locus-tag	class	description
GVU25_RS00010	COG0592	DNA-directed DNA polymerase activity
GVU25_RS00020	COG0187	DNA topoisomerase II activity
GVU25_RS00030	COG0488	(ABC) transporter
GVU25_RS00045	COG0316	Belongs to the HesB IscA family
GVU25_RS00050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GVU25_RS00055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GVU25_RS00090	COG1012	belongs to the aldehyde dehydrogenase family
GVU25_RS00095	COG0733	neurotransmitter:sodium symporter activity
GVU25_RS00105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GVU25_RS00115	COG0129	dihydroxy-acid dehydratase activity
GVU25_RS00120	COG0129	dihydroxy-acid dehydratase activity
GVU25_RS00145	COG2233	PERMEase
GVU25_RS00165	COG1309	transcriptional regulator
GVU25_RS00195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GVU25_RS00210	COG2852	Protein conserved in bacteria
GVU25_RS00230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GVU25_RS00275	COG2030	dehydratase
GVU25_RS00295	COG0438	transferase activity, transferring glycosyl groups
GVU25_RS00310	COG0438	transferase activity, transferring glycosyl groups
GVU25_RS00315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GVU25_RS00325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GVU25_RS00335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GVU25_RS00350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GVU25_RS00360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GVU25_RS00370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GVU25_RS00375	COG3550	peptidyl-serine autophosphorylation
GVU25_RS00400	COG0271	Belongs to the BolA IbaG family
GVU25_RS00405	COG3094	Invasion gene expression up-regulator, SirB
GVU25_RS00410	COG1192	Involved in chromosome partitioning
GVU25_RS00425	COG0586	Pfam SNARE associated Golgi protein
GVU25_RS00430	COG2259	Doxx family
GVU25_RS00435	COG0519	Catalyzes the synthesis of GMP from XMP
GVU25_RS00435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GVU25_RS00475	COG0281	malic enzyme
GVU25_RS00490	COG3162	membrane
GVU25_RS00495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GVU25_RS00520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GVU25_RS00520	COG0351	phosphomethylpyrimidine kinase
GVU25_RS00520	COG0352	thiamine-phosphate diphosphorylase activity
GVU25_RS00530	COG2814	Major facilitator Superfamily
GVU25_RS00595	COG2837	iron assimilation
GVU25_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GVU25_RS00615	COG1121	(ABC) transporter
GVU25_RS00665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GVU25_RS00680	COG0386	Belongs to the glutathione peroxidase family
GVU25_RS00685	COG0697	spore germination
GVU25_RS00700	COG3547	Transposase (IS116 IS110 IS902 family)
GVU25_RS00715	COG0758	DNA mediated transformation
GVU25_RS00765	COG2814	Major facilitator Superfamily
GVU25_RS00770	COG2814	Major facilitator Superfamily
GVU25_RS00790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GVU25_RS00825	COG1253	flavin adenine dinucleotide binding
GVU25_RS00830	COG3012	SEC-C Motif Domain Protein
GVU25_RS00835	COG2860	membrane
GVU25_RS00840	COG0477	Major facilitator Superfamily
GVU25_RS00850	COG0318	PFAM AMP-dependent synthetase and ligase
GVU25_RS00865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GVU25_RS00880	COG0606	chelatase, subunit chli
GVU25_RS00890	COG0347	Belongs to the P(II) protein family
GVU25_RS00895	COG0004	ammonium transporteR
GVU25_RS00905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GVU25_RS00905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GVU25_RS00920	COG0586	Pfam SNARE associated Golgi protein
GVU25_RS00945	COG0795	lipopolysaccharide-transporting ATPase activity
GVU25_RS00950	COG0795	lipopolysaccharide-transporting ATPase activity
GVU25_RS00955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GVU25_RS00960	COG0793	Belongs to the peptidase S41A family
GVU25_RS00975	COG2197	response regulator
GVU25_RS00985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GVU25_RS00995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GVU25_RS01000	COG4974	Belongs to the 'phage' integrase family
GVU25_RS01025	COG0772	Belongs to the SEDS family
GVU25_RS01035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GVU25_RS01040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GVU25_RS01045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GVU25_RS01050	COG0494	nUDIX hydrolase
GVU25_RS01065	COG1538	Outer membrane efflux protein
GVU25_RS01085	COG3275	phosphorelay sensor kinase activity
GVU25_RS01095	COG0181	hydroxymethylbilane synthase activity
GVU25_RS01115	COG0824	Thioesterase
GVU25_RS01200	COG0081	regulation of translation
GVU25_RS01215	COG0085	RNA polymerase activity
GVU25_RS01250	COG2056	Na+-H+ antiporter family
GVU25_RS01270	COG0326	Molecular chaperone. Has ATPase activity
GVU25_RS01300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GVU25_RS01320	COG1024	Enoyl-CoA hydratase
GVU25_RS01320	COG1250	3-hydroxyacyl-CoA dehydrogenase
GVU25_RS01340	COG0322	excinuclease ABC activity
GVU25_RS01350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GVU25_RS01355	COG1132	(ABC) transporter
GVU25_RS01370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GVU25_RS01400	COG0497	DNA recombination
GVU25_RS01405	COG3123	guanosine phosphorylase activity
GVU25_RS01410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GVU25_RS01420	COG0237	dephospho-CoA kinase activity
GVU25_RS01470	COG0779	Required for maturation of 30S ribosomal subunits
GVU25_RS01475	COG0195	Participates in both transcription termination and antitermination
GVU25_RS01480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GVU25_RS01485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GVU25_RS01495	COG2212	antiporter activity
GVU25_RS01505	COG0651	ATP synthesis coupled electron transport
GVU25_RS01510	COG1006	Multisubunit Na H antiporter MnhC subunit
GVU25_RS01515	COG2111	Na H antiporter
GVU25_RS01515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GVU25_RS01540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GVU25_RS01550	COG2226	methyltransferase
GVU25_RS01570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GVU25_RS01575	COG1074	ATP-dependent DNA helicase activity
GVU25_RS01580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GVU25_RS01620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GVU25_RS01630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GVU25_RS01645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GVU25_RS01650	COG4535	Mg2 and Co2 transporter CorC
GVU25_RS01675	COG0644	oxidoreductase
GVU25_RS01675	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GVU25_RS01685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GVU25_RS01700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVU25_RS01705	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GVU25_RS01715	COG0493	'glutamate synthase
GVU25_RS01725	COG2226	methyltransferase
GVU25_RS01760	COG0751	glycine-tRNA ligase activity
GVU25_RS01770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GVU25_RS01770	COG0517	IMP dehydrogenase activity
GVU25_RS01770	COG0617	tRNA 3'-terminal CCA addition
GVU25_RS01775	COG1983	PspC domain protein
GVU25_RS01805	COG1530	ribonuclease E activity
GVU25_RS01815	COG0546	phosphoglycolate phosphatase activity
GVU25_RS01820	COG3971	2-oxopent-4-enoate hydratase activity
GVU25_RS01825	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GVU25_RS01860	COG0583	DNA-binding transcription factor activity
GVU25_RS01865	COG4638	Rieske (2fe-2S)
GVU25_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
GVU25_RS01885	COG3384	dioxygenase
GVU25_RS01890	COG0446	pyridine nucleotide-disulphide oxidoreductase
GVU25_RS01905	COG0753	catalase activity
GVU25_RS01915	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS01965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GVU25_RS01980	COG0473	3-isopropylmalate dehydrogenase activity
GVU25_RS02000	COG0101	tRNA pseudouridine synthase activity
GVU25_RS02005	COG0252	asparaginase activity
GVU25_RS02035	COG1560	Kdo2-lipid A biosynthetic process
GVU25_RS02045	COG2900	Belongs to the SlyX family
GVU25_RS02080	COG0724	RNA recognition motif
GVU25_RS02095	COG4651	solute:proton antiporter activity
GVU25_RS02095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GVU25_RS02120	COG0788	formyltetrahydrofolate deformylase activity
GVU25_RS02145	COG1295	ribonuclease BN
GVU25_RS02195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GVU25_RS02200	COG1702	phosphate starvation-inducible protein PhoH
GVU25_RS02205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GVU25_RS02210	COG0739	heme binding
GVU25_RS02210	COG1196	nuclear chromosome segregation
GVU25_RS02210	COG0741	lytic transglycosylase activity
GVU25_RS02225	COG2391	methyltransferase activity
GVU25_RS02250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GVU25_RS02255	COG1183	phosphatidylcholine synthase activity
GVU25_RS02300	COG4372	Transposase
GVU25_RS02305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVU25_RS02335	COG1607	acyl-coa hydrolase
GVU25_RS02365	COG2350	Protein conserved in bacteria
GVU25_RS02380	COG3781	membrane
GVU25_RS02390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GVU25_RS02400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GVU25_RS02410	COG1162	GTPase activity
GVU25_RS02415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GVU25_RS02435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GVU25_RS02440	COG0285	dihydrofolate synthase activity
GVU25_RS02450	COG0450	alkyl hydroperoxide reductase
GVU25_RS02465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GVU25_RS02470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GVU25_RS02495	COG2885	chlorophyll binding
GVU25_RS02500	COG3300	MHYT domain
GVU25_RS02500	COG5001	Diguanylate cyclase
GVU25_RS02540	COG2969	positive regulation of protein catabolic process
GVU25_RS02545	COG0625	glutathione transferase activity
GVU25_RS02550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GVU25_RS02570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GVU25_RS02575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GVU25_RS02605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GVU25_RS02615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVU25_RS02620	COG1408	metallophosphoesterase
GVU25_RS02625	COG0477	Major facilitator Superfamily
GVU25_RS02630	COG1272	protein, Hemolysin III
GVU25_RS02660	COG1024	Enoyl-CoA hydratase
GVU25_RS02660	COG1250	3-hydroxyacyl-CoA dehydrogenase
GVU25_RS02665	COG0183	Belongs to the thiolase family
GVU25_RS02670	COG2207	Transcriptional regulator
GVU25_RS02680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GVU25_RS02695	COG0183	Belongs to the thiolase family
GVU25_RS02710	COG0833	amino acid
GVU25_RS02720	COG2233	PERMEase
GVU25_RS02730	COG1970	mechanosensitive ion channel activity
GVU25_RS02735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GVU25_RS02745	COG1902	pentaerythritol trinitrate reductase activity
GVU25_RS02755	COG0675	Transposase, IS605 OrfB family
GVU25_RS02770	COG0354	folic acid binding
GVU25_RS02775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GVU25_RS02780	COG4456	Virulence-associated protein
GVU25_RS02785	COG1487	ribonuclease activity
GVU25_RS02810	COG0564	pseudouridine synthase activity
GVU25_RS02825	COG3189	MarR family transcriptional regulator
GVU25_RS02830	COG2824	Alkylphosphonate utilization operon protein PhnA
GVU25_RS02835	COG3422	double-strand break repair
GVU25_RS02840	COG5342	invasion associated locus B
GVU25_RS02845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GVU25_RS02850	COG2963	transposase activity
GVU25_RS02905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GVU25_RS02920	COG0730	response to heat
GVU25_RS02930	COG1196	nuclear chromosome segregation
GVU25_RS02935	COG3115	cell septum assembly
GVU25_RS02940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GVU25_RS02945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GVU25_RS02950	COG2193	ferroxidase activity
GVU25_RS02955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVU25_RS02955	COG0596	Alpha beta hydrolase
GVU25_RS02955	COG2226	methyltransferase
GVU25_RS02970	COG4106	trans-aconitate 2-methyltransferase activity
GVU25_RS02985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GVU25_RS02990	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GVU25_RS03000	COG0009	L-threonylcarbamoyladenylate synthase
GVU25_RS03005	COG3101	peptidyl-lysine hydroxylation
GVU25_RS03010	COG1399	metal-binding, possibly nucleic acid-binding protein
GVU25_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
GVU25_RS03035	COG1652	LysM domain
GVU25_RS03050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GVU25_RS03065	COG0745	RESPONSE REGULATOR receiver
GVU25_RS03070	COG2205	protein histidine kinase activity
GVU25_RS03075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GVU25_RS03090	COG1752	Esterase of the alpha-beta hydrolase superfamily
GVU25_RS03105	COG2323	membrane
GVU25_RS03110	COG2852	Protein conserved in bacteria
GVU25_RS03120	COG0525	valine-tRNA ligase activity
GVU25_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
GVU25_RS03140	COG0393	Putative heavy-metal-binding
GVU25_RS03145	COG0393	Putative heavy-metal-binding
GVU25_RS03160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GVU25_RS03165	COG0671	phosphoesterase, PA-phosphatase related
GVU25_RS03190	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GVU25_RS03200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GVU25_RS03205	COG1648	precorrin-2 dehydrogenase activity
GVU25_RS03205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GVU25_RS03210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GVU25_RS03215	COG0531	amino acid
GVU25_RS03230	COG0321	lipoyl(octanoyl) transferase activity
GVU25_RS03265	COG0586	Pfam SNARE associated Golgi protein
GVU25_RS03300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GVU25_RS03330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GVU25_RS03340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GVU25_RS03345	COG0358	DNA primase activity
GVU25_RS03355	COG0564	pseudouridine synthase activity
GVU25_RS03380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GVU25_RS03405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVU25_RS03405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GVU25_RS03425	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GVU25_RS03430	COG1053	succinate dehydrogenase
GVU25_RS03435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GVU25_RS03450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVU25_RS03470	COG2354	Protein conserved in bacteria
GVU25_RS03475	COG2321	neutral zinc metallopeptidase
GVU25_RS03480	COG3695	enzyme binding
GVU25_RS03485	COG0589	response to stress
GVU25_RS03515	COG0505	Belongs to the CarA family
GVU25_RS03540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GVU25_RS03545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GVU25_RS03585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GVU25_RS03605	COG1597	lipid kinase activity
GVU25_RS03620	COG0459	protein refolding
GVU25_RS03640	COG2239	Acts as a magnesium transporter
GVU25_RS03650	COG0501	Belongs to the peptidase M48B family
GVU25_RS03655	COG1196	nuclear chromosome segregation
GVU25_RS03655	COG0739	heme binding
GVU25_RS03655	COG0741	lytic transglycosylase activity
GVU25_RS03675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GVU25_RS03700	COG0306	phosphate transporter
GVU25_RS03745	COG4181	ATPase activity
GVU25_RS03750	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GVU25_RS03755	COG0457	Tetratricopeptide repeat
GVU25_RS03755	COG0705	Rhomboid family
GVU25_RS03760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GVU25_RS03775	COG0583	DNA-binding transcription factor activity
GVU25_RS03780	COG2267	carboxylic ester hydrolase activity
GVU25_RS03785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GVU25_RS03790	COG1773	rubredoxin
GVU25_RS03795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GVU25_RS03810	COG3093	addiction module antidote protein HigA
GVU25_RS03815	COG3549	Plasmid maintenance system killer
GVU25_RS03825	COG0175	sulfate reduction
GVU25_RS03895	COG2871	sodium ion transport
GVU25_RS03910	COG2072	flavoprotein involved in K transport
GVU25_RS03915	COG1741	Belongs to the pirin family
GVU25_RS03930	COG3739	integral membrane protein
GVU25_RS03945	COG3706	GGDEF domain
GVU25_RS03965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GVU25_RS03970	COG0512	Glutamine amidotransferase of anthranilate synthase
GVU25_RS03975	COG0174	glutamine synthetase
GVU25_RS03985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GVU25_RS04020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GVU25_RS04025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GVU25_RS04030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GVU25_RS04045	COG1115	amino acid carrier protein
GVU25_RS04055	COG0019	diaminopimelate decarboxylase activity
GVU25_RS04070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GVU25_RS04110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GVU25_RS04150	COG1671	Belongs to the UPF0178 family
GVU25_RS04165	COG4591	ABC-type transport system involved in lipoprotein release permease component
GVU25_RS04170	COG1136	(ABC) transporter
GVU25_RS04175	COG2333	competence protein COMEC
GVU25_RS04175	COG0658	competence protein
GVU25_RS04195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GVU25_RS04200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GVU25_RS04205	COG0628	permease
GVU25_RS04210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GVU25_RS04240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GVU25_RS04260	COG0823	Involved in the tonB-independent uptake of proteins
GVU25_RS04280	COG0824	Thioesterase
GVU25_RS04290	COG2255	four-way junction helicase activity
GVU25_RS04310	COG0778	Nitroreductase
GVU25_RS04315	COG1024	Enoyl-CoA hydratase
GVU25_RS04320	COG1051	belongs to the nudix hydrolase family
GVU25_RS04320	COG1056	cytidyltransferase-related domain
GVU25_RS04325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GVU25_RS04335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GVU25_RS04350	COG4625	pathogenesis
GVU25_RS04360	COG0583	DNA-binding transcription factor activity
GVU25_RS04365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GVU25_RS04370	COG4208	sulfate ABC transporter
GVU25_RS04385	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GVU25_RS04395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GVU25_RS04415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GVU25_RS04440	COG0571	ribonuclease III activity
GVU25_RS04445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GVU25_RS04460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GVU25_RS04485	COG0436	Aminotransferase
GVU25_RS04500	COG0556	nucleotide-excision repair
GVU25_RS04520	COG1733	regulation of RNA biosynthetic process
GVU25_RS04525	COG2814	Major facilitator Superfamily
GVU25_RS04535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GVU25_RS04545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GVU25_RS04550	COG0076	glutamate decarboxylase activity
GVU25_RS04560	COG0573	inorganic phosphate transmembrane transporter activity
GVU25_RS04570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GVU25_RS04580	COG0616	signal peptide processing
GVU25_RS04600	COG2915	High frequency lysogenization protein hflD homolog
GVU25_RS04620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GVU25_RS04625	COG1686	Belongs to the peptidase S11 family
GVU25_RS04650	COG0583	DNA-binding transcription factor activity
GVU25_RS04655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GVU25_RS04660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GVU25_RS04665	COG1067	ATP-dependent peptidase activity
GVU25_RS04700	COG1509	lysine 2,3-aminomutase activity
GVU25_RS04705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GVU25_RS04710	COG1966	Carbon starvation protein
GVU25_RS04715	COG2879	small protein
GVU25_RS04720	COG0714	Associated with various cellular activities
GVU25_RS04750	COG2252	PERMEase
GVU25_RS04755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GVU25_RS04770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GVU25_RS04780	COG0527	aspartate kinase activity
GVU25_RS04785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GVU25_RS04790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GVU25_RS04805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GVU25_RS04820	COG0667	Aldo Keto reductase
GVU25_RS04830	COG1765	OsmC-like protein
GVU25_RS04855	COG0540	Belongs to the ATCase OTCase family
GVU25_RS04865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GVU25_RS04865	COG2885	chlorophyll binding
GVU25_RS04870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GVU25_RS04885	COG4770	biotin carboxylase activity
GVU25_RS04890	COG1024	Enoyl-CoA hydratase
GVU25_RS04895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GVU25_RS04900	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS04905	COG1309	transcriptional regulator
GVU25_RS04910	COG0318	PFAM AMP-dependent synthetase and ligase
GVU25_RS04935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GVU25_RS04940	COG0659	secondary active sulfate transmembrane transporter activity
GVU25_RS04960	COG2363	Small membrane protein
GVU25_RS04975	COG1278	Cold shock
GVU25_RS04980	COG0513	Belongs to the DEAD box helicase family
GVU25_RS04990	COG0778	Nitroreductase
GVU25_RS05015	COG0167	dihydroorotate dehydrogenase activity
GVU25_RS05020	COG1286	toxin biosynthetic process
GVU25_RS05045	COG4783	chaperone-mediated protein folding
GVU25_RS05060	COG1610	YqeY-like protein
GVU25_RS05095	COG2815	serine threonine protein kinase
GVU25_RS05095	COG0515	serine threonine protein kinase
GVU25_RS05130	COG0436	Aminotransferase
GVU25_RS05135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVU25_RS05140	COG0386	Belongs to the glutathione peroxidase family
GVU25_RS05150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GVU25_RS05155	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GVU25_RS05165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GVU25_RS05175	COG0012	GTP binding
GVU25_RS05245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GVU25_RS05270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GVU25_RS05300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GVU25_RS05300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GVU25_RS05340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GVU25_RS05345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GVU25_RS05360	COG2353	YceI-like domain
GVU25_RS05380	COG1454	alcohol dehydrogenase
GVU25_RS05390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GVU25_RS05395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GVU25_RS05400	COG0583	DNA-binding transcription factor activity
GVU25_RS05405	COG2807	transmembrane transport
GVU25_RS05410	COG2707	UPF0756 membrane protein
GVU25_RS05435	COG0802	atpase or kinase
GVU25_RS05440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GVU25_RS05450	COG1923	regulation of RNA biosynthetic process
GVU25_RS05455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GVU25_RS05470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GVU25_RS05480	COG1192	Involved in chromosome partitioning
GVU25_RS05485	COG1475	DNA binding
GVU25_RS05490	COG0811	peptide transport
GVU25_RS05500	COG1132	(ABC) transporter
GVU25_RS05505	COG1663	tetraacyldisaccharide 4'-kinase activity
GVU25_RS05525	COG0084	hydrolase, TatD family'
GVU25_RS05560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GVU25_RS05605	COG2431	L-lysine efflux transmembrane transporter activity
GVU25_RS05620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GVU25_RS05625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GVU25_RS05645	COG1253	flavin adenine dinucleotide binding
GVU25_RS05665	COG1114	Component of the transport system for branched-chain amino acids
GVU25_RS05680	COG0024	Methionine aminopeptidase
GVU25_RS05685	COG0583	DNA-binding transcription factor activity
GVU25_RS05690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GVU25_RS05705	COG3852	Histidine kinase
GVU25_RS05725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GVU25_RS05730	COG0575	Belongs to the CDS family
GVU25_RS05745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GVU25_RS05765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GVU25_RS05780	COG2137	regulation of response to DNA damage stimulus
GVU25_RS05790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GVU25_RS05795	COG1011	Hydrolase
GVU25_RS05835	COG0268	Binds directly to 16S ribosomal RNA
GVU25_RS05840	COG0702	epimerase
GVU25_RS05845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GVU25_RS05860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GVU25_RS05895	COG0316	Belongs to the HesB IscA family
GVU25_RS05900	COG0822	iron-sulfur transferase activity
GVU25_RS05930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GVU25_RS05955	COG0537	adenosine 5'-monophosphoramidase activity
GVU25_RS05985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GVU25_RS06005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GVU25_RS06015	COG0133	tryptophan synthase activity
GVU25_RS06020	COG0517	IMP dehydrogenase activity
GVU25_RS06050	COG0612	Peptidase, M16
GVU25_RS06055	COG0552	protein localization to endoplasmic reticulum
GVU25_RS06110	COG1283	sodium-dependent phosphate transmembrane transporter activity
GVU25_RS06115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GVU25_RS06140	COG0596	Alpha beta hydrolase
GVU25_RS06150	COG0511	ligase activity, forming carbon-carbon bonds
GVU25_RS06155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GVU25_RS06160	COG0642	Histidine kinase
GVU25_RS06175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVU25_RS06190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GVU25_RS06195	COG1944	ATP diphosphatase activity
GVU25_RS06235	COG1309	transcriptional regulator
GVU25_RS06240	COG2130	NADP-dependent
GVU25_RS06275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GVU25_RS06290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GVU25_RS06295	COG2801	Transposase and inactivated derivatives
GVU25_RS06305	COG1132	(ABC) transporter
GVU25_RS06320	COG2814	Major facilitator Superfamily
GVU25_RS06330	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GVU25_RS06335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVU25_RS06375	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS06410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GVU25_RS06465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVU25_RS06475	COG2814	Major facilitator Superfamily
GVU25_RS06480	COG0583	DNA-binding transcription factor activity
GVU25_RS06485	COG4948	Mandelate Racemase Muconate Lactonizing
GVU25_RS06490	COG4829	muconolactone delta-isomerase
GVU25_RS06500	COG4638	Rieske (2fe-2S)
GVU25_RS06505	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GVU25_RS06510	COG0543	2 iron, 2 sulfur cluster binding
GVU25_RS06510	COG0633	Ferredoxin
GVU25_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
GVU25_RS06520	COG3135	benzoate transporter
GVU25_RS06525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GVU25_RS06530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GVU25_RS06535	COG0183	Belongs to the thiolase family
GVU25_RS06540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVU25_RS06545	COG0183	Belongs to the thiolase family
GVU25_RS06555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GVU25_RS06560	COG2937	Belongs to the GPAT DAPAT family
GVU25_RS06565	COG0640	Transcriptional regulator
GVU25_RS06580	COG3619	membrane
GVU25_RS06585	COG3122	Protein conserved in bacteria
GVU25_RS06590	COG0668	transmembrane transport
GVU25_RS06600	COG3706	GGDEF domain
GVU25_RS06610	COG2814	Major facilitator Superfamily
GVU25_RS06655	COG1058	Belongs to the CinA family
GVU25_RS06655	COG1546	Belongs to the CinA family
GVU25_RS06670	COG0372	Belongs to the citrate synthase family
GVU25_RS06700	COG0542	response to heat
GVU25_RS06705	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GVU25_RS06725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GVU25_RS06735	COG0569	domain protein
GVU25_RS06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GVU25_RS06760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVU25_RS06770	COG1585	Membrane protein implicated in regulation of membrane protease activity
GVU25_RS06785	COG1294	oxidase, subunit
GVU25_RS06790	COG4890	Cyd operon protein YbgT
GVU25_RS06800	COG4372	Transposase
GVU25_RS06840	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS06845	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS06860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GVU25_RS06865	COG2207	Transcriptional regulator
GVU25_RS06870	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GVU25_RS06875	COG0730	response to heat
GVU25_RS06880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GVU25_RS06905	COG0772	Belongs to the SEDS family
GVU25_RS06915	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GVU25_RS06920	COG0148	phosphopyruvate hydratase activity
GVU25_RS06950	COG0446	pyridine nucleotide-disulphide oxidoreductase
GVU25_RS06950	COG1902	pentaerythritol trinitrate reductase activity
GVU25_RS06960	COG2267	carboxylic ester hydrolase activity
GVU25_RS06965	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS06970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GVU25_RS06975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GVU25_RS07000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GVU25_RS07010	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GVU25_RS07020	COG0778	Nitroreductase
GVU25_RS07045	COG0126	phosphoglycerate kinase activity
GVU25_RS07055	COG0424	maF-like protein
GVU25_RS07060	COG2850	peptidyl-arginine hydroxylation
GVU25_RS07065	COG4585	Histidine kinase
GVU25_RS07070	COG2197	response regulator
GVU25_RS07090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GVU25_RS07095	COG1454	alcohol dehydrogenase
GVU25_RS07100	COG0824	Thioesterase
GVU25_RS07105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GVU25_RS07125	COG0183	Belongs to the thiolase family
GVU25_RS07140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GVU25_RS07150	COG3135	benzoate transporter
GVU25_RS07160	COG0589	response to stress
GVU25_RS07165	COG0589	response to stress
GVU25_RS07175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVU25_RS07185	COG0308	aminopeptidase N
GVU25_RS07220	COG0729	surface antigen
GVU25_RS07225	COG0477	Major facilitator Superfamily
GVU25_RS07240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GVU25_RS07250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GVU25_RS07260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GVU25_RS07265	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS07285	COG3781	membrane
GVU25_RS07290	COG2890	protein-(glutamine-N5) methyltransferase activity
GVU25_RS07295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GVU25_RS07310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVU25_RS07340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GVU25_RS07345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GVU25_RS07350	COG1845	cytochrome c oxidase, subunit III
GVU25_RS07355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GVU25_RS07365	COG0360	Binds together with S18 to 16S ribosomal RNA
GVU25_RS07370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GVU25_RS07380	COG0305	Participates in initiation and elongation during chromosome replication
GVU25_RS07390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GVU25_RS07405	COG3243	poly(R)-hydroxyalkanoic acid synthase
GVU25_RS07410	COG0183	Belongs to the thiolase family
GVU25_RS07455	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GVU25_RS07460	COG0138	bifunctional purine biosynthesis protein purh
GVU25_RS07465	COG0151	Belongs to the GarS family
GVU25_RS07470	COG1464	Belongs to the NlpA lipoprotein family
GVU25_RS07475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GVU25_RS07480	COG2011	ABC-type metal ion transport system permease component
GVU25_RS07520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GVU25_RS07545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GVU25_RS07555	COG4122	O-methyltransferase activity
GVU25_RS07575	COG1137	ATPase activity
GVU25_RS07580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GVU25_RS07590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GVU25_RS07595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GVU25_RS07595	COG0517	IMP dehydrogenase activity
GVU25_RS07615	COG1643	Atp-dependent helicase
GVU25_RS07675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GVU25_RS07675	COG1017	nitric oxide dioxygenase activity
GVU25_RS07705	COG0352	thiamine-phosphate diphosphorylase activity
GVU25_RS07750	COG4372	Transposase
GVU25_RS07755	COG0612	Peptidase, M16
GVU25_RS07760	COG0384	phenazine biosynthesis protein PhzF
GVU25_RS07775	COG1686	Belongs to the peptidase S11 family
GVU25_RS07780	COG1047	Peptidyl-prolyl cis-trans
GVU25_RS07785	COG0415	Belongs to the DNA photolyase family
GVU25_RS07805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GVU25_RS07810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GVU25_RS07820	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS07830	COG3139	Protein of unknown function (DUF1315)
GVU25_RS07835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GVU25_RS07845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GVU25_RS07855	COG0352	thiamine-phosphate diphosphorylase activity
GVU25_RS07865	COG0642	Histidine kinase
GVU25_RS07870	COG0745	RESPONSE REGULATOR receiver
GVU25_RS07880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GVU25_RS07890	COG1720	tRNA m6t6A37 methyltransferase activity
GVU25_RS07915	COG0789	Transcriptional regulator
GVU25_RS07920	COG0431	NADPH-dependent FMN reductase
GVU25_RS07925	COG0798	PFAM Bile acid sodium symporter
GVU25_RS07930	COG0640	Transcriptional regulator
GVU25_RS07945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GVU25_RS07950	COG3634	alkyl hydroperoxide reductase activity
GVU25_RS07970	COG0675	Transposase, IS605 OrfB family
GVU25_RS07975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GVU25_RS08020	COG1131	(ABC) transporter
GVU25_RS08025	COG0842	Transport permease protein
GVU25_RS08040	COG2951	lytic endotransglycosylase activity
GVU25_RS08065	COG0052	Belongs to the universal ribosomal protein uS2 family
GVU25_RS08070	COG0024	Methionine aminopeptidase
GVU25_RS08090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVU25_RS08095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GVU25_RS08110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GVU25_RS08135	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GVU25_RS08140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GVU25_RS08145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GVU25_RS08155	COG0281	malic enzyme
GVU25_RS08155	COG0280	phosphate acetyltransferase
GVU25_RS08165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GVU25_RS08175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GVU25_RS08175	COG0047	phosphoribosylformylglycinamidine synthase activity
GVU25_RS08180	COG2885	chlorophyll binding
GVU25_RS08280	COG0446	pyridine nucleotide-disulphide oxidoreductase
GVU25_RS08280	COG1902	pentaerythritol trinitrate reductase activity
GVU25_RS08290	COG2203	Gaf domain
GVU25_RS08290	COG5001	Diguanylate cyclase
GVU25_RS08290	COG4251	negative regulation of phosphorylation
GVU25_RS08290	COG3706	GGDEF domain
GVU25_RS08295	COG0418	dihydroorotase activity
GVU25_RS08300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GVU25_RS08315	COG0833	amino acid
GVU25_RS08340	COG4172	Belongs to the ABC transporter superfamily
GVU25_RS08345	COG4239	(ABC) transporter, permease
GVU25_RS08350	COG4174	ABC transporter (Permease)
GVU25_RS08355	COG4166	transmembrane transport
GVU25_RS08360	COG0741	lytic transglycosylase activity
GVU25_RS08360	COG1388	LysM domain
GVU25_RS08360	COG0741	lytic transglycosylase activity
GVU25_RS08360	COG1388	LysM domain
GVU25_RS08365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GVU25_RS08375	COG2816	NAD+ diphosphatase activity
GVU25_RS08405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GVU25_RS08410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GVU25_RS08415	COG3077	Addiction module antitoxin, RelB DinJ family
GVU25_RS08425	COG0006	proline dipeptidase activity
GVU25_RS08430	COG3079	Belongs to the UPF0149 family
GVU25_RS08455	COG4680	protein conserved in bacteria
GVU25_RS08460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GVU25_RS08465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GVU25_RS08485	COG0789	Transcriptional regulator
GVU25_RS08495	COG2194	sulfuric ester hydrolase activity
GVU25_RS08500	COG0745	RESPONSE REGULATOR receiver
GVU25_RS08505	COG0642	Histidine kinase
GVU25_RS08525	COG3706	GGDEF domain
GVU25_RS08540	COG0277	FAD linked oxidase domain protein
GVU25_RS08550	COG2186	Transcriptional regulator
GVU25_RS08570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GVU25_RS08580	COG2234	aminopeptidase activity
GVU25_RS08590	COG3384	dioxygenase
GVU25_RS08600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GVU25_RS08605	COG2878	Part of a membrane complex involved in electron transport
GVU25_RS08610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GVU25_RS08635	COG0768	penicillin binding
GVU25_RS08640	COG0742	ribosomal rna small subunit methyltransferase
GVU25_RS08670	COG1253	flavin adenine dinucleotide binding
GVU25_RS08675	COG0675	Transposase, IS605 OrfB family
GVU25_RS08700	COG3118	belongs to the thioredoxin family
GVU25_RS08705	COG2203	Gaf domain
GVU25_RS08705	COG2199	diguanylate cyclase activity
GVU25_RS08715	COG4681	YaeQ
GVU25_RS08720	COG0523	cobalamin synthesis protein
GVU25_RS08730	COG1607	acyl-coa hydrolase
GVU25_RS08740	COG1752	Esterase of the alpha-beta hydrolase superfamily
GVU25_RS08745	COG2059	Chromate
GVU25_RS08750	COG0786	glutamate:sodium symporter activity
GVU25_RS08760	COG2814	Major facilitator Superfamily
GVU25_RS08765	COG1289	transmembrane transporter activity
GVU25_RS08835	COG2832	Protein of unknown function (DUF454)
GVU25_RS08845	COG5510	response to toxic substance
GVU25_RS08850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GVU25_RS08860	COG0643	Histidine kinase
GVU25_RS08860	COG2198	Histidine kinase
GVU25_RS08860	COG0643	Histidine kinase
GVU25_RS08860	COG2198	Histidine kinase
GVU25_RS08865	COG0840	transmembrane signaling receptor activity
GVU25_RS08890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GVU25_RS08930	COG0489	protein tyrosine kinase activity
GVU25_RS08935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GVU25_RS08935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GVU25_RS08965	COG4716	Myosin-crossreactive antigen
GVU25_RS08980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GVU25_RS08985	COG2081	HI0933 family
GVU25_RS09000	COG0668	transmembrane transport
GVU25_RS09025	COG0583	DNA-binding transcription factor activity
GVU25_RS09030	COG1278	Cold shock
GVU25_RS09035	COG1278	Cold shock
GVU25_RS09050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVU25_RS09055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GVU25_RS09060	COG0713	ATP synthesis coupled electron transport
GVU25_RS09070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVU25_RS09085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GVU25_RS09095	COG0649	NAD binding
GVU25_RS09095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVU25_RS09105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVU25_RS09115	COG0142	geranyltranstransferase activity
GVU25_RS09120	COG2828	Protein conserved in bacteria
GVU25_RS09125	COG1113	amino acid transport
GVU25_RS09130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GVU25_RS09135	COG1840	ABC-type Fe3 transport system, periplasmic component
GVU25_RS09155	COG0560	Phosphoserine phosphatase
GVU25_RS09165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GVU25_RS09175	COG1530	ribonuclease E activity
GVU25_RS09180	COG0424	maF-like protein
GVU25_RS09185	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GVU25_RS09190	COG1792	Involved in formation and maintenance of cell shape
GVU25_RS09195	COG1077	Cell shape determining protein MreB Mrl
GVU25_RS09200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GVU25_RS09210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GVU25_RS09225	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GVU25_RS09240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GVU25_RS09265	COG0577	efflux transmembrane transporter activity
GVU25_RS09265	COG1136	(ABC) transporter
GVU25_RS09275	COG0730	response to heat
GVU25_RS09290	COG4221	oxidoreductase activity
GVU25_RS09300	COG1022	Amp-dependent synthetase and ligase
GVU25_RS09310	COG2050	protein possibly involved in aromatic compounds catabolism
GVU25_RS09320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GVU25_RS09325	COG1090	epimerase
GVU25_RS09335	COG0420	3'-5' exonuclease activity
GVU25_RS09365	COG0735	belongs to the Fur family
GVU25_RS09370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GVU25_RS09375	COG2914	Belongs to the UPF0125 (RnfH) family
GVU25_RS09390	COG0121	glutamine amidotransferase
GVU25_RS09400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GVU25_RS09405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GVU25_RS09410	COG0756	dUTP diphosphatase activity
GVU25_RS09415	COG0210	DNA helicase
GVU25_RS09420	COG2885	chlorophyll binding
GVU25_RS09425	COG0204	Acyl-transferase
GVU25_RS09455	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GVU25_RS09455	COG1674	ftsk spoiiie
GVU25_RS09460	COG0492	ferredoxin-NADP+ reductase activity
GVU25_RS09465	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GVU25_RS09475	COG0456	acetyltransferase
GVU25_RS09530	COG0351	phosphomethylpyrimidine kinase
GVU25_RS09530	COG0352	thiamine-phosphate diphosphorylase activity
GVU25_RS09540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GVU25_RS09560	COG2132	Multicopper oxidase
GVU25_RS09570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GVU25_RS09585	COG4269	membrane
GVU25_RS09605	COG1968	undecaprenyl-diphosphatase activity
GVU25_RS09610	COG1214	PFAM Peptidase M22, glycoprotease
GVU25_RS09620	COG0494	nUDIX hydrolase
GVU25_RS09670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GVU25_RS09675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GVU25_RS09725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVU25_RS09765	COG0037	tRNA processing
GVU25_RS09775	COG0248	Ppx GppA phosphatase
GVU25_RS09800	COG0072	phenylalanine-tRNA ligase activity
GVU25_RS09805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GVU25_RS09835	COG2314	TM2 domain
GVU25_RS09855	COG1238	metal cluster binding
GVU25_RS09865	COG0625	glutathione transferase activity
GVU25_RS09870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GVU25_RS09900	COG0318	PFAM AMP-dependent synthetase and ligase
GVU25_RS09905	COG3028	Belongs to the UPF0307 family
GVU25_RS09915	COG1660	Displays ATPase and GTPase activities
GVU25_RS09930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GVU25_RS09935	COG0617	tRNA 3'-terminal CCA addition
GVU25_RS09940	COG1596	polysaccharide export
GVU25_RS09940	COG1555	photosystem II stabilization
GVU25_RS09945	COG3956	TIGRFAM MazG family protein
GVU25_RS09960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GVU25_RS09980	COG1426	Protein conserved in bacteria
GVU25_RS10000	COG2975	iron-sulfur cluster assembly
GVU25_RS10040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GVU25_RS10070	COG4206	TonB-dependent receptor
GVU25_RS10075	COG2096	Adenosyltransferase
GVU25_RS10110	COG0745	RESPONSE REGULATOR receiver
GVU25_RS10115	COG2205	protein histidine kinase activity
GVU25_RS10125	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS10130	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS10150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVU25_RS10165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GVU25_RS10185	COG0438	transferase activity, transferring glycosyl groups
GVU25_RS10190	COG0463	Glycosyl transferase, family 2
GVU25_RS10200	COG2030	dehydratase
GVU25_RS10215	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GVU25_RS10240	COG0726	polysaccharide deacetylase
GVU25_RS10285	COG0028	Belongs to the TPP enzyme family
GVU25_RS10310	COG2703	oxygen carrier activity
GVU25_RS10315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GVU25_RS10320	COG1136	(ABC) transporter
GVU25_RS10320	COG0577	efflux transmembrane transporter activity
GVU25_RS10325	COG1538	Outer membrane efflux protein
GVU25_RS10330	COG2205	protein histidine kinase activity
GVU25_RS10330	COG0784	Response regulator, receiver
GVU25_RS10330	COG5002	protein histidine kinase activity
GVU25_RS10375	COG0582	viral genome integration into host DNA
GVU25_RS10385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GVU25_RS10395	COG1704	LemA family
GVU25_RS10400	COG5001	Diguanylate cyclase
GVU25_RS10400	COG4251	negative regulation of phosphorylation
GVU25_RS10400	COG2203	Gaf domain
GVU25_RS10400	COG3706	GGDEF domain
GVU25_RS10420	COG1862	Preprotein translocase
GVU25_RS10445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GVU25_RS10470	COG0784	Response regulator, receiver
GVU25_RS10470	COG2205	protein histidine kinase activity
GVU25_RS10470	COG5002	protein histidine kinase activity
GVU25_RS10475	COG1024	Enoyl-CoA hydratase
GVU25_RS10480	COG2084	Dehydrogenase
GVU25_RS10485	COG3622	Belongs to the hyi family
GVU25_RS10515	COG2814	Major facilitator Superfamily
GVU25_RS10525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GVU25_RS10530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GVU25_RS10535	COG0084	hydrolase, TatD family'
GVU25_RS10550	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GVU25_RS10570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GVU25_RS10590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GVU25_RS10745	COG2267	carboxylic ester hydrolase activity
GVU25_RS10760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GVU25_RS10765	COG0857	belongs to the CobB CobQ family
GVU25_RS10765	COG0280	phosphate acetyltransferase
GVU25_RS10770	COG2890	protein-(glutamine-N5) methyltransferase activity
GVU25_RS10775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GVU25_RS10775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GVU25_RS10790	COG0740	serine-type endopeptidase activity
GVU25_RS10800	COG4771	TonB-dependent receptor
GVU25_RS10805	COG4774	siderophore transport
GVU25_RS10810	COG3128	pkhd-type hydroxylase
GVU25_RS10820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GVU25_RS10825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVU25_RS10830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVU25_RS10830	COG2813	Specifically methylates the guanine in position
GVU25_RS10845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GVU25_RS10885	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GVU25_RS10910	COG0179	Fumarylacetoacetate (FAA) hydrolase
GVU25_RS10940	COG0557	exoribonuclease II activity
GVU25_RS10950	COG0339	signal peptide processing
GVU25_RS10955	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GVU25_RS10990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GVU25_RS10995	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS11000	COG2072	flavoprotein involved in K transport
GVU25_RS11005	COG0203	ribosomal protein L17
GVU25_RS11015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GVU25_RS11025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GVU25_RS11050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GVU25_RS11060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GVU25_RS11065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GVU25_RS11075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GVU25_RS11115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GVU25_RS11130	COG0088	Forms part of the polypeptide exit tunnel
GVU25_RS11155	COG0433	COG0433 Predicted ATPase
GVU25_RS11165	COG1959	2 iron, 2 sulfur cluster binding
GVU25_RS11180	COG1301	dicarboxylic acid transport
GVU25_RS11185	COG1946	Acyl-CoA thioesterase
GVU25_RS11190	COG2937	Belongs to the GPAT DAPAT family
GVU25_RS11205	COG4372	Transposase
GVU25_RS11215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GVU25_RS11220	COG1040	competence protein
GVU25_RS11235	COG0598	Magnesium transport protein CorA
GVU25_RS11245	COG2854	intermembrane phospholipid transfer
GVU25_RS11250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GVU25_RS11255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GVU25_RS11260	COG1127	ABC transporter
GVU25_RS11265	COG0513	Belongs to the DEAD box helicase family
GVU25_RS11285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GVU25_RS11310	COG1960	acyl-CoA dehydrogenase activity
GVU25_RS11330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GVU25_RS11340	COG0534	Mate efflux family protein
GVU25_RS11345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GVU25_RS11360	COG0254	rRNA binding
GVU25_RS11365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GVU25_RS11390	COG3547	Transposase (IS116 IS110 IS902 family)
GVU25_RS11410	COG1192	Involved in chromosome partitioning
GVU25_RS11415	COG0628	permease
GVU25_RS11425	COG2814	Major facilitator Superfamily
GVU25_RS11445	COG0277	FAD linked oxidase domain protein
GVU25_RS11450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GVU25_RS11465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GVU25_RS11470	COG5380	lipid catabolic process
GVU25_RS11475	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GVU25_RS11485	COG0335	large ribosomal subunit rRNA binding
GVU25_RS11495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GVU25_RS11500	COG0228	four-way junction DNA binding
GVU25_RS11540	COG0194	GDP metabolic process
GVU25_RS11545	COG1758	RNA polymerase activity
GVU25_RS11550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GVU25_RS11575	COG3609	addiction module antidote protein, CC2985 family
GVU25_RS11580	COG3307	-O-antigen
GVU25_RS11595	COG4969	Belongs to the N-Me-Phe pilin family
GVU25_RS11625	COG1132	(ABC) transporter
GVU25_RS11635	COG1215	transferase activity, transferring glycosyl groups
GVU25_RS11650	COG0438	transferase activity, transferring glycosyl groups
GVU25_RS11660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GVU25_RS11665	COG1704	LemA family
GVU25_RS11670	COG0493	'glutamate synthase
GVU25_RS11675	COG0067	glutamate synthase
GVU25_RS11675	COG0069	glutamate synthase activity
GVU25_RS11675	COG0070	glutamate synthase
GVU25_RS11725	COG2226	methyltransferase
GVU25_RS11730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GVU25_RS11735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GVU25_RS11740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GVU25_RS11755	COG0275	rRNA processing
GVU25_RS11760	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GVU25_RS11770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GVU25_RS11790	COG0488	(ABC) transporter
GVU25_RS11800	COG4221	oxidoreductase activity
GVU25_RS11820	COG0745	RESPONSE REGULATOR receiver
GVU25_RS11830	COG0427	acetyl-CoA hydrolase
GVU25_RS11870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GVU25_RS11880	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GVU25_RS11890	COG0697	spore germination
GVU25_RS11905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GVU25_RS11945	COG3158	transport of potassium into the cell
GVU25_RS11975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GVU25_RS11980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GVU25_RS11985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GVU25_RS11995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GVU25_RS12040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GVU25_RS12045	COG0668	transmembrane transport
GVU25_RS12055	COG1519	Transferase
GVU25_RS12060	COG1902	pentaerythritol trinitrate reductase activity
GVU25_RS12085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GVU25_RS12110	COG0426	domain, Protein
GVU25_RS12110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GVU25_RS12115	COG2119	membrane
GVU25_RS12140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GVU25_RS12145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GVU25_RS12155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GVU25_RS12175	COG0189	ligase activity
GVU25_RS12195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GVU25_RS12200	COG0708	Exodeoxyribonuclease III
GVU25_RS12205	COG1393	Belongs to the ArsC family
GVU25_RS12220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GVU25_RS12260	COG0471	metal ion transport
GVU25_RS12275	COG3150	esterase
GVU25_RS12290	COG2918	glutathione biosynthetic process
GVU25_RS12305	COG2733	membrane
GVU25_RS12310	COG0436	Aminotransferase
GVU25_RS12315	COG0534	Mate efflux family protein
GVU25_RS12370	COG0560	Phosphoserine phosphatase
GVU25_RS12370	COG3830	Belongs to the UPF0237 family
GVU25_RS12385	COG1335	isochorismatase
GVU25_RS12395	COG2814	Major facilitator Superfamily
GVU25_RS12400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GVU25_RS12410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GVU25_RS12420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GVU25_RS12425	COG2983	Belongs to the UPF0260 family
GVU25_RS12430	COG5487	UPF0391 membrane protein
GVU25_RS12445	COG1194	a g-specific adenine glycosylase
GVU25_RS12460	COG2818	Glycosylase
GVU25_RS12465	COG1064	alcohol dehydrogenase
GVU25_RS12485	COG3023	N-Acetylmuramoyl-L-alanine amidase
GVU25_RS12500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GVU25_RS12515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GVU25_RS12520	COG0546	phosphoglycolate phosphatase activity
GVU25_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
GVU25_RS12550	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GVU25_RS12550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GVU25_RS12555	COG1309	transcriptional regulator
GVU25_RS12565	COG0196	riboflavin kinase activity
GVU25_RS12570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GVU25_RS12580	COG1047	Peptidyl-prolyl cis-trans
GVU25_RS12585	COG2133	pyrroloquinoline quinone binding
GVU25_RS12590	COG2814	Major facilitator Superfamily
GVU25_RS12620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GVU25_RS12640	COG3547	Transposase (IS116 IS110 IS902 family)
GVU25_RS12665	COG0675	Transposase, IS605 OrfB family
GVU25_RS12675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GVU25_RS12695	COG2951	lytic endotransglycosylase activity
GVU25_RS12700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GVU25_RS12715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GVU25_RS12720	COG1063	alcohol dehydrogenase
GVU25_RS12740	COG0861	Integral membrane protein TerC family
GVU25_RS12745	COG0402	S-adenosylhomocysteine deaminase activity
GVU25_RS12765	COG1230	cation diffusion facilitator family transporter
GVU25_RS12790	COG0706	membrane insertase activity
GVU25_RS12795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GVU25_RS12800	COG0594	ribonuclease P activity
GVU25_RS12810	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GVU25_RS12845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GVU25_RS12855	COG1570	exodeoxyribonuclease VII activity
GVU25_RS12900	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GVU25_RS12905	COG3657	addiction module killer protein
GVU25_RS12915	COG0659	secondary active sulfate transmembrane transporter activity
GVU25_RS12920	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GVU25_RS12925	COG3657	addiction module killer protein
GVU25_RS13015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GVU25_RS13070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GVU25_RS13315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GVU25_RS13390	COG0582	viral genome integration into host DNA
GVU25_RS13420	COG4372	Transposase
GVU25_RS13450	COG3210	domain, Protein
GVU25_RS13455	COG2831	hemolysin activation secretion protein
GVU25_RS13470	COG1373	ATPase (AAA superfamily
GVU25_RS13535	COG3012	SEC-C Motif Domain Protein
GVU25_RS13560	COG2194	sulfuric ester hydrolase activity
GVU25_RS13565	COG0642	Histidine kinase
GVU25_RS13570	COG0745	RESPONSE REGULATOR receiver
GVU25_RS13625	COG1192	Involved in chromosome partitioning
GVU25_RS13640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GVU25_RS13680	COG0488	(ABC) transporter