locus-tag	class	description
HGD77_RS00025	COG1194	a g-specific adenine glycosylase
HGD77_RS00030	COG0739	heme binding
HGD77_RS00040	COG2818	Glycosylase
HGD77_RS00045	COG1064	alcohol dehydrogenase
HGD77_RS00050	COG0675	Transposase, IS605 OrfB family
HGD77_RS00065	COG4372	Transposase
HGD77_RS00105	COG0675	Transposase, IS605 OrfB family
HGD77_RS00145	COG2233	PERMEase
HGD77_RS00165	COG0675	Transposase, IS605 OrfB family
HGD77_RS00170	COG0129	dihydroxy-acid dehydratase activity
HGD77_RS00175	COG0129	dihydroxy-acid dehydratase activity
HGD77_RS00185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGD77_RS00190	COG0428	transporter
HGD77_RS00200	COG0733	neurotransmitter:sodium symporter activity
HGD77_RS00205	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_RS00215	COG0693	protein deglycase activity
HGD77_RS00230	COG2814	Major facilitator Superfamily
HGD77_RS00245	COG2814	Major facilitator Superfamily
HGD77_RS00275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGD77_RS00340	COG0488	(ABC) transporter
HGD77_RS00345	COG1063	alcohol dehydrogenase
HGD77_RS00350	COG0187	DNA topoisomerase II activity
HGD77_RS00360	COG0592	DNA-directed DNA polymerase activity
HGD77_RS00365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGD77_RS00375	COG0594	ribonuclease P activity
HGD77_RS00380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGD77_RS00385	COG0706	membrane insertase activity
HGD77_RS00395	COG3385	transposase activity
HGD77_RS00420	COG0402	S-adenosylhomocysteine deaminase activity
HGD77_RS00430	COG0861	Integral membrane protein TerC family
HGD77_RS00440	COG2388	GCN5-related N-acetyl-transferase
HGD77_RS00465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGD77_RS00485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HGD77_RS00490	COG2951	lytic endotransglycosylase activity
HGD77_RS00495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HGD77_RS00500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGD77_RS00535	COG2133	pyrroloquinoline quinone binding
HGD77_RS00550	COG1047	Peptidyl-prolyl cis-trans
HGD77_RS00555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGD77_RS00560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGD77_RS00565	COG0196	riboflavin kinase activity
HGD77_RS00575	COG1309	transcriptional regulator
HGD77_RS00580	COG1116	anion transmembrane transporter activity
HGD77_RS00585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGD77_RS00590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_RS00595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGD77_RS00600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGD77_RS00605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HGD77_RS00605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HGD77_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS00635	COG0546	phosphoglycolate phosphatase activity
HGD77_RS00640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGD77_RS00645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGD77_RS00655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HGD77_RS00670	COG3023	N-Acetylmuramoyl-L-alanine amidase
HGD77_RS00675	COG0728	peptidoglycan biosynthetic process
HGD77_RS00680	COG5487	UPF0391 membrane protein
HGD77_RS00685	COG2983	Belongs to the UPF0260 family
HGD77_RS00690	COG5001	Diguanylate cyclase
HGD77_RS00690	COG3300	MHYT domain
HGD77_RS00695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGD77_RS00700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGD77_RS00710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGD77_RS00715	COG2814	Major facilitator Superfamily
HGD77_RS00720	COG1335	isochorismatase
HGD77_RS00725	COG0385	Bile acid
HGD77_RS00765	COG0753	catalase activity
HGD77_RS00805	COG2733	membrane
HGD77_RS00820	COG2918	glutathione biosynthetic process
HGD77_RS00825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HGD77_RS00840	COG3150	esterase
HGD77_RS00890	COG1247	-acetyltransferase
HGD77_RS00920	COG3706	GGDEF domain
HGD77_RS00945	COG0708	Exodeoxyribonuclease III
HGD77_RS00950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGD77_RS00955	COG1278	Cold shock
HGD77_RS00970	COG2132	Multicopper oxidase
HGD77_RS00985	COG0189	ligase activity
HGD77_RS01000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGD77_RS01010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HGD77_RS01045	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGD77_RS01050	COG2119	membrane
HGD77_RS01055	COG0426	domain, Protein
HGD77_RS01055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_RS01080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGD77_RS01105	COG1902	pentaerythritol trinitrate reductase activity
HGD77_RS01110	COG1519	Transferase
HGD77_RS01115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGD77_RS01120	COG0668	transmembrane transport
HGD77_RS01125	COG3152	Membrane
HGD77_RS01130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGD77_RS01145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_RS01150	COG0431	NADPH-dependent FMN reductase
HGD77_RS01165	COG2205	protein histidine kinase activity
HGD77_RS01165	COG0784	Response regulator, receiver
HGD77_RS01170	COG3162	membrane
HGD77_RS01195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGD77_RS01205	COG3706	GGDEF domain
HGD77_RS01225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGD77_RS01225	COG0352	thiamine-phosphate diphosphorylase activity
HGD77_RS01225	COG0351	phosphomethylpyrimidine kinase
HGD77_RS01235	COG2814	Major facilitator Superfamily
HGD77_RS01270	COG0641	radical SAM
HGD77_RS01320	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HGD77_RS01395	COG0582	viral genome integration into host DNA
HGD77_RS01405	COG3158	transport of potassium into the cell
HGD77_RS01445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGD77_RS01490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGD77_RS01560	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGD77_RS01560	COG1024	Enoyl-CoA hydratase
HGD77_RS01585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGD77_RS01620	COG0181	hydroxymethylbilane synthase activity
HGD77_RS01670	COG0546	phosphoglycolate phosphatase activity
HGD77_RS01700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGD77_RS01725	COG0081	regulation of translation
HGD77_RS01730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGD77_RS01735	COG0222	ribosome binding
HGD77_RS01740	COG0085	RNA polymerase activity
HGD77_RS01745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGD77_RS01765	COG2056	Na+-H+ antiporter family
HGD77_RS01770	COG3047	cAMP biosynthetic process
HGD77_RS01780	COG0326	Molecular chaperone. Has ATPase activity
HGD77_RS01815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HGD77_RS01820	COG0427	acetyl-CoA hydrolase
HGD77_RS01825	COG2205	protein histidine kinase activity
HGD77_RS01830	COG0745	RESPONSE REGULATOR receiver
HGD77_RS01855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGD77_RS01885	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HGD77_RS01890	COG1074	ATP-dependent DNA helicase activity
HGD77_RS01895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGD77_RS01900	COG3293	Transposase
HGD77_RS01905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGD77_RS01910	COG1185	polyribonucleotide nucleotidyltransferase activity
HGD77_RS01915	COG2841	Protein conserved in bacteria
HGD77_RS01920	COG0789	Transcriptional regulator
HGD77_RS01930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGD77_RS01935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGD77_RS01935	COG0475	glutathione-regulated potassium exporter activity
HGD77_RS01940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGD77_RS01960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGD77_RS01965	COG4535	Mg2 and Co2 transporter CorC
HGD77_RS01970	COG0425	Belongs to the sulfur carrier protein TusA family
HGD77_RS01975	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HGD77_RS01975	COG0644	oxidoreductase
HGD77_RS01985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HGD77_RS02000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGD77_RS02010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HGD77_RS02020	COG0493	'glutamate synthase
HGD77_RS02045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGD77_RS02065	COG0751	glycine-tRNA ligase activity
HGD77_RS02095	COG0471	metal ion transport
HGD77_RS02110	COG1983	PspC domain protein
HGD77_RS02135	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_RS02140	COG1530	ribonuclease E activity
HGD77_RS02145	COG0564	pseudouridine synthase activity
HGD77_RS02150	COG0546	phosphoglycolate phosphatase activity
HGD77_RS02155	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS02160	COG3971	2-oxopent-4-enoate hydratase activity
HGD77_RS02165	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HGD77_RS02195	COG0583	DNA-binding transcription factor activity
HGD77_RS02210	COG4638	Rieske (2fe-2S)
HGD77_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS02230	COG3384	dioxygenase
HGD77_RS02235	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGD77_RS02255	COG3011	Protein conserved in bacteria
HGD77_RS02260	COG0753	catalase activity
HGD77_RS02300	COG0583	DNA-binding transcription factor activity
HGD77_RS02310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HGD77_RS02325	COG0473	3-isopropylmalate dehydrogenase activity
HGD77_RS02385	COG1560	Kdo2-lipid A biosynthetic process
HGD77_RS02395	COG2900	Belongs to the SlyX family
HGD77_RS02430	COG1929	Belongs to the glycerate kinase type-1 family
HGD77_RS02435	COG0210	DNA helicase
HGD77_RS02455	COG4651	solute:proton antiporter activity
HGD77_RS02455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGD77_RS02480	COG0788	formyltetrahydrofolate deformylase activity
HGD77_RS02525	COG3040	lipid binding
HGD77_RS02590	COG2813	Specifically methylates the guanine in position
HGD77_RS02590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGD77_RS02595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGD77_RS02600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGD77_RS02610	COG4774	siderophore transport
HGD77_RS02615	COG4771	TonB-dependent receptor
HGD77_RS02625	COG0740	serine-type endopeptidase activity
HGD77_RS02640	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HGD77_RS02640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HGD77_RS02650	COG0280	phosphate acetyltransferase
HGD77_RS02650	COG0857	belongs to the CobB CobQ family
HGD77_RS02655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGD77_RS02680	COG0793	Belongs to the peptidase S41A family
HGD77_RS02690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HGD77_RS02705	COG0084	hydrolase, TatD family'
HGD77_RS02730	COG1162	GTPase activity
HGD77_RS02735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HGD77_RS02745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HGD77_RS02755	COG1538	Outer membrane efflux protein
HGD77_RS02760	COG1136	(ABC) transporter
HGD77_RS02760	COG0577	efflux transmembrane transporter activity
HGD77_RS02765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_RS02790	COG0028	Belongs to the TPP enzyme family
HGD77_RS02795	COG0440	acetolactate synthase activity
HGD77_RS02800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HGD77_RS02830	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS02860	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS02875	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS02895	COG2975	iron-sulfur cluster assembly
HGD77_RS02915	COG1426	Protein conserved in bacteria
HGD77_RS02935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGD77_RS02950	COG0300	oxidoreductase activity
HGD77_RS02955	COG3956	TIGRFAM MazG family protein
HGD77_RS02960	COG1555	photosystem II stabilization
HGD77_RS02965	COG0617	tRNA 3'-terminal CCA addition
HGD77_RS02970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGD77_RS02985	COG1660	Displays ATPase and GTPase activities
HGD77_RS02990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGD77_RS03000	COG2205	protein histidine kinase activity
HGD77_RS03005	COG0675	Transposase, IS605 OrfB family
HGD77_RS03010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HGD77_RS03065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGD77_RS03105	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS03110	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS03120	COG2205	protein histidine kinase activity
HGD77_RS03125	COG0745	RESPONSE REGULATOR receiver
HGD77_RS03150	COG2096	Adenosyltransferase
HGD77_RS03155	COG4206	TonB-dependent receptor
HGD77_RS03170	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_RS03190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGD77_RS03205	COG0625	glutathione transferase activity
HGD77_RS03215	COG1238	metal cluster binding
HGD77_RS03245	COG0072	phenylalanine-tRNA ligase activity
HGD77_RS03270	COG0248	Ppx GppA phosphatase
HGD77_RS03280	COG0037	tRNA processing
HGD77_RS03335	COG2433	Pfam Transposase IS66
HGD77_RS03345	COG1764	response to oxidative stress
HGD77_RS03350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGD77_RS03415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HGD77_RS03420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGD77_RS03470	COG0494	nUDIX hydrolase
HGD77_RS03480	COG1214	PFAM Peptidase M22, glycoprotease
HGD77_RS03485	COG1968	undecaprenyl-diphosphatase activity
HGD77_RS03505	COG4269	membrane
HGD77_RS03520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGD77_RS03530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGD77_RS03545	COG2814	Major facilitator Superfamily
HGD77_RS03550	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_RS03550	COG2030	dehydratase
HGD77_RS03555	COG3396	Phenylacetate-CoA oxygenase
HGD77_RS03560	COG3460	Phenylacetate-CoA oxygenase
HGD77_RS03565	COG3396	Phenylacetate-CoA oxygenase
HGD77_RS03570	COG2151	metal-sulfur cluster biosynthetic enzyme
HGD77_RS03575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGD77_RS03580	COG1024	Enoyl-CoA hydratase
HGD77_RS03585	COG1024	Enoyl-CoA hydratase
HGD77_RS03590	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGD77_RS03595	COG0183	Belongs to the thiolase family
HGD77_RS03600	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HGD77_RS03605	COG3327	negative regulation of DNA-templated transcription, initiation
HGD77_RS03615	COG4106	trans-aconitate 2-methyltransferase activity
HGD77_RS03625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGD77_RS03650	COG0730	response to heat
HGD77_RS03660	COG1196	nuclear chromosome segregation
HGD77_RS03670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGD77_RS03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGD77_RS03685	COG2193	ferroxidase activity
HGD77_RS03755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGD77_RS03760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGD77_RS03775	COG0009	L-threonylcarbamoyladenylate synthase
HGD77_RS03780	COG3101	peptidyl-lysine hydroxylation
HGD77_RS03785	COG1399	metal-binding, possibly nucleic acid-binding protein
HGD77_RS03795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGD77_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS03805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGD77_RS03810	COG1652	LysM domain
HGD77_RS03830	COG0251	oxidation-reduction process
HGD77_RS03835	COG1113	amino acid transport
HGD77_RS03855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGD77_RS03870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGD77_RS03880	COG0456	acetyltransferase
HGD77_RS03890	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HGD77_RS03895	COG0492	ferredoxin-NADP+ reductase activity
HGD77_RS03900	COG1674	ftsk spoiiie
HGD77_RS03900	COG0531	amino acid
HGD77_RS03930	COG0204	Acyl-transferase
HGD77_RS03935	COG2885	chlorophyll binding
HGD77_RS03940	COG0210	DNA helicase
HGD77_RS03945	COG0756	dUTP diphosphatase activity
HGD77_RS03950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGD77_RS03955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HGD77_RS03960	COG0121	glutamine amidotransferase
HGD77_RS03975	COG2914	Belongs to the UPF0125 (RnfH) family
HGD77_RS03980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGD77_RS03985	COG0735	belongs to the Fur family
HGD77_RS04015	COG0420	3'-5' exonuclease activity
HGD77_RS04025	COG0702	epimerase
HGD77_RS04030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGD77_RS04040	COG2050	protein possibly involved in aromatic compounds catabolism
HGD77_RS04045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGD77_RS04055	COG0582	viral genome integration into host DNA
HGD77_RS04065	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS04075	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS04080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGD77_RS04090	COG3177	Filamentation induced by cAMP protein fic
HGD77_RS04125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_RS04130	COG4591	ABC-type transport system involved in lipoprotein release permease component
HGD77_RS04135	COG1136	(ABC) transporter
HGD77_RS04140	COG0783	Belongs to the Dps family
HGD77_RS04165	COG0500	methyltransferase
HGD77_RS04175	COG2223	nitrite transmembrane transporter activity
HGD77_RS04180	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HGD77_RS04215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGD77_RS04225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGD77_RS04230	COG1077	Cell shape determining protein MreB Mrl
HGD77_RS04235	COG1792	Involved in formation and maintenance of cell shape
HGD77_RS04240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HGD77_RS04245	COG0424	maF-like protein
HGD77_RS04250	COG1530	ribonuclease E activity
HGD77_RS04270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGD77_RS04305	COG1113	amino acid transport
HGD77_RS04310	COG2828	Protein conserved in bacteria
HGD77_RS04315	COG0142	geranyltranstransferase activity
HGD77_RS04320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGD77_RS04335	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGD77_RS04360	COG3335	DDE superfamily endonuclease
HGD77_RS04375	COG2323	membrane
HGD77_RS04410	COG0525	valine-tRNA ligase activity
HGD77_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS04430	COG2066	Belongs to the glutaminase family
HGD77_RS04450	COG0306	phosphate transporter
HGD77_RS04475	COG4771	TonB-dependent receptor
HGD77_RS04500	COG4181	ATPase activity
HGD77_RS04505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HGD77_RS04515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGD77_RS04530	COG0583	DNA-binding transcription factor activity
HGD77_RS04535	COG2267	carboxylic ester hydrolase activity
HGD77_RS04540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_RS04545	COG1773	rubredoxin
HGD77_RS04550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGD77_RS04570	COG2354	Protein conserved in bacteria
HGD77_RS04575	COG2321	neutral zinc metallopeptidase
HGD77_RS04600	COG0589	response to stress
HGD77_RS04635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HGD77_RS04640	COG1053	succinate dehydrogenase
HGD77_RS04645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HGD77_RS04660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGD77_RS04670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HGD77_RS04675	COG3385	transposase activity
HGD77_RS04680	COG2268	Band 7 protein
HGD77_RS04710	COG3118	belongs to the thioredoxin family
HGD77_RS04715	COG3321	synthase
HGD77_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS04715	COG0604	alcohol dehydrogenase
HGD77_RS04740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGD77_RS04760	COG1597	lipid kinase activity
HGD77_RS04820	COG0742	ribosomal rna small subunit methyltransferase
HGD77_RS04825	COG0768	penicillin binding
HGD77_RS04850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGD77_RS04855	COG2878	Part of a membrane complex involved in electron transport
HGD77_RS04860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HGD77_RS04870	COG3384	dioxygenase
HGD77_RS04880	COG2234	aminopeptidase activity
HGD77_RS04890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGD77_RS04915	COG1802	Transcriptional regulator
HGD77_RS04950	COG0006	proline dipeptidase activity
HGD77_RS04955	COG2155	Conserved Protein
HGD77_RS04965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGD77_RS04970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGD77_RS04985	COG3107	peptidoglycan biosynthetic process
HGD77_RS05025	COG1388	LysM domain
HGD77_RS05025	COG0741	lytic transglycosylase activity
HGD77_RS05025	COG0741	lytic transglycosylase activity
HGD77_RS05025	COG1388	LysM domain
HGD77_RS05030	COG4166	transmembrane transport
HGD77_RS05035	COG4174	ABC transporter (Permease)
HGD77_RS05040	COG4239	(ABC) transporter, permease
HGD77_RS05080	COG0833	amino acid
HGD77_RS05105	COG0418	dihydroorotase activity
HGD77_RS05115	COG4251	negative regulation of phosphorylation
HGD77_RS05115	COG5001	Diguanylate cyclase
HGD77_RS05115	COG2203	Gaf domain
HGD77_RS05115	COG3706	GGDEF domain
HGD77_RS05130	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGD77_RS05130	COG1902	pentaerythritol trinitrate reductase activity
HGD77_RS05150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGD77_RS05170	COG0582	viral genome integration into host DNA
HGD77_RS05180	COG1741	Belongs to the pirin family
HGD77_RS05195	COG3739	integral membrane protein
HGD77_RS05210	COG3706	GGDEF domain
HGD77_RS05240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HGD77_RS05245	COG0512	Glutamine amidotransferase of anthranilate synthase
HGD77_RS05430	COG0174	glutamine synthetase
HGD77_RS05445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HGD77_RS05485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGD77_RS05490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGD77_RS05495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGD77_RS05505	COG0596	Alpha beta hydrolase
HGD77_RS05510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_RS05515	COG1335	isochorismatase
HGD77_RS05520	COG0251	oxidation-reduction process
HGD77_RS05525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_RS05530	COG2233	PERMEase
HGD77_RS05535	COG2084	Dehydrogenase
HGD77_RS05550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGD77_RS05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGD77_RS05565	COG2175	clavaminate synthase activity
HGD77_RS05590	COG0556	nucleotide-excision repair
HGD77_RS05615	COG1733	regulation of RNA biosynthetic process
HGD77_RS05625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGD77_RS05645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGD77_RS05650	COG0076	glutamate decarboxylase activity
HGD77_RS05655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HGD77_RS05660	COG0573	inorganic phosphate transmembrane transporter activity
HGD77_RS05670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HGD77_RS05675	COG0616	signal peptide processing
HGD77_RS05705	COG0482	sulfurtransferase activity
HGD77_RS05725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HGD77_RS05730	COG1686	Belongs to the peptidase S11 family
HGD77_RS05745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HGD77_RS05755	COG0583	DNA-binding transcription factor activity
HGD77_RS05760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGD77_RS05765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HGD77_RS05790	COG0254	rRNA binding
HGD77_RS05805	COG1509	lysine 2,3-aminomutase activity
HGD77_RS05810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGD77_RS05815	COG1966	Carbon starvation protein
HGD77_RS05820	COG2879	small protein
HGD77_RS05830	COG0714	Associated with various cellular activities
HGD77_RS05845	COG2433	Pfam Transposase IS66
HGD77_RS05875	COG2199	diguanylate cyclase activity
HGD77_RS05875	COG2203	Gaf domain
HGD77_RS05895	COG0640	Transcriptional regulator
HGD77_RS05905	COG0798	PFAM Bile acid sodium symporter
HGD77_RS05910	COG0431	NADPH-dependent FMN reductase
HGD77_RS05915	COG2072	flavoprotein involved in K transport
HGD77_RS05920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGD77_RS05930	COG0642	Histidine kinase
HGD77_RS05945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGD77_RS05960	COG0640	Transcriptional regulator
HGD77_RS05995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HGD77_RS06000	COG1765	OsmC-like protein
HGD77_RS06010	COG0667	Aldo Keto reductase
HGD77_RS06035	COG0540	Belongs to the ATCase OTCase family
HGD77_RS06050	COG2031	fatty acid transporter
HGD77_RS06055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGD77_RS06070	COG4770	biotin carboxylase activity
HGD77_RS06075	COG1024	Enoyl-CoA hydratase
HGD77_RS06080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGD77_RS06085	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS06090	COG1309	transcriptional regulator
HGD77_RS06095	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_RS06115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGD77_RS06120	COG0659	secondary active sulfate transmembrane transporter activity
HGD77_RS06125	COG0625	glutathione transferase activity
HGD77_RS06140	COG2363	Small membrane protein
HGD77_RS06155	COG1278	Cold shock
HGD77_RS06160	COG0513	Belongs to the DEAD box helicase family
HGD77_RS06170	COG0778	Nitroreductase
HGD77_RS06195	COG0167	dihydroorotate dehydrogenase activity
HGD77_RS06210	COG0501	Belongs to the peptidase M48B family
HGD77_RS06235	COG1610	YqeY-like protein
HGD77_RS06250	COG2199	diguanylate cyclase activity
HGD77_RS06250	COG2203	Gaf domain
HGD77_RS06265	COG4372	Transposase
HGD77_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGD77_RS06360	COG0612	Peptidase, M16
HGD77_RS06380	COG3025	triphosphatase activity
HGD77_RS06395	COG0352	thiamine-phosphate diphosphorylase activity
HGD77_RS06440	COG1309	transcriptional regulator
HGD77_RS06475	COG2070	2-Nitropropane dioxygenase
HGD77_RS06495	COG2391	methyltransferase activity
HGD77_RS06505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGD77_RS06515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGD77_RS06540	COG0505	Belongs to the CarA family
HGD77_RS06545	COG0625	glutathione transferase activity
HGD77_RS06575	COG0517	IMP dehydrogenase activity
HGD77_RS06575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HGD77_RS06580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HGD77_RS06590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HGD77_RS06595	COG1137	ATPase activity
HGD77_RS06630	COG4122	O-methyltransferase activity
HGD77_RS06640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HGD77_RS06680	COG2011	ABC-type metal ion transport system permease component
HGD77_RS06685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGD77_RS06690	COG1464	Belongs to the NlpA lipoprotein family
HGD77_RS06710	COG0138	bifunctional purine biosynthesis protein purh
HGD77_RS06715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HGD77_RS06750	COG2814	Major facilitator Superfamily
HGD77_RS06765	COG3852	Histidine kinase
HGD77_RS06785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGD77_RS06790	COG0575	Belongs to the CDS family
HGD77_RS06805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGD77_RS06820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGD77_RS06825	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGD77_RS06840	COG2137	regulation of response to DNA damage stimulus
HGD77_RS06845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGD77_RS06850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HGD77_RS06855	COG1011	Hydrolase
HGD77_RS06870	COG0268	Binds directly to 16S ribosomal RNA
HGD77_RS06875	COG0702	epimerase
HGD77_RS06880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HGD77_RS06890	COG2197	response regulator
HGD77_RS06895	COG4585	Histidine kinase
HGD77_RS06900	COG2850	peptidyl-arginine hydroxylation
HGD77_RS06905	COG0424	maF-like protein
HGD77_RS06930	COG0697	spore germination
HGD77_RS06940	COG0778	Nitroreductase
HGD77_RS06985	COG3781	membrane
HGD77_RS07015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGD77_RS07020	COG1027	Aspartate ammonia-lyase
HGD77_RS07030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGD77_RS07060	COG0316	Belongs to the HesB IscA family
HGD77_RS07065	COG0822	iron-sulfur transferase activity
HGD77_RS07090	COG0776	regulation of translation
HGD77_RS07095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGD77_RS07115	COG1585	Membrane protein implicated in regulation of membrane protease activity
HGD77_RS07125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGD77_RS07145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGD77_RS07150	COG0569	domain protein
HGD77_RS07155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HGD77_RS07160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGD77_RS07180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGD77_RS07185	COG0542	response to heat
HGD77_RS07215	COG0372	Belongs to the citrate synthase family
HGD77_RS07275	COG2814	Major facilitator Superfamily
HGD77_RS07295	COG0439	Biotin carboxylase
HGD77_RS07305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HGD77_RS07310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGD77_RS07345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGD77_RS07375	COG0596	Alpha beta hydrolase
HGD77_RS07420	COG0642	Histidine kinase
HGD77_RS07425	COG0745	RESPONSE REGULATOR receiver
HGD77_RS07430	COG2194	sulfuric ester hydrolase activity
HGD77_RS07445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_RS07500	COG0583	DNA-binding transcription factor activity
HGD77_RS07505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGD77_RS07525	COG2233	PERMEase
HGD77_RS07530	COG2351	hydroxyisourate hydrolase activity
HGD77_RS07560	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_RS07565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGD77_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS07605	COG1024	Enoyl-CoA hydratase
HGD77_RS07610	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS07615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGD77_RS07630	COG0583	DNA-binding transcription factor activity
HGD77_RS07665	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_RS07680	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS07690	COG1024	Enoyl-CoA hydratase
HGD77_RS07695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGD77_RS07700	COG0235	Class ii aldolase
HGD77_RS07710	COG0183	Belongs to the thiolase family
HGD77_RS07720	COG1024	Enoyl-CoA hydratase
HGD77_RS07725	COG2814	Major facilitator Superfamily
HGD77_RS07735	COG2814	Major facilitator Superfamily
HGD77_RS07740	COG5001	Diguanylate cyclase
HGD77_RS07745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGD77_RS07750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGD77_RS07755	COG2814	Major facilitator Superfamily
HGD77_RS07760	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS07765	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS07775	COG0644	oxidoreductase
HGD77_RS07775	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HGD77_RS07780	COG1944	ATP diphosphatase activity
HGD77_RS07800	COG1309	transcriptional regulator
HGD77_RS07815	COG4771	TonB-dependent receptor
HGD77_RS07820	COG0583	DNA-binding transcription factor activity
HGD77_RS07835	COG0515	serine threonine protein kinase
HGD77_RS07840	COG2116	formate transmembrane transporter activity
HGD77_RS07845	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HGD77_RS07850	COG2223	nitrite transmembrane transporter activity
HGD77_RS07855	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HGD77_RS07860	COG4149	molybdate abc transporter
HGD77_RS07865	COG0725	ABC transporter, periplasmic molybdate-binding protein
HGD77_RS07870	COG0303	'Molybdopterin
HGD77_RS07875	COG0315	cyclic pyranopterin monophosphate synthase activity
HGD77_RS07875	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGD77_RS07880	COG0314	molybdopterin synthase activity
HGD77_RS07890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGD77_RS07900	COG0243	molybdopterin cofactor binding
HGD77_RS07905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_RS07910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_RS07920	COG1116	anion transmembrane transporter activity
HGD77_RS07920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGD77_RS07925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGD77_RS07945	COG1064	alcohol dehydrogenase
HGD77_RS07970	COG0864	Transcriptional regulator
HGD77_RS07975	COG1196	nuclear chromosome segregation
HGD77_RS07980	COG0439	Biotin carboxylase
HGD77_RS08000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGD77_RS08015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGD77_RS08015	COG1017	nitric oxide dioxygenase activity
HGD77_RS08020	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_RS08025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGD77_RS08035	COG2814	Major facilitator Superfamily
HGD77_RS08040	COG0583	DNA-binding transcription factor activity
HGD77_RS08045	COG4948	Mandelate Racemase Muconate Lactonizing
HGD77_RS08050	COG4829	muconolactone delta-isomerase
HGD77_RS08070	COG4638	Rieske (2fe-2S)
HGD77_RS08075	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HGD77_RS08080	COG0633	Ferredoxin
HGD77_RS08080	COG0543	2 iron, 2 sulfur cluster binding
HGD77_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS08090	COG3135	benzoate transporter
HGD77_RS08095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGD77_RS08100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGD77_RS08105	COG0183	Belongs to the thiolase family
HGD77_RS08110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGD77_RS08135	COG0183	Belongs to the thiolase family
HGD77_RS08140	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS08155	COG0789	Transcriptional regulator
HGD77_RS08165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGD77_RS08180	COG0640	Transcriptional regulator
HGD77_RS08200	COG3122	Protein conserved in bacteria
HGD77_RS08205	COG0668	transmembrane transport
HGD77_RS08210	COG1132	(ABC) transporter
HGD77_RS08220	COG0509	glycine decarboxylation via glycine cleavage system
HGD77_RS08225	COG2814	Major facilitator Superfamily
HGD77_RS08240	COG2801	Transposase and inactivated derivatives
HGD77_RS08245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGD77_RS08255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HGD77_RS08260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGD77_RS08325	COG1525	nuclease
HGD77_RS08335	COG1294	oxidase, subunit
HGD77_RS08340	COG1271	oxidase subunit
HGD77_RS08355	COG2169	Transcriptional regulator
HGD77_RS08360	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS08365	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGD77_RS08370	COG2207	Transcriptional regulator
HGD77_RS08375	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGD77_RS08380	COG0730	response to heat
HGD77_RS08385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGD77_RS08450	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS08455	COG0456	acetyltransferase
HGD77_RS08490	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HGD77_RS08505	COG0552	protein localization to endoplasmic reticulum
HGD77_RS08510	COG0612	Peptidase, M16
HGD77_RS08540	COG0517	IMP dehydrogenase activity
HGD77_RS08545	COG0133	tryptophan synthase activity
HGD77_RS08555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGD77_RS08575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGD77_RS08605	COG0537	adenosine 5'-monophosphoramidase activity
HGD77_RS08630	COG1294	oxidase, subunit
HGD77_RS08635	COG4890	Cyd operon protein YbgT
HGD77_RS08645	COG3385	transposase activity
HGD77_RS08650	COG0772	Belongs to the SEDS family
HGD77_RS08665	COG0148	phosphopyruvate hydratase activity
HGD77_RS08710	COG1902	pentaerythritol trinitrate reductase activity
HGD77_RS08710	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGD77_RS08725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HGD77_RS08730	COG0583	DNA-binding transcription factor activity
HGD77_RS08810	COG1570	exodeoxyribonuclease VII activity
HGD77_RS08820	COG3385	transposase activity
HGD77_RS08865	COG0729	surface antigen
HGD77_RS08870	COG0477	Major facilitator Superfamily
HGD77_RS08885	COG3293	Transposase
HGD77_RS08920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGD77_RS08930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGD77_RS08935	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS08955	COG2890	protein-(glutamine-N5) methyltransferase activity
HGD77_RS08960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGD77_RS08975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_RS09000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGD77_RS09005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGD77_RS09010	COG1845	cytochrome c oxidase, subunit III
HGD77_RS09015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGD77_RS09025	COG0360	Binds together with S18 to 16S ribosomal RNA
HGD77_RS09040	COG0305	Participates in initiation and elongation during chromosome replication
HGD77_RS09045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGD77_RS09060	COG1305	Transglutaminase-like
HGD77_RS09070	COG2308	Evidence 4 Homologs of previously reported genes of
HGD77_RS09080	COG0069	glutamate synthase activity
HGD77_RS09100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGD77_RS09105	COG1454	alcohol dehydrogenase
HGD77_RS09110	COG0824	Thioesterase
HGD77_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_RS09140	COG0183	Belongs to the thiolase family
HGD77_RS09155	COG0583	DNA-binding transcription factor activity
HGD77_RS09160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HGD77_RS09170	COG3135	benzoate transporter
HGD77_RS09185	COG0589	response to stress
HGD77_RS09190	COG0589	response to stress
HGD77_RS09200	COG0308	aminopeptidase N
HGD77_RS09225	COG1253	flavin adenine dinucleotide binding
HGD77_RS09245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HGD77_RS09250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HGD77_RS09265	COG2431	L-lysine efflux transmembrane transporter activity
HGD77_RS09280	COG0776	regulation of translation
HGD77_RS09340	COG1309	transcriptional regulator
HGD77_RS09345	COG0084	hydrolase, TatD family'
HGD77_RS09365	COG1663	tetraacyldisaccharide 4'-kinase activity
HGD77_RS09385	COG1475	DNA binding
HGD77_RS09400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGD77_RS09405	COG3178	'Phosphotransferase
HGD77_RS09415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGD77_RS09420	COG1923	regulation of RNA biosynthetic process
HGD77_RS09430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGD77_RS09435	COG0802	atpase or kinase
HGD77_RS09470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGD77_RS09490	COG1643	Atp-dependent helicase
HGD77_RS09515	COG3634	alkyl hydroperoxide reductase activity
HGD77_RS09545	COG1254	Belongs to the acylphosphatase family
HGD77_RS09575	COG0582	viral genome integration into host DNA
HGD77_RS09605	COG4372	Transposase
HGD77_RS09630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGD77_RS09655	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HGD77_RS09670	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HGD77_RS09675	COG1116	anion transmembrane transporter activity
HGD77_RS09680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGD77_RS09685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGD77_RS09735	COG0204	Acyl-transferase
HGD77_RS09775	COG0012	GTP binding
HGD77_RS09790	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HGD77_RS09810	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HGD77_RS09815	COG0436	Aminotransferase
HGD77_RS09820	COG0386	Belongs to the glutathione peroxidase family
HGD77_RS09825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGD77_RS09830	COG0436	Aminotransferase
HGD77_RS09855	COG2351	hydroxyisourate hydrolase activity
HGD77_RS09875	COG1686	Belongs to the peptidase S11 family
HGD77_RS09885	COG1252	NADH dehydrogenase
HGD77_RS09905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGD77_RS09920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HGD77_RS09935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGD77_RS09940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGD77_RS09945	COG0527	aspartate kinase activity
HGD77_RS09955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGD77_RS09975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HGD77_RS09980	COG2252	PERMEase
HGD77_RS10005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGD77_RS10010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGD77_RS10020	COG0693	protein deglycase activity
HGD77_RS10030	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS10035	COG1301	dicarboxylic acid transport
HGD77_RS10045	COG3139	Protein of unknown function (DUF1315)
HGD77_RS10050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGD77_RS10055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGD77_RS10065	COG0494	nUDIX hydrolase
HGD77_RS10075	COG0642	Histidine kinase
HGD77_RS10080	COG0745	RESPONSE REGULATOR receiver
HGD77_RS10090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HGD77_RS10100	COG1720	tRNA m6t6A37 methyltransferase activity
HGD77_RS10135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGD77_RS10140	COG3634	alkyl hydroperoxide reductase activity
HGD77_RS10160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGD77_RS10215	COG3706	GGDEF domain
HGD77_RS10225	COG1131	(ABC) transporter
HGD77_RS10230	COG0842	Transport permease protein
HGD77_RS10245	COG2951	lytic endotransglycosylase activity
HGD77_RS10270	COG0052	Belongs to the universal ribosomal protein uS2 family
HGD77_RS10280	COG0436	Aminotransferase
HGD77_RS10285	COG0534	Mate efflux family protein
HGD77_RS10310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HGD77_RS10325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGD77_RS10330	COG0571	ribonuclease III activity
HGD77_RS10355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGD77_RS10405	COG2433	Pfam Transposase IS66
HGD77_RS10440	COG2433	Pfam Transposase IS66
HGD77_RS10490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGD77_RS10500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGD77_RS10505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGD77_RS10520	COG4208	sulfate ABC transporter
HGD77_RS10525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HGD77_RS10530	COG0583	DNA-binding transcription factor activity
HGD77_RS10550	COG0602	queuosine metabolic process
HGD77_RS10555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGD77_RS10565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGD77_RS10570	COG2353	YceI-like domain
HGD77_RS10580	COG0583	DNA-binding transcription factor activity
HGD77_RS10585	COG1056	cytidyltransferase-related domain
HGD77_RS10585	COG1051	belongs to the nudix hydrolase family
HGD77_RS10595	COG0778	Nitroreductase
HGD77_RS10600	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HGD77_RS10610	COG0583	DNA-binding transcription factor activity
HGD77_RS10625	COG0047	phosphoribosylformylglycinamidine synthase activity
HGD77_RS10625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGD77_RS10645	COG2255	four-way junction helicase activity
HGD77_RS10660	COG1473	amidohydrolase
HGD77_RS10665	COG0824	Thioesterase
HGD77_RS10685	COG0823	Involved in the tonB-independent uptake of proteins
HGD77_RS10705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGD77_RS10735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGD77_RS10740	COG0628	permease
HGD77_RS10745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGD77_RS10750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGD77_RS10755	COG2267	carboxylic ester hydrolase activity
HGD77_RS10775	COG1136	(ABC) transporter
HGD77_RS10795	COG1671	Belongs to the UPF0178 family
HGD77_RS10815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_RS10855	COG1280	lysine exporter protein (LysE YggA)
HGD77_RS10860	COG1522	sequence-specific DNA binding
HGD77_RS10870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGD77_RS10885	COG0019	diaminopimelate decarboxylase activity
HGD77_RS10895	COG1113	amino acid transport
HGD77_RS10900	COG1115	amino acid carrier protein
HGD77_RS10945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HGD77_RS10950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HGD77_RS10955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGD77_RS10960	COG1716	ATPase activity
HGD77_RS10960	COG5001	Diguanylate cyclase
HGD77_RS10975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HGD77_RS10995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGD77_RS11010	COG0037	tRNA processing
HGD77_RS11015	COG0739	heme binding
HGD77_RS11015	COG1196	nuclear chromosome segregation
HGD77_RS11015	COG0741	lytic transglycosylase activity
HGD77_RS11020	COG0501	Belongs to the peptidase M48B family
HGD77_RS11030	COG2239	Acts as a magnesium transporter
HGD77_RS11055	COG1253	flavin adenine dinucleotide binding
HGD77_RS11095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGD77_RS11105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGD77_RS11135	COG0505	Belongs to the CarA family
HGD77_RS11140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGD77_RS11150	COG1309	transcriptional regulator
HGD77_RS11155	COG0251	oxidation-reduction process
HGD77_RS11180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGD77_RS11205	COG0564	pseudouridine synthase activity
HGD77_RS11215	COG0358	DNA primase activity
HGD77_RS11220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HGD77_RS11230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HGD77_RS11260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGD77_RS11265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGD77_RS11290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGD77_RS11315	COG0586	Pfam SNARE associated Golgi protein
HGD77_RS11360	COG0531	amino acid
HGD77_RS11370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HGD77_RS11375	COG1648	precorrin-2 dehydrogenase activity
HGD77_RS11375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HGD77_RS11380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGD77_RS11390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGD77_RS11400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGD77_RS11415	COG0671	phosphoesterase, PA-phosphatase related
HGD77_RS11420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_RS11435	COG0393	Putative heavy-metal-binding
HGD77_RS11440	COG0393	Putative heavy-metal-binding
HGD77_RS11470	COG4251	negative regulation of phosphorylation
HGD77_RS11470	COG3706	GGDEF domain
HGD77_RS11470	COG2203	Gaf domain
HGD77_RS11470	COG5001	Diguanylate cyclase
HGD77_RS11485	COG4681	YaeQ
HGD77_RS11490	COG0523	cobalamin synthesis protein
HGD77_RS11510	COG0583	DNA-binding transcription factor activity
HGD77_RS11525	COG1607	acyl-coa hydrolase
HGD77_RS11535	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGD77_RS11540	COG2059	Chromate
HGD77_RS11545	COG1115	amino acid carrier protein
HGD77_RS11550	COG0786	glutamate:sodium symporter activity
HGD77_RS11635	COG2832	Protein of unknown function (DUF454)
HGD77_RS11665	COG0840	transmembrane signaling receptor activity
HGD77_RS11695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_RS11740	COG0489	protein tyrosine kinase activity
HGD77_RS11760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGD77_RS11760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGD77_RS11775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGD77_RS11800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HGD77_RS11810	COG2081	HI0933 family
HGD77_RS11825	COG0668	transmembrane transport
HGD77_RS11835	COG4302	ethanolamine ammonia-lyase activity
HGD77_RS11840	COG4303	Ethanolamine ammonia lyase large subunit
HGD77_RS11865	COG0583	DNA-binding transcription factor activity
HGD77_RS11870	COG1278	Cold shock
HGD77_RS11895	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGD77_RS11900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGD77_RS11905	COG0713	ATP synthesis coupled electron transport
HGD77_RS11915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGD77_RS11930	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HGD77_RS11950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGD77_RS11960	COG2205	protein histidine kinase activity
HGD77_RS11965	COG0745	RESPONSE REGULATOR receiver
HGD77_RS11970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGD77_RS11970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGD77_RS11980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGD77_RS12015	COG4372	Transposase
HGD77_RS12040	COG2433	Pfam Transposase IS66
HGD77_RS12060	COG4372	Transposase
HGD77_RS12140	COG0351	phosphomethylpyrimidine kinase
HGD77_RS12140	COG0352	thiamine-phosphate diphosphorylase activity
HGD77_RS12140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGD77_RS12165	COG2824	Alkylphosphonate utilization operon protein PhnA
HGD77_RS12185	COG0564	pseudouridine synthase activity
HGD77_RS12230	COG2132	Multicopper oxidase
HGD77_RS12235	COG0354	folic acid binding
HGD77_RS12255	COG1902	pentaerythritol trinitrate reductase activity
HGD77_RS12290	COG2233	PERMEase
HGD77_RS12300	COG0833	amino acid
HGD77_RS12315	COG4968	Prepilin-type N-terminal cleavage methylation domain
HGD77_RS12320	COG0183	Belongs to the thiolase family
HGD77_RS12340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_RS12345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HGD77_RS12350	COG2207	Transcriptional regulator
HGD77_RS12355	COG0183	Belongs to the thiolase family
HGD77_RS12360	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGD77_RS12360	COG1024	Enoyl-CoA hydratase
HGD77_RS12380	COG1272	protein, Hemolysin III
HGD77_RS12385	COG0477	Major facilitator Superfamily
HGD77_RS12395	COG1408	metallophosphoesterase
HGD77_RS12400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGD77_RS12410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGD77_RS12425	COG3293	Transposase
HGD77_RS12455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HGD77_RS12460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGD77_RS12465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HGD77_RS12470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGD77_RS12475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HGD77_RS12480	COG0625	glutathione transferase activity
HGD77_RS12485	COG2969	positive regulation of protein catabolic process
HGD77_RS12505	COG2433	Pfam Transposase IS66
HGD77_RS12555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGD77_RS12560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HGD77_RS12570	COG0653	protein targeting
HGD77_RS12575	COG0450	alkyl hydroperoxide reductase
HGD77_RS12590	COG0285	dihydrofolate synthase activity
HGD77_RS12640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGD77_RS12650	COG1704	LemA family
HGD77_RS12665	COG1862	Preprotein translocase
HGD77_RS12675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGD77_RS12685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGD77_RS12700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGD77_RS12715	COG2084	Dehydrogenase
HGD77_RS12720	COG3622	Belongs to the hyi family
HGD77_RS12770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGD77_RS12780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGD77_RS12785	COG2003	Belongs to the UPF0758 family
HGD77_RS12790	COG3781	membrane
HGD77_RS12805	COG2350	Protein conserved in bacteria
HGD77_RS12840	COG1607	acyl-coa hydrolase
HGD77_RS12900	COG1183	phosphatidylcholine synthase activity
HGD77_RS12905	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HGD77_RS12945	COG1196	nuclear chromosome segregation
HGD77_RS12945	COG0739	heme binding
HGD77_RS12945	COG0741	lytic transglycosylase activity
HGD77_RS12950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGD77_RS12955	COG1702	phosphate starvation-inducible protein PhoH
HGD77_RS13010	COG1295	ribonuclease BN
HGD77_RS13030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGD77_RS13070	COG0557	exoribonuclease II activity
HGD77_RS13080	COG0339	signal peptide processing
HGD77_RS13085	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HGD77_RS13095	COG0697	spore germination
HGD77_RS13120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HGD77_RS13125	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS13130	COG2072	flavoprotein involved in K transport
HGD77_RS13135	COG0203	ribosomal protein L17
HGD77_RS13140	COG0202	RNA polymerase activity
HGD77_RS13145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGD77_RS13155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGD77_RS13180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGD77_RS13190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGD77_RS13195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGD77_RS13245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGD77_RS13255	COG0089	rRNA binding
HGD77_RS13260	COG0088	Forms part of the polypeptide exit tunnel
HGD77_RS13280	COG0626	cystathionine gamma-synthase activity
HGD77_RS13300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGD77_RS13300	COG1017	nitric oxide dioxygenase activity
HGD77_RS13305	COG1959	2 iron, 2 sulfur cluster binding
HGD77_RS13315	COG1301	dicarboxylic acid transport
HGD77_RS13320	COG1946	Acyl-CoA thioesterase
HGD77_RS13325	COG2937	Belongs to the GPAT DAPAT family
HGD77_RS13345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGD77_RS13350	COG1040	competence protein
HGD77_RS13355	COG0494	nUDIX hydrolase
HGD77_RS13365	COG0598	Magnesium transport protein CorA
HGD77_RS13385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HGD77_RS13390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGD77_RS13395	COG1127	ABC transporter
HGD77_RS13400	COG0513	Belongs to the DEAD box helicase family
HGD77_RS13420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGD77_RS13440	COG1960	acyl-CoA dehydrogenase activity
HGD77_RS13445	COG1278	Cold shock
HGD77_RS13465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGD77_RS13475	COG0534	Mate efflux family protein
HGD77_RS13485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGD77_RS13490	COG0254	rRNA binding
HGD77_RS13495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGD77_RS13530	COG0628	permease
HGD77_RS13540	COG1289	transmembrane transporter activity
HGD77_RS13545	COG2814	Major facilitator Superfamily
HGD77_RS13565	COG0277	FAD linked oxidase domain protein
HGD77_RS13570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGD77_RS13620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGD77_RS13625	COG5380	lipid catabolic process
HGD77_RS13630	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HGD77_RS13635	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HGD77_RS13650	COG0335	large ribosomal subunit rRNA binding
HGD77_RS13660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGD77_RS13665	COG0228	four-way junction DNA binding
HGD77_RS13685	COG0194	GDP metabolic process
HGD77_RS13690	COG1758	RNA polymerase activity
HGD77_RS13695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGD77_RS13720	COG3307	-O-antigen
HGD77_RS13750	COG1704	LemA family
HGD77_RS13755	COG0493	'glutamate synthase
HGD77_RS13760	COG0067	glutamate synthase
HGD77_RS13760	COG0069	glutamate synthase activity
HGD77_RS13760	COG0070	glutamate synthase
HGD77_RS13810	COG2226	methyltransferase
HGD77_RS13815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGD77_RS13820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGD77_RS13825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGD77_RS13845	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGD77_RS13860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGD77_RS13880	COG0488	(ABC) transporter
HGD77_RS13885	COG2873	o-acetylhomoserine
HGD77_RS13890	COG4221	oxidoreductase activity
HGD77_RS13895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HGD77_RS13910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGD77_RS13910	COG2111	Na H antiporter
HGD77_RS13915	COG1006	Multisubunit Na H antiporter MnhC subunit
HGD77_RS13920	COG0651	ATP synthesis coupled electron transport
HGD77_RS13925	COG1863	multisubunit Na H antiporter MnhE subunit
HGD77_RS13930	COG2212	antiporter activity
HGD77_RS13940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGD77_RS13950	COG0195	Participates in both transcription termination and antitermination
HGD77_RS13955	COG0779	Required for maturation of 30S ribosomal subunits
HGD77_RS14010	COG0237	dephospho-CoA kinase activity
HGD77_RS14020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGD77_RS14025	COG3123	guanosine phosphorylase activity
HGD77_RS14030	COG0497	DNA recombination
HGD77_RS14040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGD77_RS14050	COG1132	(ABC) transporter
HGD77_RS14060	COG1538	Outer membrane efflux protein
HGD77_RS14075	COG0494	nUDIX hydrolase
HGD77_RS14085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGD77_RS14090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGD77_RS14100	COG0772	Belongs to the SEDS family
HGD77_RS14125	COG4974	Belongs to the 'phage' integrase family
HGD77_RS14130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGD77_RS14140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGD77_RS14145	COG1686	Belongs to the peptidase S11 family
HGD77_RS14150	COG2197	response regulator
HGD77_RS14165	COG3409	Peptidoglycan-binding domain 1 protein
HGD77_RS14165	COG0793	Belongs to the peptidase S41A family
HGD77_RS14170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGD77_RS14175	COG0795	lipopolysaccharide-transporting ATPase activity
HGD77_RS14180	COG0795	lipopolysaccharide-transporting ATPase activity
HGD77_RS14200	COG0586	Pfam SNARE associated Golgi protein
HGD77_RS14215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGD77_RS14215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGD77_RS14225	COG0004	ammonium transporteR
HGD77_RS14230	COG0347	Belongs to the P(II) protein family
HGD77_RS14240	COG0606	chelatase, subunit chli
HGD77_RS14250	COG4372	Transposase
HGD77_RS14260	COG2963	transposase activity
HGD77_RS14285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGD77_RS14315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_RS14380	COG0606	chelatase, subunit chli
HGD77_RS14400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGD77_RS14425	COG0477	Major facilitator Superfamily
HGD77_RS14430	COG2860	membrane
HGD77_RS14440	COG1253	flavin adenine dinucleotide binding
HGD77_RS14475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGD77_RS14480	COG0477	Major facilitator Superfamily
HGD77_RS14500	COG2814	Major facilitator Superfamily
HGD77_RS14550	COG0758	DNA mediated transformation
HGD77_RS14560	COG0697	spore germination
HGD77_RS14565	COG0386	Belongs to the glutathione peroxidase family
HGD77_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_RS14600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGD77_RS14650	COG1121	(ABC) transporter
HGD77_RS14665	COG2837	iron assimilation
HGD77_RS14710	COG3501	Rhs element vgr protein
HGD77_RS14720	COG0534	Mate efflux family protein
HGD77_RS14755	COG2433	Pfam Transposase IS66
HGD77_RS14770	COG3706	GGDEF domain
HGD77_RS14775	COG3706	GGDEF domain
HGD77_RS14780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGD77_RS14780	COG0519	Catalyzes the synthesis of GMP from XMP
HGD77_RS14785	COG0586	Pfam SNARE associated Golgi protein
HGD77_RS14800	COG1192	Involved in chromosome partitioning
HGD77_RS14810	COG0271	Belongs to the BolA IbaG family
HGD77_RS14845	COG3756	Protein conserved in bacteria
HGD77_RS14875	COG3335	DDE superfamily endonuclease
HGD77_RS14895	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_RS14900	COG3138	arginine N-succinyltransferase
HGD77_RS14905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGD77_RS14910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HGD77_RS14925	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS14955	COG0494	nUDIX hydrolase
HGD77_RS14995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HGD77_RS15045	COG3540	Alkaline phosphatase
HGD77_RS15075	COG1538	Outer membrane efflux protein
HGD77_RS15135	COG0281	malic enzyme
HGD77_RS15155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HGD77_RS15170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HGD77_RS15180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGD77_RS15225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGD77_RS15235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGD77_RS15250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGD77_RS15275	COG0438	transferase activity, transferring glycosyl groups
HGD77_RS15280	COG0438	transferase activity, transferring glycosyl groups
HGD77_RS15315	COG1088	dTDP-glucose 4,6-dehydratase activity
HGD77_RS15325	COG2244	polysaccharide biosynthetic process
HGD77_RS15340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGD77_RS15350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HGD77_RS15355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGD77_RS15360	COG0438	transferase activity, transferring glycosyl groups
HGD77_RS15370	COG0438	transferase activity, transferring glycosyl groups
HGD77_RS15395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HGD77_RS15430	COG4372	Transposase
HGD77_RS15490	COG3189	MarR family transcriptional regulator
HGD77_RS15500	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HGD77_RS15505	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGD77_RS15510	COG0583	DNA-binding transcription factor activity
HGD77_RS15540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_RS15545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGD77_RS15620	COG3293	Transposase
HGD77_RS15625	COG4372	Transposase
HGD77_RS15650	COG1309	transcriptional regulator
HGD77_RS15660	COG1902	pentaerythritol trinitrate reductase activity
HGD77_RS15685	COG1979	alcohol dehydrogenase
HGD77_RS15700	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HGD77_RS15715	COG0604	alcohol dehydrogenase
HGD77_RS15715	COG3321	synthase
HGD77_RS15720	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HGD77_RS15725	COG0583	DNA-binding transcription factor activity
HGD77_RS15730	COG4221	oxidoreductase activity
HGD77_RS15855	COG0431	NADPH-dependent FMN reductase
HGD77_RS15870	COG2132	Multicopper oxidase
HGD77_RS15885	COG2205	protein histidine kinase activity
HGD77_RS15890	COG3174	membrane
HGD77_RS15895	COG2217	Heavy metal translocating P-type atpase
HGD77_RS15915	COG3293	Transposase
HGD77_RS15930	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_RS15985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGD77_RS16025	COG1764	response to oxidative stress
HGD77_RS16030	COG1846	Transcriptional regulator
HGD77_RS16035	COG3293	Transposase
HGD77_RS16040	COG0804	urea catabolic process
HGD77_RS16050	COG0831	urea catabolic process
HGD77_RS16055	COG0829	nickel cation binding
HGD77_RS16070	COG0830	nickel cation binding
HGD77_RS16095	COG3293	Transposase
HGD77_RS16105	COG1192	Involved in chromosome partitioning
HGD77_RS16145	COG2433	Pfam Transposase IS66
HGD77_RS16165	COG4774	siderophore transport
HGD77_RS16185	COG1454	alcohol dehydrogenase
HGD77_RS16210	COG4773	Receptor
HGD77_RS16230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_RS16250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGD77_RS16255	COG2267	carboxylic ester hydrolase activity
HGD77_RS16255	COG2226	methyltransferase
HGD77_RS16260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGD77_RS16260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGD77_RS16270	COG4106	trans-aconitate 2-methyltransferase activity
HGD77_RS16280	COG0642	Histidine kinase
HGD77_RS16295	COG2186	Transcriptional regulator
HGD77_RS16310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGD77_RS16310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGD77_RS16315	COG1105	Belongs to the carbohydrate kinase PfkB family
HGD77_RS16330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGD77_RS16375	COG4962	Type ii secretion system protein e
HGD77_RS16390	COG3451	type IV secretory pathway VirB4
HGD77_RS16410	COG3846	protein secretion by the type IV secretion system
HGD77_RS16415	COG3701	Conjugal transfer protein
HGD77_RS16420	COG3504	Conjugal transfer protein
HGD77_RS16435	COG2948	multi-organism process
HGD77_RS16460	COG2026	Addiction module toxin, RelE StbE family
HGD77_RS16560	COG2814	Major facilitator Superfamily
HGD77_RS16575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGD77_RS16620	COG0739	heme binding
HGD77_RS16620	COG0741	lytic transglycosylase activity
HGD77_RS16620	COG1196	nuclear chromosome segregation
HGD77_RS16700	COG3077	Addiction module antitoxin, RelB DinJ family
HGD77_RS16710	COG2801	Transposase and inactivated derivatives
HGD77_RS16720	COG2433	Pfam Transposase IS66
HGD77_RS16800	COG2801	Transposase and inactivated derivatives
HGD77_RS16810	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HGD77_RS16835	COG0659	secondary active sulfate transmembrane transporter activity
HGD77_RS16855	COG4735	regulation of single-species biofilm formation