locus-tag	class	description
AMD27_RS00010	COG0592	DNA-directed DNA polymerase activity
AMD27_RS00020	COG0187	DNA topoisomerase II activity
AMD27_RS00045	COG0596	Alpha beta hydrolase
AMD27_RS00050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMD27_RS00055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMD27_RS00060	COG0488	(ABC) transporter
AMD27_RS00070	COG0789	Transcriptional regulator
AMD27_RS00080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMD27_RS00095	COG0657	acetylesterase activity
AMD27_RS00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMD27_RS00130	COG2814	Major facilitator Superfamily
AMD27_RS00135	COG1012	belongs to the aldehyde dehydrogenase family
AMD27_RS00140	COG3738	Protein conserved in bacteria
AMD27_RS00145	COG0733	neurotransmitter:sodium symporter activity
AMD27_RS00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD27_RS00215	COG2233	PERMEase
AMD27_RS00235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_RS00260	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS00265	COG0546	phosphoglycolate phosphatase activity
AMD27_RS00270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD27_RS00285	COG1017	nitric oxide dioxygenase activity
AMD27_RS00285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMD27_RS00310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMD27_RS00330	COG3023	N-Acetylmuramoyl-L-alanine amidase
AMD27_RS00335	COG0728	peptidoglycan biosynthetic process
AMD27_RS00360	COG1596	polysaccharide export
AMD27_RS00385	COG2244	polysaccharide biosynthetic process
AMD27_RS00415	COG0110	maltose O-acetyltransferase activity
AMD27_RS00430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMD27_RS00435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMD27_RS00450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD27_RS00465	COG0271	Belongs to the BolA IbaG family
AMD27_RS00485	COG0586	Pfam SNARE associated Golgi protein
AMD27_RS00490	COG2259	Doxx family
AMD27_RS00495	COG0519	Catalyzes the synthesis of GMP from XMP
AMD27_RS00495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD27_RS00500	COG1715	Restriction endonuclease
AMD27_RS00520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_RS00555	COG0281	malic enzyme
AMD27_RS00585	COG2837	iron assimilation
AMD27_RS00600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMD27_RS00605	COG1121	(ABC) transporter
AMD27_RS00645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMD27_RS00655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMD27_RS00690	COG0386	Belongs to the glutathione peroxidase family
AMD27_RS00710	COG0758	DNA mediated transformation
AMD27_RS00715	COG1652	LysM domain
AMD27_RS00770	COG3293	Transposase
AMD27_RS00790	COG2814	Major facilitator Superfamily
AMD27_RS00795	COG2814	Major facilitator Superfamily
AMD27_RS00820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD27_RS00840	COG1253	flavin adenine dinucleotide binding
AMD27_RS00850	COG2860	membrane
AMD27_RS00855	COG0477	Major facilitator Superfamily
AMD27_RS00865	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_RS00880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMD27_RS00900	COG0606	chelatase, subunit chli
AMD27_RS00910	COG0347	Belongs to the P(II) protein family
AMD27_RS00915	COG0004	ammonium transporteR
AMD27_RS00925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD27_RS00925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD27_RS00940	COG0586	Pfam SNARE associated Golgi protein
AMD27_RS00965	COG0795	lipopolysaccharide-transporting ATPase activity
AMD27_RS00970	COG0795	lipopolysaccharide-transporting ATPase activity
AMD27_RS00975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AMD27_RS00980	COG3409	Peptidoglycan-binding domain 1 protein
AMD27_RS00980	COG0793	Belongs to the peptidase S41A family
AMD27_RS00995	COG2197	response regulator
AMD27_RS01010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMD27_RS01020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD27_RS01025	COG4974	Belongs to the 'phage' integrase family
AMD27_RS01050	COG0772	Belongs to the SEDS family
AMD27_RS01060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD27_RS01065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMD27_RS01070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMD27_RS01080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMD27_RS01110	COG2972	Histidine kinase
AMD27_RS01110	COG0745	RESPONSE REGULATOR receiver
AMD27_RS01120	COG0181	hydroxymethylbilane synthase activity
AMD27_RS01170	COG0546	phosphoglycolate phosphatase activity
AMD27_RS01200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD27_RS01210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AMD27_RS01220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMD27_RS01225	COG0081	regulation of translation
AMD27_RS01230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMD27_RS01235	COG0222	ribosome binding
AMD27_RS01240	COG0085	RNA polymerase activity
AMD27_RS01245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMD27_RS01270	COG2056	Na+-H+ antiporter family
AMD27_RS01275	COG3047	cAMP biosynthetic process
AMD27_RS01285	COG0326	Molecular chaperone. Has ATPase activity
AMD27_RS01305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMD27_RS01315	COG2199	diguanylate cyclase activity
AMD27_RS01315	COG2203	Gaf domain
AMD27_RS01335	COG0183	Belongs to the thiolase family
AMD27_RS01340	COG1024	Enoyl-CoA hydratase
AMD27_RS01340	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD27_RS01370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD27_RS01395	COG1289	transmembrane transporter activity
AMD27_RS01410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMD27_RS01420	COG0497	DNA recombination
AMD27_RS01435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD27_RS01445	COG0237	dephospho-CoA kinase activity
AMD27_RS01500	COG0779	Required for maturation of 30S ribosomal subunits
AMD27_RS01505	COG0195	Participates in both transcription termination and antitermination
AMD27_RS01515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMD27_RS01525	COG1704	LemA family
AMD27_RS01530	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AMD27_RS01545	COG3307	-O-antigen
AMD27_RS01550	COG4969	Belongs to the N-Me-Phe pilin family
AMD27_RS01555	COG3307	-O-antigen
AMD27_RS01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD27_RS01580	COG1758	RNA polymerase activity
AMD27_RS01585	COG0194	GDP metabolic process
AMD27_RS01590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMD27_RS01665	COG0228	four-way junction DNA binding
AMD27_RS01670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMD27_RS01680	COG0335	large ribosomal subunit rRNA binding
AMD27_RS01685	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_RS01690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_RS01695	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_RS01700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_RS01705	COG5380	lipid catabolic process
AMD27_RS01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMD27_RS01725	COG5006	permease, DMT superfamily
AMD27_RS01730	COG5006	permease, DMT superfamily
AMD27_RS01735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMD27_RS01740	COG0277	FAD linked oxidase domain protein
AMD27_RS01755	COG2814	Major facilitator Superfamily
AMD27_RS01765	COG1289	transmembrane transporter activity
AMD27_RS01775	COG2032	superoxide dismutase activity
AMD27_RS01780	COG0628	permease
AMD27_RS01860	COG0751	glycine-tRNA ligase activity
AMD27_RS01885	COG1983	PspC domain protein
AMD27_RS01905	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_RS01910	COG1530	ribonuclease E activity
AMD27_RS01915	COG0564	pseudouridine synthase activity
AMD27_RS01920	COG0583	DNA-binding transcription factor activity
AMD27_RS01940	COG0753	catalase activity
AMD27_RS01945	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS01960	COG0494	nUDIX hydrolase
AMD27_RS01990	COG0583	DNA-binding transcription factor activity
AMD27_RS02000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMD27_RS02015	COG0473	3-isopropylmalate dehydrogenase activity
AMD27_RS02070	COG1560	Kdo2-lipid A biosynthetic process
AMD27_RS02085	COG0831	urea catabolic process
AMD27_RS02095	COG0804	urea catabolic process
AMD27_RS02115	COG3772	lysozyme
AMD27_RS02130	COG0830	nickel cation binding
AMD27_RS02140	COG0488	(ABC) transporter
AMD27_RS02145	COG2900	Belongs to the SlyX family
AMD27_RS02170	COG1929	Belongs to the glycerate kinase type-1 family
AMD27_RS02180	COG0210	DNA helicase
AMD27_RS02200	COG4651	solute:proton antiporter activity
AMD27_RS02200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD27_RS02225	COG0788	formyltetrahydrofolate deformylase activity
AMD27_RS02330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_RS02330	COG2813	Specifically methylates the guanine in position
AMD27_RS02335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_RS02340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD27_RS02350	COG4774	siderophore transport
AMD27_RS02370	COG0740	serine-type endopeptidase activity
AMD27_RS02390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMD27_RS02390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AMD27_RS02405	COG0857	belongs to the CobB CobQ family
AMD27_RS02405	COG0280	phosphate acetyltransferase
AMD27_RS02410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMD27_RS02450	COG0793	Belongs to the peptidase S41A family
AMD27_RS02460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMD27_RS02475	COG0084	hydrolase, TatD family'
AMD27_RS02490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMD27_RS02495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD27_RS02505	COG1358	cellular component organization or biogenesis
AMD27_RS02540	COG2304	oxidoreductase activity
AMD27_RS02555	COG2814	Major facilitator Superfamily
AMD27_RS02565	COG0789	Transcriptional regulator
AMD27_RS02595	COG3622	Belongs to the hyi family
AMD27_RS02600	COG2084	Dehydrogenase
AMD27_RS02605	COG1024	Enoyl-CoA hydratase
AMD27_RS02610	COG5002	protein histidine kinase activity
AMD27_RS02610	COG2205	protein histidine kinase activity
AMD27_RS02610	COG0784	Response regulator, receiver
AMD27_RS02630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD27_RS02635	COG4221	oxidoreductase activity
AMD27_RS02640	COG3956	TIGRFAM MazG family protein
AMD27_RS02645	COG1555	photosystem II stabilization
AMD27_RS02650	COG0617	tRNA 3'-terminal CCA addition
AMD27_RS02655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMD27_RS02670	COG1660	Displays ATPase and GTPase activities
AMD27_RS02675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD27_RS02680	COG3028	Belongs to the UPF0307 family
AMD27_RS02690	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_RS02705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMD27_RS02710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMD27_RS02720	COG0625	glutathione transferase activity
AMD27_RS02730	COG1238	metal cluster binding
AMD27_RS02775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMD27_RS02780	COG0072	phenylalanine-tRNA ligase activity
AMD27_RS02785	COG0776	regulation of translation
AMD27_RS02815	COG0037	tRNA processing
AMD27_RS02830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD27_RS02830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD27_RS02865	COG1764	response to oxidative stress
AMD27_RS02870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD27_RS02915	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS02920	COG1309	transcriptional regulator
AMD27_RS02935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD27_RS02940	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS02980	COG2969	positive regulation of protein catabolic process
AMD27_RS02985	COG0625	glutathione transferase activity
AMD27_RS02990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMD27_RS02995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMD27_RS03000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMD27_RS03005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMD27_RS03010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMD27_RS03025	COG1346	cytolysis
AMD27_RS03035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMD27_RS03045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD27_RS03050	COG1408	metallophosphoesterase
AMD27_RS03055	COG0477	Major facilitator Superfamily
AMD27_RS03060	COG1272	protein, Hemolysin III
AMD27_RS03070	COG2153	protein acetylation
AMD27_RS03090	COG3293	Transposase
AMD27_RS03105	COG1280	lysine exporter protein (LysE YggA)
AMD27_RS03115	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD27_RS03115	COG1024	Enoyl-CoA hydratase
AMD27_RS03120	COG0183	Belongs to the thiolase family
AMD27_RS03135	COG2207	Transcriptional regulator
AMD27_RS03140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMD27_RS03165	COG1757	Na H antiporter
AMD27_RS03180	COG0285	dihydrofolate synthase activity
AMD27_RS03195	COG0450	alkyl hydroperoxide reductase
AMD27_RS03210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMD27_RS03215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AMD27_RS03240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AMD27_RS03240	COG2885	chlorophyll binding
AMD27_RS03245	COG2199	diguanylate cyclase activity
AMD27_RS03295	COG1126	abc transporter atp-binding protein
AMD27_RS03300	COG0765	amino acid transport
AMD27_RS03305	COG0765	amino acid transport
AMD27_RS03310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD27_RS03335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMD27_RS03340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMD27_RS03390	COG0494	nUDIX hydrolase
AMD27_RS03400	COG1214	PFAM Peptidase M22, glycoprotease
AMD27_RS03405	COG1968	undecaprenyl-diphosphatase activity
AMD27_RS03440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AMD27_RS03445	COG2076	Multidrug Resistance protein
AMD27_RS03465	COG0351	phosphomethylpyrimidine kinase
AMD27_RS03465	COG0352	thiamine-phosphate diphosphorylase activity
AMD27_RS03490	COG0251	oxidation-reduction process
AMD27_RS03495	COG1113	amino acid transport
AMD27_RS03505	COG1981	membrane
AMD27_RS03520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMD27_RS03530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMD27_RS03535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD27_RS03545	COG0456	acetyltransferase
AMD27_RS03555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AMD27_RS03560	COG0500	methyltransferase
AMD27_RS03565	COG0492	ferredoxin-NADP+ reductase activity
AMD27_RS03570	COG1674	ftsk spoiiie
AMD27_RS03580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMD27_RS03585	COG2894	cell division
AMD27_RS03590	COG0850	regulation of cytokinetic process
AMD27_RS03600	COG0204	Acyl-transferase
AMD27_RS03610	COG0210	DNA helicase
AMD27_RS03620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD27_RS03630	COG0121	glutamine amidotransferase
AMD27_RS03645	COG2914	Belongs to the UPF0125 (RnfH) family
AMD27_RS03650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD27_RS03655	COG0735	belongs to the Fur family
AMD27_RS03685	COG0420	3'-5' exonuclease activity
AMD27_RS03690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD27_RS03730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD27_RS03740	COG2050	protein possibly involved in aromatic compounds catabolism
AMD27_RS03745	COG1566	PFAM secretion protein HlyD family protein
AMD27_RS03755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMD27_RS03790	COG2852	Protein conserved in bacteria
AMD27_RS03795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AMD27_RS03815	COG3177	Filamentation induced by cAMP protein fic
AMD27_RS03890	COG2814	Major facilitator Superfamily
AMD27_RS03895	COG4264	IucA IucC family
AMD27_RS03900	COG4264	IucA IucC family
AMD27_RS03935	COG1414	Transcriptional regulator
AMD27_RS03940	COG2146	nitrite reductase [NAD(P)H] activity
AMD27_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS03970	COG2271	Major facilitator Superfamily
AMD27_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS03990	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AMD27_RS03995	COG1012	belongs to the aldehyde dehydrogenase family
AMD27_RS04000	COG0028	Belongs to the TPP enzyme family
AMD27_RS04020	COG4772	TonB-dependent receptor
AMD27_RS04055	COG3706	GGDEF domain
AMD27_RS04060	COG0242	peptide deformylase activity
AMD27_RS04065	COG2066	Belongs to the glutaminase family
AMD27_RS04075	COG2376	Dihydroxyacetone kinase
AMD27_RS04090	COG0306	phosphate transporter
AMD27_RS04110	COG4771	TonB-dependent receptor
AMD27_RS04135	COG4181	ATPase activity
AMD27_RS04140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AMD27_RS04160	COG0583	DNA-binding transcription factor activity
AMD27_RS04170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD27_RS04175	COG1773	rubredoxin
AMD27_RS04180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD27_RS04185	COG3150	esterase
AMD27_RS04200	COG0175	sulfate reduction
AMD27_RS04215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AMD27_RS04245	COG0525	valine-tRNA ligase activity
AMD27_RS04255	COG4221	oxidoreductase activity
AMD27_RS04270	COG0393	Putative heavy-metal-binding
AMD27_RS04275	COG0393	Putative heavy-metal-binding
AMD27_RS04285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD27_RS04290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_RS04310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMD27_RS04320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AMD27_RS04330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMD27_RS04335	COG1648	precorrin-2 dehydrogenase activity
AMD27_RS04335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMD27_RS04340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMD27_RS04350	COG0531	amino acid
AMD27_RS04365	COG0321	lipoyl(octanoyl) transferase activity
AMD27_RS04440	COG0586	Pfam SNARE associated Golgi protein
AMD27_RS04475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMD27_RS04505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AMD27_RS04520	COG0358	DNA primase activity
AMD27_RS04565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD27_RS04600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMD27_RS04600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD27_RS04615	COG0300	oxidoreductase activity
AMD27_RS04620	COG2072	flavoprotein involved in K transport
AMD27_RS04645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMD27_RS04650	COG1053	succinate dehydrogenase
AMD27_RS04655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMD27_RS04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD27_RS04680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMD27_RS04700	COG0742	ribosomal rna small subunit methyltransferase
AMD27_RS04705	COG0768	penicillin binding
AMD27_RS04725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMD27_RS04730	COG2878	Part of a membrane complex involved in electron transport
AMD27_RS04735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMD27_RS04745	COG3384	dioxygenase
AMD27_RS04770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMD27_RS04780	COG2217	Heavy metal translocating P-type atpase
AMD27_RS04805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMD27_RS04810	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS04840	COG0006	proline dipeptidase activity
AMD27_RS04875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD27_RS04880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD27_RS04900	COG0792	nuclease activity
AMD27_RS04930	COG1388	LysM domain
AMD27_RS04930	COG0741	lytic transglycosylase activity
AMD27_RS04930	COG1388	LysM domain
AMD27_RS04930	COG0741	lytic transglycosylase activity
AMD27_RS04940	COG4174	ABC transporter (Permease)
AMD27_RS04945	COG4239	(ABC) transporter, permease
AMD27_RS04950	COG4172	Belongs to the ABC transporter superfamily
AMD27_RS04960	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
AMD27_RS04985	COG0833	amino acid
AMD27_RS04995	COG1671	Belongs to the UPF0178 family
AMD27_RS05015	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD27_RS05020	COG1136	(ABC) transporter
AMD27_RS05025	COG3293	Transposase
AMD27_RS05070	COG2333	competence protein COMEC
AMD27_RS05070	COG0658	competence protein
AMD27_RS05090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMD27_RS05095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMD27_RS05100	COG0628	permease
AMD27_RS05140	COG3321	synthase
AMD27_RS05140	COG0604	alcohol dehydrogenase
AMD27_RS05145	COG3634	alkyl hydroperoxide reductase activity
AMD27_RS05155	COG0583	DNA-binding transcription factor activity
AMD27_RS05165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD27_RS05170	COG0826	peptidase U32
AMD27_RS05185	COG0789	Transcriptional regulator
AMD27_RS05205	COG1720	tRNA m6t6A37 methyltransferase activity
AMD27_RS05210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD27_RS05245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD27_RS05250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMD27_RS05255	COG3139	Protein of unknown function (DUF1315)
AMD27_RS05260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD27_RS05265	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS05280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMD27_RS05320	COG0415	Belongs to the DNA photolyase family
AMD27_RS05330	COG1252	NADH dehydrogenase
AMD27_RS05335	COG1686	Belongs to the peptidase S11 family
AMD27_RS05385	COG0612	Peptidase, M16
AMD27_RS05405	COG1132	(ABC) transporter
AMD27_RS05415	COG1309	transcriptional regulator
AMD27_RS05470	COG3657	addiction module killer protein
AMD27_RS05475	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD27_RS05480	COG1335	isochorismatase
AMD27_RS05485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMD27_RS05495	COG0352	thiamine-phosphate diphosphorylase activity
AMD27_RS05520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD27_RS05525	COG0697	spore germination
AMD27_RS05535	COG1022	Amp-dependent synthetase and ligase
AMD27_RS05540	COG1309	transcriptional regulator
AMD27_RS05565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AMD27_RS05570	COG0076	glutamate decarboxylase activity
AMD27_RS05580	COG0573	inorganic phosphate transmembrane transporter activity
AMD27_RS05590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMD27_RS05600	COG2814	Major facilitator Superfamily
AMD27_RS05635	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS05660	COG3829	transcription factor binding
AMD27_RS05670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD27_RS05705	COG1024	Enoyl-CoA hydratase
AMD27_RS05710	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_RS05715	COG1024	Enoyl-CoA hydratase
AMD27_RS05720	COG1024	Enoyl-CoA hydratase
AMD27_RS05720	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD27_RS05725	COG0047	phosphoribosylformylglycinamidine synthase activity
AMD27_RS05725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMD27_RS05735	COG3323	Protein of unknown function (DUF1653)
AMD27_RS05735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMD27_RS05740	COG0778	Nitroreductase
AMD27_RS05750	COG1056	cytidyltransferase-related domain
AMD27_RS05750	COG1051	belongs to the nudix hydrolase family
AMD27_RS05755	COG0583	DNA-binding transcription factor activity
AMD27_RS05765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD27_RS05775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMD27_RS05780	COG0602	queuosine metabolic process
AMD27_RS05785	COG2171	N-acyltransferase activity
AMD27_RS05795	COG0583	DNA-binding transcription factor activity
AMD27_RS05800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMD27_RS05805	COG4208	sulfate ABC transporter
AMD27_RS05810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AMD27_RS05820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD27_RS05830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMD27_RS05835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMD27_RS05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD27_RS05875	COG1027	Aspartate ammonia-lyase
AMD27_RS05880	COG0583	DNA-binding transcription factor activity
AMD27_RS05885	COG1301	dicarboxylic acid transport
AMD27_RS05910	COG0571	ribonuclease III activity
AMD27_RS05915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMD27_RS05925	COG1381	Involved in DNA repair and RecF pathway recombination
AMD27_RS05930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD27_RS05965	COG0436	Aminotransferase
AMD27_RS05980	COG3293	Transposase
AMD27_RS06005	COG1301	dicarboxylic acid transport
AMD27_RS06010	COG2391	methyltransferase activity
AMD27_RS06025	COG3634	alkyl hydroperoxide reductase activity
AMD27_RS06055	COG1643	Atp-dependent helicase
AMD27_RS06095	COG0517	IMP dehydrogenase activity
AMD27_RS06095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AMD27_RS06100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMD27_RS06110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AMD27_RS06115	COG1137	ATPase activity
AMD27_RS06125	COG1132	(ABC) transporter
AMD27_RS06160	COG4122	O-methyltransferase activity
AMD27_RS06170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMD27_RS06190	COG0583	DNA-binding transcription factor activity
AMD27_RS06200	COG1280	lysine exporter protein (LysE YggA)
AMD27_RS06215	COG1280	lysine exporter protein (LysE YggA)
AMD27_RS06295	COG3311	Transcriptional regulator
AMD27_RS06330	COG0210	DNA helicase
AMD27_RS06340	COG1570	exodeoxyribonuclease VII activity
AMD27_RS06385	COG1968	undecaprenyl-diphosphatase activity
AMD27_RS06390	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMD27_RS06395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMD27_RS06405	COG2205	protein histidine kinase activity
AMD27_RS06460	COG0436	Aminotransferase
AMD27_RS06465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD27_RS06470	COG0386	Belongs to the glutathione peroxidase family
AMD27_RS06475	COG2431	L-lysine efflux transmembrane transporter activity
AMD27_RS06490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMD27_RS06495	COG3293	Transposase
AMD27_RS06515	COG0556	nucleotide-excision repair
AMD27_RS06520	COG3040	lipid binding
AMD27_RS06555	COG0702	epimerase
AMD27_RS06560	COG1733	regulation of RNA biosynthetic process
AMD27_RS06575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMD27_RS06600	COG0305	Participates in initiation and elongation during chromosome replication
AMD27_RS06615	COG0360	Binds together with S18 to 16S ribosomal RNA
AMD27_RS06625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AMD27_RS06630	COG1845	cytochrome c oxidase, subunit III
AMD27_RS06635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMD27_RS06695	COG2308	Evidence 4 Homologs of previously reported genes of
AMD27_RS06705	COG1305	Transglutaminase-like
AMD27_RS06720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMD27_RS06725	COG3293	Transposase
AMD27_RS06730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMD27_RS06895	COG5410	chromosome segregation
AMD27_RS06900	COG3567	Phage-associated protein, HI1409 family
AMD27_RS06905	COG2369	cell adhesion
AMD27_RS07020	COG3772	lysozyme
AMD27_RS07065	COG0582	viral genome integration into host DNA
AMD27_RS07080	COG1253	flavin adenine dinucleotide binding
AMD27_RS07110	COG3135	benzoate transporter
AMD27_RS07120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMD27_RS07140	COG0183	Belongs to the thiolase family
AMD27_RS07175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMD27_RS07180	COG0824	Thioesterase
AMD27_RS07185	COG1454	alcohol dehydrogenase
AMD27_RS07190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMD27_RS07210	COG0069	glutamate synthase activity
AMD27_RS07215	COG2850	peptidyl-arginine hydroxylation
AMD27_RS07225	COG0424	maF-like protein
AMD27_RS07235	COG0126	phosphoglycerate kinase activity
AMD27_RS07245	COG0191	fructose-bisphosphate aldolase activity
AMD27_RS07250	COG0697	spore germination
AMD27_RS07275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD27_RS07280	COG0730	response to heat
AMD27_RS07285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD27_RS07305	COG0737	Belongs to the 5'-nucleotidase family
AMD27_RS07335	COG2814	Major facilitator Superfamily
AMD27_RS07340	COG0741	lytic transglycosylase activity
AMD27_RS07345	COG4589	Belongs to the CDS family
AMD27_RS07360	COG0671	phosphoesterase, PA-phosphatase related
AMD27_RS07360	COG2453	phosphatase
AMD27_RS07365	COG2267	carboxylic ester hydrolase activity
AMD27_RS07370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD27_RS07430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMD27_RS07435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AMD27_RS07450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMD27_RS07465	COG0517	IMP dehydrogenase activity
AMD27_RS07495	COG0612	Peptidase, M16
AMD27_RS07500	COG0552	protein localization to endoplasmic reticulum
AMD27_RS07525	COG4890	Cyd operon protein YbgT
AMD27_RS07530	COG1294	oxidase, subunit
AMD27_RS07545	COG1585	Membrane protein implicated in regulation of membrane protease activity
AMD27_RS07555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD27_RS07595	COG2031	fatty acid transporter
AMD27_RS07600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD27_RS07615	COG4770	biotin carboxylase activity
AMD27_RS07620	COG1024	Enoyl-CoA hydratase
AMD27_RS07625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD27_RS07630	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS07635	COG1309	transcriptional regulator
AMD27_RS07640	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_RS07650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMD27_RS07655	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_RS07665	COG0642	Histidine kinase
AMD27_RS07670	COG0745	RESPONSE REGULATOR receiver
AMD27_RS07675	COG2194	sulfuric ester hydrolase activity
AMD27_RS07720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD27_RS07730	COG2223	nitrite transmembrane transporter activity
AMD27_RS07735	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AMD27_RS07740	COG1877	trehalose-phosphatase activity
AMD27_RS07745	COG1116	anion transmembrane transporter activity
AMD27_RS07745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD27_RS07755	COG2223	nitrite transmembrane transporter activity
AMD27_RS07760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD27_RS07765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD27_RS07770	COG0243	molybdopterin cofactor binding
AMD27_RS07780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMD27_RS07790	COG0314	molybdopterin synthase activity
AMD27_RS07795	COG0315	cyclic pyranopterin monophosphate synthase activity
AMD27_RS07795	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMD27_RS07800	COG0303	'Molybdopterin
AMD27_RS07805	COG0725	ABC transporter, periplasmic molybdate-binding protein
AMD27_RS07810	COG4149	molybdate abc transporter
AMD27_RS07815	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AMD27_RS07820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_RS07825	COG0183	Belongs to the thiolase family
AMD27_RS07830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD27_RS07835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMD27_RS07840	COG3135	benzoate transporter
AMD27_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS07850	COG0633	Ferredoxin
AMD27_RS07850	COG0543	2 iron, 2 sulfur cluster binding
AMD27_RS07855	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AMD27_RS07860	COG4638	Rieske (2fe-2S)
AMD27_RS07870	COG4829	muconolactone delta-isomerase
AMD27_RS07875	COG4948	Mandelate Racemase Muconate Lactonizing
AMD27_RS07880	COG0583	DNA-binding transcription factor activity
AMD27_RS07905	COG1944	ATP diphosphatase activity
AMD27_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS07920	COG3386	PFAM SMP-30 Gluconolaconase
AMD27_RS07930	COG0583	DNA-binding transcription factor activity
AMD27_RS07945	COG0431	NADPH-dependent FMN reductase
AMD27_RS07950	COG0798	PFAM Bile acid sodium symporter
AMD27_RS07960	COG0640	Transcriptional regulator
AMD27_RS08020	COG3619	membrane
AMD27_RS08025	COG3122	Protein conserved in bacteria
AMD27_RS08030	COG0668	transmembrane transport
AMD27_RS08035	COG1132	(ABC) transporter
AMD27_RS08095	COG3300	MHYT domain
AMD27_RS08095	COG5001	Diguanylate cyclase
AMD27_RS08100	COG0596	Alpha beta hydrolase
AMD27_RS08110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AMD27_RS08115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD27_RS08160	COG0583	DNA-binding transcription factor activity
AMD27_RS08165	COG1525	nuclease
AMD27_RS08175	COG2814	Major facilitator Superfamily
AMD27_RS08200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD27_RS08205	COG0753	catalase activity
AMD27_RS08375	COG5410	chromosome segregation
AMD27_RS08410	COG1570	exodeoxyribonuclease VII activity
AMD27_RS08420	COG0494	nUDIX hydrolase
AMD27_RS08485	COG4197	protein conserved in bacteria, prophage-related
AMD27_RS08550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AMD27_RS08590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMD27_RS08595	COG0511	ligase activity, forming carbon-carbon bonds
AMD27_RS08600	COG0439	Biotin carboxylase
AMD27_RS08610	COG3706	GGDEF domain
AMD27_RS08615	COG2814	Major facilitator Superfamily
AMD27_RS08650	COG0589	response to stress
AMD27_RS08680	COG1278	Cold shock
AMD27_RS08695	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS08700	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS08705	COG0456	acetyltransferase
AMD27_RS08710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD27_RS08715	COG2207	Transcriptional regulator
AMD27_RS08720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD27_RS08725	COG0776	regulation of translation
AMD27_RS08750	COG0822	iron-sulfur transferase activity
AMD27_RS08755	COG0316	Belongs to the HesB IscA family
AMD27_RS08765	COG0443	Heat shock 70 kDa protein
AMD27_RS08785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMD27_RS08800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD27_RS08805	COG0702	epimerase
AMD27_RS08810	COG0268	Binds directly to 16S ribosomal RNA
AMD27_RS08820	COG1218	3'(2'),5'-bisphosphate nucleotidase
AMD27_RS08825	COG1011	Hydrolase
AMD27_RS08830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AMD27_RS08835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMD27_RS08840	COG2137	regulation of response to DNA damage stimulus
AMD27_RS08855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD27_RS08875	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD27_RS08890	COG0575	Belongs to the CDS family
AMD27_RS08895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMD27_RS08900	COG0233	cytoplasmic translational termination
AMD27_RS08905	COG0528	UMP kinase activity
AMD27_RS08910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD27_RS08915	COG3852	Histidine kinase
AMD27_RS08920	COG2204	response regulator
AMD27_RS08930	COG0372	Belongs to the citrate synthase family
AMD27_RS08950	COG0477	Major facilitator Superfamily
AMD27_RS08960	COG0542	response to heat
AMD27_RS08965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AMD27_RS08995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AMD27_RS09000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMD27_RS09025	COG0569	domain protein
AMD27_RS09030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMD27_RS09040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD27_RS09045	COG0583	DNA-binding transcription factor activity
AMD27_RS09070	COG0667	Aldo Keto reductase
AMD27_RS09075	COG0583	DNA-binding transcription factor activity
AMD27_RS09080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD27_RS09110	COG0772	Belongs to the SEDS family
AMD27_RS09115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD27_RS09140	COG0148	phosphopyruvate hydratase activity
AMD27_RS09165	COG0737	Belongs to the 5'-nucleotidase family
AMD27_RS09180	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD27_RS09180	COG1902	pentaerythritol trinitrate reductase activity
AMD27_RS09200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD27_RS09215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD27_RS09225	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AMD27_RS09225	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AMD27_RS09225	COG0506	proline dehydrogenase activity
AMD27_RS09230	COG0308	aminopeptidase N
AMD27_RS09250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD27_RS09290	COG4303	Ethanolamine ammonia lyase large subunit
AMD27_RS09295	COG4302	ethanolamine ammonia-lyase activity
AMD27_RS09300	COG1064	alcohol dehydrogenase
AMD27_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS09315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD27_RS09315	COG0519	Catalyzes the synthesis of GMP from XMP
AMD27_RS09320	COG1280	lysine exporter protein (LysE YggA)
AMD27_RS09360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMD27_RS09400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD27_RS09400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMD27_RS09420	COG0477	Major facilitator Superfamily
AMD27_RS09430	COG1024	Enoyl-CoA hydratase
AMD27_RS09435	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS09440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD27_RS09455	COG0583	DNA-binding transcription factor activity
AMD27_RS09460	COG0204	Acyl-transferase
AMD27_RS09505	COG1464	Belongs to the NlpA lipoprotein family
AMD27_RS09510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD27_RS09515	COG2011	ABC-type metal ion transport system permease component
AMD27_RS09520	COG0012	GTP binding
AMD27_RS09530	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AMD27_RS09565	COG0776	regulation of translation
AMD27_RS09595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMD27_RS09615	COG2165	general secretion pathway protein
AMD27_RS09620	COG2165	general secretion pathway protein
AMD27_RS09630	COG0084	hydrolase, TatD family'
AMD27_RS09650	COG1663	tetraacyldisaccharide 4'-kinase activity
AMD27_RS09655	COG1132	(ABC) transporter
AMD27_RS09665	COG0811	peptide transport
AMD27_RS09670	COG1475	DNA binding
AMD27_RS09675	COG1192	Involved in chromosome partitioning
AMD27_RS09685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMD27_RS09690	COG3178	'Phosphotransferase
AMD27_RS09700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD27_RS09705	COG1923	regulation of RNA biosynthetic process
AMD27_RS09710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD27_RS09715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMD27_RS09720	COG0802	atpase or kinase
AMD27_RS09730	COG0564	pseudouridine synthase activity
AMD27_RS09750	COG2707	UPF0756 membrane protein
AMD27_RS09755	COG0786	glutamate:sodium symporter activity
AMD27_RS09760	COG0786	glutamate:sodium symporter activity
AMD27_RS09795	COG2911	Protein conserved in bacteria
AMD27_RS09800	COG0729	surface antigen
AMD27_RS09805	COG0477	Major facilitator Superfamily
AMD27_RS09835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMD27_RS09850	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD27_RS09855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMD27_RS09870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD27_RS09890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AMD27_RS09895	COG0138	bifunctional purine biosynthesis protein purh
AMD27_RS09900	COG0151	Belongs to the GarS family
AMD27_RS09910	COG1464	Belongs to the NlpA lipoprotein family
AMD27_RS09915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD27_RS09920	COG2011	ABC-type metal ion transport system permease component
AMD27_RS10020	COG1610	YqeY-like protein
AMD27_RS10035	COG4783	chaperone-mediated protein folding
AMD27_RS10065	COG0167	dihydroorotate dehydrogenase activity
AMD27_RS10090	COG0778	Nitroreductase
AMD27_RS10100	COG0513	Belongs to the DEAD box helicase family
AMD27_RS10105	COG1278	Cold shock
AMD27_RS10120	COG2363	Small membrane protein
AMD27_RS10135	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AMD27_RS10140	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD27_RS10145	COG0625	glutathione transferase activity
AMD27_RS10155	COG0659	secondary active sulfate transmembrane transporter activity
AMD27_RS10165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMD27_RS10195	COG0540	Belongs to the ATCase OTCase family
AMD27_RS10220	COG1045	serine acetyltransferase
AMD27_RS10230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD27_RS10235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMD27_RS10240	COG1765	OsmC-like protein
AMD27_RS10250	COG0667	Aldo Keto reductase
AMD27_RS10270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMD27_RS10285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMD27_RS10290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMD27_RS10300	COG0527	aspartate kinase activity
AMD27_RS10310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMD27_RS10320	COG3038	cytochrome b561
AMD27_RS10330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMD27_RS10335	COG2252	PERMEase
AMD27_RS10345	COG2233	PERMEase
AMD27_RS10350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMD27_RS10355	COG0251	oxidation-reduction process
AMD27_RS10360	COG1335	isochorismatase
AMD27_RS10365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD27_RS10370	COG0596	Alpha beta hydrolase
AMD27_RS10375	COG0583	DNA-binding transcription factor activity
AMD27_RS10400	COG0714	Associated with various cellular activities
AMD27_RS10405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMD27_RS10410	COG2879	small protein
AMD27_RS10415	COG1966	Carbon starvation protein
AMD27_RS10420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD27_RS10440	COG0254	rRNA binding
AMD27_RS10460	COG1067	ATP-dependent peptidase activity
AMD27_RS10465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD27_RS10470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMD27_RS10500	COG1686	Belongs to the peptidase S11 family
AMD27_RS10505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMD27_RS10525	COG2132	Multicopper oxidase
AMD27_RS10545	COG2915	High frequency lysogenization protein hflD homolog
AMD27_RS10565	COG0616	signal peptide processing
AMD27_RS10590	COG0824	Thioesterase
AMD27_RS10615	COG0823	Involved in the tonB-independent uptake of proteins
AMD27_RS10635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD27_RS10655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD27_RS10690	COG1131	(ABC) transporter
AMD27_RS10695	COG0842	Transport permease protein
AMD27_RS10710	COG0772	Belongs to the SEDS family
AMD27_RS10715	COG2951	lytic endotransglycosylase activity
AMD27_RS10735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMD27_RS10740	COG0052	Belongs to the universal ribosomal protein uS2 family
AMD27_RS10765	COG2175	clavaminate synthase activity
AMD27_RS10795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMD27_RS10800	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS10805	COG0183	Belongs to the thiolase family
AMD27_RS10840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMD27_RS10845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD27_RS10850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD27_RS10860	COG0281	malic enzyme
AMD27_RS10860	COG0280	phosphate acetyltransferase
AMD27_RS10885	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AMD27_RS10900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD27_RS10905	COG1126	abc transporter atp-binding protein
AMD27_RS10915	COG0765	amino acid transport
AMD27_RS10925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD27_RS10925	COG3008	intermembrane lipid transfer
AMD27_RS10930	COG2995	paraquat-inducible protein a
AMD27_RS10935	COG2995	paraquat-inducible protein a
AMD27_RS10995	COG3210	domain, Protein
AMD27_RS11000	COG2831	hemolysin activation secretion protein
AMD27_RS11010	COG1902	pentaerythritol trinitrate reductase activity
AMD27_RS11010	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD27_RS11020	COG0697	spore germination
AMD27_RS11025	COG0583	DNA-binding transcription factor activity
AMD27_RS11035	COG5001	Diguanylate cyclase
AMD27_RS11035	COG4251	negative regulation of phosphorylation
AMD27_RS11035	COG3706	GGDEF domain
AMD27_RS11035	COG2203	Gaf domain
AMD27_RS11040	COG0418	dihydroorotase activity
AMD27_RS11045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD27_RS11110	COG1280	lysine exporter protein (LysE YggA)
AMD27_RS11115	COG1522	sequence-specific DNA binding
AMD27_RS11140	COG0019	diaminopimelate decarboxylase activity
AMD27_RS11150	COG1113	amino acid transport
AMD27_RS11155	COG1115	amino acid carrier protein
AMD27_RS11175	COG1794	racemase activity, acting on amino acids and derivatives
AMD27_RS11180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD27_RS11190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMD27_RS11225	COG0772	Belongs to the SEDS family
AMD27_RS11235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD27_RS11240	COG3161	chorismate lyase activity
AMD27_RS11265	COG0512	Glutamine amidotransferase of anthranilate synthase
AMD27_RS11270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD27_RS11285	COG0302	gtp cyclohydrolase
AMD27_RS11320	COG3739	integral membrane protein
AMD27_RS11335	COG1741	Belongs to the pirin family
AMD27_RS11350	COG3293	Transposase
AMD27_RS11355	COG0300	oxidoreductase activity
AMD27_RS11365	COG0583	DNA-binding transcription factor activity
AMD27_RS11415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD27_RS11420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AMD27_RS11435	COG0741	lytic transglycosylase activity
AMD27_RS11435	COG0739	heme binding
AMD27_RS11435	COG1196	nuclear chromosome segregation
AMD27_RS11440	COG0501	Belongs to the peptidase M48B family
AMD27_RS11460	COG0584	glycerophosphoryl diester phosphodiesterase
AMD27_RS11500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMD27_RS11505	COG1597	lipid kinase activity
AMD27_RS11515	COG0477	Major facilitator Superfamily
AMD27_RS11530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMD27_RS11570	COG2304	oxidoreductase activity
AMD27_RS11575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMD27_RS11580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMD27_RS11600	COG0505	Belongs to the CarA family
AMD27_RS11605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMD27_RS11620	COG0110	maltose O-acetyltransferase activity
AMD27_RS11640	COG0589	response to stress
AMD27_RS11665	COG2321	neutral zinc metallopeptidase
AMD27_RS11670	COG2354	Protein conserved in bacteria
AMD27_RS11685	COG2268	Band 7 protein
AMD27_RS11715	COG1253	flavin adenine dinucleotide binding
AMD27_RS11720	COG2851	Citrate transporter
AMD27_RS11745	COG2323	membrane
AMD27_RS11760	COG0004	ammonium transporteR
AMD27_RS11780	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD27_RS11795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD27_RS11800	COG0142	geranyltranstransferase activity
AMD27_RS11810	COG2828	Protein conserved in bacteria
AMD27_RS11815	COG1113	amino acid transport
AMD27_RS11840	COG0560	Phosphoserine phosphatase
AMD27_RS11850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD27_RS11860	COG0424	maF-like protein
AMD27_RS11870	COG1792	Involved in formation and maintenance of cell shape
AMD27_RS11875	COG1077	Cell shape determining protein MreB Mrl
AMD27_RS11880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMD27_RS11890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMD27_RS11915	COG0583	DNA-binding transcription factor activity
AMD27_RS11930	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AMD27_RS11945	COG1215	transferase activity, transferring glycosyl groups
AMD27_RS11950	COG0726	polysaccharide deacetylase
AMD27_RS11950	COG1649	PFAM Uncharacterised BCR, COG1649
AMD27_RS11960	COG4681	YaeQ
AMD27_RS11965	COG0523	cobalamin synthesis protein
AMD27_RS11975	COG1607	acyl-coa hydrolase
AMD27_RS11980	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD27_RS11985	COG0786	glutamate:sodium symporter activity
AMD27_RS12005	COG2814	Major facilitator Superfamily
AMD27_RS12010	COG1289	transmembrane transporter activity
AMD27_RS12015	COG1289	transmembrane transporter activity
AMD27_RS12025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD27_RS12080	COG1376	ErfK ybiS ycfS ynhG family protein
AMD27_RS12085	COG2832	Protein of unknown function (DUF454)
AMD27_RS12115	COG0840	transmembrane signaling receptor activity
AMD27_RS12140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_RS12185	COG0489	protein tyrosine kinase activity
AMD27_RS12205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD27_RS12205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD27_RS12255	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AMD27_RS12260	COG2081	HI0933 family
AMD27_RS12270	COG0668	transmembrane transport
AMD27_RS12290	COG0583	DNA-binding transcription factor activity
AMD27_RS12305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMD27_RS12315	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_RS12320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD27_RS12325	COG0713	ATP synthesis coupled electron transport
AMD27_RS12335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_RS12350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMD27_RS12360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_RS12360	COG0649	NAD binding
AMD27_RS12370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_RS12380	COG2205	protein histidine kinase activity
AMD27_RS12385	COG0745	RESPONSE REGULATOR receiver
AMD27_RS12390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD27_RS12390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMD27_RS12395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD27_RS12415	COG2814	Major facilitator Superfamily
AMD27_RS12435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMD27_RS12440	COG1309	transcriptional regulator
AMD27_RS12460	COG1652	LysM domain
AMD27_RS12470	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS12490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMD27_RS12495	COG1399	metal-binding, possibly nucleic acid-binding protein
AMD27_RS12500	COG3101	peptidyl-lysine hydroxylation
AMD27_RS12505	COG0009	L-threonylcarbamoyladenylate synthase
AMD27_RS12510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMD27_RS12515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMD27_RS12530	COG4106	trans-aconitate 2-methyltransferase activity
AMD27_RS12545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_RS12545	COG0596	Alpha beta hydrolase
AMD27_RS12545	COG2226	methyltransferase
AMD27_RS12555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD27_RS12560	COG2193	ferroxidase activity
AMD27_RS12565	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AMD27_RS12570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD27_RS12575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMD27_RS12580	COG3115	cell septum assembly
AMD27_RS12585	COG1196	nuclear chromosome segregation
AMD27_RS12595	COG0730	response to heat
AMD27_RS12620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMD27_RS12625	COG4137	Cytochrome C assembly protein
AMD27_RS12665	COG0494	nUDIX hydrolase
AMD27_RS12685	COG2824	Alkylphosphonate utilization operon protein PhnA
AMD27_RS12695	COG0564	pseudouridine synthase activity
AMD27_RS12725	COG0354	folic acid binding
AMD27_RS12750	COG1902	pentaerythritol trinitrate reductase activity
AMD27_RS12760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD27_RS12770	COG1217	gtp-binding protein TYPA
AMD27_RS12775	COG2233	PERMEase
AMD27_RS12785	COG0833	amino acid
AMD27_RS12805	COG0183	Belongs to the thiolase family
AMD27_RS12845	COG4206	TonB-dependent receptor
AMD27_RS12850	COG2096	Adenosyltransferase
AMD27_RS12870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMD27_RS12890	COG1113	amino acid transport
AMD27_RS12895	COG0745	RESPONSE REGULATOR receiver
AMD27_RS12900	COG2205	protein histidine kinase activity
AMD27_RS12910	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS12915	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS12925	COG3223	Belongs to the PsiE family
AMD27_RS12960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMD27_RS12975	COG0438	transferase activity, transferring glycosyl groups
AMD27_RS12975	COG4641	Protein conserved in bacteria
AMD27_RS13000	COG0438	transferase activity, transferring glycosyl groups
AMD27_RS13010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMD27_RS13030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMD27_RS13035	COG2205	protein histidine kinase activity
AMD27_RS13035	COG0784	Response regulator, receiver
AMD27_RS13035	COG5002	protein histidine kinase activity
AMD27_RS13045	COG1764	response to oxidative stress
AMD27_RS13050	COG1846	Transcriptional regulator
AMD27_RS13080	COG4695	Portal protein
AMD27_RS13290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMD27_RS13315	COG1862	Preprotein translocase
AMD27_RS13325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMD27_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_RS13400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD27_RS13410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD27_RS13415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD27_RS13435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD27_RS13455	COG1426	Protein conserved in bacteria
AMD27_RS13515	COG0440	acetolactate synthase activity
AMD27_RS13520	COG0028	Belongs to the TPP enzyme family
AMD27_RS13545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_RS13550	COG1136	(ABC) transporter
AMD27_RS13550	COG0577	efflux transmembrane transporter activity
AMD27_RS13555	COG1538	Outer membrane efflux protein
AMD27_RS13590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMD27_RS13595	COG1162	GTPase activity
AMD27_RS13620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMD27_RS13625	COG2003	Belongs to the UPF0758 family
AMD27_RS13630	COG3781	membrane
AMD27_RS13635	COG0613	PHP domain protein
AMD27_RS13645	COG2350	Protein conserved in bacteria
AMD27_RS13680	COG1607	acyl-coa hydrolase
AMD27_RS13740	COG1183	phosphatidylcholine synthase activity
AMD27_RS13745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AMD27_RS13780	COG0741	lytic transglycosylase activity
AMD27_RS13780	COG0739	heme binding
AMD27_RS13780	COG1196	nuclear chromosome segregation
AMD27_RS13790	COG1702	phosphate starvation-inducible protein PhoH
AMD27_RS13795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMD27_RS13800	COG0668	transmembrane transport
AMD27_RS13840	COG1295	ribonuclease BN
AMD27_RS13845	COG0697	spore germination
AMD27_RS13850	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMD27_RS13895	COG0339	signal peptide processing
AMD27_RS13900	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AMD27_RS13930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AMD27_RS13935	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS13940	COG2072	flavoprotein involved in K transport
AMD27_RS13945	COG0203	ribosomal protein L17
AMD27_RS13950	COG0202	RNA polymerase activity
AMD27_RS13955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMD27_RS13990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMD27_RS14005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMD27_RS14025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMD27_RS14055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMD27_RS14070	COG0088	Forms part of the polypeptide exit tunnel
AMD27_RS14075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMD27_RS14080	COG0051	transcription antitermination factor activity, RNA binding
AMD27_RS14085	COG0519	Catalyzes the synthesis of GMP from XMP
AMD27_RS14085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD27_RS14090	COG0626	cystathionine gamma-synthase activity
AMD27_RS14095	COG0433	COG0433 Predicted ATPase
AMD27_RS14100	COG1017	nitric oxide dioxygenase activity
AMD27_RS14100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMD27_RS14105	COG1959	2 iron, 2 sulfur cluster binding
AMD27_RS14125	COG1301	dicarboxylic acid transport
AMD27_RS14130	COG1946	Acyl-CoA thioesterase
AMD27_RS14135	COG2937	Belongs to the GPAT DAPAT family
AMD27_RS14145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMD27_RS14150	COG1040	competence protein
AMD27_RS14165	COG0598	Magnesium transport protein CorA
AMD27_RS14180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD27_RS14185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD27_RS14190	COG1127	ABC transporter
AMD27_RS14195	COG0513	Belongs to the DEAD box helicase family
AMD27_RS14215	COG0408	coproporphyrinogen oxidase activity
AMD27_RS14235	COG1960	acyl-CoA dehydrogenase activity
AMD27_RS14250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMD27_RS14260	COG0534	Mate efflux family protein
AMD27_RS14285	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMD27_RS14315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD27_RS14325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMD27_RS14340	COG0493	'glutamate synthase
AMD27_RS14350	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AMD27_RS14365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD27_RS14380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMD27_RS14390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AMD27_RS14390	COG0644	oxidoreductase
AMD27_RS14410	COG0425	Belongs to the sulfur carrier protein TusA family
AMD27_RS14415	COG4535	Mg2 and Co2 transporter CorC
AMD27_RS14420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AMD27_RS14440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMD27_RS14450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMD27_RS14460	COG0789	Transcriptional regulator
AMD27_RS14475	COG0598	Magnesium transport protein CorA
AMD27_RS14480	COG1185	polyribonucleotide nucleotidyltransferase activity
AMD27_RS14495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD27_RS14500	COG1074	ATP-dependent DNA helicase activity
AMD27_RS14505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AMD27_RS14535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD27_RS14545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMD27_RS14560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD27_RS14560	COG2111	Na H antiporter
AMD27_RS14565	COG1006	Multisubunit Na H antiporter MnhC subunit
AMD27_RS14570	COG0651	ATP synthesis coupled electron transport
AMD27_RS14575	COG1863	multisubunit Na H antiporter MnhE subunit
AMD27_RS14580	COG2212	antiporter activity
AMD27_RS14585	COG1320	monovalent cation:proton antiporter activity
AMD27_RS14595	COG0493	'glutamate synthase
AMD27_RS14600	COG0069	glutamate synthase activity
AMD27_RS14600	COG0067	glutamate synthase
AMD27_RS14600	COG0070	glutamate synthase
AMD27_RS14615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMD27_RS14650	COG2226	methyltransferase
AMD27_RS14655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD27_RS14660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD27_RS14665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMD27_RS14680	COG0275	rRNA processing
AMD27_RS14685	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD27_RS14700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD27_RS14720	COG0488	(ABC) transporter
AMD27_RS14725	COG2873	o-acetylhomoserine
AMD27_RS14730	COG4221	oxidoreductase activity
AMD27_RS14745	COG2183	response to ionizing radiation
AMD27_RS14760	COG0427	acetyl-CoA hydrolase
AMD27_RS14795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMD27_RS14835	COG1278	Cold shock
AMD27_RS14840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AMD27_RS14875	COG3158	transport of potassium into the cell
AMD27_RS14885	COG0582	viral genome integration into host DNA
AMD27_RS14925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AMD27_RS14930	COG0583	DNA-binding transcription factor activity
AMD27_RS14940	COG0629	single-stranded DNA binding
AMD27_RS14945	COG2814	Major facilitator Superfamily
AMD27_RS14955	COG0351	phosphomethylpyrimidine kinase
AMD27_RS14955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AMD27_RS14955	COG0352	thiamine-phosphate diphosphorylase activity
AMD27_RS14970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMD27_RS14990	COG2814	Major facilitator Superfamily
AMD27_RS15045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD27_RS15050	COG3162	membrane
AMD27_RS15055	COG0784	Response regulator, receiver
AMD27_RS15055	COG2205	protein histidine kinase activity
AMD27_RS15070	COG0431	NADPH-dependent FMN reductase
AMD27_RS15080	COG0307	riboflavin synthase, alpha
AMD27_RS15085	COG2223	nitrite transmembrane transporter activity
AMD27_RS15190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD27_RS15195	COG0668	transmembrane transport
AMD27_RS15200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD27_RS15205	COG1519	Transferase
AMD27_RS15210	COG1902	pentaerythritol trinitrate reductase activity
AMD27_RS15245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMD27_RS15270	COG2119	membrane
AMD27_RS15310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMD27_RS15320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD27_RS15330	COG0189	ligase activity
AMD27_RS15340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMD27_RS15345	COG0708	Exodeoxyribonuclease III
AMD27_RS15365	COG2199	diguanylate cyclase activity
AMD27_RS15365	COG2203	Gaf domain
AMD27_RS15395	COG1247	-acetyltransferase
AMD27_RS15440	COG3150	esterase
AMD27_RS15455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AMD27_RS15460	COG2918	glutathione biosynthetic process
AMD27_RS15475	COG2733	membrane
AMD27_RS15520	COG0436	Aminotransferase
AMD27_RS15525	COG0534	Mate efflux family protein
AMD27_RS15595	COG3830	Belongs to the UPF0237 family
AMD27_RS15595	COG0560	Phosphoserine phosphatase
AMD27_RS15620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMD27_RS15625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AMD27_RS15635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD27_RS15730	COG0385	Bile acid
AMD27_RS15735	COG1335	isochorismatase
AMD27_RS15740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD27_RS15750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMD27_RS15755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMD27_RS15760	COG2133	pyrroloquinoline quinone binding
AMD27_RS15765	COG2983	Belongs to the UPF0260 family
AMD27_RS15795	COG2818	Glycosylase
AMD27_RS15810	COG0583	DNA-binding transcription factor activity
AMD27_RS15815	COG2814	Major facilitator Superfamily
AMD27_RS15840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AMD27_RS15840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMD27_RS15845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD27_RS15850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD27_RS15855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD27_RS15860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD27_RS15865	COG1116	anion transmembrane transporter activity
AMD27_RS15870	COG1309	transcriptional regulator
AMD27_RS15880	COG0196	riboflavin kinase activity
AMD27_RS15885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMD27_RS15890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMD27_RS15895	COG1047	Peptidyl-prolyl cis-trans
AMD27_RS16045	COG2951	lytic endotransglycosylase activity
AMD27_RS16050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AMD27_RS16065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD27_RS16105	COG0861	Integral membrane protein TerC family
AMD27_RS16120	COG0402	S-adenosylhomocysteine deaminase activity
AMD27_RS16140	COG2814	Major facilitator Superfamily
AMD27_RS16160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMD27_RS16165	COG0594	ribonuclease P activity
AMD27_RS16320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMD27_RS16600	COG2233	PERMEase
AMD27_RS17025	COG2837	iron assimilation
AMD27_RS17165	COG0758	DNA mediated transformation
AMD27_RS17170	COG0758	DNA mediated transformation
AMD27_RS17440	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_RS17530	COG0795	lipopolysaccharide-transporting ATPase activity
AMD27_RS17620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMD27_RS17645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMD27_RS17660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction