locus-tag	class	description
O1449_RS00010	COG0592	DNA-directed DNA polymerase activity
O1449_RS00020	COG0187	DNA topoisomerase II activity
O1449_RS00025	COG0586	Pfam SNARE associated Golgi protein
O1449_RS00030	COG0488	(ABC) transporter
O1449_RS00075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O1449_RS00080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O1449_RS00125	COG1047	Peptidyl-prolyl cis-trans
O1449_RS00135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O1449_RS00140	COG0196	riboflavin kinase activity
O1449_RS00150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O1449_RS00165	COG1309	transcriptional regulator
O1449_RS00170	COG1116	anion transmembrane transporter activity
O1449_RS00175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1449_RS00180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1449_RS00185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1449_RS00190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O1449_RS00190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O1449_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
O1449_RS00205	COG0546	phosphoglycolate phosphatase activity
O1449_RS00255	COG3023	N-Acetylmuramoyl-L-alanine amidase
O1449_RS00290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O1449_RS00335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1449_RS00345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O1449_RS00355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1449_RS00370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O1449_RS00375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1449_RS00380	COG1448	Aminotransferase
O1449_RS00385	COG1802	Transcriptional regulator
O1449_RS00435	COG0564	pseudouridine synthase activity
O1449_RS00470	COG0251	oxidation-reduction process
O1449_RS00475	COG1113	amino acid transport
O1449_RS00490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1449_RS00500	COG3550	peptidyl-serine autophosphorylation
O1449_RS00520	COG0271	Belongs to the BolA IbaG family
O1449_RS00530	COG1192	Involved in chromosome partitioning
O1449_RS00545	COG0586	Pfam SNARE associated Golgi protein
O1449_RS00550	COG2259	Doxx family
O1449_RS00555	COG3111	PFAM Bacterial OB fold (BOF) protein
O1449_RS00560	COG4399	Belongs to the UPF0754 family
O1449_RS00565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O1449_RS00565	COG0519	Catalyzes the synthesis of GMP from XMP
O1449_RS00570	COG1715	Restriction endonuclease
O1449_RS00580	COG0735	belongs to the Fur family
O1449_RS00620	COG2837	iron assimilation
O1449_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1449_RS00630	COG1121	(ABC) transporter
O1449_RS00670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O1449_RS00680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O1449_RS00715	COG0386	Belongs to the glutathione peroxidase family
O1449_RS00735	COG0758	DNA mediated transformation
O1449_RS00740	COG1652	LysM domain
O1449_RS00765	COG2205	protein histidine kinase activity
O1449_RS00765	COG0784	Response regulator, receiver
O1449_RS00770	COG3162	membrane
O1449_RS00775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1449_RS00795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1449_RS00830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1449_RS00845	COG2814	Major facilitator Superfamily
O1449_RS00875	COG4452	Inner membrane protein CreD
O1449_RS00880	COG2205	protein histidine kinase activity
O1449_RS00890	COG0745	RESPONSE REGULATOR receiver
O1449_RS00895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O1449_RS00905	COG2814	Major facilitator Superfamily
O1449_RS00925	COG1253	flavin adenine dinucleotide binding
O1449_RS00935	COG2860	membrane
O1449_RS00950	COG0318	PFAM AMP-dependent synthetase and ligase
O1449_RS00965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O1449_RS01000	COG0347	Belongs to the P(II) protein family
O1449_RS01005	COG0004	ammonium transporteR
O1449_RS01015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1449_RS01015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1449_RS01050	COG0795	lipopolysaccharide-transporting ATPase activity
O1449_RS01055	COG0795	lipopolysaccharide-transporting ATPase activity
O1449_RS01065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O1449_RS01070	COG0793	Belongs to the peptidase S41A family
O1449_RS01085	COG2197	response regulator
O1449_RS01100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O1449_RS01110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O1449_RS01115	COG4974	Belongs to the 'phage' integrase family
O1449_RS01145	COG0772	Belongs to the SEDS family
O1449_RS01150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1449_RS01155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O1449_RS01160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O1449_RS01190	COG3275	phosphorelay sensor kinase activity
O1449_RS01200	COG0181	hydroxymethylbilane synthase activity
O1449_RS01245	COG1716	ATPase activity
O1449_RS01280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O1449_RS01300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O1449_RS01310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O1449_RS01315	COG0222	ribosome binding
O1449_RS01350	COG2056	Na+-H+ antiporter family
O1449_RS01355	COG3047	cAMP biosynthetic process
O1449_RS01365	COG0326	Molecular chaperone. Has ATPase activity
O1449_RS01390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1449_RS01430	COG3706	GGDEF domain
O1449_RS01455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O1449_RS01485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O1449_RS01495	COG0497	DNA recombination
O1449_RS01505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1449_RS01515	COG0237	dephospho-CoA kinase activity
O1449_RS01565	COG0195	Participates in both transcription termination and antitermination
O1449_RS01575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O1449_RS01580	COG1320	monovalent cation:proton antiporter activity
O1449_RS01585	COG2212	antiporter activity
O1449_RS01590	COG1863	multisubunit Na H antiporter MnhE subunit
O1449_RS01595	COG0651	ATP synthesis coupled electron transport
O1449_RS01600	COG1006	Multisubunit Na H antiporter MnhC subunit
O1449_RS01605	COG2111	Na H antiporter
O1449_RS01605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1449_RS01610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O1449_RS01620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O1449_RS01640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O1449_RS01650	COG2226	methyltransferase
O1449_RS01670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O1449_RS01675	COG1074	ATP-dependent DNA helicase activity
O1449_RS01680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O1449_RS01685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O1449_RS01690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O1449_RS01700	COG1301	dicarboxylic acid transport
O1449_RS01705	COG0598	Magnesium transport protein CorA
O1449_RS01710	COG0789	Transcriptional regulator
O1449_RS01725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O1449_RS01735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O1449_RS01765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O1449_RS01770	COG4535	Mg2 and Co2 transporter CorC
O1449_RS01775	COG0425	Belongs to the sulfur carrier protein TusA family
O1449_RS01785	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
O1449_RS01785	COG0644	oxidoreductase
O1449_RS01795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O1449_RS01810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1449_RS01815	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
O1449_RS01825	COG0493	'glutamate synthase
O1449_RS01825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
O1449_RS01835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1449_RS01865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O1449_RS01875	COG0534	Mate efflux family protein
O1449_RS01885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O1449_RS01900	COG0318	PFAM AMP-dependent synthetase and ligase
O1449_RS01905	COG1530	ribonuclease E activity
O1449_RS01920	COG0546	phosphoglycolate phosphatase activity
O1449_RS01930	COG0625	glutathione transferase activity
O1449_RS01935	COG0583	DNA-binding transcription factor activity
O1449_RS01950	COG3011	Protein conserved in bacteria
O1449_RS01955	COG0753	catalase activity
O1449_RS01970	COG0494	nUDIX hydrolase
O1449_RS02005	COG0583	DNA-binding transcription factor activity
O1449_RS02015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O1449_RS02030	COG0473	3-isopropylmalate dehydrogenase activity
O1449_RS02080	COG1560	Kdo2-lipid A biosynthetic process
O1449_RS02090	COG0488	(ABC) transporter
O1449_RS02095	COG2900	Belongs to the SlyX family
O1449_RS02120	COG0210	DNA helicase
O1449_RS02160	COG1538	Outer membrane efflux protein
O1449_RS02165	COG1136	(ABC) transporter
O1449_RS02165	COG0577	efflux transmembrane transporter activity
O1449_RS02170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1449_RS02175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O1449_RS02205	COG0028	Belongs to the TPP enzyme family
O1449_RS02225	COG3243	poly(R)-hydroxyalkanoic acid synthase
O1449_RS02235	COG0640	Transcriptional regulator
O1449_RS02240	COG0798	PFAM Bile acid sodium symporter
O1449_RS02250	COG4774	siderophore transport
O1449_RS02260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O1449_RS02270	COG0726	polysaccharide deacetylase
O1449_RS02275	COG0084	hydrolase, TatD family'
O1449_RS02290	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O1449_RS02305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1449_RS02325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1449_RS02340	COG3220	belongs to the UPF0276 family
O1449_RS02350	COG1595	DNA-templated transcription, initiation
O1449_RS02360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O1449_RS02360	COG4651	solute:proton antiporter activity
O1449_RS02385	COG0788	formyltetrahydrofolate deformylase activity
O1449_RS02420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O1449_RS02425	COG3878	Protein conserved in bacteria
O1449_RS02450	COG4773	Receptor
O1449_RS02465	COG1702	phosphate starvation-inducible protein PhoH
O1449_RS02475	COG0741	lytic transglycosylase activity
O1449_RS02475	COG0739	heme binding
O1449_RS02475	COG1196	nuclear chromosome segregation
O1449_RS02505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O1449_RS02510	COG1183	phosphatidylcholine synthase activity
O1449_RS02565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1449_RS02570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O1449_RS02580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O1449_RS02640	COG1214	PFAM Peptidase M22, glycoprotease
O1449_RS02645	COG1968	undecaprenyl-diphosphatase activity
O1449_RS02675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O1449_RS02685	COG2132	Multicopper oxidase
O1449_RS02710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O1449_RS02715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O1449_RS02720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O1449_RS02770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O1449_RS02775	COG1063	alcohol dehydrogenase
O1449_RS02790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1449_RS02810	COG0745	RESPONSE REGULATOR receiver
O1449_RS02815	COG2205	protein histidine kinase activity
O1449_RS02830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1449_RS02840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1449_RS02840	COG0649	NAD binding
O1449_RS02850	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
O1449_RS02865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1449_RS02880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1449_RS02885	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1449_RS02910	COG0583	DNA-binding transcription factor activity
O1449_RS02930	COG0668	transmembrane transport
O1449_RS02940	COG2081	HI0933 family
O1449_RS02950	COG2515	1-aminocyclopropane-1-carboxylate deaminase
O1449_RS02960	COG2226	methyltransferase
O1449_RS02965	COG4716	Myosin-crossreactive antigen
O1449_RS02975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1449_RS02985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1449_RS02985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1449_RS03010	COG0489	protein tyrosine kinase activity
O1449_RS03065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O1449_RS03085	COG0730	response to heat
O1449_RS03105	COG1196	nuclear chromosome segregation
O1449_RS03115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O1449_RS03135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O1449_RS03140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O1449_RS03140	COG0596	Alpha beta hydrolase
O1449_RS03140	COG2226	methyltransferase
O1449_RS03155	COG4106	trans-aconitate 2-methyltransferase activity
O1449_RS03195	COG4166	transmembrane transport
O1449_RS03200	COG0747	negative chemotaxis
O1449_RS03205	COG0339	signal peptide processing
O1449_RS03225	COG1187	pseudouridine synthase activity
O1449_RS03230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O1449_RS03235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O1449_RS03250	COG0009	L-threonylcarbamoyladenylate synthase
O1449_RS03255	COG3101	peptidyl-lysine hydroxylation
O1449_RS03260	COG1399	metal-binding, possibly nucleic acid-binding protein
O1449_RS03265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O1449_RS03285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1449_RS03295	COG1309	transcriptional regulator
O1449_RS03300	COG0625	glutathione transferase activity
O1449_RS03310	COG0352	thiamine-phosphate diphosphorylase activity
O1449_RS03310	COG0351	phosphomethylpyrimidine kinase
O1449_RS03310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O1449_RS03320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1449_RS03340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O1449_RS03370	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O1449_RS03385	COG0358	DNA primase activity
O1449_RS03395	COG0564	pseudouridine synthase activity
O1449_RS03400	COG1496	oxidoreductase activity
O1449_RS03460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O1449_RS03470	COG0732	type I restriction modification DNA specificity domain
O1449_RS03480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
O1449_RS03490	COG0582	viral genome integration into host DNA
O1449_RS03500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O1449_RS03525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1449_RS03525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O1449_RS03540	COG1981	membrane
O1449_RS03565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O1449_RS03570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O1449_RS03585	COG0456	acetyltransferase
O1449_RS03595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O1449_RS03600	COG0492	ferredoxin-NADP+ reductase activity
O1449_RS03605	COG1674	ftsk spoiiie
O1449_RS03610	COG1280	lysine exporter protein (LysE YggA)
O1449_RS03620	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O1449_RS03625	COG2894	cell division
O1449_RS03630	COG0850	regulation of cytokinetic process
O1449_RS03640	COG0204	Acyl-transferase
O1449_RS03645	COG2885	chlorophyll binding
O1449_RS03650	COG0210	DNA helicase
O1449_RS03655	COG0756	dUTP diphosphatase activity
O1449_RS03675	COG0121	glutamine amidotransferase
O1449_RS03695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1449_RS03700	COG0735	belongs to the Fur family
O1449_RS03730	COG0420	3'-5' exonuclease activity
O1449_RS03735	COG1024	Enoyl-CoA hydratase
O1449_RS03755	COG1090	epimerase
O1449_RS03760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1449_RS03770	COG2050	protein possibly involved in aromatic compounds catabolism
O1449_RS03775	COG1566	PFAM secretion protein HlyD family protein
O1449_RS03780	COG2814	Major facilitator Superfamily
O1449_RS03800	COG1607	acyl-coa hydrolase
O1449_RS03810	COG0523	cobalamin synthesis protein
O1449_RS03815	COG4681	YaeQ
O1449_RS03830	COG1649	PFAM Uncharacterised BCR, COG1649
O1449_RS03830	COG0726	polysaccharide deacetylase
O1449_RS03835	COG1215	transferase activity, transferring glycosyl groups
O1449_RS03880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O1449_RS03925	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
O1449_RS03930	COG1597	lipid kinase activity
O1449_RS04015	COG0154	amidase activity
O1449_RS04030	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
O1449_RS04040	COG0732	type I restriction modification DNA specificity domain
O1449_RS04055	COG0582	viral genome integration into host DNA
O1449_RS04085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O1449_RS04120	COG0288	reversible hydration of carbon dioxide
O1449_RS04130	COG4181	ATPase activity
O1449_RS04135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
O1449_RS04155	COG2070	2-Nitropropane dioxygenase
O1449_RS04170	COG0415	Belongs to the DNA photolyase family
O1449_RS04180	COG1252	NADH dehydrogenase
O1449_RS04185	COG1686	Belongs to the peptidase S11 family
O1449_RS04210	COG1187	pseudouridine synthase activity
O1449_RS04225	COG0612	Peptidase, M16
O1449_RS04240	COG3025	triphosphatase activity
O1449_RS04260	COG1203	CRISPR-associated helicase, Cas3
O1449_RS04290	COG0352	thiamine-phosphate diphosphorylase activity
O1449_RS04305	COG0564	pseudouridine synthase activity
O1449_RS04315	COG0783	Belongs to the Dps family
O1449_RS04325	COG1309	transcriptional regulator
O1449_RS04345	COG1309	transcriptional regulator
O1449_RS04350	COG1943	Transposase
O1449_RS04360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1449_RS04365	COG0076	glutamate decarboxylase activity
O1449_RS04375	COG0573	inorganic phosphate transmembrane transporter activity
O1449_RS04385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1449_RS04390	COG0616	signal peptide processing
O1449_RS04410	COG1846	Transcriptional regulator
O1449_RS04410	COG0456	acetyltransferase
O1449_RS04420	COG0742	ribosomal rna small subunit methyltransferase
O1449_RS04425	COG0768	penicillin binding
O1449_RS04455	COG0714	Associated with various cellular activities
O1449_RS04460	COG2425	protein containing a von Willebrand factor type A (vWA) domain
O1449_RS04465	COG3552	Protein containing von Willebrand factor type A (VWA) domain
O1449_RS04475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O1449_RS04480	COG2878	Part of a membrane complex involved in electron transport
O1449_RS04495	COG3384	dioxygenase
O1449_RS04510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O1449_RS04525	COG2217	Heavy metal translocating P-type atpase
O1449_RS04555	COG3079	Belongs to the UPF0149 family
O1449_RS04560	COG0006	proline dipeptidase activity
O1449_RS04570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1449_RS04575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1449_RS04585	COG1279	arginine transmembrane transporter activity
O1449_RS04590	COG0583	DNA-binding transcription factor activity
O1449_RS04630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O1449_RS04635	COG1388	LysM domain
O1449_RS04635	COG0741	lytic transglycosylase activity
O1449_RS04635	COG1388	LysM domain
O1449_RS04635	COG0741	lytic transglycosylase activity
O1449_RS04640	COG4166	transmembrane transport
O1449_RS04645	COG4174	ABC transporter (Permease)
O1449_RS04650	COG4239	(ABC) transporter, permease
O1449_RS04655	COG4172	Belongs to the ABC transporter superfamily
O1449_RS04675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O1449_RS04685	COG2203	Gaf domain
O1449_RS04685	COG5001	Diguanylate cyclase
O1449_RS04685	COG4251	negative regulation of phosphorylation
O1449_RS04685	COG3706	GGDEF domain
O1449_RS04700	COG3739	integral membrane protein
O1449_RS04720	COG0302	gtp cyclohydrolase
O1449_RS04745	COG1823	symporter activity
O1449_RS04750	COG0512	Glutamine amidotransferase of anthranilate synthase
O1449_RS04755	COG0174	glutamine synthetase
O1449_RS04760	COG3161	chorismate lyase activity
O1449_RS04765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O1449_RS04805	COG0436	Aminotransferase
O1449_RS04815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1449_RS04825	COG3706	GGDEF domain
O1449_RS04830	COG0556	nucleotide-excision repair
O1449_RS04895	COG0583	DNA-binding transcription factor activity
O1449_RS04900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O1449_RS04905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1449_RS04910	COG1773	rubredoxin
O1449_RS04920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O1449_RS04935	COG0175	sulfate reduction
O1449_RS04950	COG0222	ribosome binding
O1449_RS04955	COG1253	flavin adenine dinucleotide binding
O1449_RS04970	COG3015	lipoprotein NlpE involved in copper resistance
O1449_RS04990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O1449_RS04990	COG0517	IMP dehydrogenase activity
O1449_RS04995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
O1449_RS05005	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O1449_RS05010	COG1137	ATPase activity
O1449_RS05015	COG1538	Outer membrane efflux protein
O1449_RS05045	COG4122	O-methyltransferase activity
O1449_RS05055	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O1449_RS05150	COG4245	von Willebrand factor, type A
O1449_RS05175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O1449_RS05185	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
O1449_RS05195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O1449_RS05340	COG1610	YqeY-like protein
O1449_RS05370	COG0697	spore germination
O1449_RS05445	COG3210	domain, Protein
O1449_RS05465	COG0482	sulfurtransferase activity
O1449_RS05480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O1449_RS05485	COG1686	Belongs to the peptidase S11 family
O1449_RS05510	COG0583	DNA-binding transcription factor activity
O1449_RS05515	COG1067	ATP-dependent peptidase activity
O1449_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
O1449_RS05565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O1449_RS05570	COG1966	Carbon starvation protein
O1449_RS05575	COG2879	small protein
O1449_RS05580	COG0714	Associated with various cellular activities
O1449_RS05615	COG1741	Belongs to the pirin family
O1449_RS05625	COG1902	pentaerythritol trinitrate reductase activity
O1449_RS05625	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1449_RS05640	COG3311	Transcriptional regulator
O1449_RS05700	COG2217	Heavy metal translocating P-type atpase
O1449_RS05705	COG2205	protein histidine kinase activity
O1449_RS05720	COG2132	Multicopper oxidase
O1449_RS05765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1449_RS05785	COG0640	Transcriptional regulator
O1449_RS05795	COG0798	PFAM Bile acid sodium symporter
O1449_RS05800	COG0431	NADPH-dependent FMN reductase
O1449_RS05805	COG0492	ferredoxin-NADP+ reductase activity
O1449_RS05810	COG0582	viral genome integration into host DNA
O1449_RS05835	COG4771	TonB-dependent receptor
O1449_RS05850	COG2831	hemolysin activation secretion protein
O1449_RS05870	COG1960	acyl-CoA dehydrogenase activity
O1449_RS05910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O1449_RS05920	COG4106	trans-aconitate 2-methyltransferase activity
O1449_RS05925	COG0642	Histidine kinase
O1449_RS05960	COG2188	Transcriptional regulator
O1449_RS05990	COG0010	Belongs to the arginase family
O1449_RS05995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O1449_RS06020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1449_RS06030	COG1294	oxidase, subunit
O1449_RS06035	COG1271	oxidase subunit
O1449_RS06065	COG0243	molybdopterin cofactor binding
O1449_RS06070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O1449_RS06080	COG1538	Outer membrane efflux protein
O1449_RS06085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1449_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1449_RS06095	COG0745	RESPONSE REGULATOR receiver
O1449_RS06100	COG5002	protein histidine kinase activity
O1449_RS06140	COG1309	transcriptional regulator
O1449_RS06160	COG2072	flavoprotein involved in K transport
O1449_RS06165	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
O1449_RS06180	COG0753	catalase activity
O1449_RS06240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O1449_RS06240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O1449_RS06265	COG1278	Cold shock
O1449_RS06270	COG1278	Cold shock
O1449_RS06275	COG1278	Cold shock
O1449_RS06315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O1449_RS06325	COG4770	biotin carboxylase activity
O1449_RS06330	COG0501	Belongs to the peptidase M48B family
O1449_RS06340	COG1765	OsmC-like protein
O1449_RS06345	COG0739	heme binding
O1449_RS06390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O1449_RS06410	COG3634	alkyl hydroperoxide reductase activity
O1449_RS06430	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1449_RS06455	COG1643	Atp-dependent helicase
O1449_RS06470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O1449_RS06495	COG2951	lytic endotransglycosylase activity
O1449_RS06500	COG0772	Belongs to the SEDS family
O1449_RS06515	COG0842	Transport permease protein
O1449_RS06520	COG1131	(ABC) transporter
O1449_RS06590	COG4770	biotin carboxylase activity
O1449_RS06595	COG0864	Transcriptional regulator
O1449_RS06600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1449_RS06620	COG1116	anion transmembrane transporter activity
O1449_RS06630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O1449_RS06635	COG0826	peptidase U32
O1449_RS06685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O1449_RS06690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O1449_RS06710	COG2353	YceI-like domain
O1449_RS06740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1449_RS06750	COG0506	proline dehydrogenase activity
O1449_RS06750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
O1449_RS06750	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
O1449_RS06760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1449_RS06765	COG1027	Aspartate ammonia-lyase
O1449_RS06785	COG1132	(ABC) transporter
O1449_RS06805	COG0668	transmembrane transport
O1449_RS06810	COG3122	Protein conserved in bacteria
O1449_RS06835	COG2363	Small membrane protein
O1449_RS06860	COG0513	Belongs to the DEAD box helicase family
O1449_RS06875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1449_RS06885	COG3178	'Phosphotransferase
O1449_RS06890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O1449_RS06900	COG1192	Involved in chromosome partitioning
O1449_RS06905	COG1475	DNA binding
O1449_RS06910	COG0811	peptide transport
O1449_RS06920	COG1132	(ABC) transporter
O1449_RS06925	COG1663	tetraacyldisaccharide 4'-kinase activity
O1449_RS06945	COG0084	hydrolase, TatD family'
O1449_RS07010	COG0776	regulation of translation
O1449_RS07030	COG2431	L-lysine efflux transmembrane transporter activity
O1449_RS07045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O1449_RS07050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O1449_RS07090	COG0024	Methionine aminopeptidase
O1449_RS07095	COG0583	DNA-binding transcription factor activity
O1449_RS07100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1449_RS07110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O1449_RS07115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1449_RS07120	COG0517	IMP dehydrogenase activity
O1449_RS07145	COG0552	protein localization to endoplasmic reticulum
O1449_RS07175	COG4890	Cyd operon protein YbgT
O1449_RS07180	COG1294	oxidase, subunit
O1449_RS07205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1449_RS07230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O1449_RS07235	COG0569	domain protein
O1449_RS07255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O1449_RS07260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O1449_RS07285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O1449_RS07295	COG0542	response to heat
O1449_RS07310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O1449_RS07315	COG2267	carboxylic ester hydrolase activity
O1449_RS07325	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1449_RS07325	COG1902	pentaerythritol trinitrate reductase activity
O1449_RS07360	COG0148	phosphopyruvate hydratase activity
O1449_RS07365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O1449_RS07425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1449_RS07430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O1449_RS07450	COG1802	Transcriptional regulator
O1449_RS07460	COG2207	Transcriptional regulator
O1449_RS07465	COG1063	alcohol dehydrogenase
O1449_RS07495	COG1944	ATP diphosphatase activity
O1449_RS07515	COG2207	Transcriptional regulator
O1449_RS07530	COG0789	Transcriptional regulator
O1449_RS07550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O1449_RS07555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1449_RS07560	COG0730	response to heat
O1449_RS07580	COG4628	conserved protein (DUF2132)
O1449_RS07635	COG3706	GGDEF domain
O1449_RS07665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1449_RS07680	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
O1449_RS07685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O1449_RS07715	COG0537	adenosine 5'-monophosphoramidase activity
O1449_RS07740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1449_RS07760	COG0730	response to heat
O1449_RS07780	COG4771	TonB-dependent receptor
O1449_RS07800	COG0406	alpha-ribazole phosphatase activity
O1449_RS07805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O1449_RS07820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1449_RS07835	COG2223	nitrite transmembrane transporter activity
O1449_RS07865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O1449_RS07880	COG1960	acyl-CoA dehydrogenase activity
O1449_RS07885	COG1960	acyl-CoA dehydrogenase activity
O1449_RS07890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1449_RS07895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1449_RS07900	COG2207	Transcriptional regulator
O1449_RS07905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1449_RS07915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1449_RS07925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1449_RS07940	COG0575	Belongs to the CDS family
O1449_RS07945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1449_RS07965	COG3852	Histidine kinase
O1449_RS07970	COG2204	response regulator
O1449_RS08020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
O1449_RS08040	COG0697	spore germination
O1449_RS08045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1449_RS08055	COG0303	'Molybdopterin
O1449_RS08060	COG0521	Mo-molybdopterin cofactor biosynthetic process
O1449_RS08060	COG0315	cyclic pyranopterin monophosphate synthase activity
O1449_RS08075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O1449_RS08080	COG0243	molybdopterin cofactor binding
O1449_RS08095	COG0243	molybdopterin cofactor binding
O1449_RS08100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1449_RS08105	COG2146	nitrite reductase [NAD(P)H] activity
O1449_RS08105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1449_RS08110	COG2223	nitrite transmembrane transporter activity
O1449_RS08120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1449_RS08120	COG1116	anion transmembrane transporter activity
O1449_RS08130	COG0511	ligase activity, forming carbon-carbon bonds
O1449_RS08150	COG2814	Major facilitator Superfamily
O1449_RS08155	COG1113	amino acid transport
O1449_RS08165	COG0625	glutathione transferase activity
O1449_RS08180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O1449_RS08195	COG0069	glutamate synthase activity
O1449_RS08215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1449_RS08225	COG1454	alcohol dehydrogenase
O1449_RS08230	COG0824	Thioesterase
O1449_RS08275	COG1358	cellular component organization or biogenesis
O1449_RS08330	COG2850	peptidyl-arginine hydroxylation
O1449_RS08350	COG0640	Transcriptional regulator
O1449_RS08385	COG4650	regulator
O1449_RS08390	COG1234	tRNA 3'-trailer cleavage
O1449_RS08410	COG1690	Belongs to the RtcB family
O1449_RS08435	COG2195	Cleaves the N-terminal amino acid of tripeptides
O1449_RS08445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O1449_RS08460	COG1960	acyl-CoA dehydrogenase activity
O1449_RS08485	COG3139	Protein of unknown function (DUF1315)
O1449_RS08490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O1449_RS08495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1449_RS08505	COG0494	nUDIX hydrolase
O1449_RS08515	COG0642	Histidine kinase
O1449_RS08530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1449_RS08535	COG1720	tRNA m6t6A37 methyltransferase activity
O1449_RS08560	COG0583	DNA-binding transcription factor activity
O1449_RS08580	COG2814	Major facilitator Superfamily
O1449_RS08585	COG3647	Membrane
O1449_RS08625	COG0729	surface antigen
O1449_RS08650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O1449_RS08815	COG1464	Belongs to the NlpA lipoprotein family
O1449_RS08820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1449_RS08825	COG2011	ABC-type metal ion transport system permease component
O1449_RS08830	COG0012	GTP binding
O1449_RS08835	COG3706	GGDEF domain
O1449_RS08840	COG2207	Transcriptional regulator
O1449_RS08860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1449_RS08900	COG1522	sequence-specific DNA binding
O1449_RS08915	COG0386	Belongs to the glutathione peroxidase family
O1449_RS08925	COG0436	Aminotransferase
O1449_RS09015	COG3634	alkyl hydroperoxide reductase activity
O1449_RS09065	COG1286	toxin biosynthetic process
O1449_RS09100	COG1484	DNA-dependent DNA replication
O1449_RS09125	COG4585	Histidine kinase
O1449_RS09175	COG0424	maF-like protein
O1449_RS09205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O1449_RS09220	COG0183	Belongs to the thiolase family
O1449_RS09235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O1449_RS09240	COG0702	epimerase
O1449_RS09245	COG0268	Binds directly to 16S ribosomal RNA
O1449_RS09255	COG1218	3'(2'),5'-bisphosphate nucleotidase
O1449_RS09260	COG1011	Hydrolase
O1449_RS09265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O1449_RS09275	COG2137	regulation of response to DNA damage stimulus
O1449_RS09290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1449_RS09320	COG0822	iron-sulfur transferase activity
O1449_RS09325	COG0316	Belongs to the HesB IscA family
O1449_RS09360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O1449_RS09380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O1449_RS09390	COG3135	benzoate transporter
O1449_RS09395	COG0475	glutathione-regulated potassium exporter activity
O1449_RS09395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O1449_RS09410	COG1714	RDD family
O1449_RS09420	COG0308	aminopeptidase N
O1449_RS09460	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
O1449_RS09470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O1449_RS09480	COG0505	Belongs to the CarA family
O1449_RS09485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1449_RS09495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1449_RS09500	COG0778	Nitroreductase
O1449_RS09505	COG0697	spore germination
O1449_RS09520	COG1923	regulation of RNA biosynthetic process
O1449_RS09530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O1449_RS09535	COG0802	atpase or kinase
O1449_RS09570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1449_RS09595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1449_RS09600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1449_RS09610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O1449_RS09645	COG0305	Participates in initiation and elongation during chromosome replication
O1449_RS09650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O1449_RS09660	COG1305	Transglutaminase-like
O1449_RS09670	COG2308	Evidence 4 Homologs of previously reported genes of
O1449_RS09680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O1449_RS09700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1449_RS09710	COG0527	aspartate kinase activity
O1449_RS09720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O1449_RS09735	COG3038	cytochrome b561
O1449_RS09740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1449_RS09745	COG2252	PERMEase
O1449_RS09825	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
O1449_RS09830	COG0138	bifunctional purine biosynthesis protein purh
O1449_RS09840	COG1464	Belongs to the NlpA lipoprotein family
O1449_RS09845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1449_RS09850	COG2011	ABC-type metal ion transport system permease component
O1449_RS09865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1449_RS09875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
O1449_RS09885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O1449_RS09895	COG0280	phosphate acetyltransferase
O1449_RS09895	COG0281	malic enzyme
O1449_RS09910	COG0052	Belongs to the universal ribosomal protein uS2 family
O1449_RS09915	COG0024	Methionine aminopeptidase
O1449_RS09925	COG2223	nitrite transmembrane transporter activity
O1449_RS09935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1449_RS09940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O1449_RS09945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O1449_RS09975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O1449_RS09990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O1449_RS09995	COG0571	ribonuclease III activity
O1449_RS10010	COG0481	GTPase activity
O1449_RS10020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1449_RS10040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O1449_RS10045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O1449_RS10050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O1449_RS10060	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
O1449_RS10065	COG4208	sulfate ABC transporter
O1449_RS10070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O1449_RS10075	COG0583	DNA-binding transcription factor activity
O1449_RS10090	COG0602	queuosine metabolic process
O1449_RS10095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O1449_RS10110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O1449_RS10135	COG1056	cytidyltransferase-related domain
O1449_RS10135	COG1051	belongs to the nudix hydrolase family
O1449_RS10140	COG1024	Enoyl-CoA hydratase
O1449_RS10145	COG0778	Nitroreductase
O1449_RS10150	COG3323	Protein of unknown function (DUF1653)
O1449_RS10150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O1449_RS10170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1449_RS10170	COG0047	phosphoribosylformylglycinamidine synthase activity
O1449_RS10200	COG2255	four-way junction helicase activity
O1449_RS10205	COG0824	Thioesterase
O1449_RS10225	COG0823	Involved in the tonB-independent uptake of proteins
O1449_RS10245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1449_RS10275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1449_RS10280	COG0628	permease
O1449_RS10290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O1449_RS10305	COG0616	signal peptide processing
O1449_RS10305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O1449_RS10310	COG1560	Kdo2-lipid A biosynthetic process
O1449_RS10315	COG0658	competence protein
O1449_RS10315	COG2333	competence protein COMEC
O1449_RS10320	COG1136	(ABC) transporter
O1449_RS10325	COG4591	ABC-type transport system involved in lipoprotein release permease component
O1449_RS10340	COG1671	Belongs to the UPF0178 family
O1449_RS10365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1449_RS10405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O1449_RS10410	COG1280	lysine exporter protein (LysE YggA)
O1449_RS10415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O1449_RS10430	COG1113	amino acid transport
O1449_RS10435	COG1115	amino acid carrier protein
O1449_RS10450	COG0306	phosphate transporter
O1449_RS10465	COG2852	Protein conserved in bacteria
O1449_RS10470	COG2066	Belongs to the glutaminase family
O1449_RS10475	COG0242	peptide deformylase activity
O1449_RS10495	COG0589	response to stress
O1449_RS10530	COG2175	clavaminate synthase activity
O1449_RS10535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1449_RS10540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
O1449_RS10545	COG4521	taurine ABC transporter
O1449_RS10555	COG1230	cation diffusion facilitator family transporter
O1449_RS10570	COG4149	molybdate abc transporter
O1449_RS10575	COG0725	ABC transporter, periplasmic molybdate-binding protein
O1449_RS10625	COG3046	protein related to deoxyribodipyrimidine photolyase
O1449_RS10635	COG3040	lipid binding
O1449_RS10640	COG1454	alcohol dehydrogenase
O1449_RS10645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O1449_RS10660	COG0833	amino acid
O1449_RS10675	COG1012	belongs to the aldehyde dehydrogenase family
O1449_RS10680	COG3138	arginine N-succinyltransferase
O1449_RS10685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1449_RS10690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O1449_RS10715	COG0281	malic enzyme
O1449_RS10720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1449_RS10725	COG1012	belongs to the aldehyde dehydrogenase family
O1449_RS10735	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1449_RS10740	COG1012	belongs to the aldehyde dehydrogenase family
O1449_RS10745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1449_RS10750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1449_RS10755	COG2267	carboxylic ester hydrolase activity
O1449_RS10795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1449_RS10815	COG0741	lytic transglycosylase activity
O1449_RS10820	COG0501	Belongs to the peptidase M48B family
O1449_RS10830	COG2239	Acts as a magnesium transporter
O1449_RS10835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1449_RS10845	COG0584	glycerophosphoryl diester phosphodiesterase
O1449_RS10870	COG2304	oxidoreductase activity
O1449_RS10875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O1449_RS10880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1449_RS10905	COG0505	Belongs to the CarA family
O1449_RS10940	COG0589	response to stress
O1449_RS10980	COG2321	neutral zinc metallopeptidase
O1449_RS10985	COG2354	Protein conserved in bacteria
O1449_RS10995	COG1585	Membrane protein implicated in regulation of membrane protease activity
O1449_RS11000	COG2268	Band 7 protein
O1449_RS11025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1449_RS11050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O1449_RS11055	COG1053	succinate dehydrogenase
O1449_RS11060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O1449_RS11090	COG1054	Belongs to the UPF0176 family
O1449_RS11095	COG0586	Pfam SNARE associated Golgi protein
O1449_RS11100	COG0500	methyltransferase
O1449_RS11120	COG2921	Belongs to the UPF0250 family
O1449_RS11130	COG0321	lipoyl(octanoyl) transferase activity
O1449_RS11145	COG0531	amino acid
O1449_RS11155	COG1733	regulation of RNA biosynthetic process
O1449_RS11165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O1449_RS11170	COG1648	precorrin-2 dehydrogenase activity
O1449_RS11170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O1449_RS11185	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O1449_RS11200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O1449_RS11215	COG0671	phosphoesterase, PA-phosphatase related
O1449_RS11220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1449_RS11230	COG1538	Outer membrane efflux protein
O1449_RS11235	COG0393	Putative heavy-metal-binding
O1449_RS11240	COG0393	Putative heavy-metal-binding
O1449_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
O1449_RS11270	COG0525	valine-tRNA ligase activity
O1449_RS11295	COG0004	ammonium transporteR
O1449_RS11310	COG0642	Histidine kinase
O1449_RS11315	COG0745	RESPONSE REGULATOR receiver
O1449_RS11320	COG2194	sulfuric ester hydrolase activity
O1449_RS11340	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1449_RS11355	COG2315	Protein conserved in bacteria
O1449_RS11360	COG0142	geranyltranstransferase activity
O1449_RS11365	COG2828	Protein conserved in bacteria
O1449_RS11370	COG1113	amino acid transport
O1449_RS11385	COG0174	glutamine synthetase
O1449_RS11390	COG0671	phosphoesterase, PA-phosphatase related
O1449_RS11395	COG2207	Transcriptional regulator
O1449_RS11405	COG0745	RESPONSE REGULATOR receiver
O1449_RS11410	COG2205	protein histidine kinase activity
O1449_RS11415	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
O1449_RS11420	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
O1449_RS11425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
O1449_RS11440	COG0560	Phosphoserine phosphatase
O1449_RS11450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1449_RS11465	COG0424	maF-like protein
O1449_RS11475	COG1792	Involved in formation and maintenance of cell shape
O1449_RS11480	COG1077	Cell shape determining protein MreB Mrl
O1449_RS11485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O1449_RS11495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O1449_RS11530	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
O1449_RS11535	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1449_RS11540	COG1115	amino acid carrier protein
O1449_RS11545	COG0786	glutamate:sodium symporter activity
O1449_RS11560	COG2814	Major facilitator Superfamily
O1449_RS11565	COG1289	transmembrane transporter activity
O1449_RS11575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O1449_RS11620	COG1376	ErfK ybiS ycfS ynhG family protein
O1449_RS11625	COG2832	Protein of unknown function (DUF454)
O1449_RS11635	COG5510	response to toxic substance
O1449_RS11655	COG0840	transmembrane signaling receptor activity
O1449_RS11685	COG3422	double-strand break repair
O1449_RS11690	COG2824	Alkylphosphonate utilization operon protein PhnA
O1449_RS11710	COG0354	folic acid binding
O1449_RS11715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O1449_RS11745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1449_RS11755	COG1970	mechanosensitive ion channel activity
O1449_RS11760	COG1217	gtp-binding protein TYPA
O1449_RS11765	COG2233	PERMEase
O1449_RS11775	COG0833	amino acid
O1449_RS11780	COG1690	Belongs to the RtcB family
O1449_RS11800	COG0183	Belongs to the thiolase family
O1449_RS11825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1449_RS11840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O1449_RS11845	COG2207	Transcriptional regulator
O1449_RS11855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O1449_RS11865	COG0183	Belongs to the thiolase family
O1449_RS11895	COG2153	protein acetylation
O1449_RS11905	COG1272	protein, Hemolysin III
O1449_RS11910	COG0477	Major facilitator Superfamily
O1449_RS11930	COG0450	alkyl hydroperoxide reductase
O1449_RS11955	COG0285	dihydrofolate synthase activity
O1449_RS12005	COG4206	TonB-dependent receptor
O1449_RS12010	COG2096	Adenosyltransferase
O1449_RS12055	COG0745	RESPONSE REGULATOR receiver
O1449_RS12060	COG2205	protein histidine kinase activity
O1449_RS12070	COG1960	acyl-CoA dehydrogenase activity
O1449_RS12075	COG1960	acyl-CoA dehydrogenase activity
O1449_RS12115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O1449_RS12135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O1449_RS12150	COG1216	Glycosyl transferase, family 2
O1449_RS12150	COG0463	Glycosyl transferase, family 2
O1449_RS12205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O1449_RS12210	COG5002	protein histidine kinase activity
O1449_RS12210	COG2205	protein histidine kinase activity
O1449_RS12210	COG0784	Response regulator, receiver
O1449_RS12215	COG4695	Portal protein
O1449_RS12480	COG1862	Preprotein translocase
O1449_RS12490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1449_RS12545	COG2975	iron-sulfur cluster assembly
O1449_RS12560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O1449_RS12565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O1449_RS12580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O1449_RS12585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O1449_RS12595	COG0625	glutathione transferase activity
O1449_RS12600	COG2969	positive regulation of protein catabolic process
O1449_RS12630	COG3568	Endonuclease Exonuclease Phosphatase
O1449_RS12660	COG1960	acyl-CoA dehydrogenase activity
O1449_RS12665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1449_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
O1449_RS12700	COG1960	acyl-CoA dehydrogenase activity
O1449_RS12705	COG1960	acyl-CoA dehydrogenase activity
O1449_RS12770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1449_RS12780	COG1846	Transcriptional regulator
O1449_RS12785	COG1764	response to oxidative stress
O1449_RS12810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1449_RS12810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1449_RS12825	COG0037	tRNA processing
O1449_RS12835	COG0248	Ppx GppA phosphatase
O1449_RS12860	COG0072	phenylalanine-tRNA ligase activity
O1449_RS12895	COG1238	metal cluster binding
O1449_RS12905	COG0625	glutathione transferase activity
O1449_RS12910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O1449_RS12920	COG0318	PFAM AMP-dependent synthetase and ligase
O1449_RS12925	COG3028	Belongs to the UPF0307 family
O1449_RS12950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O1449_RS12955	COG0617	tRNA 3'-terminal CCA addition
O1449_RS12960	COG1555	photosystem II stabilization
O1449_RS12965	COG3956	TIGRFAM MazG family protein
O1449_RS12975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1449_RS12995	COG5002	protein histidine kinase activity
O1449_RS12995	COG2205	protein histidine kinase activity
O1449_RS12995	COG0784	Response regulator, receiver
O1449_RS13005	COG2084	Dehydrogenase
O1449_RS13010	COG3622	Belongs to the hyi family
O1449_RS13025	COG0004	ammonium transporteR
O1449_RS13050	COG0789	Transcriptional regulator
O1449_RS13060	COG2814	Major facilitator Superfamily
O1449_RS13065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O1449_RS13070	COG1162	GTPase activity
O1449_RS13080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O1449_RS13095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O1449_RS13110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O1449_RS13120	COG3781	membrane
O1449_RS13160	COG1666	GTP binding
O1449_RS13170	COG1607	acyl-coa hydrolase
O1449_RS13225	COG2199	diguanylate cyclase activity
O1449_RS13235	COG1408	metallophosphoesterase
O1449_RS13240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1449_RS13255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O1449_RS13280	COG0793	Belongs to the peptidase S41A family
O1449_RS13305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O1449_RS13310	COG0857	belongs to the CobB CobQ family
O1449_RS13310	COG0280	phosphate acetyltransferase
O1449_RS13320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
O1449_RS13320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
O1449_RS13345	COG0740	serine-type endopeptidase activity
O1449_RS13355	COG4774	siderophore transport
O1449_RS13360	COG3128	pkhd-type hydroxylase
O1449_RS13370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1449_RS13380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O1449_RS13380	COG2813	Specifically methylates the guanine in position
O1449_RS13405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1449_RS13435	COG1295	ribonuclease BN
O1449_RS13440	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1449_RS13475	COG0557	exoribonuclease II activity
O1449_RS13490	COG0339	signal peptide processing
O1449_RS13540	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
O1449_RS13545	COG1960	acyl-CoA dehydrogenase activity
O1449_RS13610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O1449_RS13625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O1449_RS13675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O1449_RS13690	COG0088	Forms part of the polypeptide exit tunnel
O1449_RS13695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O1449_RS13710	COG0626	cystathionine gamma-synthase activity
O1449_RS13715	COG0433	COG0433 Predicted ATPase
O1449_RS13725	COG1959	2 iron, 2 sulfur cluster binding
O1449_RS13740	COG1301	dicarboxylic acid transport
O1449_RS13745	COG1946	Acyl-CoA thioesterase
O1449_RS13750	COG2937	Belongs to the GPAT DAPAT family
O1449_RS13765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O1449_RS13770	COG1040	competence protein
O1449_RS13775	COG0494	nUDIX hydrolase
O1449_RS13785	COG0598	Magnesium transport protein CorA
O1449_RS13795	COG2854	intermembrane phospholipid transfer
O1449_RS13800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O1449_RS13805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O1449_RS13810	COG1127	ABC transporter
O1449_RS13835	COG0408	coproporphyrinogen oxidase activity
O1449_RS13850	COG1960	acyl-CoA dehydrogenase activity
O1449_RS13865	COG1983	PspC domain protein
O1449_RS13870	COG0517	IMP dehydrogenase activity
O1449_RS13975	COG2226	methyltransferase
O1449_RS13985	COG1192	Involved in chromosome partitioning
O1449_RS13990	COG0628	permease
O1449_RS14015	COG2249	NAD(P)H dehydrogenase (quinone) activity
O1449_RS14020	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O1449_RS14030	COG0277	FAD linked oxidase domain protein
O1449_RS14035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1449_RS14060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O1449_RS14065	COG5380	lipid catabolic process
O1449_RS14070	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O1449_RS14075	COG0335	large ribosomal subunit rRNA binding
O1449_RS14085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O1449_RS14090	COG0228	four-way junction DNA binding
O1449_RS14130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O1449_RS14135	COG0194	GDP metabolic process
O1449_RS14145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1449_RS14165	COG3307	-O-antigen
O1449_RS14185	COG0438	transferase activity, transferring glycosyl groups
O1449_RS14195	COG0662	Cupin 2, conserved barrel domain protein
O1449_RS14195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
O1449_RS14200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O1449_RS14210	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
O1449_RS14225	COG1132	(ABC) transporter
O1449_RS14230	COG2226	methyltransferase
O1449_RS14255	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O1449_RS14260	COG1704	LemA family
O1449_RS14270	COG0493	'glutamate synthase
O1449_RS14275	COG0067	glutamate synthase
O1449_RS14275	COG0069	glutamate synthase activity
O1449_RS14275	COG0070	glutamate synthase
O1449_RS14325	COG2226	methyltransferase
O1449_RS14335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O1449_RS14340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O1449_RS14360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O1449_RS14385	COG0833	amino acid
O1449_RS14445	COG0488	(ABC) transporter
O1449_RS14450	COG2873	o-acetylhomoserine
O1449_RS14455	COG4221	oxidoreductase activity
O1449_RS14465	COG0789	Transcriptional regulator
O1449_RS14505	COG0427	acetyl-CoA hydrolase
O1449_RS14535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O1449_RS14540	COG3152	Membrane
O1449_RS14565	COG2329	Antibiotic biosynthesis monooxygenase
O1449_RS14580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1449_RS14640	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
O1449_RS14655	COG1012	belongs to the aldehyde dehydrogenase family
O1449_RS14660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1449_RS14670	COG1113	amino acid transport
O1449_RS14680	COG2814	Major facilitator Superfamily
O1449_RS14690	COG0351	phosphomethylpyrimidine kinase
O1449_RS14690	COG0352	thiamine-phosphate diphosphorylase activity
O1449_RS14690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O1449_RS14700	COG3321	synthase
O1449_RS14700	COG0604	alcohol dehydrogenase
O1449_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
O1449_RS14705	COG1309	transcriptional regulator
O1449_RS14755	COG1522	sequence-specific DNA binding
O1449_RS14760	COG1335	isochorismatase
O1449_RS14765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1449_RS14775	COG0668	transmembrane transport
O1449_RS14780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O1449_RS14785	COG1519	Transferase
O1449_RS14795	COG1902	pentaerythritol trinitrate reductase activity
O1449_RS14815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O1449_RS14835	COG0426	domain, Protein
O1449_RS14835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1449_RS14840	COG2119	membrane
O1449_RS14875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O1449_RS14885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O1449_RS14905	COG0189	ligase activity
O1449_RS14910	COG0386	Belongs to the glutathione peroxidase family
O1449_RS14940	COG0708	Exodeoxyribonuclease III
O1449_RS15035	COG0534	Mate efflux family protein
O1449_RS15055	COG3150	esterase
O1449_RS15070	COG2918	glutathione biosynthetic process
O1449_RS15085	COG2733	membrane
O1449_RS15095	COG0436	Aminotransferase
O1449_RS15100	COG0534	Mate efflux family protein
O1449_RS15140	COG0583	DNA-binding transcription factor activity
O1449_RS15200	COG0560	Phosphoserine phosphatase
O1449_RS15200	COG3830	Belongs to the UPF0237 family
O1449_RS15225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O1449_RS15230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O1449_RS15240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O1449_RS15250	COG1522	sequence-specific DNA binding
O1449_RS15255	COG1335	isochorismatase
O1449_RS15260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1449_RS15270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O1449_RS15275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O1449_RS15290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O1449_RS15300	COG2983	Belongs to the UPF0260 family
O1449_RS15305	COG5487	UPF0391 membrane protein
O1449_RS15315	COG1194	a g-specific adenine glycosylase
O1449_RS15330	COG2818	Glycosylase
O1449_RS15335	COG1064	alcohol dehydrogenase
O1449_RS15340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1449_RS15350	COG0583	DNA-binding transcription factor activity
O1449_RS15355	COG0656	L-ascorbic acid biosynthetic process
O1449_RS15360	COG2814	Major facilitator Superfamily
O1449_RS15370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O1449_RS15390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1449_RS15395	COG1309	transcriptional regulator
O1449_RS15405	COG2233	PERMEase
O1449_RS15440	COG0733	neurotransmitter:sodium symporter activity
O1449_RS15445	COG1012	belongs to the aldehyde dehydrogenase family
O1449_RS15490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1449_RS15495	COG0657	acetylesterase activity
O1449_RS15510	COG0583	DNA-binding transcription factor activity
O1449_RS15520	COG0443	Heat shock 70 kDa protein
O1449_RS15525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O1449_RS15550	COG2951	lytic endotransglycosylase activity
O1449_RS15555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O1449_RS15575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O1449_RS15600	COG0583	DNA-binding transcription factor activity
O1449_RS15605	COG0861	Integral membrane protein TerC family
O1449_RS15615	COG0754	glutathionylspermidine amidase activity
O1449_RS15630	COG0402	S-adenosylhomocysteine deaminase activity
O1449_RS15645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O1449_RS15685	COG3617	BRO family, N-terminal domain
O1449_RS15705	COG0582	viral genome integration into host DNA
O1449_RS15715	COG0706	membrane insertase activity
O1449_RS15810	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
O1449_RS15850	COG2801	Transposase and inactivated derivatives
O1449_RS15860	COG3791	Glutathione-dependent formaldehyde-activating
O1449_RS15865	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O1449_RS15880	COG1252	NADH dehydrogenase
O1449_RS15890	COG4115	mRNA cleavage
O1449_RS16170	COG3609	addiction module antidote protein, CC2985 family