locus-tag	class	description
URS_RS00205	COG2217	Heavy metal translocating P-type atpase
URS_RS00235	COG2267	carboxylic ester hydrolase activity
URS_RS00245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
URS_RS00260	COG1113	amino acid transport
URS_RS00280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
URS_RS00285	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
URS_RS00290	COG2072	flavoprotein involved in K transport
URS_RS00305	COG1309	transcriptional regulator
URS_RS00320	COG1024	Enoyl-CoA hydratase
URS_RS00325	COG1012	belongs to the aldehyde dehydrogenase family
URS_RS00335	COG1960	acyl-CoA dehydrogenase activity
URS_RS00360	COG1595	DNA-templated transcription, initiation
URS_RS00375	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS00380	COG2610	gluconate transmembrane transporter activity
URS_RS00385	COG0583	DNA-binding transcription factor activity
URS_RS00400	COG2031	fatty acid transporter
URS_RS00405	COG0183	Belongs to the thiolase family
URS_RS00410	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
URS_RS00415	COG4149	molybdate abc transporter
URS_RS00420	COG0725	ABC transporter, periplasmic molybdate-binding protein
URS_RS00435	COG0477	Major facilitator Superfamily
URS_RS00440	COG0583	DNA-binding transcription factor activity
URS_RS00445	COG1960	acyl-CoA dehydrogenase activity
URS_RS00450	COG2301	Belongs to the HpcH HpaI aldolase family
URS_RS00455	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
URS_RS00480	COG0596	Alpha beta hydrolase
URS_RS00485	COG0583	DNA-binding transcription factor activity
URS_RS00495	COG4974	Belongs to the 'phage' integrase family
URS_RS00525	COG0446	pyridine nucleotide-disulphide oxidoreductase
URS_RS00525	COG1902	pentaerythritol trinitrate reductase activity
URS_RS00530	COG0697	spore germination
URS_RS00535	COG0583	DNA-binding transcription factor activity
URS_RS00560	COG0628	permease
URS_RS00565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
URS_RS00570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
URS_RS00585	COG4372	Transposase
URS_RS00635	COG0717	Belongs to the dCTP deaminase family
URS_RS00650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
URS_RS00655	COG0489	protein tyrosine kinase activity
URS_RS00665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
URS_RS00665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
URS_RS00670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
URS_RS00705	COG1280	lysine exporter protein (LysE YggA)
URS_RS00710	COG2226	methyltransferase
URS_RS00730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
URS_RS00735	COG2081	HI0933 family
URS_RS00740	COG0668	transmembrane transport
URS_RS00760	COG0583	DNA-binding transcription factor activity
URS_RS00775	COG2826	transposase and inactivated derivatives, IS30 family
URS_RS00785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
URS_RS00795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_RS00800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
URS_RS00805	COG0713	ATP synthesis coupled electron transport
URS_RS00815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_RS00830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
URS_RS00840	COG0649	NAD binding
URS_RS00840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_RS00845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_RS00850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_RS00860	COG2205	protein histidine kinase activity
URS_RS00865	COG0745	RESPONSE REGULATOR receiver
URS_RS00870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
URS_RS00870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
URS_RS00880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
URS_RS00885	COG1074	ATP-dependent DNA helicase activity
URS_RS00920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
URS_RS00945	COG2132	Multicopper oxidase
URS_RS00955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
URS_RS00970	COG4269	membrane
URS_RS00985	COG0742	ribosomal rna small subunit methyltransferase
URS_RS00990	COG1968	undecaprenyl-diphosphatase activity
URS_RS00995	COG1214	PFAM Peptidase M22, glycoprotease
URS_RS01055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
URS_RS01065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
URS_RS01070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
URS_RS01130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
URS_RS01135	COG1846	Transcriptional regulator
URS_RS01175	COG0037	tRNA processing
URS_RS01185	COG0248	Ppx GppA phosphatase
URS_RS01205	COG0776	regulation of translation
URS_RS01210	COG0072	phenylalanine-tRNA ligase activity
URS_RS01215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
URS_RS01240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
URS_RS01255	COG1238	metal cluster binding
URS_RS01260	COG0625	glutathione transferase activity
URS_RS01270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
URS_RS01290	COG3028	Belongs to the UPF0307 family
URS_RS01295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
URS_RS01300	COG1660	Displays ATPase and GTPase activities
URS_RS01305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
URS_RS01315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
URS_RS01320	COG0617	tRNA 3'-terminal CCA addition
URS_RS01325	COG1555	photosystem II stabilization
URS_RS01330	COG3956	TIGRFAM MazG family protein
URS_RS01345	COG2315	Protein conserved in bacteria
URS_RS01350	COG0745	RESPONSE REGULATOR receiver
URS_RS01355	COG2205	protein histidine kinase activity
URS_RS01365	COG1960	acyl-CoA dehydrogenase activity
URS_RS01370	COG1960	acyl-CoA dehydrogenase activity
URS_RS01420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
URS_RS01435	COG1442	glycosyl transferase family 8
URS_RS01440	COG1216	Glycosyl transferase, family 2
URS_RS01445	COG0438	transferase activity, transferring glycosyl groups
URS_RS01455	COG0438	transferase activity, transferring glycosyl groups
URS_RS01460	COG0726	polysaccharide deacetylase
URS_RS01475	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
URS_RS01480	COG2205	protein histidine kinase activity
URS_RS01485	COG3706	GGDEF domain
URS_RS01520	COG0697	spore germination
URS_RS01525	COG0789	Transcriptional regulator
URS_RS01535	COG2814	Major facilitator Superfamily
URS_RS01545	COG1230	cation diffusion facilitator family transporter
URS_RS01560	COG4774	siderophore transport
URS_RS01570	COG0745	RESPONSE REGULATOR receiver
URS_RS01585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
URS_RS01615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
URS_RS01630	COG0732	type I restriction modification DNA specificity domain
URS_RS01640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
URS_RS01720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
URS_RS01730	COG1704	LemA family
URS_RS01740	COG1862	Preprotein translocase
URS_RS01770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
URS_RS01775	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS01795	COG0644	oxidoreductase
URS_RS01815	COG2986	histidine ammonia-lyase
URS_RS01840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
URS_RS01875	COG0124	histidyl-tRNA synthetase
URS_RS01885	COG1426	Protein conserved in bacteria
URS_RS01905	COG0105	UTP biosynthetic process
URS_RS01925	COG0793	Belongs to the peptidase S41A family
URS_RS01940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
URS_RS01945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
URS_RS01950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
URS_RS01955	COG0857	belongs to the CobB CobQ family
URS_RS01955	COG0280	phosphate acetyltransferase
URS_RS01960	COG1335	isochorismatase
URS_RS01970	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
URS_RS01970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
URS_RS01975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
URS_RS01980	COG1162	GTPase activity
URS_RS01990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
URS_RS02000	COG3783	Cytochrome b(562)
URS_RS02005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
URS_RS02010	COG2003	Belongs to the UPF0758 family
URS_RS02015	COG3781	membrane
URS_RS02020	COG0667	Aldo Keto reductase
URS_RS02025	COG0583	DNA-binding transcription factor activity
URS_RS02040	COG2350	Protein conserved in bacteria
URS_RS02055	COG0560	Phosphoserine phosphatase
URS_RS02065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
URS_RS02075	COG1530	ribonuclease E activity
URS_RS02080	COG0424	maF-like protein
URS_RS02090	COG1792	Involved in formation and maintenance of cell shape
URS_RS02095	COG1077	Cell shape determining protein MreB Mrl
URS_RS02100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
URS_RS02105	COG0154	amidase activity
URS_RS02110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
URS_RS02160	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
URS_RS02195	COG1902	pentaerythritol trinitrate reductase activity
URS_RS02200	COG4772	TonB-dependent receptor
URS_RS02205	COG2094	Belongs to the DNA glycosylase MPG family
URS_RS02210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
URS_RS02230	COG1217	gtp-binding protein TYPA
URS_RS02235	COG2233	PERMEase
URS_RS02240	COG2813	Specifically methylates the guanine in position
URS_RS02245	COG0833	amino acid
URS_RS02250	COG1690	Belongs to the RtcB family
URS_RS02260	COG0643	Histidine kinase
URS_RS02260	COG2198	Histidine kinase
URS_RS02265	COG0840	transmembrane signaling receptor activity
URS_RS02300	COG0442	prolyl-tRNA aminoacylation
URS_RS02310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_RS02330	COG2207	Transcriptional regulator
URS_RS02345	COG0183	Belongs to the thiolase family
URS_RS02360	COG4667	esterase of the alpha-beta hydrolase superfamily
URS_RS02370	COG2153	protein acetylation
URS_RS02380	COG1272	protein, Hemolysin III
URS_RS02385	COG0477	Major facilitator Superfamily
URS_RS02390	COG1408	metallophosphoesterase
URS_RS02395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
URS_RS02410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
URS_RS02430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
URS_RS02435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
URS_RS02440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
URS_RS02450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
URS_RS02455	COG0625	glutathione transferase activity
URS_RS02460	COG2969	positive regulation of protein catabolic process
URS_RS02520	COG1183	phosphatidylcholine synthase activity
URS_RS02525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
URS_RS02545	COG0039	L-malate dehydrogenase activity
URS_RS02555	COG0739	heme binding
URS_RS02555	COG0741	lytic transglycosylase activity
URS_RS02555	COG1196	nuclear chromosome segregation
URS_RS02560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
URS_RS02565	COG1702	phosphate starvation-inducible protein PhoH
URS_RS02570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
URS_RS02605	COG1295	ribonuclease BN
URS_RS02625	COG2814	Major facilitator Superfamily
URS_RS02635	COG0179	Fumarylacetoacetate (FAA) hydrolase
URS_RS02680	COG0557	exoribonuclease II activity
URS_RS02690	COG0339	signal peptide processing
URS_RS02695	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
URS_RS02725	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
URS_RS02730	COG1960	acyl-CoA dehydrogenase activity
URS_RS02735	COG2072	flavoprotein involved in K transport
URS_RS02740	COG0203	ribosomal protein L17
URS_RS02745	COG0202	RNA polymerase activity
URS_RS02750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
URS_RS02760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
URS_RS02785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
URS_RS02795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
URS_RS02800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
URS_RS02810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
URS_RS02815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
URS_RS02820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
URS_RS02825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
URS_RS02835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
URS_RS02845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
URS_RS02850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
URS_RS02865	COG0088	Forms part of the polypeptide exit tunnel
URS_RS02870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
URS_RS02875	COG0051	transcription antitermination factor activity, RNA binding
URS_RS02890	COG0433	COG0433 Predicted ATPase
URS_RS02895	COG1017	nitric oxide dioxygenase activity
URS_RS02895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
URS_RS02900	COG1959	2 iron, 2 sulfur cluster binding
URS_RS02915	COG1301	dicarboxylic acid transport
URS_RS02920	COG1946	Acyl-CoA thioesterase
URS_RS02925	COG2937	Belongs to the GPAT DAPAT family
URS_RS02940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
URS_RS02945	COG1040	competence protein
URS_RS02950	COG0494	nUDIX hydrolase
URS_RS02960	COG0598	Magnesium transport protein CorA
URS_RS02980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
URS_RS02985	COG1127	ABC transporter
URS_RS02995	COG0513	Belongs to the DEAD box helicase family
URS_RS03010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
URS_RS03015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
URS_RS03020	COG0408	coproporphyrinogen oxidase activity
URS_RS03030	COG2885	chlorophyll binding
URS_RS03045	COG1960	acyl-CoA dehydrogenase activity
URS_RS03055	COG1983	PspC domain protein
URS_RS03060	COG0517	IMP dehydrogenase activity
URS_RS03075	COG0752	glycyl-tRNA synthetase alpha subunit
URS_RS03095	COG0583	DNA-binding transcription factor activity
URS_RS03110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
URS_RS03155	COG1192	Involved in chromosome partitioning
URS_RS03160	COG0628	permease
URS_RS03175	COG3293	Transposase
URS_RS03195	COG1289	transmembrane transporter activity
URS_RS03200	COG2814	Major facilitator Superfamily
URS_RS03210	COG2249	NAD(P)H dehydrogenase (quinone) activity
URS_RS03215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
URS_RS03230	COG0277	FAD linked oxidase domain protein
URS_RS03235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
URS_RS03240	COG5006	permease, DMT superfamily
URS_RS03260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
URS_RS03265	COG5380	lipid catabolic process
URS_RS03270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
URS_RS03275	COG0335	large ribosomal subunit rRNA binding
URS_RS03285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
URS_RS03290	COG0228	four-way junction DNA binding
URS_RS03330	COG4968	Prepilin-type N-terminal cleavage methylation domain
URS_RS03335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
URS_RS03340	COG0194	GDP metabolic process
URS_RS03345	COG1758	RNA polymerase activity
URS_RS03350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
URS_RS03375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
URS_RS03395	COG2826	transposase and inactivated derivatives, IS30 family
URS_RS03410	COG0326	Molecular chaperone. Has ATPase activity
URS_RS03445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
URS_RS03450	COG0085	RNA polymerase activity
URS_RS03465	COG0081	regulation of translation
URS_RS03470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
URS_RS03490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
URS_RS03525	COG1716	ATPase activity
URS_RS03570	COG0181	hydroxymethylbilane synthase activity
URS_RS03580	COG3275	phosphorelay sensor kinase activity
URS_RS03610	COG0494	nUDIX hydrolase
URS_RS03615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
URS_RS03620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
URS_RS03625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
URS_RS03630	COG0772	Belongs to the SEDS family
URS_RS03635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
URS_RS03655	COG4974	Belongs to the 'phage' integrase family
URS_RS03660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
URS_RS03670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
URS_RS03680	COG2197	response regulator
URS_RS03695	COG0793	Belongs to the peptidase S41A family
URS_RS03700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
URS_RS03705	COG0795	lipopolysaccharide-transporting ATPase activity
URS_RS03710	COG0795	lipopolysaccharide-transporting ATPase activity
URS_RS03745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
URS_RS03745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
URS_RS03760	COG0347	Belongs to the P(II) protein family
URS_RS03770	COG0606	chelatase, subunit chli
URS_RS03785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
URS_RS03800	COG0318	PFAM AMP-dependent synthetase and ligase
URS_RS03810	COG0477	Major facilitator Superfamily
URS_RS03820	COG2860	membrane
URS_RS03830	COG1253	flavin adenine dinucleotide binding
URS_RS03850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
URS_RS03855	COG0477	Major facilitator Superfamily
URS_RS03905	COG1309	transcriptional regulator
URS_RS03935	COG1652	LysM domain
URS_RS03940	COG0758	DNA mediated transformation
URS_RS03945	COG0009	L-threonylcarbamoyladenylate synthase
URS_RS03950	COG1079	Belongs to the binding-protein-dependent transport system permease family
URS_RS03955	COG4603	Belongs to the binding-protein-dependent transport system permease family
URS_RS03960	COG3845	ABC transporter
URS_RS04000	COG0697	spore germination
URS_RS04005	COG1309	transcriptional regulator
URS_RS04010	COG2814	Major facilitator Superfamily
URS_RS04020	COG0386	Belongs to the glutathione peroxidase family
URS_RS04035	COG3328	transposase activity
URS_RS04055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
URS_RS04060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
URS_RS04110	COG1121	(ABC) transporter
URS_RS04115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
URS_RS04120	COG1280	lysine exporter protein (LysE YggA)
URS_RS04130	COG0281	malic enzyme
URS_RS04140	COG0018	arginyl-trna synthetase
URS_RS04190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
URS_RS04190	COG0519	Catalyzes the synthesis of GMP from XMP
URS_RS04195	COG3111	PFAM Bacterial OB fold (BOF) protein
URS_RS04200	COG2259	Doxx family
URS_RS04205	COG0586	Pfam SNARE associated Golgi protein
URS_RS04225	COG1192	Involved in chromosome partitioning
URS_RS04270	COG3756	Protein conserved in bacteria
URS_RS04280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_RS04295	COG0753	catalase activity
URS_RS04345	COG3550	peptidyl-serine autophosphorylation
URS_RS04350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
URS_RS04365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
URS_RS04365	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
URS_RS04365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
URS_RS04370	COG1105	Belongs to the carbohydrate kinase PfkB family
URS_RS04375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
URS_RS04375	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
URS_RS04395	COG4716	Myosin-crossreactive antigen
URS_RS04475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
URS_RS04490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
URS_RS04495	COG3162	membrane
URS_RS04500	COG2205	protein histidine kinase activity
URS_RS04500	COG0784	Response regulator, receiver
URS_RS04515	COG0004	ammonium transporteR
URS_RS04545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
URS_RS04555	COG0668	transmembrane transport
URS_RS04565	COG1519	Transferase
URS_RS04575	COG1902	pentaerythritol trinitrate reductase activity
URS_RS04600	COG1476	TRANSCRIPTIONal
URS_RS04605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
URS_RS04610	COG0259	pyridoxamine-phosphate oxidase activity
URS_RS04630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_RS04630	COG0426	domain, Protein
URS_RS04635	COG2119	membrane
URS_RS04670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
URS_RS04680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
URS_RS04685	COG1181	Belongs to the D-alanine--D-alanine ligase family
URS_RS04695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
URS_RS04700	COG0189	ligase activity
URS_RS04725	COG0708	Exodeoxyribonuclease III
URS_RS04730	COG1393	Belongs to the ArsC family
URS_RS04745	COG3706	GGDEF domain
URS_RS04750	COG0625	glutathione transferase activity
URS_RS04800	COG1247	-acetyltransferase
URS_RS04815	COG4266	Belongs to the allantoicase family
URS_RS04820	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
URS_RS04840	COG3150	esterase
URS_RS04850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
URS_RS04855	COG2918	glutathione biosynthetic process
URS_RS04870	COG2733	membrane
URS_RS04875	COG0436	Aminotransferase
URS_RS04910	COG0300	oxidoreductase activity
URS_RS04920	COG0688	phosphatidylethanolamine metabolic process
URS_RS04930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
URS_RS04950	COG0560	Phosphoserine phosphatase
URS_RS04950	COG3830	Belongs to the UPF0237 family
URS_RS04965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
URS_RS04970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
URS_RS04975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
URS_RS04980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
URS_RS04990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
URS_RS05005	COG3121	Chaperone
URS_RS05015	COG3188	usher protein
URS_RS05035	COG2388	GCN5-related N-acetyl-transferase
URS_RS05040	COG0385	Bile acid
URS_RS05045	COG1335	isochorismatase
URS_RS05050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
URS_RS05060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
URS_RS05065	COG2116	formate transmembrane transporter activity
URS_RS05070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
URS_RS05080	COG2133	pyrroloquinoline quinone binding
URS_RS05095	COG2983	Belongs to the UPF0260 family
URS_RS05100	COG5487	UPF0391 membrane protein
URS_RS05105	COG0412	Dienelactone hydrolase
URS_RS05115	COG1194	a g-specific adenine glycosylase
URS_RS05130	COG2818	Glycosylase
URS_RS05135	COG1064	alcohol dehydrogenase
URS_RS05140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_RS05150	COG0583	DNA-binding transcription factor activity
URS_RS05155	COG2814	Major facilitator Superfamily
URS_RS05165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
URS_RS05170	COG0484	heat shock protein binding
URS_RS05185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_RS05190	COG1309	transcriptional regulator
URS_RS05195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
URS_RS05200	COG2233	PERMEase
URS_RS05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
URS_RS05220	COG1252	NADH dehydrogenase
URS_RS05235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
URS_RS05240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
URS_RS05245	COG0428	transporter
URS_RS05255	COG0733	neurotransmitter:sodium symporter activity
URS_RS05260	COG1012	belongs to the aldehyde dehydrogenase family
URS_RS05275	COG0693	protein deglycase activity
URS_RS05305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
URS_RS05310	COG0657	acetylesterase activity
URS_RS05330	COG0583	DNA-binding transcription factor activity
URS_RS05335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
URS_RS05340	COG0443	Heat shock 70 kDa protein
URS_RS05355	COG2951	lytic endotransglycosylase activity
URS_RS05360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
URS_RS05375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
URS_RS05400	COG0861	Integral membrane protein TerC family
URS_RS05410	COG0402	S-adenosylhomocysteine deaminase activity
URS_RS05425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
URS_RS05435	COG0706	membrane insertase activity
URS_RS05440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
URS_RS05445	COG0594	ribonuclease P activity
URS_RS05455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
URS_RS05460	COG0592	DNA-directed DNA polymerase activity
URS_RS05465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
URS_RS05470	COG0187	DNA topoisomerase II activity
URS_RS05480	COG0488	(ABC) transporter
URS_RS05500	COG0316	Belongs to the HesB IscA family
URS_RS05505	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
URS_RS05510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
URS_RS05590	COG1047	Peptidyl-prolyl cis-trans
URS_RS05595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
URS_RS05600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
URS_RS05605	COG0196	riboflavin kinase activity
URS_RS05620	COG0596	Alpha beta hydrolase
URS_RS05625	COG1309	transcriptional regulator
URS_RS05630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_RS05635	COG1335	isochorismatase
URS_RS05640	COG0251	oxidation-reduction process
URS_RS05645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_RS05650	COG2233	PERMEase
URS_RS05660	COG1116	anion transmembrane transporter activity
URS_RS05665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_RS05670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_RS05675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_RS05680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_RS05685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
URS_RS05685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
URS_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS05705	COG0546	phosphoglycolate phosphatase activity
URS_RS05710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
URS_RS05740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
URS_RS05760	COG3023	N-Acetylmuramoyl-L-alanine amidase
URS_RS05790	COG1596	polysaccharide export
URS_RS05795	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
URS_RS05800	COG1088	dTDP-glucose 4,6-dehydratase activity
URS_RS05805	COG1091	dTDP-4-dehydrorhamnose reductase activity
URS_RS05840	COG4641	Protein conserved in bacteria
URS_RS05840	COG0438	transferase activity, transferring glycosyl groups
URS_RS05845	COG0438	transferase activity, transferring glycosyl groups
URS_RS05850	COG0297	glycogen (starch) synthase activity
URS_RS05865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
URS_RS05880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
URS_RS05895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
URS_RS05900	COG0583	DNA-binding transcription factor activity
URS_RS05905	COG1620	l-lactate permease
URS_RS05910	COG2186	Transcriptional regulator
URS_RS05915	COG1304	FMN binding
URS_RS05920	COG0277	FAD linked oxidase domain protein
URS_RS05940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_RS05950	COG0251	oxidation-reduction process
URS_RS05955	COG1113	amino acid transport
URS_RS05960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
URS_RS05985	COG1538	Outer membrane efflux protein
URS_RS06020	COG1335	isochorismatase
URS_RS06030	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
URS_RS06050	COG3706	GGDEF domain
URS_RS06085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
URS_RS06095	COG2814	Major facilitator Superfamily
URS_RS06110	COG0179	Fumarylacetoacetate (FAA) hydrolase
URS_RS06120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_RS06210	COG3177	Filamentation induced by cAMP protein fic
URS_RS06295	COG0582	viral genome integration into host DNA
URS_RS06305	COG3158	transport of potassium into the cell
URS_RS06340	COG0107	imidazoleglycerol-phosphate synthase activity
URS_RS06345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
URS_RS06370	COG0531	amino acid
URS_RS06375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_RS06380	COG1132	(ABC) transporter
URS_RS06390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
URS_RS06400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
URS_RS06405	COG0131	Imidazoleglycerol-phosphate dehydratase
URS_RS06435	COG0456	acetyltransferase
URS_RS06440	COG0427	acetyl-CoA hydrolase
URS_RS06470	COG4221	oxidoreductase activity
URS_RS06480	COG0028	Belongs to the TPP enzyme family
URS_RS06485	COG0488	(ABC) transporter
URS_RS06535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
URS_RS06550	COG0275	rRNA processing
URS_RS06565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
URS_RS06570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
URS_RS06575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
URS_RS06580	COG2226	methyltransferase
URS_RS06615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
URS_RS06620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
URS_RS06630	COG0070	glutamate synthase
URS_RS06630	COG0069	glutamate synthase activity
URS_RS06630	COG0067	glutamate synthase
URS_RS06635	COG0493	'glutamate synthase
URS_RS06640	COG0583	DNA-binding transcription factor activity
URS_RS06645	COG1960	acyl-CoA dehydrogenase activity
URS_RS06650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
URS_RS06655	COG0477	Major facilitator Superfamily
URS_RS06660	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS06670	COG1704	LemA family
URS_RS06675	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
URS_RS06755	COG4969	Belongs to the N-Me-Phe pilin family
URS_RS06760	COG4969	Belongs to the N-Me-Phe pilin family
URS_RS06765	COG3307	-O-antigen
URS_RS06775	COG3307	-O-antigen
URS_RS06780	COG3177	Filamentation induced by cAMP protein fic
URS_RS06810	COG0322	excinuclease ABC activity
URS_RS06820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
URS_RS06825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
URS_RS06825	COG2169	Transcriptional regulator
URS_RS06835	COG1132	(ABC) transporter
URS_RS06845	COG1289	transmembrane transporter activity
URS_RS06860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
URS_RS06865	COG1678	Uncharacterized ACR, COG1678
URS_RS06870	COG0497	DNA recombination
URS_RS06875	COG3123	guanosine phosphorylase activity
URS_RS06880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
URS_RS06890	COG0237	dephospho-CoA kinase activity
URS_RS06910	COG0149	triose-phosphate isomerase activity
URS_RS06935	COG0779	Required for maturation of 30S ribosomal subunits
URS_RS06940	COG0195	Participates in both transcription termination and antitermination
URS_RS06955	COG1320	monovalent cation:proton antiporter activity
URS_RS06960	COG2212	antiporter activity
URS_RS06965	COG1863	multisubunit Na H antiporter MnhE subunit
URS_RS06970	COG0651	ATP synthesis coupled electron transport
URS_RS06975	COG1006	Multisubunit Na H antiporter MnhC subunit
URS_RS06980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
URS_RS06980	COG2111	Na H antiporter
URS_RS07005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
URS_RS07015	COG2226	methyltransferase
URS_RS07040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
URS_RS07045	COG1074	ATP-dependent DNA helicase activity
URS_RS07050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
URS_RS07055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
URS_RS07060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
URS_RS07065	COG1185	polyribonucleotide nucleotidyltransferase activity
URS_RS07070	COG2841	Protein conserved in bacteria
URS_RS07075	COG0598	Magnesium transport protein CorA
URS_RS07080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
URS_RS07095	COG0484	heat shock protein binding
URS_RS07100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
URS_RS07110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
URS_RS07130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
URS_RS07135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
URS_RS07140	COG4535	Mg2 and Co2 transporter CorC
URS_RS07145	COG0425	Belongs to the sulfur carrier protein TusA family
URS_RS07160	COG0644	oxidoreductase
URS_RS07160	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
URS_RS07170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
URS_RS07180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
URS_RS07185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
URS_RS07190	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
URS_RS07200	COG0493	'glutamate synthase
URS_RS07200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
URS_RS07220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_RS07235	COG0254	rRNA binding
URS_RS07240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
URS_RS07255	COG0534	Mate efflux family protein
URS_RS07265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
URS_RS07275	COG1595	DNA-templated transcription, initiation
URS_RS07285	COG4221	oxidoreductase activity
URS_RS07290	COG0583	DNA-binding transcription factor activity
URS_RS07295	COG0450	alkyl hydroperoxide reductase
URS_RS07310	COG0318	PFAM AMP-dependent synthetase and ligase
URS_RS07315	COG1530	ribonuclease E activity
URS_RS07325	COG0564	pseudouridine synthase activity
URS_RS07340	COG0583	DNA-binding transcription factor activity
URS_RS07355	COG4993	Dehydrogenase
URS_RS07360	COG0753	catalase activity
URS_RS07370	COG1960	acyl-CoA dehydrogenase activity
URS_RS07380	COG0494	nUDIX hydrolase
URS_RS07410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
URS_RS07425	COG0473	3-isopropylmalate dehydrogenase activity
URS_RS07435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
URS_RS07445	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS07450	COG0101	tRNA pseudouridine synthase activity
URS_RS07485	COG1301	dicarboxylic acid transport
URS_RS07490	COG0438	transferase activity, transferring glycosyl groups
URS_RS07495	COG1560	Kdo2-lipid A biosynthetic process
URS_RS07505	COG0488	(ABC) transporter
URS_RS07510	COG2900	Belongs to the SlyX family
URS_RS07540	COG2203	Gaf domain
URS_RS07540	COG3706	GGDEF domain
URS_RS07540	COG4251	negative regulation of phosphorylation
URS_RS07540	COG5001	Diguanylate cyclase
URS_RS07550	COG0210	DNA helicase
URS_RS07570	COG4651	solute:proton antiporter activity
URS_RS07570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
URS_RS07595	COG0788	formyltetrahydrofolate deformylase activity
URS_RS07635	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
URS_RS07650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
URS_RS07685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
URS_RS07695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
URS_RS07695	COG2813	Specifically methylates the guanine in position
URS_RS07700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
URS_RS07705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
URS_RS07710	COG3128	pkhd-type hydroxylase
URS_RS07715	COG4774	siderophore transport
URS_RS07720	COG0544	peptidyl-prolyl cis-trans isomerase activity
URS_RS07725	COG0740	serine-type endopeptidase activity
URS_RS07750	COG3622	Belongs to the hyi family
URS_RS07765	COG5002	protein histidine kinase activity
URS_RS07765	COG2205	protein histidine kinase activity
URS_RS07765	COG0784	Response regulator, receiver
URS_RS07785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
URS_RS07805	COG2096	Adenosyltransferase
URS_RS07810	COG4206	TonB-dependent receptor
URS_RS07850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
URS_RS07855	COG0285	dihydrofolate synthase activity
URS_RS07875	COG0450	alkyl hydroperoxide reductase
URS_RS07880	COG0653	protein targeting
URS_RS07890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
URS_RS07895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
URS_RS07920	COG2885	chlorophyll binding
URS_RS07925	COG2199	diguanylate cyclase activity
URS_RS07965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
URS_RS07990	COG1607	acyl-coa hydrolase
URS_RS07995	COG1956	GAF domain-containing protein
URS_RS08035	COG0183	Belongs to the thiolase family
URS_RS08050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
URS_RS08055	COG5510	response to toxic substance
URS_RS08065	COG2832	Protein of unknown function (DUF454)
URS_RS08070	COG1376	ErfK ybiS ycfS ynhG family protein
URS_RS08115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
URS_RS08125	COG1289	transmembrane transporter activity
URS_RS08130	COG2814	Major facilitator Superfamily
URS_RS08145	COG0786	glutamate:sodium symporter activity
URS_RS08150	COG1115	amino acid carrier protein
URS_RS08155	COG1752	Esterase of the alpha-beta hydrolase superfamily
URS_RS08170	COG2824	Alkylphosphonate utilization operon protein PhnA
URS_RS08175	COG0494	nUDIX hydrolase
URS_RS08180	COG3422	double-strand break repair
URS_RS08195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
URS_RS08205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
URS_RS08210	COG3545	Serine hydrolase
URS_RS08220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
URS_RS08220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
URS_RS08225	COG0730	response to heat
URS_RS08235	COG1196	nuclear chromosome segregation
URS_RS08245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
URS_RS08260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
URS_RS08275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
URS_RS08275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
URS_RS08285	COG4106	trans-aconitate 2-methyltransferase activity
URS_RS08305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
URS_RS08310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
URS_RS08320	COG0009	L-threonylcarbamoyladenylate synthase
URS_RS08325	COG3101	peptidyl-lysine hydroxylation
URS_RS08330	COG1399	metal-binding, possibly nucleic acid-binding protein
URS_RS08345	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS08355	COG1652	LysM domain
URS_RS08365	COG1733	regulation of RNA biosynthetic process
URS_RS08370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
URS_RS08370	COG0352	thiamine-phosphate diphosphorylase activity
URS_RS08370	COG0351	phosphomethylpyrimidine kinase
URS_RS08390	COG1981	membrane
URS_RS08415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
URS_RS08420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
URS_RS08430	COG0456	acetyltransferase
URS_RS08435	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
URS_RS08440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
URS_RS08445	COG0500	methyltransferase
URS_RS08450	COG0492	ferredoxin-NADP+ reductase activity
URS_RS08455	COG0531	amino acid
URS_RS08455	COG1674	ftsk spoiiie
URS_RS08465	COG1280	lysine exporter protein (LysE YggA)
URS_RS08475	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
URS_RS08480	COG2894	cell division
URS_RS08485	COG0850	regulation of cytokinetic process
URS_RS08495	COG0204	Acyl-transferase
URS_RS08500	COG2885	chlorophyll binding
URS_RS08510	COG0756	dUTP diphosphatase activity
URS_RS08515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
URS_RS08520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
URS_RS08530	COG0121	glutamine amidotransferase
URS_RS08550	COG2914	Belongs to the UPF0125 (RnfH) family
URS_RS08555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
URS_RS08560	COG0735	belongs to the Fur family
URS_RS08580	COG1968	undecaprenyl-diphosphatase activity
URS_RS08600	COG0420	3'-5' exonuclease activity
URS_RS08630	COG2050	protein possibly involved in aromatic compounds catabolism
URS_RS08635	COG1566	PFAM secretion protein HlyD family protein
URS_RS08640	COG2814	Major facilitator Superfamily
URS_RS08645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_RS08675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
URS_RS08680	COG2223	nitrite transmembrane transporter activity
URS_RS08690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
URS_RS08695	COG1301	dicarboxylic acid transport
URS_RS08700	COG0436	Aminotransferase
URS_RS08705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
URS_RS08710	COG0583	DNA-binding transcription factor activity
URS_RS08740	COG2223	nitrite transmembrane transporter activity
URS_RS08755	COG0577	efflux transmembrane transporter activity
URS_RS08755	COG1136	(ABC) transporter
URS_RS08760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_RS08785	COG0028	Belongs to the TPP enzyme family
URS_RS08795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
URS_RS08995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
URS_RS09040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
URS_RS09055	COG0084	hydrolase, TatD family'
URS_RS09065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
URS_RS09075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
URS_RS09085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
URS_RS09105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
URS_RS09125	COG1414	Transcriptional regulator
URS_RS09145	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS09155	COG0446	pyridine nucleotide-disulphide oxidoreductase
URS_RS09160	COG2271	Major facilitator Superfamily
URS_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS09180	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
URS_RS09185	COG1012	belongs to the aldehyde dehydrogenase family
URS_RS09190	COG0028	Belongs to the TPP enzyme family
URS_RS09205	COG1120	ATPase activity
URS_RS09210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
URS_RS09235	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
URS_RS09240	COG1012	belongs to the aldehyde dehydrogenase family
URS_RS09245	COG1309	transcriptional regulator
URS_RS09250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
URS_RS09260	COG1607	acyl-coa hydrolase
URS_RS09270	COG2009	succinate dehydrogenase
URS_RS09275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
URS_RS09280	COG1053	succinate dehydrogenase
URS_RS09285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
URS_RS09300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
URS_RS09305	COG0045	succinate-CoA ligase (ADP-forming) activity
URS_RS09320	COG1649	PFAM Uncharacterised BCR, COG1649
URS_RS09320	COG0726	polysaccharide deacetylase
URS_RS09325	COG1215	transferase activity, transferring glycosyl groups
URS_RS09340	COG2268	Band 7 protein
URS_RS09345	COG1585	Membrane protein implicated in regulation of membrane protease activity
URS_RS09355	COG2354	Protein conserved in bacteria
URS_RS09360	COG2321	neutral zinc metallopeptidase
URS_RS09365	COG0531	amino acid
URS_RS09385	COG0321	lipoyl(octanoyl) transferase activity
URS_RS09410	COG0500	methyltransferase
URS_RS09415	COG0586	Pfam SNARE associated Golgi protein
URS_RS09430	COG1054	Belongs to the UPF0176 family
URS_RS09440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
URS_RS09450	COG0193	aminoacyl-tRNA hydrolase activity
URS_RS09460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
URS_RS09505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
URS_RS09535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
URS_RS09545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
URS_RS09570	COG1492	cobalamin metabolic process
URS_RS09575	COG0175	sulfate reduction
URS_RS09585	COG2851	Citrate transporter
URS_RS09605	COG0439	Biotin carboxylase
URS_RS09610	COG0864	Transcriptional regulator
URS_RS09620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
URS_RS09640	COG1116	anion transmembrane transporter activity
URS_RS09650	COG1253	flavin adenine dinucleotide binding
URS_RS09670	COG3015	lipoprotein NlpE involved in copper resistance
URS_RS09685	COG0829	nickel cation binding
URS_RS09690	COG0831	urea catabolic process
URS_RS09695	COG0832	Belongs to the urease beta subunit family
URS_RS09700	COG0804	urea catabolic process
URS_RS09705	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
URS_RS09710	COG0830	nickel cation binding
URS_RS09715	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
URS_RS09740	COG0742	ribosomal rna small subunit methyltransferase
URS_RS09745	COG0768	penicillin binding
URS_RS09760	COG0563	adenylate kinase activity
URS_RS09770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
URS_RS09775	COG2878	Part of a membrane complex involved in electron transport
URS_RS09780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
URS_RS09790	COG3384	dioxygenase
URS_RS09805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
URS_RS09835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_RS09845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
URS_RS09855	COG1671	Belongs to the UPF0178 family
URS_RS09875	COG1136	(ABC) transporter
URS_RS09880	COG2333	competence protein COMEC
URS_RS09880	COG0658	competence protein
URS_RS09900	COG1113	amino acid transport
URS_RS09905	COG2828	Protein conserved in bacteria
URS_RS09915	COG0142	geranyltranstransferase activity
URS_RS09930	COG1752	Esterase of the alpha-beta hydrolase superfamily
URS_RS09940	COG2814	Major facilitator Superfamily
URS_RS09945	COG0745	RESPONSE REGULATOR receiver
URS_RS09960	COG0004	ammonium transporteR
URS_RS09975	COG0525	valine-tRNA ligase activity
URS_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS09990	COG0393	Putative heavy-metal-binding
URS_RS09995	COG0393	Putative heavy-metal-binding
URS_RS10000	COG1538	Outer membrane efflux protein
URS_RS10010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_RS10015	COG0671	phosphoesterase, PA-phosphatase related
URS_RS10030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
URS_RS10035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
URS_RS10045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
URS_RS10055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
URS_RS10060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
URS_RS10060	COG1648	precorrin-2 dehydrogenase activity
URS_RS10065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
URS_RS10075	COG1733	regulation of RNA biosynthetic process
URS_RS10120	COG0583	DNA-binding transcription factor activity
URS_RS10130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_RS10135	COG1773	rubredoxin
URS_RS10140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
URS_RS10155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
URS_RS10175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
URS_RS10175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
URS_RS10190	COG0523	cobalamin synthesis protein
URS_RS10200	COG4681	YaeQ
URS_RS10220	COG1649	PFAM Uncharacterised BCR, COG1649
URS_RS10220	COG0726	polysaccharide deacetylase
URS_RS10225	COG1215	transferase activity, transferring glycosyl groups
URS_RS10250	COG0400	carboxylic ester hydrolase activity
URS_RS10265	COG0561	phosphatase activity
URS_RS10270	COG0242	peptide deformylase activity
URS_RS10275	COG2066	Belongs to the glutaminase family
URS_RS10285	COG2223	nitrite transmembrane transporter activity
URS_RS10295	COG3293	Transposase
URS_RS10305	COG2852	Protein conserved in bacteria
URS_RS10315	COG0653	protein targeting
URS_RS10325	COG0306	phosphate transporter
URS_RS10345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
URS_RS10365	COG4771	TonB-dependent receptor
URS_RS10370	COG4771	TonB-dependent receptor
URS_RS10385	COG0288	reversible hydration of carbon dioxide
URS_RS10395	COG4181	ATPase activity
URS_RS10400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
URS_RS10410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
URS_RS10420	COG0589	response to stress
URS_RS10430	COG0589	response to stress
URS_RS10450	COG0505	Belongs to the CarA family
URS_RS10470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
URS_RS10475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
URS_RS10480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
URS_RS10500	COG1929	Belongs to the glycerate kinase type-1 family
URS_RS10520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
URS_RS10545	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
URS_RS10550	COG1597	lipid kinase activity
URS_RS10560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
URS_RS10565	COG0459	protein refolding
URS_RS10570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
URS_RS10575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
URS_RS10580	COG1045	serine acetyltransferase
URS_RS10590	COG2188	Transcriptional regulator
URS_RS10595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
URS_RS10620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
URS_RS10625	COG2239	Acts as a magnesium transporter
URS_RS10635	COG0501	Belongs to the peptidase M48B family
URS_RS10640	COG0739	heme binding
URS_RS10640	COG0741	lytic transglycosylase activity
URS_RS10640	COG1196	nuclear chromosome segregation
URS_RS10645	COG0037	tRNA processing
URS_RS10655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
URS_RS10660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
URS_RS10670	COG0583	DNA-binding transcription factor activity
URS_RS10685	COG1131	(ABC) transporter
URS_RS10690	COG0842	Transport permease protein
URS_RS10695	COG0842	Transport permease protein
URS_RS10705	COG0583	DNA-binding transcription factor activity
URS_RS10710	COG0473	3-isopropylmalate dehydrogenase activity
URS_RS10720	COG0657	acetylesterase activity
URS_RS10725	COG4638	Rieske (2fe-2S)
URS_RS10730	COG1012	belongs to the aldehyde dehydrogenase family
URS_RS10745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
URS_RS10745	COG0475	glutathione-regulated potassium exporter activity
URS_RS10755	COG1203	CRISPR-associated helicase, Cas3
URS_RS10775	COG2826	transposase and inactivated derivatives, IS30 family
URS_RS10785	COG3421	Type III restriction
URS_RS10790	COG2189	Belongs to the N(4) N(6)-methyltransferase family
URS_RS10830	COG1741	Belongs to the pirin family
URS_RS10840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
URS_RS10845	COG3739	integral membrane protein
URS_RS10855	COG0586	Pfam SNARE associated Golgi protein
URS_RS10860	COG0302	gtp cyclohydrolase
URS_RS10870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
URS_RS10875	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
URS_RS10875	COG3608	succinylglutamate desuccinylase aspartoacylase
URS_RS10890	COG2826	transposase and inactivated derivatives, IS30 family
URS_RS10900	COG0134	indole-3-glycerol-phosphate synthase activity
URS_RS10905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
URS_RS10910	COG0512	Glutamine amidotransferase of anthranilate synthase
URS_RS10915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
URS_RS10920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
URS_RS10925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
URS_RS10930	COG1067	ATP-dependent peptidase activity
URS_RS10945	COG0254	rRNA binding
URS_RS10950	COG0583	DNA-binding transcription factor activity
URS_RS10955	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
URS_RS10960	COG4208	sulfate ABC transporter
URS_RS10965	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
URS_RS10975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
URS_RS10980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
URS_RS10985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
URS_RS10990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
URS_RS11000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
URS_RS11005	COG0174	glutamine synthetase
URS_RS11015	COG0481	GTPase activity
URS_RS11020	COG0681	Belongs to the peptidase S26 family
URS_RS11030	COG0571	ribonuclease III activity
URS_RS11035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
URS_RS11045	COG1381	Involved in DNA repair and RecF pathway recombination
URS_RS11050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
URS_RS11070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
URS_RS11080	COG1301	dicarboxylic acid transport
URS_RS11100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
URS_RS11105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
URS_RS11130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
URS_RS11135	COG0826	peptidase U32
URS_RS11140	COG3384	dioxygenase
URS_RS11145	COG1335	isochorismatase
URS_RS11160	COG1720	tRNA m6t6A37 methyltransferase activity
URS_RS11165	COG3706	GGDEF domain
URS_RS11170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
URS_RS11175	COG3111	PFAM Bacterial OB fold (BOF) protein
URS_RS11185	COG0642	Histidine kinase
URS_RS11195	COG0494	nUDIX hydrolase
URS_RS11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
URS_RS11210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
URS_RS11215	COG3139	Protein of unknown function (DUF1315)
URS_RS11220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
URS_RS11225	COG1301	dicarboxylic acid transport
URS_RS11235	COG0659	secondary active sulfate transmembrane transporter activity
URS_RS11240	COG2252	PERMEase
URS_RS11245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
URS_RS11260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
URS_RS11275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
URS_RS11290	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
URS_RS11295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
URS_RS11310	COG0667	Aldo Keto reductase
URS_RS11320	COG1765	OsmC-like protein
URS_RS11345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
URS_RS11345	COG0116	Belongs to the methyltransferase superfamily
URS_RS11350	COG0540	Belongs to the ATCase OTCase family
URS_RS11380	COG2995	paraquat-inducible protein a
URS_RS11385	COG3008	intermembrane lipid transfer
URS_RS11385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
URS_RS11395	COG0047	phosphoribosylformylglycinamidine synthase activity
URS_RS11395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
URS_RS11415	COG1024	Enoyl-CoA hydratase
URS_RS11420	COG1056	cytidyltransferase-related domain
URS_RS11420	COG1051	belongs to the nudix hydrolase family
URS_RS11425	COG2353	YceI-like domain
URS_RS11430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
URS_RS11440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
URS_RS11445	COG0602	queuosine metabolic process
URS_RS11455	COG4625	pathogenesis
URS_RS11470	COG1509	lysine 2,3-aminomutase activity
URS_RS11475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
URS_RS11480	COG1966	Carbon starvation protein
URS_RS11485	COG2879	small protein
URS_RS11490	COG0714	Associated with various cellular activities
URS_RS11500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_RS11510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_RS11520	COG0596	Alpha beta hydrolase
URS_RS11525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
URS_RS11550	COG3706	GGDEF domain
URS_RS11590	COG0436	Aminotransferase
URS_RS11595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
URS_RS11600	COG0386	Belongs to the glutathione peroxidase family
URS_RS11630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
URS_RS11635	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
URS_RS11655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
URS_RS11660	COG0012	GTP binding
URS_RS11665	COG2011	ABC-type metal ion transport system permease component
URS_RS11670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
URS_RS11675	COG1464	Belongs to the NlpA lipoprotein family
URS_RS11700	COG2826	transposase and inactivated derivatives, IS30 family
URS_RS11710	COG0471	metal ion transport
URS_RS11715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
URS_RS11720	COG2814	Major facilitator Superfamily
URS_RS11730	COG0583	DNA-binding transcription factor activity
URS_RS11740	COG2707	UPF0756 membrane protein
URS_RS11750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
URS_RS11775	COG2826	transposase and inactivated derivatives, IS30 family
URS_RS11800	COG0564	pseudouridine synthase activity
URS_RS11805	COG0802	atpase or kinase
URS_RS11810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
URS_RS11815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
URS_RS11820	COG1923	regulation of RNA biosynthetic process
URS_RS11825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
URS_RS11830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
URS_RS11840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
URS_RS11845	COG0357	Ribosomal RNA small subunit methyltransferase G
URS_RS11850	COG1192	Involved in chromosome partitioning
URS_RS11855	COG1475	DNA binding
URS_RS11860	COG0811	peptide transport
URS_RS11870	COG1132	(ABC) transporter
URS_RS11875	COG1663	tetraacyldisaccharide 4'-kinase activity
URS_RS11895	COG0084	hydrolase, TatD family'
URS_RS11950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
URS_RS11960	COG0776	regulation of translation
URS_RS11975	COG0284	orotidine-5'-phosphate decarboxylase activity
URS_RS11995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
URS_RS12015	COG1253	flavin adenine dinucleotide binding
URS_RS12030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
URS_RS12040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
URS_RS12045	COG0730	response to heat
URS_RS12065	COG4773	Receptor
URS_RS12070	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
URS_RS12105	COG2815	serine threonine protein kinase
URS_RS12105	COG0515	serine threonine protein kinase
URS_RS12145	COG2011	ABC-type metal ion transport system permease component
URS_RS12150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
URS_RS12155	COG1464	Belongs to the NlpA lipoprotein family
URS_RS12165	COG0138	bifunctional purine biosynthesis protein purh
URS_RS12170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
URS_RS12195	COG0445	tRNA wobble uridine modification
URS_RS12205	COG2308	Evidence 4 Homologs of previously reported genes of
URS_RS12215	COG1305	Transglutaminase-like
URS_RS12230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
URS_RS12235	COG0305	Participates in initiation and elongation during chromosome replication
URS_RS12240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
URS_RS12240	COG0517	IMP dehydrogenase activity
URS_RS12275	COG0552	protein localization to endoplasmic reticulum
URS_RS12295	COG4890	Cyd operon protein YbgT
URS_RS12300	COG1294	oxidase, subunit
URS_RS12315	COG1585	Membrane protein implicated in regulation of membrane protease activity
URS_RS12325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
URS_RS12340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
URS_RS12345	COG0569	domain protein
URS_RS12350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
URS_RS12355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
URS_RS12370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
URS_RS12380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
URS_RS12385	COG0542	response to heat
URS_RS12410	COG0765	amino acid transport
URS_RS12415	COG0765	amino acid transport
URS_RS12420	COG1126	abc transporter atp-binding protein
URS_RS12435	COG0217	transcriptional regulatory protein
URS_RS12445	COG4774	siderophore transport
URS_RS12450	COG2193	ferroxidase activity
URS_RS12540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
URS_RS12550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
URS_RS12550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
URS_RS12580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
URS_RS12585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
URS_RS12600	COG2353	YceI-like domain
URS_RS12610	COG0505	Belongs to the CarA family
URS_RS12630	COG1454	alcohol dehydrogenase
URS_RS12635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
URS_RS12645	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
URS_RS12650	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
URS_RS12665	COG0308	aminopeptidase N
URS_RS12675	COG0589	response to stress
URS_RS12690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
URS_RS12700	COG3135	benzoate transporter
URS_RS12710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
URS_RS12740	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS12745	COG2030	dehydratase
URS_RS12750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
URS_RS12775	COG0824	Thioesterase
URS_RS12780	COG1454	alcohol dehydrogenase
URS_RS12785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
URS_RS12790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
URS_RS12840	COG0316	Belongs to the HesB IscA family
URS_RS12845	COG0822	iron-sulfur transferase activity
URS_RS12875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
URS_RS12880	COG2814	Major facilitator Superfamily
URS_RS12940	COG0024	Methionine aminopeptidase
URS_RS12945	COG0583	DNA-binding transcription factor activity
URS_RS12950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
URS_RS12960	COG0583	DNA-binding transcription factor activity
URS_RS12965	COG1960	acyl-CoA dehydrogenase activity
URS_RS12970	COG2814	Major facilitator Superfamily
URS_RS12975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
URS_RS13010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
URS_RS13020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
URS_RS13030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
URS_RS13045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
URS_RS13060	COG1346	cytolysis
URS_RS13065	COG1380	Effector of murein hydrolase LrgA
URS_RS13070	COG0583	DNA-binding transcription factor activity
URS_RS13110	COG0644	oxidoreductase
URS_RS13110	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
URS_RS13140	COG2814	Major facilitator Superfamily
URS_RS13155	COG0183	Belongs to the thiolase family
URS_RS13160	COG1250	3-hydroxyacyl-CoA dehydrogenase
URS_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
URS_RS13170	COG1024	Enoyl-CoA hydratase
URS_RS13175	COG1960	acyl-CoA dehydrogenase activity
URS_RS13180	COG2814	Major facilitator Superfamily
URS_RS13185	COG2814	Major facilitator Superfamily
URS_RS13195	COG3328	transposase activity
URS_RS13205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
URS_RS13215	COG2814	Major facilitator Superfamily
URS_RS13225	COG1960	acyl-CoA dehydrogenase activity
URS_RS13230	COG1024	Enoyl-CoA hydratase
URS_RS13235	COG0235	Class ii aldolase
URS_RS13240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
URS_RS13245	COG0583	DNA-binding transcription factor activity
URS_RS13250	COG0477	Major facilitator Superfamily
URS_RS13255	COG1414	Transcriptional regulator
URS_RS13260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
URS_RS13265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
URS_RS13270	COG0183	Belongs to the thiolase family
URS_RS13275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
URS_RS13280	COG0596	Alpha beta hydrolase
URS_RS13285	COG2271	Major facilitator Superfamily
URS_RS13290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
URS_RS13295	COG3485	protocatechuate 3,4-dioxygenase
URS_RS13300	COG3485	protocatechuate 3,4-dioxygenase
URS_RS13305	COG0710	3-dehydroquinate dehydratase activity
URS_RS13310	COG3420	alginic acid biosynthetic process
URS_RS13390	COG1846	Transcriptional regulator
URS_RS13395	COG0583	DNA-binding transcription factor activity
URS_RS13400	COG1027	Aspartate ammonia-lyase
URS_RS13445	COG0640	Transcriptional regulator
URS_RS13460	COG3122	Protein conserved in bacteria
URS_RS13465	COG0668	transmembrane transport
URS_RS13470	COG1132	(ABC) transporter
URS_RS13485	COG0509	glycine decarboxylation via glycine cleavage system
URS_RS13490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
URS_RS13500	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
URS_RS13510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
URS_RS13555	COG1960	acyl-CoA dehydrogenase activity
URS_RS13570	COG2826	transposase and inactivated derivatives, IS30 family
URS_RS13595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
URS_RS13600	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
URS_RS13620	COG0697	spore germination
URS_RS13625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_RS13635	COG0725	ABC transporter, periplasmic molybdate-binding protein
URS_RS13640	COG0303	'Molybdopterin
URS_RS13645	COG0521	Mo-molybdopterin cofactor biosynthetic process
URS_RS13645	COG0315	cyclic pyranopterin monophosphate synthase activity
URS_RS13670	COG0243	molybdopterin cofactor binding
URS_RS13675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_RS13680	COG2146	nitrite reductase [NAD(P)H] activity
URS_RS13680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_RS13685	COG2223	nitrite transmembrane transporter activity
URS_RS13690	COG0745	RESPONSE REGULATOR receiver
URS_RS13695	COG1116	anion transmembrane transporter activity
URS_RS13695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_RS13705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_RS13710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
URS_RS13720	COG0148	phosphopyruvate hydratase activity
URS_RS13730	COG0504	CTP synthase activity
URS_RS13750	COG0446	pyridine nucleotide-disulphide oxidoreductase
URS_RS13750	COG1902	pentaerythritol trinitrate reductase activity
URS_RS13760	COG2267	carboxylic ester hydrolase activity
URS_RS13765	COG0477	Major facilitator Superfamily
URS_RS13770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
URS_RS13775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
URS_RS13785	COG0506	proline dehydrogenase activity
URS_RS13785	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
URS_RS13785	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
URS_RS13790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
URS_RS13795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
URS_RS13805	COG3698	Phosphodiester glycosidase
URS_RS13845	COG0697	spore germination
URS_RS13850	COG0191	fructose-bisphosphate aldolase activity
URS_RS13860	COG0126	phosphoglycerate kinase activity
URS_RS13870	COG0424	maF-like protein
URS_RS13880	COG2850	peptidyl-arginine hydroxylation
URS_RS13885	COG0069	glutamate synthase activity
URS_RS13900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
URS_RS13905	COG0702	epimerase
URS_RS13910	COG0268	Binds directly to 16S ribosomal RNA
URS_RS13915	COG3594	Acyltransferase
URS_RS13925	COG1218	3'(2'),5'-bisphosphate nucleotidase
URS_RS13930	COG1011	Hydrolase
URS_RS13935	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
URS_RS13945	COG2137	regulation of response to DNA damage stimulus
URS_RS13960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
URS_RS13970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
URS_RS13995	COG0575	Belongs to the CDS family
URS_RS14000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
URS_RS14005	COG0233	cytoplasmic translational termination
URS_RS14010	COG0528	UMP kinase activity
URS_RS14020	COG3852	Histidine kinase
URS_RS14025	COG2204	response regulator
URS_RS14035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
URS_RS14055	COG2963	transposase activity
URS_RS14060	COG3328	transposase activity
URS_RS14105	COG0729	surface antigen
URS_RS14115	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
URS_RS14125	COG0745	RESPONSE REGULATOR receiver
URS_RS14130	COG2205	protein histidine kinase activity
URS_RS14140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
URS_RS14145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
URS_RS14155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
URS_RS14180	COG1960	acyl-CoA dehydrogenase activity
URS_RS14185	COG1960	acyl-CoA dehydrogenase activity
URS_RS14195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
URS_RS14200	COG2207	Transcriptional regulator
URS_RS14225	COG1968	undecaprenyl-diphosphatase activity
URS_RS14230	COG3042	response to heat
URS_RS14265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_RS14270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
URS_RS14285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_RS14295	COG2890	protein-(glutamine-N5) methyltransferase activity
URS_RS14300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
URS_RS14310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_RS14315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
URS_RS14330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
URS_RS14335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
URS_RS14340	COG1845	cytochrome c oxidase, subunit III
URS_RS14345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
URS_RS14355	COG0360	Binds together with S18 to 16S ribosomal RNA
URS_RS14360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
URS_RS14375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
URS_RS14385	COG3100	YcgL domain-containing protein
URS_RS14395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
URS_RS14425	COG0537	adenosine 5'-monophosphoramidase activity
URS_RS14445	COG1610	YqeY-like protein
URS_RS14480	COG1286	toxin biosynthetic process
URS_RS14485	COG0167	dihydroorotate dehydrogenase activity
URS_RS14510	COG0778	Nitroreductase
URS_RS14520	COG0513	Belongs to the DEAD box helicase family
URS_RS14560	COG0625	glutathione transferase activity
URS_RS14585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
URS_RS14590	COG1960	acyl-CoA dehydrogenase activity
URS_RS14600	COG3706	GGDEF domain
URS_RS14610	COG4716	Myosin-crossreactive antigen
URS_RS14625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
URS_RS14630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
URS_RS14635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
URS_RS14655	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
URS_RS14660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
URS_RS14665	COG0583	DNA-binding transcription factor activity
URS_RS14675	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
URS_RS14690	COG1686	Belongs to the peptidase S11 family
URS_RS14695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
URS_RS14710	COG0482	sulfurtransferase activity
URS_RS14715	COG2915	High frequency lysogenization protein hflD homolog
URS_RS14730	COG0616	signal peptide processing
URS_RS14735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
URS_RS14745	COG0573	inorganic phosphate transmembrane transporter activity
URS_RS14750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
URS_RS14755	COG0076	glutamate decarboxylase activity
URS_RS14760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
URS_RS14780	COG1309	transcriptional regulator
URS_RS14785	COG0783	Belongs to the Dps family
URS_RS14795	COG0564	pseudouridine synthase activity
URS_RS14800	COG3193	protein, possibly involved in utilization of glycolate and propanediol
URS_RS14810	COG0352	thiamine-phosphate diphosphorylase activity
URS_RS14820	COG1686	Belongs to the peptidase S11 family
URS_RS14830	COG0589	response to stress
URS_RS14845	COG0671	phosphoesterase, PA-phosphatase related
URS_RS14855	COG2194	sulfuric ester hydrolase activity
URS_RS14860	COG0745	RESPONSE REGULATOR receiver
URS_RS14880	COG3328	transposase activity
URS_RS14930	COG1401	restriction endodeoxyribonuclease activity
URS_RS14935	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
URS_RS14935	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
URS_RS14945	COG3586	endonuclease activity
URS_RS15050	COG0582	viral genome integration into host DNA
URS_RS15060	COG1131	(ABC) transporter
URS_RS15065	COG0842	Transport permease protein
URS_RS15070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
URS_RS15070	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
URS_RS15080	COG0772	Belongs to the SEDS family
URS_RS15085	COG2951	lytic endotransglycosylase activity
URS_RS15120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
URS_RS15125	COG0052	Belongs to the universal ribosomal protein uS2 family
URS_RS15130	COG0024	Methionine aminopeptidase
URS_RS15145	COG2175	clavaminate synthase activity
URS_RS15155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
URS_RS15170	COG4372	Transposase
URS_RS15190	COG4969	Belongs to the N-Me-Phe pilin family
URS_RS15215	COG4968	Prepilin-type N-terminal cleavage methylation domain
URS_RS15225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
URS_RS15230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
URS_RS15240	COG4122	O-methyltransferase activity
URS_RS15270	COG1538	Outer membrane efflux protein
URS_RS15290	COG1137	ATPase activity
URS_RS15295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
URS_RS15305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
URS_RS15325	COG4993	Dehydrogenase
URS_RS15330	COG2175	clavaminate synthase activity
URS_RS15335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_RS15340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
URS_RS15345	COG4521	taurine ABC transporter
URS_RS15360	COG2255	four-way junction helicase activity
URS_RS15365	COG0824	Thioesterase
URS_RS15385	COG0823	Involved in the tonB-independent uptake of proteins
URS_RS15405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
URS_RS15425	COG3706	GGDEF domain
URS_RS15425	COG5001	Diguanylate cyclase
URS_RS15425	COG4251	negative regulation of phosphorylation
URS_RS15425	COG2203	Gaf domain
URS_RS15430	COG0418	dihydroorotase activity
URS_RS15435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
URS_RS15445	COG0833	amino acid
URS_RS15455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
URS_RS15460	COG0243	molybdopterin cofactor binding
URS_RS15470	COG1643	Atp-dependent helicase
URS_RS15515	COG3022	response to hydroperoxide
URS_RS15520	COG2195	Cleaves the N-terminal amino acid of tripeptides
URS_RS15530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
URS_RS15550	COG1960	acyl-CoA dehydrogenase activity
URS_RS15565	COG2015	COG2015, Alkyl sulfatase and related hydrolases
URS_RS15580	COG2985	domain, Protein
URS_RS15585	COG1764	response to oxidative stress
URS_RS15610	COG0632	four-way junction helicase activity
URS_RS15615	COG4302	ethanolamine ammonia-lyase activity
URS_RS15620	COG4303	Ethanolamine ammonia lyase large subunit
URS_RS15625	COG0531	amino acid
URS_RS15630	COG2070	2-Nitropropane dioxygenase
URS_RS15640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
URS_RS15655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
URS_RS15680	COG2962	Rard protein
URS_RS15685	COG3040	lipid binding
URS_RS15690	COG0556	nucleotide-excision repair
URS_RS15705	COG0257	Belongs to the bacterial ribosomal protein bL36 family
URS_RS15715	COG0436	Aminotransferase
URS_RS15730	COG0174	glutamine synthetase
URS_RS15770	COG1802	Transcriptional regulator
URS_RS15790	COG1522	sequence-specific DNA binding
URS_RS15840	COG0612	Peptidase, M16
URS_RS15845	COG0038	chloride channel
URS_RS15850	COG0384	phenazine biosynthesis protein PhzF
URS_RS15855	COG1823	symporter activity
URS_RS15865	COG1187	pseudouridine synthase activity
URS_RS15875	COG2351	hydroxyisourate hydrolase activity
URS_RS15895	COG4172	Belongs to the ABC transporter superfamily
URS_RS15900	COG4239	(ABC) transporter, permease
URS_RS15905	COG4174	ABC transporter (Permease)
URS_RS15910	COG4166	transmembrane transport
URS_RS15915	COG0741	lytic transglycosylase activity
URS_RS15915	COG1388	LysM domain
URS_RS15915	COG0741	lytic transglycosylase activity
URS_RS15915	COG1388	LysM domain
URS_RS15920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
URS_RS15945	COG0792	nuclease activity
URS_RS15950	COG3107	peptidoglycan biosynthetic process
URS_RS15965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_RS15970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_RS15975	COG0006	proline dipeptidase activity
URS_RS15980	COG3079	Belongs to the UPF0149 family
URS_RS16105	COG0640	Transcriptional regulator
URS_RS16115	COG0798	PFAM Bile acid sodium symporter
URS_RS16120	COG0431	NADPH-dependent FMN reductase
URS_RS16125	COG0492	ferredoxin-NADP+ reductase activity
URS_RS16150	COG0583	DNA-binding transcription factor activity
URS_RS16160	COG2233	PERMEase
URS_RS16180	COG0583	DNA-binding transcription factor activity
URS_RS16280	COG2132	Multicopper oxidase
URS_RS16320	COG3264	Mechanosensitive ion channel
URS_RS16320	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
URS_RS16345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
URS_RS16350	COG0501	Belongs to the peptidase M48B family
URS_RS16385	COG0542	response to heat
URS_RS16405	COG2072	flavoprotein involved in K transport
URS_RS16415	COG2144	transferase activity, transferring acyl groups
URS_RS16440	COG3604	Transcriptional regulator
URS_RS16475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_RS16485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_RS16490	COG1113	amino acid transport
URS_RS16495	COG0697	spore germination
URS_RS16500	COG0582	viral genome integration into host DNA
URS_RS16505	COG2369	cell adhesion
URS_RS16530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
URS_RS16615	COG1785	Belongs to the alkaline phosphatase family
URS_RS16630	COG1192	Involved in chromosome partitioning
URS_RS16650	COG1595	DNA-templated transcription, initiation
URS_RS16660	COG3220	belongs to the UPF0276 family
URS_RS16715	COG1979	alcohol dehydrogenase
URS_RS16730	COG1012	belongs to the aldehyde dehydrogenase family
URS_RS16735	COG1902	pentaerythritol trinitrate reductase activity
URS_RS16745	COG1309	transcriptional regulator
URS_RS16750	COG2130	NADP-dependent
URS_RS16760	COG1764	response to oxidative stress
URS_RS16765	COG1846	Transcriptional regulator