Superfamily
F2A31_RS15065	COG1024	Enoyl-CoA hydratase
F2A31_RS15070	COG1024	Enoyl-CoA hydratase
F2A31_RS15075	COG1960	acyl-CoA dehydrogenase activity
F2A31_RS15080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F2A31_RS15100	COG1113	amino acid transport
F2A31_RS15105	COG0251	oxidation-reduction process
F2A31_RS15135	COG0456	acetyltransferase
F2A31_RS15145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F2A31_RS15160	COG1204	response to ionizing radiation
F2A31_RS15170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F2A31_RS15195	COG1802	Transcriptional regulator
F2A31_RS15205	COG0277	FAD linked oxidase domain protein
F2A31_RS15220	COG2186	Transcriptional regulator
F2A31_RS15230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F2A31_RS15235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F2A31_RS15250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F2A31_RS15265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F2A31_RS15280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F2A31_RS15285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F2A31_RS15290	COG0438	transferase activity, transferring glycosyl groups
F2A31_RS15340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F2A31_RS15345	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F2A31_RS15385	COG3023	N-Acetylmuramoyl-L-alanine amidase
F2A31_RS15445	COG0546	phosphoglycolate phosphatase activity
F2A31_RS15450	COG1028	Short-chain dehydrogenase reductase Sdr
F2A31_RS15460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F2A31_RS15460	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F2A31_RS15465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F2A31_RS15470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F2A31_RS15475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F2A31_RS15480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F2A31_RS15485	COG1116	anion transmembrane transporter activity
F2A31_RS15490	COG1309	transcriptional regulator
F2A31_RS15495	COG4680	protein conserved in bacteria
F2A31_RS15510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F2A31_RS15520	COG0196	riboflavin kinase activity
F2A31_RS15525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F2A31_RS15535	COG1047	Peptidyl-prolyl cis-trans
F2A31_RS15575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F2A31_RS15580	COG0657	acetylesterase activity
F2A31_RS15600	COG0583	DNA-binding transcription factor activity
F2A31_RS15615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F2A31_RS15640	COG2951	lytic endotransglycosylase activity
F2A31_RS15645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F2A31_RS15665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F2A31_RS15690	COG0583	DNA-binding transcription factor activity
F2A31_RS15695	COG0861	Integral membrane protein TerC family
F2A31_RS15710	COG0402	S-adenosylhomocysteine deaminase activity
F2A31_RS15725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F2A31_RS15735	COG0706	membrane insertase activity