locus-tag	class	description
I6I52_RS00020	COG0519	Catalyzes the synthesis of GMP from XMP
I6I52_RS00020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I52_RS00025	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I52_RS00030	COG2259	Doxx family
I6I52_RS00035	COG0586	Pfam SNARE associated Golgi protein
I6I52_RS00050	COG1192	Involved in chromosome partitioning
I6I52_RS00095	COG3756	Protein conserved in bacteria
I6I52_RS00110	COG3293	Transposase
I6I52_RS00125	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I52_RS00130	COG0842	Transport permease protein
I6I52_RS00135	COG0842	Transport permease protein
I6I52_RS00135	COG1129	ABC transporter
I6I52_RS00140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I52_RS00190	COG3550	peptidyl-serine autophosphorylation
I6I52_RS00195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I52_RS00205	COG4716	Myosin-crossreactive antigen
I6I52_RS00230	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I52_RS00235	COG1733	regulation of RNA biosynthetic process
I6I52_RS00250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I52_RS00265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I52_RS00270	COG3162	membrane
I6I52_RS00275	COG2205	protein histidine kinase activity
I6I52_RS00275	COG0784	Response regulator, receiver
I6I52_RS00290	COG0004	ammonium transporteR
I6I52_RS00320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I52_RS00330	COG0668	transmembrane transport
I6I52_RS00340	COG1519	Transferase
I6I52_RS00350	COG1902	pentaerythritol trinitrate reductase activity
I6I52_RS00375	COG1476	TRANSCRIPTIONal
I6I52_RS00380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I52_RS00385	COG0259	pyridoxamine-phosphate oxidase activity
I6I52_RS00405	COG0426	domain, Protein
I6I52_RS00405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I52_RS00410	COG2119	membrane
I6I52_RS00445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I52_RS00455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I52_RS00460	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I52_RS00470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I52_RS00475	COG0189	ligase activity
I6I52_RS00495	COG0708	Exodeoxyribonuclease III
I6I52_RS00500	COG1393	Belongs to the ArsC family
I6I52_RS00515	COG3706	GGDEF domain
I6I52_RS00520	COG0625	glutathione transferase activity
I6I52_RS00565	COG1247	-acetyltransferase
I6I52_RS00575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I52_RS00580	COG4266	Belongs to the allantoicase family
I6I52_RS00585	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6I52_RS00605	COG3150	esterase
I6I52_RS00615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I52_RS00620	COG2918	glutathione biosynthetic process
I6I52_RS00635	COG2733	membrane
I6I52_RS00640	COG0436	Aminotransferase
I6I52_RS00645	COG0534	Mate efflux family protein
I6I52_RS00675	COG0300	oxidoreductase activity
I6I52_RS00685	COG0688	phosphatidylethanolamine metabolic process
I6I52_RS00695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I52_RS00715	COG0560	Phosphoserine phosphatase
I6I52_RS00715	COG3830	Belongs to the UPF0237 family
I6I52_RS00730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I52_RS00735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I52_RS00740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I52_RS00745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I52_RS00755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I52_RS00770	COG3121	Chaperone
I6I52_RS00780	COG3188	usher protein
I6I52_RS00800	COG2388	GCN5-related N-acetyl-transferase
I6I52_RS00805	COG0385	Bile acid
I6I52_RS00810	COG1335	isochorismatase
I6I52_RS00815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I52_RS00825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I52_RS00830	COG2116	formate transmembrane transporter activity
I6I52_RS00835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I52_RS00845	COG2133	pyrroloquinoline quinone binding
I6I52_RS00860	COG2983	Belongs to the UPF0260 family
I6I52_RS00865	COG5487	UPF0391 membrane protein
I6I52_RS00870	COG0412	Dienelactone hydrolase
I6I52_RS00880	COG1194	a g-specific adenine glycosylase
I6I52_RS00895	COG2818	Glycosylase
I6I52_RS00900	COG1064	alcohol dehydrogenase
I6I52_RS00905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I52_RS00915	COG0583	DNA-binding transcription factor activity
I6I52_RS00920	COG2814	Major facilitator Superfamily
I6I52_RS00930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I52_RS00935	COG0484	heat shock protein binding
I6I52_RS00950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I52_RS00955	COG1309	transcriptional regulator
I6I52_RS00960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I52_RS00965	COG2233	PERMEase
I6I52_RS00980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I52_RS00985	COG1252	NADH dehydrogenase
I6I52_RS01000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I52_RS01005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I52_RS01010	COG0428	transporter
I6I52_RS01020	COG0733	neurotransmitter:sodium symporter activity
I6I52_RS01025	COG1012	belongs to the aldehyde dehydrogenase family
I6I52_RS01040	COG0693	protein deglycase activity
I6I52_RS01075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I52_RS01080	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I52_RS01085	COG0316	Belongs to the HesB IscA family
I6I52_RS01105	COG0488	(ABC) transporter
I6I52_RS01115	COG0187	DNA topoisomerase II activity
I6I52_RS01120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I52_RS01125	COG0592	DNA-directed DNA polymerase activity
I6I52_RS01135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I52_RS01145	COG0594	ribonuclease P activity
I6I52_RS01150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I52_RS01155	COG0706	membrane insertase activity
I6I52_RS01165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I52_RS01180	COG0402	S-adenosylhomocysteine deaminase activity
I6I52_RS01190	COG0861	Integral membrane protein TerC family
I6I52_RS01215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I52_RS01230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I52_RS01235	COG2951	lytic endotransglycosylase activity
I6I52_RS01250	COG0443	Heat shock 70 kDa protein
I6I52_RS01255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I52_RS01260	COG0583	DNA-binding transcription factor activity
I6I52_RS01280	COG0657	acetylesterase activity
I6I52_RS01285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I52_RS01315	COG3676	manually curated
I6I52_RS01385	COG1047	Peptidyl-prolyl cis-trans
I6I52_RS01390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I52_RS01395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I52_RS01400	COG0196	riboflavin kinase activity
I6I52_RS01415	COG0596	Alpha beta hydrolase
I6I52_RS01420	COG1309	transcriptional regulator
I6I52_RS01425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I52_RS01430	COG1335	isochorismatase
I6I52_RS01435	COG0251	oxidation-reduction process
I6I52_RS01440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I52_RS01445	COG2233	PERMEase
I6I52_RS01455	COG1116	anion transmembrane transporter activity
I6I52_RS01460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I52_RS01465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I52_RS01470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I52_RS01475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I52_RS01480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I52_RS01480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I52_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS01505	COG0546	phosphoglycolate phosphatase activity
I6I52_RS01510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I52_RS01540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I52_RS01560	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I52_RS01590	COG1596	polysaccharide export
I6I52_RS01595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I52_RS01600	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I52_RS01605	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I52_RS01675	COG0438	transferase activity, transferring glycosyl groups
I6I52_RS01680	COG0297	glycogen (starch) synthase activity
I6I52_RS01700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I52_RS01715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I52_RS01725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I52_RS01730	COG0583	DNA-binding transcription factor activity
I6I52_RS01735	COG1620	l-lactate permease
I6I52_RS01740	COG2186	Transcriptional regulator
I6I52_RS01745	COG1304	FMN binding
I6I52_RS01750	COG0277	FAD linked oxidase domain protein
I6I52_RS01770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I52_RS01780	COG0251	oxidation-reduction process
I6I52_RS01790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I52_RS01805	COG1538	Outer membrane efflux protein
I6I52_RS01840	COG1335	isochorismatase
I6I52_RS01870	COG3706	GGDEF domain
I6I52_RS01905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I52_RS01915	COG2814	Major facilitator Superfamily
I6I52_RS01930	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I52_RS01940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I52_RS02000	COG4372	Transposase
I6I52_RS02015	COG3177	Filamentation induced by cAMP protein fic
I6I52_RS02110	COG0582	viral genome integration into host DNA
I6I52_RS02120	COG3158	transport of potassium into the cell
I6I52_RS02160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I52_RS02180	COG0531	amino acid
I6I52_RS02185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I52_RS02190	COG1132	(ABC) transporter
I6I52_RS02200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I52_RS02210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I52_RS02215	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I52_RS02245	COG0456	acetyltransferase
I6I52_RS02250	COG0427	acetyl-CoA hydrolase
I6I52_RS02280	COG4221	oxidoreductase activity
I6I52_RS02290	COG0028	Belongs to the TPP enzyme family
I6I52_RS02295	COG0488	(ABC) transporter
I6I52_RS02345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I52_RS02360	COG0275	rRNA processing
I6I52_RS02375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I52_RS02380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I52_RS02385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I52_RS02390	COG2226	methyltransferase
I6I52_RS02425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I52_RS02430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I52_RS02440	COG0070	glutamate synthase
I6I52_RS02440	COG0067	glutamate synthase
I6I52_RS02440	COG0069	glutamate synthase activity
I6I52_RS02445	COG0493	'glutamate synthase
I6I52_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS02465	COG1704	LemA family
I6I52_RS02470	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I52_RS02485	COG3307	-O-antigen
I6I52_RS02495	COG3307	-O-antigen
I6I52_RS02515	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I52_RS02515	COG1024	Enoyl-CoA hydratase
I6I52_RS02530	COG0322	excinuclease ABC activity
I6I52_RS02540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I52_RS02555	COG1132	(ABC) transporter
I6I52_RS02565	COG1289	transmembrane transporter activity
I6I52_RS02580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I52_RS02585	COG1678	Uncharacterized ACR, COG1678
I6I52_RS02590	COG0497	DNA recombination
I6I52_RS02595	COG3123	guanosine phosphorylase activity
I6I52_RS02600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I52_RS02610	COG0237	dephospho-CoA kinase activity
I6I52_RS02630	COG0149	triose-phosphate isomerase activity
I6I52_RS02655	COG0779	Required for maturation of 30S ribosomal subunits
I6I52_RS02660	COG0195	Participates in both transcription termination and antitermination
I6I52_RS02675	COG1320	monovalent cation:proton antiporter activity
I6I52_RS02680	COG2212	antiporter activity
I6I52_RS02685	COG1863	multisubunit Na H antiporter MnhE subunit
I6I52_RS02690	COG0651	ATP synthesis coupled electron transport
I6I52_RS02695	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I52_RS02700	COG2111	Na H antiporter
I6I52_RS02700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I52_RS02725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I52_RS02735	COG2226	methyltransferase
I6I52_RS02760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I52_RS02765	COG1074	ATP-dependent DNA helicase activity
I6I52_RS02770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I52_RS02775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I52_RS02780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I52_RS02785	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I52_RS02790	COG2841	Protein conserved in bacteria
I6I52_RS02795	COG0598	Magnesium transport protein CorA
I6I52_RS02800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I52_RS02815	COG0484	heat shock protein binding
I6I52_RS02820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I52_RS02830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I52_RS02850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I52_RS02855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I52_RS02860	COG4535	Mg2 and Co2 transporter CorC
I6I52_RS02865	COG0425	Belongs to the sulfur carrier protein TusA family
I6I52_RS02880	COG0644	oxidoreductase
I6I52_RS02880	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I52_RS02890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I52_RS02900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I52_RS02905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I52_RS02915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I52_RS02925	COG0493	'glutamate synthase
I6I52_RS02925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I52_RS02945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I52_RS02960	COG0254	rRNA binding
I6I52_RS02965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I52_RS02980	COG0534	Mate efflux family protein
I6I52_RS02990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I52_RS03000	COG1595	DNA-templated transcription, initiation
I6I52_RS03010	COG4221	oxidoreductase activity
I6I52_RS03015	COG0583	DNA-binding transcription factor activity
I6I52_RS03020	COG0450	alkyl hydroperoxide reductase
I6I52_RS03035	COG0318	PFAM AMP-dependent synthetase and ligase
I6I52_RS03040	COG1530	ribonuclease E activity
I6I52_RS03045	COG0564	pseudouridine synthase activity
I6I52_RS03060	COG0583	DNA-binding transcription factor activity
I6I52_RS03075	COG4993	Dehydrogenase
I6I52_RS03080	COG0753	catalase activity
I6I52_RS03090	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS03100	COG0494	nUDIX hydrolase
I6I52_RS03115	COG0583	DNA-binding transcription factor activity
I6I52_RS03130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I52_RS03145	COG0473	3-isopropylmalate dehydrogenase activity
I6I52_RS03155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I52_RS03165	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS03170	COG0101	tRNA pseudouridine synthase activity
I6I52_RS03205	COG1301	dicarboxylic acid transport
I6I52_RS03210	COG0438	transferase activity, transferring glycosyl groups
I6I52_RS03215	COG1560	Kdo2-lipid A biosynthetic process
I6I52_RS03225	COG0488	(ABC) transporter
I6I52_RS03230	COG2900	Belongs to the SlyX family
I6I52_RS03260	COG4251	negative regulation of phosphorylation
I6I52_RS03260	COG2203	Gaf domain
I6I52_RS03260	COG3706	GGDEF domain
I6I52_RS03260	COG5001	Diguanylate cyclase
I6I52_RS03270	COG0210	DNA helicase
I6I52_RS03290	COG4651	solute:proton antiporter activity
I6I52_RS03290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I52_RS03315	COG0788	formyltetrahydrofolate deformylase activity
I6I52_RS03355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I52_RS03370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I52_RS03405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I52_RS03415	COG2813	Specifically methylates the guanine in position
I6I52_RS03415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I52_RS03420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I52_RS03425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I52_RS03430	COG3128	pkhd-type hydroxylase
I6I52_RS03435	COG4774	siderophore transport
I6I52_RS03440	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I52_RS03445	COG0740	serine-type endopeptidase activity
I6I52_RS03470	COG3622	Belongs to the hyi family
I6I52_RS03485	COG0784	Response regulator, receiver
I6I52_RS03485	COG2205	protein histidine kinase activity
I6I52_RS03485	COG5002	protein histidine kinase activity
I6I52_RS03505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I52_RS03525	COG2096	Adenosyltransferase
I6I52_RS03530	COG4206	TonB-dependent receptor
I6I52_RS03570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I52_RS03575	COG0285	dihydrofolate synthase activity
I6I52_RS03595	COG0450	alkyl hydroperoxide reductase
I6I52_RS03600	COG0653	protein targeting
I6I52_RS03610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I52_RS03615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I52_RS03640	COG2885	chlorophyll binding
I6I52_RS03645	COG2199	diguanylate cyclase activity
I6I52_RS03715	COG1607	acyl-coa hydrolase
I6I52_RS03720	COG1956	GAF domain-containing protein
I6I52_RS03750	COG0183	Belongs to the thiolase family
I6I52_RS03765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I52_RS03770	COG5510	response to toxic substance
I6I52_RS03780	COG2832	Protein of unknown function (DUF454)
I6I52_RS03785	COG1376	ErfK ybiS ycfS ynhG family protein
I6I52_RS03830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I52_RS03840	COG1289	transmembrane transporter activity
I6I52_RS03845	COG2814	Major facilitator Superfamily
I6I52_RS03860	COG0786	glutamate:sodium symporter activity
I6I52_RS03865	COG1115	amino acid carrier protein
I6I52_RS03870	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I52_RS03885	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I52_RS03890	COG0494	nUDIX hydrolase
I6I52_RS03895	COG3422	double-strand break repair
I6I52_RS03910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I52_RS03920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I52_RS03925	COG3545	Serine hydrolase
I6I52_RS03935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I52_RS03935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I52_RS03940	COG0730	response to heat
I6I52_RS03950	COG1196	nuclear chromosome segregation
I6I52_RS03960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I52_RS03975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I52_RS03990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I52_RS03990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I52_RS04000	COG4106	trans-aconitate 2-methyltransferase activity
I6I52_RS04020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I52_RS04025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I52_RS04035	COG0009	L-threonylcarbamoyladenylate synthase
I6I52_RS04040	COG3101	peptidyl-lysine hydroxylation
I6I52_RS04045	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I52_RS04070	COG1652	LysM domain
I6I52_RS04080	COG1733	regulation of RNA biosynthetic process
I6I52_RS04085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I52_RS04085	COG0351	phosphomethylpyrimidine kinase
I6I52_RS04085	COG0352	thiamine-phosphate diphosphorylase activity
I6I52_RS04105	COG1981	membrane
I6I52_RS04130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I52_RS04135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I52_RS04145	COG0456	acetyltransferase
I6I52_RS04150	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I52_RS04155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I52_RS04160	COG0500	methyltransferase
I6I52_RS04165	COG0492	ferredoxin-NADP+ reductase activity
I6I52_RS04170	COG0531	amino acid
I6I52_RS04170	COG1674	ftsk spoiiie
I6I52_RS04180	COG1280	lysine exporter protein (LysE YggA)
I6I52_RS04190	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I52_RS04195	COG2894	cell division
I6I52_RS04200	COG0850	regulation of cytokinetic process
I6I52_RS04210	COG0204	Acyl-transferase
I6I52_RS04215	COG2885	chlorophyll binding
I6I52_RS04225	COG0756	dUTP diphosphatase activity
I6I52_RS04230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I52_RS04235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I52_RS04245	COG0121	glutamine amidotransferase
I6I52_RS04260	COG2914	Belongs to the UPF0125 (RnfH) family
I6I52_RS04265	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I52_RS04270	COG0735	belongs to the Fur family
I6I52_RS04290	COG1968	undecaprenyl-diphosphatase activity
I6I52_RS04310	COG0420	3'-5' exonuclease activity
I6I52_RS04335	COG2050	protein possibly involved in aromatic compounds catabolism
I6I52_RS04340	COG1566	PFAM secretion protein HlyD family protein
I6I52_RS04345	COG2814	Major facilitator Superfamily
I6I52_RS04350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I52_RS04390	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I52_RS04395	COG2223	nitrite transmembrane transporter activity
I6I52_RS04405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I52_RS04410	COG1301	dicarboxylic acid transport
I6I52_RS04415	COG0436	Aminotransferase
I6I52_RS04420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I52_RS04425	COG0583	DNA-binding transcription factor activity
I6I52_RS04455	COG2223	nitrite transmembrane transporter activity
I6I52_RS04470	COG0577	efflux transmembrane transporter activity
I6I52_RS04470	COG1136	(ABC) transporter
I6I52_RS04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I52_RS04500	COG0028	Belongs to the TPP enzyme family
I6I52_RS04510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I52_RS04525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I52_RS04540	COG0084	hydrolase, TatD family'
I6I52_RS04550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I52_RS04560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I52_RS04570	COG0582	viral genome integration into host DNA
I6I52_RS04590	COG3617	BRO family, N-terminal domain
I6I52_RS04635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I52_RS04655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I52_RS04675	COG1414	Transcriptional regulator
I6I52_RS04695	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS04705	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I52_RS04710	COG2271	Major facilitator Superfamily
I6I52_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS04730	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I52_RS04735	COG1012	belongs to the aldehyde dehydrogenase family
I6I52_RS04740	COG0028	Belongs to the TPP enzyme family
I6I52_RS04755	COG1120	ATPase activity
I6I52_RS04760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I52_RS04785	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I52_RS04790	COG1012	belongs to the aldehyde dehydrogenase family
I6I52_RS04795	COG1309	transcriptional regulator
I6I52_RS04800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I52_RS04810	COG1607	acyl-coa hydrolase
I6I52_RS04820	COG2009	succinate dehydrogenase
I6I52_RS04825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I52_RS04830	COG1053	succinate dehydrogenase
I6I52_RS04835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I52_RS04850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I52_RS04855	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I52_RS04870	COG1649	PFAM Uncharacterised BCR, COG1649
I6I52_RS04870	COG0726	polysaccharide deacetylase
I6I52_RS04875	COG1215	transferase activity, transferring glycosyl groups
I6I52_RS04890	COG2268	Band 7 protein
I6I52_RS04895	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I52_RS04905	COG2354	Protein conserved in bacteria
I6I52_RS04910	COG2321	neutral zinc metallopeptidase
I6I52_RS04915	COG0531	amino acid
I6I52_RS04930	COG0321	lipoyl(octanoyl) transferase activity
I6I52_RS04955	COG0500	methyltransferase
I6I52_RS04960	COG0586	Pfam SNARE associated Golgi protein
I6I52_RS04975	COG1054	Belongs to the UPF0176 family
I6I52_RS04985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I52_RS04995	COG0193	aminoacyl-tRNA hydrolase activity
I6I52_RS05005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I52_RS05045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I52_RS05075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I52_RS05085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I52_RS05110	COG1492	cobalamin metabolic process
I6I52_RS05115	COG0175	sulfate reduction
I6I52_RS05125	COG2851	Citrate transporter
I6I52_RS05140	COG3293	Transposase
I6I52_RS05155	COG0439	Biotin carboxylase
I6I52_RS05165	COG0864	Transcriptional regulator
I6I52_RS05175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I52_RS05195	COG1116	anion transmembrane transporter activity
I6I52_RS05205	COG1253	flavin adenine dinucleotide binding
I6I52_RS05225	COG3015	lipoprotein NlpE involved in copper resistance
I6I52_RS05240	COG0829	nickel cation binding
I6I52_RS05245	COG0831	urea catabolic process
I6I52_RS05250	COG0832	Belongs to the urease beta subunit family
I6I52_RS05255	COG0804	urea catabolic process
I6I52_RS05260	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I52_RS05265	COG0830	nickel cation binding
I6I52_RS05270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I52_RS05295	COG0742	ribosomal rna small subunit methyltransferase
I6I52_RS05300	COG0768	penicillin binding
I6I52_RS05315	COG0563	adenylate kinase activity
I6I52_RS05325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I52_RS05330	COG2878	Part of a membrane complex involved in electron transport
I6I52_RS05335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I52_RS05345	COG3384	dioxygenase
I6I52_RS05360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I52_RS05390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I52_RS05400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I52_RS05410	COG1671	Belongs to the UPF0178 family
I6I52_RS05430	COG1136	(ABC) transporter
I6I52_RS05435	COG0658	competence protein
I6I52_RS05435	COG2333	competence protein COMEC
I6I52_RS05455	COG1113	amino acid transport
I6I52_RS05460	COG2828	Protein conserved in bacteria
I6I52_RS05470	COG0142	geranyltranstransferase activity
I6I52_RS05485	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I52_RS05495	COG2814	Major facilitator Superfamily
I6I52_RS05500	COG0745	RESPONSE REGULATOR receiver
I6I52_RS05515	COG0004	ammonium transporteR
I6I52_RS05530	COG0525	valine-tRNA ligase activity
I6I52_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS05545	COG0393	Putative heavy-metal-binding
I6I52_RS05550	COG0393	Putative heavy-metal-binding
I6I52_RS05555	COG1538	Outer membrane efflux protein
I6I52_RS05565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I52_RS05570	COG0671	phosphoesterase, PA-phosphatase related
I6I52_RS05585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I52_RS05590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I52_RS05600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I52_RS05610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I52_RS05615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I52_RS05615	COG1648	precorrin-2 dehydrogenase activity
I6I52_RS05620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I52_RS05630	COG1733	regulation of RNA biosynthetic process
I6I52_RS05655	COG0583	DNA-binding transcription factor activity
I6I52_RS05665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I52_RS05670	COG1773	rubredoxin
I6I52_RS05675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I52_RS05690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I52_RS05710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I52_RS05710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I52_RS05725	COG0523	cobalamin synthesis protein
I6I52_RS05735	COG4681	YaeQ
I6I52_RS05750	COG1649	PFAM Uncharacterised BCR, COG1649
I6I52_RS05750	COG0726	polysaccharide deacetylase
I6I52_RS05755	COG1215	transferase activity, transferring glycosyl groups
I6I52_RS05780	COG0400	carboxylic ester hydrolase activity
I6I52_RS05795	COG0561	phosphatase activity
I6I52_RS05800	COG0242	peptide deformylase activity
I6I52_RS05815	COG2223	nitrite transmembrane transporter activity
I6I52_RS05830	COG3293	Transposase
I6I52_RS05855	COG0306	phosphate transporter
I6I52_RS05875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I52_RS05895	COG4771	TonB-dependent receptor
I6I52_RS05900	COG4771	TonB-dependent receptor
I6I52_RS05915	COG0288	reversible hydration of carbon dioxide
I6I52_RS05925	COG4181	ATPase activity
I6I52_RS05930	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I52_RS05940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I52_RS05950	COG0589	response to stress
I6I52_RS05960	COG0589	response to stress
I6I52_RS05980	COG0505	Belongs to the CarA family
I6I52_RS06000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I52_RS06005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I52_RS06010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I52_RS06030	COG1929	Belongs to the glycerate kinase type-1 family
I6I52_RS06050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I52_RS06075	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I52_RS06080	COG1597	lipid kinase activity
I6I52_RS06095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I52_RS06100	COG0459	protein refolding
I6I52_RS06105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I52_RS06110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I52_RS06115	COG1045	serine acetyltransferase
I6I52_RS06125	COG2188	Transcriptional regulator
I6I52_RS06130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I52_RS06155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I52_RS06160	COG2239	Acts as a magnesium transporter
I6I52_RS06170	COG0501	Belongs to the peptidase M48B family
I6I52_RS06175	COG0739	heme binding
I6I52_RS06175	COG1196	nuclear chromosome segregation
I6I52_RS06175	COG0741	lytic transglycosylase activity
I6I52_RS06180	COG0037	tRNA processing
I6I52_RS06190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I52_RS06195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I52_RS06205	COG0583	DNA-binding transcription factor activity
I6I52_RS06220	COG1131	(ABC) transporter
I6I52_RS06225	COG0842	Transport permease protein
I6I52_RS06230	COG0842	Transport permease protein
I6I52_RS06240	COG0583	DNA-binding transcription factor activity
I6I52_RS06245	COG0473	3-isopropylmalate dehydrogenase activity
I6I52_RS06255	COG0657	acetylesterase activity
I6I52_RS06260	COG4638	Rieske (2fe-2S)
I6I52_RS06265	COG1012	belongs to the aldehyde dehydrogenase family
I6I52_RS06280	COG0475	glutathione-regulated potassium exporter activity
I6I52_RS06280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I52_RS06310	COG1741	Belongs to the pirin family
I6I52_RS06320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I52_RS06325	COG3739	integral membrane protein
I6I52_RS06335	COG0586	Pfam SNARE associated Golgi protein
I6I52_RS06340	COG0302	gtp cyclohydrolase
I6I52_RS06350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I52_RS06355	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I52_RS06355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I52_RS06370	COG0134	indole-3-glycerol-phosphate synthase activity
I6I52_RS06375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I52_RS06380	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I52_RS06435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I52_RS06560	COG3561	AntA/AntB antirepressor
I6I52_RS06665	COG0582	viral genome integration into host DNA
I6I52_RS06670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I52_RS06675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I52_RS06680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I52_RS06685	COG1067	ATP-dependent peptidase activity
I6I52_RS06700	COG0254	rRNA binding
I6I52_RS06705	COG0583	DNA-binding transcription factor activity
I6I52_RS06710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I52_RS06715	COG4208	sulfate ABC transporter
I6I52_RS06720	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I52_RS06730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I52_RS06735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I52_RS06740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I52_RS06745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I52_RS06755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I52_RS06760	COG0174	glutamine synthetase
I6I52_RS06770	COG0481	GTPase activity
I6I52_RS06775	COG0681	Belongs to the peptidase S26 family
I6I52_RS06785	COG0571	ribonuclease III activity
I6I52_RS06790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I52_RS06800	COG1381	Involved in DNA repair and RecF pathway recombination
I6I52_RS06805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I52_RS06825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I52_RS06835	COG1301	dicarboxylic acid transport
I6I52_RS06855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I52_RS06860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I52_RS06880	COG3634	alkyl hydroperoxide reductase activity
I6I52_RS06885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I52_RS06895	COG3384	dioxygenase
I6I52_RS06900	COG1335	isochorismatase
I6I52_RS06910	COG1720	tRNA m6t6A37 methyltransferase activity
I6I52_RS06915	COG3706	GGDEF domain
I6I52_RS06920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I52_RS06925	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I52_RS06935	COG0642	Histidine kinase
I6I52_RS06945	COG0494	nUDIX hydrolase
I6I52_RS06955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I52_RS06960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I52_RS06965	COG3139	Protein of unknown function (DUF1315)
I6I52_RS06970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I52_RS06975	COG1301	dicarboxylic acid transport
I6I52_RS06985	COG0659	secondary active sulfate transmembrane transporter activity
I6I52_RS06995	COG2252	PERMEase
I6I52_RS07000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I52_RS07015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I52_RS07030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I52_RS07045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I52_RS07050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I52_RS07065	COG0667	Aldo Keto reductase
I6I52_RS07075	COG1765	OsmC-like protein
I6I52_RS07100	COG0116	Belongs to the methyltransferase superfamily
I6I52_RS07100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I52_RS07105	COG0540	Belongs to the ATCase OTCase family
I6I52_RS07135	COG2995	paraquat-inducible protein a
I6I52_RS07140	COG3008	intermembrane lipid transfer
I6I52_RS07140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I52_RS07150	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I52_RS07150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I52_RS07160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I52_RS07160	COG3323	Protein of unknown function (DUF1653)
I6I52_RS07170	COG1024	Enoyl-CoA hydratase
I6I52_RS07175	COG1056	cytidyltransferase-related domain
I6I52_RS07175	COG1051	belongs to the nudix hydrolase family
I6I52_RS07180	COG2353	YceI-like domain
I6I52_RS07185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I52_RS07195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I52_RS07200	COG0602	queuosine metabolic process
I6I52_RS07210	COG4625	pathogenesis
I6I52_RS07225	COG1509	lysine 2,3-aminomutase activity
I6I52_RS07230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I52_RS07235	COG1966	Carbon starvation protein
I6I52_RS07240	COG2879	small protein
I6I52_RS07245	COG0714	Associated with various cellular activities
I6I52_RS07255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I52_RS07265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I52_RS07275	COG0596	Alpha beta hydrolase
I6I52_RS07280	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I52_RS07320	COG0436	Aminotransferase
I6I52_RS07325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I52_RS07330	COG0386	Belongs to the glutathione peroxidase family
I6I52_RS07365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I52_RS07370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I52_RS07390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I52_RS07395	COG0012	GTP binding
I6I52_RS07400	COG2011	ABC-type metal ion transport system permease component
I6I52_RS07405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I52_RS07410	COG1464	Belongs to the NlpA lipoprotein family
I6I52_RS07435	COG1012	belongs to the aldehyde dehydrogenase family
I6I52_RS07440	COG0471	metal ion transport
I6I52_RS07445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I52_RS07450	COG2814	Major facilitator Superfamily
I6I52_RS07460	COG0583	DNA-binding transcription factor activity
I6I52_RS07470	COG2707	UPF0756 membrane protein
I6I52_RS07480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I52_RS07510	COG0564	pseudouridine synthase activity
I6I52_RS07515	COG0802	atpase or kinase
I6I52_RS07520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I52_RS07525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I52_RS07530	COG1923	regulation of RNA biosynthetic process
I6I52_RS07535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I52_RS07540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I52_RS07550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I52_RS07555	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I52_RS07560	COG1192	Involved in chromosome partitioning
I6I52_RS07565	COG1475	DNA binding
I6I52_RS07570	COG0811	peptide transport
I6I52_RS07580	COG1132	(ABC) transporter
I6I52_RS07585	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I52_RS07605	COG0084	hydrolase, TatD family'
I6I52_RS07660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I52_RS07670	COG0776	regulation of translation
I6I52_RS07685	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I52_RS07705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I52_RS07725	COG1253	flavin adenine dinucleotide binding
I6I52_RS07740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I52_RS07750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I52_RS07755	COG0730	response to heat
I6I52_RS07780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I52_RS07815	COG0515	serine threonine protein kinase
I6I52_RS07815	COG2815	serine threonine protein kinase
I6I52_RS07855	COG2011	ABC-type metal ion transport system permease component
I6I52_RS07860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I52_RS07865	COG1464	Belongs to the NlpA lipoprotein family
I6I52_RS07875	COG0138	bifunctional purine biosynthesis protein purh
I6I52_RS07880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I52_RS07905	COG0445	tRNA wobble uridine modification
I6I52_RS07915	COG2308	Evidence 4 Homologs of previously reported genes of
I6I52_RS07925	COG1305	Transglutaminase-like
I6I52_RS07940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I52_RS07945	COG0305	Participates in initiation and elongation during chromosome replication
I6I52_RS07950	COG0517	IMP dehydrogenase activity
I6I52_RS07950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I52_RS07985	COG0552	protein localization to endoplasmic reticulum
I6I52_RS08005	COG4890	Cyd operon protein YbgT
I6I52_RS08010	COG1294	oxidase, subunit
I6I52_RS08025	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I52_RS08035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I52_RS08050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I52_RS08055	COG0569	domain protein
I6I52_RS08060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I52_RS08065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I52_RS08080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I52_RS08090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I52_RS08095	COG0542	response to heat
I6I52_RS08120	COG0765	amino acid transport
I6I52_RS08125	COG0765	amino acid transport
I6I52_RS08130	COG1126	abc transporter atp-binding protein
I6I52_RS08145	COG0217	transcriptional regulatory protein
I6I52_RS08160	COG4774	siderophore transport
I6I52_RS08165	COG2193	ferroxidase activity
I6I52_RS08225	COG0582	viral genome integration into host DNA
I6I52_RS08240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I52_RS08250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I52_RS08250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I52_RS08280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I52_RS08285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I52_RS08300	COG2353	YceI-like domain
I6I52_RS08310	COG0505	Belongs to the CarA family
I6I52_RS08330	COG1454	alcohol dehydrogenase
I6I52_RS08335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I52_RS08345	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I52_RS08350	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I52_RS08365	COG0308	aminopeptidase N
I6I52_RS08375	COG0589	response to stress
I6I52_RS08390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I52_RS08400	COG3135	benzoate transporter
I6I52_RS08410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I52_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS08445	COG2030	dehydratase
I6I52_RS08450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I52_RS08475	COG0824	Thioesterase
I6I52_RS08480	COG1454	alcohol dehydrogenase
I6I52_RS08485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I52_RS08490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I52_RS08510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I52_RS08540	COG0316	Belongs to the HesB IscA family
I6I52_RS08545	COG0822	iron-sulfur transferase activity
I6I52_RS08575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I52_RS08585	COG3328	transposase activity
I6I52_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS08595	COG1414	Transcriptional regulator
I6I52_RS08620	COG3659	wide pore channel activity
I6I52_RS08625	COG1309	transcriptional regulator
I6I52_RS08645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I52_RS08655	COG1053	succinate dehydrogenase
I6I52_RS08660	COG1053	succinate dehydrogenase
I6I52_RS08670	COG0667	Aldo Keto reductase
I6I52_RS08680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I52_RS08685	COG2814	Major facilitator Superfamily
I6I52_RS08745	COG0024	Methionine aminopeptidase
I6I52_RS08750	COG0583	DNA-binding transcription factor activity
I6I52_RS08755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I52_RS08765	COG0583	DNA-binding transcription factor activity
I6I52_RS08770	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS08775	COG2814	Major facilitator Superfamily
I6I52_RS08780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I52_RS08815	COG3676	manually curated
I6I52_RS08820	COG3328	transposase activity
I6I52_RS08825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I52_RS08835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I52_RS08845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I52_RS08860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I52_RS08875	COG1346	cytolysis
I6I52_RS08880	COG1380	Effector of murein hydrolase LrgA
I6I52_RS08885	COG0583	DNA-binding transcription factor activity
I6I52_RS08935	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I52_RS08935	COG0644	oxidoreductase
I6I52_RS08940	COG2814	Major facilitator Superfamily
I6I52_RS08955	COG2814	Major facilitator Superfamily
I6I52_RS08970	COG0183	Belongs to the thiolase family
I6I52_RS08975	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I52_RS08980	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS08985	COG1024	Enoyl-CoA hydratase
I6I52_RS08990	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS08995	COG2814	Major facilitator Superfamily
I6I52_RS09000	COG2814	Major facilitator Superfamily
I6I52_RS09010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I52_RS09020	COG2814	Major facilitator Superfamily
I6I52_RS09030	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS09035	COG1024	Enoyl-CoA hydratase
I6I52_RS09040	COG0235	Class ii aldolase
I6I52_RS09045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I52_RS09050	COG0583	DNA-binding transcription factor activity
I6I52_RS09055	COG0477	Major facilitator Superfamily
I6I52_RS09060	COG1414	Transcriptional regulator
I6I52_RS09065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I52_RS09070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I52_RS09075	COG0183	Belongs to the thiolase family
I6I52_RS09080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I52_RS09085	COG0596	Alpha beta hydrolase
I6I52_RS09090	COG2271	Major facilitator Superfamily
I6I52_RS09095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I52_RS09100	COG3485	protocatechuate 3,4-dioxygenase
I6I52_RS09105	COG3485	protocatechuate 3,4-dioxygenase
I6I52_RS09110	COG0710	3-dehydroquinate dehydratase activity
I6I52_RS09115	COG3420	alginic acid biosynthetic process
I6I52_RS09120	COG3659	wide pore channel activity
I6I52_RS09125	COG4993	Dehydrogenase
I6I52_RS09130	COG1414	Transcriptional regulator
I6I52_RS09135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I52_RS09145	COG3676	manually curated
I6I52_RS09155	COG1846	Transcriptional regulator
I6I52_RS09160	COG0583	DNA-binding transcription factor activity
I6I52_RS09165	COG1027	Aspartate ammonia-lyase
I6I52_RS09175	COG1595	DNA-templated transcription, initiation
I6I52_RS09180	COG1538	Outer membrane efflux protein
I6I52_RS09225	COG0640	Transcriptional regulator
I6I52_RS09240	COG3122	Protein conserved in bacteria
I6I52_RS09245	COG0668	transmembrane transport
I6I52_RS09250	COG1132	(ABC) transporter
I6I52_RS09265	COG0509	glycine decarboxylation via glycine cleavage system
I6I52_RS09270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I52_RS09275	COG0488	(ABC) transporter
I6I52_RS09280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I52_RS09290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I52_RS09330	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS09340	COG2194	sulfuric ester hydrolase activity
I6I52_RS09360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I52_RS09365	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I52_RS09385	COG0697	spore germination
I6I52_RS09390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I52_RS09400	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I52_RS09405	COG0303	'Molybdopterin
I6I52_RS09410	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I52_RS09410	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I52_RS09425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I52_RS09435	COG0243	molybdopterin cofactor binding
I6I52_RS09440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I52_RS09445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I52_RS09450	COG2223	nitrite transmembrane transporter activity
I6I52_RS09455	COG0745	RESPONSE REGULATOR receiver
I6I52_RS09460	COG1116	anion transmembrane transporter activity
I6I52_RS09460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I52_RS09470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I52_RS09475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I52_RS09485	COG0148	phosphopyruvate hydratase activity
I6I52_RS09495	COG0504	CTP synthase activity
I6I52_RS09515	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I52_RS09515	COG1902	pentaerythritol trinitrate reductase activity
I6I52_RS09525	COG2267	carboxylic ester hydrolase activity
I6I52_RS09530	COG0477	Major facilitator Superfamily
I6I52_RS09535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I52_RS09540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I52_RS09550	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I52_RS09550	COG0506	proline dehydrogenase activity
I6I52_RS09550	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I52_RS09555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I52_RS09560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I52_RS09570	COG3698	Phosphodiester glycosidase
I6I52_RS09605	COG0697	spore germination
I6I52_RS09610	COG0191	fructose-bisphosphate aldolase activity
I6I52_RS09620	COG0126	phosphoglycerate kinase activity
I6I52_RS09630	COG0424	maF-like protein
I6I52_RS09640	COG2850	peptidyl-arginine hydroxylation
I6I52_RS09645	COG0069	glutamate synthase activity
I6I52_RS09660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I52_RS09665	COG0702	epimerase
I6I52_RS09670	COG0268	Binds directly to 16S ribosomal RNA
I6I52_RS09675	COG3594	Acyltransferase
I6I52_RS09685	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I52_RS09690	COG1011	Hydrolase
I6I52_RS09695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I52_RS09700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I52_RS09705	COG2137	regulation of response to DNA damage stimulus
I6I52_RS09720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I52_RS09730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I52_RS09755	COG0575	Belongs to the CDS family
I6I52_RS09760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I52_RS09765	COG0233	cytoplasmic translational termination
I6I52_RS09770	COG0528	UMP kinase activity
I6I52_RS09780	COG3852	Histidine kinase
I6I52_RS09785	COG2204	response regulator
I6I52_RS09795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I52_RS09800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I52_RS09845	COG0729	surface antigen
I6I52_RS09855	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I52_RS09865	COG0745	RESPONSE REGULATOR receiver
I6I52_RS09870	COG2205	protein histidine kinase activity
I6I52_RS09880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I52_RS09885	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I52_RS09895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I52_RS09920	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS09925	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS09935	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I52_RS09940	COG2207	Transcriptional regulator
I6I52_RS09965	COG1968	undecaprenyl-diphosphatase activity
I6I52_RS09970	COG3042	response to heat
I6I52_RS10005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I52_RS10010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I52_RS10025	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I52_RS10030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I52_RS10040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I52_RS10045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I52_RS10060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I52_RS10065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I52_RS10070	COG1845	cytochrome c oxidase, subunit III
I6I52_RS10075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I52_RS10085	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I52_RS10090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I52_RS10105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I52_RS10115	COG3100	YcgL domain-containing protein
I6I52_RS10125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I52_RS10155	COG0537	adenosine 5'-monophosphoramidase activity
I6I52_RS10175	COG1610	YqeY-like protein
I6I52_RS10185	COG4783	chaperone-mediated protein folding
I6I52_RS10210	COG1286	toxin biosynthetic process
I6I52_RS10215	COG0167	dihydroorotate dehydrogenase activity
I6I52_RS10240	COG0778	Nitroreductase
I6I52_RS10250	COG0513	Belongs to the DEAD box helicase family
I6I52_RS10310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I52_RS10315	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS10325	COG3706	GGDEF domain
I6I52_RS10335	COG4716	Myosin-crossreactive antigen
I6I52_RS10350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I52_RS10355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I52_RS10360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I52_RS10380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I52_RS10385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I52_RS10390	COG0583	DNA-binding transcription factor activity
I6I52_RS10400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I52_RS10415	COG1686	Belongs to the peptidase S11 family
I6I52_RS10420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I52_RS10430	COG0482	sulfurtransferase activity
I6I52_RS10435	COG2915	High frequency lysogenization protein hflD homolog
I6I52_RS10450	COG0616	signal peptide processing
I6I52_RS10455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I52_RS10465	COG0573	inorganic phosphate transmembrane transporter activity
I6I52_RS10470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I52_RS10475	COG0076	glutamate decarboxylase activity
I6I52_RS10480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I52_RS10500	COG1309	transcriptional regulator
I6I52_RS10505	COG0783	Belongs to the Dps family
I6I52_RS10515	COG0564	pseudouridine synthase activity
I6I52_RS10520	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6I52_RS10530	COG0352	thiamine-phosphate diphosphorylase activity
I6I52_RS10540	COG1686	Belongs to the peptidase S11 family
I6I52_RS10550	COG0589	response to stress
I6I52_RS10560	COG0671	phosphoesterase, PA-phosphatase related
I6I52_RS10570	COG2194	sulfuric ester hydrolase activity
I6I52_RS10575	COG0745	RESPONSE REGULATOR receiver
I6I52_RS10595	COG3328	transposase activity
I6I52_RS10695	COG0737	Belongs to the 5'-nucleotidase family
I6I52_RS10710	COG0431	NADPH-dependent FMN reductase
I6I52_RS10715	COG0798	PFAM Bile acid sodium symporter
I6I52_RS10725	COG0640	Transcriptional regulator
I6I52_RS10755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I52_RS10760	COG0730	response to heat
I6I52_RS10780	COG0640	Transcriptional regulator
I6I52_RS10785	COG1136	(ABC) transporter
I6I52_RS10795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I52_RS10800	COG3177	Filamentation induced by cAMP protein fic
I6I52_RS10810	COG1401	restriction endodeoxyribonuclease activity
I6I52_RS10815	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6I52_RS10815	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6I52_RS10825	COG3586	endonuclease activity
I6I52_RS10925	COG0582	viral genome integration into host DNA
I6I52_RS10935	COG1131	(ABC) transporter
I6I52_RS10940	COG0842	Transport permease protein
I6I52_RS10945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I52_RS10945	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I52_RS10955	COG0772	Belongs to the SEDS family
I6I52_RS10960	COG2951	lytic endotransglycosylase activity
I6I52_RS10995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I52_RS11000	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I52_RS11005	COG0024	Methionine aminopeptidase
I6I52_RS11020	COG2175	clavaminate synthase activity
I6I52_RS11030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I52_RS11045	COG4372	Transposase
I6I52_RS11065	COG4969	Belongs to the N-Me-Phe pilin family
I6I52_RS11090	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6I52_RS11100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I52_RS11110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I52_RS11120	COG4122	O-methyltransferase activity
I6I52_RS11180	COG1137	ATPase activity
I6I52_RS11185	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I52_RS11195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I52_RS11215	COG4993	Dehydrogenase
I6I52_RS11220	COG2175	clavaminate synthase activity
I6I52_RS11225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I52_RS11230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I52_RS11235	COG4521	taurine ABC transporter
I6I52_RS11250	COG2255	four-way junction helicase activity
I6I52_RS11255	COG0824	Thioesterase
I6I52_RS11275	COG0823	Involved in the tonB-independent uptake of proteins
I6I52_RS11295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I52_RS11315	COG2203	Gaf domain
I6I52_RS11315	COG3706	GGDEF domain
I6I52_RS11315	COG4251	negative regulation of phosphorylation
I6I52_RS11315	COG5001	Diguanylate cyclase
I6I52_RS11320	COG0418	dihydroorotase activity
I6I52_RS11325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I52_RS11335	COG0833	amino acid
I6I52_RS11345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I52_RS11350	COG0243	molybdopterin cofactor binding
I6I52_RS11360	COG1643	Atp-dependent helicase
I6I52_RS11405	COG3022	response to hydroperoxide
I6I52_RS11410	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I52_RS11420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I52_RS11440	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS11455	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6I52_RS11470	COG2985	domain, Protein
I6I52_RS11475	COG1764	response to oxidative stress
I6I52_RS11500	COG0632	four-way junction helicase activity
I6I52_RS11505	COG4302	ethanolamine ammonia-lyase activity
I6I52_RS11510	COG4303	Ethanolamine ammonia lyase large subunit
I6I52_RS11515	COG0531	amino acid
I6I52_RS11520	COG2070	2-Nitropropane dioxygenase
I6I52_RS11530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I52_RS11545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I52_RS11570	COG2962	Rard protein
I6I52_RS11575	COG3040	lipid binding
I6I52_RS11580	COG0556	nucleotide-excision repair
I6I52_RS11590	COG2199	diguanylate cyclase activity
I6I52_RS11595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I52_RS11605	COG0436	Aminotransferase
I6I52_RS11620	COG0174	glutamine synthetase
I6I52_RS11655	COG1802	Transcriptional regulator
I6I52_RS11675	COG1522	sequence-specific DNA binding
I6I52_RS11725	COG0612	Peptidase, M16
I6I52_RS11730	COG0038	chloride channel
I6I52_RS11740	COG1823	symporter activity
I6I52_RS11750	COG1187	pseudouridine synthase activity
I6I52_RS11760	COG2351	hydroxyisourate hydrolase activity
I6I52_RS11780	COG4172	Belongs to the ABC transporter superfamily
I6I52_RS11785	COG4239	(ABC) transporter, permease
I6I52_RS11790	COG4174	ABC transporter (Permease)
I6I52_RS11795	COG4166	transmembrane transport
I6I52_RS11800	COG1388	LysM domain
I6I52_RS11800	COG0741	lytic transglycosylase activity
I6I52_RS11800	COG1388	LysM domain
I6I52_RS11800	COG0741	lytic transglycosylase activity
I6I52_RS11805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I52_RS11830	COG0792	nuclease activity
I6I52_RS11835	COG3107	peptidoglycan biosynthetic process
I6I52_RS11850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I52_RS11855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I52_RS11860	COG0006	proline dipeptidase activity
I6I52_RS11865	COG3079	Belongs to the UPF0149 family
I6I52_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS11920	COG2217	Heavy metal translocating P-type atpase
I6I52_RS11945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I52_RS11950	COG2267	carboxylic ester hydrolase activity
I6I52_RS11960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I52_RS11975	COG1113	amino acid transport
I6I52_RS11995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I52_RS12000	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6I52_RS12025	COG1309	transcriptional regulator
I6I52_RS12035	COG2814	Major facilitator Superfamily
I6I52_RS12040	COG1024	Enoyl-CoA hydratase
I6I52_RS12045	COG1012	belongs to the aldehyde dehydrogenase family
I6I52_RS12055	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS12080	COG1595	DNA-templated transcription, initiation
I6I52_RS12095	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS12100	COG2610	gluconate transmembrane transporter activity
I6I52_RS12105	COG0583	DNA-binding transcription factor activity
I6I52_RS12120	COG2031	fatty acid transporter
I6I52_RS12125	COG0183	Belongs to the thiolase family
I6I52_RS12130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I52_RS12135	COG4149	molybdate abc transporter
I6I52_RS12140	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I52_RS12155	COG0477	Major facilitator Superfamily
I6I52_RS12160	COG0583	DNA-binding transcription factor activity
I6I52_RS12165	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS12170	COG2301	Belongs to the HpcH HpaI aldolase family
I6I52_RS12175	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I52_RS12200	COG0596	Alpha beta hydrolase
I6I52_RS12205	COG0583	DNA-binding transcription factor activity
I6I52_RS12215	COG4974	Belongs to the 'phage' integrase family
I6I52_RS12240	COG1902	pentaerythritol trinitrate reductase activity
I6I52_RS12240	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I52_RS12245	COG0697	spore germination
I6I52_RS12250	COG0583	DNA-binding transcription factor activity
I6I52_RS12285	COG0628	permease
I6I52_RS12290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I52_RS12295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I52_RS12310	COG4372	Transposase
I6I52_RS12360	COG0717	Belongs to the dCTP deaminase family
I6I52_RS12375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I52_RS12380	COG0489	protein tyrosine kinase activity
I6I52_RS12390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I52_RS12390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I52_RS12395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I52_RS12430	COG1280	lysine exporter protein (LysE YggA)
I6I52_RS12435	COG2226	methyltransferase
I6I52_RS12455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I52_RS12460	COG2081	HI0933 family
I6I52_RS12470	COG0668	transmembrane transport
I6I52_RS12490	COG0583	DNA-binding transcription factor activity
I6I52_RS12505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I52_RS12515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I52_RS12520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I52_RS12525	COG0713	ATP synthesis coupled electron transport
I6I52_RS12535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I52_RS12550	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I52_RS12560	COG0649	NAD binding
I6I52_RS12560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I52_RS12565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I52_RS12570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I52_RS12580	COG2205	protein histidine kinase activity
I6I52_RS12585	COG0745	RESPONSE REGULATOR receiver
I6I52_RS12590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I52_RS12590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I52_RS12600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I52_RS12605	COG1074	ATP-dependent DNA helicase activity
I6I52_RS12640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I52_RS12665	COG2132	Multicopper oxidase
I6I52_RS12675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I52_RS12690	COG4269	membrane
I6I52_RS12705	COG0742	ribosomal rna small subunit methyltransferase
I6I52_RS12710	COG1968	undecaprenyl-diphosphatase activity
I6I52_RS12715	COG1214	PFAM Peptidase M22, glycoprotease
I6I52_RS12775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I52_RS12785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I52_RS12790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I52_RS12850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I52_RS12855	COG1846	Transcriptional regulator
I6I52_RS12895	COG0037	tRNA processing
I6I52_RS12905	COG0248	Ppx GppA phosphatase
I6I52_RS12925	COG0776	regulation of translation
I6I52_RS12930	COG0072	phenylalanine-tRNA ligase activity
I6I52_RS12935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I52_RS12960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I52_RS12975	COG1238	metal cluster binding
I6I52_RS12980	COG0625	glutathione transferase activity
I6I52_RS12990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I52_RS12995	COG0318	PFAM AMP-dependent synthetase and ligase
I6I52_RS13000	COG3028	Belongs to the UPF0307 family
I6I52_RS13005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I52_RS13010	COG1660	Displays ATPase and GTPase activities
I6I52_RS13015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I52_RS13025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I52_RS13030	COG0617	tRNA 3'-terminal CCA addition
I6I52_RS13035	COG1555	photosystem II stabilization
I6I52_RS13040	COG3956	TIGRFAM MazG family protein
I6I52_RS13055	COG2315	Protein conserved in bacteria
I6I52_RS13060	COG0745	RESPONSE REGULATOR receiver
I6I52_RS13065	COG2205	protein histidine kinase activity
I6I52_RS13075	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS13080	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS13130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I52_RS13145	COG1442	glycosyl transferase family 8
I6I52_RS13160	COG0438	transferase activity, transferring glycosyl groups
I6I52_RS13170	COG0438	transferase activity, transferring glycosyl groups
I6I52_RS13175	COG0726	polysaccharide deacetylase
I6I52_RS13190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I52_RS13195	COG2205	protein histidine kinase activity
I6I52_RS13200	COG3706	GGDEF domain
I6I52_RS13230	COG0697	spore germination
I6I52_RS13235	COG0789	Transcriptional regulator
I6I52_RS13245	COG2814	Major facilitator Superfamily
I6I52_RS13255	COG1230	cation diffusion facilitator family transporter
I6I52_RS13270	COG4774	siderophore transport
I6I52_RS13295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I52_RS13305	COG1477	protein flavinylation
I6I52_RS13350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I52_RS13365	COG0732	type I restriction modification DNA specificity domain
I6I52_RS13375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I52_RS13415	COG1431	PFAM Stem cell self-renewal protein Piwi
I6I52_RS13455	COG3328	transposase activity
I6I52_RS13520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I52_RS13530	COG1704	LemA family
I6I52_RS13540	COG1862	Preprotein translocase
I6I52_RS13570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I52_RS13575	COG1028	Short-chain dehydrogenase reductase Sdr
I6I52_RS13595	COG0644	oxidoreductase
I6I52_RS13615	COG2986	histidine ammonia-lyase
I6I52_RS13630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I52_RS13640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I52_RS13675	COG0124	histidyl-tRNA synthetase
I6I52_RS13700	COG0105	UTP biosynthetic process
I6I52_RS13720	COG0793	Belongs to the peptidase S41A family
I6I52_RS13735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I52_RS13740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I52_RS13745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I52_RS13750	COG0857	belongs to the CobB CobQ family
I6I52_RS13750	COG0280	phosphate acetyltransferase
I6I52_RS13755	COG1335	isochorismatase
I6I52_RS13765	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I52_RS13765	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I52_RS13775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I52_RS13780	COG1162	GTPase activity
I6I52_RS13790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I52_RS13800	COG3783	Cytochrome b(562)
I6I52_RS13805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I52_RS13810	COG2003	Belongs to the UPF0758 family
I6I52_RS13815	COG3781	membrane
I6I52_RS13820	COG0667	Aldo Keto reductase
I6I52_RS13825	COG0583	DNA-binding transcription factor activity
I6I52_RS13840	COG2350	Protein conserved in bacteria
I6I52_RS13855	COG0560	Phosphoserine phosphatase
I6I52_RS13865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I52_RS13875	COG1530	ribonuclease E activity
I6I52_RS13880	COG0424	maF-like protein
I6I52_RS13890	COG1792	Involved in formation and maintenance of cell shape
I6I52_RS13895	COG1077	Cell shape determining protein MreB Mrl
I6I52_RS13900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I52_RS13905	COG0154	amidase activity
I6I52_RS13910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I52_RS13965	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I52_RS14000	COG1902	pentaerythritol trinitrate reductase activity
I6I52_RS14005	COG4772	TonB-dependent receptor
I6I52_RS14010	COG2094	Belongs to the DNA glycosylase MPG family
I6I52_RS14015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I52_RS14035	COG1217	gtp-binding protein TYPA
I6I52_RS14040	COG2233	PERMEase
I6I52_RS14045	COG2813	Specifically methylates the guanine in position
I6I52_RS14050	COG0833	amino acid
I6I52_RS14055	COG1690	Belongs to the RtcB family
I6I52_RS14070	COG2198	Histidine kinase
I6I52_RS14070	COG0643	Histidine kinase
I6I52_RS14075	COG0840	transmembrane signaling receptor activity
I6I52_RS14110	COG0442	prolyl-tRNA aminoacylation
I6I52_RS14120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I52_RS14140	COG2207	Transcriptional regulator
I6I52_RS14155	COG0183	Belongs to the thiolase family
I6I52_RS14170	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I52_RS14180	COG2153	protein acetylation
I6I52_RS14190	COG1272	protein, Hemolysin III
I6I52_RS14195	COG0477	Major facilitator Superfamily
I6I52_RS14200	COG1408	metallophosphoesterase
I6I52_RS14205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I52_RS14220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I52_RS14240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I52_RS14245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I52_RS14250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I52_RS14260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I52_RS14265	COG0625	glutathione transferase activity
I6I52_RS14270	COG2969	positive regulation of protein catabolic process
I6I52_RS14295	COG3328	transposase activity
I6I52_RS14335	COG1183	phosphatidylcholine synthase activity
I6I52_RS14340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I52_RS14360	COG0039	L-malate dehydrogenase activity
I6I52_RS14370	COG1196	nuclear chromosome segregation
I6I52_RS14370	COG0741	lytic transglycosylase activity
I6I52_RS14370	COG0739	heme binding
I6I52_RS14375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I52_RS14380	COG1702	phosphate starvation-inducible protein PhoH
I6I52_RS14385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I52_RS14420	COG1295	ribonuclease BN
I6I52_RS14435	COG0583	DNA-binding transcription factor activity
I6I52_RS14440	COG2814	Major facilitator Superfamily
I6I52_RS14450	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I52_RS14495	COG0557	exoribonuclease II activity
I6I52_RS14505	COG0339	signal peptide processing
I6I52_RS14510	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I52_RS14540	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I52_RS14545	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS14550	COG2072	flavoprotein involved in K transport
I6I52_RS14555	COG0203	ribosomal protein L17
I6I52_RS14560	COG0202	RNA polymerase activity
I6I52_RS14565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I52_RS14575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I52_RS14600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I52_RS14610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I52_RS14615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I52_RS14625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I52_RS14630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I52_RS14635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I52_RS14640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I52_RS14650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I52_RS14660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I52_RS14665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I52_RS14680	COG0088	Forms part of the polypeptide exit tunnel
I6I52_RS14685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I52_RS14690	COG0051	transcription antitermination factor activity, RNA binding
I6I52_RS14705	COG0433	COG0433 Predicted ATPase
I6I52_RS14710	COG1017	nitric oxide dioxygenase activity
I6I52_RS14710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I52_RS14715	COG1959	2 iron, 2 sulfur cluster binding
I6I52_RS14730	COG1301	dicarboxylic acid transport
I6I52_RS14735	COG1946	Acyl-CoA thioesterase
I6I52_RS14740	COG2937	Belongs to the GPAT DAPAT family
I6I52_RS14755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I52_RS14760	COG1040	competence protein
I6I52_RS14765	COG0494	nUDIX hydrolase
I6I52_RS14775	COG0598	Magnesium transport protein CorA
I6I52_RS14795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I52_RS14800	COG1127	ABC transporter
I6I52_RS14805	COG0513	Belongs to the DEAD box helicase family
I6I52_RS14820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I52_RS14825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I52_RS14830	COG0408	coproporphyrinogen oxidase activity
I6I52_RS14840	COG2885	chlorophyll binding
I6I52_RS14855	COG1960	acyl-CoA dehydrogenase activity
I6I52_RS14865	COG1983	PspC domain protein
I6I52_RS14870	COG0517	IMP dehydrogenase activity
I6I52_RS14885	COG0752	glycyl-tRNA synthetase alpha subunit
I6I52_RS14905	COG0583	DNA-binding transcription factor activity
I6I52_RS14920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I52_RS14965	COG1192	Involved in chromosome partitioning
I6I52_RS14970	COG0628	permease
I6I52_RS14995	COG1289	transmembrane transporter activity
I6I52_RS15000	COG2814	Major facilitator Superfamily
I6I52_RS15010	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I52_RS15015	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I52_RS15030	COG0277	FAD linked oxidase domain protein
I6I52_RS15035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I52_RS15040	COG5006	permease, DMT superfamily
I6I52_RS15060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I52_RS15065	COG5380	lipid catabolic process
I6I52_RS15070	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6I52_RS15075	COG0335	large ribosomal subunit rRNA binding
I6I52_RS15085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I52_RS15090	COG0228	four-way junction DNA binding
I6I52_RS15135	COG0194	GDP metabolic process
I6I52_RS15140	COG1758	RNA polymerase activity
I6I52_RS15145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I52_RS15170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I52_RS15200	COG0326	Molecular chaperone. Has ATPase activity
I6I52_RS15235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I52_RS15240	COG0085	RNA polymerase activity
I6I52_RS15255	COG0081	regulation of translation
I6I52_RS15260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I52_RS15280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I52_RS15315	COG1716	ATPase activity
I6I52_RS15360	COG0181	hydroxymethylbilane synthase activity
I6I52_RS15370	COG3275	phosphorelay sensor kinase activity
I6I52_RS15400	COG0494	nUDIX hydrolase
I6I52_RS15405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I52_RS15410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I52_RS15415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I52_RS15420	COG0772	Belongs to the SEDS family
I6I52_RS15425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I52_RS15445	COG4974	Belongs to the 'phage' integrase family
I6I52_RS15450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I52_RS15460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I52_RS15470	COG2197	response regulator
I6I52_RS15485	COG0793	Belongs to the peptidase S41A family
I6I52_RS15490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I52_RS15495	COG0795	lipopolysaccharide-transporting ATPase activity
I6I52_RS15500	COG0795	lipopolysaccharide-transporting ATPase activity
I6I52_RS15535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I52_RS15535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I52_RS15545	COG0004	ammonium transporteR
I6I52_RS15550	COG0347	Belongs to the P(II) protein family
I6I52_RS15560	COG0606	chelatase, subunit chli
I6I52_RS15575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I52_RS15590	COG0318	PFAM AMP-dependent synthetase and ligase
I6I52_RS15600	COG0477	Major facilitator Superfamily
I6I52_RS15610	COG2860	membrane
I6I52_RS15620	COG1253	flavin adenine dinucleotide binding
I6I52_RS15640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I52_RS15645	COG0477	Major facilitator Superfamily
I6I52_RS15695	COG1309	transcriptional regulator
I6I52_RS15725	COG1652	LysM domain
I6I52_RS15730	COG0758	DNA mediated transformation
I6I52_RS15735	COG0009	L-threonylcarbamoyladenylate synthase
I6I52_RS15740	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I52_RS15745	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I52_RS15750	COG3845	ABC transporter
I6I52_RS15790	COG0697	spore germination
I6I52_RS15795	COG1309	transcriptional regulator
I6I52_RS15800	COG2814	Major facilitator Superfamily
I6I52_RS15810	COG0386	Belongs to the glutathione peroxidase family
I6I52_RS15835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I52_RS15840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I52_RS15870	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I52_RS15890	COG1121	(ABC) transporter
I6I52_RS15895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I52_RS15900	COG1280	lysine exporter protein (LysE YggA)
I6I52_RS15915	COG1388	LysM domain
I6I52_RS15915	COG0791	NLP P60 protein
I6I52_RS15925	COG0281	malic enzyme
I6I52_RS15970	COG0735	belongs to the Fur family
I6I52_RS15995	COG0640	Transcriptional regulator
I6I52_RS16005	COG0798	PFAM Bile acid sodium symporter
I6I52_RS16010	COG0431	NADPH-dependent FMN reductase
I6I52_RS16015	COG0492	ferredoxin-NADP+ reductase activity
I6I52_RS16035	COG0583	DNA-binding transcription factor activity
I6I52_RS16045	COG2233	PERMEase
I6I52_RS16065	COG0583	DNA-binding transcription factor activity
I6I52_RS16150	COG2217	Heavy metal translocating P-type atpase
I6I52_RS16160	COG2205	protein histidine kinase activity
I6I52_RS16175	COG2132	Multicopper oxidase
I6I52_RS16215	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I52_RS16215	COG3264	Mechanosensitive ion channel
I6I52_RS16235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I52_RS16280	COG0542	response to heat
I6I52_RS16290	COG2072	flavoprotein involved in K transport
I6I52_RS16300	COG2144	transferase activity, transferring acyl groups
I6I52_RS16325	COG3604	Transcriptional regulator
I6I52_RS16360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I52_RS16370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I52_RS16375	COG1113	amino acid transport
I6I52_RS16380	COG0697	spore germination
I6I52_RS16385	COG0582	viral genome integration into host DNA
I6I52_RS16390	COG2369	cell adhesion
I6I52_RS16410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I52_RS16435	COG3328	transposase activity
I6I52_RS16480	COG1785	Belongs to the alkaline phosphatase family
I6I52_RS16535	COG1570	exodeoxyribonuclease VII activity
I6I52_RS16550	COG3328	transposase activity
I6I52_RS16560	COG0582	viral genome integration into host DNA
I6I52_RS16630	COG3328	transposase activity
I6I52_RS16635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I52_RS16695	COG3676	manually curated
I6I52_RS16700	COG0154	amidase activity
I6I52_RS16715	COG0431	NADPH-dependent FMN reductase
I6I52_RS16735	COG1192	Involved in chromosome partitioning
I6I52_RS16740	COG1475	DNA binding
I6I52_RS16785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I52_RS16790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I52_RS16820	COG4680	protein conserved in bacteria
I6I52_RS16835	COG1063	alcohol dehydrogenase
I6I52_RS16855	COG2323	membrane
I6I52_RS16900	COG2223	nitrite transmembrane transporter activity
I6I52_RS16905	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I52_RS16910	COG1877	trehalose-phosphatase activity