locus-tag	class	description
JFY49_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JFY49_RS00010	COG0592	DNA-directed DNA polymerase activity
JFY49_RS00020	COG0187	DNA topoisomerase II activity
JFY49_RS00030	COG0488	(ABC) transporter
JFY49_RS00065	COG0443	Heat shock 70 kDa protein
JFY49_RS00075	COG0675	Transposase, IS605 OrfB family
JFY49_RS00080	COG0657	acetylesterase activity
JFY49_RS00090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JFY49_RS00140	COG0733	neurotransmitter:sodium symporter activity
JFY49_RS00150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JFY49_RS00160	COG0129	dihydroxy-acid dehydratase activity
JFY49_RS00165	COG0129	dihydroxy-acid dehydratase activity
JFY49_RS00180	COG0675	Transposase, IS605 OrfB family
JFY49_RS00205	COG2233	PERMEase
JFY49_RS00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JFY49_RS00265	COG1064	alcohol dehydrogenase
JFY49_RS00270	COG2818	Glycosylase
JFY49_RS00285	COG1194	a g-specific adenine glycosylase
JFY49_RS00325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JFY49_RS00340	COG0110	maltose O-acetyltransferase activity
JFY49_RS00350	COG0438	transferase activity, transferring glycosyl groups
JFY49_RS00355	COG0438	transferase activity, transferring glycosyl groups
JFY49_RS00360	COG0438	transferase activity, transferring glycosyl groups
JFY49_RS00365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JFY49_RS00370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JFY49_RS00380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JFY49_RS00395	COG1442	glycosyl transferase family 8
JFY49_RS00395	COG1216	Glycosyl transferase, family 2
JFY49_RS00410	COG0297	glycogen (starch) synthase activity
JFY49_RS00410	COG0438	transferase activity, transferring glycosyl groups
JFY49_RS00420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JFY49_RS00425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JFY49_RS00440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JFY49_RS00500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JFY49_RS00510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JFY49_RS00515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JFY49_RS00525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JFY49_RS00535	COG4628	conserved protein (DUF2132)
JFY49_RS00565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JFY49_RS00570	COG3550	peptidyl-serine autophosphorylation
JFY49_RS00690	COG3756	Protein conserved in bacteria
JFY49_RS00725	COG0271	Belongs to the BolA IbaG family
JFY49_RS00735	COG1192	Involved in chromosome partitioning
JFY49_RS00750	COG0586	Pfam SNARE associated Golgi protein
JFY49_RS00765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JFY49_RS00765	COG0519	Catalyzes the synthesis of GMP from XMP
JFY49_RS00815	COG3210	domain, Protein
JFY49_RS00820	COG2831	hemolysin activation secretion protein
JFY49_RS00830	COG4584	PFAM Integrase catalytic
JFY49_RS00835	COG1484	DNA-dependent DNA replication
JFY49_RS00895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JFY49_RS00910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JFY49_RS00915	COG3829	transcription factor binding
JFY49_RS00925	COG1116	anion transmembrane transporter activity
JFY49_RS00930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JFY49_RS00940	COG0534	Mate efflux family protein
JFY49_RS00945	COG0436	Aminotransferase
JFY49_RS00960	COG2837	iron assimilation
JFY49_RS00975	COG1683	Conserved Protein
JFY49_RS00980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JFY49_RS00985	COG1121	(ABC) transporter
JFY49_RS01035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JFY49_RS01070	COG0386	Belongs to the glutathione peroxidase family
JFY49_RS01085	COG0697	spore germination
JFY49_RS01095	COG0758	DNA mediated transformation
JFY49_RS01170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JFY49_RS01195	COG1253	flavin adenine dinucleotide binding
JFY49_RS01205	COG2860	membrane
JFY49_RS01215	COG0477	Major facilitator Superfamily
JFY49_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
JFY49_RS01240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JFY49_RS01260	COG0606	chelatase, subunit chli
JFY49_RS01305	COG4372	Transposase
JFY49_RS01315	COG2433	Pfam Transposase IS66
JFY49_RS01340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JFY49_RS01365	COG0606	chelatase, subunit chli
JFY49_RS01375	COG0347	Belongs to the P(II) protein family
JFY49_RS01380	COG0004	ammonium transporteR
JFY49_RS01390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JFY49_RS01390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JFY49_RS01405	COG0586	Pfam SNARE associated Golgi protein
JFY49_RS01425	COG0795	lipopolysaccharide-transporting ATPase activity
JFY49_RS01430	COG0795	lipopolysaccharide-transporting ATPase activity
JFY49_RS01435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JFY49_RS01440	COG0793	Belongs to the peptidase S41A family
JFY49_RS01465	COG2197	response regulator
JFY49_RS01475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JFY49_RS01485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JFY49_RS01490	COG4974	Belongs to the 'phage' integrase family
JFY49_RS01515	COG0772	Belongs to the SEDS family
JFY49_RS01520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JFY49_RS01525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JFY49_RS01530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JFY49_RS01535	COG0494	nUDIX hydrolase
JFY49_RS01575	COG1289	transmembrane transporter activity
JFY49_RS01590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JFY49_RS01600	COG0497	DNA recombination
JFY49_RS01605	COG3123	guanosine phosphorylase activity
JFY49_RS01610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JFY49_RS01620	COG0237	dephospho-CoA kinase activity
JFY49_RS01680	COG0195	Participates in both transcription termination and antitermination
JFY49_RS01685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JFY49_RS01690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JFY49_RS01695	COG1320	monovalent cation:proton antiporter activity
JFY49_RS01700	COG2212	antiporter activity
JFY49_RS01710	COG0651	ATP synthesis coupled electron transport
JFY49_RS01715	COG1006	Multisubunit Na H antiporter MnhC subunit
JFY49_RS01720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JFY49_RS01720	COG2111	Na H antiporter
JFY49_RS01735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JFY49_RS01760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JFY49_RS01790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JFY49_RS01795	COG1074	ATP-dependent DNA helicase activity
JFY49_RS01800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JFY49_RS01810	COG1185	polyribonucleotide nucleotidyltransferase activity
JFY49_RS01815	COG0598	Magnesium transport protein CorA
JFY49_RS01825	COG0789	Transcriptional regulator
JFY49_RS01845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JFY49_RS01855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JFY49_RS01875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JFY49_RS01880	COG4535	Mg2 and Co2 transporter CorC
JFY49_RS01885	COG0425	Belongs to the sulfur carrier protein TusA family
JFY49_RS01890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
JFY49_RS01890	COG0644	oxidoreductase
JFY49_RS01900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JFY49_RS01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JFY49_RS01925	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JFY49_RS01935	COG0493	'glutamate synthase
JFY49_RS01960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JFY49_RS01985	COG0751	glycine-tRNA ligase activity
JFY49_RS01995	COG0517	IMP dehydrogenase activity
JFY49_RS02000	COG1983	PspC domain protein
JFY49_RS02035	COG0318	PFAM AMP-dependent synthetase and ligase
JFY49_RS02040	COG1530	ribonuclease E activity
JFY49_RS02045	COG0564	pseudouridine synthase activity
JFY49_RS02050	COG0546	phosphoglycolate phosphatase activity
JFY49_RS02060	COG3971	2-oxopent-4-enoate hydratase activity
JFY49_RS02065	COG4569	acetaldehyde dehydrogenase (acetylating) activity
JFY49_RS02095	COG0583	DNA-binding transcription factor activity
JFY49_RS02100	COG4638	Rieske (2fe-2S)
JFY49_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
JFY49_RS02120	COG3384	dioxygenase
JFY49_RS02125	COG0446	pyridine nucleotide-disulphide oxidoreductase
JFY49_RS02150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JFY49_RS02155	COG2826	transposase and inactivated derivatives, IS30 family
JFY49_RS02170	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS02210	COG0583	DNA-binding transcription factor activity
JFY49_RS02225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JFY49_RS02240	COG0473	3-isopropylmalate dehydrogenase activity
JFY49_RS02250	COG3293	Transposase
JFY49_RS02285	COG0252	asparaginase activity
JFY49_RS02320	COG1560	Kdo2-lipid A biosynthetic process
JFY49_RS02325	COG0488	(ABC) transporter
JFY49_RS02330	COG2900	Belongs to the SlyX family
JFY49_RS02365	COG1929	Belongs to the glycerate kinase type-1 family
JFY49_RS02390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JFY49_RS02390	COG4651	solute:proton antiporter activity
JFY49_RS02415	COG0788	formyltetrahydrofolate deformylase activity
JFY49_RS02450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JFY49_RS02475	COG1136	(ABC) transporter
JFY49_RS02475	COG0577	efflux transmembrane transporter activity
JFY49_RS02480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JFY49_RS02510	COG0028	Belongs to the TPP enzyme family
JFY49_RS02545	COG3210	domain, Protein
JFY49_RS02550	COG2831	hemolysin activation secretion protein
JFY49_RS02560	COG4584	PFAM Integrase catalytic
JFY49_RS02565	COG1484	DNA-dependent DNA replication
JFY49_RS02620	COG1426	Protein conserved in bacteria
JFY49_RS02640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JFY49_RS02660	COG3956	TIGRFAM MazG family protein
JFY49_RS02665	COG1555	photosystem II stabilization
JFY49_RS02670	COG0617	tRNA 3'-terminal CCA addition
JFY49_RS02675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JFY49_RS02685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JFY49_RS02690	COG1660	Displays ATPase and GTPase activities
JFY49_RS02695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JFY49_RS02700	COG3028	Belongs to the UPF0307 family
JFY49_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
JFY49_RS02725	COG0625	glutathione transferase activity
JFY49_RS02735	COG1238	metal cluster binding
JFY49_RS02820	COG2813	Specifically methylates the guanine in position
JFY49_RS02820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JFY49_RS02825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JFY49_RS02830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JFY49_RS02835	COG1304	FMN binding
JFY49_RS02840	COG3128	pkhd-type hydroxylase
JFY49_RS02850	COG4774	siderophore transport
JFY49_RS02860	COG4774	siderophore transport
JFY49_RS02870	COG0740	serine-type endopeptidase activity
JFY49_RS02895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JFY49_RS02895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JFY49_RS02905	COG0857	belongs to the CobB CobQ family
JFY49_RS02905	COG0280	phosphate acetyltransferase
JFY49_RS02910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JFY49_RS02940	COG0793	Belongs to the peptidase S41A family
JFY49_RS02960	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JFY49_RS02975	COG0084	hydrolase, TatD family'
JFY49_RS03010	COG1162	GTPase activity
JFY49_RS03015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JFY49_RS03020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JFY49_RS03035	COG0072	phenylalanine-tRNA ligase activity
JFY49_RS03060	COG0248	Ppx GppA phosphatase
JFY49_RS03070	COG0037	tRNA processing
JFY49_RS03110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JFY49_RS03125	COG2853	Lipoprotein
JFY49_RS03160	COG2969	positive regulation of protein catabolic process
JFY49_RS03165	COG0625	glutathione transferase activity
JFY49_RS03170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JFY49_RS03175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JFY49_RS03180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JFY49_RS03185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JFY49_RS03190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JFY49_RS03230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JFY49_RS03240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JFY49_RS03245	COG1408	metallophosphoesterase
JFY49_RS03255	COG0477	Major facilitator Superfamily
JFY49_RS03260	COG1272	protein, Hemolysin III
JFY49_RS03270	COG2153	protein acetylation
JFY49_RS03280	COG1024	Enoyl-CoA hydratase
JFY49_RS03280	COG1250	3-hydroxyacyl-CoA dehydrogenase
JFY49_RS03285	COG0183	Belongs to the thiolase family
JFY49_RS03290	COG2207	Transcriptional regulator
JFY49_RS03295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JFY49_RS03310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JFY49_RS03325	COG0183	Belongs to the thiolase family
JFY49_RS03345	COG0833	amino acid
JFY49_RS03355	COG2233	PERMEase
JFY49_RS03360	COG1217	gtp-binding protein TYPA
JFY49_RS03365	COG1970	mechanosensitive ion channel activity
JFY49_RS03370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JFY49_RS03380	COG4772	TonB-dependent receptor
JFY49_RS03385	COG1902	pentaerythritol trinitrate reductase activity
JFY49_RS03405	COG0354	folic acid binding
JFY49_RS03455	COG0564	pseudouridine synthase activity
JFY49_RS03470	COG0753	catalase activity
JFY49_RS03480	COG3189	MarR family transcriptional regulator
JFY49_RS03485	COG2824	Alkylphosphonate utilization operon protein PhnA
JFY49_RS03495	COG3422	double-strand break repair
JFY49_RS03500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JFY49_RS03500	COG0352	thiamine-phosphate diphosphorylase activity
JFY49_RS03500	COG0351	phosphomethylpyrimidine kinase
JFY49_RS03525	COG0251	oxidation-reduction process
JFY49_RS03530	COG1113	amino acid transport
JFY49_RS03535	COG1981	membrane
JFY49_RS03550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JFY49_RS03565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JFY49_RS03575	COG0456	acetyltransferase
JFY49_RS03585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JFY49_RS03590	COG0492	ferredoxin-NADP+ reductase activity
JFY49_RS03595	COG0531	amino acid
JFY49_RS03595	COG1674	ftsk spoiiie
JFY49_RS03620	COG0850	regulation of cytokinetic process
JFY49_RS03630	COG0204	Acyl-transferase
JFY49_RS03640	COG0210	DNA helicase
JFY49_RS03645	COG0756	dUTP diphosphatase activity
JFY49_RS03660	COG0121	glutamine amidotransferase
JFY49_RS03675	COG2914	Belongs to the UPF0125 (RnfH) family
JFY49_RS03680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JFY49_RS03685	COG0735	belongs to the Fur family
JFY49_RS03715	COG0420	3'-5' exonuclease activity
JFY49_RS03720	COG4251	negative regulation of phosphorylation
JFY49_RS03720	COG3706	GGDEF domain
JFY49_RS03720	COG2203	Gaf domain
JFY49_RS03720	COG5001	Diguanylate cyclase
JFY49_RS03735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JFY49_RS03735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JFY49_RS03755	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
JFY49_RS03795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JFY49_RS03805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JFY49_RS03810	COG1077	Cell shape determining protein MreB Mrl
JFY49_RS03815	COG1792	Involved in formation and maintenance of cell shape
JFY49_RS03825	COG0424	maF-like protein
JFY49_RS03830	COG1530	ribonuclease E activity
JFY49_RS03840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JFY49_RS03875	COG1113	amino acid transport
JFY49_RS03880	COG2828	Protein conserved in bacteria
JFY49_RS03885	COG0142	geranyltranstransferase activity
JFY49_RS03890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JFY49_RS03905	COG1752	Esterase of the alpha-beta hydrolase superfamily
JFY49_RS03935	COG0642	Histidine kinase
JFY49_RS03950	COG0004	ammonium transporteR
JFY49_RS03955	COG1126	abc transporter atp-binding protein
JFY49_RS03960	COG0765	amino acid transport
JFY49_RS03965	COG0765	amino acid transport
JFY49_RS03975	COG2323	membrane
JFY49_RS03990	COG4372	Transposase
JFY49_RS04000	COG2963	transposase activity
JFY49_RS04015	COG0525	valine-tRNA ligase activity
JFY49_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
JFY49_RS04030	COG0393	Putative heavy-metal-binding
JFY49_RS04035	COG0393	Putative heavy-metal-binding
JFY49_RS04040	COG1538	Outer membrane efflux protein
JFY49_RS04050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JFY49_RS04055	COG0671	phosphoesterase, PA-phosphatase related
JFY49_RS04070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JFY49_RS04080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JFY49_RS04090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JFY49_RS04095	COG1648	precorrin-2 dehydrogenase activity
JFY49_RS04095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JFY49_RS04100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JFY49_RS04105	COG0531	amino acid
JFY49_RS04120	COG0321	lipoyl(octanoyl) transferase activity
JFY49_RS04125	COG2921	Belongs to the UPF0250 family
JFY49_RS04130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JFY49_RS04150	COG0586	Pfam SNARE associated Golgi protein
JFY49_RS04170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JFY49_RS04195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JFY49_RS04225	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JFY49_RS04240	COG0358	DNA primase activity
JFY49_RS04250	COG0564	pseudouridine synthase activity
JFY49_RS04265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JFY49_RS04275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JFY49_RS04325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JFY49_RS04330	COG1053	succinate dehydrogenase
JFY49_RS04335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JFY49_RS04350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JFY49_RS04360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JFY49_RS04370	COG1649	PFAM Uncharacterised BCR, COG1649
JFY49_RS04370	COG0726	polysaccharide deacetylase
JFY49_RS04375	COG1215	transferase activity, transferring glycosyl groups
JFY49_RS04385	COG1649	PFAM Uncharacterised BCR, COG1649
JFY49_RS04385	COG0726	polysaccharide deacetylase
JFY49_RS04420	COG1695	Transcriptional regulator
JFY49_RS04435	COG3118	belongs to the thioredoxin family
JFY49_RS04445	COG4221	oxidoreductase activity
JFY49_RS04445	COG0604	alcohol dehydrogenase
JFY49_RS04445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JFY49_RS04445	COG3321	synthase
JFY49_RS04470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JFY49_RS04505	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
JFY49_RS04510	COG1597	lipid kinase activity
JFY49_RS04525	COG0459	protein refolding
JFY49_RS04555	COG1484	DNA-dependent DNA replication
JFY49_RS04620	COG0742	ribosomal rna small subunit methyltransferase
JFY49_RS04625	COG0768	penicillin binding
JFY49_RS04650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JFY49_RS04655	COG2878	Part of a membrane complex involved in electron transport
JFY49_RS04660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JFY49_RS04670	COG3384	dioxygenase
JFY49_RS04680	COG2234	aminopeptidase activity
JFY49_RS04690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JFY49_RS04700	COG2217	Heavy metal translocating P-type atpase
JFY49_RS04725	COG0006	proline dipeptidase activity
JFY49_RS04730	COG2155	Conserved Protein
JFY49_RS04735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JFY49_RS04740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JFY49_RS04760	COG0792	nuclease activity
JFY49_RS04775	COG2816	NAD+ diphosphatase activity
JFY49_RS04785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JFY49_RS04790	COG0741	lytic transglycosylase activity
JFY49_RS04790	COG1388	LysM domain
JFY49_RS04795	COG4166	transmembrane transport
JFY49_RS04800	COG4174	ABC transporter (Permease)
JFY49_RS04805	COG4239	(ABC) transporter, permease
JFY49_RS04810	COG4172	Belongs to the ABC transporter superfamily
JFY49_RS04835	COG0833	amino acid
JFY49_RS04860	COG0418	dihydroorotase activity
JFY49_RS04865	COG3706	GGDEF domain
JFY49_RS04865	COG2203	Gaf domain
JFY49_RS04865	COG4251	negative regulation of phosphorylation
JFY49_RS04865	COG5001	Diguanylate cyclase
JFY49_RS04880	COG2186	Transcriptional regulator
JFY49_RS04890	COG0277	FAD linked oxidase domain protein
JFY49_RS04895	COG0446	pyridine nucleotide-disulphide oxidoreductase
JFY49_RS04895	COG1902	pentaerythritol trinitrate reductase activity
JFY49_RS04935	COG1271	oxidase subunit
JFY49_RS04940	COG1294	oxidase, subunit
JFY49_RS04955	COG0583	DNA-binding transcription factor activity
JFY49_RS04965	COG1741	Belongs to the pirin family
JFY49_RS04980	COG3739	integral membrane protein
JFY49_RS04995	COG3706	GGDEF domain
JFY49_RS05005	COG0302	gtp cyclohydrolase
JFY49_RS05020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JFY49_RS05025	COG0512	Glutamine amidotransferase of anthranilate synthase
JFY49_RS05190	COG1475	DNA binding
JFY49_RS05285	COG3646	Phage regulatory protein
JFY49_RS05395	COG0582	viral genome integration into host DNA
JFY49_RS05400	COG0174	glutamine synthetase
JFY49_RS05415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JFY49_RS05420	COG0583	DNA-binding transcription factor activity
JFY49_RS05460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JFY49_RS05465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JFY49_RS05470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JFY49_RS05495	COG0436	Aminotransferase
JFY49_RS05505	COG0024	Methionine aminopeptidase
JFY49_RS05510	COG0052	Belongs to the universal ribosomal protein uS2 family
JFY49_RS05535	COG2951	lytic endotransglycosylase activity
JFY49_RS05550	COG0842	Transport permease protein
JFY49_RS05555	COG1131	(ABC) transporter
JFY49_RS05565	COG0582	viral genome integration into host DNA
JFY49_RS05835	COG0582	viral genome integration into host DNA
JFY49_RS05890	COG0405	Gamma-glutamyltransferase
JFY49_RS05895	COG0789	Transcriptional regulator
JFY49_RS05965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JFY49_RS05970	COG0730	response to heat
JFY49_RS06005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JFY49_RS06015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JFY49_RS06050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JFY49_RS06050	COG2755	lipolytic protein G-D-S-L family
JFY49_RS06055	COG0436	Aminotransferase
JFY49_RS06060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JFY49_RS06065	COG0386	Belongs to the glutathione peroxidase family
JFY49_RS06090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JFY49_RS06115	COG0012	GTP binding
JFY49_RS06120	COG2011	ABC-type metal ion transport system permease component
JFY49_RS06125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JFY49_RS06130	COG1464	Belongs to the NlpA lipoprotein family
JFY49_RS06135	COG1464	Belongs to the NlpA lipoprotein family
JFY49_RS06195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JFY49_RS06195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JFY49_RS06200	COG1254	Belongs to the acylphosphatase family
JFY49_RS06245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JFY49_RS06250	COG3676	manually curated
JFY49_RS06255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JFY49_RS06575	COG1196	nuclear chromosome segregation
JFY49_RS06575	COG0739	heme binding
JFY49_RS06575	COG0741	lytic transglycosylase activity
JFY49_RS06645	COG0519	Catalyzes the synthesis of GMP from XMP
JFY49_RS06645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JFY49_RS06665	COG1454	alcohol dehydrogenase
JFY49_RS06675	COG1116	anion transmembrane transporter activity
JFY49_RS06675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JFY49_RS06685	COG2223	nitrite transmembrane transporter activity
JFY49_RS06690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JFY49_RS06695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JFY49_RS06700	COG0243	molybdopterin cofactor binding
JFY49_RS06710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JFY49_RS06720	COG0314	molybdopterin synthase activity
JFY49_RS06725	COG0521	Mo-molybdopterin cofactor biosynthetic process
JFY49_RS06725	COG0315	cyclic pyranopterin monophosphate synthase activity
JFY49_RS06730	COG0303	'Molybdopterin
JFY49_RS06735	COG0725	ABC transporter, periplasmic molybdate-binding protein
JFY49_RS06740	COG4149	molybdate abc transporter
JFY49_RS06745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JFY49_RS06770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JFY49_RS06770	COG0517	IMP dehydrogenase activity
JFY49_RS06775	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JFY49_RS06785	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JFY49_RS06790	COG1137	ATPase activity
JFY49_RS06805	COG0589	response to stress
JFY49_RS06810	COG4122	O-methyltransferase activity
JFY49_RS06820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JFY49_RS06825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JFY49_RS06855	COG2011	ABC-type metal ion transport system permease component
JFY49_RS06860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JFY49_RS06865	COG1464	Belongs to the NlpA lipoprotein family
JFY49_RS06875	COG0138	bifunctional purine biosynthesis protein purh
JFY49_RS06880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JFY49_RS06910	COG2814	Major facilitator Superfamily
JFY49_RS06920	COG2204	response regulator
JFY49_RS06925	COG3852	Histidine kinase
JFY49_RS06945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JFY49_RS06950	COG0575	Belongs to the CDS family
JFY49_RS06965	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JFY49_RS06975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JFY49_RS06985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JFY49_RS07000	COG2137	regulation of response to DNA damage stimulus
JFY49_RS07010	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JFY49_RS07015	COG1011	Hydrolase
JFY49_RS07035	COG0702	epimerase
JFY49_RS07040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JFY49_RS07055	COG4585	Histidine kinase
JFY49_RS07060	COG2850	peptidyl-arginine hydroxylation
JFY49_RS07065	COG0424	maF-like protein
JFY49_RS07090	COG0697	spore germination
JFY49_RS07110	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JFY49_RS07120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JFY49_RS07125	COG3781	membrane
JFY49_RS07175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JFY49_RS07180	COG1027	Aspartate ammonia-lyase
JFY49_RS07190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JFY49_RS07220	COG0316	Belongs to the HesB IscA family
JFY49_RS07225	COG0822	iron-sulfur transferase activity
JFY49_RS07250	COG0776	regulation of translation
JFY49_RS07255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JFY49_RS07285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JFY49_RS07305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JFY49_RS07310	COG0569	domain protein
JFY49_RS07315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JFY49_RS07320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JFY49_RS07340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JFY49_RS07345	COG0542	response to heat
JFY49_RS07375	COG0372	Belongs to the citrate synthase family
JFY49_RS07385	COG1546	Belongs to the CinA family
JFY49_RS07385	COG1058	Belongs to the CinA family
JFY49_RS07405	COG0148	phosphopyruvate hydratase activity
JFY49_RS07420	COG0772	Belongs to the SEDS family
JFY49_RS07440	COG4890	Cyd operon protein YbgT
JFY49_RS07445	COG1294	oxidase, subunit
JFY49_RS07495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JFY49_RS07515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JFY49_RS07525	COG0133	tryptophan synthase activity
JFY49_RS07530	COG0516	GMP reductase activity
JFY49_RS07530	COG0517	IMP dehydrogenase activity
JFY49_RS07560	COG0612	Peptidase, M16
JFY49_RS07565	COG0552	protein localization to endoplasmic reticulum
JFY49_RS07610	COG1196	nuclear chromosome segregation
JFY49_RS07610	COG0741	lytic transglycosylase activity
JFY49_RS07610	COG0739	heme binding
JFY49_RS07615	COG0693	protein deglycase activity
JFY49_RS07625	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS07630	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS07680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JFY49_RS07695	COG0730	response to heat
JFY49_RS07700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JFY49_RS07705	COG2207	Transcriptional regulator
JFY49_RS07710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JFY49_RS07780	COG4383	Mu-like prophage protein gp29
JFY49_RS07955	COG3328	transposase activity
JFY49_RS07960	COG0582	viral genome integration into host DNA
JFY49_RS07965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JFY49_RS07980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JFY49_RS08005	COG0583	DNA-binding transcription factor activity
JFY49_RS08025	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JFY49_RS08040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JFY49_RS08060	COG2814	Major facilitator Superfamily
JFY49_RS08075	COG1525	nuclease
JFY49_RS08085	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS08120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JFY49_RS08130	COG1448	Aminotransferase
JFY49_RS08140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JFY49_RS08165	COG1132	(ABC) transporter
JFY49_RS08175	COG0415	Belongs to the DNA photolyase family
JFY49_RS08180	COG0668	transmembrane transport
JFY49_RS08185	COG3122	Protein conserved in bacteria
JFY49_RS08215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JFY49_RS08220	COG0583	DNA-binding transcription factor activity
JFY49_RS08230	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS08235	COG0183	Belongs to the thiolase family
JFY49_RS08240	COG0427	acetyl-CoA hydrolase
JFY49_RS08250	COG0546	phosphoglycolate phosphatase activity
JFY49_RS08260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JFY49_RS08275	COG4770	biotin carboxylase activity
JFY49_RS08280	COG1024	Enoyl-CoA hydratase
JFY49_RS08285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JFY49_RS08290	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS08295	COG1309	transcriptional regulator
JFY49_RS08300	COG0318	PFAM AMP-dependent synthetase and ligase
JFY49_RS08310	COG2223	nitrite transmembrane transporter activity
JFY49_RS08315	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
JFY49_RS08340	COG1944	ATP diphosphatase activity
JFY49_RS08350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JFY49_RS08355	COG0183	Belongs to the thiolase family
JFY49_RS08360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JFY49_RS08365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JFY49_RS08370	COG3135	benzoate transporter
JFY49_RS08375	COG1028	Short-chain dehydrogenase reductase Sdr
JFY49_RS08380	COG0633	Ferredoxin
JFY49_RS08380	COG0543	2 iron, 2 sulfur cluster binding
JFY49_RS08385	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
JFY49_RS08390	COG4638	Rieske (2fe-2S)
JFY49_RS08400	COG4829	muconolactone delta-isomerase
JFY49_RS08405	COG4948	Mandelate Racemase Muconate Lactonizing
JFY49_RS08410	COG0583	DNA-binding transcription factor activity
JFY49_RS08415	COG2814	Major facilitator Superfamily
JFY49_RS08435	COG1136	(ABC) transporter
JFY49_RS08450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JFY49_RS08460	COG2885	chlorophyll binding
JFY49_RS08540	COG0596	Alpha beta hydrolase
JFY49_RS08580	COG0511	ligase activity, forming carbon-carbon bonds
JFY49_RS08585	COG0439	Biotin carboxylase
JFY49_RS08595	COG2814	Major facilitator Superfamily
JFY49_RS08695	COG0446	pyridine nucleotide-disulphide oxidoreductase
JFY49_RS08695	COG1902	pentaerythritol trinitrate reductase activity
JFY49_RS08705	COG2267	carboxylic ester hydrolase activity
JFY49_RS08710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JFY49_RS08715	COG0583	DNA-binding transcription factor activity
JFY49_RS08720	COG0024	Methionine aminopeptidase
JFY49_RS08745	COG2203	Gaf domain
JFY49_RS08745	COG2199	diguanylate cyclase activity
JFY49_RS08790	COG0477	Major facilitator Superfamily
JFY49_RS08815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JFY49_RS08830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JFY49_RS08835	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS08855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JFY49_RS08860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JFY49_RS08865	COG2890	protein-(glutamine-N5) methyltransferase activity
JFY49_RS08870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JFY49_RS08885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JFY49_RS08915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JFY49_RS08920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JFY49_RS08925	COG1845	cytochrome c oxidase, subunit III
JFY49_RS08930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JFY49_RS08940	COG0360	Binds together with S18 to 16S ribosomal RNA
JFY49_RS08945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JFY49_RS08955	COG0305	Participates in initiation and elongation during chromosome replication
JFY49_RS08960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JFY49_RS08970	COG1305	Transglutaminase-like
JFY49_RS08980	COG2308	Evidence 4 Homologs of previously reported genes of
JFY49_RS08990	COG0069	glutamate synthase activity
JFY49_RS09010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JFY49_RS09015	COG1454	alcohol dehydrogenase
JFY49_RS09020	COG0824	Thioesterase
JFY49_RS09025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JFY49_RS09035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JFY49_RS09050	COG0183	Belongs to the thiolase family
JFY49_RS09060	COG0583	DNA-binding transcription factor activity
JFY49_RS09065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JFY49_RS09075	COG3135	benzoate transporter
JFY49_RS09085	COG0589	response to stress
JFY49_RS09090	COG0589	response to stress
JFY49_RS09100	COG0308	aminopeptidase N
JFY49_RS09125	COG1253	flavin adenine dinucleotide binding
JFY49_RS09160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JFY49_RS09175	COG2431	L-lysine efflux transmembrane transporter activity
JFY49_RS09190	COG0776	regulation of translation
JFY49_RS09220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JFY49_RS09235	COG4795	General secretion pathway protein
JFY49_RS09240	COG2165	general secretion pathway protein
JFY49_RS09250	COG1309	transcriptional regulator
JFY49_RS09255	COG0084	hydrolase, TatD family'
JFY49_RS09275	COG1663	tetraacyldisaccharide 4'-kinase activity
JFY49_RS09280	COG1132	(ABC) transporter
JFY49_RS09290	COG0811	peptide transport
JFY49_RS09295	COG1475	DNA binding
JFY49_RS09300	COG1192	Involved in chromosome partitioning
JFY49_RS09310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JFY49_RS09315	COG3178	'Phosphotransferase
JFY49_RS09325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JFY49_RS09330	COG1923	regulation of RNA biosynthetic process
JFY49_RS09340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JFY49_RS09345	COG0802	atpase or kinase
JFY49_RS09370	COG2707	UPF0756 membrane protein
JFY49_RS09375	COG2807	transmembrane transport
JFY49_RS09380	COG0583	DNA-binding transcription factor activity
JFY49_RS09385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JFY49_RS09395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JFY49_RS09400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JFY49_RS09420	COG1643	Atp-dependent helicase
JFY49_RS09445	COG3634	alkyl hydroperoxide reductase activity
JFY49_RS09475	COG2070	2-Nitropropane dioxygenase
JFY49_RS09485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JFY49_RS09520	COG1309	transcriptional regulator
JFY49_RS09560	COG0352	thiamine-phosphate diphosphorylase activity
JFY49_RS09570	COG3025	triphosphatase activity
JFY49_RS09595	COG0612	Peptidase, M16
JFY49_RS09645	COG0515	serine threonine protein kinase
JFY49_RS09645	COG2815	serine threonine protein kinase
JFY49_RS09675	COG1610	YqeY-like protein
JFY49_RS09690	COG4783	chaperone-mediated protein folding
JFY49_RS09720	COG0167	dihydroorotate dehydrogenase activity
JFY49_RS09745	COG0778	Nitroreductase
JFY49_RS09755	COG0513	Belongs to the DEAD box helicase family
JFY49_RS09760	COG1278	Cold shock
JFY49_RS09775	COG2363	Small membrane protein
JFY49_RS09795	COG0625	glutathione transferase activity
JFY49_RS09800	COG0659	secondary active sulfate transmembrane transporter activity
JFY49_RS09805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JFY49_RS09820	COG3047	cAMP biosynthetic process
JFY49_RS09820	COG2885	chlorophyll binding
JFY49_RS09840	COG0540	Belongs to the ATCase OTCase family
JFY49_RS09865	COG0542	response to heat
JFY49_RS09870	COG1765	OsmC-like protein
JFY49_RS09880	COG0667	Aldo Keto reductase
JFY49_RS09895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JFY49_RS09910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JFY49_RS09915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JFY49_RS09920	COG0527	aspartate kinase activity
JFY49_RS09930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JFY49_RS09940	COG3038	cytochrome b561
JFY49_RS09950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JFY49_RS09955	COG2252	PERMEase
JFY49_RS09980	COG0675	Transposase, IS605 OrfB family
JFY49_RS09995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JFY49_RS10000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JFY49_RS10010	COG0693	protein deglycase activity
JFY49_RS10015	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS10020	COG1301	dicarboxylic acid transport
JFY49_RS10025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JFY49_RS10030	COG3139	Protein of unknown function (DUF1315)
JFY49_RS10035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JFY49_RS10040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JFY49_RS10050	COG0494	nUDIX hydrolase
JFY49_RS10060	COG0642	Histidine kinase
JFY49_RS10075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JFY49_RS10085	COG1720	tRNA m6t6A37 methyltransferase activity
JFY49_RS10100	COG0789	Transcriptional regulator
JFY49_RS10105	COG0826	peptidase U32
JFY49_RS10110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JFY49_RS10115	COG3634	alkyl hydroperoxide reductase activity
JFY49_RS10170	COG1966	Carbon starvation protein
JFY49_RS10180	COG1509	lysine 2,3-aminomutase activity
JFY49_RS10215	COG1067	ATP-dependent peptidase activity
JFY49_RS10220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JFY49_RS10225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JFY49_RS10230	COG0583	DNA-binding transcription factor activity
JFY49_RS10265	COG1686	Belongs to the peptidase S11 family
JFY49_RS10270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JFY49_RS10285	COG0482	sulfurtransferase activity
JFY49_RS10290	COG2915	High frequency lysogenization protein hflD homolog
JFY49_RS10305	COG0616	signal peptide processing
JFY49_RS10315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JFY49_RS10325	COG0573	inorganic phosphate transmembrane transporter activity
JFY49_RS10330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JFY49_RS10335	COG0076	glutamate decarboxylase activity
JFY49_RS10340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JFY49_RS10360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JFY49_RS10370	COG2814	Major facilitator Superfamily
JFY49_RS10375	COG1733	regulation of RNA biosynthetic process
JFY49_RS10395	COG0556	nucleotide-excision repair
JFY49_RS10405	COG2199	diguanylate cyclase activity
JFY49_RS10425	COG2175	clavaminate synthase activity
JFY49_RS10445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JFY49_RS10460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JFY49_RS10475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JFY49_RS10480	COG0571	ribonuclease III activity
JFY49_RS10505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JFY49_RS10530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JFY49_RS10540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JFY49_RS10545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JFY49_RS10565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JFY49_RS10570	COG0583	DNA-binding transcription factor activity
JFY49_RS10590	COG0602	queuosine metabolic process
JFY49_RS10595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JFY49_RS10605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JFY49_RS10620	COG2353	YceI-like domain
JFY49_RS10625	COG1051	belongs to the nudix hydrolase family
JFY49_RS10625	COG1056	cytidyltransferase-related domain
JFY49_RS10630	COG1024	Enoyl-CoA hydratase
JFY49_RS10635	COG0778	Nitroreductase
JFY49_RS10640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JFY49_RS10640	COG3323	Protein of unknown function (DUF1653)
JFY49_RS10650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JFY49_RS10650	COG0047	phosphoribosylformylglycinamidine synthase activity
JFY49_RS10665	COG2255	four-way junction helicase activity
JFY49_RS10680	COG1473	amidohydrolase
JFY49_RS10685	COG0824	Thioesterase
JFY49_RS10705	COG0823	Involved in the tonB-independent uptake of proteins
JFY49_RS10725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JFY49_RS10755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JFY49_RS10760	COG0628	permease
JFY49_RS10765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JFY49_RS10770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JFY49_RS10790	COG2333	competence protein COMEC
JFY49_RS10790	COG0658	competence protein
JFY49_RS10795	COG1136	(ABC) transporter
JFY49_RS10800	COG4591	ABC-type transport system involved in lipoprotein release permease component
JFY49_RS10810	COG0697	spore germination
JFY49_RS10815	COG1671	Belongs to the UPF0178 family
JFY49_RS10840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JFY49_RS10855	COG1301	dicarboxylic acid transport
JFY49_RS10875	COG1280	lysine exporter protein (LysE YggA)
JFY49_RS10880	COG1522	sequence-specific DNA binding
JFY49_RS10890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JFY49_RS10900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JFY49_RS10905	COG0019	diaminopimelate decarboxylase activity
JFY49_RS10915	COG1113	amino acid transport
JFY49_RS10945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JFY49_RS10950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JFY49_RS10955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JFY49_RS10980	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JFY49_RS10995	COG0702	epimerase
JFY49_RS11000	COG1733	regulation of RNA biosynthetic process
JFY49_RS11010	COG1902	pentaerythritol trinitrate reductase activity
JFY49_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
JFY49_RS11040	COG4221	oxidoreductase activity
JFY49_RS11040	COG3321	synthase
JFY49_RS11040	COG0604	alcohol dehydrogenase
JFY49_RS11040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JFY49_RS11045	COG0667	Aldo Keto reductase
JFY49_RS11055	COG1902	pentaerythritol trinitrate reductase activity
JFY49_RS11075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JFY49_RS11080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JFY49_RS11090	COG0037	tRNA processing
JFY49_RS11095	COG0739	heme binding
JFY49_RS11095	COG1196	nuclear chromosome segregation
JFY49_RS11095	COG0741	lytic transglycosylase activity
JFY49_RS11100	COG0501	Belongs to the peptidase M48B family
JFY49_RS11130	COG1253	flavin adenine dinucleotide binding
JFY49_RS11170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JFY49_RS11175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JFY49_RS11200	COG0505	Belongs to the CarA family
JFY49_RS11205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JFY49_RS11245	COG3695	enzyme binding
JFY49_RS11260	COG2321	neutral zinc metallopeptidase
JFY49_RS11265	COG2354	Protein conserved in bacteria
JFY49_RS11280	COG3328	transposase activity
JFY49_RS11290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JFY49_RS11295	COG1773	rubredoxin
JFY49_RS11300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JFY49_RS11310	COG0583	DNA-binding transcription factor activity
JFY49_RS11325	COG2433	Pfam Transposase IS66
JFY49_RS11345	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JFY49_RS11350	COG4181	ATPase activity
JFY49_RS11395	COG0306	phosphate transporter
JFY49_RS11415	COG0242	peptide deformylase activity
JFY49_RS11440	COG1024	Enoyl-CoA hydratase
JFY49_RS11465	COG1215	transferase activity, transferring glycosyl groups
JFY49_RS11470	COG0726	polysaccharide deacetylase
JFY49_RS11470	COG1649	PFAM Uncharacterised BCR, COG1649
JFY49_RS11475	COG5001	Diguanylate cyclase
JFY49_RS11475	COG4251	negative regulation of phosphorylation
JFY49_RS11475	COG3706	GGDEF domain
JFY49_RS11475	COG2203	Gaf domain
JFY49_RS11490	COG4681	YaeQ
JFY49_RS11495	COG0523	cobalamin synthesis protein
JFY49_RS11510	COG0583	DNA-binding transcription factor activity
JFY49_RS11515	COG2814	Major facilitator Superfamily
JFY49_RS11525	COG1607	acyl-coa hydrolase
JFY49_RS11535	COG1752	Esterase of the alpha-beta hydrolase superfamily
JFY49_RS11545	COG2814	Major facilitator Superfamily
JFY49_RS11550	COG1289	transmembrane transporter activity
JFY49_RS11560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JFY49_RS11615	COG1376	ErfK ybiS ycfS ynhG family protein
JFY49_RS11620	COG2832	Protein of unknown function (DUF454)
JFY49_RS11650	COG0643	Histidine kinase
JFY49_RS11650	COG2198	Histidine kinase
JFY49_RS11650	COG0784	Response regulator, receiver
JFY49_RS11690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JFY49_RS11700	COG0442	prolyl-tRNA aminoacylation
JFY49_RS11760	COG0489	protein tyrosine kinase activity
JFY49_RS11780	COG4638	Rieske (2fe-2S)
JFY49_RS11790	COG3384	dioxygenase
JFY49_RS11800	COG1012	belongs to the aldehyde dehydrogenase family
JFY49_RS11805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JFY49_RS11815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JFY49_RS11835	COG0514	ATP-dependent DNA helicase (RecQ)
JFY49_RS11855	COG0515	serine threonine protein kinase
JFY49_RS11855	COG2815	serine threonine protein kinase
JFY49_RS12035	COG0582	viral genome integration into host DNA
JFY49_RS12065	COG2814	Major facilitator Superfamily
JFY49_RS12070	COG1566	PFAM secretion protein HlyD family protein
JFY49_RS12085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JFY49_RS12090	COG1090	epimerase
JFY49_RS12110	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JFY49_RS12115	COG2081	HI0933 family
JFY49_RS12130	COG0668	transmembrane transport
JFY49_RS12150	COG0583	DNA-binding transcription factor activity
JFY49_RS12155	COG1278	Cold shock
JFY49_RS12165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JFY49_RS12175	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JFY49_RS12180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JFY49_RS12185	COG0713	ATP synthesis coupled electron transport
JFY49_RS12195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JFY49_RS12210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JFY49_RS12230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JFY49_RS12240	COG2205	protein histidine kinase activity
JFY49_RS12245	COG0745	RESPONSE REGULATOR receiver
JFY49_RS12265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JFY49_RS12275	COG3152	Membrane
JFY49_RS12285	COG2314	TM2 domain
JFY49_RS12295	COG0596	Alpha beta hydrolase
JFY49_RS12305	COG1652	LysM domain
JFY49_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
JFY49_RS12330	COG1399	metal-binding, possibly nucleic acid-binding protein
JFY49_RS12335	COG3101	peptidyl-lysine hydroxylation
JFY49_RS12340	COG0009	L-threonylcarbamoyladenylate synthase
JFY49_RS12355	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JFY49_RS12360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JFY49_RS12375	COG4106	trans-aconitate 2-methyltransferase activity
JFY49_RS12395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JFY49_RS12400	COG2193	ferroxidase activity
JFY49_RS12405	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JFY49_RS12410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JFY49_RS12420	COG1196	nuclear chromosome segregation
JFY49_RS12430	COG0730	response to heat
JFY49_RS12450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JFY49_RS12460	COG1309	transcriptional regulator
JFY49_RS12480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JFY49_RS12495	COG2132	Multicopper oxidase
JFY49_RS12505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JFY49_RS12510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JFY49_RS12525	COG1968	undecaprenyl-diphosphatase activity
JFY49_RS12530	COG1214	PFAM Peptidase M22, glycoprotease
JFY49_RS12540	COG0494	nUDIX hydrolase
JFY49_RS12590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JFY49_RS12595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JFY49_RS12620	COG2433	Pfam Transposase IS66
JFY49_RS12680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JFY49_RS12685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JFY49_RS12700	COG0450	alkyl hydroperoxide reductase
JFY49_RS12720	COG0285	dihydrofolate synthase activity
JFY49_RS12725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JFY49_RS12745	COG0675	Transposase, IS605 OrfB family
JFY49_RS12790	COG4206	TonB-dependent receptor
JFY49_RS12795	COG2096	Adenosyltransferase
JFY49_RS12845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JFY49_RS12855	COG0745	RESPONSE REGULATOR receiver
JFY49_RS12860	COG2205	protein histidine kinase activity
JFY49_RS12870	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS12875	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS12925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JFY49_RS12940	COG0438	transferase activity, transferring glycosyl groups
JFY49_RS12945	COG1215	transferase activity, transferring glycosyl groups
JFY49_RS12960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JFY49_RS12980	COG1215	transferase activity, transferring glycosyl groups
JFY49_RS12985	COG0726	polysaccharide deacetylase
JFY49_RS12995	COG0675	Transposase, IS605 OrfB family
JFY49_RS13005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JFY49_RS13015	COG0675	Transposase, IS605 OrfB family
JFY49_RS13050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JFY49_RS13060	COG1704	LemA family
JFY49_RS13070	COG1862	Preprotein translocase
JFY49_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
JFY49_RS13135	COG2986	histidine ammonia-lyase
JFY49_RS13160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JFY49_RS13165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JFY49_RS13180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JFY49_RS13205	COG1024	Enoyl-CoA hydratase
JFY49_RS13210	COG2084	Dehydrogenase
JFY49_RS13215	COG3622	Belongs to the hyi family
JFY49_RS13240	COG0004	ammonium transporteR
JFY49_RS13270	COG4372	Transposase
JFY49_RS13300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JFY49_RS13315	COG0732	type I restriction modification DNA specificity domain
JFY49_RS13325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JFY49_RS13380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JFY49_RS13390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JFY49_RS13395	COG2003	Belongs to the UPF0758 family
JFY49_RS13400	COG3781	membrane
JFY49_RS13405	COG0613	PHP domain protein
JFY49_RS13445	COG1607	acyl-coa hydrolase
JFY49_RS13480	COG2963	transposase activity
JFY49_RS13490	COG4372	Transposase
JFY49_RS13525	COG1183	phosphatidylcholine synthase activity
JFY49_RS13530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JFY49_RS13565	COG2433	Pfam Transposase IS66
JFY49_RS13590	COG0739	heme binding
JFY49_RS13590	COG0741	lytic transglycosylase activity
JFY49_RS13590	COG1196	nuclear chromosome segregation
JFY49_RS13595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JFY49_RS13600	COG1702	phosphate starvation-inducible protein PhoH
JFY49_RS13660	COG1295	ribonuclease BN
JFY49_RS13665	COG0179	Fumarylacetoacetate (FAA) hydrolase
JFY49_RS13695	COG0557	exoribonuclease II activity
JFY49_RS13700	COG0339	signal peptide processing
JFY49_RS13705	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JFY49_RS13715	COG0697	spore germination
JFY49_RS13740	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JFY49_RS13750	COG2072	flavoprotein involved in K transport
JFY49_RS13765	COG4372	Transposase
JFY49_RS13770	COG0203	ribosomal protein L17
JFY49_RS13775	COG0202	RNA polymerase activity
JFY49_RS13780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JFY49_RS13790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JFY49_RS13815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JFY49_RS13825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JFY49_RS13830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JFY49_RS13835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JFY49_RS13875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JFY49_RS13895	COG0088	Forms part of the polypeptide exit tunnel
JFY49_RS13900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JFY49_RS13915	COG0626	cystathionine gamma-synthase activity
JFY49_RS13925	COG1959	2 iron, 2 sulfur cluster binding
JFY49_RS13940	COG1301	dicarboxylic acid transport
JFY49_RS13945	COG1946	Acyl-CoA thioesterase
JFY49_RS13950	COG2937	Belongs to the GPAT DAPAT family
JFY49_RS13965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JFY49_RS13970	COG1040	competence protein
JFY49_RS13985	COG0598	Magnesium transport protein CorA
JFY49_RS14000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JFY49_RS14005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JFY49_RS14010	COG1127	ABC transporter
JFY49_RS14015	COG0513	Belongs to the DEAD box helicase family
JFY49_RS14035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JFY49_RS14040	COG0408	coproporphyrinogen oxidase activity
JFY49_RS14065	COG1960	acyl-CoA dehydrogenase activity
JFY49_RS14070	COG1278	Cold shock
JFY49_RS14075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JFY49_RS14085	COG0534	Mate efflux family protein
JFY49_RS14090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JFY49_RS14100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JFY49_RS14140	COG0675	Transposase, IS605 OrfB family
JFY49_RS14150	COG2226	methyltransferase
JFY49_RS14160	COG1192	Involved in chromosome partitioning
JFY49_RS14165	COG0628	permease
JFY49_RS14170	COG2032	superoxide dismutase activity
JFY49_RS14175	COG2814	Major facilitator Superfamily
JFY49_RS14195	COG0277	FAD linked oxidase domain protein
JFY49_RS14200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JFY49_RS14220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JFY49_RS14225	COG5380	lipid catabolic process
JFY49_RS14230	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JFY49_RS14240	COG0335	large ribosomal subunit rRNA binding
JFY49_RS14250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JFY49_RS14255	COG0228	four-way junction DNA binding
JFY49_RS14310	COG0194	GDP metabolic process
JFY49_RS14315	COG1758	RNA polymerase activity
JFY49_RS14320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JFY49_RS14340	COG3307	-O-antigen
JFY49_RS14355	COG3307	-O-antigen
JFY49_RS14365	COG4969	Belongs to the N-Me-Phe pilin family
JFY49_RS14380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JFY49_RS14385	COG1704	LemA family
JFY49_RS14395	COG0493	'glutamate synthase
JFY49_RS14400	COG0069	glutamate synthase activity
JFY49_RS14400	COG0070	glutamate synthase
JFY49_RS14400	COG0067	glutamate synthase
JFY49_RS14460	COG2226	methyltransferase
JFY49_RS14465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JFY49_RS14470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JFY49_RS14475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JFY49_RS14495	COG4372	Transposase
JFY49_RS14510	COG3335	DDE superfamily endonuclease
JFY49_RS14525	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JFY49_RS14580	COG0488	(ABC) transporter
JFY49_RS14590	COG4221	oxidoreductase activity
JFY49_RS14615	COG0427	acetyl-CoA hydrolase
JFY49_RS14630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JFY49_RS14665	COG0326	Molecular chaperone. Has ATPase activity
JFY49_RS14675	COG3047	cAMP biosynthetic process
JFY49_RS14680	COG2056	Na+-H+ antiporter family
JFY49_RS14710	COG0085	RNA polymerase activity
JFY49_RS14715	COG0222	ribosome binding
JFY49_RS14720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JFY49_RS14780	COG0546	phosphoglycolate phosphatase activity
JFY49_RS14785	COG1716	ATPase activity
JFY49_RS14830	COG0181	hydroxymethylbilane synthase activity
JFY49_RS14840	COG3275	phosphorelay sensor kinase activity
JFY49_RS14855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JFY49_RS14945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JFY49_RS14965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JFY49_RS14965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JFY49_RS14970	COG0531	amino acid
JFY49_RS14985	COG1278	Cold shock
JFY49_RS14990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JFY49_RS15035	COG0582	viral genome integration into host DNA
JFY49_RS15095	COG0582	viral genome integration into host DNA
JFY49_RS15110	COG3646	Phage regulatory protein
JFY49_RS15125	COG0305	Participates in initiation and elongation during chromosome replication
JFY49_RS15185	COG1570	exodeoxyribonuclease VII activity
JFY49_RS15225	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
JFY49_RS15240	COG0629	single-stranded DNA binding
JFY49_RS15245	COG2814	Major facilitator Superfamily
JFY49_RS15255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JFY49_RS15270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JFY49_RS15305	COG3162	membrane
JFY49_RS15310	COG2205	protein histidine kinase activity
JFY49_RS15310	COG0784	Response regulator, receiver
JFY49_RS15325	COG0431	NADPH-dependent FMN reductase
JFY49_RS15345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JFY49_RS15355	COG0668	transmembrane transport
JFY49_RS15360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JFY49_RS15365	COG1519	Transferase
JFY49_RS15370	COG1902	pentaerythritol trinitrate reductase activity
JFY49_RS15395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JFY49_RS15420	COG0426	domain, Protein
JFY49_RS15420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JFY49_RS15425	COG2119	membrane
JFY49_RS15430	COG0508	dehydrogenase complex catalyzes the overall conversion of
JFY49_RS15455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JFY49_RS15465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JFY49_RS15480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JFY49_RS15485	COG0189	ligase activity
JFY49_RS15505	COG0708	Exodeoxyribonuclease III
JFY49_RS15510	COG1393	Belongs to the ArsC family
JFY49_RS15525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JFY49_RS15530	COG3706	GGDEF domain
JFY49_RS15535	COG0625	glutathione transferase activity
JFY49_RS15560	COG3248	Nucleoside-binding outer membrane protein
JFY49_RS15575	COG3150	esterase
JFY49_RS15585	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JFY49_RS15590	COG2918	glutathione biosynthetic process
JFY49_RS15605	COG2733	membrane
JFY49_RS15655	COG3830	Belongs to the UPF0237 family
JFY49_RS15655	COG0560	Phosphoserine phosphatase
JFY49_RS15665	COG0385	Bile acid
JFY49_RS15670	COG1335	isochorismatase
JFY49_RS15675	COG2814	Major facilitator Superfamily
JFY49_RS15680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JFY49_RS15695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JFY49_RS15700	COG2983	Belongs to the UPF0260 family
JFY49_RS15705	COG5487	UPF0391 membrane protein
JFY49_RS15715	COG3023	N-Acetylmuramoyl-L-alanine amidase
JFY49_RS15725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JFY49_RS15745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JFY49_RS15750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JFY49_RS15755	COG0546	phosphoglycolate phosphatase activity
JFY49_RS15760	COG1028	Short-chain dehydrogenase reductase Sdr
JFY49_RS15775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JFY49_RS15775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JFY49_RS15780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JFY49_RS15785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JFY49_RS15790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JFY49_RS15795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JFY49_RS15800	COG1116	anion transmembrane transporter activity
JFY49_RS15805	COG1309	transcriptional regulator
JFY49_RS15815	COG0196	riboflavin kinase activity
JFY49_RS15820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JFY49_RS15830	COG1047	Peptidyl-prolyl cis-trans
JFY49_RS15845	COG2133	pyrroloquinoline quinone binding
JFY49_RS15850	COG3328	transposase activity
JFY49_RS15855	COG0666	response to abiotic stimulus
JFY49_RS15865	COG2814	Major facilitator Superfamily
JFY49_RS15870	COG2814	Major facilitator Superfamily
JFY49_RS15905	COG0675	Transposase, IS605 OrfB family
JFY49_RS15910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JFY49_RS15915	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JFY49_RS15920	COG2951	lytic endotransglycosylase activity
JFY49_RS15925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JFY49_RS15940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JFY49_RS15945	COG1063	alcohol dehydrogenase
JFY49_RS15955	COG0861	Integral membrane protein TerC family
JFY49_RS15960	COG0402	S-adenosylhomocysteine deaminase activity
JFY49_RS15980	COG1230	cation diffusion facilitator family transporter
JFY49_RS15990	COG2814	Major facilitator Superfamily
JFY49_RS16000	COG0706	membrane insertase activity
JFY49_RS16005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JFY49_RS16010	COG0594	ribonuclease P activity
JFY49_RS16035	COG2801	Transposase and inactivated derivatives
JFY49_RS16085	COG2801	Transposase and inactivated derivatives
JFY49_RS16120	COG1733	regulation of RNA biosynthetic process
JFY49_RS16140	COG4372	Transposase
JFY49_RS16160	COG2963	transposase activity
JFY49_RS16165	COG3421	Type III restriction
JFY49_RS16170	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JFY49_RS16195	COG2826	transposase and inactivated derivatives, IS30 family
JFY49_RS16215	COG0673	inositol 2-dehydrogenase activity
JFY49_RS16225	COG1525	nuclease
JFY49_RS16310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JFY49_RS16505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JFY49_RS16530	COG2826	transposase and inactivated derivatives, IS30 family
JFY49_RS16735	COG1475	DNA binding
JFY49_RS16740	COG1192	Involved in chromosome partitioning
JFY49_RS17045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JFY49_RS17095	COG0583	DNA-binding transcription factor activity
JFY49_RS17105	COG3173	Aminoglycoside phosphotransferase
JFY49_RS17110	COG0488	(ABC) transporter
JFY49_RS17125	COG2801	Transposase and inactivated derivatives
JFY49_RS17135	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JFY49_RS17140	COG3657	addiction module killer protein
JFY49_RS17200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JFY49_RS17220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JFY49_RS17230	COG5002	protein histidine kinase activity
JFY49_RS17235	COG0745	RESPONSE REGULATOR receiver
JFY49_RS17285	COG1660	Displays ATPase and GTPase activities
JFY49_RS17310	COG0860	N-Acetylmuramoyl-L-alanine amidase
JFY49_RS17320	COG4372	Transposase
JFY49_RS17330	COG2963	transposase activity
JFY49_RS17415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone