locus-tag	class	description
J4G45_RS00025	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4G45_RS00030	COG3657	addiction module killer protein
J4G45_RS00040	COG0659	secondary active sulfate transmembrane transporter activity
J4G45_RS00045	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4G45_RS00050	COG3657	addiction module killer protein
J4G45_RS00060	COG2801	Transposase and inactivated derivatives
J4G45_RS00105	COG3173	Aminoglycoside phosphotransferase
J4G45_RS00140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J4G45_RS00150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4G45_RS00150	COG0551	DNA topoisomerase type I activity
J4G45_RS00215	COG4974	Belongs to the 'phage' integrase family
J4G45_RS00250	COG1683	Conserved Protein
J4G45_RS00285	COG1230	cation diffusion facilitator family transporter
J4G45_RS00295	COG0789	Transcriptional regulator
J4G45_RS00300	COG0582	viral genome integration into host DNA
J4G45_RS00335	COG3210	domain, Protein
J4G45_RS00340	COG2831	hemolysin activation secretion protein
J4G45_RS00355	COG1373	ATPase (AAA superfamily
J4G45_RS00415	COG3012	SEC-C Motif Domain Protein
J4G45_RS00480	COG1192	Involved in chromosome partitioning
J4G45_RS00495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J4G45_RS00515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J4G45_RS00540	COG2801	Transposase and inactivated derivatives
J4G45_RS00575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4G45_RS00585	COG1570	exodeoxyribonuclease VII activity
J4G45_RS00630	COG3077	Addiction module antitoxin, RelB DinJ family
J4G45_RS00635	COG0488	(ABC) transporter
J4G45_RS00685	COG2132	Multicopper oxidase
J4G45_RS00705	COG4221	oxidoreductase activity
J4G45_RS00710	COG0488	(ABC) transporter
J4G45_RS00735	COG2801	Transposase and inactivated derivatives
J4G45_RS00770	COG2801	Transposase and inactivated derivatives
J4G45_RS00785	COG3077	Addiction module antitoxin, RelB DinJ family
J4G45_RS00810	COG3173	Aminoglycoside phosphotransferase
J4G45_RS00815	COG0488	(ABC) transporter
J4G45_RS00840	COG2801	Transposase and inactivated derivatives
J4G45_RS00845	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4G45_RS00850	COG3657	addiction module killer protein
J4G45_RS00885	COG2801	Transposase and inactivated derivatives
J4G45_RS00890	COG0745	RESPONSE REGULATOR receiver
J4G45_RS00895	COG5002	protein histidine kinase activity
J4G45_RS00915	COG0281	malic enzyme
J4G45_RS00960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J4G45_RS00960	COG0519	Catalyzes the synthesis of GMP from XMP
J4G45_RS00965	COG2259	Doxx family
J4G45_RS00970	COG0586	Pfam SNARE associated Golgi protein
J4G45_RS00985	COG1192	Involved in chromosome partitioning
J4G45_RS00990	COG3094	Invasion gene expression up-regulator, SirB
J4G45_RS00995	COG0271	Belongs to the BolA IbaG family
J4G45_RS01015	COG3550	peptidyl-serine autophosphorylation
J4G45_RS01020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J4G45_RS01035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4G45_RS01050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J4G45_RS01065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4G45_RS01080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J4G45_RS01085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J4G45_RS01100	COG1216	Glycosyl transferase, family 2
J4G45_RS01105	COG5039	Polysaccharide pyruvyl transferase
J4G45_RS01115	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J4G45_RS01135	COG2852	Protein conserved in bacteria
J4G45_RS01150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J4G45_RS01180	COG1309	transcriptional regulator
J4G45_RS01195	COG2233	PERMEase
J4G45_RS01220	COG0129	dihydroxy-acid dehydratase activity
J4G45_RS01225	COG0129	dihydroxy-acid dehydratase activity
J4G45_RS01235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J4G45_RS01245	COG0733	neurotransmitter:sodium symporter activity
J4G45_RS01250	COG1012	belongs to the aldehyde dehydrogenase family
J4G45_RS01290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J4G45_RS01295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J4G45_RS01300	COG0316	Belongs to the HesB IscA family
J4G45_RS01320	COG0488	(ABC) transporter
J4G45_RS01330	COG0187	DNA topoisomerase II activity
J4G45_RS01340	COG0592	DNA-directed DNA polymerase activity
J4G45_RS01355	COG0594	ribonuclease P activity
J4G45_RS01360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J4G45_RS01365	COG0706	membrane insertase activity
J4G45_RS01390	COG1230	cation diffusion facilitator family transporter
J4G45_RS01410	COG0402	S-adenosylhomocysteine deaminase activity
J4G45_RS01415	COG0861	Integral membrane protein TerC family
J4G45_RS01425	COG1063	alcohol dehydrogenase
J4G45_RS01430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4G45_RS01445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J4G45_RS01450	COG2951	lytic endotransglycosylase activity
J4G45_RS01470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J4G45_RS01480	COG0657	acetylesterase activity
J4G45_RS01490	COG0675	Transposase, IS605 OrfB family
J4G45_RS01500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4G45_RS01530	COG2814	Major facilitator Superfamily
J4G45_RS01535	COG2133	pyrroloquinoline quinone binding
J4G45_RS01540	COG1047	Peptidyl-prolyl cis-trans
J4G45_RS01550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J4G45_RS01555	COG0196	riboflavin kinase activity
J4G45_RS01565	COG1309	transcriptional regulator
J4G45_RS01570	COG1116	anion transmembrane transporter activity
J4G45_RS01575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J4G45_RS01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4G45_RS01585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4G45_RS01590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4G45_RS01620	COG0431	NADPH-dependent FMN reductase
J4G45_RS01625	COG1028	Short-chain dehydrogenase reductase Sdr
J4G45_RS01630	COG0546	phosphoglycolate phosphatase activity
J4G45_RS01635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J4G45_RS01650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J4G45_RS01665	COG3023	N-Acetylmuramoyl-L-alanine amidase
J4G45_RS01685	COG1064	alcohol dehydrogenase
J4G45_RS01690	COG2818	Glycosylase
J4G45_RS01705	COG1194	a g-specific adenine glycosylase
J4G45_RS01720	COG5487	UPF0391 membrane protein
J4G45_RS01725	COG2983	Belongs to the UPF0260 family
J4G45_RS01730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J4G45_RS01740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J4G45_RS01750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4G45_RS01755	COG2814	Major facilitator Superfamily
J4G45_RS01765	COG1335	isochorismatase
J4G45_RS01780	COG3830	Belongs to the UPF0237 family
J4G45_RS01780	COG0560	Phosphoserine phosphatase
J4G45_RS01840	COG0534	Mate efflux family protein
J4G45_RS01845	COG0436	Aminotransferase
J4G45_RS01850	COG2733	membrane
J4G45_RS01865	COG2918	glutathione biosynthetic process
J4G45_RS01880	COG3150	esterase
J4G45_RS01895	COG0471	metal ion transport
J4G45_RS01940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J4G45_RS01955	COG1393	Belongs to the ArsC family
J4G45_RS01960	COG0708	Exodeoxyribonuclease III
J4G45_RS01965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J4G45_RS02000	COG0189	ligase activity
J4G45_RS02020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J4G45_RS02030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J4G45_RS02035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J4G45_RS02060	COG2119	membrane
J4G45_RS02065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J4G45_RS02065	COG0426	domain, Protein
J4G45_RS02090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4G45_RS02115	COG1902	pentaerythritol trinitrate reductase activity
J4G45_RS02120	COG1519	Transferase
J4G45_RS02130	COG0668	transmembrane transport
J4G45_RS02135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J4G45_RS02185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J4G45_RS02195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J4G45_RS02200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J4G45_RS02205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4G45_RS02235	COG3158	transport of potassium into the cell
J4G45_RS02285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J4G45_RS02300	COG0697	spore germination
J4G45_RS02310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J4G45_RS02320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J4G45_RS02355	COG0427	acetyl-CoA hydrolase
J4G45_RS02385	COG4221	oxidoreductase activity
J4G45_RS02395	COG0488	(ABC) transporter
J4G45_RS02415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4G45_RS02425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J4G45_RS02430	COG0275	rRNA processing
J4G45_RS02445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J4G45_RS02450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4G45_RS02455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4G45_RS02460	COG2226	methyltransferase
J4G45_RS02510	COG0070	glutamate synthase
J4G45_RS02510	COG0069	glutamate synthase activity
J4G45_RS02510	COG0067	glutamate synthase
J4G45_RS02515	COG0493	'glutamate synthase
J4G45_RS02520	COG1704	LemA family
J4G45_RS02525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
J4G45_RS02535	COG4969	Belongs to the N-Me-Phe pilin family
J4G45_RS02550	COG3307	-O-antigen
J4G45_RS02555	COG3609	addiction module antidote protein, CC2985 family
J4G45_RS02580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4G45_RS02585	COG1758	RNA polymerase activity
J4G45_RS02590	COG0194	GDP metabolic process
J4G45_RS02635	COG0228	four-way junction DNA binding
J4G45_RS02640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J4G45_RS02650	COG0335	large ribosomal subunit rRNA binding
J4G45_RS02660	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
J4G45_RS02665	COG5380	lipid catabolic process
J4G45_RS02670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J4G45_RS02685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4G45_RS02690	COG0277	FAD linked oxidase domain protein
J4G45_RS02710	COG2814	Major facilitator Superfamily
J4G45_RS02715	COG2032	superoxide dismutase activity
J4G45_RS02720	COG0628	permease
J4G45_RS02725	COG1192	Involved in chromosome partitioning
J4G45_RS02750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4G45_RS02755	COG0254	rRNA binding
J4G45_RS02770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J4G45_RS02775	COG0534	Mate efflux family protein
J4G45_RS02785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4G45_RS02800	COG2318	DinB family
J4G45_RS02805	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS02825	COG0408	coproporphyrinogen oxidase activity
J4G45_RS02830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4G45_RS02850	COG0513	Belongs to the DEAD box helicase family
J4G45_RS02855	COG1127	ABC transporter
J4G45_RS02860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J4G45_RS02865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J4G45_RS02870	COG2854	intermembrane phospholipid transfer
J4G45_RS02880	COG0598	Magnesium transport protein CorA
J4G45_RS02895	COG1040	competence protein
J4G45_RS02900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4G45_RS02920	COG2937	Belongs to the GPAT DAPAT family
J4G45_RS02925	COG1946	Acyl-CoA thioesterase
J4G45_RS02930	COG1301	dicarboxylic acid transport
J4G45_RS02945	COG1959	2 iron, 2 sulfur cluster binding
J4G45_RS02955	COG0433	COG0433 Predicted ATPase
J4G45_RS02980	COG0088	Forms part of the polypeptide exit tunnel
J4G45_RS02995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J4G45_RS03005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J4G45_RS03035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J4G45_RS03045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J4G45_RS03050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J4G45_RS03060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J4G45_RS03085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J4G45_RS03095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J4G45_RS03105	COG0203	ribosomal protein L17
J4G45_RS03110	COG2072	flavoprotein involved in K transport
J4G45_RS03115	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS03120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J4G45_RS03155	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
J4G45_RS03160	COG0339	signal peptide processing
J4G45_RS03170	COG0557	exoribonuclease II activity
J4G45_RS03200	COG0179	Fumarylacetoacetate (FAA) hydrolase
J4G45_RS03225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J4G45_RS03265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J4G45_RS03280	COG2813	Specifically methylates the guanine in position
J4G45_RS03280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4G45_RS03285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4G45_RS03290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4G45_RS03300	COG3128	pkhd-type hydroxylase
J4G45_RS03305	COG4774	siderophore transport
J4G45_RS03310	COG4771	TonB-dependent receptor
J4G45_RS03320	COG0740	serine-type endopeptidase activity
J4G45_RS03335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
J4G45_RS03335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
J4G45_RS03340	COG2890	protein-(glutamine-N5) methyltransferase activity
J4G45_RS03345	COG1476	TRANSCRIPTIONal
J4G45_RS03360	COG0280	phosphate acetyltransferase
J4G45_RS03360	COG0857	belongs to the CobB CobQ family
J4G45_RS03365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J4G45_RS03380	COG2267	carboxylic ester hydrolase activity
J4G45_RS03410	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J4G45_RS03425	COG0084	hydrolase, TatD family'
J4G45_RS03430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J4G45_RS03435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4G45_RS03445	COG2814	Major facilitator Superfamily
J4G45_RS03475	COG3622	Belongs to the hyi family
J4G45_RS03480	COG2084	Dehydrogenase
J4G45_RS03485	COG1024	Enoyl-CoA hydratase
J4G45_RS03490	COG0784	Response regulator, receiver
J4G45_RS03490	COG5002	protein histidine kinase activity
J4G45_RS03490	COG2205	protein histidine kinase activity
J4G45_RS03495	COG0675	Transposase, IS605 OrfB family
J4G45_RS03515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4G45_RS03535	COG1862	Preprotein translocase
J4G45_RS03550	COG2203	Gaf domain
J4G45_RS03550	COG3706	GGDEF domain
J4G45_RS03550	COG4251	negative regulation of phosphorylation
J4G45_RS03550	COG5001	Diguanylate cyclase
J4G45_RS03555	COG1704	LemA family
J4G45_RS03565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J4G45_RS03585	COG2205	protein histidine kinase activity
J4G45_RS03585	COG5002	protein histidine kinase activity
J4G45_RS03585	COG0784	Response regulator, receiver
J4G45_RS03590	COG1538	Outer membrane efflux protein
J4G45_RS03595	COG1136	(ABC) transporter
J4G45_RS03595	COG0577	efflux transmembrane transporter activity
J4G45_RS03600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4G45_RS03605	COG2703	oxygen carrier activity
J4G45_RS03630	COG0028	Belongs to the TPP enzyme family
J4G45_RS03655	COG0726	polysaccharide deacetylase
J4G45_RS03680	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J4G45_RS03695	COG1215	transferase activity, transferring glycosyl groups
J4G45_RS03710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J4G45_RS03725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4G45_RS03745	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS03750	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS03760	COG2205	protein histidine kinase activity
J4G45_RS03765	COG0745	RESPONSE REGULATOR receiver
J4G45_RS03780	COG2315	Protein conserved in bacteria
J4G45_RS03785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J4G45_RS03800	COG2096	Adenosyltransferase
J4G45_RS03805	COG4206	TonB-dependent receptor
J4G45_RS03835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J4G45_RS03875	COG2975	iron-sulfur cluster assembly
J4G45_RS03895	COG1426	Protein conserved in bacteria
J4G45_RS03915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4G45_RS03930	COG3956	TIGRFAM MazG family protein
J4G45_RS03935	COG1555	photosystem II stabilization
J4G45_RS03935	COG1596	polysaccharide export
J4G45_RS03940	COG0617	tRNA 3'-terminal CCA addition
J4G45_RS03945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4G45_RS03960	COG1660	Displays ATPase and GTPase activities
J4G45_RS03970	COG3028	Belongs to the UPF0307 family
J4G45_RS03975	COG0318	PFAM AMP-dependent synthetase and ligase
J4G45_RS04005	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J4G45_RS04010	COG0625	glutathione transferase activity
J4G45_RS04020	COG1238	metal cluster binding
J4G45_RS04045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J4G45_RS04050	COG0072	phenylalanine-tRNA ligase activity
J4G45_RS04075	COG0248	Ppx GppA phosphatase
J4G45_RS04085	COG0037	tRNA processing
J4G45_RS04125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4G45_RS04190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J4G45_RS04195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J4G45_RS04245	COG0494	nUDIX hydrolase
J4G45_RS04255	COG1214	PFAM Peptidase M22, glycoprotease
J4G45_RS04260	COG1968	undecaprenyl-diphosphatase activity
J4G45_RS04280	COG4269	membrane
J4G45_RS04295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4G45_RS04305	COG2132	Multicopper oxidase
J4G45_RS04325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J4G45_RS04335	COG0352	thiamine-phosphate diphosphorylase activity
J4G45_RS04335	COG0351	phosphomethylpyrimidine kinase
J4G45_RS04350	COG1981	membrane
J4G45_RS04390	COG0456	acetyltransferase
J4G45_RS04400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J4G45_RS04405	COG0492	ferredoxin-NADP+ reductase activity
J4G45_RS04410	COG1674	ftsk spoiiie
J4G45_RS04410	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4G45_RS04425	COG2894	cell division
J4G45_RS04440	COG0204	Acyl-transferase
J4G45_RS04445	COG2885	chlorophyll binding
J4G45_RS04450	COG0210	DNA helicase
J4G45_RS04455	COG0756	dUTP diphosphatase activity
J4G45_RS04460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4G45_RS04465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J4G45_RS04475	COG0121	glutamine amidotransferase
J4G45_RS04495	COG2914	Belongs to the UPF0125 (RnfH) family
J4G45_RS04500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4G45_RS04505	COG0735	belongs to the Fur family
J4G45_RS04535	COG0420	3'-5' exonuclease activity
J4G45_RS04545	COG1090	epimerase
J4G45_RS04560	COG2050	protein possibly involved in aromatic compounds catabolism
J4G45_RS04570	COG1022	Amp-dependent synthetase and ligase
J4G45_RS04580	COG0300	oxidoreductase activity
J4G45_RS04595	COG0730	response to heat
J4G45_RS04605	COG1136	(ABC) transporter
J4G45_RS04605	COG0577	efflux transmembrane transporter activity
J4G45_RS04630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J4G45_RS04645	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
J4G45_RS04665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J4G45_RS04675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J4G45_RS04680	COG1077	Cell shape determining protein MreB Mrl
J4G45_RS04685	COG1792	Involved in formation and maintenance of cell shape
J4G45_RS04690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
J4G45_RS04695	COG0424	maF-like protein
J4G45_RS04700	COG1530	ribonuclease E activity
J4G45_RS04710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4G45_RS04740	COG1840	ABC-type Fe3 transport system, periplasmic component
J4G45_RS04745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J4G45_RS04750	COG1113	amino acid transport
J4G45_RS04755	COG2828	Protein conserved in bacteria
J4G45_RS04760	COG0142	geranyltranstransferase activity
J4G45_RS04770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4G45_RS04780	COG0649	NAD binding
J4G45_RS04780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4G45_RS04790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J4G45_RS04805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4G45_RS04815	COG0713	ATP synthesis coupled electron transport
J4G45_RS04820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4G45_RS04825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4G45_RS04840	COG1278	Cold shock
J4G45_RS04845	COG1278	Cold shock
J4G45_RS04850	COG0583	DNA-binding transcription factor activity
J4G45_RS04875	COG0668	transmembrane transport
J4G45_RS04890	COG2081	HI0933 family
J4G45_RS04915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4G45_RS04925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4G45_RS04925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4G45_RS04930	COG0489	protein tyrosine kinase activity
J4G45_RS04975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4G45_RS05000	COG0840	transmembrane signaling receptor activity
J4G45_RS05005	COG2198	Histidine kinase
J4G45_RS05005	COG2198	Histidine kinase
J4G45_RS05005	COG0643	Histidine kinase
J4G45_RS05005	COG0643	Histidine kinase
J4G45_RS05015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4G45_RS05020	COG5510	response to toxic substance
J4G45_RS05030	COG2832	Protein of unknown function (DUF454)
J4G45_RS05100	COG1289	transmembrane transporter activity
J4G45_RS05105	COG2814	Major facilitator Superfamily
J4G45_RS05115	COG0786	glutamate:sodium symporter activity
J4G45_RS05125	COG2826	transposase and inactivated derivatives, IS30 family
J4G45_RS05135	COG1752	Esterase of the alpha-beta hydrolase superfamily
J4G45_RS05145	COG1607	acyl-coa hydrolase
J4G45_RS05155	COG0523	cobalamin synthesis protein
J4G45_RS05160	COG4681	YaeQ
J4G45_RS05170	COG2203	Gaf domain
J4G45_RS05170	COG2199	diguanylate cyclase activity
J4G45_RS05175	COG3118	belongs to the thioredoxin family
J4G45_RS05195	COG1253	flavin adenine dinucleotide binding
J4G45_RS05220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J4G45_RS05225	COG0742	ribosomal rna small subunit methyltransferase
J4G45_RS05230	COG0768	penicillin binding
J4G45_RS05255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4G45_RS05260	COG2878	Part of a membrane complex involved in electron transport
J4G45_RS05265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J4G45_RS05275	COG3384	dioxygenase
J4G45_RS05285	COG2234	aminopeptidase activity
J4G45_RS05295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J4G45_RS05315	COG2186	Transcriptional regulator
J4G45_RS05325	COG0277	FAD linked oxidase domain protein
J4G45_RS05340	COG3706	GGDEF domain
J4G45_RS05360	COG0642	Histidine kinase
J4G45_RS05380	COG4372	Transposase
J4G45_RS05385	COG5002	protein histidine kinase activity
J4G45_RS05400	COG0789	Transcriptional regulator
J4G45_RS05420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
J4G45_RS05425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J4G45_RS05430	COG4680	protein conserved in bacteria
J4G45_RS05455	COG3079	Belongs to the UPF0149 family
J4G45_RS05460	COG0006	proline dipeptidase activity
J4G45_RS05470	COG3077	Addiction module antitoxin, RelB DinJ family
J4G45_RS05475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4G45_RS05480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4G45_RS05510	COG2816	NAD+ diphosphatase activity
J4G45_RS05520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4G45_RS05525	COG0741	lytic transglycosylase activity
J4G45_RS05525	COG0741	lytic transglycosylase activity
J4G45_RS05525	COG1388	LysM domain
J4G45_RS05525	COG1388	LysM domain
J4G45_RS05530	COG4166	transmembrane transport
J4G45_RS05535	COG4174	ABC transporter (Permease)
J4G45_RS05540	COG4239	(ABC) transporter, permease
J4G45_RS05545	COG4172	Belongs to the ABC transporter superfamily
J4G45_RS05575	COG0833	amino acid
J4G45_RS05590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4G45_RS05595	COG0418	dihydroorotase activity
J4G45_RS05600	COG5001	Diguanylate cyclase
J4G45_RS05600	COG4251	negative regulation of phosphorylation
J4G45_RS05600	COG3706	GGDEF domain
J4G45_RS05600	COG2203	Gaf domain
J4G45_RS05610	COG1902	pentaerythritol trinitrate reductase activity
J4G45_RS05610	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4G45_RS05635	COG2885	chlorophyll binding
J4G45_RS05640	COG0047	phosphoribosylformylglycinamidine synthase activity
J4G45_RS05640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4G45_RS05650	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J4G45_RS05660	COG0281	malic enzyme
J4G45_RS05660	COG0280	phosphate acetyltransferase
J4G45_RS05670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J4G45_RS05675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J4G45_RS05680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J4G45_RS05690	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
J4G45_RS05705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J4G45_RS05710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4G45_RS05730	COG0024	Methionine aminopeptidase
J4G45_RS05735	COG0052	Belongs to the universal ribosomal protein uS2 family
J4G45_RS05760	COG2951	lytic endotransglycosylase activity
J4G45_RS05775	COG0842	Transport permease protein
J4G45_RS05780	COG1131	(ABC) transporter
J4G45_RS05825	COG3723	Recombinational DNA repair protein, rece pathway
J4G45_RS05865	COG0305	Participates in initiation and elongation during chromosome replication
J4G45_RS05925	COG3728	DNA packaging
J4G45_RS06040	COG0582	viral genome integration into host DNA
J4G45_RS06070	COG5377	YqaJ viral recombinase family
J4G45_RS06290	COG1222	aaa ATPase
J4G45_RS06310	COG3177	Filamentation induced by cAMP protein fic
J4G45_RS06350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4G45_RS06370	COG3634	alkyl hydroperoxide reductase activity
J4G45_RS06375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4G45_RS06380	COG0826	peptidase U32
J4G45_RS06390	COG0640	Transcriptional regulator
J4G45_RS06395	COG0798	PFAM Bile acid sodium symporter
J4G45_RS06400	COG0431	NADPH-dependent FMN reductase
J4G45_RS06405	COG0789	Transcriptional regulator
J4G45_RS06430	COG1720	tRNA m6t6A37 methyltransferase activity
J4G45_RS06440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4G45_RS06455	COG0642	Histidine kinase
J4G45_RS06465	COG0352	thiamine-phosphate diphosphorylase activity
J4G45_RS06475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4G45_RS06480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J4G45_RS06485	COG3139	Protein of unknown function (DUF1315)
J4G45_RS06495	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS06505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J4G45_RS06510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J4G45_RS06530	COG0415	Belongs to the DNA photolyase family
J4G45_RS06535	COG1047	Peptidyl-prolyl cis-trans
J4G45_RS06540	COG1686	Belongs to the peptidase S11 family
J4G45_RS06560	COG0612	Peptidase, M16
J4G45_RS06595	COG0352	thiamine-phosphate diphosphorylase activity
J4G45_RS06625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J4G45_RS06625	COG1017	nitric oxide dioxygenase activity
J4G45_RS06685	COG1643	Atp-dependent helicase
J4G45_RS06705	COG0517	IMP dehydrogenase activity
J4G45_RS06705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J4G45_RS06710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J4G45_RS06720	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J4G45_RS06725	COG1137	ATPase activity
J4G45_RS06745	COG4122	O-methyltransferase activity
J4G45_RS06755	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J4G45_RS06780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4G45_RS06820	COG2011	ABC-type metal ion transport system permease component
J4G45_RS06825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4G45_RS06830	COG1464	Belongs to the NlpA lipoprotein family
J4G45_RS06835	COG0151	Belongs to the GarS family
J4G45_RS06840	COG0138	bifunctional purine biosynthesis protein purh
J4G45_RS06845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J4G45_RS06890	COG0183	Belongs to the thiolase family
J4G45_RS06910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4G45_RS06920	COG0305	Participates in initiation and elongation during chromosome replication
J4G45_RS06930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J4G45_RS06935	COG0360	Binds together with S18 to 16S ribosomal RNA
J4G45_RS06945	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J4G45_RS06950	COG1845	cytochrome c oxidase, subunit III
J4G45_RS06955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J4G45_RS06960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J4G45_RS06985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4G45_RS07000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4G45_RS07005	COG2890	protein-(glutamine-N5) methyltransferase activity
J4G45_RS07010	COG3781	membrane
J4G45_RS07030	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS07035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J4G45_RS07045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4G45_RS07055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J4G45_RS07070	COG0477	Major facilitator Superfamily
J4G45_RS07075	COG0729	surface antigen
J4G45_RS07110	COG0308	aminopeptidase N
J4G45_RS07115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4G45_RS07125	COG0589	response to stress
J4G45_RS07130	COG0589	response to stress
J4G45_RS07140	COG3135	benzoate transporter
J4G45_RS07150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J4G45_RS07165	COG0183	Belongs to the thiolase family
J4G45_RS07180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4G45_RS07185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4G45_RS07190	COG0824	Thioesterase
J4G45_RS07195	COG1454	alcohol dehydrogenase
J4G45_RS07200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4G45_RS07220	COG2197	response regulator
J4G45_RS07225	COG4585	Histidine kinase
J4G45_RS07230	COG2850	peptidyl-arginine hydroxylation
J4G45_RS07255	COG0424	maF-like protein
J4G45_RS07265	COG0126	phosphoglycerate kinase activity
J4G45_RS07290	COG0778	Nitroreductase
J4G45_RS07300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4G45_RS07310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4G45_RS07335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4G45_RS07340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J4G45_RS07345	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS07350	COG2267	carboxylic ester hydrolase activity
J4G45_RS07360	COG1902	pentaerythritol trinitrate reductase activity
J4G45_RS07360	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4G45_RS07390	COG0148	phosphopyruvate hydratase activity
J4G45_RS07395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J4G45_RS07405	COG0772	Belongs to the SEDS family
J4G45_RS07430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4G45_RS07435	COG0730	response to heat
J4G45_RS07440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4G45_RS07445	COG2207	Transcriptional regulator
J4G45_RS07450	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4G45_RS07465	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS07470	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS07505	COG4890	Cyd operon protein YbgT
J4G45_RS07510	COG1294	oxidase, subunit
J4G45_RS07525	COG1585	Membrane protein implicated in regulation of membrane protease activity
J4G45_RS07535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4G45_RS07555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4G45_RS07560	COG0569	domain protein
J4G45_RS07570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J4G45_RS07590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J4G45_RS07595	COG0542	response to heat
J4G45_RS07625	COG0372	Belongs to the citrate synthase family
J4G45_RS07640	COG1058	Belongs to the CinA family
J4G45_RS07640	COG1546	Belongs to the CinA family
J4G45_RS07690	COG2814	Major facilitator Superfamily
J4G45_RS07700	COG3706	GGDEF domain
J4G45_RS07710	COG0668	transmembrane transport
J4G45_RS07715	COG3122	Protein conserved in bacteria
J4G45_RS07720	COG3619	membrane
J4G45_RS07735	COG0640	Transcriptional regulator
J4G45_RS07740	COG2937	Belongs to the GPAT DAPAT family
J4G45_RS07745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J4G45_RS07755	COG0183	Belongs to the thiolase family
J4G45_RS07760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4G45_RS07765	COG0183	Belongs to the thiolase family
J4G45_RS07770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J4G45_RS07775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J4G45_RS07780	COG3135	benzoate transporter
J4G45_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
J4G45_RS07790	COG0633	Ferredoxin
J4G45_RS07790	COG0543	2 iron, 2 sulfur cluster binding
J4G45_RS07795	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
J4G45_RS07800	COG4638	Rieske (2fe-2S)
J4G45_RS07810	COG4829	muconolactone delta-isomerase
J4G45_RS07815	COG4948	Mandelate Racemase Muconate Lactonizing
J4G45_RS07820	COG0583	DNA-binding transcription factor activity
J4G45_RS07825	COG2814	Major facilitator Superfamily
J4G45_RS07835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4G45_RS07880	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
J4G45_RS07885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4G45_RS07915	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS07955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4G45_RS07960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
J4G45_RS07970	COG2814	Major facilitator Superfamily
J4G45_RS07985	COG1132	(ABC) transporter
J4G45_RS07995	COG2801	Transposase and inactivated derivatives
J4G45_RS08000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J4G45_RS08015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4G45_RS08020	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
J4G45_RS08030	COG1944	ATP diphosphatase activity
J4G45_RS08035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J4G45_RS08050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4G45_RS08065	COG0642	Histidine kinase
J4G45_RS08070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J4G45_RS08075	COG0511	ligase activity, forming carbon-carbon bonds
J4G45_RS08085	COG0596	Alpha beta hydrolase
J4G45_RS08115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4G45_RS08120	COG1283	sodium-dependent phosphate transmembrane transporter activity
J4G45_RS08170	COG0552	protein localization to endoplasmic reticulum
J4G45_RS08175	COG0612	Peptidase, M16
J4G45_RS08205	COG0517	IMP dehydrogenase activity
J4G45_RS08210	COG0133	tryptophan synthase activity
J4G45_RS08220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4G45_RS08240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J4G45_RS08270	COG0537	adenosine 5'-monophosphoramidase activity
J4G45_RS08295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4G45_RS08325	COG0822	iron-sulfur transferase activity
J4G45_RS08330	COG0316	Belongs to the HesB IscA family
J4G45_RS08360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4G45_RS08375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J4G45_RS08380	COG0702	epimerase
J4G45_RS08385	COG0268	Binds directly to 16S ribosomal RNA
J4G45_RS08415	COG1011	Hydrolase
J4G45_RS08420	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J4G45_RS08430	COG2137	regulation of response to DNA damage stimulus
J4G45_RS08445	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4G45_RS08465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4G45_RS08480	COG0575	Belongs to the CDS family
J4G45_RS08485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J4G45_RS08505	COG3852	Histidine kinase
J4G45_RS08520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4G45_RS08525	COG0583	DNA-binding transcription factor activity
J4G45_RS08530	COG0024	Methionine aminopeptidase
J4G45_RS08535	COG1114	Component of the transport system for branched-chain amino acids
J4G45_RS08555	COG1253	flavin adenine dinucleotide binding
J4G45_RS08575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J4G45_RS08580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J4G45_RS08595	COG2431	L-lysine efflux transmembrane transporter activity
J4G45_RS08640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J4G45_RS08675	COG0084	hydrolase, TatD family'
J4G45_RS08695	COG1663	tetraacyldisaccharide 4'-kinase activity
J4G45_RS08700	COG1132	(ABC) transporter
J4G45_RS08710	COG0811	peptide transport
J4G45_RS08715	COG1475	DNA binding
J4G45_RS08720	COG1192	Involved in chromosome partitioning
J4G45_RS08730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J4G45_RS08745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4G45_RS08790	COG1923	regulation of RNA biosynthetic process
J4G45_RS08800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J4G45_RS08805	COG0802	atpase or kinase
J4G45_RS08835	COG2707	UPF0756 membrane protein
J4G45_RS08840	COG2807	transmembrane transport
J4G45_RS08845	COG0583	DNA-binding transcription factor activity
J4G45_RS08850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4G45_RS08855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4G45_RS08865	COG1454	alcohol dehydrogenase
J4G45_RS08885	COG2353	YceI-like domain
J4G45_RS08900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J4G45_RS08905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J4G45_RS08945	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J4G45_RS08945	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4G45_RS08975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J4G45_RS09030	COG0012	GTP binding
J4G45_RS09040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
J4G45_RS09050	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J4G45_RS09055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J4G45_RS09065	COG0386	Belongs to the glutathione peroxidase family
J4G45_RS09070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4G45_RS09075	COG0436	Aminotransferase
J4G45_RS09145	COG1610	YqeY-like protein
J4G45_RS09185	COG1286	toxin biosynthetic process
J4G45_RS09190	COG0167	dihydroorotate dehydrogenase activity
J4G45_RS09215	COG0778	Nitroreductase
J4G45_RS09225	COG0513	Belongs to the DEAD box helicase family
J4G45_RS09230	COG1278	Cold shock
J4G45_RS09245	COG2363	Small membrane protein
J4G45_RS09265	COG0659	secondary active sulfate transmembrane transporter activity
J4G45_RS09270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J4G45_RS09295	COG0318	PFAM AMP-dependent synthetase and ligase
J4G45_RS09300	COG1309	transcriptional regulator
J4G45_RS09305	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS09310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J4G45_RS09315	COG1024	Enoyl-CoA hydratase
J4G45_RS09320	COG4770	biotin carboxylase activity
J4G45_RS09335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J4G45_RS09340	COG2885	chlorophyll binding
J4G45_RS09340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
J4G45_RS09350	COG0540	Belongs to the ATCase OTCase family
J4G45_RS09375	COG1765	OsmC-like protein
J4G45_RS09385	COG0667	Aldo Keto reductase
J4G45_RS09400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J4G45_RS09415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4G45_RS09420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J4G45_RS09425	COG0527	aspartate kinase activity
J4G45_RS09435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J4G45_RS09450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J4G45_RS09455	COG2252	PERMEase
J4G45_RS09485	COG0714	Associated with various cellular activities
J4G45_RS09490	COG2879	small protein
J4G45_RS09495	COG1966	Carbon starvation protein
J4G45_RS09500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J4G45_RS09505	COG1509	lysine 2,3-aminomutase activity
J4G45_RS09540	COG1067	ATP-dependent peptidase activity
J4G45_RS09545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J4G45_RS09550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4G45_RS09555	COG0583	DNA-binding transcription factor activity
J4G45_RS09580	COG1686	Belongs to the peptidase S11 family
J4G45_RS09585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J4G45_RS09605	COG2915	High frequency lysogenization protein hflD homolog
J4G45_RS09625	COG0616	signal peptide processing
J4G45_RS09635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4G45_RS09645	COG0573	inorganic phosphate transmembrane transporter activity
J4G45_RS09655	COG0076	glutamate decarboxylase activity
J4G45_RS09660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J4G45_RS09670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J4G45_RS09685	COG2814	Major facilitator Superfamily
J4G45_RS09690	COG1733	regulation of RNA biosynthetic process
J4G45_RS09710	COG0556	nucleotide-excision repair
J4G45_RS09725	COG0436	Aminotransferase
J4G45_RS09750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J4G45_RS09765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J4G45_RS09770	COG0571	ribonuclease III activity
J4G45_RS09795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4G45_RS09805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4G45_RS09820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J4G45_RS09830	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J4G45_RS09845	COG4208	sulfate ABC transporter
J4G45_RS09850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J4G45_RS09855	COG0583	DNA-binding transcription factor activity
J4G45_RS09865	COG4625	pathogenesis
J4G45_RS09880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J4G45_RS09890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J4G45_RS09895	COG1056	cytidyltransferase-related domain
J4G45_RS09895	COG1051	belongs to the nudix hydrolase family
J4G45_RS09900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J4G45_RS09905	COG0778	Nitroreductase
J4G45_RS09920	COG0632	four-way junction helicase activity
J4G45_RS09925	COG2255	four-way junction helicase activity
J4G45_RS09935	COG0824	Thioesterase
J4G45_RS09955	COG0823	Involved in the tonB-independent uptake of proteins
J4G45_RS09975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4G45_RS10005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J4G45_RS10010	COG0628	permease
J4G45_RS10015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J4G45_RS10020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4G45_RS10040	COG2333	competence protein COMEC
J4G45_RS10040	COG0658	competence protein
J4G45_RS10050	COG1136	(ABC) transporter
J4G45_RS10055	COG4591	ABC-type transport system involved in lipoprotein release permease component
J4G45_RS10070	COG1671	Belongs to the UPF0178 family
J4G45_RS10110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4G45_RS10150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J4G45_RS10165	COG0019	diaminopimelate decarboxylase activity
J4G45_RS10175	COG1115	amino acid carrier protein
J4G45_RS10190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4G45_RS10195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J4G45_RS10200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J4G45_RS10235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J4G45_RS10245	COG0174	glutamine synthetase
J4G45_RS10250	COG0512	Glutamine amidotransferase of anthranilate synthase
J4G45_RS10255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4G45_RS10270	COG0302	gtp cyclohydrolase
J4G45_RS10275	COG3706	GGDEF domain
J4G45_RS10290	COG3739	integral membrane protein
J4G45_RS10305	COG1741	Belongs to the pirin family
J4G45_RS10310	COG2072	flavoprotein involved in K transport
J4G45_RS10325	COG2871	sodium ion transport
J4G45_RS10395	COG0175	sulfate reduction
J4G45_RS10405	COG3549	Plasmid maintenance system killer
J4G45_RS10410	COG3093	addiction module antidote protein HigA
J4G45_RS10425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4G45_RS10430	COG1773	rubredoxin
J4G45_RS10435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4G45_RS10440	COG2267	carboxylic ester hydrolase activity
J4G45_RS10445	COG0583	DNA-binding transcription factor activity
J4G45_RS10460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4G45_RS10465	COG0705	Rhomboid family
J4G45_RS10465	COG0457	Tetratricopeptide repeat
J4G45_RS10470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
J4G45_RS10475	COG4181	ATPase activity
J4G45_RS10520	COG0306	phosphate transporter
J4G45_RS10545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4G45_RS10565	COG1196	nuclear chromosome segregation
J4G45_RS10565	COG0741	lytic transglycosylase activity
J4G45_RS10565	COG0739	heme binding
J4G45_RS10570	COG0501	Belongs to the peptidase M48B family
J4G45_RS10580	COG2239	Acts as a magnesium transporter
J4G45_RS10600	COG0459	protein refolding
J4G45_RS10610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J4G45_RS10615	COG1597	lipid kinase activity
J4G45_RS10635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J4G45_RS10675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J4G45_RS10680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4G45_RS10705	COG0505	Belongs to the CarA family
J4G45_RS10730	COG0589	response to stress
J4G45_RS10735	COG3695	enzyme binding
J4G45_RS10740	COG2321	neutral zinc metallopeptidase
J4G45_RS10745	COG2354	Protein conserved in bacteria
J4G45_RS10755	COG1649	PFAM Uncharacterised BCR, COG1649
J4G45_RS10755	COG0726	polysaccharide deacetylase
J4G45_RS10765	COG1215	transferase activity, transferring glycosyl groups
J4G45_RS10770	COG0726	polysaccharide deacetylase
J4G45_RS10770	COG1649	PFAM Uncharacterised BCR, COG1649
J4G45_RS10790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4G45_RS10805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J4G45_RS10810	COG1053	succinate dehydrogenase
J4G45_RS10815	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J4G45_RS10835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4G45_RS10835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J4G45_RS10860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4G45_RS10885	COG0564	pseudouridine synthase activity
J4G45_RS10895	COG0358	DNA primase activity
J4G45_RS10900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J4G45_RS10910	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J4G45_RS10940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4G45_RS10965	COG1054	Belongs to the UPF0176 family
J4G45_RS10975	COG0586	Pfam SNARE associated Golgi protein
J4G45_RS11010	COG0321	lipoyl(octanoyl) transferase activity
J4G45_RS11025	COG0531	amino acid
J4G45_RS11030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J4G45_RS11035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J4G45_RS11035	COG1648	precorrin-2 dehydrogenase activity
J4G45_RS11040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J4G45_RS11050	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J4G45_RS11075	COG0671	phosphoesterase, PA-phosphatase related
J4G45_RS11080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4G45_RS11085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4G45_RS11090	COG1538	Outer membrane efflux protein
J4G45_RS11095	COG0393	Putative heavy-metal-binding
J4G45_RS11100	COG0393	Putative heavy-metal-binding
J4G45_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
J4G45_RS11125	COG0525	valine-tRNA ligase activity
J4G45_RS11135	COG2826	transposase and inactivated derivatives, IS30 family
J4G45_RS11145	COG2852	Protein conserved in bacteria
J4G45_RS11150	COG2323	membrane
J4G45_RS11165	COG1752	Esterase of the alpha-beta hydrolase superfamily
J4G45_RS11180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4G45_RS11185	COG2205	protein histidine kinase activity
J4G45_RS11190	COG0745	RESPONSE REGULATOR receiver
J4G45_RS11200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4G45_RS11215	COG1652	LysM domain
J4G45_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
J4G45_RS11240	COG1399	metal-binding, possibly nucleic acid-binding protein
J4G45_RS11245	COG3101	peptidyl-lysine hydroxylation
J4G45_RS11250	COG0009	L-threonylcarbamoyladenylate synthase
J4G45_RS11260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J4G45_RS11265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J4G45_RS11280	COG4106	trans-aconitate 2-methyltransferase activity
J4G45_RS11295	COG0596	Alpha beta hydrolase
J4G45_RS11295	COG2226	methyltransferase
J4G45_RS11295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4G45_RS11300	COG2193	ferroxidase activity
J4G45_RS11305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4G45_RS11310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J4G45_RS11315	COG3115	cell septum assembly
J4G45_RS11320	COG1196	nuclear chromosome segregation
J4G45_RS11330	COG0730	response to heat
J4G45_RS11345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4G45_RS11355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4G45_RS11365	COG3422	double-strand break repair
J4G45_RS11370	COG2824	Alkylphosphonate utilization operon protein PhnA
J4G45_RS11375	COG3189	MarR family transcriptional regulator
J4G45_RS11390	COG0564	pseudouridine synthase activity
J4G45_RS11415	COG1487	ribonuclease activity
J4G45_RS11420	COG4456	Virulence-associated protein
J4G45_RS11425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J4G45_RS11430	COG0354	folic acid binding
J4G45_RS11445	COG0675	Transposase, IS605 OrfB family
J4G45_RS11455	COG1902	pentaerythritol trinitrate reductase activity
J4G45_RS11465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4G45_RS11470	COG1970	mechanosensitive ion channel activity
J4G45_RS11475	COG1217	gtp-binding protein TYPA
J4G45_RS11480	COG2233	PERMEase
J4G45_RS11490	COG0833	amino acid
J4G45_RS11505	COG0183	Belongs to the thiolase family
J4G45_RS11520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4G45_RS11525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J4G45_RS11530	COG2207	Transcriptional regulator
J4G45_RS11535	COG0183	Belongs to the thiolase family
J4G45_RS11540	COG1024	Enoyl-CoA hydratase
J4G45_RS11540	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4G45_RS11560	COG1272	protein, Hemolysin III
J4G45_RS11565	COG0477	Major facilitator Superfamily
J4G45_RS11570	COG1408	metallophosphoesterase
J4G45_RS11575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4G45_RS11585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4G45_RS11615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J4G45_RS11620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J4G45_RS11640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J4G45_RS11645	COG0625	glutathione transferase activity
J4G45_RS11650	COG2969	positive regulation of protein catabolic process
J4G45_RS11690	COG3300	MHYT domain
J4G45_RS11690	COG5001	Diguanylate cyclase
J4G45_RS11695	COG2885	chlorophyll binding
J4G45_RS11720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J4G45_RS11725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J4G45_RS11740	COG0450	alkyl hydroperoxide reductase
J4G45_RS11750	COG0285	dihydrofolate synthase activity
J4G45_RS11755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J4G45_RS11775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J4G45_RS11780	COG1162	GTPase activity
J4G45_RS11790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J4G45_RS11800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4G45_RS11810	COG3781	membrane
J4G45_RS11825	COG2350	Protein conserved in bacteria
J4G45_RS11855	COG1607	acyl-coa hydrolase
J4G45_RS11885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4G45_RS11920	COG1183	phosphatidylcholine synthase activity
J4G45_RS11925	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J4G45_RS11950	COG2391	methyltransferase activity
J4G45_RS11965	COG1196	nuclear chromosome segregation
J4G45_RS11965	COG0739	heme binding
J4G45_RS11965	COG0741	lytic transglycosylase activity
J4G45_RS11970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4G45_RS11975	COG1702	phosphate starvation-inducible protein PhoH
J4G45_RS11980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J4G45_RS12020	COG1295	ribonuclease BN
J4G45_RS12045	COG0788	formyltetrahydrofolate deformylase activity
J4G45_RS12070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J4G45_RS12070	COG4651	solute:proton antiporter activity
J4G45_RS12085	COG0724	RNA recognition motif
J4G45_RS12115	COG2900	Belongs to the SlyX family
J4G45_RS12120	COG0488	(ABC) transporter
J4G45_RS12125	COG1560	Kdo2-lipid A biosynthetic process
J4G45_RS12155	COG0252	asparaginase activity
J4G45_RS12160	COG0101	tRNA pseudouridine synthase activity
J4G45_RS12180	COG0473	3-isopropylmalate dehydrogenase activity
J4G45_RS12195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J4G45_RS12210	COG0583	DNA-binding transcription factor activity
J4G45_RS12245	COG1960	acyl-CoA dehydrogenase activity
J4G45_RS12255	COG0753	catalase activity
J4G45_RS12270	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4G45_RS12275	COG3384	dioxygenase
J4G45_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
J4G45_RS12295	COG4638	Rieske (2fe-2S)
J4G45_RS12300	COG0583	DNA-binding transcription factor activity
J4G45_RS12325	COG4569	acetaldehyde dehydrogenase (acetylating) activity
J4G45_RS12330	COG3971	2-oxopent-4-enoate hydratase activity
J4G45_RS12335	COG0546	phosphoglycolate phosphatase activity
J4G45_RS12345	COG1530	ribonuclease E activity
J4G45_RS12350	COG0318	PFAM AMP-dependent synthetase and ligase
J4G45_RS12375	COG1983	PspC domain protein
J4G45_RS12380	COG0517	IMP dehydrogenase activity
J4G45_RS12390	COG0751	glycine-tRNA ligase activity
J4G45_RS12420	COG2226	methyltransferase
J4G45_RS12430	COG0493	'glutamate synthase
J4G45_RS12440	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J4G45_RS12445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4G45_RS12460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J4G45_RS12470	COG0644	oxidoreductase
J4G45_RS12470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
J4G45_RS12495	COG4535	Mg2 and Co2 transporter CorC
J4G45_RS12500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
J4G45_RS12515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4G45_RS12525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J4G45_RS12565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4G45_RS12570	COG1074	ATP-dependent DNA helicase activity
J4G45_RS12575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J4G45_RS12595	COG2226	methyltransferase
J4G45_RS12605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J4G45_RS12630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4G45_RS12630	COG2111	Na H antiporter
J4G45_RS12635	COG1006	Multisubunit Na H antiporter MnhC subunit
J4G45_RS12640	COG0651	ATP synthesis coupled electron transport
J4G45_RS12645	COG1863	multisubunit Na H antiporter MnhE subunit
J4G45_RS12650	COG2212	antiporter activity
J4G45_RS12655	COG1320	monovalent cation:proton antiporter activity
J4G45_RS12660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J4G45_RS12665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J4G45_RS12670	COG0195	Participates in both transcription termination and antitermination
J4G45_RS12675	COG0779	Required for maturation of 30S ribosomal subunits
J4G45_RS12725	COG0237	dephospho-CoA kinase activity
J4G45_RS12735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4G45_RS12740	COG3123	guanosine phosphorylase activity
J4G45_RS12745	COG0497	DNA recombination
J4G45_RS12775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J4G45_RS12790	COG1132	(ABC) transporter
J4G45_RS12795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J4G45_RS12805	COG0322	excinuclease ABC activity
J4G45_RS12825	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4G45_RS12825	COG1024	Enoyl-CoA hydratase
J4G45_RS12845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J4G45_RS12875	COG0326	Molecular chaperone. Has ATPase activity
J4G45_RS12885	COG3047	cAMP biosynthetic process
J4G45_RS12890	COG2056	Na+-H+ antiporter family
J4G45_RS12925	COG0085	RNA polymerase activity
J4G45_RS12940	COG0081	regulation of translation
J4G45_RS13025	COG0824	Thioesterase
J4G45_RS13045	COG0181	hydroxymethylbilane synthase activity
J4G45_RS13055	COG3275	phosphorelay sensor kinase activity
J4G45_RS13060	COG0165	Argininosuccinate lyase
J4G45_RS13075	COG1538	Outer membrane efflux protein
J4G45_RS13090	COG0494	nUDIX hydrolase
J4G45_RS13095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J4G45_RS13100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J4G45_RS13105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4G45_RS13115	COG0772	Belongs to the SEDS family
J4G45_RS13140	COG4974	Belongs to the 'phage' integrase family
J4G45_RS13145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J4G45_RS13155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J4G45_RS13165	COG2197	response regulator
J4G45_RS13180	COG0793	Belongs to the peptidase S41A family
J4G45_RS13185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J4G45_RS13190	COG0795	lipopolysaccharide-transporting ATPase activity
J4G45_RS13195	COG0795	lipopolysaccharide-transporting ATPase activity
J4G45_RS13220	COG0586	Pfam SNARE associated Golgi protein
J4G45_RS13235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4G45_RS13235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4G45_RS13245	COG0004	ammonium transporteR
J4G45_RS13250	COG0347	Belongs to the P(II) protein family
J4G45_RS13260	COG0606	chelatase, subunit chli
J4G45_RS13280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J4G45_RS13295	COG0318	PFAM AMP-dependent synthetase and ligase
J4G45_RS13305	COG0477	Major facilitator Superfamily
J4G45_RS13310	COG2860	membrane
J4G45_RS13315	COG3012	SEC-C Motif Domain Protein
J4G45_RS13320	COG1253	flavin adenine dinucleotide binding
J4G45_RS13355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4G45_RS13375	COG2814	Major facilitator Superfamily
J4G45_RS13380	COG2814	Major facilitator Superfamily
J4G45_RS13430	COG0758	DNA mediated transformation
J4G45_RS13435	COG0009	L-threonylcarbamoyladenylate synthase
J4G45_RS13450	COG0697	spore germination
J4G45_RS13455	COG0386	Belongs to the glutathione peroxidase family
J4G45_RS13470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J4G45_RS13520	COG1121	(ABC) transporter
J4G45_RS13525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4G45_RS13540	COG2837	iron assimilation
J4G45_RS13565	COG2826	transposase and inactivated derivatives, IS30 family
J4G45_RS13620	COG2814	Major facilitator Superfamily
J4G45_RS13630	COG0352	thiamine-phosphate diphosphorylase activity
J4G45_RS13630	COG0351	phosphomethylpyrimidine kinase
J4G45_RS13630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J4G45_RS13660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4G45_RS13665	COG3162	membrane