locus-tag	class	description
LZG54_RS00010	COG0592	DNA-directed DNA polymerase activity
LZG54_RS00020	COG0187	DNA topoisomerase II activity
LZG54_RS00035	COG0488	(ABC) transporter
LZG54_RS00050	COG0316	Belongs to the HesB IscA family
LZG54_RS00055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LZG54_RS00060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LZG54_RS00095	COG1047	Peptidyl-prolyl cis-trans
LZG54_RS00105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LZG54_RS00110	COG0196	riboflavin kinase activity
LZG54_RS00120	COG1309	transcriptional regulator
LZG54_RS00125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LZG54_RS00125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LZG54_RS00150	COG1028	Short-chain dehydrogenase reductase Sdr
LZG54_RS00155	COG0546	phosphoglycolate phosphatase activity
LZG54_RS00160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LZG54_RS00175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LZG54_RS00190	COG3023	N-Acetylmuramoyl-L-alanine amidase
LZG54_RS00210	COG1064	alcohol dehydrogenase
LZG54_RS00215	COG2818	Glycosylase
LZG54_RS00230	COG1194	a g-specific adenine glycosylase
LZG54_RS00245	COG5487	UPF0391 membrane protein
LZG54_RS00250	COG2983	Belongs to the UPF0260 family
LZG54_RS00255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LZG54_RS00265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LZG54_RS00275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LZG54_RS00285	COG1335	isochorismatase
LZG54_RS00300	COG0560	Phosphoserine phosphatase
LZG54_RS00300	COG3830	Belongs to the UPF0237 family
LZG54_RS00360	COG0534	Mate efflux family protein
LZG54_RS00365	COG0436	Aminotransferase
LZG54_RS00370	COG2733	membrane
LZG54_RS00385	COG2918	glutathione biosynthetic process
LZG54_RS00400	COG3150	esterase
LZG54_RS00410	COG0471	metal ion transport
LZG54_RS00465	COG1393	Belongs to the ArsC family
LZG54_RS00470	COG0708	Exodeoxyribonuclease III
LZG54_RS00475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LZG54_RS00485	COG0189	ligase activity
LZG54_RS00505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LZG54_RS00515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LZG54_RS00520	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LZG54_RS00545	COG2119	membrane
LZG54_RS00550	COG0426	domain, Protein
LZG54_RS00550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LZG54_RS00565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LZG54_RS00575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LZG54_RS00600	COG1902	pentaerythritol trinitrate reductase activity
LZG54_RS00605	COG1519	Transferase
LZG54_RS00615	COG0668	transmembrane transport
LZG54_RS00620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LZG54_RS00665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZG54_RS00675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LZG54_RS00680	COG2808	Putative FMN-binding domain
LZG54_RS00690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LZG54_RS00695	COG0235	Class ii aldolase
LZG54_RS00735	COG4372	Transposase
LZG54_RS00760	COG2826	transposase and inactivated derivatives, IS30 family
LZG54_RS00785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZG54_RS00795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LZG54_RS00800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LZG54_RS00805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LZG54_RS00835	COG3177	Filamentation induced by cAMP protein fic
LZG54_RS00850	COG2826	transposase and inactivated derivatives, IS30 family
LZG54_RS00855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LZG54_RS00895	COG3293	Transposase
LZG54_RS00940	COG2826	transposase and inactivated derivatives, IS30 family
LZG54_RS00970	COG0582	viral genome integration into host DNA
LZG54_RS00980	COG3158	transport of potassium into the cell
LZG54_RS01025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LZG54_RS01040	COG0697	spore germination
LZG54_RS01060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LZG54_RS01095	COG0427	acetyl-CoA hydrolase
LZG54_RS01110	COG2183	response to ionizing radiation
LZG54_RS01120	COG4221	oxidoreductase activity
LZG54_RS01130	COG0488	(ABC) transporter
LZG54_RS01150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LZG54_RS01165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LZG54_RS01170	COG0275	rRNA processing
LZG54_RS01185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LZG54_RS01190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LZG54_RS01195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LZG54_RS01200	COG2226	methyltransferase
LZG54_RS01255	COG0493	'glutamate synthase
LZG54_RS01260	COG1704	LemA family
LZG54_RS01265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LZG54_RS01295	COG0463	Glycosyl transferase, family 2
LZG54_RS01315	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LZG54_RS01320	COG2826	transposase and inactivated derivatives, IS30 family
LZG54_RS01340	COG3307	-O-antigen
LZG54_RS01345	COG3609	addiction module antidote protein, CC2985 family
LZG54_RS01365	COG2906	2 iron, 2 sulfur cluster binding
LZG54_RS01375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZG54_RS01380	COG1758	RNA polymerase activity
LZG54_RS01385	COG0194	GDP metabolic process
LZG54_RS01430	COG0228	four-way junction DNA binding
LZG54_RS01435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LZG54_RS01445	COG0335	large ribosomal subunit rRNA binding
LZG54_RS01460	COG5380	lipid catabolic process
LZG54_RS01465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LZG54_RS01480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZG54_RS01485	COG0277	FAD linked oxidase domain protein
LZG54_RS01505	COG2814	Major facilitator Superfamily
LZG54_RS01510	COG2032	superoxide dismutase activity
LZG54_RS01515	COG0628	permease
LZG54_RS01520	COG1192	Involved in chromosome partitioning
LZG54_RS01530	COG2226	methyltransferase
LZG54_RS01545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LZG54_RS01550	COG0254	rRNA binding
LZG54_RS01555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZG54_RS01560	COG0534	Mate efflux family protein
LZG54_RS01570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LZG54_RS01575	COG1960	acyl-CoA dehydrogenase activity
LZG54_RS01590	COG0408	coproporphyrinogen oxidase activity
LZG54_RS01595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LZG54_RS01615	COG0513	Belongs to the DEAD box helicase family
LZG54_RS01620	COG1127	ABC transporter
LZG54_RS01625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LZG54_RS01630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LZG54_RS01635	COG2854	intermembrane phospholipid transfer
LZG54_RS01645	COG0598	Magnesium transport protein CorA
LZG54_RS01660	COG1040	competence protein
LZG54_RS01665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LZG54_RS01675	COG2937	Belongs to the GPAT DAPAT family
LZG54_RS01680	COG1946	Acyl-CoA thioesterase
LZG54_RS01685	COG1301	dicarboxylic acid transport
LZG54_RS01700	COG1959	2 iron, 2 sulfur cluster binding
LZG54_RS01710	COG0433	COG0433 Predicted ATPase
LZG54_RS01730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LZG54_RS01735	COG0088	Forms part of the polypeptide exit tunnel
LZG54_RS01750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LZG54_RS01790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LZG54_RS01800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LZG54_RS01805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LZG54_RS01815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LZG54_RS01840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LZG54_RS01850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LZG54_RS01860	COG0203	ribosomal protein L17
LZG54_RS01865	COG2072	flavoprotein involved in K transport
LZG54_RS01870	COG1960	acyl-CoA dehydrogenase activity
LZG54_RS01875	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LZG54_RS01910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LZG54_RS01915	COG0339	signal peptide processing
LZG54_RS01920	COG0557	exoribonuclease II activity
LZG54_RS01950	COG0179	Fumarylacetoacetate (FAA) hydrolase
LZG54_RS01975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LZG54_RS02015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LZG54_RS02030	COG2813	Specifically methylates the guanine in position
LZG54_RS02030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZG54_RS02035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZG54_RS02040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LZG54_RS02050	COG3128	pkhd-type hydroxylase
LZG54_RS02060	COG4771	TonB-dependent receptor
LZG54_RS02070	COG0740	serine-type endopeptidase activity
LZG54_RS02085	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LZG54_RS02085	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LZG54_RS02095	COG0857	belongs to the CobB CobQ family
LZG54_RS02095	COG0280	phosphate acetyltransferase
LZG54_RS02100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LZG54_RS02115	COG2267	carboxylic ester hydrolase activity
LZG54_RS02145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LZG54_RS02160	COG0084	hydrolase, TatD family'
LZG54_RS02165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LZG54_RS02170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LZG54_RS02180	COG2814	Major facilitator Superfamily
LZG54_RS02210	COG3622	Belongs to the hyi family
LZG54_RS02215	COG2084	Dehydrogenase
LZG54_RS02220	COG1024	Enoyl-CoA hydratase
LZG54_RS02225	COG5002	protein histidine kinase activity
LZG54_RS02225	COG0784	Response regulator, receiver
LZG54_RS02225	COG2205	protein histidine kinase activity
LZG54_RS02245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZG54_RS02265	COG1862	Preprotein translocase
LZG54_RS02275	COG3706	GGDEF domain
LZG54_RS02275	COG4251	negative regulation of phosphorylation
LZG54_RS02275	COG5001	Diguanylate cyclase
LZG54_RS02275	COG2203	Gaf domain
LZG54_RS02280	COG1704	LemA family
LZG54_RS02290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LZG54_RS02310	COG0784	Response regulator, receiver
LZG54_RS02310	COG5002	protein histidine kinase activity
LZG54_RS02310	COG2205	protein histidine kinase activity
LZG54_RS02315	COG1538	Outer membrane efflux protein
LZG54_RS02320	COG1136	(ABC) transporter
LZG54_RS02320	COG0577	efflux transmembrane transporter activity
LZG54_RS02325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZG54_RS02330	COG2703	oxygen carrier activity
LZG54_RS02355	COG0028	Belongs to the TPP enzyme family
LZG54_RS02385	COG0726	polysaccharide deacetylase
LZG54_RS02390	COG0463	Glycosyl transferase, family 2
LZG54_RS02395	COG0438	transferase activity, transferring glycosyl groups
LZG54_RS02405	COG0438	transferase activity, transferring glycosyl groups
LZG54_RS02420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LZG54_RS02435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZG54_RS02455	COG1960	acyl-CoA dehydrogenase activity
LZG54_RS02460	COG1960	acyl-CoA dehydrogenase activity
LZG54_RS02470	COG2205	protein histidine kinase activity
LZG54_RS02475	COG0745	RESPONSE REGULATOR receiver
LZG54_RS02480	COG2315	Protein conserved in bacteria
LZG54_RS02485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LZG54_RS02500	COG2096	Adenosyltransferase
LZG54_RS02505	COG4206	TonB-dependent receptor
LZG54_RS02535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LZG54_RS02580	COG2975	iron-sulfur cluster assembly
LZG54_RS02600	COG1426	Protein conserved in bacteria
LZG54_RS02620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZG54_RS02635	COG3956	TIGRFAM MazG family protein
LZG54_RS02640	COG1596	polysaccharide export
LZG54_RS02640	COG1555	photosystem II stabilization
LZG54_RS02645	COG0617	tRNA 3'-terminal CCA addition
LZG54_RS02650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LZG54_RS02665	COG1660	Displays ATPase and GTPase activities
LZG54_RS02675	COG3028	Belongs to the UPF0307 family
LZG54_RS02680	COG0318	PFAM AMP-dependent synthetase and ligase
LZG54_RS02690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LZG54_RS02705	COG0625	glutathione transferase activity
LZG54_RS02715	COG1238	metal cluster binding
LZG54_RS02760	COG2314	TM2 domain
LZG54_RS02770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LZG54_RS02775	COG0072	phenylalanine-tRNA ligase activity
LZG54_RS02800	COG0248	Ppx GppA phosphatase
LZG54_RS02810	COG0037	tRNA processing
LZG54_RS02860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZG54_RS02940	COG1607	acyl-coa hydrolase
LZG54_RS02970	COG2350	Protein conserved in bacteria
LZG54_RS02980	COG0613	PHP domain protein
LZG54_RS02985	COG3781	membrane
LZG54_RS02990	COG2003	Belongs to the UPF0758 family
LZG54_RS02995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LZG54_RS03005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LZG54_RS03015	COG1162	GTPase activity
LZG54_RS03020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LZG54_RS03040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LZG54_RS03045	COG0285	dihydrofolate synthase activity
LZG54_RS03060	COG0450	alkyl hydroperoxide reductase
LZG54_RS03075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LZG54_RS03080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LZG54_RS03155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LZG54_RS03160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LZG54_RS03210	COG0494	nUDIX hydrolase
LZG54_RS03220	COG1214	PFAM Peptidase M22, glycoprotease
LZG54_RS03225	COG1968	undecaprenyl-diphosphatase activity
LZG54_RS03245	COG4269	membrane
LZG54_RS03260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LZG54_RS03270	COG2132	Multicopper oxidase
LZG54_RS03285	COG2076	Multidrug Resistance protein
LZG54_RS03290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LZG54_RS03300	COG0352	thiamine-phosphate diphosphorylase activity
LZG54_RS03300	COG0351	phosphomethylpyrimidine kinase
LZG54_RS03315	COG1981	membrane
LZG54_RS03355	COG0456	acetyltransferase
LZG54_RS03365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LZG54_RS03370	COG0492	ferredoxin-NADP+ reductase activity
LZG54_RS03375	COG1674	ftsk spoiiie
LZG54_RS03375	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LZG54_RS03390	COG2894	cell division
LZG54_RS03405	COG0204	Acyl-transferase
LZG54_RS03410	COG2885	chlorophyll binding
LZG54_RS03415	COG0210	DNA helicase
LZG54_RS03420	COG0756	dUTP diphosphatase activity
LZG54_RS03425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LZG54_RS03430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LZG54_RS03440	COG0121	glutamine amidotransferase
LZG54_RS03455	COG2914	Belongs to the UPF0125 (RnfH) family
LZG54_RS03460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZG54_RS03465	COG0735	belongs to the Fur family
LZG54_RS03495	COG0420	3'-5' exonuclease activity
LZG54_RS03505	COG1090	epimerase
LZG54_RS03510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZG54_RS03520	COG2050	protein possibly involved in aromatic compounds catabolism
LZG54_RS03525	COG4774	siderophore transport
LZG54_RS03540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LZG54_RS03555	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LZG54_RS03580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LZG54_RS03590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LZG54_RS03595	COG1077	Cell shape determining protein MreB Mrl
LZG54_RS03600	COG1792	Involved in formation and maintenance of cell shape
LZG54_RS03605	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LZG54_RS03610	COG0424	maF-like protein
LZG54_RS03615	COG1530	ribonuclease E activity
LZG54_RS03625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZG54_RS03635	COG0560	Phosphoserine phosphatase
LZG54_RS03655	COG1840	ABC-type Fe3 transport system, periplasmic component
LZG54_RS03660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LZG54_RS03665	COG1113	amino acid transport
LZG54_RS03670	COG2828	Protein conserved in bacteria
LZG54_RS03675	COG0142	geranyltranstransferase activity
LZG54_RS03685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZG54_RS03695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZG54_RS03695	COG0649	NAD binding
LZG54_RS03705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LZG54_RS03720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZG54_RS03730	COG0713	ATP synthesis coupled electron transport
LZG54_RS03735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LZG54_RS03740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZG54_RS03750	COG4372	Transposase
LZG54_RS03770	COG1278	Cold shock
LZG54_RS03775	COG1278	Cold shock
LZG54_RS03780	COG0583	DNA-binding transcription factor activity
LZG54_RS03800	COG0668	transmembrane transport
LZG54_RS03810	COG2081	HI0933 family
LZG54_RS03815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LZG54_RS03830	COG4716	Myosin-crossreactive antigen
LZG54_RS03840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZG54_RS03850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZG54_RS03850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZG54_RS03855	COG0489	protein tyrosine kinase activity
LZG54_RS03935	COG0840	transmembrane signaling receptor activity
LZG54_RS03940	COG0643	Histidine kinase
LZG54_RS03940	COG2198	Histidine kinase
LZG54_RS03950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LZG54_RS03955	COG5510	response to toxic substance
LZG54_RS03965	COG2832	Protein of unknown function (DUF454)
LZG54_RS03970	COG1376	ErfK ybiS ycfS ynhG family protein
LZG54_RS04035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LZG54_RS04045	COG1289	transmembrane transporter activity
LZG54_RS04050	COG2814	Major facilitator Superfamily
LZG54_RS04060	COG0786	glutamate:sodium symporter activity
LZG54_RS04070	COG1752	Esterase of the alpha-beta hydrolase superfamily
LZG54_RS04080	COG1607	acyl-coa hydrolase
LZG54_RS04090	COG0523	cobalamin synthesis protein
LZG54_RS04095	COG4681	YaeQ
LZG54_RS04105	COG2203	Gaf domain
LZG54_RS04105	COG2199	diguanylate cyclase activity
LZG54_RS04125	COG1253	flavin adenine dinucleotide binding
LZG54_RS04150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LZG54_RS04155	COG0742	ribosomal rna small subunit methyltransferase
LZG54_RS04160	COG0768	penicillin binding
LZG54_RS04185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LZG54_RS04190	COG2878	Part of a membrane complex involved in electron transport
LZG54_RS04195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LZG54_RS04200	COG3384	dioxygenase
LZG54_RS04210	COG2234	aminopeptidase activity
LZG54_RS04220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LZG54_RS04230	COG2186	Transcriptional regulator
LZG54_RS04240	COG0277	FAD linked oxidase domain protein
LZG54_RS04270	COG0642	Histidine kinase
LZG54_RS04275	COG0745	RESPONSE REGULATOR receiver
LZG54_RS04280	COG2194	sulfuric ester hydrolase activity
LZG54_RS04295	COG0789	Transcriptional regulator
LZG54_RS04315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LZG54_RS04320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LZG54_RS04325	COG4680	protein conserved in bacteria
LZG54_RS04350	COG3079	Belongs to the UPF0149 family
LZG54_RS04355	COG0006	proline dipeptidase activity
LZG54_RS04360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZG54_RS04365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZG54_RS04395	COG2816	NAD+ diphosphatase activity
LZG54_RS04405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZG54_RS04410	COG1388	LysM domain
LZG54_RS04410	COG1388	LysM domain
LZG54_RS04410	COG0741	lytic transglycosylase activity
LZG54_RS04410	COG0741	lytic transglycosylase activity
LZG54_RS04415	COG4166	transmembrane transport
LZG54_RS04420	COG4174	ABC transporter (Permease)
LZG54_RS04425	COG4239	(ABC) transporter, permease
LZG54_RS04430	COG4172	Belongs to the ABC transporter superfamily
LZG54_RS04460	COG0833	amino acid
LZG54_RS04475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZG54_RS04480	COG0418	dihydroorotase activity
LZG54_RS04485	COG5001	Diguanylate cyclase
LZG54_RS04485	COG2203	Gaf domain
LZG54_RS04485	COG4251	negative regulation of phosphorylation
LZG54_RS04485	COG3706	GGDEF domain
LZG54_RS04495	COG1902	pentaerythritol trinitrate reductase activity
LZG54_RS04495	COG0446	pyridine nucleotide-disulphide oxidoreductase
LZG54_RS04510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZG54_RS04525	COG0047	phosphoribosylformylglycinamidine synthase activity
LZG54_RS04525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LZG54_RS04550	COG5001	Diguanylate cyclase
LZG54_RS04550	COG3300	MHYT domain
LZG54_RS04555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LZG54_RS04560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LZG54_RS04565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LZG54_RS04575	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LZG54_RS04595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LZG54_RS04600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZG54_RS04625	COG0052	Belongs to the universal ribosomal protein uS2 family
LZG54_RS04650	COG2951	lytic endotransglycosylase activity
LZG54_RS04665	COG0842	Transport permease protein
LZG54_RS04670	COG1131	(ABC) transporter
LZG54_RS04680	COG0582	viral genome integration into host DNA
LZG54_RS04725	COG2184	nucleotidyltransferase activity
LZG54_RS04735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LZG54_RS04745	COG4804	nuclease activity
LZG54_RS04780	COG0640	Transcriptional regulator
LZG54_RS04790	COG0798	PFAM Bile acid sodium symporter
LZG54_RS04795	COG0431	NADPH-dependent FMN reductase
LZG54_RS04805	COG3177	Filamentation induced by cAMP protein fic
LZG54_RS04845	COG3293	Transposase
LZG54_RS04885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZG54_RS04905	COG3634	alkyl hydroperoxide reductase activity
LZG54_RS04910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LZG54_RS04915	COG0826	peptidase U32
LZG54_RS04925	COG0640	Transcriptional regulator
LZG54_RS04945	COG0431	NADPH-dependent FMN reductase
LZG54_RS04950	COG0789	Transcriptional regulator
LZG54_RS04975	COG1720	tRNA m6t6A37 methyltransferase activity
LZG54_RS04990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LZG54_RS05005	COG0642	Histidine kinase
LZG54_RS05015	COG0352	thiamine-phosphate diphosphorylase activity
LZG54_RS05025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LZG54_RS05030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LZG54_RS05035	COG3139	Protein of unknown function (DUF1315)
LZG54_RS05055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LZG54_RS05060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LZG54_RS05075	COG0415	Belongs to the DNA photolyase family
LZG54_RS05080	COG1047	Peptidyl-prolyl cis-trans
LZG54_RS05085	COG1686	Belongs to the peptidase S11 family
LZG54_RS05110	COG0612	Peptidase, M16
LZG54_RS05145	COG0352	thiamine-phosphate diphosphorylase activity
LZG54_RS05175	COG1017	nitric oxide dioxygenase activity
LZG54_RS05175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LZG54_RS05235	COG1643	Atp-dependent helicase
LZG54_RS05255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LZG54_RS05255	COG0517	IMP dehydrogenase activity
LZG54_RS05260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LZG54_RS05270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LZG54_RS05275	COG1137	ATPase activity
LZG54_RS05295	COG4122	O-methyltransferase activity
LZG54_RS05305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LZG54_RS05345	COG2011	ABC-type metal ion transport system permease component
LZG54_RS05350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LZG54_RS05355	COG1464	Belongs to the NlpA lipoprotein family
LZG54_RS05365	COG0138	bifunctional purine biosynthesis protein purh
LZG54_RS05370	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LZG54_RS05415	COG0183	Belongs to the thiolase family
LZG54_RS05430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LZG54_RS05440	COG0305	Participates in initiation and elongation during chromosome replication
LZG54_RS05450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LZG54_RS05455	COG0360	Binds together with S18 to 16S ribosomal RNA
LZG54_RS05465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LZG54_RS05470	COG1845	cytochrome c oxidase, subunit III
LZG54_RS05475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LZG54_RS05480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LZG54_RS05505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZG54_RS05520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LZG54_RS05525	COG2890	protein-(glutamine-N5) methyltransferase activity
LZG54_RS05530	COG3781	membrane
LZG54_RS05560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LZG54_RS05570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LZG54_RS05585	COG0477	Major facilitator Superfamily
LZG54_RS05590	COG0729	surface antigen
LZG54_RS05620	COG0308	aminopeptidase N
LZG54_RS05625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZG54_RS05635	COG0589	response to stress
LZG54_RS05640	COG0589	response to stress
LZG54_RS05660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LZG54_RS05675	COG0183	Belongs to the thiolase family
LZG54_RS05690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZG54_RS05695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LZG54_RS05700	COG1454	alcohol dehydrogenase
LZG54_RS05705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LZG54_RS05725	COG2197	response regulator
LZG54_RS05730	COG4585	Histidine kinase
LZG54_RS05735	COG2850	peptidyl-arginine hydroxylation
LZG54_RS05740	COG0424	maF-like protein
LZG54_RS05750	COG0126	phosphoglycerate kinase activity
LZG54_RS05785	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZG54_RS05795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LZG54_RS05825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LZG54_RS05830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LZG54_RS05835	COG2267	carboxylic ester hydrolase activity
LZG54_RS05845	COG1902	pentaerythritol trinitrate reductase activity
LZG54_RS05845	COG0446	pyridine nucleotide-disulphide oxidoreductase
LZG54_RS05875	COG0148	phosphopyruvate hydratase activity
LZG54_RS05880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LZG54_RS05890	COG0772	Belongs to the SEDS family
LZG54_RS05915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LZG54_RS05920	COG0730	response to heat
LZG54_RS05925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZG54_RS05965	COG4890	Cyd operon protein YbgT
LZG54_RS05970	COG1294	oxidase, subunit
LZG54_RS05990	COG1585	Membrane protein implicated in regulation of membrane protease activity
LZG54_RS06000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZG54_RS06020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LZG54_RS06025	COG0569	domain protein
LZG54_RS06030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LZG54_RS06035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LZG54_RS06055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LZG54_RS06060	COG0542	response to heat
LZG54_RS06090	COG0372	Belongs to the citrate synthase family
LZG54_RS06100	COG1058	Belongs to the CinA family
LZG54_RS06100	COG1546	Belongs to the CinA family
LZG54_RS06120	COG2814	Major facilitator Superfamily
LZG54_RS06130	COG2199	diguanylate cyclase activity
LZG54_RS06145	COG0668	transmembrane transport
LZG54_RS06150	COG3122	Protein conserved in bacteria
LZG54_RS06155	COG3619	membrane
LZG54_RS06175	COG2937	Belongs to the GPAT DAPAT family
LZG54_RS06180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LZG54_RS06190	COG0183	Belongs to the thiolase family
LZG54_RS06195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZG54_RS06200	COG0183	Belongs to the thiolase family
LZG54_RS06205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LZG54_RS06210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LZG54_RS06215	COG3135	benzoate transporter
LZG54_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
LZG54_RS06225	COG0543	2 iron, 2 sulfur cluster binding
LZG54_RS06225	COG0633	Ferredoxin
LZG54_RS06230	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LZG54_RS06235	COG4638	Rieske (2fe-2S)
LZG54_RS06245	COG4829	muconolactone delta-isomerase
LZG54_RS06250	COG4948	Mandelate Racemase Muconate Lactonizing
LZG54_RS06255	COG0583	DNA-binding transcription factor activity
LZG54_RS06260	COG2814	Major facilitator Superfamily
LZG54_RS06270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZG54_RS06315	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LZG54_RS06320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LZG54_RS06350	COG1960	acyl-CoA dehydrogenase activity
LZG54_RS06380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZG54_RS06400	COG2814	Major facilitator Superfamily
LZG54_RS06410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZG54_RS06435	COG2390	Transcriptional regulator
LZG54_RS06435	COG4584	PFAM Integrase catalytic
LZG54_RS06440	COG1484	DNA-dependent DNA replication
LZG54_RS06460	COG1132	(ABC) transporter
LZG54_RS06465	COG4628	conserved protein (DUF2132)
LZG54_RS06565	COG1201	RNA secondary structure unwinding
LZG54_RS06605	COG4372	Transposase
LZG54_RS06635	COG4372	Transposase
LZG54_RS06650	COG0604	alcohol dehydrogenase
LZG54_RS06655	COG1309	transcriptional regulator
LZG54_RS06660	COG4628	conserved protein (DUF2132)
LZG54_RS06675	COG1335	isochorismatase
LZG54_RS06680	COG1280	lysine exporter protein (LysE YggA)
LZG54_RS06695	COG1063	alcohol dehydrogenase
LZG54_RS06705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZG54_RS06710	COG0508	dehydrogenase complex catalyzes the overall conversion of
LZG54_RS06715	COG0022	dehydrogenase e1 component
LZG54_RS06720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LZG54_RS06725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LZG54_RS06745	COG0515	serine threonine protein kinase
LZG54_RS06750	COG2116	formate transmembrane transporter activity
LZG54_RS06755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LZG54_RS06775	COG2223	nitrite transmembrane transporter activity
LZG54_RS06780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LZG54_RS06785	COG4149	molybdate abc transporter
LZG54_RS06790	COG0725	ABC transporter, periplasmic molybdate-binding protein
LZG54_RS06795	COG0303	'Molybdopterin
LZG54_RS06800	COG0315	cyclic pyranopterin monophosphate synthase activity
LZG54_RS06800	COG0521	Mo-molybdopterin cofactor biosynthetic process
LZG54_RS06805	COG0314	molybdopterin synthase activity
LZG54_RS06815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LZG54_RS06825	COG0243	molybdopterin cofactor binding
LZG54_RS06830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LZG54_RS06835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LZG54_RS06845	COG1116	anion transmembrane transporter activity
LZG54_RS06845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LZG54_RS06880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZG54_RS06885	COG1944	ATP diphosphatase activity
LZG54_RS06895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LZG54_RS06900	COG0511	ligase activity, forming carbon-carbon bonds
LZG54_RS06910	COG0596	Alpha beta hydrolase
LZG54_RS06930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LZG54_RS06935	COG1283	sodium-dependent phosphate transmembrane transporter activity
LZG54_RS06985	COG0552	protein localization to endoplasmic reticulum
LZG54_RS06990	COG0612	Peptidase, M16
LZG54_RS07020	COG0517	IMP dehydrogenase activity
LZG54_RS07025	COG0133	tryptophan synthase activity
LZG54_RS07035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LZG54_RS07055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LZG54_RS07110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LZG54_RS07140	COG0822	iron-sulfur transferase activity
LZG54_RS07145	COG0316	Belongs to the HesB IscA family
LZG54_RS07175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LZG54_RS07190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LZG54_RS07195	COG0702	epimerase
LZG54_RS07200	COG0268	Binds directly to 16S ribosomal RNA
LZG54_RS07225	COG1011	Hydrolase
LZG54_RS07230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LZG54_RS07240	COG2137	regulation of response to DNA damage stimulus
LZG54_RS07255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZG54_RS07265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZG54_RS07275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZG54_RS07290	COG0575	Belongs to the CDS family
LZG54_RS07295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LZG54_RS07315	COG3852	Histidine kinase
LZG54_RS07330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZG54_RS07335	COG0583	DNA-binding transcription factor activity
LZG54_RS07340	COG0024	Methionine aminopeptidase
LZG54_RS07345	COG1114	Component of the transport system for branched-chain amino acids
LZG54_RS07365	COG1253	flavin adenine dinucleotide binding
LZG54_RS07380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LZG54_RS07385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LZG54_RS07400	COG2431	L-lysine efflux transmembrane transporter activity
LZG54_RS07445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LZG54_RS07465	COG2165	general secretion pathway protein
LZG54_RS07480	COG0084	hydrolase, TatD family'
LZG54_RS07500	COG1663	tetraacyldisaccharide 4'-kinase activity
LZG54_RS07505	COG1132	(ABC) transporter
LZG54_RS07515	COG0811	peptide transport
LZG54_RS07520	COG1475	DNA binding
LZG54_RS07525	COG1192	Involved in chromosome partitioning
LZG54_RS07535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LZG54_RS07550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LZG54_RS07585	COG4372	Transposase
LZG54_RS07595	COG1923	regulation of RNA biosynthetic process
LZG54_RS07605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LZG54_RS07610	COG0802	atpase or kinase
LZG54_RS07635	COG2707	UPF0756 membrane protein
LZG54_RS07640	COG0583	DNA-binding transcription factor activity
LZG54_RS07650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LZG54_RS07655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LZG54_RS07665	COG1454	alcohol dehydrogenase
LZG54_RS07685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LZG54_RS07685	COG0519	Catalyzes the synthesis of GMP from XMP
LZG54_RS07690	COG2353	YceI-like domain
LZG54_RS07700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LZG54_RS07705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LZG54_RS07745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LZG54_RS07745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LZG54_RS07760	COG3293	Transposase
LZG54_RS07780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LZG54_RS07820	COG1309	transcriptional regulator
LZG54_RS07840	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LZG54_RS07875	COG4221	oxidoreductase activity
LZG54_RS07895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LZG54_RS07900	COG1309	transcriptional regulator
LZG54_RS07905	COG1012	belongs to the aldehyde dehydrogenase family
LZG54_RS07915	COG0579	oxidoreductase
LZG54_RS07940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LZG54_RS07975	COG0642	Histidine kinase
LZG54_RS07990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LZG54_RS08030	COG2816	NAD+ diphosphatase activity
LZG54_RS08035	COG3046	protein related to deoxyribodipyrimidine photolyase
LZG54_RS08050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LZG54_RS08060	COG2826	transposase and inactivated derivatives, IS30 family
LZG54_RS08070	COG3706	GGDEF domain
LZG54_RS08075	COG0582	viral genome integration into host DNA
LZG54_RS08080	COG0582	viral genome integration into host DNA
LZG54_RS08105	COG1487	ribonuclease activity
LZG54_RS08125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZG54_RS08150	COG4584	PFAM Integrase catalytic
LZG54_RS08150	COG2390	Transcriptional regulator
LZG54_RS08155	COG1484	DNA-dependent DNA replication
LZG54_RS08170	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LZG54_RS08295	COG0443	Heat shock 70 kDa protein
LZG54_RS08300	COG1074	ATP-dependent DNA helicase activity
LZG54_RS08310	COG0582	viral genome integration into host DNA
LZG54_RS08350	COG1401	restriction endodeoxyribonuclease activity
LZG54_RS08385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZG54_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
LZG54_RS08430	COG2986	histidine ammonia-lyase
LZG54_RS08445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LZG54_RS08455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZG54_RS08460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZG54_RS08510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZG54_RS08535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LZG54_RS08665	COG0012	GTP binding
LZG54_RS08675	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LZG54_RS08685	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LZG54_RS08690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LZG54_RS08700	COG0386	Belongs to the glutathione peroxidase family
LZG54_RS08710	COG0436	Aminotransferase
LZG54_RS08740	COG0515	serine threonine protein kinase
LZG54_RS08740	COG2815	serine threonine protein kinase
LZG54_RS08770	COG1610	YqeY-like protein
LZG54_RS08810	COG1286	toxin biosynthetic process
LZG54_RS08815	COG0167	dihydroorotate dehydrogenase activity
LZG54_RS08840	COG0778	Nitroreductase
LZG54_RS08850	COG0513	Belongs to the DEAD box helicase family
LZG54_RS08855	COG1278	Cold shock
LZG54_RS08870	COG2363	Small membrane protein
LZG54_RS08890	COG0659	secondary active sulfate transmembrane transporter activity
LZG54_RS08895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LZG54_RS08920	COG2885	chlorophyll binding
LZG54_RS08920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LZG54_RS08930	COG0540	Belongs to the ATCase OTCase family
LZG54_RS08955	COG1765	OsmC-like protein
LZG54_RS08965	COG0667	Aldo Keto reductase
LZG54_RS08980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LZG54_RS08995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LZG54_RS09000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LZG54_RS09005	COG0527	aspartate kinase activity
LZG54_RS09015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LZG54_RS09025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LZG54_RS09030	COG2252	PERMEase
LZG54_RS09105	COG0582	viral genome integration into host DNA
LZG54_RS09125	COG0714	Associated with various cellular activities
LZG54_RS09130	COG2879	small protein
LZG54_RS09135	COG1966	Carbon starvation protein
LZG54_RS09140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LZG54_RS09145	COG1509	lysine 2,3-aminomutase activity
LZG54_RS09180	COG1067	ATP-dependent peptidase activity
LZG54_RS09185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LZG54_RS09190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZG54_RS09220	COG1686	Belongs to the peptidase S11 family
LZG54_RS09225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LZG54_RS09240	COG2915	High frequency lysogenization protein hflD homolog
LZG54_RS09260	COG0616	signal peptide processing
LZG54_RS09275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LZG54_RS09285	COG0573	inorganic phosphate transmembrane transporter activity
LZG54_RS09295	COG0076	glutamate decarboxylase activity
LZG54_RS09300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LZG54_RS09310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LZG54_RS09325	COG1733	regulation of RNA biosynthetic process
LZG54_RS09345	COG0556	nucleotide-excision repair
LZG54_RS09360	COG0436	Aminotransferase
LZG54_RS09385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LZG54_RS09400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LZG54_RS09405	COG0571	ribonuclease III activity
LZG54_RS09430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZG54_RS09440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LZG54_RS09455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LZG54_RS09465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LZG54_RS09480	COG4208	sulfate ABC transporter
LZG54_RS09485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LZG54_RS09490	COG0583	DNA-binding transcription factor activity
LZG54_RS09500	COG4625	pathogenesis
LZG54_RS09515	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LZG54_RS09525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LZG54_RS09530	COG1056	cytidyltransferase-related domain
LZG54_RS09530	COG1051	belongs to the nudix hydrolase family
LZG54_RS09535	COG1024	Enoyl-CoA hydratase
LZG54_RS09560	COG2255	four-way junction helicase activity
LZG54_RS09570	COG0824	Thioesterase
LZG54_RS09590	COG0823	Involved in the tonB-independent uptake of proteins
LZG54_RS09610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LZG54_RS09640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LZG54_RS09645	COG0628	permease
LZG54_RS09650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LZG54_RS09655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LZG54_RS09675	COG0658	competence protein
LZG54_RS09675	COG2333	competence protein COMEC
LZG54_RS09685	COG1136	(ABC) transporter
LZG54_RS09690	COG4591	ABC-type transport system involved in lipoprotein release permease component
LZG54_RS09715	COG1671	Belongs to the UPF0178 family
LZG54_RS09760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LZG54_RS09775	COG0019	diaminopimelate decarboxylase activity
LZG54_RS09785	COG1113	amino acid transport
LZG54_RS09790	COG1115	amino acid carrier protein
LZG54_RS09805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZG54_RS09810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LZG54_RS09815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LZG54_RS09850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LZG54_RS09860	COG0174	glutamine synthetase
LZG54_RS09865	COG0512	Glutamine amidotransferase of anthranilate synthase
LZG54_RS09870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LZG54_RS09885	COG0302	gtp cyclohydrolase
LZG54_RS09890	COG3706	GGDEF domain
LZG54_RS09905	COG3739	integral membrane protein
LZG54_RS09920	COG1741	Belongs to the pirin family
LZG54_RS09925	COG2072	flavoprotein involved in K transport
LZG54_RS09970	COG0175	sulfate reduction
LZG54_RS09990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LZG54_RS09995	COG1773	rubredoxin
LZG54_RS10000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LZG54_RS10010	COG0583	DNA-binding transcription factor activity
LZG54_RS10025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LZG54_RS10030	COG0705	Rhomboid family
LZG54_RS10030	COG0457	Tetratricopeptide repeat
LZG54_RS10035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LZG54_RS10040	COG4181	ATPase activity
LZG54_RS10090	COG0306	phosphate transporter
LZG54_RS10110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZG54_RS10130	COG1196	nuclear chromosome segregation
LZG54_RS10130	COG0741	lytic transglycosylase activity
LZG54_RS10130	COG0739	heme binding
LZG54_RS10135	COG0501	Belongs to the peptidase M48B family
LZG54_RS10145	COG2239	Acts as a magnesium transporter
LZG54_RS10170	COG0582	viral genome integration into host DNA
LZG54_RS10340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LZG54_RS10355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZG54_RS10395	COG0459	protein refolding
LZG54_RS10410	COG1597	lipid kinase activity
LZG54_RS10430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LZG54_RS10470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LZG54_RS10475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LZG54_RS10500	COG0505	Belongs to the CarA family
LZG54_RS10525	COG0589	response to stress
LZG54_RS10530	COG3695	enzyme binding
LZG54_RS10535	COG2321	neutral zinc metallopeptidase
LZG54_RS10540	COG2354	Protein conserved in bacteria
LZG54_RS10550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LZG54_RS10560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZG54_RS10575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LZG54_RS10580	COG1053	succinate dehydrogenase
LZG54_RS10585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LZG54_RS10605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZG54_RS10605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LZG54_RS10625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LZG54_RS10650	COG0564	pseudouridine synthase activity
LZG54_RS10660	COG0358	DNA primase activity
LZG54_RS10665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LZG54_RS10675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LZG54_RS10705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LZG54_RS10730	COG1054	Belongs to the UPF0176 family
LZG54_RS10740	COG0586	Pfam SNARE associated Golgi protein
LZG54_RS10775	COG0321	lipoyl(octanoyl) transferase activity
LZG54_RS10790	COG0531	amino acid
LZG54_RS10800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LZG54_RS10805	COG1648	precorrin-2 dehydrogenase activity
LZG54_RS10805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LZG54_RS10810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LZG54_RS10820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LZG54_RS10845	COG0671	phosphoesterase, PA-phosphatase related
LZG54_RS10850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZG54_RS10860	COG1538	Outer membrane efflux protein
LZG54_RS10865	COG0393	Putative heavy-metal-binding
LZG54_RS10870	COG0393	Putative heavy-metal-binding
LZG54_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
LZG54_RS10885	COG0525	valine-tRNA ligase activity
LZG54_RS10900	COG2323	membrane
LZG54_RS10915	COG1752	Esterase of the alpha-beta hydrolase superfamily
LZG54_RS10930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZG54_RS10935	COG2205	protein histidine kinase activity
LZG54_RS10940	COG0745	RESPONSE REGULATOR receiver
LZG54_RS10950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LZG54_RS10960	COG1652	LysM domain
LZG54_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
LZG54_RS10985	COG1399	metal-binding, possibly nucleic acid-binding protein
LZG54_RS10990	COG3101	peptidyl-lysine hydroxylation
LZG54_RS10995	COG0009	L-threonylcarbamoyladenylate synthase
LZG54_RS11000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LZG54_RS11005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LZG54_RS11020	COG4106	trans-aconitate 2-methyltransferase activity
LZG54_RS11035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZG54_RS11035	COG2226	methyltransferase
LZG54_RS11035	COG0596	Alpha beta hydrolase
LZG54_RS11040	COG2193	ferroxidase activity
LZG54_RS11045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZG54_RS11050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LZG54_RS11055	COG3115	cell septum assembly
LZG54_RS11060	COG1196	nuclear chromosome segregation
LZG54_RS11070	COG0730	response to heat
LZG54_RS11085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LZG54_RS11095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LZG54_RS11110	COG3422	double-strand break repair
LZG54_RS11115	COG2824	Alkylphosphonate utilization operon protein PhnA
LZG54_RS11120	COG3189	MarR family transcriptional regulator
LZG54_RS11135	COG0564	pseudouridine synthase activity
LZG54_RS11160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LZG54_RS11165	COG0354	folic acid binding
LZG54_RS11180	COG1902	pentaerythritol trinitrate reductase activity
LZG54_RS11190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LZG54_RS11195	COG1970	mechanosensitive ion channel activity
LZG54_RS11200	COG1217	gtp-binding protein TYPA
LZG54_RS11205	COG2233	PERMEase
LZG54_RS11215	COG0833	amino acid
LZG54_RS11230	COG0183	Belongs to the thiolase family
LZG54_RS11245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LZG54_RS11250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LZG54_RS11255	COG2207	Transcriptional regulator
LZG54_RS11260	COG0183	Belongs to the thiolase family
LZG54_RS11265	COG1024	Enoyl-CoA hydratase
LZG54_RS11265	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZG54_RS11285	COG1272	protein, Hemolysin III
LZG54_RS11290	COG0477	Major facilitator Superfamily
LZG54_RS11295	COG1408	metallophosphoesterase
LZG54_RS11300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZG54_RS11310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LZG54_RS11340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LZG54_RS11345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LZG54_RS11360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LZG54_RS11365	COG0625	glutathione transferase activity
LZG54_RS11370	COG2969	positive regulation of protein catabolic process
LZG54_RS11410	COG1183	phosphatidylcholine synthase activity
LZG54_RS11415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LZG54_RS11445	COG3293	Transposase
LZG54_RS11465	COG0251	oxidation-reduction process
LZG54_RS11485	COG4372	Transposase
LZG54_RS11505	COG0741	lytic transglycosylase activity
LZG54_RS11505	COG0739	heme binding
LZG54_RS11505	COG1196	nuclear chromosome segregation
LZG54_RS11510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LZG54_RS11515	COG1702	phosphate starvation-inducible protein PhoH
LZG54_RS11520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LZG54_RS11560	COG1295	ribonuclease BN
LZG54_RS11585	COG0788	formyltetrahydrofolate deformylase activity
LZG54_RS11610	COG4651	solute:proton antiporter activity
LZG54_RS11610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LZG54_RS11625	COG0724	RNA recognition motif
LZG54_RS11655	COG2900	Belongs to the SlyX family
LZG54_RS11660	COG0488	(ABC) transporter
LZG54_RS11665	COG1560	Kdo2-lipid A biosynthetic process
LZG54_RS11695	COG0252	asparaginase activity
LZG54_RS11700	COG0101	tRNA pseudouridine synthase activity
LZG54_RS11720	COG0473	3-isopropylmalate dehydrogenase activity
LZG54_RS11735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LZG54_RS11745	COG0583	DNA-binding transcription factor activity
LZG54_RS11775	COG0753	catalase activity
LZG54_RS11790	COG0583	DNA-binding transcription factor activity
LZG54_RS11800	COG0546	phosphoglycolate phosphatase activity
LZG54_RS11810	COG1530	ribonuclease E activity
LZG54_RS11815	COG0318	PFAM AMP-dependent synthetase and ligase
LZG54_RS11840	COG1983	PspC domain protein
LZG54_RS11845	COG0517	IMP dehydrogenase activity
LZG54_RS11845	COG0617	tRNA 3'-terminal CCA addition
LZG54_RS11845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LZG54_RS11855	COG0751	glycine-tRNA ligase activity
LZG54_RS11885	COG2226	methyltransferase
LZG54_RS11895	COG0493	'glutamate synthase
LZG54_RS11905	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LZG54_RS11910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZG54_RS11925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LZG54_RS11935	COG0644	oxidoreductase
LZG54_RS11935	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LZG54_RS11950	COG4535	Mg2 and Co2 transporter CorC
LZG54_RS11955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LZG54_RS11970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LZG54_RS11980	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LZG54_RS12020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LZG54_RS12025	COG1074	ATP-dependent DNA helicase activity
LZG54_RS12030	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LZG54_RS12050	COG2226	methyltransferase
LZG54_RS12060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZG54_RS12085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LZG54_RS12085	COG2111	Na H antiporter
LZG54_RS12090	COG1006	Multisubunit Na H antiporter MnhC subunit
LZG54_RS12095	COG0651	ATP synthesis coupled electron transport
LZG54_RS12100	COG1863	multisubunit Na H antiporter MnhE subunit
LZG54_RS12105	COG2212	antiporter activity
LZG54_RS12110	COG1320	monovalent cation:proton antiporter activity
LZG54_RS12115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LZG54_RS12120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LZG54_RS12125	COG0195	Participates in both transcription termination and antitermination
LZG54_RS12130	COG0779	Required for maturation of 30S ribosomal subunits
LZG54_RS12185	COG0237	dephospho-CoA kinase activity
LZG54_RS12195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LZG54_RS12200	COG3123	guanosine phosphorylase activity
LZG54_RS12205	COG0497	DNA recombination
LZG54_RS12235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LZG54_RS12255	COG1132	(ABC) transporter
LZG54_RS12260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LZG54_RS12270	COG0322	excinuclease ABC activity
LZG54_RS12290	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZG54_RS12290	COG1024	Enoyl-CoA hydratase
LZG54_RS12310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LZG54_RS12340	COG0326	Molecular chaperone. Has ATPase activity
LZG54_RS12350	COG3047	cAMP biosynthetic process
LZG54_RS12355	COG2056	Na+-H+ antiporter family
LZG54_RS12390	COG0085	RNA polymerase activity
LZG54_RS12405	COG0081	regulation of translation
LZG54_RS12490	COG0824	Thioesterase
LZG54_RS12510	COG0181	hydroxymethylbilane synthase activity
LZG54_RS12520	COG3275	phosphorelay sensor kinase activity
LZG54_RS12525	COG0165	Argininosuccinate lyase
LZG54_RS12540	COG1538	Outer membrane efflux protein
LZG54_RS12560	COG0494	nUDIX hydrolase
LZG54_RS12565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LZG54_RS12570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LZG54_RS12575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LZG54_RS12585	COG0772	Belongs to the SEDS family
LZG54_RS12610	COG4974	Belongs to the 'phage' integrase family
LZG54_RS12615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LZG54_RS12625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LZG54_RS12635	COG2197	response regulator
LZG54_RS12650	COG0793	Belongs to the peptidase S41A family
LZG54_RS12655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LZG54_RS12660	COG0795	lipopolysaccharide-transporting ATPase activity
LZG54_RS12665	COG0795	lipopolysaccharide-transporting ATPase activity
LZG54_RS12690	COG0586	Pfam SNARE associated Golgi protein
LZG54_RS12705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LZG54_RS12705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LZG54_RS12715	COG0004	ammonium transporteR
LZG54_RS12720	COG0347	Belongs to the P(II) protein family
LZG54_RS12730	COG0606	chelatase, subunit chli
LZG54_RS12745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LZG54_RS12760	COG0318	PFAM AMP-dependent synthetase and ligase
LZG54_RS12775	COG0477	Major facilitator Superfamily
LZG54_RS12780	COG2860	membrane
LZG54_RS12790	COG1253	flavin adenine dinucleotide binding
LZG54_RS12825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZG54_RS12845	COG2814	Major facilitator Superfamily
LZG54_RS12850	COG2814	Major facilitator Superfamily
LZG54_RS12900	COG0758	DNA mediated transformation
LZG54_RS12910	COG0697	spore germination
LZG54_RS12915	COG0386	Belongs to the glutathione peroxidase family
LZG54_RS12930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LZG54_RS12980	COG1121	(ABC) transporter
LZG54_RS12985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LZG54_RS13000	COG2837	iron assimilation
LZG54_RS13090	COG2132	Multicopper oxidase
LZG54_RS13105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LZG54_RS13135	COG2826	transposase and inactivated derivatives, IS30 family
LZG54_RS13155	COG2217	Heavy metal translocating P-type atpase
LZG54_RS13160	COG3174	membrane
LZG54_RS13165	COG2205	protein histidine kinase activity
LZG54_RS13195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZG54_RS13200	COG2026	Addiction module toxin, RelE StbE family
LZG54_RS13240	COG4372	Transposase
LZG54_RS13285	COG4372	Transposase
LZG54_RS13295	COG2963	transposase activity
LZG54_RS13335	COG3077	Addiction module antitoxin, RelB DinJ family
LZG54_RS13370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LZG54_RS13375	COG0659	secondary active sulfate transmembrane transporter activity
LZG54_RS13385	COG3077	Addiction module antitoxin, RelB DinJ family
LZG54_RS13445	COG2814	Major facilitator Superfamily
LZG54_RS13455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LZG54_RS13455	COG0351	phosphomethylpyrimidine kinase
LZG54_RS13455	COG0352	thiamine-phosphate diphosphorylase activity
LZG54_RS13480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZG54_RS13485	COG3162	membrane
LZG54_RS13490	COG0784	Response regulator, receiver
LZG54_RS13490	COG2205	protein histidine kinase activity
LZG54_RS13500	COG0281	malic enzyme
LZG54_RS13535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LZG54_RS13535	COG0519	Catalyzes the synthesis of GMP from XMP
LZG54_RS13540	COG0586	Pfam SNARE associated Golgi protein
LZG54_RS13555	COG1192	Involved in chromosome partitioning
LZG54_RS13560	COG3094	Invasion gene expression up-regulator, SirB
LZG54_RS13565	COG0271	Belongs to the BolA IbaG family
LZG54_RS13580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LZG54_RS13595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LZG54_RS13610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LZG54_RS13620	COG1216	Glycosyl transferase, family 2
LZG54_RS13650	COG2244	polysaccharide biosynthetic process
LZG54_RS13665	COG1091	dTDP-4-dehydrorhamnose reductase activity
LZG54_RS13675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LZG54_RS13680	COG1596	polysaccharide export
LZG54_RS13705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LZG54_RS13735	COG1309	transcriptional regulator
LZG54_RS13745	COG2233	PERMEase
LZG54_RS13765	COG0129	dihydroxy-acid dehydratase activity
LZG54_RS13780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LZG54_RS13790	COG0733	neurotransmitter:sodium symporter activity
LZG54_RS13795	COG1012	belongs to the aldehyde dehydrogenase family
LZG54_RS13830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LZG54_RS13840	COG0657	acetylesterase activity
LZG54_RS13850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LZG54_RS13870	COG2951	lytic endotransglycosylase activity
LZG54_RS13875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LZG54_RS13890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LZG54_RS13900	COG2200	EAL domain
LZG54_RS13910	COG0861	Integral membrane protein TerC family
LZG54_RS13915	COG0402	S-adenosylhomocysteine deaminase activity
LZG54_RS13965	COG0706	membrane insertase activity
LZG54_RS13970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LZG54_RS13975	COG0594	ribonuclease P activity
LZG54_RS14130	COG3586	endonuclease activity
LZG54_RS14205	COG2826	transposase and inactivated derivatives, IS30 family
LZG54_RS14265	COG1660	Displays ATPase and GTPase activities
LZG54_RS14300	COG3173	Aminoglycoside phosphotransferase
LZG54_RS14305	COG0488	(ABC) transporter
LZG54_RS14315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZG54_RS14335	COG1475	DNA binding
LZG54_RS14340	COG1192	Involved in chromosome partitioning
LZG54_RS14345	COG1570	exodeoxyribonuclease VII activity
LZG54_RS14360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LZG54_RS14395	COG1192	Involved in chromosome partitioning
LZG54_RS14400	COG1475	DNA binding
LZG54_RS14430	COG2184	nucleotidyltransferase activity
LZG54_RS14520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LZG54_RS14540	COG3335	DDE superfamily endonuclease
LZG54_RS14555	COG1840	ABC-type Fe3 transport system, periplasmic component
LZG54_RS14565	COG0159	tryptophan synthase activity
LZG54_RS14575	COG1846	Transcriptional regulator
LZG54_RS14630	COG3077	Addiction module antitoxin, RelB DinJ family