locus-tag	class	description
H0S58_RS00010	COG0592	DNA-directed DNA polymerase activity
H0S58_RS00030	COG0488	(ABC) transporter
H0S58_RS00065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H0S58_RS00070	COG0443	Heat shock 70 kDa protein
H0S58_RS00090	COG0657	acetylesterase activity
H0S58_RS00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S58_RS00130	COG2133	pyrroloquinoline quinone binding
H0S58_RS00140	COG1047	Peptidyl-prolyl cis-trans
H0S58_RS00150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S58_RS00155	COG0196	riboflavin kinase activity
H0S58_RS00170	COG1309	transcriptional regulator
H0S58_RS00175	COG1116	anion transmembrane transporter activity
H0S58_RS00180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S58_RS00185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S58_RS00190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S58_RS00195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S58_RS00200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S58_RS00200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0S58_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS00225	COG0546	phosphoglycolate phosphatase activity
H0S58_RS00230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0S58_RS00255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S58_RS00280	COG5487	UPF0391 membrane protein
H0S58_RS00285	COG2983	Belongs to the UPF0260 family
H0S58_RS00290	COG5001	Diguanylate cyclase
H0S58_RS00290	COG3300	MHYT domain
H0S58_RS00295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0S58_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S58_RS00315	COG1335	isochorismatase
H0S58_RS00320	COG0385	Bile acid
H0S58_RS00330	COG3830	Belongs to the UPF0237 family
H0S58_RS00330	COG0560	Phosphoserine phosphatase
H0S58_RS00380	COG2733	membrane
H0S58_RS00395	COG2918	glutathione biosynthetic process
H0S58_RS00410	COG3150	esterase
H0S58_RS00450	COG3706	GGDEF domain
H0S58_RS00455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H0S58_RS00470	COG1393	Belongs to the ArsC family
H0S58_RS00475	COG0708	Exodeoxyribonuclease III
H0S58_RS00480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0S58_RS00500	COG1846	Transcriptional regulator
H0S58_RS00505	COG0386	Belongs to the glutathione peroxidase family
H0S58_RS00510	COG0189	ligase activity
H0S58_RS00520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S58_RS00530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S58_RS00570	COG2119	membrane
H0S58_RS00595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S58_RS00615	COG1902	pentaerythritol trinitrate reductase activity
H0S58_RS00620	COG1519	Transferase
H0S58_RS00625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S58_RS00630	COG0668	transmembrane transport
H0S58_RS00640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S58_RS00660	COG0431	NADPH-dependent FMN reductase
H0S58_RS00675	COG2205	protein histidine kinase activity
H0S58_RS00675	COG2198	Histidine kinase
H0S58_RS00675	COG0784	Response regulator, receiver
H0S58_RS00680	COG3162	membrane
H0S58_RS00685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S58_RS00695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S58_RS00725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S58_RS00725	COG0352	thiamine-phosphate diphosphorylase activity
H0S58_RS00725	COG0351	phosphomethylpyrimidine kinase
H0S58_RS00735	COG2814	Major facilitator Superfamily
H0S58_RS00740	COG0629	single-stranded DNA binding
H0S58_RS00760	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H0S58_RS00795	COG3158	transport of potassium into the cell
H0S58_RS00835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S58_RS00860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S58_RS00950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S58_RS00965	COG3275	phosphorelay sensor kinase activity
H0S58_RS00975	COG0181	hydroxymethylbilane synthase activity
H0S58_RS00995	COG0824	Thioesterase
H0S58_RS01025	COG0546	phosphoglycolate phosphatase activity
H0S58_RS01060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H0S58_RS01070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0S58_RS01075	COG0081	regulation of translation
H0S58_RS01080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0S58_RS01085	COG0222	ribosome binding
H0S58_RS01090	COG0085	RNA polymerase activity
H0S58_RS01095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0S58_RS01115	COG2056	Na+-H+ antiporter family
H0S58_RS01130	COG0326	Molecular chaperone. Has ATPase activity
H0S58_RS01160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S58_RS01170	COG0427	acetyl-CoA hydrolase
H0S58_RS01195	COG4221	oxidoreductase activity
H0S58_RS01205	COG0488	(ABC) transporter
H0S58_RS01270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S58_RS01285	COG0768	penicillin binding
H0S58_RS01290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S58_RS01295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S58_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0S58_RS01305	COG2226	methyltransferase
H0S58_RS01355	COG0067	glutamate synthase
H0S58_RS01355	COG0069	glutamate synthase activity
H0S58_RS01355	COG0070	glutamate synthase
H0S58_RS01360	COG0493	'glutamate synthase
H0S58_RS01370	COG1704	LemA family
H0S58_RS01390	COG3307	-O-antigen
H0S58_RS01400	COG3307	-O-antigen
H0S58_RS01420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S58_RS01425	COG1758	RNA polymerase activity
H0S58_RS01430	COG0194	GDP metabolic process
H0S58_RS01475	COG0228	four-way junction DNA binding
H0S58_RS01480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S58_RS01490	COG0335	large ribosomal subunit rRNA binding
H0S58_RS01500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H0S58_RS01505	COG5380	lipid catabolic process
H0S58_RS01510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S58_RS01530	COG5006	permease, DMT superfamily
H0S58_RS01535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S58_RS01540	COG0277	FAD linked oxidase domain protein
H0S58_RS01555	COG1289	transmembrane transporter activity
H0S58_RS01560	COG2032	superoxide dismutase activity
H0S58_RS01565	COG0628	permease
H0S58_RS01570	COG1192	Involved in chromosome partitioning
H0S58_RS01580	COG2226	methyltransferase
H0S58_RS01600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0S58_RS01605	COG0254	rRNA binding
H0S58_RS01610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S58_RS01615	COG0534	Mate efflux family protein
H0S58_RS01625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S58_RS01630	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS01640	COG0408	coproporphyrinogen oxidase activity
H0S58_RS01660	COG0513	Belongs to the DEAD box helicase family
H0S58_RS01665	COG1127	ABC transporter
H0S58_RS01670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S58_RS01675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S58_RS01680	COG2854	intermembrane phospholipid transfer
H0S58_RS01690	COG0598	Magnesium transport protein CorA
H0S58_RS01705	COG1040	competence protein
H0S58_RS01710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S58_RS01720	COG2937	Belongs to the GPAT DAPAT family
H0S58_RS01725	COG1946	Acyl-CoA thioesterase
H0S58_RS01730	COG1301	dicarboxylic acid transport
H0S58_RS01745	COG1959	2 iron, 2 sulfur cluster binding
H0S58_RS01755	COG0433	COG0433 Predicted ATPase
H0S58_RS01770	COG0051	transcription antitermination factor activity, RNA binding
H0S58_RS01780	COG0088	Forms part of the polypeptide exit tunnel
H0S58_RS01785	COG0089	rRNA binding
H0S58_RS01795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0S58_RS01800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0S58_RS01805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0S58_RS01825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0S58_RS01830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0S58_RS01840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0S58_RS01845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0S58_RS01860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0S58_RS01895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0S58_RS01900	COG0202	RNA polymerase activity
H0S58_RS01905	COG0203	ribosomal protein L17
H0S58_RS01910	COG2072	flavoprotein involved in K transport
H0S58_RS01915	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS01920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S58_RS01950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S58_RS01955	COG0339	signal peptide processing
H0S58_RS01965	COG0557	exoribonuclease II activity
H0S58_RS02000	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S58_RS02005	COG1295	ribonuclease BN
H0S58_RS02050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0S58_RS02055	COG1702	phosphate starvation-inducible protein PhoH
H0S58_RS02060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0S58_RS02065	COG0739	heme binding
H0S58_RS02065	COG0741	lytic transglycosylase activity
H0S58_RS02065	COG1196	nuclear chromosome segregation
H0S58_RS02075	COG0039	L-malate dehydrogenase activity
H0S58_RS02100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S58_RS02105	COG1183	phosphatidylcholine synthase activity
H0S58_RS02165	COG1607	acyl-coa hydrolase
H0S58_RS02210	COG3781	membrane
H0S58_RS02215	COG2003	Belongs to the UPF0758 family
H0S58_RS02220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S58_RS02225	COG3783	Cytochrome b(562)
H0S58_RS02230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S58_RS02235	COG2814	Major facilitator Superfamily
H0S58_RS02240	COG0697	spore germination
H0S58_RS02270	COG3622	Belongs to the hyi family
H0S58_RS02275	COG2084	Dehydrogenase
H0S58_RS02280	COG1024	Enoyl-CoA hydratase
H0S58_RS02305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S58_RS02320	COG1862	Preprotein translocase
H0S58_RS02330	COG1704	LemA family
H0S58_RS02340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0S58_RS02350	COG5002	protein histidine kinase activity
H0S58_RS02350	COG0784	Response regulator, receiver
H0S58_RS02350	COG2205	protein histidine kinase activity
H0S58_RS02355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S58_RS02375	COG0726	polysaccharide deacetylase
H0S58_RS02380	COG0463	Glycosyl transferase, family 2
H0S58_RS02410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0S58_RS02425	COG1216	Glycosyl transferase, family 2
H0S58_RS02425	COG0463	Glycosyl transferase, family 2
H0S58_RS02440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0S58_RS02475	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS02480	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS02490	COG2205	protein histidine kinase activity
H0S58_RS02495	COG0745	RESPONSE REGULATOR receiver
H0S58_RS02500	COG2315	Protein conserved in bacteria
H0S58_RS02520	COG2096	Adenosyltransferase
H0S58_RS02525	COG4206	TonB-dependent receptor
H0S58_RS02565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0S58_RS02570	COG0285	dihydrofolate synthase activity
H0S58_RS02590	COG0450	alkyl hydroperoxide reductase
H0S58_RS02605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S58_RS02680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S58_RS02685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S58_RS02735	COG0494	nUDIX hydrolase
H0S58_RS02745	COG1214	PFAM Peptidase M22, glycoprotease
H0S58_RS02750	COG1968	undecaprenyl-diphosphatase activity
H0S58_RS02775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S58_RS02785	COG2132	Multicopper oxidase
H0S58_RS02800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S58_RS02830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S58_RS02835	COG3545	Serine hydrolase
H0S58_RS02850	COG0730	response to heat
H0S58_RS02860	COG1196	nuclear chromosome segregation
H0S58_RS02870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0S58_RS02875	COG2193	ferroxidase activity
H0S58_RS02880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S58_RS02885	COG2226	methyltransferase
H0S58_RS02885	COG0596	Alpha beta hydrolase
H0S58_RS02885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S58_RS02900	COG4106	trans-aconitate 2-methyltransferase activity
H0S58_RS02915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S58_RS02920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S58_RS02930	COG0009	L-threonylcarbamoyladenylate synthase
H0S58_RS02935	COG3101	peptidyl-lysine hydroxylation
H0S58_RS02940	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S58_RS02955	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS02965	COG0833	amino acid
H0S58_RS02975	COG2233	PERMEase
H0S58_RS02980	COG1217	gtp-binding protein TYPA
H0S58_RS02990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S58_RS03010	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S58_RS03010	COG1024	Enoyl-CoA hydratase
H0S58_RS03015	COG0183	Belongs to the thiolase family
H0S58_RS03020	COG2207	Transcriptional regulator
H0S58_RS03025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S58_RS03055	COG0183	Belongs to the thiolase family
H0S58_RS03075	COG1652	LysM domain
H0S58_RS03100	COG3676	manually curated
H0S58_RS03110	COG1538	Outer membrane efflux protein
H0S58_RS03180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S58_RS03195	COG0745	RESPONSE REGULATOR receiver
H0S58_RS03200	COG2205	protein histidine kinase activity
H0S58_RS03210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S58_RS03230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S58_RS03245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S58_RS03255	COG0713	ATP synthesis coupled electron transport
H0S58_RS03260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S58_RS03265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S58_RS03275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0S58_RS03290	COG0583	DNA-binding transcription factor activity
H0S58_RS03310	COG0668	transmembrane transport
H0S58_RS03320	COG2081	HI0933 family
H0S58_RS03325	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S58_RS03365	COG1090	epimerase
H0S58_RS03370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S58_RS03380	COG2050	protein possibly involved in aromatic compounds catabolism
H0S58_RS03390	COG2814	Major facilitator Superfamily
H0S58_RS03450	COG0442	prolyl-tRNA aminoacylation
H0S58_RS03485	COG0840	transmembrane signaling receptor activity
H0S58_RS03490	COG0643	Histidine kinase
H0S58_RS03490	COG2198	Histidine kinase
H0S58_RS03490	COG0784	Response regulator, receiver
H0S58_RS03515	COG2832	Protein of unknown function (DUF454)
H0S58_RS03520	COG1376	ErfK ybiS ycfS ynhG family protein
H0S58_RS03575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S58_RS03585	COG1289	transmembrane transporter activity
H0S58_RS03590	COG2814	Major facilitator Superfamily
H0S58_RS03605	COG0786	glutamate:sodium symporter activity
H0S58_RS03615	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S58_RS03620	COG1607	acyl-coa hydrolase
H0S58_RS03630	COG0523	cobalamin synthesis protein
H0S58_RS03635	COG4681	YaeQ
H0S58_RS03645	COG2203	Gaf domain
H0S58_RS03645	COG2199	diguanylate cyclase activity
H0S58_RS03650	COG0454	-acetyltransferase
H0S58_RS03660	COG1215	transferase activity, transferring glycosyl groups
H0S58_RS03700	COG0242	peptide deformylase activity
H0S58_RS03710	COG0306	phosphate transporter
H0S58_RS03735	COG4771	TonB-dependent receptor
H0S58_RS03760	COG4181	ATPase activity
H0S58_RS03765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S58_RS03785	COG0583	DNA-binding transcription factor activity
H0S58_RS03795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S58_RS03800	COG1773	rubredoxin
H0S58_RS03805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0S58_RS03830	COG2354	Protein conserved in bacteria
H0S58_RS03835	COG2321	neutral zinc metallopeptidase
H0S58_RS03855	COG3695	enzyme binding
H0S58_RS03875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0S58_RS03880	COG0505	Belongs to the CarA family
H0S58_RS03905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S58_RS03910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S58_RS03940	COG2851	Citrate transporter
H0S58_RS03945	COG1253	flavin adenine dinucleotide binding
H0S58_RS03960	COG0584	glycerophosphoryl diester phosphodiesterase
H0S58_RS03970	COG2239	Acts as a magnesium transporter
H0S58_RS03985	COG0501	Belongs to the peptidase M48B family
H0S58_RS03990	COG0739	heme binding
H0S58_RS03990	COG1196	nuclear chromosome segregation
H0S58_RS03990	COG0741	lytic transglycosylase activity
H0S58_RS03995	COG0037	tRNA processing
H0S58_RS04005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H0S58_RS04010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S58_RS04035	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S58_RS04035	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S58_RS04040	COG0303	'Molybdopterin
H0S58_RS04045	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S58_RS04050	COG4149	molybdate abc transporter
H0S58_RS04055	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0S58_RS04075	COG0583	DNA-binding transcription factor activity
H0S58_RS04080	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS04090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H0S58_RS04110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S58_RS04120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S58_RS04165	COG1113	amino acid transport
H0S58_RS04175	COG0019	diaminopimelate decarboxylase activity
H0S58_RS04190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S58_RS04200	COG1522	sequence-specific DNA binding
H0S58_RS04205	COG1280	lysine exporter protein (LysE YggA)
H0S58_RS04250	COG1301	dicarboxylic acid transport
H0S58_RS04265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S58_RS04290	COG1671	Belongs to the UPF0178 family
H0S58_RS04295	COG0697	spore germination
H0S58_RS04310	COG1136	(ABC) transporter
H0S58_RS04315	COG2333	competence protein COMEC
H0S58_RS04315	COG0658	competence protein
H0S58_RS04335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S58_RS04345	COG0628	permease
H0S58_RS04350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S58_RS04380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S58_RS04395	COG2885	chlorophyll binding
H0S58_RS04400	COG0823	Involved in the tonB-independent uptake of proteins
H0S58_RS04420	COG0824	Thioesterase
H0S58_RS04425	COG1473	amidohydrolase
H0S58_RS04435	COG2255	four-way junction helicase activity
H0S58_RS04440	COG0632	four-way junction helicase activity
H0S58_RS04455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S58_RS04455	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S58_RS04470	COG0778	Nitroreductase
H0S58_RS04475	COG1024	Enoyl-CoA hydratase
H0S58_RS04480	COG1056	cytidyltransferase-related domain
H0S58_RS04480	COG1051	belongs to the nudix hydrolase family
H0S58_RS04485	COG2353	YceI-like domain
H0S58_RS04490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S58_RS04505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S58_RS04510	COG0602	queuosine metabolic process
H0S58_RS04525	COG0583	DNA-binding transcription factor activity
H0S58_RS04530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S58_RS04535	COG4208	sulfate ABC transporter
H0S58_RS04550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S58_RS04560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S58_RS04580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S58_RS04595	COG0681	Belongs to the peptidase S26 family
H0S58_RS04610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S58_RS04625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S58_RS04635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S58_RS04645	COG2175	clavaminate synthase activity
H0S58_RS04665	COG2199	diguanylate cyclase activity
H0S58_RS04675	COG0556	nucleotide-excision repair
H0S58_RS04685	COG2962	Rard protein
H0S58_RS04705	COG0702	epimerase
H0S58_RS04710	COG1733	regulation of RNA biosynthetic process
H0S58_RS04720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0S58_RS04725	COG0671	phosphoesterase, PA-phosphatase related
H0S58_RS04735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S58_RS04740	COG0076	glutamate decarboxylase activity
H0S58_RS04745	COG2271	Major facilitator Superfamily
H0S58_RS04750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S58_RS04755	COG0573	inorganic phosphate transmembrane transporter activity
H0S58_RS04765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S58_RS04770	COG0616	signal peptide processing
H0S58_RS04795	COG0482	sulfurtransferase activity
H0S58_RS04805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S58_RS04810	COG1686	Belongs to the peptidase S11 family
H0S58_RS04835	COG0583	DNA-binding transcription factor activity
H0S58_RS04840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S58_RS04845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S58_RS04850	COG1067	ATP-dependent peptidase activity
H0S58_RS04870	COG0254	rRNA binding
H0S58_RS04885	COG1509	lysine 2,3-aminomutase activity
H0S58_RS04895	COG1966	Carbon starvation protein
H0S58_RS04900	COG2879	small protein
H0S58_RS04905	COG0714	Associated with various cellular activities
H0S58_RS04925	COG1027	Aspartate ammonia-lyase
H0S58_RS04930	COG0583	DNA-binding transcription factor activity
H0S58_RS04935	COG1301	dicarboxylic acid transport
H0S58_RS04955	COG3634	alkyl hydroperoxide reductase activity
H0S58_RS04960	COG0789	Transcriptional regulator
H0S58_RS04985	COG1720	tRNA m6t6A37 methyltransferase activity
H0S58_RS04990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0S58_RS05005	COG0642	Histidine kinase
H0S58_RS05015	COG0494	nUDIX hydrolase
H0S58_RS05025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S58_RS05030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S58_RS05035	COG3139	Protein of unknown function (DUF1315)
H0S58_RS05040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S58_RS05040	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S58_RS05045	COG1301	dicarboxylic acid transport
H0S58_RS05050	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS05060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S58_RS05085	COG0415	Belongs to the DNA photolyase family
H0S58_RS05090	COG2252	PERMEase
H0S58_RS05095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S58_RS05105	COG3038	cytochrome b561
H0S58_RS05115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S58_RS05125	COG0527	aspartate kinase activity
H0S58_RS05130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0S58_RS05135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0S58_RS05155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S58_RS05170	COG0667	Aldo Keto reductase
H0S58_RS05180	COG1765	OsmC-like protein
H0S58_RS05210	COG0540	Belongs to the ATCase OTCase family
H0S58_RS05235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S58_RS05240	COG0659	secondary active sulfate transmembrane transporter activity
H0S58_RS05250	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S58_RS05255	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H0S58_RS05270	COG2363	Small membrane protein
H0S58_RS05285	COG1278	Cold shock
H0S58_RS05290	COG0513	Belongs to the DEAD box helicase family
H0S58_RS05300	COG0778	Nitroreductase
H0S58_RS05325	COG0167	dihydroorotate dehydrogenase activity
H0S58_RS05330	COG1286	toxin biosynthetic process
H0S58_RS05355	COG4783	chaperone-mediated protein folding
H0S58_RS05400	COG2815	serine threonine protein kinase
H0S58_RS05400	COG0515	serine threonine protein kinase
H0S58_RS05425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S58_RS05435	COG0612	Peptidase, M16
H0S58_RS05455	COG3025	triphosphatase activity
H0S58_RS05465	COG0352	thiamine-phosphate diphosphorylase activity
H0S58_RS05480	COG3293	Transposase
H0S58_RS05500	COG1309	transcriptional regulator
H0S58_RS05560	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0S58_RS05580	COG1522	sequence-specific DNA binding
H0S58_RS05610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S58_RS05630	COG1271	oxidase subunit
H0S58_RS05635	COG1294	oxidase, subunit
H0S58_RS05645	COG1525	nuclease
H0S58_RS05685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S58_RS05700	COG1113	amino acid transport
H0S58_RS05710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S58_RS05715	COG2814	Major facilitator Superfamily
H0S58_RS05720	COG0509	glycine decarboxylation via glycine cleavage system
H0S58_RS05735	COG1132	(ABC) transporter
H0S58_RS05795	COG0668	transmembrane transport
H0S58_RS05800	COG3122	Protein conserved in bacteria
H0S58_RS05820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S58_RS05835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S58_RS05840	COG0183	Belongs to the thiolase family
H0S58_RS05845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S58_RS05850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S58_RS05855	COG3135	benzoate transporter
H0S58_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS05865	COG0543	2 iron, 2 sulfur cluster binding
H0S58_RS05865	COG0633	Ferredoxin
H0S58_RS05870	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S58_RS05875	COG4638	Rieske (2fe-2S)
H0S58_RS05885	COG4829	muconolactone delta-isomerase
H0S58_RS05890	COG4948	Mandelate Racemase Muconate Lactonizing
H0S58_RS05895	COG0583	DNA-binding transcription factor activity
H0S58_RS05900	COG2814	Major facilitator Superfamily
H0S58_RS05910	COG1846	Transcriptional regulator
H0S58_RS05920	COG2814	Major facilitator Superfamily
H0S58_RS05925	COG2031	fatty acid transporter
H0S58_RS05930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S58_RS05945	COG4770	biotin carboxylase activity
H0S58_RS05955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S58_RS05965	COG1309	transcriptional regulator
H0S58_RS05970	COG0318	PFAM AMP-dependent synthetase and ligase
H0S58_RS05980	COG0644	oxidoreductase
H0S58_RS05980	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S58_RS05995	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS06005	COG0183	Belongs to the thiolase family
H0S58_RS06010	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S58_RS06015	COG1024	Enoyl-CoA hydratase
H0S58_RS06020	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS06025	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS06030	COG2814	Major facilitator Superfamily
H0S58_RS06040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S58_RS06050	COG2814	Major facilitator Superfamily
H0S58_RS06060	COG2814	Major facilitator Superfamily
H0S58_RS06065	COG1846	Transcriptional regulator
H0S58_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS06075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H0S58_RS06085	COG0318	PFAM AMP-dependent synthetase and ligase
H0S58_RS06115	COG2223	nitrite transmembrane transporter activity
H0S58_RS06120	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0S58_RS06150	COG2814	Major facilitator Superfamily
H0S58_RS06160	COG4264	IucA IucC family
H0S58_RS06200	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS06205	COG1024	Enoyl-CoA hydratase
H0S58_RS06220	COG1944	ATP diphosphatase activity
H0S58_RS06250	COG4607	ABC-type enterochelin transport system periplasmic component
H0S58_RS06255	COG4604	ABC transporter, ATP-binding protein
H0S58_RS06260	COG4605	iron ion homeostasis
H0S58_RS06265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0S58_RS06285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S58_RS06310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S58_RS06325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S58_RS06355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0S58_RS06360	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0S58_RS06365	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H0S58_RS06370	COG2205	protein histidine kinase activity
H0S58_RS06380	COG3550	peptidyl-serine autophosphorylation
H0S58_RS06390	COG4628	conserved protein (DUF2132)
H0S58_RS06530	COG0653	protein targeting
H0S58_RS06580	COG0596	Alpha beta hydrolase
H0S58_RS06625	COG0511	ligase activity, forming carbon-carbon bonds
H0S58_RS06630	COG0439	Biotin carboxylase
H0S58_RS06665	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S58_RS06665	COG1902	pentaerythritol trinitrate reductase activity
H0S58_RS06685	COG0024	Methionine aminopeptidase
H0S58_RS06690	COG1114	Component of the transport system for branched-chain amino acids
H0S58_RS06730	COG0786	glutamate:sodium symporter activity
H0S58_RS06810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H0S58_RS06820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0S58_RS06825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S58_RS06845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S58_RS06855	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S58_RS06860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0S58_RS06875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S58_RS06880	COG4682	membrane
H0S58_RS06910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0S58_RS06915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S58_RS06920	COG1845	cytochrome c oxidase, subunit III
H0S58_RS06925	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S58_RS06935	COG0360	Binds together with S18 to 16S ribosomal RNA
H0S58_RS06950	COG0305	Participates in initiation and elongation during chromosome replication
H0S58_RS06955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S58_RS06965	COG1305	Transglutaminase-like
H0S58_RS06975	COG2308	Evidence 4 Homologs of previously reported genes of
H0S58_RS06985	COG0069	glutamate synthase activity
H0S58_RS07005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S58_RS07010	COG1454	alcohol dehydrogenase
H0S58_RS07025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S58_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS07070	COG0583	DNA-binding transcription factor activity
H0S58_RS07075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S58_RS07090	COG3135	benzoate transporter
H0S58_RS07095	COG2076	Multidrug Resistance protein
H0S58_RS07100	COG0589	response to stress
H0S58_RS07105	COG0589	response to stress
H0S58_RS07120	COG0308	aminopeptidase N
H0S58_RS07145	COG1253	flavin adenine dinucleotide binding
H0S58_RS07165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S58_RS07170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S58_RS07175	COG2431	L-lysine efflux transmembrane transporter activity
H0S58_RS07180	COG0284	orotidine-5'-phosphate decarboxylase activity
H0S58_RS07190	COG0776	regulation of translation
H0S58_RS07220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0S58_RS07250	COG1309	transcriptional regulator
H0S58_RS07255	COG0084	hydrolase, TatD family'
H0S58_RS07275	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S58_RS07280	COG1132	(ABC) transporter
H0S58_RS07290	COG0811	peptide transport
H0S58_RS07295	COG1475	DNA binding
H0S58_RS07300	COG1192	Involved in chromosome partitioning
H0S58_RS07310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S58_RS07325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S58_RS07330	COG1923	regulation of RNA biosynthetic process
H0S58_RS07340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S58_RS07345	COG0802	atpase or kinase
H0S58_RS07370	COG2707	UPF0756 membrane protein
H0S58_RS07380	COG0583	DNA-binding transcription factor activity
H0S58_RS07385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S58_RS07400	COG1643	Atp-dependent helicase
H0S58_RS07425	COG3634	alkyl hydroperoxide reductase activity
H0S58_RS07440	COG2391	methyltransferase activity
H0S58_RS07470	COG2070	2-Nitropropane dioxygenase
H0S58_RS07500	COG0798	PFAM Bile acid sodium symporter
H0S58_RS07510	COG0640	Transcriptional regulator
H0S58_RS07540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0S58_RS07555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S58_RS07560	COG1301	dicarboxylic acid transport
H0S58_RS07565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S58_RS07570	COG2207	Transcriptional regulator
H0S58_RS07575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S58_RS07590	COG0730	response to heat
H0S58_RS07640	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS07645	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS07655	COG0693	protein deglycase activity
H0S58_RS07660	COG0739	heme binding
H0S58_RS07660	COG0741	lytic transglycosylase activity
H0S58_RS07660	COG1196	nuclear chromosome segregation
H0S58_RS07700	COG0552	protein localization to endoplasmic reticulum
H0S58_RS07705	COG0612	Peptidase, M16
H0S58_RS07730	COG0517	IMP dehydrogenase activity
H0S58_RS07730	COG0516	GMP reductase activity
H0S58_RS07740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S58_RS07755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H0S58_RS07760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S58_RS07795	COG0537	adenosine 5'-monophosphoramidase activity
H0S58_RS07805	COG0772	Belongs to the SEDS family
H0S58_RS07820	COG0148	phosphopyruvate hydratase activity
H0S58_RS07845	COG0372	Belongs to the citrate synthase family
H0S58_RS07870	COG0542	response to heat
H0S58_RS07875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S58_RS07895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0S58_RS07900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S58_RS07910	COG0569	domain protein
H0S58_RS07915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S58_RS07935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S58_RS07965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S58_RS07970	COG0776	regulation of translation
H0S58_RS07995	COG0822	iron-sulfur transferase activity
H0S58_RS08000	COG0316	Belongs to the HesB IscA family
H0S58_RS08030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S58_RS08060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S58_RS08080	COG0697	spore germination
H0S58_RS08095	COG0126	phosphoglycerate kinase activity
H0S58_RS08105	COG0424	maF-like protein
H0S58_RS08110	COG2850	peptidyl-arginine hydroxylation
H0S58_RS08120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S58_RS08125	COG0702	epimerase
H0S58_RS08140	COG1218	3'(2'),5'-bisphosphate nucleotidase
H0S58_RS08145	COG1011	Hydrolase
H0S58_RS08150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S58_RS08155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0S58_RS08160	COG2137	regulation of response to DNA damage stimulus
H0S58_RS08175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S58_RS08195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S58_RS08210	COG0575	Belongs to the CDS family
H0S58_RS08215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S58_RS08220	COG0233	cytoplasmic translational termination
H0S58_RS08235	COG3852	Histidine kinase
H0S58_RS08240	COG2204	response regulator
H0S58_RS08275	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S58_RS08280	COG0138	bifunctional purine biosynthesis protein purh
H0S58_RS08285	COG0151	Belongs to the GarS family
H0S58_RS08295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S58_RS08300	COG2011	ABC-type metal ion transport system permease component
H0S58_RS08340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S58_RS08350	COG4122	O-methyltransferase activity
H0S58_RS08355	COG0589	response to stress
H0S58_RS08385	COG1137	ATPase activity
H0S58_RS08390	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S58_RS08400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S58_RS08405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S58_RS08405	COG0517	IMP dehydrogenase activity
H0S58_RS08450	COG0625	glutathione transferase activity
H0S58_RS08465	COG0314	molybdopterin synthase activity
H0S58_RS08475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S58_RS08485	COG0243	molybdopterin cofactor binding
H0S58_RS08490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S58_RS08495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S58_RS08500	COG2223	nitrite transmembrane transporter activity
H0S58_RS08510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S58_RS08510	COG1116	anion transmembrane transporter activity
H0S58_RS08535	COG0519	Catalyzes the synthesis of GMP from XMP
H0S58_RS08535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S58_RS08540	COG1280	lysine exporter protein (LysE YggA)
H0S58_RS08565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S58_RS08570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0S58_RS08610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S58_RS08610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S58_RS08670	COG1522	sequence-specific DNA binding
H0S58_RS08680	COG0012	GTP binding
H0S58_RS08690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S58_RS08700	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S58_RS08725	COG0386	Belongs to the glutathione peroxidase family
H0S58_RS08730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S58_RS08735	COG0436	Aminotransferase
H0S58_RS08755	COG1187	pseudouridine synthase activity
H0S58_RS08770	COG1686	Belongs to the peptidase S11 family
H0S58_RS08775	COG1252	NADH dehydrogenase
H0S58_RS08785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S58_RS08825	COG1131	(ABC) transporter
H0S58_RS08830	COG0842	Transport permease protein
H0S58_RS08845	COG2951	lytic endotransglycosylase activity
H0S58_RS08870	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S58_RS08880	COG0436	Aminotransferase
H0S58_RS08900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S58_RS08905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S58_RS08910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S58_RS08945	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S58_RS08955	COG1012	belongs to the aldehyde dehydrogenase family
H0S58_RS08960	COG0174	glutamine synthetase
H0S58_RS08965	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S58_RS08970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S58_RS08980	COG2840	Smr protein MutS2
H0S58_RS08985	COG0302	gtp cyclohydrolase
H0S58_RS09005	COG3739	integral membrane protein
H0S58_RS09010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H0S58_RS09020	COG1741	Belongs to the pirin family
H0S58_RS09045	COG1902	pentaerythritol trinitrate reductase activity
H0S58_RS09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S58_RS09050	COG0277	FAD linked oxidase domain protein
H0S58_RS09060	COG2186	Transcriptional regulator
H0S58_RS09065	COG1620	l-lactate permease
H0S58_RS09075	COG5001	Diguanylate cyclase
H0S58_RS09075	COG2203	Gaf domain
H0S58_RS09075	COG3706	GGDEF domain
H0S58_RS09075	COG4251	negative regulation of phosphorylation
H0S58_RS09080	COG0418	dihydroorotase activity
H0S58_RS09085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S58_RS09100	COG0833	amino acid
H0S58_RS09125	COG4172	Belongs to the ABC transporter superfamily
H0S58_RS09130	COG4239	(ABC) transporter, permease
H0S58_RS09135	COG4174	ABC transporter (Permease)
H0S58_RS09140	COG4166	transmembrane transport
H0S58_RS09145	COG0741	lytic transglycosylase activity
H0S58_RS09145	COG1388	LysM domain
H0S58_RS09150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S58_RS09165	COG0657	acetylesterase activity
H0S58_RS09190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S58_RS09195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S58_RS09200	COG0006	proline dipeptidase activity
H0S58_RS09245	COG1203	CRISPR-associated helicase, Cas3
H0S58_RS09250	COG1518	maintenance of DNA repeat elements
H0S58_RS09265	COG0281	malic enzyme
H0S58_RS09270	COG2217	Heavy metal translocating P-type atpase
H0S58_RS09280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S58_RS09290	COG2234	aminopeptidase activity
H0S58_RS09300	COG3384	dioxygenase
H0S58_RS09310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S58_RS09315	COG2878	Part of a membrane complex involved in electron transport
H0S58_RS09320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S58_RS09345	COG0768	penicillin binding
H0S58_RS09350	COG0742	ribosomal rna small subunit methyltransferase
H0S58_RS09370	COG3015	lipoprotein NlpE involved in copper resistance
H0S58_RS09395	COG1597	lipid kinase activity
H0S58_RS09400	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H0S58_RS09415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S58_RS09425	COG2264	protein methyltransferase activity
H0S58_RS09455	COG0604	alcohol dehydrogenase
H0S58_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS09455	COG3321	synthase
H0S58_RS09470	COG0175	sulfate reduction
H0S58_RS09475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0S58_RS09485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S58_RS09500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S58_RS09505	COG1053	succinate dehydrogenase
H0S58_RS09510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S58_RS09515	COG2009	succinate dehydrogenase
H0S58_RS09525	COG2072	flavoprotein involved in K transport
H0S58_RS09530	COG0300	oxidoreductase activity
H0S58_RS09575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S58_RS09580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0S58_RS09610	COG0358	DNA primase activity
H0S58_RS09655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S58_RS09660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0S58_RS09680	COG1054	Belongs to the UPF0176 family
H0S58_RS09685	COG0586	Pfam SNARE associated Golgi protein
H0S58_RS09705	COG2921	Belongs to the UPF0250 family
H0S58_RS09710	COG0321	lipoyl(octanoyl) transferase activity
H0S58_RS09725	COG0531	amino acid
H0S58_RS09730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S58_RS09735	COG1648	precorrin-2 dehydrogenase activity
H0S58_RS09735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S58_RS09760	COG1649	PFAM Uncharacterised BCR, COG1649
H0S58_RS09760	COG0726	polysaccharide deacetylase
H0S58_RS09770	COG1215	transferase activity, transferring glycosyl groups
H0S58_RS09775	COG1649	PFAM Uncharacterised BCR, COG1649
H0S58_RS09775	COG0726	polysaccharide deacetylase
H0S58_RS09810	COG3706	GGDEF domain
H0S58_RS09810	COG2203	Gaf domain
H0S58_RS09810	COG5001	Diguanylate cyclase
H0S58_RS09810	COG4251	negative regulation of phosphorylation
H0S58_RS09825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S58_RS09850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0S58_RS09865	COG0671	phosphoesterase, PA-phosphatase related
H0S58_RS09870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S58_RS09880	COG1538	Outer membrane efflux protein
H0S58_RS09885	COG0393	Putative heavy-metal-binding
H0S58_RS09895	COG4221	oxidoreductase activity
H0S58_RS09905	COG0525	valine-tRNA ligase activity
H0S58_RS09930	COG2323	membrane
H0S58_RS09940	COG0765	amino acid transport
H0S58_RS09945	COG0765	amino acid transport
H0S58_RS09950	COG1126	abc transporter atp-binding protein
H0S58_RS09955	COG0004	ammonium transporteR
H0S58_RS09965	COG0642	Histidine kinase
H0S58_RS09970	COG0745	RESPONSE REGULATOR receiver
H0S58_RS09975	COG2194	sulfuric ester hydrolase activity
H0S58_RS09995	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S58_RS10010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S58_RS10015	COG0142	geranyltranstransferase activity
H0S58_RS10020	COG2828	Protein conserved in bacteria
H0S58_RS10025	COG1113	amino acid transport
H0S58_RS10035	COG0582	viral genome integration into host DNA
H0S58_RS10040	COG3177	Filamentation induced by cAMP protein fic
H0S58_RS10070	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0S58_RS10080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H0S58_RS10080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H0S58_RS10135	COG0477	Major facilitator Superfamily
H0S58_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS10145	COG0371	Dehydrogenase
H0S58_RS10165	COG0583	DNA-binding transcription factor activity
H0S58_RS10180	COG1278	Cold shock
H0S58_RS10245	COG0642	Histidine kinase
H0S58_RS10260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0S58_RS10305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S58_RS10320	COG0424	maF-like protein
H0S58_RS10330	COG1792	Involved in formation and maintenance of cell shape
H0S58_RS10335	COG1077	Cell shape determining protein MreB Mrl
H0S58_RS10340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S58_RS10350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S58_RS10395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0S58_RS10410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S58_RS10410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S58_RS10450	COG0420	3'-5' exonuclease activity
H0S58_RS10475	COG0735	belongs to the Fur family
H0S58_RS10480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S58_RS10485	COG2914	Belongs to the UPF0125 (RnfH) family
H0S58_RS10500	COG0121	glutamine amidotransferase
H0S58_RS10510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S58_RS10515	COG0756	dUTP diphosphatase activity
H0S58_RS10525	COG2885	chlorophyll binding
H0S58_RS10530	COG0204	Acyl-transferase
H0S58_RS10540	COG0850	regulation of cytokinetic process
H0S58_RS10550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H0S58_RS10565	COG0531	amino acid
H0S58_RS10565	COG1674	ftsk spoiiie
H0S58_RS10570	COG0492	ferredoxin-NADP+ reductase activity
H0S58_RS10575	COG0500	methyltransferase
H0S58_RS10580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S58_RS10590	COG0456	acetyltransferase
H0S58_RS10615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S58_RS10630	COG1981	membrane
H0S58_RS10640	COG0352	thiamine-phosphate diphosphorylase activity
H0S58_RS10640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S58_RS10640	COG0351	phosphomethylpyrimidine kinase
H0S58_RS10650	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S58_RS10665	COG0564	pseudouridine synthase activity
H0S58_RS10670	COG0477	Major facilitator Superfamily
H0S58_RS10685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0S58_RS10690	COG0354	folic acid binding
H0S58_RS10705	COG0679	Auxin Efflux Carrier
H0S58_RS10715	COG4772	TonB-dependent receptor
H0S58_RS10725	COG1272	protein, Hemolysin III
H0S58_RS10730	COG0477	Major facilitator Superfamily
H0S58_RS10735	COG1408	metallophosphoesterase
H0S58_RS10740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S58_RS10750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S58_RS10775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S58_RS10780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S58_RS10785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0S58_RS10790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S58_RS10795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S58_RS10800	COG0625	glutathione transferase activity
H0S58_RS10805	COG2969	positive regulation of protein catabolic process
H0S58_RS10875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S58_RS10880	COG1764	response to oxidative stress
H0S58_RS10920	COG0037	tRNA processing
H0S58_RS10930	COG0248	Ppx GppA phosphatase
H0S58_RS10955	COG0072	phenylalanine-tRNA ligase activity
H0S58_RS10960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0S58_RS10975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S58_RS10980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S58_RS10985	COG1162	GTPase activity
H0S58_RS10995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S58_RS11000	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H0S58_RS11015	COG0084	hydrolase, TatD family'
H0S58_RS11030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S58_RS11055	COG2184	nucleotidyltransferase activity
H0S58_RS11105	COG0793	Belongs to the peptidase S41A family
H0S58_RS11120	COG2267	carboxylic ester hydrolase activity
H0S58_RS11135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S58_RS11140	COG0857	belongs to the CobB CobQ family
H0S58_RS11140	COG0280	phosphate acetyltransferase
H0S58_RS11145	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S58_RS11165	COG0740	serine-type endopeptidase activity
H0S58_RS11175	COG4771	TonB-dependent receptor
H0S58_RS11180	COG4774	siderophore transport
H0S58_RS11190	COG4774	siderophore transport
H0S58_RS11195	COG3128	pkhd-type hydroxylase
H0S58_RS11205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S58_RS11210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S58_RS11215	COG2813	Specifically methylates the guanine in position
H0S58_RS11215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S58_RS11295	COG1238	metal cluster binding
H0S58_RS11305	COG0625	glutathione transferase activity
H0S58_RS11320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0S58_RS11330	COG0318	PFAM AMP-dependent synthetase and ligase
H0S58_RS11335	COG3028	Belongs to the UPF0307 family
H0S58_RS11340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S58_RS11345	COG1660	Displays ATPase and GTPase activities
H0S58_RS11350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0S58_RS11360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S58_RS11365	COG0617	tRNA 3'-terminal CCA addition
H0S58_RS11370	COG1596	polysaccharide export
H0S58_RS11370	COG1555	photosystem II stabilization
H0S58_RS11390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S58_RS11410	COG1426	Protein conserved in bacteria
H0S58_RS11485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0S58_RS11490	COG0440	acetolactate synthase activity
H0S58_RS11495	COG0028	Belongs to the TPP enzyme family
H0S58_RS11520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S58_RS11525	COG1136	(ABC) transporter
H0S58_RS11525	COG0577	efflux transmembrane transporter activity
H0S58_RS11530	COG1538	Outer membrane efflux protein
H0S58_RS11540	COG3293	Transposase
H0S58_RS11585	COG0788	formyltetrahydrofolate deformylase activity
H0S58_RS11610	COG4651	solute:proton antiporter activity
H0S58_RS11610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S58_RS11635	COG0210	DNA helicase
H0S58_RS11640	COG1929	Belongs to the glycerate kinase type-1 family
H0S58_RS11670	COG2900	Belongs to the SlyX family
H0S58_RS11675	COG0488	(ABC) transporter
H0S58_RS11680	COG1560	Kdo2-lipid A biosynthetic process
H0S58_RS11740	COG0473	3-isopropylmalate dehydrogenase activity
H0S58_RS11755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0S58_RS11770	COG0583	DNA-binding transcription factor activity
H0S58_RS11800	COG1960	acyl-CoA dehydrogenase activity
H0S58_RS11810	COG0753	catalase activity
H0S58_RS11825	COG0583	DNA-binding transcription factor activity
H0S58_RS11835	COG0564	pseudouridine synthase activity
H0S58_RS11840	COG1530	ribonuclease E activity
H0S58_RS11845	COG0318	PFAM AMP-dependent synthetase and ligase
H0S58_RS11875	COG1983	PspC domain protein
H0S58_RS11890	COG0751	glycine-tRNA ligase activity
H0S58_RS11915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0S58_RS11930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0S58_RS11945	COG0493	'glutamate synthase
H0S58_RS11955	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S58_RS11960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S58_RS11975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S58_RS11985	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S58_RS11985	COG0644	oxidoreductase
H0S58_RS11990	COG0425	Belongs to the sulfur carrier protein TusA family
H0S58_RS11995	COG4535	Mg2 and Co2 transporter CorC
H0S58_RS12000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0S58_RS12020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S58_RS12030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0S58_RS12035	COG2203	Gaf domain
H0S58_RS12035	COG2199	diguanylate cyclase activity
H0S58_RS12040	COG0484	heat shock protein binding
H0S58_RS12045	COG0789	Transcriptional regulator
H0S58_RS12055	COG0598	Magnesium transport protein CorA
H0S58_RS12060	COG1185	polyribonucleotide nucleotidyltransferase activity
H0S58_RS12070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S58_RS12075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S58_RS12080	COG1074	ATP-dependent DNA helicase activity
H0S58_RS12085	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S58_RS12115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S58_RS12125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S58_RS12135	COG2111	Na H antiporter
H0S58_RS12135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S58_RS12140	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S58_RS12145	COG0651	ATP synthesis coupled electron transport
H0S58_RS12155	COG2212	antiporter activity
H0S58_RS12160	COG1320	monovalent cation:proton antiporter activity
H0S58_RS12165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0S58_RS12170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0S58_RS12175	COG0195	Participates in both transcription termination and antitermination
H0S58_RS12180	COG0779	Required for maturation of 30S ribosomal subunits
H0S58_RS12230	COG0237	dephospho-CoA kinase activity
H0S58_RS12240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S58_RS12245	COG3123	guanosine phosphorylase activity
H0S58_RS12250	COG0497	DNA recombination
H0S58_RS12260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S58_RS12275	COG1289	transmembrane transporter activity
H0S58_RS12290	COG1132	(ABC) transporter
H0S58_RS12300	COG1538	Outer membrane efflux protein
H0S58_RS12315	COG0494	nUDIX hydrolase
H0S58_RS12320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S58_RS12325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S58_RS12330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S58_RS12340	COG0772	Belongs to the SEDS family
H0S58_RS12365	COG4974	Belongs to the 'phage' integrase family
H0S58_RS12370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S58_RS12380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S58_RS12385	COG1686	Belongs to the peptidase S11 family
H0S58_RS12390	COG2197	response regulator
H0S58_RS12405	COG0793	Belongs to the peptidase S41A family
H0S58_RS12410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S58_RS12415	COG0795	lipopolysaccharide-transporting ATPase activity
H0S58_RS12420	COG0795	lipopolysaccharide-transporting ATPase activity
H0S58_RS12440	COG0586	Pfam SNARE associated Golgi protein
H0S58_RS12455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S58_RS12455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S58_RS12465	COG0004	ammonium transporteR
H0S58_RS12470	COG0347	Belongs to the P(II) protein family
H0S58_RS12480	COG0606	chelatase, subunit chli
H0S58_RS12495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S58_RS12510	COG0318	PFAM AMP-dependent synthetase and ligase
H0S58_RS12520	COG0477	Major facilitator Superfamily
H0S58_RS12525	COG2860	membrane
H0S58_RS12535	COG1253	flavin adenine dinucleotide binding
H0S58_RS12555	COG2814	Major facilitator Superfamily
H0S58_RS12565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S58_RS12585	COG2814	Major facilitator Superfamily
H0S58_RS12615	COG1309	transcriptional regulator
H0S58_RS12645	COG0758	DNA mediated transformation
H0S58_RS12655	COG0697	spore germination
H0S58_RS12670	COG0386	Belongs to the glutathione peroxidase family
H0S58_RS12710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H0S58_RS12750	COG1121	(ABC) transporter
H0S58_RS12755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S58_RS12765	COG2837	iron assimilation
H0S58_RS12770	COG0436	Aminotransferase
H0S58_RS12775	COG0534	Mate efflux family protein
H0S58_RS12780	COG1116	anion transmembrane transporter activity
H0S58_RS12785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S58_RS12790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S58_RS12860	COG0519	Catalyzes the synthesis of GMP from XMP
H0S58_RS12860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S58_RS12875	COG0586	Pfam SNARE associated Golgi protein
H0S58_RS12890	COG1192	Involved in chromosome partitioning
H0S58_RS12900	COG0271	Belongs to the BolA IbaG family
H0S58_RS12935	COG3756	Protein conserved in bacteria
H0S58_RS13025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S58_RS13030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0S58_RS13120	COG3550	peptidyl-serine autophosphorylation
H0S58_RS13125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0S58_RS13180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S58_RS13185	COG2814	Major facilitator Superfamily
H0S58_RS13200	COG2223	nitrite transmembrane transporter activity
H0S58_RS13230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0S58_RS13235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0S58_RS13240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S58_RS13245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S58_RS13250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0S58_RS13255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S58_RS13270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0S58_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
H0S58_RS13315	COG2986	histidine ammonia-lyase
H0S58_RS13330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0S58_RS13340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S58_RS13360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S58_RS13365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S58_RS13380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S58_RS13390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0S58_RS13400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S58_RS13420	COG1215	transferase activity, transferring glycosyl groups
H0S58_RS13445	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0S58_RS13455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S58_RS13460	COG1596	polysaccharide export
H0S58_RS13485	COG0400	carboxylic ester hydrolase activity
H0S58_RS13510	COG2818	Glycosylase
H0S58_RS13515	COG1064	alcohol dehydrogenase
H0S58_RS13520	COG0583	DNA-binding transcription factor activity
H0S58_RS13555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S58_RS13560	COG1309	transcriptional regulator
H0S58_RS13575	COG2233	PERMEase
H0S58_RS13580	COG0583	DNA-binding transcription factor activity
H0S58_RS13600	COG0129	dihydroxy-acid dehydratase activity
H0S58_RS13605	COG3385	transposase activity
H0S58_RS13625	COG0428	transporter
H0S58_RS13635	COG0733	neurotransmitter:sodium symporter activity
H0S58_RS13675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S58_RS13680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S58_RS13685	COG2951	lytic endotransglycosylase activity
H0S58_RS13690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S58_RS13705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S58_RS13710	COG2388	GCN5-related N-acetyl-transferase
H0S58_RS13720	COG0861	Integral membrane protein TerC family
H0S58_RS13725	COG0402	S-adenosylhomocysteine deaminase activity
H0S58_RS13755	COG0706	membrane insertase activity
H0S58_RS13760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0S58_RS13765	COG0594	ribonuclease P activity