locus-tag	class	description
M5E07_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5E07_RS00020	COG0187	DNA topoisomerase II activity
M5E07_RS00030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5E07_RS00035	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M5E07_RS00060	COG0488	(ABC) transporter
M5E07_RS00090	COG2814	Major facilitator Superfamily
M5E07_RS00095	COG2133	pyrroloquinoline quinone binding
M5E07_RS00110	COG2233	PERMEase
M5E07_RS00125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_RS00150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5E07_RS00160	COG2814	Major facilitator Superfamily
M5E07_RS00165	COG0656	L-ascorbic acid biosynthetic process
M5E07_RS00170	COG0583	DNA-binding transcription factor activity
M5E07_RS00180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E07_RS00185	COG1064	alcohol dehydrogenase
M5E07_RS00190	COG2818	Glycosylase
M5E07_RS00205	COG1194	a g-specific adenine glycosylase
M5E07_RS00220	COG5487	UPF0391 membrane protein
M5E07_RS00225	COG2983	Belongs to the UPF0260 family
M5E07_RS00230	COG2819	hydrolase of the alpha beta superfamily
M5E07_RS00235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5E07_RS00245	COG4160	amino acid transport
M5E07_RS00250	COG4215	(ABC) transporter
M5E07_RS00265	COG1522	sequence-specific DNA binding
M5E07_RS00270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5E07_RS00280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E07_RS00285	COG2814	Major facilitator Superfamily
M5E07_RS00290	COG1335	isochorismatase
M5E07_RS00295	COG0385	Bile acid
M5E07_RS00310	COG0560	Phosphoserine phosphatase
M5E07_RS00310	COG3830	Belongs to the UPF0237 family
M5E07_RS00365	COG0534	Mate efflux family protein
M5E07_RS00370	COG0436	Aminotransferase
M5E07_RS00375	COG2733	membrane
M5E07_RS00390	COG2918	glutathione biosynthetic process
M5E07_RS00395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5E07_RS00405	COG3150	esterase
M5E07_RS00480	COG3706	GGDEF domain
M5E07_RS00485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5E07_RS00505	COG0708	Exodeoxyribonuclease III
M5E07_RS00510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5E07_RS00545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5E07_RS00555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5E07_RS00565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5E07_RS00590	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E07_RS00600	COG2119	membrane
M5E07_RS00605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_RS00605	COG0426	domain, Protein
M5E07_RS00615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E07_RS00625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5E07_RS00650	COG1902	pentaerythritol trinitrate reductase activity
M5E07_RS00655	COG1519	Transferase
M5E07_RS00660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5E07_RS00665	COG0668	transmembrane transport
M5E07_RS00675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E07_RS00690	COG0431	NADPH-dependent FMN reductase
M5E07_RS00705	COG2198	Histidine kinase
M5E07_RS00705	COG2205	protein histidine kinase activity
M5E07_RS00705	COG0784	Response regulator, receiver
M5E07_RS00710	COG3162	membrane
M5E07_RS00725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5E07_RS00740	COG3706	GGDEF domain
M5E07_RS00755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5E07_RS00760	COG1309	transcriptional regulator
M5E07_RS00780	COG0300	oxidoreductase activity
M5E07_RS00785	COG0789	Transcriptional regulator
M5E07_RS00790	COG0351	phosphomethylpyrimidine kinase
M5E07_RS00790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E07_RS00790	COG0352	thiamine-phosphate diphosphorylase activity
M5E07_RS00800	COG2814	Major facilitator Superfamily
M5E07_RS00805	COG0629	single-stranded DNA binding
M5E07_RS00810	COG1113	amino acid transport
M5E07_RS00820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5E07_RS00825	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_RS00840	COG1335	isochorismatase
M5E07_RS00850	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M5E07_RS00870	COG2814	Major facilitator Superfamily
M5E07_RS00875	COG0583	DNA-binding transcription factor activity
M5E07_RS00900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E07_RS00905	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS00910	COG1024	Enoyl-CoA hydratase
M5E07_RS00950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5E07_RS00970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E07_RS00990	COG0531	amino acid
M5E07_RS00995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5E07_RS01015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M5E07_RS01020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5E07_RS01055	COG0427	acetyl-CoA hydrolase
M5E07_RS01085	COG4221	oxidoreductase activity
M5E07_RS01090	COG2873	o-acetylhomoserine
M5E07_RS01095	COG0488	(ABC) transporter
M5E07_RS01160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M5E07_RS01180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M5E07_RS01185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5E07_RS01195	COG2226	methyltransferase
M5E07_RS01245	COG0067	glutamate synthase
M5E07_RS01245	COG0069	glutamate synthase activity
M5E07_RS01245	COG0070	glutamate synthase
M5E07_RS01250	COG0493	'glutamate synthase
M5E07_RS01260	COG1704	LemA family
M5E07_RS01265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M5E07_RS01275	COG4969	Belongs to the N-Me-Phe pilin family
M5E07_RS01280	COG4969	Belongs to the N-Me-Phe pilin family
M5E07_RS01290	COG3307	-O-antigen
M5E07_RS01310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5E07_RS01315	COG1758	RNA polymerase activity
M5E07_RS01320	COG0194	GDP metabolic process
M5E07_RS01365	COG0228	four-way junction DNA binding
M5E07_RS01370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5E07_RS01380	COG0335	large ribosomal subunit rRNA binding
M5E07_RS01385	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5E07_RS01390	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5E07_RS01395	COG5380	lipid catabolic process
M5E07_RS01400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5E07_RS01420	COG5006	permease, DMT superfamily
M5E07_RS01425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5E07_RS01430	COG0277	FAD linked oxidase domain protein
M5E07_RS01455	COG2814	Major facilitator Superfamily
M5E07_RS01465	COG2032	superoxide dismutase activity
M5E07_RS01470	COG0628	permease
M5E07_RS01475	COG1192	Involved in chromosome partitioning
M5E07_RS01500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E07_RS01510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5E07_RS01515	COG0534	Mate efflux family protein
M5E07_RS01525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E07_RS01535	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS01555	COG0408	coproporphyrinogen oxidase activity
M5E07_RS01560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E07_RS01570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5E07_RS01580	COG0513	Belongs to the DEAD box helicase family
M5E07_RS01585	COG1127	ABC transporter
M5E07_RS01590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M5E07_RS01595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M5E07_RS01610	COG0598	Magnesium transport protein CorA
M5E07_RS01620	COG2816	NAD+ diphosphatase activity
M5E07_RS01625	COG1040	competence protein
M5E07_RS01630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5E07_RS01675	COG2937	Belongs to the GPAT DAPAT family
M5E07_RS01680	COG1946	Acyl-CoA thioesterase
M5E07_RS01690	COG1301	dicarboxylic acid transport
M5E07_RS01710	COG1959	2 iron, 2 sulfur cluster binding
M5E07_RS01720	COG0433	COG0433 Predicted ATPase
M5E07_RS01725	COG0626	cystathionine gamma-synthase activity
M5E07_RS01745	COG0088	Forms part of the polypeptide exit tunnel
M5E07_RS01750	COG0089	rRNA binding
M5E07_RS01760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5E07_RS01810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5E07_RS01815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5E07_RS01825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M5E07_RS01850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5E07_RS01860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M5E07_RS01865	COG0202	RNA polymerase activity
M5E07_RS01870	COG0203	ribosomal protein L17
M5E07_RS01875	COG2072	flavoprotein involved in K transport
M5E07_RS01880	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS01885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M5E07_RS01915	COG0697	spore germination
M5E07_RS01930	COG0339	signal peptide processing
M5E07_RS01940	COG0557	exoribonuclease II activity
M5E07_RS01975	COG0179	Fumarylacetoacetate (FAA) hydrolase
M5E07_RS02005	COG1295	ribonuclease BN
M5E07_RS02045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5E07_RS02050	COG1702	phosphate starvation-inducible protein PhoH
M5E07_RS02055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E07_RS02060	COG1196	nuclear chromosome segregation
M5E07_RS02060	COG0741	lytic transglycosylase activity
M5E07_RS02060	COG0739	heme binding
M5E07_RS02095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M5E07_RS02100	COG1183	phosphatidylcholine synthase activity
M5E07_RS02140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_RS02170	COG1607	acyl-coa hydrolase
M5E07_RS02180	COG1666	GTP binding
M5E07_RS02200	COG2350	Protein conserved in bacteria
M5E07_RS02215	COG0625	glutathione transferase activity
M5E07_RS02220	COG3781	membrane
M5E07_RS02225	COG2003	Belongs to the UPF0758 family
M5E07_RS02230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E07_RS02235	COG3783	Cytochrome b(562)
M5E07_RS02265	COG1162	GTPase activity
M5E07_RS02270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M5E07_RS02285	COG1538	Outer membrane efflux protein
M5E07_RS02290	COG0577	efflux transmembrane transporter activity
M5E07_RS02290	COG1136	(ABC) transporter
M5E07_RS02295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_RS02320	COG0028	Belongs to the TPP enzyme family
M5E07_RS02325	COG0440	acetolactate synthase activity
M5E07_RS02430	COG1862	Preprotein translocase
M5E07_RS02440	COG4251	negative regulation of phosphorylation
M5E07_RS02440	COG5001	Diguanylate cyclase
M5E07_RS02440	COG2203	Gaf domain
M5E07_RS02440	COG3706	GGDEF domain
M5E07_RS02445	COG1704	LemA family
M5E07_RS02455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M5E07_RS02525	COG1113	amino acid transport
M5E07_RS02535	COG0625	glutathione transferase activity
M5E07_RS02555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E07_RS02560	COG1522	sequence-specific DNA binding
M5E07_RS02565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M5E07_RS02580	COG0084	hydrolase, TatD family'
M5E07_RS02595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5E07_RS02605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E07_RS02630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E07_RS02640	COG1335	isochorismatase
M5E07_RS02650	COG0640	Transcriptional regulator
M5E07_RS02660	COG0798	PFAM Bile acid sodium symporter
M5E07_RS02665	COG0431	NADPH-dependent FMN reductase
M5E07_RS02680	COG2814	Major facilitator Superfamily
M5E07_RS02690	COG0789	Transcriptional regulator
M5E07_RS02695	COG0697	spore germination
M5E07_RS02720	COG0004	ammonium transporteR
M5E07_RS02735	COG3622	Belongs to the hyi family
M5E07_RS02740	COG2084	Dehydrogenase
M5E07_RS02745	COG1024	Enoyl-CoA hydratase
M5E07_RS02750	COG5002	protein histidine kinase activity
M5E07_RS02750	COG0784	Response regulator, receiver
M5E07_RS02750	COG2205	protein histidine kinase activity
M5E07_RS02755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E07_RS02770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5E07_RS02775	COG3956	TIGRFAM MazG family protein
M5E07_RS02780	COG1555	photosystem II stabilization
M5E07_RS02790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5E07_RS02805	COG1660	Displays ATPase and GTPase activities
M5E07_RS02815	COG3028	Belongs to the UPF0307 family
M5E07_RS02820	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_RS02830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M5E07_RS02840	COG0625	glutathione transferase activity
M5E07_RS02850	COG1238	metal cluster binding
M5E07_RS02890	COG0072	phenylalanine-tRNA ligase activity
M5E07_RS02915	COG0248	Ppx GppA phosphatase
M5E07_RS02925	COG0037	tRNA processing
M5E07_RS02970	COG1764	response to oxidative stress
M5E07_RS02975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E07_RS03040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5E07_RS03050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5E07_RS03110	COG1214	PFAM Peptidase M22, glycoprotease
M5E07_RS03115	COG1968	undecaprenyl-diphosphatase activity
M5E07_RS03195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E07_RS03205	COG2132	Multicopper oxidase
M5E07_RS03235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E07_RS03235	COG0352	thiamine-phosphate diphosphorylase activity
M5E07_RS03235	COG0351	phosphomethylpyrimidine kinase
M5E07_RS03265	COG0251	oxidation-reduction process
M5E07_RS03270	COG1113	amino acid transport
M5E07_RS03280	COG1981	membrane
M5E07_RS03295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M5E07_RS03305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5E07_RS03310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5E07_RS03320	COG0456	acetyltransferase
M5E07_RS03330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M5E07_RS03335	COG0492	ferredoxin-NADP+ reductase activity
M5E07_RS03340	COG1674	ftsk spoiiie
M5E07_RS03345	COG0583	DNA-binding transcription factor activity
M5E07_RS03360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M5E07_RS03365	COG2894	cell division
M5E07_RS03370	COG0850	regulation of cytokinetic process
M5E07_RS03380	COG0204	Acyl-transferase
M5E07_RS03385	COG2885	chlorophyll binding
M5E07_RS03390	COG0210	DNA helicase
M5E07_RS03395	COG0756	dUTP diphosphatase activity
M5E07_RS03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E07_RS03405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5E07_RS03415	COG0121	glutamine amidotransferase
M5E07_RS03430	COG2914	Belongs to the UPF0125 (RnfH) family
M5E07_RS03435	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5E07_RS03440	COG0735	belongs to the Fur family
M5E07_RS03450	COG0420	3'-5' exonuclease activity
M5E07_RS03465	COG1090	epimerase
M5E07_RS03480	COG2050	protein possibly involved in aromatic compounds catabolism
M5E07_RS03490	COG2814	Major facilitator Superfamily
M5E07_RS03495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5E07_RS03505	COG0582	viral genome integration into host DNA
M5E07_RS03595	COG3046	protein related to deoxyribodipyrimidine photolyase
M5E07_RS03600	COG2816	NAD+ diphosphatase activity
M5E07_RS03640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M5E07_RS03655	COG0642	Histidine kinase
M5E07_RS03660	COG0745	RESPONSE REGULATOR receiver
M5E07_RS03690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E07_RS03700	COG0583	DNA-binding transcription factor activity
M5E07_RS03710	COG3209	COG3209 Rhs family protein
M5E07_RS03730	COG1414	Transcriptional regulator
M5E07_RS03735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E07_RS03745	COG2814	Major facilitator Superfamily
M5E07_RS03750	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_RS03750	COG2030	dehydratase
M5E07_RS03755	COG3396	Phenylacetate-CoA oxygenase
M5E07_RS03760	COG3460	Phenylacetate-CoA oxygenase
M5E07_RS03765	COG3396	Phenylacetate-CoA oxygenase
M5E07_RS03770	COG2151	metal-sulfur cluster biosynthetic enzyme
M5E07_RS03775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E07_RS03780	COG1024	Enoyl-CoA hydratase
M5E07_RS03785	COG1024	Enoyl-CoA hydratase
M5E07_RS03790	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E07_RS03795	COG0183	Belongs to the thiolase family
M5E07_RS03800	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M5E07_RS03805	COG3327	negative regulation of DNA-templated transcription, initiation
M5E07_RS03825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E07_RS03825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E07_RS03850	COG0489	protein tyrosine kinase activity
M5E07_RS03890	COG0442	prolyl-tRNA aminoacylation
M5E07_RS03900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_RS03925	COG0840	transmembrane signaling receptor activity
M5E07_RS03940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E07_RS03955	COG2832	Protein of unknown function (DUF454)
M5E07_RS04015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E07_RS04025	COG1289	transmembrane transporter activity
M5E07_RS04030	COG2814	Major facilitator Superfamily
M5E07_RS04050	COG0589	response to stress
M5E07_RS04060	COG0110	maltose O-acetyltransferase activity
M5E07_RS04070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E07_RS04075	COG0505	Belongs to the CarA family
M5E07_RS04100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5E07_RS04105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5E07_RS04110	COG2304	oxidoreductase activity
M5E07_RS04160	COG0477	Major facilitator Superfamily
M5E07_RS04180	COG1597	lipid kinase activity
M5E07_RS04210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E07_RS04225	COG0741	lytic transglycosylase activity
M5E07_RS04230	COG0037	tRNA processing
M5E07_RS04240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M5E07_RS04245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5E07_RS04265	COG0583	DNA-binding transcription factor activity
M5E07_RS04300	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_RS04330	COG0006	proline dipeptidase activity
M5E07_RS04335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_RS04340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E07_RS04360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E07_RS04365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E07_RS04395	COG2816	NAD+ diphosphatase activity
M5E07_RS04405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5E07_RS04410	COG1388	LysM domain
M5E07_RS04410	COG0741	lytic transglycosylase activity
M5E07_RS04415	COG4166	transmembrane transport
M5E07_RS04420	COG4174	ABC transporter (Permease)
M5E07_RS04425	COG4239	(ABC) transporter, permease
M5E07_RS04430	COG4172	Belongs to the ABC transporter superfamily
M5E07_RS04510	COG0833	amino acid
M5E07_RS04530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5E07_RS04535	COG0418	dihydroorotase activity
M5E07_RS04550	COG2186	Transcriptional regulator
M5E07_RS04560	COG0277	FAD linked oxidase domain protein
M5E07_RS04565	COG1902	pentaerythritol trinitrate reductase activity
M5E07_RS04565	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E07_RS04595	COG1358	cellular component organization or biogenesis
M5E07_RS04635	COG2304	oxidoreductase activity
M5E07_RS04660	COG0242	peptide deformylase activity
M5E07_RS04670	COG2223	nitrite transmembrane transporter activity
M5E07_RS04685	COG2852	Protein conserved in bacteria
M5E07_RS04705	COG0306	phosphate transporter
M5E07_RS04715	COG1215	transferase activity, transferring glycosyl groups
M5E07_RS04720	COG0726	polysaccharide deacetylase
M5E07_RS04720	COG1649	PFAM Uncharacterised BCR, COG1649
M5E07_RS04725	COG0583	DNA-binding transcription factor activity
M5E07_RS04735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_RS04740	COG1773	rubredoxin
M5E07_RS04745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E07_RS04770	COG1741	Belongs to the pirin family
M5E07_RS04780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5E07_RS04785	COG3739	integral membrane protein
M5E07_RS04815	COG0302	gtp cyclohydrolase
M5E07_RS04830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M5E07_RS04835	COG0512	Glutamine amidotransferase of anthranilate synthase
M5E07_RS04840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5E07_RS04845	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E07_RS04860	COG0523	cobalamin synthesis protein
M5E07_RS04865	COG4681	YaeQ
M5E07_RS04875	COG2199	diguanylate cyclase activity
M5E07_RS04875	COG2203	Gaf domain
M5E07_RS04940	COG0288	reversible hydration of carbon dioxide
M5E07_RS04950	COG4181	ATPase activity
M5E07_RS04955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M5E07_RS04975	COG2197	response regulator
M5E07_RS05005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E07_RS05010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5E07_RS05020	COG0604	alcohol dehydrogenase
M5E07_RS05020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E07_RS05020	COG4221	oxidoreductase activity
M5E07_RS05020	COG3321	synthase
M5E07_RS05030	COG2851	Citrate transporter
M5E07_RS05035	COG1253	flavin adenine dinucleotide binding
M5E07_RS05070	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M5E07_RS05080	COG0281	malic enzyme
M5E07_RS05080	COG0280	phosphate acetyltransferase
M5E07_RS05090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5E07_RS05095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5E07_RS05100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M5E07_RS05130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5E07_RS05135	COG0778	Nitroreductase
M5E07_RS05140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5E07_RS05145	COG1051	belongs to the nudix hydrolase family
M5E07_RS05145	COG1056	cytidyltransferase-related domain
M5E07_RS05150	COG2353	YceI-like domain
M5E07_RS05155	COG0583	DNA-binding transcription factor activity
M5E07_RS05160	COG1279	arginine transmembrane transporter activity
M5E07_RS05165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5E07_RS05180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M5E07_RS05185	COG0602	queuosine metabolic process
M5E07_RS05205	COG0583	DNA-binding transcription factor activity
M5E07_RS05210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M5E07_RS05215	COG4208	sulfate ABC transporter
M5E07_RS05230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M5E07_RS05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E07_RS05240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E07_RS05260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E07_RS05270	COG0481	GTPase activity
M5E07_RS05275	COG0681	Belongs to the peptidase S26 family
M5E07_RS05285	COG0571	ribonuclease III activity
M5E07_RS05290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5E07_RS05305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M5E07_RS05345	COG0436	Aminotransferase
M5E07_RS05365	COG0556	nucleotide-excision repair
M5E07_RS05405	COG1733	regulation of RNA biosynthetic process
M5E07_RS05420	COG0671	phosphoesterase, PA-phosphatase related
M5E07_RS05430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5E07_RS05435	COG0076	glutamate decarboxylase activity
M5E07_RS05440	COG1522	sequence-specific DNA binding
M5E07_RS05445	COG3961	Belongs to the TPP enzyme family
M5E07_RS05450	COG1113	amino acid transport
M5E07_RS05455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5E07_RS05460	COG0573	inorganic phosphate transmembrane transporter activity
M5E07_RS05470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E07_RS05475	COG0616	signal peptide processing
M5E07_RS05520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5E07_RS05525	COG1686	Belongs to the peptidase S11 family
M5E07_RS05540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M5E07_RS05550	COG0583	DNA-binding transcription factor activity
M5E07_RS05555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E07_RS05560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M5E07_RS05585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E07_RS05590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E07_RS05600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5E07_RS05615	COG2986	histidine ammonia-lyase
M5E07_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS05660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E07_RS05675	COG2070	2-Nitropropane dioxygenase
M5E07_RS05710	COG1067	ATP-dependent peptidase activity
M5E07_RS05745	COG1509	lysine 2,3-aminomutase activity
M5E07_RS05750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5E07_RS05755	COG1966	Carbon starvation protein
M5E07_RS05760	COG2879	small protein
M5E07_RS05765	COG0714	Associated with various cellular activities
M5E07_RS05840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5E07_RS05920	COG4695	Portal protein
M5E07_RS06050	COG3549	Plasmid maintenance system killer
M5E07_RS06055	COG3093	addiction module antidote protein HigA
M5E07_RS06100	COG2252	PERMEase
M5E07_RS06105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M5E07_RS06110	COG3038	cytochrome b561
M5E07_RS06125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E07_RS06135	COG0527	aspartate kinase activity
M5E07_RS06145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E07_RS06165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5E07_RS06180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5E07_RS06195	COG0667	Aldo Keto reductase
M5E07_RS06205	COG1765	OsmC-like protein
M5E07_RS06210	COG0542	response to heat
M5E07_RS06230	COG1301	dicarboxylic acid transport
M5E07_RS06235	COG0116	Belongs to the methyltransferase superfamily
M5E07_RS06235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5E07_RS06245	COG0540	Belongs to the ATCase OTCase family
M5E07_RS06255	COG2885	chlorophyll binding
M5E07_RS06255	COG3047	cAMP biosynthetic process
M5E07_RS06275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5E07_RS06280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M5E07_RS06280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M5E07_RS06285	COG1254	Belongs to the acylphosphatase family
M5E07_RS06335	COG4774	siderophore transport
M5E07_RS06365	COG0010	Belongs to the arginase family
M5E07_RS06370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5E07_RS06380	COG0174	glutamine synthetase
M5E07_RS06400	COG1944	ATP diphosphatase activity
M5E07_RS06405	COG1252	NADH dehydrogenase
M5E07_RS06420	COG2814	Major facilitator Superfamily
M5E07_RS06430	COG4264	IucA IucC family
M5E07_RS06460	COG0789	Transcriptional regulator
M5E07_RS06475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5E07_RS06475	COG0517	IMP dehydrogenase activity
M5E07_RS06480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M5E07_RS06490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M5E07_RS06495	COG1137	ATPase activity
M5E07_RS06515	COG4122	O-methyltransferase activity
M5E07_RS06525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M5E07_RS06635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_RS06645	COG1136	(ABC) transporter
M5E07_RS06665	COG2351	hydroxyisourate hydrolase activity
M5E07_RS06670	COG2207	Transcriptional regulator
M5E07_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS06695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_RS06710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_RS06715	COG0183	Belongs to the thiolase family
M5E07_RS06720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_RS06725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E07_RS06735	COG4829	muconolactone delta-isomerase
M5E07_RS06740	COG4948	Mandelate Racemase Muconate Lactonizing
M5E07_RS06745	COG0583	DNA-binding transcription factor activity
M5E07_RS06785	COG4638	Rieske (2fe-2S)
M5E07_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS06805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_RS06810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E07_RS06810	COG0543	2 iron, 2 sulfur cluster binding
M5E07_RS06815	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M5E07_RS06820	COG4638	Rieske (2fe-2S)
M5E07_RS06845	COG3453	Protein conserved in bacteria
M5E07_RS06845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E07_RS06860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E07_RS06890	COG1022	Amp-dependent synthetase and ligase
M5E07_RS06900	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS06905	COG1802	Transcriptional regulator
M5E07_RS06960	COG2308	Evidence 4 Homologs of previously reported genes of
M5E07_RS06970	COG1305	Transglutaminase-like
M5E07_RS06980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E07_RS06985	COG0305	Participates in initiation and elongation during chromosome replication
M5E07_RS07000	COG0360	Binds together with S18 to 16S ribosomal RNA
M5E07_RS07005	COG0109	protoheme IX farnesyltransferase activity
M5E07_RS07010	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E07_RS07015	COG1845	cytochrome c oxidase, subunit III
M5E07_RS07020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E07_RS07025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E07_RS07050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E07_RS07065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5E07_RS07070	COG2890	protein-(glutamine-N5) methyltransferase activity
M5E07_RS07075	COG3781	membrane
M5E07_RS07095	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS07100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E07_RS07130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E07_RS07140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5E07_RS07165	COG0729	surface antigen
M5E07_RS07170	COG2911	Protein conserved in bacteria
M5E07_RS07220	COG0471	metal ion transport
M5E07_RS07255	COG0308	aminopeptidase N
M5E07_RS07260	COG0589	response to stress
M5E07_RS07280	COG3135	benzoate transporter
M5E07_RS07290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5E07_RS07295	COG0583	DNA-binding transcription factor activity
M5E07_RS07305	COG0586	Pfam SNARE associated Golgi protein
M5E07_RS07310	COG0183	Belongs to the thiolase family
M5E07_RS07315	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS07325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5E07_RS07330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M5E07_RS07335	COG0824	Thioesterase
M5E07_RS07340	COG1454	alcohol dehydrogenase
M5E07_RS07345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E07_RS07365	COG0069	glutamate synthase activity
M5E07_RS07370	COG2197	response regulator
M5E07_RS07375	COG4585	Histidine kinase
M5E07_RS07380	COG2850	peptidyl-arginine hydroxylation
M5E07_RS07385	COG0424	maF-like protein
M5E07_RS07410	COG0697	spore germination
M5E07_RS07435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5E07_RS07445	COG3698	Phosphodiester glycosidase
M5E07_RS07460	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M5E07_RS07460	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M5E07_RS07460	COG0506	proline dehydrogenase activity
M5E07_RS07470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E07_RS07480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5E07_RS07510	COG0316	Belongs to the HesB IscA family
M5E07_RS07515	COG0822	iron-sulfur transferase activity
M5E07_RS07540	COG0776	regulation of translation
M5E07_RS07545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E07_RS07570	COG0537	adenosine 5'-monophosphoramidase activity
M5E07_RS07600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5E07_RS07605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M5E07_RS07620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5E07_RS07630	COG0133	tryptophan synthase activity
M5E07_RS07635	COG0517	IMP dehydrogenase activity
M5E07_RS07635	COG0516	GMP reductase activity
M5E07_RS07660	COG0612	Peptidase, M16
M5E07_RS07665	COG0552	protein localization to endoplasmic reticulum
M5E07_RS07715	COG2814	Major facilitator Superfamily
M5E07_RS07725	COG2199	diguanylate cyclase activity
M5E07_RS07735	COG0439	Biotin carboxylase
M5E07_RS07740	COG0511	ligase activity, forming carbon-carbon bonds
M5E07_RS07785	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M5E07_RS07790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5E07_RS07810	COG0583	DNA-binding transcription factor activity
M5E07_RS07815	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS07845	COG0697	spore germination
M5E07_RS07850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E07_RS07855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E07_RS07860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M5E07_RS07880	COG2814	Major facilitator Superfamily
M5E07_RS07885	COG0509	glycine decarboxylation via glycine cleavage system
M5E07_RS07900	COG1132	(ABC) transporter
M5E07_RS07925	COG1280	lysine exporter protein (LysE YggA)
M5E07_RS07935	COG0668	transmembrane transport
M5E07_RS07940	COG4774	siderophore transport
M5E07_RS07945	COG3122	Protein conserved in bacteria
M5E07_RS07965	COG0640	Transcriptional regulator
M5E07_RS07970	COG2937	Belongs to the GPAT DAPAT family
M5E07_RS07975	COG0596	Alpha beta hydrolase
M5E07_RS07980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E07_RS07985	COG1335	isochorismatase
M5E07_RS07990	COG0251	oxidation-reduction process
M5E07_RS07995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_RS08000	COG2233	PERMEase
M5E07_RS08005	COG2084	Dehydrogenase
M5E07_RS08010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E07_RS08020	COG4770	biotin carboxylase activity
M5E07_RS08025	COG1024	Enoyl-CoA hydratase
M5E07_RS08030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E07_RS08035	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS08040	COG1309	transcriptional regulator
M5E07_RS08045	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_RS08055	COG2226	methyltransferase
M5E07_RS08065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E07_RS08065	COG1116	anion transmembrane transporter activity
M5E07_RS08075	COG2223	nitrite transmembrane transporter activity
M5E07_RS08080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_RS08080	COG2146	nitrite reductase [NAD(P)H] activity
M5E07_RS08085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_RS08090	COG0243	molybdopterin cofactor binding
M5E07_RS08100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5E07_RS08115	COG0315	cyclic pyranopterin monophosphate synthase activity
M5E07_RS08115	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5E07_RS08120	COG0303	'Molybdopterin
M5E07_RS08125	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5E07_RS08130	COG4149	molybdate abc transporter
M5E07_RS08135	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M5E07_RS08145	COG0475	glutathione-regulated potassium exporter activity
M5E07_RS08145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5E07_RS08155	COG1024	Enoyl-CoA hydratase
M5E07_RS08165	COG0583	DNA-binding transcription factor activity
M5E07_RS08180	COG1280	lysine exporter protein (LysE YggA)
M5E07_RS08205	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS08210	COG1021	2,3-dihydroxybenzoate-AMP ligase
M5E07_RS08215	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_RS08220	COG1024	Enoyl-CoA hydratase
M5E07_RS08225	COG2814	Major facilitator Superfamily
M5E07_RS08240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E07_RS08280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E07_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_RS08295	COG1113	amino acid transport
M5E07_RS08310	COG1301	dicarboxylic acid transport
M5E07_RS08325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E07_RS08335	COG1294	oxidase, subunit
M5E07_RS08340	COG1271	oxidase subunit
M5E07_RS08350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E07_RS08355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5E07_RS08370	COG0583	DNA-binding transcription factor activity
M5E07_RS08375	COG3321	synthase
M5E07_RS08375	COG4221	oxidoreductase activity
M5E07_RS08375	COG0604	alcohol dehydrogenase
M5E07_RS08375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E07_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS08400	COG1902	pentaerythritol trinitrate reductase activity
M5E07_RS08430	COG1309	transcriptional regulator
M5E07_RS08440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5E07_RS08445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E07_RS08450	COG0022	dehydrogenase e1 component
M5E07_RS08455	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E07_RS08460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_RS08470	COG1063	alcohol dehydrogenase
M5E07_RS08485	COG1309	transcriptional regulator
M5E07_RS08495	COG2814	Major facilitator Superfamily
M5E07_RS08510	COG1309	transcriptional regulator
M5E07_RS08520	COG4628	conserved protein (DUF2132)
M5E07_RS08525	COG0596	Alpha beta hydrolase
M5E07_RS08545	COG0583	DNA-binding transcription factor activity
M5E07_RS08550	COG1380	Effector of murein hydrolase LrgA
M5E07_RS08555	COG1346	cytolysis
M5E07_RS08565	COG0406	alpha-ribazole phosphatase activity
M5E07_RS08570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M5E07_RS08585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5E07_RS08600	COG1278	Cold shock
M5E07_RS08620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5E07_RS08625	COG2267	carboxylic ester hydrolase activity
M5E07_RS08630	COG0671	phosphoesterase, PA-phosphatase related
M5E07_RS08630	COG2453	phosphatase
M5E07_RS08645	COG4589	Belongs to the CDS family
M5E07_RS08650	COG1058	Belongs to the CinA family
M5E07_RS08650	COG1546	Belongs to the CinA family
M5E07_RS08680	COG0542	response to heat
M5E07_RS08685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M5E07_RS08710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M5E07_RS08715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M5E07_RS08725	COG0569	domain protein
M5E07_RS08730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5E07_RS08750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E07_RS08760	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5E07_RS08775	COG1294	oxidase, subunit
M5E07_RS08780	COG4890	Cyd operon protein YbgT
M5E07_RS08815	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS08820	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS08825	COG0456	acetyltransferase
M5E07_RS08830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E07_RS08835	COG2207	Transcriptional regulator
M5E07_RS08840	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5E07_RS08845	COG4773	Receptor
M5E07_RS08865	COG0730	response to heat
M5E07_RS08895	COG0772	Belongs to the SEDS family
M5E07_RS08910	COG0148	phosphopyruvate hydratase activity
M5E07_RS08945	COG1902	pentaerythritol trinitrate reductase activity
M5E07_RS08945	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E07_RS08955	COG2267	carboxylic ester hydrolase activity
M5E07_RS08960	COG0583	DNA-binding transcription factor activity
M5E07_RS08965	COG4948	Mandelate Racemase Muconate Lactonizing
M5E07_RS08970	COG4829	muconolactone delta-isomerase
M5E07_RS08980	COG4638	Rieske (2fe-2S)
M5E07_RS08985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M5E07_RS08990	COG0543	2 iron, 2 sulfur cluster binding
M5E07_RS08990	COG0633	Ferredoxin
M5E07_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS09000	COG3135	benzoate transporter
M5E07_RS09005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E07_RS09010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_RS09015	COG0183	Belongs to the thiolase family
M5E07_RS09020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_RS09030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E07_RS09035	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS09040	COG0583	DNA-binding transcription factor activity
M5E07_RS09045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5E07_RS09055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5E07_RS09060	COG0702	epimerase
M5E07_RS09085	COG1011	Hydrolase
M5E07_RS09090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5E07_RS09100	COG2137	regulation of response to DNA damage stimulus
M5E07_RS09115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5E07_RS09135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5E07_RS09150	COG0575	Belongs to the CDS family
M5E07_RS09155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5E07_RS09170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E07_RS09175	COG3852	Histidine kinase
M5E07_RS09190	COG0583	DNA-binding transcription factor activity
M5E07_RS09195	COG0024	Methionine aminopeptidase
M5E07_RS09220	COG1253	flavin adenine dinucleotide binding
M5E07_RS09235	COG0582	viral genome integration into host DNA
M5E07_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS09410	COG5410	chromosome segregation
M5E07_RS09435	COG1598	PFAM Uncharacterised protein family UPF0150
M5E07_RS09575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M5E07_RS09580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M5E07_RS09590	COG2431	L-lysine efflux transmembrane transporter activity
M5E07_RS09670	COG1309	transcriptional regulator
M5E07_RS09675	COG0084	hydrolase, TatD family'
M5E07_RS09695	COG1663	tetraacyldisaccharide 4'-kinase activity
M5E07_RS09700	COG1132	(ABC) transporter
M5E07_RS09710	COG0811	peptide transport
M5E07_RS09715	COG1475	DNA binding
M5E07_RS09720	COG1192	Involved in chromosome partitioning
M5E07_RS09730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5E07_RS09745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E07_RS09750	COG1923	regulation of RNA biosynthetic process
M5E07_RS09755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5E07_RS09760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5E07_RS09765	COG0802	atpase or kinase
M5E07_RS09790	COG2707	UPF0756 membrane protein
M5E07_RS09795	COG0583	DNA-binding transcription factor activity
M5E07_RS09800	COG2814	Major facilitator Superfamily
M5E07_RS09805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5E07_RS09810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5E07_RS09820	COG1454	alcohol dehydrogenase
M5E07_RS09840	COG0519	Catalyzes the synthesis of GMP from XMP
M5E07_RS09840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5E07_RS09845	COG2353	YceI-like domain
M5E07_RS09850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5E07_RS09890	COG2815	serine threonine protein kinase
M5E07_RS09890	COG0515	serine threonine protein kinase
M5E07_RS09915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5E07_RS09925	COG1610	YqeY-like protein
M5E07_RS09940	COG4783	chaperone-mediated protein folding
M5E07_RS09970	COG0167	dihydroorotate dehydrogenase activity
M5E07_RS09995	COG0778	Nitroreductase
M5E07_RS10005	COG0513	Belongs to the DEAD box helicase family
M5E07_RS10025	COG2363	Small membrane protein
M5E07_RS10045	COG0625	glutathione transferase activity
M5E07_RS10050	COG0659	secondary active sulfate transmembrane transporter activity
M5E07_RS10055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5E07_RS10075	COG4772	TonB-dependent receptor
M5E07_RS10080	COG4993	Dehydrogenase
M5E07_RS10085	COG3659	wide pore channel activity
M5E07_RS10090	COG3420	alginic acid biosynthetic process
M5E07_RS10095	COG0710	3-dehydroquinate dehydratase activity
M5E07_RS10100	COG3485	protocatechuate 3,4-dioxygenase
M5E07_RS10105	COG3485	protocatechuate 3,4-dioxygenase
M5E07_RS10110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E07_RS10115	COG2271	Major facilitator Superfamily
M5E07_RS10120	COG0596	Alpha beta hydrolase
M5E07_RS10125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5E07_RS10130	COG0183	Belongs to the thiolase family
M5E07_RS10135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_RS10140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E07_RS10145	COG1414	Transcriptional regulator
M5E07_RS10150	COG0531	amino acid
M5E07_RS10160	COG2814	Major facilitator Superfamily
M5E07_RS10170	COG0445	tRNA wobble uridine modification
M5E07_RS10195	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M5E07_RS10200	COG0138	bifunctional purine biosynthesis protein purh
M5E07_RS10205	COG0151	Belongs to the GarS family
M5E07_RS10210	COG1464	Belongs to the NlpA lipoprotein family
M5E07_RS10215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5E07_RS10220	COG2011	ABC-type metal ion transport system permease component
M5E07_RS10245	COG1045	serine acetyltransferase
M5E07_RS10260	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_RS10275	COG0579	oxidoreductase
M5E07_RS10350	COG1518	maintenance of DNA repeat elements
M5E07_RS10355	COG0204	Acyl-transferase
M5E07_RS10390	COG1464	Belongs to the NlpA lipoprotein family
M5E07_RS10395	COG1464	Belongs to the NlpA lipoprotein family
M5E07_RS10400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5E07_RS10405	COG2011	ABC-type metal ion transport system permease component
M5E07_RS10410	COG0012	GTP binding
M5E07_RS10415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E07_RS10440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5E07_RS10475	COG2207	Transcriptional regulator
M5E07_RS10475	COG1917	Cupin 2, conserved barrel domain protein
M5E07_RS10480	COG0386	Belongs to the glutathione peroxidase family
M5E07_RS10485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E07_RS10490	COG0436	Aminotransferase
M5E07_RS10530	COG0612	Peptidase, M16
M5E07_RS10540	COG1823	symporter activity
M5E07_RS10545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_RS10565	COG0753	catalase activity
M5E07_RS10585	COG2050	protein possibly involved in aromatic compounds catabolism
M5E07_RS10590	COG2351	hydroxyisourate hydrolase activity
M5E07_RS10600	COG1686	Belongs to the peptidase S11 family
M5E07_RS10605	COG1252	NADH dehydrogenase
M5E07_RS10615	COG0415	Belongs to the DNA photolyase family
M5E07_RS10645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5E07_RS10655	COG0693	protein deglycase activity
M5E07_RS10660	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS10665	COG1301	dicarboxylic acid transport
M5E07_RS10675	COG3139	Protein of unknown function (DUF1315)
M5E07_RS10680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E07_RS10685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E07_RS10705	COG0642	Histidine kinase
M5E07_RS10720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5E07_RS10730	COG2203	Gaf domain
M5E07_RS10730	COG2199	diguanylate cyclase activity
M5E07_RS10735	COG1720	tRNA m6t6A37 methyltransferase activity
M5E07_RS10770	COG0826	peptidase U32
M5E07_RS10775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5E07_RS10780	COG3634	alkyl hydroperoxide reductase activity
M5E07_RS10810	COG1643	Atp-dependent helicase
M5E07_RS10855	COG0564	pseudouridine synthase activity
M5E07_RS10860	COG3193	protein, possibly involved in utilization of glycolate and propanediol
M5E07_RS10875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5E07_RS10905	COG0402	S-adenosylhomocysteine deaminase activity
M5E07_RS10925	COG2985	domain, Protein
M5E07_RS10940	COG1131	(ABC) transporter
M5E07_RS10945	COG0842	Transport permease protein
M5E07_RS10960	COG0772	Belongs to the SEDS family
M5E07_RS10965	COG2951	lytic endotransglycosylase activity
M5E07_RS11010	COG0052	Belongs to the universal ribosomal protein uS2 family
M5E07_RS11025	COG2223	nitrite transmembrane transporter activity
M5E07_RS11040	COG2175	clavaminate synthase activity
M5E07_RS11045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_RS11050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5E07_RS11070	COG0583	DNA-binding transcription factor activity
M5E07_RS11080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_RS11095	COG0657	acetylesterase activity
M5E07_RS11100	COG0047	phosphoribosylformylglycinamidine synthase activity
M5E07_RS11100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E07_RS11110	COG0632	four-way junction helicase activity
M5E07_RS11115	COG2255	four-way junction helicase activity
M5E07_RS11130	COG0824	Thioesterase
M5E07_RS11150	COG0823	Involved in the tonB-independent uptake of proteins
M5E07_RS11170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E07_RS11200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5E07_RS11205	COG0628	permease
M5E07_RS11215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5E07_RS11235	COG2333	competence protein COMEC
M5E07_RS11235	COG0658	competence protein
M5E07_RS11240	COG1136	(ABC) transporter
M5E07_RS11245	COG4591	ABC-type transport system involved in lipoprotein release permease component
M5E07_RS11260	COG1671	Belongs to the UPF0178 family
M5E07_RS11295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_RS11310	COG1301	dicarboxylic acid transport
M5E07_RS11325	COG2318	DinB family
M5E07_RS11340	COG1280	lysine exporter protein (LysE YggA)
M5E07_RS11345	COG1522	sequence-specific DNA binding
M5E07_RS11350	COG0519	Catalyzes the synthesis of GMP from XMP
M5E07_RS11360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M5E07_RS11375	COG0019	diaminopimelate decarboxylase activity
M5E07_RS11385	COG1113	amino acid transport
M5E07_RS11390	COG1115	amino acid carrier protein
M5E07_RS11430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M5E07_RS11445	COG0174	glutamine synthetase
M5E07_RS11560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M5E07_RS11575	COG1802	Transcriptional regulator
M5E07_RS11580	COG2217	Heavy metal translocating P-type atpase
M5E07_RS11590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5E07_RS11605	COG2234	aminopeptidase activity
M5E07_RS11615	COG3384	dioxygenase
M5E07_RS11625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E07_RS11630	COG2878	Part of a membrane complex involved in electron transport
M5E07_RS11635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5E07_RS11660	COG0768	penicillin binding
M5E07_RS11665	COG0742	ribosomal rna small subunit methyltransferase
M5E07_RS11695	COG0583	DNA-binding transcription factor activity
M5E07_RS11700	COG2814	Major facilitator Superfamily
M5E07_RS11705	COG1309	transcriptional regulator
M5E07_RS11710	COG1607	acyl-coa hydrolase
M5E07_RS11715	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E07_RS11720	COG1115	amino acid carrier protein
M5E07_RS11725	COG0786	glutamate:sodium symporter activity
M5E07_RS11740	COG2321	neutral zinc metallopeptidase
M5E07_RS11745	COG2354	Protein conserved in bacteria
M5E07_RS11755	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5E07_RS11760	COG2268	Band 7 protein
M5E07_RS11780	COG3733	amine oxidase
M5E07_RS11790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M5E07_RS11800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_RS11815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5E07_RS11820	COG1053	succinate dehydrogenase
M5E07_RS11825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M5E07_RS11830	COG2009	succinate dehydrogenase
M5E07_RS11840	COG2072	flavoprotein involved in K transport
M5E07_RS11845	COG0300	oxidoreductase activity
M5E07_RS11860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E07_RS11860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5E07_RS11880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5E07_RS11905	COG0564	pseudouridine synthase activity
M5E07_RS11930	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M5E07_RS11960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5E07_RS11980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E07_RS12005	COG0586	Pfam SNARE associated Golgi protein
M5E07_RS12030	COG2921	Belongs to the UPF0250 family
M5E07_RS12035	COG0321	lipoyl(octanoyl) transferase activity
M5E07_RS12050	COG0531	amino acid
M5E07_RS12070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5E07_RS12075	COG1648	precorrin-2 dehydrogenase activity
M5E07_RS12075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5E07_RS12080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5E07_RS12090	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5E07_RS12095	COG5295	Hep Hag repeat protein
M5E07_RS12105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M5E07_RS12110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5E07_RS12125	COG0671	phosphoesterase, PA-phosphatase related
M5E07_RS12130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_RS12140	COG1538	Outer membrane efflux protein
M5E07_RS12145	COG0393	Putative heavy-metal-binding
M5E07_RS12155	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS12165	COG0525	valine-tRNA ligase activity
M5E07_RS12175	COG2852	Protein conserved in bacteria
M5E07_RS12190	COG0765	amino acid transport
M5E07_RS12195	COG0765	amino acid transport
M5E07_RS12200	COG1126	abc transporter atp-binding protein
M5E07_RS12205	COG0004	ammonium transporteR
M5E07_RS12210	COG1011	Hydrolase
M5E07_RS12220	COG0642	Histidine kinase
M5E07_RS12225	COG0745	RESPONSE REGULATOR receiver
M5E07_RS12230	COG2194	sulfuric ester hydrolase activity
M5E07_RS12240	COG2814	Major facilitator Superfamily
M5E07_RS12250	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E07_RS12265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E07_RS12270	COG0142	geranyltranstransferase activity
M5E07_RS12275	COG2199	diguanylate cyclase activity
M5E07_RS12280	COG2828	Protein conserved in bacteria
M5E07_RS12285	COG1113	amino acid transport
M5E07_RS12295	COG0582	viral genome integration into host DNA
M5E07_RS12335	COG3177	Filamentation induced by cAMP protein fic
M5E07_RS12345	COG2801	Transposase and inactivated derivatives
M5E07_RS12360	COG0745	RESPONSE REGULATOR receiver
M5E07_RS12365	COG2205	protein histidine kinase activity
M5E07_RS12370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M5E07_RS12375	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M5E07_RS12380	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M5E07_RS12410	COG4716	Myosin-crossreactive antigen
M5E07_RS12425	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M5E07_RS12430	COG2081	HI0933 family
M5E07_RS12440	COG0668	transmembrane transport
M5E07_RS12450	COG4303	Ethanolamine ammonia lyase large subunit
M5E07_RS12455	COG0531	amino acid
M5E07_RS12475	COG0583	DNA-binding transcription factor activity
M5E07_RS12485	COG1278	Cold shock
M5E07_RS12490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5E07_RS12500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5E07_RS12505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5E07_RS12510	COG0713	ATP synthesis coupled electron transport
M5E07_RS12520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5E07_RS12535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M5E07_RS12545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5E07_RS12545	COG0649	NAD binding
M5E07_RS12565	COG2205	protein histidine kinase activity
M5E07_RS12570	COG0745	RESPONSE REGULATOR receiver
M5E07_RS12575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E07_RS12575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5E07_RS12585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E07_RS12600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS12635	COG1399	metal-binding, possibly nucleic acid-binding protein
M5E07_RS12640	COG3101	peptidyl-lysine hydroxylation
M5E07_RS12645	COG0009	L-threonylcarbamoyladenylate synthase
M5E07_RS12650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M5E07_RS12655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M5E07_RS12670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E07_RS12680	COG0339	signal peptide processing
M5E07_RS12690	COG4166	transmembrane transport
M5E07_RS12730	COG4106	trans-aconitate 2-methyltransferase activity
M5E07_RS12740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M5E07_RS12740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E07_RS12745	COG2226	methyltransferase
M5E07_RS12745	COG0596	Alpha beta hydrolase
M5E07_RS12745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_RS12750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5E07_RS12760	COG2193	ferroxidase activity
M5E07_RS12765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E07_RS12770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5E07_RS12780	COG1196	nuclear chromosome segregation
M5E07_RS12790	COG0730	response to heat
M5E07_RS12800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M5E07_RS12810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5E07_RS12830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E07_RS12840	COG3422	double-strand break repair
M5E07_RS12850	COG2824	Alkylphosphonate utilization operon protein PhnA
M5E07_RS12860	COG3189	MarR family transcriptional regulator
M5E07_RS12880	COG0564	pseudouridine synthase activity
M5E07_RS12915	COG0354	folic acid binding
M5E07_RS12940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E07_RS12955	COG0424	maF-like protein
M5E07_RS12960	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5E07_RS12965	COG1792	Involved in formation and maintenance of cell shape
M5E07_RS12970	COG1077	Cell shape determining protein MreB Mrl
M5E07_RS12975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E07_RS12985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E07_RS12995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E07_RS13040	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M5E07_RS13055	COG0679	Auxin Efflux Carrier
M5E07_RS13070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E07_RS13080	COG1970	mechanosensitive ion channel activity
M5E07_RS13085	COG1217	gtp-binding protein TYPA
M5E07_RS13090	COG2233	PERMEase
M5E07_RS13095	COG2813	Specifically methylates the guanine in position
M5E07_RS13100	COG0833	amino acid
M5E07_RS13130	COG0183	Belongs to the thiolase family
M5E07_RS13145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_RS13165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E07_RS13170	COG2207	Transcriptional regulator
M5E07_RS13185	COG0183	Belongs to the thiolase family
M5E07_RS13210	COG1272	protein, Hemolysin III
M5E07_RS13215	COG0477	Major facilitator Superfamily
M5E07_RS13220	COG1408	metallophosphoesterase
M5E07_RS13225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E07_RS13235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5E07_RS13265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M5E07_RS13270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5E07_RS13275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M5E07_RS13280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5E07_RS13285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5E07_RS13290	COG0625	glutathione transferase activity
M5E07_RS13295	COG2969	positive regulation of protein catabolic process
M5E07_RS13355	COG2199	diguanylate cyclase activity
M5E07_RS13385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M5E07_RS13390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M5E07_RS13405	COG0450	alkyl hydroperoxide reductase
M5E07_RS13425	COG0285	dihydrofolate synthase activity
M5E07_RS13430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5E07_RS13475	COG4206	TonB-dependent receptor
M5E07_RS13480	COG2096	Adenosyltransferase
M5E07_RS13500	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M5E07_RS13515	COG0745	RESPONSE REGULATOR receiver
M5E07_RS13520	COG2205	protein histidine kinase activity
M5E07_RS13530	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS13535	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E07_RS13570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M5E07_RS13585	COG0438	transferase activity, transferring glycosyl groups
M5E07_RS13600	COG1215	transferase activity, transferring glycosyl groups
M5E07_RS13605	COG0726	polysaccharide deacetylase
M5E07_RS13620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M5E07_RS13625	COG5002	protein histidine kinase activity
M5E07_RS13630	COG3706	GGDEF domain
M5E07_RS13640	COG0793	Belongs to the peptidase S41A family
M5E07_RS13670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5E07_RS13675	COG0857	belongs to the CobB CobQ family
M5E07_RS13675	COG0280	phosphate acetyltransferase
M5E07_RS13680	COG2226	methyltransferase
M5E07_RS13695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M5E07_RS13695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M5E07_RS13715	COG0740	serine-type endopeptidase activity
M5E07_RS13725	COG4771	TonB-dependent receptor
M5E07_RS13730	COG4774	siderophore transport
M5E07_RS13740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E07_RS13750	COG2813	Specifically methylates the guanine in position
M5E07_RS13750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_RS13765	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5E07_RS13860	COG0788	formyltetrahydrofolate deformylase activity
M5E07_RS13885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5E07_RS13885	COG4651	solute:proton antiporter activity
M5E07_RS13905	COG0724	RNA recognition motif
M5E07_RS13915	COG1929	Belongs to the glycerate kinase type-1 family
M5E07_RS13950	COG2900	Belongs to the SlyX family
M5E07_RS13955	COG0488	(ABC) transporter
M5E07_RS13970	COG1560	Kdo2-lipid A biosynthetic process
M5E07_RS14000	COG0252	asparaginase activity
M5E07_RS14025	COG0473	3-isopropylmalate dehydrogenase activity
M5E07_RS14080	COG1846	Transcriptional regulator
M5E07_RS14090	COG1960	acyl-CoA dehydrogenase activity
M5E07_RS14120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M5E07_RS14140	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E07_RS14145	COG3384	dioxygenase
M5E07_RS14150	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS14165	COG4638	Rieske (2fe-2S)
M5E07_RS14170	COG0583	DNA-binding transcription factor activity
M5E07_RS14195	COG4569	acetaldehyde dehydrogenase (acetylating) activity
M5E07_RS14200	COG3971	2-oxopent-4-enoate hydratase activity
M5E07_RS14205	COG0625	glutathione transferase activity
M5E07_RS14210	COG2378	regulation of single-species biofilm formation
M5E07_RS14215	COG0546	phosphoglycolate phosphatase activity
M5E07_RS14225	COG1530	ribonuclease E activity
M5E07_RS14230	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_RS14255	COG1983	PspC domain protein
M5E07_RS14260	COG0517	IMP dehydrogenase activity
M5E07_RS14260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M5E07_RS14260	COG0617	tRNA 3'-terminal CCA addition
M5E07_RS14275	COG0751	glycine-tRNA ligase activity
M5E07_RS14300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E07_RS14330	COG0493	'glutamate synthase
M5E07_RS14340	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M5E07_RS14355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E07_RS14370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5E07_RS14380	COG0644	oxidoreductase
M5E07_RS14380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M5E07_RS14395	COG4535	Mg2 and Co2 transporter CorC
M5E07_RS14400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M5E07_RS14420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5E07_RS14430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M5E07_RS14440	COG0484	heat shock protein binding
M5E07_RS14445	COG0789	Transcriptional regulator
M5E07_RS14450	COG2841	Protein conserved in bacteria
M5E07_RS14455	COG0598	Magnesium transport protein CorA
M5E07_RS14460	COG1185	polyribonucleotide nucleotidyltransferase activity
M5E07_RS14465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M5E07_RS14470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5E07_RS14475	COG1074	ATP-dependent DNA helicase activity
M5E07_RS14480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M5E07_RS14510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5E07_RS14520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5E07_RS14535	COG2111	Na H antiporter
M5E07_RS14535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5E07_RS14540	COG1006	Multisubunit Na H antiporter MnhC subunit
M5E07_RS14545	COG0651	ATP synthesis coupled electron transport
M5E07_RS14550	COG1863	multisubunit Na H antiporter MnhE subunit
M5E07_RS14555	COG2212	antiporter activity
M5E07_RS14560	COG1320	monovalent cation:proton antiporter activity
M5E07_RS14565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5E07_RS14570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5E07_RS14575	COG0195	Participates in both transcription termination and antitermination
M5E07_RS14580	COG0779	Required for maturation of 30S ribosomal subunits
M5E07_RS14630	COG0237	dephospho-CoA kinase activity
M5E07_RS14640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E07_RS14645	COG3123	guanosine phosphorylase activity
M5E07_RS14650	COG0497	DNA recombination
M5E07_RS14660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5E07_RS14675	COG1289	transmembrane transporter activity
M5E07_RS14685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5E07_RS14700	COG1733	regulation of RNA biosynthetic process
M5E07_RS14765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5E07_RS14795	COG0326	Molecular chaperone. Has ATPase activity
M5E07_RS14810	COG2056	Na+-H+ antiporter family
M5E07_RS14840	COG0085	RNA polymerase activity
M5E07_RS14845	COG0222	ribosome binding
M5E07_RS14850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5E07_RS14855	COG0081	regulation of translation
M5E07_RS14860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M5E07_RS14870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E07_RS14880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5E07_RS14910	COG0546	phosphoglycolate phosphatase activity
M5E07_RS14915	COG1716	ATPase activity
M5E07_RS14940	COG0824	Thioesterase
M5E07_RS14960	COG0181	hydroxymethylbilane synthase activity
M5E07_RS14970	COG3275	phosphorelay sensor kinase activity
M5E07_RS14990	COG1538	Outer membrane efflux protein
M5E07_RS15005	COG0494	nUDIX hydrolase
M5E07_RS15010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M5E07_RS15015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E07_RS15020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5E07_RS15025	COG0772	Belongs to the SEDS family
M5E07_RS15050	COG4974	Belongs to the 'phage' integrase family
M5E07_RS15055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E07_RS15065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5E07_RS15085	COG2197	response regulator
M5E07_RS15090	COG3852	Histidine kinase
M5E07_RS15100	COG0793	Belongs to the peptidase S41A family
M5E07_RS15105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M5E07_RS15110	COG0795	lipopolysaccharide-transporting ATPase activity
M5E07_RS15115	COG0795	lipopolysaccharide-transporting ATPase activity
M5E07_RS15140	COG0586	Pfam SNARE associated Golgi protein
M5E07_RS15155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E07_RS15155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E07_RS15165	COG0004	ammonium transporteR
M5E07_RS15170	COG0347	Belongs to the P(II) protein family
M5E07_RS15180	COG0606	chelatase, subunit chli
M5E07_RS15195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M5E07_RS15210	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_RS15220	COG0477	Major facilitator Superfamily
M5E07_RS15225	COG2860	membrane
M5E07_RS15235	COG1253	flavin adenine dinucleotide binding
M5E07_RS15250	COG0477	Major facilitator Superfamily
M5E07_RS15260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E07_RS15280	COG2814	Major facilitator Superfamily
M5E07_RS15340	COG1652	LysM domain
M5E07_RS15345	COG0758	DNA mediated transformation
M5E07_RS15355	COG0697	spore germination
M5E07_RS15365	COG0386	Belongs to the glutathione peroxidase family
M5E07_RS15395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5E07_RS15445	COG1121	(ABC) transporter
M5E07_RS15450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E07_RS15460	COG2837	iron assimilation
M5E07_RS15500	COG0281	malic enzyme
M5E07_RS15565	COG0519	Catalyzes the synthesis of GMP from XMP
M5E07_RS15565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5E07_RS15570	COG2259	Doxx family
M5E07_RS15575	COG0586	Pfam SNARE associated Golgi protein
M5E07_RS15590	COG1192	Involved in chromosome partitioning
M5E07_RS15600	COG0271	Belongs to the BolA IbaG family
M5E07_RS15620	COG1113	amino acid transport
M5E07_RS15630	COG3724	N-succinylarginine dihydrolase activity
M5E07_RS15635	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_RS15650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E07_RS15665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M5E07_RS15680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E07_RS15690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5E07_RS15695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E07_RS15705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5E07_RS15715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E07_RS15730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5E07_RS15740	COG1215	transferase activity, transferring glycosyl groups
M5E07_RS15750	COG0438	transferase activity, transferring glycosyl groups
M5E07_RS15785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M5E07_RS15790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5E07_RS15795	COG1216	Glycosyl transferase, family 2
M5E07_RS15805	COG0438	transferase activity, transferring glycosyl groups
M5E07_RS15815	COG2244	polysaccharide biosynthetic process
M5E07_RS15825	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS15840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M5E07_RS15850	COG2089	acid synthase
M5E07_RS15855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5E07_RS15860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E07_RS15870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M5E07_RS15875	COG1596	polysaccharide export
M5E07_RS15900	COG0728	peptidoglycan biosynthetic process
M5E07_RS15925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5E07_RS15935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E07_RS15940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5E07_RS15945	COG0546	phosphoglycolate phosphatase activity
M5E07_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_RS15970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5E07_RS15970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5E07_RS15975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E07_RS15980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E07_RS15985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E07_RS15990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E07_RS15995	COG1116	anion transmembrane transporter activity
M5E07_RS16000	COG1309	transcriptional regulator
M5E07_RS16005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5E07_RS16015	COG0196	riboflavin kinase activity
M5E07_RS16020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5E07_RS16030	COG1047	Peptidyl-prolyl cis-trans
M5E07_RS16050	COG0129	dihydroxy-acid dehydratase activity
M5E07_RS16065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5E07_RS16065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E07_RS16070	COG0428	transporter
M5E07_RS16080	COG0733	neurotransmitter:sodium symporter activity
M5E07_RS16135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5E07_RS16140	COG0657	acetylesterase activity
M5E07_RS16155	COG0583	DNA-binding transcription factor activity
M5E07_RS16180	COG2951	lytic endotransglycosylase activity
M5E07_RS16185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5E07_RS16200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5E07_RS16205	COG2388	GCN5-related N-acetyl-transferase
M5E07_RS16210	COG0861	Integral membrane protein TerC family
M5E07_RS16215	COG0402	S-adenosylhomocysteine deaminase activity
M5E07_RS16230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E07_RS16235	COG1230	cation diffusion facilitator family transporter
M5E07_RS16255	COG0706	membrane insertase activity
M5E07_RS16260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M5E07_RS16265	COG0594	ribonuclease P activity