locus-tag	class	description
I6I53_RS00050	COG0556	nucleotide-excision repair
I6I53_RS00105	COG0582	viral genome integration into host DNA
I6I53_RS00110	COG2369	cell adhesion
I6I53_RS00130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I53_RS00135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I53_RS00165	COG2184	nucleotidyltransferase activity
I6I53_RS00190	COG0697	spore germination
I6I53_RS00230	COG1475	DNA binding
I6I53_RS00235	COG1192	Involved in chromosome partitioning
I6I53_RS00270	COG0583	DNA-binding transcription factor activity
I6I53_RS00280	COG0371	Dehydrogenase
I6I53_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS00290	COG0477	Major facilitator Superfamily
I6I53_RS00355	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I53_RS00380	COG2132	Multicopper oxidase
I6I53_RS00395	COG2205	protein histidine kinase activity
I6I53_RS00400	COG2217	Heavy metal translocating P-type atpase
I6I53_RS00440	COG0640	Transcriptional regulator
I6I53_RS00450	COG0798	PFAM Bile acid sodium symporter
I6I53_RS00455	COG0431	NADPH-dependent FMN reductase
I6I53_RS00465	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6I53_RS00475	COG0604	alcohol dehydrogenase
I6I53_RS00480	COG1309	transcriptional regulator
I6I53_RS00535	COG0583	DNA-binding transcription factor activity
I6I53_RS00555	COG2233	PERMEase
I6I53_RS00565	COG0583	DNA-binding transcription factor activity
I6I53_RS00595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I53_RS00600	COG2828	Protein conserved in bacteria
I6I53_RS00605	COG1113	amino acid transport
I6I53_RS00625	COG0658	competence protein
I6I53_RS00625	COG2333	competence protein COMEC
I6I53_RS00630	COG1136	(ABC) transporter
I6I53_RS00650	COG1671	Belongs to the UPF0178 family
I6I53_RS00660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I53_RS00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_RS00695	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS00705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I53_RS00720	COG3384	dioxygenase
I6I53_RS00730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I53_RS00735	COG2878	Part of a membrane complex involved in electron transport
I6I53_RS00740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I53_RS00750	COG0563	adenylate kinase activity
I6I53_RS00765	COG0768	penicillin binding
I6I53_RS00770	COG0742	ribosomal rna small subunit methyltransferase
I6I53_RS00795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I53_RS00800	COG0830	nickel cation binding
I6I53_RS00805	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I53_RS00810	COG0804	urea catabolic process
I6I53_RS00820	COG0832	Belongs to the urease beta subunit family
I6I53_RS00825	COG0831	urea catabolic process
I6I53_RS00830	COG0829	nickel cation binding
I6I53_RS00845	COG3015	lipoprotein NlpE involved in copper resistance
I6I53_RS00855	COG3676	manually curated
I6I53_RS00870	COG1253	flavin adenine dinucleotide binding
I6I53_RS00880	COG1116	anion transmembrane transporter activity
I6I53_RS00900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I53_RS00910	COG0864	Transcriptional regulator
I6I53_RS00915	COG0439	Biotin carboxylase
I6I53_RS00940	COG2851	Citrate transporter
I6I53_RS00950	COG0175	sulfate reduction
I6I53_RS00955	COG1492	cobalamin metabolic process
I6I53_RS00980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I53_RS00990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I53_RS01060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I53_RS01070	COG0193	aminoacyl-tRNA hydrolase activity
I6I53_RS01100	COG1054	Belongs to the UPF0176 family
I6I53_RS01110	COG0586	Pfam SNARE associated Golgi protein
I6I53_RS01115	COG0500	methyltransferase
I6I53_RS01140	COG0321	lipoyl(octanoyl) transferase activity
I6I53_RS01155	COG0531	amino acid
I6I53_RS01160	COG2321	neutral zinc metallopeptidase
I6I53_RS01165	COG2354	Protein conserved in bacteria
I6I53_RS01195	COG1215	transferase activity, transferring glycosyl groups
I6I53_RS01200	COG0726	polysaccharide deacetylase
I6I53_RS01200	COG1649	PFAM Uncharacterised BCR, COG1649
I6I53_RS01215	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I53_RS01220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I53_RS01235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I53_RS01240	COG1053	succinate dehydrogenase
I6I53_RS01245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I53_RS01250	COG2009	succinate dehydrogenase
I6I53_RS01260	COG1607	acyl-coa hydrolase
I6I53_RS01270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I53_RS01275	COG1309	transcriptional regulator
I6I53_RS01280	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_RS01285	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I53_RS01310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I53_RS01315	COG1120	ATPase activity
I6I53_RS01330	COG0028	Belongs to the TPP enzyme family
I6I53_RS01335	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_RS01340	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I53_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS01360	COG2271	Major facilitator Superfamily
I6I53_RS01365	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I53_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS01395	COG1414	Transcriptional regulator
I6I53_RS01415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I53_RS01435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I53_RS01445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I53_RS01455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I53_RS01465	COG0084	hydrolase, TatD family'
I6I53_RS01480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I53_RS01495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I53_RS01505	COG0028	Belongs to the TPP enzyme family
I6I53_RS01530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_RS01535	COG1136	(ABC) transporter
I6I53_RS01535	COG0577	efflux transmembrane transporter activity
I6I53_RS01550	COG2223	nitrite transmembrane transporter activity
I6I53_RS01580	COG0583	DNA-binding transcription factor activity
I6I53_RS01585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I53_RS01590	COG0436	Aminotransferase
I6I53_RS01595	COG1301	dicarboxylic acid transport
I6I53_RS01600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I53_RS01610	COG2223	nitrite transmembrane transporter activity
I6I53_RS01615	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I53_RS01620	COG1877	trehalose-phosphatase activity
I6I53_RS01655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I53_RS01660	COG2814	Major facilitator Superfamily
I6I53_RS01665	COG1566	PFAM secretion protein HlyD family protein
I6I53_RS01670	COG2050	protein possibly involved in aromatic compounds catabolism
I6I53_RS01695	COG0420	3'-5' exonuclease activity
I6I53_RS01710	COG1968	undecaprenyl-diphosphatase activity
I6I53_RS01730	COG0735	belongs to the Fur family
I6I53_RS01735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I53_RS01740	COG2914	Belongs to the UPF0125 (RnfH) family
I6I53_RS01755	COG0121	glutamine amidotransferase
I6I53_RS01765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I53_RS01770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I53_RS01775	COG0756	dUTP diphosphatase activity
I6I53_RS01785	COG2885	chlorophyll binding
I6I53_RS01790	COG0204	Acyl-transferase
I6I53_RS01800	COG0850	regulation of cytokinetic process
I6I53_RS01805	COG2894	cell division
I6I53_RS01810	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I53_RS01820	COG1280	lysine exporter protein (LysE YggA)
I6I53_RS01835	COG0531	amino acid
I6I53_RS01835	COG1674	ftsk spoiiie
I6I53_RS01840	COG0492	ferredoxin-NADP+ reductase activity
I6I53_RS01845	COG0500	methyltransferase
I6I53_RS01850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I53_RS01855	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I53_RS01860	COG0456	acetyltransferase
I6I53_RS01870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I53_RS01875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I53_RS01900	COG1981	membrane
I6I53_RS01920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I53_RS01920	COG0352	thiamine-phosphate diphosphorylase activity
I6I53_RS01920	COG0351	phosphomethylpyrimidine kinase
I6I53_RS01925	COG1733	regulation of RNA biosynthetic process
I6I53_RS01935	COG1652	LysM domain
I6I53_RS01945	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS01960	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I53_RS01965	COG3101	peptidyl-lysine hydroxylation
I6I53_RS01970	COG0009	L-threonylcarbamoyladenylate synthase
I6I53_RS01980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I53_RS01985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I53_RS02015	COG4106	trans-aconitate 2-methyltransferase activity
I6I53_RS02025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I53_RS02025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I53_RS02040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I53_RS02055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I53_RS02065	COG1196	nuclear chromosome segregation
I6I53_RS02075	COG0730	response to heat
I6I53_RS02080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I53_RS02080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I53_RS02090	COG3545	Serine hydrolase
I6I53_RS02100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I53_RS02110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I53_RS02125	COG3422	double-strand break repair
I6I53_RS02130	COG0494	nUDIX hydrolase
I6I53_RS02135	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I53_RS02150	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I53_RS02155	COG1115	amino acid carrier protein
I6I53_RS02160	COG0786	glutamate:sodium symporter activity
I6I53_RS02175	COG2814	Major facilitator Superfamily
I6I53_RS02180	COG1289	transmembrane transporter activity
I6I53_RS02190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I53_RS02235	COG1376	ErfK ybiS ycfS ynhG family protein
I6I53_RS02240	COG2832	Protein of unknown function (DUF454)
I6I53_RS02250	COG5510	response to toxic substance
I6I53_RS02255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I53_RS02270	COG0183	Belongs to the thiolase family
I6I53_RS02300	COG1956	GAF domain-containing protein
I6I53_RS02305	COG1607	acyl-coa hydrolase
I6I53_RS02365	COG2199	diguanylate cyclase activity
I6I53_RS02370	COG2885	chlorophyll binding
I6I53_RS02395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I53_RS02400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I53_RS02410	COG0653	protein targeting
I6I53_RS02415	COG0450	alkyl hydroperoxide reductase
I6I53_RS02435	COG0285	dihydrofolate synthase activity
I6I53_RS02440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I53_RS02480	COG4206	TonB-dependent receptor
I6I53_RS02485	COG2096	Adenosyltransferase
I6I53_RS02505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I53_RS02525	COG2205	protein histidine kinase activity
I6I53_RS02525	COG0784	Response regulator, receiver
I6I53_RS02525	COG5002	protein histidine kinase activity
I6I53_RS02540	COG3622	Belongs to the hyi family
I6I53_RS02565	COG0740	serine-type endopeptidase activity
I6I53_RS02570	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I53_RS02575	COG4774	siderophore transport
I6I53_RS02580	COG3128	pkhd-type hydroxylase
I6I53_RS02585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I53_RS02590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I53_RS02595	COG2813	Specifically methylates the guanine in position
I6I53_RS02595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I53_RS02605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I53_RS02640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I53_RS02655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I53_RS02695	COG0788	formyltetrahydrofolate deformylase activity
I6I53_RS02700	COG1309	transcriptional regulator
I6I53_RS02720	COG4651	solute:proton antiporter activity
I6I53_RS02720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I53_RS02740	COG0210	DNA helicase
I6I53_RS02750	COG5001	Diguanylate cyclase
I6I53_RS02750	COG2203	Gaf domain
I6I53_RS02750	COG3706	GGDEF domain
I6I53_RS02750	COG4251	negative regulation of phosphorylation
I6I53_RS02775	COG2900	Belongs to the SlyX family
I6I53_RS02780	COG0488	(ABC) transporter
I6I53_RS02790	COG0405	Gamma-glutamyltransferase
I6I53_RS02795	COG1560	Kdo2-lipid A biosynthetic process
I6I53_RS02800	COG0438	transferase activity, transferring glycosyl groups
I6I53_RS02805	COG1301	dicarboxylic acid transport
I6I53_RS02840	COG0101	tRNA pseudouridine synthase activity
I6I53_RS02855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I53_RS02865	COG0473	3-isopropylmalate dehydrogenase activity
I6I53_RS02880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I53_RS02890	COG3676	manually curated
I6I53_RS02895	COG0583	DNA-binding transcription factor activity
I6I53_RS02910	COG0494	nUDIX hydrolase
I6I53_RS02920	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS02930	COG0753	catalase activity
I6I53_RS02935	COG4993	Dehydrogenase
I6I53_RS02950	COG0583	DNA-binding transcription factor activity
I6I53_RS02970	COG1530	ribonuclease E activity
I6I53_RS02975	COG0318	PFAM AMP-dependent synthetase and ligase
I6I53_RS02990	COG0450	alkyl hydroperoxide reductase
I6I53_RS02995	COG0583	DNA-binding transcription factor activity
I6I53_RS03000	COG4221	oxidoreductase activity
I6I53_RS03015	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS03030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I53_RS03040	COG0534	Mate efflux family protein
I6I53_RS03055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I53_RS03060	COG0254	rRNA binding
I6I53_RS03070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_RS03090	COG0493	'glutamate synthase
I6I53_RS03090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I53_RS03100	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I53_RS03110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I53_RS03115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I53_RS03125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I53_RS03135	COG0644	oxidoreductase
I6I53_RS03135	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I53_RS03150	COG0425	Belongs to the sulfur carrier protein TusA family
I6I53_RS03155	COG4535	Mg2 and Co2 transporter CorC
I6I53_RS03160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I53_RS03165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I53_RS03170	COG3676	manually curated
I6I53_RS03190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I53_RS03200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I53_RS03205	COG0484	heat shock protein binding
I6I53_RS03220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I53_RS03225	COG0598	Magnesium transport protein CorA
I6I53_RS03230	COG2841	Protein conserved in bacteria
I6I53_RS03235	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I53_RS03240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I53_RS03245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I53_RS03250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I53_RS03255	COG1074	ATP-dependent DNA helicase activity
I6I53_RS03260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I53_RS03285	COG2226	methyltransferase
I6I53_RS03295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I53_RS03305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I53_RS03320	COG2111	Na H antiporter
I6I53_RS03320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I53_RS03325	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I53_RS03330	COG0651	ATP synthesis coupled electron transport
I6I53_RS03335	COG1863	multisubunit Na H antiporter MnhE subunit
I6I53_RS03340	COG2212	antiporter activity
I6I53_RS03345	COG1320	monovalent cation:proton antiporter activity
I6I53_RS03360	COG0195	Participates in both transcription termination and antitermination
I6I53_RS03365	COG0779	Required for maturation of 30S ribosomal subunits
I6I53_RS03390	COG0149	triose-phosphate isomerase activity
I6I53_RS03410	COG0237	dephospho-CoA kinase activity
I6I53_RS03420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I53_RS03425	COG3123	guanosine phosphorylase activity
I6I53_RS03430	COG0497	DNA recombination
I6I53_RS03435	COG1678	Uncharacterized ACR, COG1678
I6I53_RS03440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I53_RS03455	COG1289	transmembrane transporter activity
I6I53_RS03465	COG1132	(ABC) transporter
I6I53_RS03475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I53_RS03475	COG2169	Transcriptional regulator
I6I53_RS03480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I53_RS03490	COG0322	excinuclease ABC activity
I6I53_RS03510	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I53_RS03510	COG1024	Enoyl-CoA hydratase
I6I53_RS03520	COG3177	Filamentation induced by cAMP protein fic
I6I53_RS03525	COG3307	-O-antigen
I6I53_RS03535	COG3307	-O-antigen
I6I53_RS03540	COG4969	Belongs to the N-Me-Phe pilin family
I6I53_RS03615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I53_RS03620	COG1704	LemA family
I6I53_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS03635	COG0477	Major facilitator Superfamily
I6I53_RS03640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I53_RS03645	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS03650	COG0583	DNA-binding transcription factor activity
I6I53_RS03655	COG0493	'glutamate synthase
I6I53_RS03660	COG0067	glutamate synthase
I6I53_RS03660	COG0069	glutamate synthase activity
I6I53_RS03660	COG0070	glutamate synthase
I6I53_RS03670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I53_RS03675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I53_RS03710	COG2226	methyltransferase
I6I53_RS03715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I53_RS03720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I53_RS03725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I53_RS03740	COG0275	rRNA processing
I6I53_RS03755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I53_RS03805	COG0488	(ABC) transporter
I6I53_RS03810	COG0028	Belongs to the TPP enzyme family
I6I53_RS03820	COG4221	oxidoreductase activity
I6I53_RS03850	COG0427	acetyl-CoA hydrolase
I6I53_RS03855	COG0456	acetyltransferase
I6I53_RS03885	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I53_RS03890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I53_RS03900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I53_RS03910	COG1132	(ABC) transporter
I6I53_RS03915	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I53_RS03915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I53_RS03920	COG0531	amino acid
I6I53_RS03940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I53_RS03980	COG3158	transport of potassium into the cell
I6I53_RS03995	COG2814	Major facilitator Superfamily
I6I53_RS04005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I53_RS04040	COG3706	GGDEF domain
I6I53_RS04060	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6I53_RS04070	COG1335	isochorismatase
I6I53_RS04105	COG1538	Outer membrane efflux protein
I6I53_RS04130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I53_RS04135	COG1113	amino acid transport
I6I53_RS04140	COG0251	oxidation-reduction process
I6I53_RS04150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I53_RS04170	COG0277	FAD linked oxidase domain protein
I6I53_RS04175	COG1304	FMN binding
I6I53_RS04180	COG2186	Transcriptional regulator
I6I53_RS04185	COG1620	l-lactate permease
I6I53_RS04190	COG0583	DNA-binding transcription factor activity
I6I53_RS04195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I53_RS04210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I53_RS04225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I53_RS04275	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I53_RS04280	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I53_RS04285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I53_RS04290	COG1596	polysaccharide export
I6I53_RS04320	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I53_RS04340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I53_RS04370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I53_RS04375	COG0546	phosphoglycolate phosphatase activity
I6I53_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS04400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I53_RS04400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I53_RS04405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_RS04410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_RS04415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_RS04420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_RS04425	COG1116	anion transmembrane transporter activity
I6I53_RS04435	COG2233	PERMEase
I6I53_RS04440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_RS04445	COG0251	oxidation-reduction process
I6I53_RS04450	COG1335	isochorismatase
I6I53_RS04455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_RS04460	COG1309	transcriptional regulator
I6I53_RS04465	COG0596	Alpha beta hydrolase
I6I53_RS04480	COG0196	riboflavin kinase activity
I6I53_RS04485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I53_RS04490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I53_RS04495	COG1047	Peptidyl-prolyl cis-trans
I6I53_RS04570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I53_RS04575	COG0657	acetylesterase activity
I6I53_RS04590	COG0583	DNA-binding transcription factor activity
I6I53_RS04595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I53_RS04600	COG0443	Heat shock 70 kDa protein
I6I53_RS04615	COG2951	lytic endotransglycosylase activity
I6I53_RS04620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I53_RS04635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I53_RS04660	COG0861	Integral membrane protein TerC family
I6I53_RS04670	COG0402	S-adenosylhomocysteine deaminase activity
I6I53_RS04685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I53_RS04695	COG0706	membrane insertase activity
I6I53_RS04700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I53_RS04705	COG0594	ribonuclease P activity
I6I53_RS04715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I53_RS04720	COG0592	DNA-directed DNA polymerase activity
I6I53_RS04725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I53_RS04730	COG0187	DNA topoisomerase II activity
I6I53_RS04740	COG0488	(ABC) transporter
I6I53_RS04760	COG0316	Belongs to the HesB IscA family
I6I53_RS04765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I53_RS04770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I53_RS04805	COG0693	protein deglycase activity
I6I53_RS04820	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_RS04825	COG0733	neurotransmitter:sodium symporter activity
I6I53_RS04835	COG0428	transporter
I6I53_RS04840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I53_RS04845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I53_RS04860	COG1252	NADH dehydrogenase
I6I53_RS04865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I53_RS04880	COG2233	PERMEase
I6I53_RS04885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I53_RS04890	COG1309	transcriptional regulator
I6I53_RS04895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_RS04910	COG0484	heat shock protein binding
I6I53_RS04915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I53_RS04925	COG2814	Major facilitator Superfamily
I6I53_RS04930	COG0583	DNA-binding transcription factor activity
I6I53_RS04940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I53_RS04945	COG1064	alcohol dehydrogenase
I6I53_RS04950	COG2818	Glycosylase
I6I53_RS04980	COG5487	UPF0391 membrane protein
I6I53_RS04985	COG2983	Belongs to the UPF0260 family
I6I53_RS05000	COG2133	pyrroloquinoline quinone binding
I6I53_RS05010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I53_RS05015	COG2116	formate transmembrane transporter activity
I6I53_RS05020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I53_RS05030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I53_RS05035	COG1335	isochorismatase
I6I53_RS05040	COG0385	Bile acid
I6I53_RS05045	COG2388	GCN5-related N-acetyl-transferase
I6I53_RS05080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I53_RS05090	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I53_RS05095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I53_RS05100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I53_RS05105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I53_RS05120	COG3830	Belongs to the UPF0237 family
I6I53_RS05120	COG0560	Phosphoserine phosphatase
I6I53_RS05140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I53_RS05150	COG0688	phosphatidylethanolamine metabolic process
I6I53_RS05160	COG0300	oxidoreductase activity
I6I53_RS05190	COG0534	Mate efflux family protein
I6I53_RS05195	COG0436	Aminotransferase
I6I53_RS05200	COG2733	membrane
I6I53_RS05215	COG2918	glutathione biosynthetic process
I6I53_RS05230	COG3150	esterase
I6I53_RS05255	COG4266	Belongs to the allantoicase family
I6I53_RS05260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_RS05270	COG1247	-acetyltransferase
I6I53_RS05315	COG0625	glutathione transferase activity
I6I53_RS05320	COG3706	GGDEF domain
I6I53_RS05335	COG1393	Belongs to the ArsC family
I6I53_RS05340	COG0708	Exodeoxyribonuclease III
I6I53_RS05360	COG0189	ligase activity
I6I53_RS05365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I53_RS05375	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I53_RS05380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I53_RS05390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I53_RS05425	COG2119	membrane
I6I53_RS05430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_RS05430	COG0426	domain, Protein
I6I53_RS05455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I53_RS05475	COG1902	pentaerythritol trinitrate reductase activity
I6I53_RS05490	COG0668	transmembrane transport
I6I53_RS05500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I53_RS05530	COG0004	ammonium transporteR
I6I53_RS05545	COG0784	Response regulator, receiver
I6I53_RS05545	COG2205	protein histidine kinase activity
I6I53_RS05550	COG3162	membrane
I6I53_RS05555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I53_RS05570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I53_RS05590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_RS05615	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS05630	COG2175	clavaminate synthase activity
I6I53_RS05645	COG0519	Catalyzes the synthesis of GMP from XMP
I6I53_RS05645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I53_RS05650	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I53_RS05655	COG2259	Doxx family
I6I53_RS05660	COG0586	Pfam SNARE associated Golgi protein
I6I53_RS05675	COG1192	Involved in chromosome partitioning
I6I53_RS05740	COG0018	arginyl-trna synthetase
I6I53_RS05750	COG0281	malic enzyme
I6I53_RS05755	COG1280	lysine exporter protein (LysE YggA)
I6I53_RS05760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I53_RS05765	COG1121	(ABC) transporter
I6I53_RS05785	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I53_RS05815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I53_RS05820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I53_RS05845	COG0386	Belongs to the glutathione peroxidase family
I6I53_RS05855	COG2814	Major facilitator Superfamily
I6I53_RS05860	COG1309	transcriptional regulator
I6I53_RS05865	COG0697	spore germination
I6I53_RS05905	COG3845	ABC transporter
I6I53_RS05910	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I53_RS05915	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I53_RS05920	COG0009	L-threonylcarbamoyladenylate synthase
I6I53_RS05925	COG0758	DNA mediated transformation
I6I53_RS05930	COG1652	LysM domain
I6I53_RS05960	COG1309	transcriptional regulator
I6I53_RS06010	COG0477	Major facilitator Superfamily
I6I53_RS06015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I53_RS06035	COG1253	flavin adenine dinucleotide binding
I6I53_RS06045	COG2860	membrane
I6I53_RS06055	COG0477	Major facilitator Superfamily
I6I53_RS06065	COG0318	PFAM AMP-dependent synthetase and ligase
I6I53_RS06080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I53_RS06105	COG0347	Belongs to the P(II) protein family
I6I53_RS06110	COG0004	ammonium transporteR
I6I53_RS06115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I53_RS06120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I53_RS06120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I53_RS06155	COG0795	lipopolysaccharide-transporting ATPase activity
I6I53_RS06160	COG0795	lipopolysaccharide-transporting ATPase activity
I6I53_RS06165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I53_RS06170	COG0793	Belongs to the peptidase S41A family
I6I53_RS06185	COG2197	response regulator
I6I53_RS06195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I53_RS06205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I53_RS06210	COG4974	Belongs to the 'phage' integrase family
I6I53_RS06230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I53_RS06235	COG0772	Belongs to the SEDS family
I6I53_RS06240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I53_RS06245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I53_RS06250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I53_RS06255	COG0494	nUDIX hydrolase
I6I53_RS06285	COG3275	phosphorelay sensor kinase activity
I6I53_RS06295	COG0181	hydroxymethylbilane synthase activity
I6I53_RS06340	COG1716	ATPase activity
I6I53_RS06375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I53_RS06395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I53_RS06400	COG0081	regulation of translation
I6I53_RS06415	COG0085	RNA polymerase activity
I6I53_RS06420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I53_RS06450	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS06465	COG0326	Molecular chaperone. Has ATPase activity
I6I53_RS06495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I53_RS06520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I53_RS06525	COG1758	RNA polymerase activity
I6I53_RS06530	COG0194	GDP metabolic process
I6I53_RS06575	COG0228	four-way junction DNA binding
I6I53_RS06580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I53_RS06590	COG0335	large ribosomal subunit rRNA binding
I6I53_RS06595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6I53_RS06600	COG5380	lipid catabolic process
I6I53_RS06605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I53_RS06625	COG5006	permease, DMT superfamily
I6I53_RS06630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I53_RS06635	COG0277	FAD linked oxidase domain protein
I6I53_RS06650	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I53_RS06655	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I53_RS06665	COG2814	Major facilitator Superfamily
I6I53_RS06670	COG1289	transmembrane transporter activity
I6I53_RS06690	COG0628	permease
I6I53_RS06695	COG1192	Involved in chromosome partitioning
I6I53_RS06740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I53_RS06755	COG0583	DNA-binding transcription factor activity
I6I53_RS06780	COG0752	glycyl-tRNA synthetase alpha subunit
I6I53_RS06795	COG0517	IMP dehydrogenase activity
I6I53_RS06800	COG1983	PspC domain protein
I6I53_RS06810	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS06820	COG2885	chlorophyll binding
I6I53_RS06830	COG0408	coproporphyrinogen oxidase activity
I6I53_RS06835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I53_RS06840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I53_RS06855	COG0513	Belongs to the DEAD box helicase family
I6I53_RS06860	COG1127	ABC transporter
I6I53_RS06865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I53_RS06885	COG0598	Magnesium transport protein CorA
I6I53_RS06895	COG0494	nUDIX hydrolase
I6I53_RS06900	COG1040	competence protein
I6I53_RS06905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I53_RS06920	COG2937	Belongs to the GPAT DAPAT family
I6I53_RS06925	COG1946	Acyl-CoA thioesterase
I6I53_RS06930	COG1301	dicarboxylic acid transport
I6I53_RS06945	COG1959	2 iron, 2 sulfur cluster binding
I6I53_RS06950	COG1017	nitric oxide dioxygenase activity
I6I53_RS06950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I53_RS06955	COG0433	COG0433 Predicted ATPase
I6I53_RS06970	COG0051	transcription antitermination factor activity, RNA binding
I6I53_RS06975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I53_RS06980	COG0088	Forms part of the polypeptide exit tunnel
I6I53_RS06995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I53_RS07000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I53_RS07010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I53_RS07020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I53_RS07025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I53_RS07030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I53_RS07035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I53_RS07045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I53_RS07050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I53_RS07060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I53_RS07085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I53_RS07095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I53_RS07100	COG0202	RNA polymerase activity
I6I53_RS07105	COG0203	ribosomal protein L17
I6I53_RS07110	COG2072	flavoprotein involved in K transport
I6I53_RS07115	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS07120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I53_RS07150	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I53_RS07155	COG0339	signal peptide processing
I6I53_RS07165	COG0557	exoribonuclease II activity
I6I53_RS07190	COG5002	protein histidine kinase activity
I6I53_RS07210	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I53_RS07220	COG2814	Major facilitator Superfamily
I6I53_RS07225	COG0583	DNA-binding transcription factor activity
I6I53_RS07240	COG1295	ribonuclease BN
I6I53_RS07275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I53_RS07280	COG1702	phosphate starvation-inducible protein PhoH
I6I53_RS07285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I53_RS07290	COG1196	nuclear chromosome segregation
I6I53_RS07290	COG0741	lytic transglycosylase activity
I6I53_RS07290	COG0739	heme binding
I6I53_RS07300	COG0039	L-malate dehydrogenase activity
I6I53_RS07320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I53_RS07325	COG1183	phosphatidylcholine synthase activity
I6I53_RS07385	COG2969	positive regulation of protein catabolic process
I6I53_RS07390	COG0625	glutathione transferase activity
I6I53_RS07395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I53_RS07405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I53_RS07410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I53_RS07415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I53_RS07435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I53_RS07450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I53_RS07455	COG1408	metallophosphoesterase
I6I53_RS07460	COG0477	Major facilitator Superfamily
I6I53_RS07465	COG1272	protein, Hemolysin III
I6I53_RS07475	COG2153	protein acetylation
I6I53_RS07485	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I53_RS07500	COG0183	Belongs to the thiolase family
I6I53_RS07515	COG2207	Transcriptional regulator
I6I53_RS07535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_RS07545	COG0442	prolyl-tRNA aminoacylation
I6I53_RS07580	COG0840	transmembrane signaling receptor activity
I6I53_RS07585	COG0643	Histidine kinase
I6I53_RS07585	COG2198	Histidine kinase
I6I53_RS07600	COG1690	Belongs to the RtcB family
I6I53_RS07605	COG0833	amino acid
I6I53_RS07610	COG2813	Specifically methylates the guanine in position
I6I53_RS07615	COG2233	PERMEase
I6I53_RS07620	COG1217	gtp-binding protein TYPA
I6I53_RS07625	COG1970	mechanosensitive ion channel activity
I6I53_RS07640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I53_RS07645	COG2094	Belongs to the DNA glycosylase MPG family
I6I53_RS07650	COG4772	TonB-dependent receptor
I6I53_RS07655	COG1902	pentaerythritol trinitrate reductase activity
I6I53_RS07690	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I53_RS07735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I53_RS07740	COG0154	amidase activity
I6I53_RS07745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I53_RS07750	COG1077	Cell shape determining protein MreB Mrl
I6I53_RS07755	COG1792	Involved in formation and maintenance of cell shape
I6I53_RS07765	COG0424	maF-like protein
I6I53_RS07770	COG1530	ribonuclease E activity
I6I53_RS07780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I53_RS07790	COG0560	Phosphoserine phosphatase
I6I53_RS07805	COG2350	Protein conserved in bacteria
I6I53_RS07820	COG0583	DNA-binding transcription factor activity
I6I53_RS07825	COG0667	Aldo Keto reductase
I6I53_RS07830	COG3781	membrane
I6I53_RS07835	COG2003	Belongs to the UPF0758 family
I6I53_RS07840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I53_RS07845	COG3783	Cytochrome b(562)
I6I53_RS07855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I53_RS07865	COG1162	GTPase activity
I6I53_RS07870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I53_RS07875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I53_RS07875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I53_RS07880	COG2226	methyltransferase
I6I53_RS07885	COG1335	isochorismatase
I6I53_RS07890	COG0280	phosphate acetyltransferase
I6I53_RS07890	COG0857	belongs to the CobB CobQ family
I6I53_RS07895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I53_RS07900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I53_RS07905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I53_RS07920	COG0793	Belongs to the peptidase S41A family
I6I53_RS07940	COG0105	UTP biosynthetic process
I6I53_RS07955	COG1426	Protein conserved in bacteria
I6I53_RS08000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I53_RS08010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I53_RS08025	COG2986	histidine ammonia-lyase
I6I53_RS08045	COG0644	oxidoreductase
I6I53_RS08055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I53_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS08070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I53_RS08100	COG1862	Preprotein translocase
I6I53_RS08110	COG1704	LemA family
I6I53_RS08120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I53_RS08135	COG4453	Protein conserved in bacteria
I6I53_RS08210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I53_RS08230	COG2814	Major facilitator Superfamily
I6I53_RS08240	COG0789	Transcriptional regulator
I6I53_RS08245	COG0697	spore germination
I6I53_RS08275	COG3706	GGDEF domain
I6I53_RS08280	COG2205	protein histidine kinase activity
I6I53_RS08285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I53_RS08300	COG0726	polysaccharide deacetylase
I6I53_RS08305	COG0438	transferase activity, transferring glycosyl groups
I6I53_RS08315	COG0438	transferase activity, transferring glycosyl groups
I6I53_RS08320	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS08335	COG1442	glycosyl transferase family 8
I6I53_RS08350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I53_RS08400	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS08405	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS08415	COG2205	protein histidine kinase activity
I6I53_RS08420	COG0745	RESPONSE REGULATOR receiver
I6I53_RS08425	COG2315	Protein conserved in bacteria
I6I53_RS08440	COG3956	TIGRFAM MazG family protein
I6I53_RS08445	COG1555	photosystem II stabilization
I6I53_RS08450	COG0617	tRNA 3'-terminal CCA addition
I6I53_RS08455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I53_RS08465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I53_RS08470	COG1660	Displays ATPase and GTPase activities
I6I53_RS08475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I53_RS08480	COG3028	Belongs to the UPF0307 family
I6I53_RS08485	COG0318	PFAM AMP-dependent synthetase and ligase
I6I53_RS08490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I53_RS08505	COG0625	glutathione transferase activity
I6I53_RS08510	COG1238	metal cluster binding
I6I53_RS08525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I53_RS08550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I53_RS08555	COG0072	phenylalanine-tRNA ligase activity
I6I53_RS08560	COG0776	regulation of translation
I6I53_RS08580	COG0248	Ppx GppA phosphatase
I6I53_RS08590	COG0037	tRNA processing
I6I53_RS08630	COG1846	Transcriptional regulator
I6I53_RS08635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I53_RS08695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I53_RS08700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I53_RS08710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I53_RS08765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I53_RS08770	COG1214	PFAM Peptidase M22, glycoprotease
I6I53_RS08775	COG1968	undecaprenyl-diphosphatase activity
I6I53_RS08780	COG0742	ribosomal rna small subunit methyltransferase
I6I53_RS08800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I53_RS08815	COG2132	Multicopper oxidase
I6I53_RS08840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I53_RS08940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I53_RS08955	COG0745	RESPONSE REGULATOR receiver
I6I53_RS08960	COG2205	protein histidine kinase activity
I6I53_RS08970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_RS08975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_RS08980	COG0649	NAD binding
I6I53_RS08980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_RS08990	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I53_RS09005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_RS09015	COG0713	ATP synthesis coupled electron transport
I6I53_RS09020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I53_RS09025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_RS09035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I53_RS09050	COG0583	DNA-binding transcription factor activity
I6I53_RS09070	COG0668	transmembrane transport
I6I53_RS09080	COG2081	HI0933 family
I6I53_RS09085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I53_RS09110	COG1280	lysine exporter protein (LysE YggA)
I6I53_RS09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I53_RS09160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I53_RS09160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I53_RS09170	COG0489	protein tyrosine kinase activity
I6I53_RS09175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I53_RS09190	COG0717	Belongs to the dCTP deaminase family
I6I53_RS09255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I53_RS09260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I53_RS09265	COG0628	permease
I6I53_RS09290	COG0583	DNA-binding transcription factor activity
I6I53_RS09295	COG0697	spore germination
I6I53_RS09335	COG4983	Phage plasmid primase, P4 family domain protein
I6I53_RS09345	COG4974	Belongs to the 'phage' integrase family
I6I53_RS09355	COG0583	DNA-binding transcription factor activity
I6I53_RS09360	COG0596	Alpha beta hydrolase
I6I53_RS09380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I53_RS09385	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I53_RS09390	COG2301	Belongs to the HpcH HpaI aldolase family
I6I53_RS09395	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS09405	COG0477	Major facilitator Superfamily
I6I53_RS09420	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I53_RS09425	COG4149	molybdate abc transporter
I6I53_RS09430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I53_RS09435	COG0183	Belongs to the thiolase family
I6I53_RS09440	COG2031	fatty acid transporter
I6I53_RS09455	COG0583	DNA-binding transcription factor activity
I6I53_RS09460	COG2610	gluconate transmembrane transporter activity
I6I53_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS09480	COG1595	DNA-templated transcription, initiation
I6I53_RS09490	COG1629	transport
I6I53_RS09505	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS09515	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_RS09520	COG1024	Enoyl-CoA hydratase
I6I53_RS09525	COG2814	Major facilitator Superfamily
I6I53_RS09535	COG1309	transcriptional regulator
I6I53_RS09550	COG2072	flavoprotein involved in K transport
I6I53_RS09555	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6I53_RS09560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I53_RS09580	COG1113	amino acid transport
I6I53_RS09595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I53_RS09600	COG2267	carboxylic ester hydrolase activity
I6I53_RS09605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I53_RS09630	COG2217	Heavy metal translocating P-type atpase
I6I53_RS09665	COG4383	Mu-like prophage protein gp29
I6I53_RS09675	COG5005	Phage virion morphogenesis
I6I53_RS09690	COG4397	Mu-like prophage major head subunit gpT
I6I53_RS09760	COG3299	homolog of phage Mu protein gp47
I6I53_RS09815	COG3079	Belongs to the UPF0149 family
I6I53_RS09820	COG0006	proline dipeptidase activity
I6I53_RS09825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_RS09830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_RS09845	COG3107	peptidoglycan biosynthetic process
I6I53_RS09850	COG0792	nuclease activity
I6I53_RS09875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I53_RS09880	COG0741	lytic transglycosylase activity
I6I53_RS09880	COG0741	lytic transglycosylase activity
I6I53_RS09880	COG1388	LysM domain
I6I53_RS09880	COG1388	LysM domain
I6I53_RS09885	COG4166	transmembrane transport
I6I53_RS09890	COG4174	ABC transporter (Permease)
I6I53_RS09895	COG4239	(ABC) transporter, permease
I6I53_RS09900	COG4172	Belongs to the ABC transporter superfamily
I6I53_RS09920	COG2351	hydroxyisourate hydrolase activity
I6I53_RS09930	COG1187	pseudouridine synthase activity
I6I53_RS09940	COG1823	symporter activity
I6I53_RS09945	COG0384	phenazine biosynthesis protein PhzF
I6I53_RS09950	COG0038	chloride channel
I6I53_RS09955	COG0612	Peptidase, M16
I6I53_RS10010	COG1522	sequence-specific DNA binding
I6I53_RS10030	COG1802	Transcriptional regulator
I6I53_RS10065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_RS10085	COG3676	manually curated
I6I53_RS10120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I53_RS10125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I53_RS10130	COG1045	serine acetyltransferase
I6I53_RS10145	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS10155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I53_RS10180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I53_RS10185	COG2239	Acts as a magnesium transporter
I6I53_RS10195	COG0501	Belongs to the peptidase M48B family
I6I53_RS10200	COG0739	heme binding
I6I53_RS10200	COG0741	lytic transglycosylase activity
I6I53_RS10200	COG1196	nuclear chromosome segregation
I6I53_RS10205	COG0037	tRNA processing
I6I53_RS10215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I53_RS10220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I53_RS10230	COG0583	DNA-binding transcription factor activity
I6I53_RS10240	COG0475	glutathione-regulated potassium exporter activity
I6I53_RS10240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I53_RS10275	COG1741	Belongs to the pirin family
I6I53_RS10285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I53_RS10290	COG3739	integral membrane protein
I6I53_RS10300	COG0586	Pfam SNARE associated Golgi protein
I6I53_RS10305	COG0302	gtp cyclohydrolase
I6I53_RS10315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I53_RS10320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I53_RS10320	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I53_RS10330	COG0134	indole-3-glycerol-phosphate synthase activity
I6I53_RS10335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I53_RS10340	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I53_RS10345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I53_RS10350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I53_RS10355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I53_RS10360	COG1067	ATP-dependent peptidase activity
I6I53_RS10375	COG0254	rRNA binding
I6I53_RS10380	COG0583	DNA-binding transcription factor activity
I6I53_RS10385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I53_RS10390	COG4208	sulfate ABC transporter
I6I53_RS10395	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I53_RS10405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I53_RS10410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I53_RS10415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I53_RS10420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I53_RS10430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I53_RS10435	COG0174	glutamine synthetase
I6I53_RS10445	COG0481	GTPase activity
I6I53_RS10450	COG0681	Belongs to the peptidase S26 family
I6I53_RS10460	COG0571	ribonuclease III activity
I6I53_RS10465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I53_RS10475	COG1381	Involved in DNA repair and RecF pathway recombination
I6I53_RS10480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I53_RS10500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I53_RS10505	COG1301	dicarboxylic acid transport
I6I53_RS10525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I53_RS10530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I53_RS10555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I53_RS10560	COG0826	peptidase U32
I6I53_RS10565	COG3384	dioxygenase
I6I53_RS10570	COG1335	isochorismatase
I6I53_RS10585	COG1720	tRNA m6t6A37 methyltransferase activity
I6I53_RS10590	COG3706	GGDEF domain
I6I53_RS10595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I53_RS10600	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I53_RS10610	COG0642	Histidine kinase
I6I53_RS10620	COG0494	nUDIX hydrolase
I6I53_RS10630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I53_RS10635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I53_RS10640	COG3139	Protein of unknown function (DUF1315)
I6I53_RS10645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I53_RS10650	COG1301	dicarboxylic acid transport
I6I53_RS10660	COG0659	secondary active sulfate transmembrane transporter activity
I6I53_RS10670	COG2252	PERMEase
I6I53_RS10675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I53_RS10690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I53_RS10705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I53_RS10720	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I53_RS10725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I53_RS10740	COG0667	Aldo Keto reductase
I6I53_RS10750	COG1765	OsmC-like protein
I6I53_RS10775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I53_RS10775	COG0116	Belongs to the methyltransferase superfamily
I6I53_RS10780	COG0540	Belongs to the ATCase OTCase family
I6I53_RS10790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I53_RS10795	COG1686	Belongs to the peptidase S11 family
I6I53_RS10810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I53_RS10820	COG0583	DNA-binding transcription factor activity
I6I53_RS10835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I53_RS10840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I53_RS10860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I53_RS10865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I53_RS10870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I53_RS10885	COG4716	Myosin-crossreactive antigen
I6I53_RS10895	COG3706	GGDEF domain
I6I53_RS10905	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS10910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I53_RS10930	COG0625	glutathione transferase activity
I6I53_RS10970	COG0513	Belongs to the DEAD box helicase family
I6I53_RS10980	COG0778	Nitroreductase
I6I53_RS11005	COG0167	dihydroorotate dehydrogenase activity
I6I53_RS11010	COG1286	toxin biosynthetic process
I6I53_RS11045	COG1610	YqeY-like protein
I6I53_RS11065	COG0537	adenosine 5'-monophosphoramidase activity
I6I53_RS11095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I53_RS11105	COG3100	YcgL domain-containing protein
I6I53_RS11115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I53_RS11130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I53_RS11135	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I53_RS11145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I53_RS11150	COG1845	cytochrome c oxidase, subunit III
I6I53_RS11155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I53_RS11160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I53_RS11175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I53_RS11180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_RS11190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I53_RS11195	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I53_RS11210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I53_RS11215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_RS11250	COG3042	response to heat
I6I53_RS11255	COG3293	Transposase
I6I53_RS11260	COG1968	undecaprenyl-diphosphatase activity
I6I53_RS11285	COG2207	Transcriptional regulator
I6I53_RS11290	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I53_RS11300	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS11305	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS11330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I53_RS11340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I53_RS11345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I53_RS11350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I53_RS11355	COG2205	protein histidine kinase activity
I6I53_RS11360	COG0745	RESPONSE REGULATOR receiver
I6I53_RS11370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I53_RS11375	COG0477	Major facilitator Superfamily
I6I53_RS11380	COG0729	surface antigen
I6I53_RS11425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I53_RS11435	COG2204	response regulator
I6I53_RS11440	COG3852	Histidine kinase
I6I53_RS11450	COG0528	UMP kinase activity
I6I53_RS11455	COG0233	cytoplasmic translational termination
I6I53_RS11460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I53_RS11465	COG0575	Belongs to the CDS family
I6I53_RS11490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I53_RS11500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I53_RS11515	COG2137	regulation of response to DNA damage stimulus
I6I53_RS11525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I53_RS11530	COG1011	Hydrolase
I6I53_RS11535	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I53_RS11545	COG3594	Acyltransferase
I6I53_RS11550	COG0268	Binds directly to 16S ribosomal RNA
I6I53_RS11555	COG0702	epimerase
I6I53_RS11560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I53_RS11575	COG0069	glutamate synthase activity
I6I53_RS11580	COG2850	peptidyl-arginine hydroxylation
I6I53_RS11590	COG0424	maF-like protein
I6I53_RS11600	COG0126	phosphoglycerate kinase activity
I6I53_RS11610	COG0191	fructose-bisphosphate aldolase activity
I6I53_RS11615	COG0697	spore germination
I6I53_RS11620	COG0778	Nitroreductase
I6I53_RS11650	COG3698	Phosphodiester glycosidase
I6I53_RS11660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I53_RS11665	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I53_RS11670	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I53_RS11670	COG0506	proline dehydrogenase activity
I6I53_RS11670	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I53_RS11680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I53_RS11685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I53_RS11690	COG0477	Major facilitator Superfamily
I6I53_RS11695	COG2267	carboxylic ester hydrolase activity
I6I53_RS11705	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I53_RS11705	COG1902	pentaerythritol trinitrate reductase activity
I6I53_RS11725	COG0504	CTP synthase activity
I6I53_RS11735	COG0148	phosphopyruvate hydratase activity
I6I53_RS11745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I53_RS11750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I53_RS11760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_RS11760	COG1116	anion transmembrane transporter activity
I6I53_RS11765	COG0745	RESPONSE REGULATOR receiver
I6I53_RS11770	COG2223	nitrite transmembrane transporter activity
I6I53_RS11775	COG2146	nitrite reductase [NAD(P)H] activity
I6I53_RS11775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_RS11780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_RS11785	COG0243	molybdopterin cofactor binding
I6I53_RS11810	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I53_RS11810	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I53_RS11815	COG0303	'Molybdopterin
I6I53_RS11820	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I53_RS11830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I53_RS11835	COG0697	spore germination
I6I53_RS11855	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I53_RS11860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I53_RS11890	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS11930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I53_RS11940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I53_RS11945	COG0488	(ABC) transporter
I6I53_RS11950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I53_RS11955	COG0509	glycine decarboxylation via glycine cleavage system
I6I53_RS11970	COG1132	(ABC) transporter
I6I53_RS11975	COG0668	transmembrane transport
I6I53_RS11980	COG3122	Protein conserved in bacteria
I6I53_RS11995	COG0640	Transcriptional regulator
I6I53_RS12045	COG1595	DNA-templated transcription, initiation
I6I53_RS12060	COG1027	Aspartate ammonia-lyase
I6I53_RS12065	COG0583	DNA-binding transcription factor activity
I6I53_RS12070	COG1846	Transcriptional regulator
I6I53_RS12105	COG3676	manually curated
I6I53_RS12120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_RS12130	COG4993	Dehydrogenase
I6I53_RS12135	COG3659	wide pore channel activity
I6I53_RS12140	COG3420	alginic acid biosynthetic process
I6I53_RS12145	COG0710	3-dehydroquinate dehydratase activity
I6I53_RS12150	COG3485	protocatechuate 3,4-dioxygenase
I6I53_RS12155	COG3485	protocatechuate 3,4-dioxygenase
I6I53_RS12160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I53_RS12165	COG2271	Major facilitator Superfamily
I6I53_RS12170	COG0596	Alpha beta hydrolase
I6I53_RS12175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I53_RS12180	COG0183	Belongs to the thiolase family
I6I53_RS12185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I53_RS12190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I53_RS12195	COG1414	Transcriptional regulator
I6I53_RS12200	COG0477	Major facilitator Superfamily
I6I53_RS12205	COG0583	DNA-binding transcription factor activity
I6I53_RS12210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I53_RS12215	COG0235	Class ii aldolase
I6I53_RS12220	COG1024	Enoyl-CoA hydratase
I6I53_RS12225	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS12235	COG2814	Major facilitator Superfamily
I6I53_RS12245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I53_RS12255	COG2814	Major facilitator Superfamily
I6I53_RS12260	COG2814	Major facilitator Superfamily
I6I53_RS12265	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS12270	COG1024	Enoyl-CoA hydratase
I6I53_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS12280	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I53_RS12285	COG0183	Belongs to the thiolase family
I6I53_RS12300	COG2814	Major facilitator Superfamily
I6I53_RS12315	COG2814	Major facilitator Superfamily
I6I53_RS12320	COG0644	oxidoreductase
I6I53_RS12320	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I53_RS12370	COG0583	DNA-binding transcription factor activity
I6I53_RS12375	COG1380	Effector of murein hydrolase LrgA
I6I53_RS12380	COG1346	cytolysis
I6I53_RS12395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I53_RS12410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I53_RS12420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I53_RS12430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I53_RS12440	COG3676	manually curated
I6I53_RS12470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I53_RS12475	COG2814	Major facilitator Superfamily
I6I53_RS12480	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS12485	COG0583	DNA-binding transcription factor activity
I6I53_RS12495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I53_RS12500	COG0583	DNA-binding transcription factor activity
I6I53_RS12505	COG0024	Methionine aminopeptidase
I6I53_RS12570	COG2814	Major facilitator Superfamily
I6I53_RS12575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I53_RS12605	COG0822	iron-sulfur transferase activity
I6I53_RS12610	COG0316	Belongs to the HesB IscA family
I6I53_RS12640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I53_RS12660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I53_RS12665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I53_RS12670	COG1454	alcohol dehydrogenase
I6I53_RS12675	COG0824	Thioesterase
I6I53_RS12700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I53_RS12705	COG2030	dehydratase
I6I53_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS12740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I53_RS12750	COG3135	benzoate transporter
I6I53_RS12760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I53_RS12775	COG0589	response to stress
I6I53_RS12785	COG0308	aminopeptidase N
I6I53_RS12800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I53_RS12805	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I53_RS12815	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS12825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I53_RS12830	COG1454	alcohol dehydrogenase
I6I53_RS12850	COG0505	Belongs to the CarA family
I6I53_RS12860	COG2353	YceI-like domain
I6I53_RS12875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I53_RS12880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I53_RS12905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I53_RS12910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I53_RS12910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I53_RS12920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I53_RS12980	COG0776	regulation of translation
I6I53_RS13030	COG4373	Mu-like prophage FluMu protein gp28
I6I53_RS13045	COG4383	Mu-like prophage protein gp29
I6I53_RS13050	COG2369	cell adhesion
I6I53_RS13070	COG4397	Mu-like prophage major head subunit gpT
I6I53_RS13150	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6I53_RS13170	COG2193	ferroxidase activity
I6I53_RS13185	COG0217	transcriptional regulatory protein
I6I53_RS13200	COG1126	abc transporter atp-binding protein
I6I53_RS13205	COG0765	amino acid transport
I6I53_RS13210	COG0765	amino acid transport
I6I53_RS13235	COG0542	response to heat
I6I53_RS13240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I53_RS13250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I53_RS13265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I53_RS13270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I53_RS13275	COG0569	domain protein
I6I53_RS13280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I53_RS13295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I53_RS13305	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I53_RS13320	COG1294	oxidase, subunit
I6I53_RS13325	COG4890	Cyd operon protein YbgT
I6I53_RS13345	COG0552	protein localization to endoplasmic reticulum
I6I53_RS13380	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6I53_RS13385	COG0305	Participates in initiation and elongation during chromosome replication
I6I53_RS13390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I53_RS13405	COG1305	Transglutaminase-like
I6I53_RS13415	COG2308	Evidence 4 Homologs of previously reported genes of
I6I53_RS13425	COG0445	tRNA wobble uridine modification
I6I53_RS13450	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I53_RS13455	COG0138	bifunctional purine biosynthesis protein purh
I6I53_RS13465	COG1464	Belongs to the NlpA lipoprotein family
I6I53_RS13470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I53_RS13475	COG2011	ABC-type metal ion transport system permease component
I6I53_RS13515	COG0515	serine threonine protein kinase
I6I53_RS13515	COG2815	serine threonine protein kinase
I6I53_RS13550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I53_RS13575	COG0730	response to heat
I6I53_RS13580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I53_RS13590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I53_RS13605	COG1253	flavin adenine dinucleotide binding
I6I53_RS13625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I53_RS13645	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I53_RS13660	COG0776	regulation of translation
I6I53_RS13670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I53_RS13725	COG0084	hydrolase, TatD family'
I6I53_RS13745	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I53_RS13750	COG1132	(ABC) transporter
I6I53_RS13760	COG0811	peptide transport
I6I53_RS13765	COG1475	DNA binding
I6I53_RS13770	COG1192	Involved in chromosome partitioning
I6I53_RS13775	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I53_RS13780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I53_RS13790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I53_RS13795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I53_RS13800	COG1923	regulation of RNA biosynthetic process
I6I53_RS13805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I53_RS13810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I53_RS13815	COG0802	atpase or kinase
I6I53_RS13820	COG0564	pseudouridine synthase activity
I6I53_RS13850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I53_RS13860	COG2707	UPF0756 membrane protein
I6I53_RS13870	COG0583	DNA-binding transcription factor activity
I6I53_RS13880	COG2814	Major facilitator Superfamily
I6I53_RS13885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I53_RS13890	COG0471	metal ion transport
I6I53_RS13895	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_RS13920	COG1464	Belongs to the NlpA lipoprotein family
I6I53_RS13925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I53_RS13930	COG2011	ABC-type metal ion transport system permease component
I6I53_RS13935	COG0012	GTP binding
I6I53_RS13940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I53_RS13955	COG1942	4-Oxalocrotonate Tautomerase
I6I53_RS13960	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I53_RS13965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I53_RS13990	COG0386	Belongs to the glutathione peroxidase family
I6I53_RS13995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I53_RS14000	COG0436	Aminotransferase
I6I53_RS14075	COG3539	Fimbrial protein
I6I53_RS14085	COG3706	GGDEF domain
I6I53_RS14110	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I53_RS14115	COG0596	Alpha beta hydrolase
I6I53_RS14125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_RS14135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_RS14145	COG0714	Associated with various cellular activities
I6I53_RS14150	COG2879	small protein
I6I53_RS14155	COG1966	Carbon starvation protein
I6I53_RS14160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I53_RS14165	COG1509	lysine 2,3-aminomutase activity
I6I53_RS14180	COG4625	pathogenesis
I6I53_RS14190	COG0602	queuosine metabolic process
I6I53_RS14195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I53_RS14205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I53_RS14210	COG2353	YceI-like domain
I6I53_RS14215	COG1051	belongs to the nudix hydrolase family
I6I53_RS14215	COG1056	cytidyltransferase-related domain
I6I53_RS14220	COG1024	Enoyl-CoA hydratase
I6I53_RS14240	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I53_RS14240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I53_RS14250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I53_RS14250	COG3008	intermembrane lipid transfer
I6I53_RS14255	COG2995	paraquat-inducible protein a
I6I53_RS14280	COG0482	sulfurtransferase activity
I6I53_RS14285	COG2915	High frequency lysogenization protein hflD homolog
I6I53_RS14300	COG0616	signal peptide processing
I6I53_RS14305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I53_RS14315	COG0573	inorganic phosphate transmembrane transporter activity
I6I53_RS14320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I53_RS14325	COG0076	glutamate decarboxylase activity
I6I53_RS14330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I53_RS14355	COG1309	transcriptional regulator
I6I53_RS14360	COG0783	Belongs to the Dps family
I6I53_RS14370	COG0564	pseudouridine synthase activity
I6I53_RS14375	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6I53_RS14385	COG0352	thiamine-phosphate diphosphorylase activity
I6I53_RS14395	COG1686	Belongs to the peptidase S11 family
I6I53_RS14405	COG0589	response to stress
I6I53_RS14415	COG0671	phosphoesterase, PA-phosphatase related
I6I53_RS14425	COG2194	sulfuric ester hydrolase activity
I6I53_RS14430	COG0745	RESPONSE REGULATOR receiver
I6I53_RS14435	COG0642	Histidine kinase
I6I53_RS14470	COG1131	(ABC) transporter
I6I53_RS14475	COG0842	Transport permease protein
I6I53_RS14480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I53_RS14480	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I53_RS14490	COG0772	Belongs to the SEDS family
I6I53_RS14495	COG2951	lytic endotransglycosylase activity
I6I53_RS14530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I53_RS14535	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I53_RS14540	COG0024	Methionine aminopeptidase
I6I53_RS14555	COG2175	clavaminate synthase activity
I6I53_RS14565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I53_RS14585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I53_RS14595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I53_RS14605	COG3293	Transposase
I6I53_RS14610	COG4122	O-methyltransferase activity
I6I53_RS14630	COG1137	ATPase activity
I6I53_RS14635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I53_RS14645	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I53_RS14665	COG4993	Dehydrogenase
I6I53_RS14670	COG2175	clavaminate synthase activity
I6I53_RS14675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_RS14680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I53_RS14685	COG4521	taurine ABC transporter
I6I53_RS14700	COG2255	four-way junction helicase activity
I6I53_RS14705	COG0824	Thioesterase
I6I53_RS14725	COG0823	Involved in the tonB-independent uptake of proteins
I6I53_RS14745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I53_RS14765	COG3706	GGDEF domain
I6I53_RS14765	COG4251	negative regulation of phosphorylation
I6I53_RS14765	COG5001	Diguanylate cyclase
I6I53_RS14765	COG2203	Gaf domain
I6I53_RS14770	COG0418	dihydroorotase activity
I6I53_RS14775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I53_RS14785	COG0833	amino acid
I6I53_RS14795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I53_RS14800	COG0243	molybdopterin cofactor binding
I6I53_RS14810	COG1643	Atp-dependent helicase
I6I53_RS14850	COG3293	Transposase
I6I53_RS14855	COG3022	response to hydroperoxide
I6I53_RS14860	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I53_RS14870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I53_RS14890	COG1960	acyl-CoA dehydrogenase activity
I6I53_RS14900	COG2985	domain, Protein
I6I53_RS14905	COG1764	response to oxidative stress
I6I53_RS14930	COG0632	four-way junction helicase activity
I6I53_RS14935	COG4302	ethanolamine ammonia-lyase activity
I6I53_RS14940	COG4303	Ethanolamine ammonia lyase large subunit
I6I53_RS14945	COG0531	amino acid
I6I53_RS14950	COG2070	2-Nitropropane dioxygenase
I6I53_RS15210	COG5377	YqaJ viral recombinase family
I6I53_RS15245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I53_RS15275	COG2962	Rard protein
I6I53_RS15280	COG3040	lipid binding
I6I53_RS15285	COG0556	nucleotide-excision repair
I6I53_RS15295	COG2199	diguanylate cyclase activity
I6I53_RS15300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I53_RS15310	COG0436	Aminotransferase
I6I53_RS15325	COG0174	glutamine synthetase
I6I53_RS15360	COG1484	DNA-dependent DNA replication
I6I53_RS15365	COG0582	viral genome integration into host DNA
I6I53_RS15370	COG1074	ATP-dependent DNA helicase activity
I6I53_RS15390	COG1230	cation diffusion facilitator family transporter
I6I53_RS15405	COG2814	Major facilitator Superfamily
I6I53_RS15500	COG0459	protein refolding
I6I53_RS15505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I53_RS15520	COG1597	lipid kinase activity
I6I53_RS15525	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I53_RS15550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I53_RS15570	COG1929	Belongs to the glycerate kinase type-1 family
I6I53_RS15590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I53_RS15595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I53_RS15600	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I53_RS15620	COG0505	Belongs to the CarA family
I6I53_RS15635	COG0589	response to stress
I6I53_RS15645	COG0589	response to stress
I6I53_RS15655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I53_RS15665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I53_RS15670	COG4181	ATPase activity
I6I53_RS15680	COG0288	reversible hydration of carbon dioxide
I6I53_RS15695	COG4771	TonB-dependent receptor
I6I53_RS15720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I53_RS15740	COG0306	phosphate transporter
I6I53_RS15750	COG3586	endonuclease activity
I6I53_RS15765	COG2223	nitrite transmembrane transporter activity
I6I53_RS15775	COG2066	Belongs to the glutaminase family
I6I53_RS15780	COG0242	peptide deformylase activity
I6I53_RS15785	COG0561	phosphatase activity
I6I53_RS15800	COG0400	carboxylic ester hydrolase activity
I6I53_RS15825	COG1215	transferase activity, transferring glycosyl groups
I6I53_RS15830	COG0726	polysaccharide deacetylase
I6I53_RS15830	COG1649	PFAM Uncharacterised BCR, COG1649
I6I53_RS15840	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_RS15850	COG4681	YaeQ
I6I53_RS15860	COG0523	cobalamin synthesis protein
I6I53_RS15875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I53_RS15875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I53_RS15895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I53_RS15910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I53_RS15915	COG1773	rubredoxin
I6I53_RS15920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_RS15930	COG0583	DNA-binding transcription factor activity
I6I53_RS15950	COG1733	regulation of RNA biosynthetic process
I6I53_RS15960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I53_RS15965	COG1648	precorrin-2 dehydrogenase activity
I6I53_RS15965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I53_RS15970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I53_RS15980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I53_RS15990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I53_RS15995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I53_RS16010	COG0671	phosphoesterase, PA-phosphatase related
I6I53_RS16015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_RS16025	COG1538	Outer membrane efflux protein
I6I53_RS16030	COG0393	Putative heavy-metal-binding
I6I53_RS16035	COG0393	Putative heavy-metal-binding
I6I53_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_RS16050	COG0525	valine-tRNA ligase activity
I6I53_RS16075	COG0745	RESPONSE REGULATOR receiver
I6I53_RS16080	COG2814	Major facilitator Superfamily
I6I53_RS16090	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I53_RS16105	COG0142	geranyltranstransferase activity
I6I53_RS16160	COG3328	transposase activity
I6I53_RS16165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I53_RS16225	COG3676	manually curated
I6I53_RS16230	COG0154	amidase activity
I6I53_RS16245	COG0431	NADPH-dependent FMN reductase
I6I53_RS16265	COG1192	Involved in chromosome partitioning
I6I53_RS16270	COG1475	DNA binding
I6I53_RS16315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I53_RS16320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I53_RS16350	COG4680	protein conserved in bacteria
I6I53_RS16365	COG1063	alcohol dehydrogenase
I6I53_RS16385	COG2323	membrane
I6I53_RS16430	COG2223	nitrite transmembrane transporter activity
I6I53_RS16435	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I53_RS16440	COG1877	trehalose-phosphatase activity
I6I53_RS16460	COG1570	exodeoxyribonuclease VII activity
I6I53_RS16555	COG2336	PFAM SpoVT AbrB
I6I53_RS16560	COG2337	Toxic component of a toxin-antitoxin (TA) module