locus-tag	class	description
LSO58_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LSO58_RS00010	COG0592	DNA-directed DNA polymerase activity
LSO58_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LSO58_RS00020	COG0187	DNA topoisomerase II activity
LSO58_RS00030	COG0488	(ABC) transporter
LSO58_RS00050	COG0316	Belongs to the HesB IscA family
LSO58_RS00055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LSO58_RS00060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LSO58_RS00090	COG0693	protein deglycase activity
LSO58_RS00105	COG1012	belongs to the aldehyde dehydrogenase family
LSO58_RS00110	COG0733	neurotransmitter:sodium symporter activity
LSO58_RS00120	COG0428	transporter
LSO58_RS00125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LSO58_RS00130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LSO58_RS00145	COG1252	NADH dehydrogenase
LSO58_RS00150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSO58_RS00165	COG2233	PERMEase
LSO58_RS00170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LSO58_RS00175	COG1309	transcriptional regulator
LSO58_RS00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO58_RS00195	COG0484	heat shock protein binding
LSO58_RS00200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LSO58_RS00210	COG2814	Major facilitator Superfamily
LSO58_RS00215	COG0583	DNA-binding transcription factor activity
LSO58_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO58_RS00230	COG1064	alcohol dehydrogenase
LSO58_RS00235	COG2818	Glycosylase
LSO58_RS00250	COG1194	a g-specific adenine glycosylase
LSO58_RS00260	COG0412	Dienelactone hydrolase
LSO58_RS00265	COG5487	UPF0391 membrane protein
LSO58_RS00270	COG2983	Belongs to the UPF0260 family
LSO58_RS00285	COG2133	pyrroloquinoline quinone binding
LSO58_RS00295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LSO58_RS00300	COG2116	formate transmembrane transporter activity
LSO58_RS00310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LSO58_RS00320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LSO58_RS00325	COG1335	isochorismatase
LSO58_RS00330	COG0385	Bile acid
LSO58_RS00335	COG2388	GCN5-related N-acetyl-transferase
LSO58_RS00355	COG3188	usher protein
LSO58_RS00365	COG3121	Chaperone
LSO58_RS00380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LSO58_RS00390	COG1061	Type III restriction enzyme res subunit
LSO58_RS00395	COG1002	Type II restriction enzyme, methylase subunits
LSO58_RS00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LSO58_RS00450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LSO58_RS00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LSO58_RS00460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LSO58_RS00465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LSO58_RS00480	COG0560	Phosphoserine phosphatase
LSO58_RS00480	COG3830	Belongs to the UPF0237 family
LSO58_RS00500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LSO58_RS00510	COG0688	phosphatidylethanolamine metabolic process
LSO58_RS00520	COG0300	oxidoreductase activity
LSO58_RS00550	COG0534	Mate efflux family protein
LSO58_RS00555	COG0436	Aminotransferase
LSO58_RS00560	COG2733	membrane
LSO58_RS00575	COG2918	glutathione biosynthetic process
LSO58_RS00580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LSO58_RS00590	COG3150	esterase
LSO58_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LSO58_RS00615	COG4266	Belongs to the allantoicase family
LSO58_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO58_RS00630	COG1247	-acetyltransferase
LSO58_RS00675	COG0625	glutathione transferase activity
LSO58_RS00680	COG3706	GGDEF domain
LSO58_RS00695	COG1393	Belongs to the ArsC family
LSO58_RS00700	COG0708	Exodeoxyribonuclease III
LSO58_RS00720	COG0189	ligase activity
LSO58_RS00725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LSO58_RS00735	COG1181	Belongs to the D-alanine--D-alanine ligase family
LSO58_RS00740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LSO58_RS00750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LSO58_RS00785	COG2119	membrane
LSO58_RS00790	COG0426	domain, Protein
LSO58_RS00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO58_RS00810	COG0259	pyridoxamine-phosphate oxidase activity
LSO58_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LSO58_RS00820	COG1476	TRANSCRIPTIONal
LSO58_RS00845	COG1902	pentaerythritol trinitrate reductase activity
LSO58_RS00855	COG1519	Transferase
LSO58_RS00865	COG0668	transmembrane transport
LSO58_RS00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LSO58_RS00905	COG0004	ammonium transporteR
LSO58_RS00920	COG2205	protein histidine kinase activity
LSO58_RS00920	COG0784	Response regulator, receiver
LSO58_RS00925	COG3162	membrane
LSO58_RS00930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSO58_RS00945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LSO58_RS00965	COG2801	Transposase and inactivated derivatives
LSO58_RS00970	COG1733	regulation of RNA biosynthetic process
LSO58_RS00980	COG2249	NAD(P)H dehydrogenase (quinone) activity
LSO58_RS00995	COG4628	conserved protein (DUF2132)
LSO58_RS01020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LSO58_RS01025	COG3550	peptidyl-serine autophosphorylation
LSO58_RS01070	COG1538	Outer membrane efflux protein
LSO58_RS01075	COG1132	(ABC) transporter
LSO58_RS01100	COG0753	catalase activity
LSO58_RS01115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO58_RS01125	COG3756	Protein conserved in bacteria
LSO58_RS01170	COG1192	Involved in chromosome partitioning
LSO58_RS01185	COG0586	Pfam SNARE associated Golgi protein
LSO58_RS01190	COG2259	Doxx family
LSO58_RS01195	COG3111	PFAM Bacterial OB fold (BOF) protein
LSO58_RS01200	COG0519	Catalyzes the synthesis of GMP from XMP
LSO58_RS01200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LSO58_RS01260	COG0281	malic enzyme
LSO58_RS01270	COG0791	NLP P60 protein
LSO58_RS01270	COG1388	LysM domain
LSO58_RS01280	COG1280	lysine exporter protein (LysE YggA)
LSO58_RS01285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LSO58_RS01290	COG1121	(ABC) transporter
LSO58_RS01310	COG0356	it plays a direct role in the translocation of protons across the membrane
LSO58_RS01340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LSO58_RS01345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LSO58_RS01370	COG0386	Belongs to the glutathione peroxidase family
LSO58_RS01380	COG2814	Major facilitator Superfamily
LSO58_RS01385	COG1309	transcriptional regulator
LSO58_RS01390	COG0697	spore germination
LSO58_RS01430	COG3845	ABC transporter
LSO58_RS01435	COG4603	Belongs to the binding-protein-dependent transport system permease family
LSO58_RS01440	COG1079	Belongs to the binding-protein-dependent transport system permease family
LSO58_RS01445	COG0009	L-threonylcarbamoyladenylate synthase
LSO58_RS01450	COG0758	DNA mediated transformation
LSO58_RS01455	COG1652	LysM domain
LSO58_RS01485	COG1309	transcriptional regulator
LSO58_RS01535	COG0477	Major facilitator Superfamily
LSO58_RS01540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LSO58_RS01560	COG1253	flavin adenine dinucleotide binding
LSO58_RS01570	COG2860	membrane
LSO58_RS01580	COG0477	Major facilitator Superfamily
LSO58_RS01590	COG0318	PFAM AMP-dependent synthetase and ligase
LSO58_RS01605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LSO58_RS01630	COG0347	Belongs to the P(II) protein family
LSO58_RS01635	COG0004	ammonium transporteR
LSO58_RS01645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LSO58_RS01645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LSO58_RS01680	COG0795	lipopolysaccharide-transporting ATPase activity
LSO58_RS01685	COG0795	lipopolysaccharide-transporting ATPase activity
LSO58_RS01690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LSO58_RS01695	COG0793	Belongs to the peptidase S41A family
LSO58_RS01710	COG2197	response regulator
LSO58_RS01720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LSO58_RS01730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LSO58_RS01735	COG4974	Belongs to the 'phage' integrase family
LSO58_RS01755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LSO58_RS01760	COG0772	Belongs to the SEDS family
LSO58_RS01765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LSO58_RS01770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LSO58_RS01775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LSO58_RS01780	COG0494	nUDIX hydrolase
LSO58_RS01810	COG3275	phosphorelay sensor kinase activity
LSO58_RS01820	COG0181	hydroxymethylbilane synthase activity
LSO58_RS01865	COG1716	ATPase activity
LSO58_RS01900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LSO58_RS01920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LSO58_RS01925	COG0081	regulation of translation
LSO58_RS01940	COG0085	RNA polymerase activity
LSO58_RS01945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LSO58_RS01980	COG0326	Molecular chaperone. Has ATPase activity
LSO58_RS02010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LSO58_RS02035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LSO58_RS02040	COG1758	RNA polymerase activity
LSO58_RS02045	COG0194	GDP metabolic process
LSO58_RS02090	COG0228	four-way junction DNA binding
LSO58_RS02095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LSO58_RS02105	COG0335	large ribosomal subunit rRNA binding
LSO58_RS02110	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LSO58_RS02115	COG5380	lipid catabolic process
LSO58_RS02120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LSO58_RS02140	COG5006	permease, DMT superfamily
LSO58_RS02145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LSO58_RS02150	COG0277	FAD linked oxidase domain protein
LSO58_RS02170	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LSO58_RS02175	COG2249	NAD(P)H dehydrogenase (quinone) activity
LSO58_RS02190	COG0628	permease
LSO58_RS02195	COG1192	Involved in chromosome partitioning
LSO58_RS02240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LSO58_RS02255	COG0583	DNA-binding transcription factor activity
LSO58_RS02275	COG0752	glycyl-tRNA synthetase alpha subunit
LSO58_RS02290	COG0517	IMP dehydrogenase activity
LSO58_RS02295	COG1983	PspC domain protein
LSO58_RS02305	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS02320	COG2885	chlorophyll binding
LSO58_RS02330	COG0408	coproporphyrinogen oxidase activity
LSO58_RS02335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LSO58_RS02340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LSO58_RS02360	COG0513	Belongs to the DEAD box helicase family
LSO58_RS02370	COG1127	ABC transporter
LSO58_RS02375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LSO58_RS02395	COG0598	Magnesium transport protein CorA
LSO58_RS02405	COG0494	nUDIX hydrolase
LSO58_RS02410	COG1040	competence protein
LSO58_RS02415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LSO58_RS02430	COG2937	Belongs to the GPAT DAPAT family
LSO58_RS02435	COG1946	Acyl-CoA thioesterase
LSO58_RS02440	COG1301	dicarboxylic acid transport
LSO58_RS02455	COG1959	2 iron, 2 sulfur cluster binding
LSO58_RS02460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSO58_RS02460	COG1017	nitric oxide dioxygenase activity
LSO58_RS02465	COG0433	COG0433 Predicted ATPase
LSO58_RS02480	COG0051	transcription antitermination factor activity, RNA binding
LSO58_RS02485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LSO58_RS02490	COG0088	Forms part of the polypeptide exit tunnel
LSO58_RS02505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LSO58_RS02510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LSO58_RS02520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LSO58_RS02530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LSO58_RS02535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LSO58_RS02540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LSO58_RS02545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LSO58_RS02555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LSO58_RS02560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LSO58_RS02570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LSO58_RS02595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LSO58_RS02605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LSO58_RS02610	COG0202	RNA polymerase activity
LSO58_RS02615	COG0203	ribosomal protein L17
LSO58_RS02620	COG2072	flavoprotein involved in K transport
LSO58_RS02625	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS02630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LSO58_RS02660	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LSO58_RS02665	COG0339	signal peptide processing
LSO58_RS02675	COG0557	exoribonuclease II activity
LSO58_RS02720	COG0179	Fumarylacetoacetate (FAA) hydrolase
LSO58_RS02730	COG2814	Major facilitator Superfamily
LSO58_RS02735	COG0583	DNA-binding transcription factor activity
LSO58_RS02750	COG1295	ribonuclease BN
LSO58_RS02785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LSO58_RS02790	COG1702	phosphate starvation-inducible protein PhoH
LSO58_RS02795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LSO58_RS02800	COG0741	lytic transglycosylase activity
LSO58_RS02800	COG0739	heme binding
LSO58_RS02800	COG1196	nuclear chromosome segregation
LSO58_RS02810	COG0039	L-malate dehydrogenase activity
LSO58_RS02830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LSO58_RS02835	COG1183	phosphatidylcholine synthase activity
LSO58_RS02895	COG2969	positive regulation of protein catabolic process
LSO58_RS02900	COG0625	glutathione transferase activity
LSO58_RS02905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LSO58_RS02915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LSO58_RS02920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LSO58_RS02925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LSO58_RS02945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LSO58_RS02960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LSO58_RS02965	COG1408	metallophosphoesterase
LSO58_RS02970	COG0477	Major facilitator Superfamily
LSO58_RS02975	COG1272	protein, Hemolysin III
LSO58_RS02985	COG2153	protein acetylation
LSO58_RS02995	COG4667	esterase of the alpha-beta hydrolase superfamily
LSO58_RS03010	COG0183	Belongs to the thiolase family
LSO58_RS03025	COG2207	Transcriptional regulator
LSO58_RS03045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO58_RS03055	COG0442	prolyl-tRNA aminoacylation
LSO58_RS03090	COG0840	transmembrane signaling receptor activity
LSO58_RS03095	COG2198	Histidine kinase
LSO58_RS03095	COG0643	Histidine kinase
LSO58_RS03110	COG1690	Belongs to the RtcB family
LSO58_RS03115	COG0833	amino acid
LSO58_RS03120	COG2813	Specifically methylates the guanine in position
LSO58_RS03125	COG2233	PERMEase
LSO58_RS03130	COG1217	gtp-binding protein TYPA
LSO58_RS03145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LSO58_RS03150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LSO58_RS03155	COG2094	Belongs to the DNA glycosylase MPG family
LSO58_RS03160	COG4772	TonB-dependent receptor
LSO58_RS03165	COG1902	pentaerythritol trinitrate reductase activity
LSO58_RS03200	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LSO58_RS03255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LSO58_RS03260	COG0154	amidase activity
LSO58_RS03265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LSO58_RS03270	COG1077	Cell shape determining protein MreB Mrl
LSO58_RS03275	COG1792	Involved in formation and maintenance of cell shape
LSO58_RS03285	COG0424	maF-like protein
LSO58_RS03290	COG1530	ribonuclease E activity
LSO58_RS03300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LSO58_RS03310	COG0560	Phosphoserine phosphatase
LSO58_RS03325	COG2350	Protein conserved in bacteria
LSO58_RS03340	COG0583	DNA-binding transcription factor activity
LSO58_RS03345	COG0667	Aldo Keto reductase
LSO58_RS03350	COG3781	membrane
LSO58_RS03355	COG2003	Belongs to the UPF0758 family
LSO58_RS03360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LSO58_RS03365	COG3783	Cytochrome b(562)
LSO58_RS03375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LSO58_RS03385	COG1162	GTPase activity
LSO58_RS03390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LSO58_RS03400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LSO58_RS03400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LSO58_RS03410	COG1335	isochorismatase
LSO58_RS03415	COG0280	phosphate acetyltransferase
LSO58_RS03415	COG0857	belongs to the CobB CobQ family
LSO58_RS03420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LSO58_RS03425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LSO58_RS03430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSO58_RS03445	COG0793	Belongs to the peptidase S41A family
LSO58_RS03465	COG0105	UTP biosynthetic process
LSO58_RS03490	COG0124	histidyl-tRNA synthetase
LSO58_RS03525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LSO58_RS03535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LSO58_RS03550	COG2986	histidine ammonia-lyase
LSO58_RS03570	COG0644	oxidoreductase
LSO58_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS03595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LSO58_RS03625	COG1862	Preprotein translocase
LSO58_RS03635	COG1704	LemA family
LSO58_RS03645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LSO58_RS03750	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LSO58_RS03760	COG0732	type I restriction modification DNA specificity domain
LSO58_RS03775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LSO58_RS03805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LSO58_RS03820	COG0745	RESPONSE REGULATOR receiver
LSO58_RS03830	COG4774	siderophore transport
LSO58_RS03845	COG1230	cation diffusion facilitator family transporter
LSO58_RS03855	COG2814	Major facilitator Superfamily
LSO58_RS03865	COG0789	Transcriptional regulator
LSO58_RS03870	COG0697	spore germination
LSO58_RS03900	COG3706	GGDEF domain
LSO58_RS03905	COG2205	protein histidine kinase activity
LSO58_RS03910	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LSO58_RS03925	COG0726	polysaccharide deacetylase
LSO58_RS03930	COG0438	transferase activity, transferring glycosyl groups
LSO58_RS03940	COG0438	transferase activity, transferring glycosyl groups
LSO58_RS03955	COG1442	glycosyl transferase family 8
LSO58_RS03970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LSO58_RS04020	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS04025	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS04035	COG2205	protein histidine kinase activity
LSO58_RS04040	COG0745	RESPONSE REGULATOR receiver
LSO58_RS04045	COG2315	Protein conserved in bacteria
LSO58_RS04065	COG3956	TIGRFAM MazG family protein
LSO58_RS04070	COG1555	photosystem II stabilization
LSO58_RS04075	COG0617	tRNA 3'-terminal CCA addition
LSO58_RS04080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LSO58_RS04090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LSO58_RS04095	COG1660	Displays ATPase and GTPase activities
LSO58_RS04100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LSO58_RS04105	COG3028	Belongs to the UPF0307 family
LSO58_RS04110	COG0318	PFAM AMP-dependent synthetase and ligase
LSO58_RS04115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LSO58_RS04125	COG0625	glutathione transferase activity
LSO58_RS04130	COG1238	metal cluster binding
LSO58_RS04145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LSO58_RS04170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LSO58_RS04175	COG0072	phenylalanine-tRNA ligase activity
LSO58_RS04180	COG0776	regulation of translation
LSO58_RS04200	COG0248	Ppx GppA phosphatase
LSO58_RS04210	COG0037	tRNA processing
LSO58_RS04250	COG1846	Transcriptional regulator
LSO58_RS04255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LSO58_RS04315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LSO58_RS04320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LSO58_RS04330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LSO58_RS04390	COG1214	PFAM Peptidase M22, glycoprotease
LSO58_RS04395	COG1968	undecaprenyl-diphosphatase activity
LSO58_RS04400	COG0742	ribosomal rna small subunit methyltransferase
LSO58_RS04415	COG4269	membrane
LSO58_RS04430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LSO58_RS04440	COG2132	Multicopper oxidase
LSO58_RS04465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LSO58_RS04500	COG1074	ATP-dependent DNA helicase activity
LSO58_RS04505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LSO58_RS04520	COG0745	RESPONSE REGULATOR receiver
LSO58_RS04525	COG2205	protein histidine kinase activity
LSO58_RS04535	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO58_RS04540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO58_RS04545	COG0649	NAD binding
LSO58_RS04545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO58_RS04555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LSO58_RS04570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO58_RS04580	COG0713	ATP synthesis coupled electron transport
LSO58_RS04585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LSO58_RS04590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO58_RS04600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LSO58_RS04615	COG0583	DNA-binding transcription factor activity
LSO58_RS04635	COG0668	transmembrane transport
LSO58_RS04645	COG2081	HI0933 family
LSO58_RS04650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LSO58_RS04670	COG2226	methyltransferase
LSO58_RS04675	COG1280	lysine exporter protein (LysE YggA)
LSO58_RS04710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSO58_RS04715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSO58_RS04715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSO58_RS04725	COG0489	protein tyrosine kinase activity
LSO58_RS04730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LSO58_RS04745	COG0717	Belongs to the dCTP deaminase family
LSO58_RS04785	COG4372	Transposase
LSO58_RS04800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LSO58_RS04805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LSO58_RS04810	COG0628	permease
LSO58_RS04835	COG0583	DNA-binding transcription factor activity
LSO58_RS04840	COG0697	spore germination
LSO58_RS04845	COG1902	pentaerythritol trinitrate reductase activity
LSO58_RS04845	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSO58_RS04855	COG0582	viral genome integration into host DNA
LSO58_RS04965	COG2814	Major facilitator Superfamily
LSO58_RS04980	COG1230	cation diffusion facilitator family transporter
LSO58_RS04985	COG2059	Chromate
LSO58_RS05030	COG0601	transmembrane transport
LSO58_RS05035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSO58_RS05055	COG1132	(ABC) transporter
LSO58_RS05060	COG1132	(ABC) transporter
LSO58_RS05080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LSO58_RS05095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO58_RS05100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO58_RS05105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO58_RS05110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO58_RS05145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO58_RS05155	COG0583	DNA-binding transcription factor activity
LSO58_RS05165	COG0596	Alpha beta hydrolase
LSO58_RS05185	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LSO58_RS05190	COG2301	Belongs to the HpcH HpaI aldolase family
LSO58_RS05195	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS05200	COG0583	DNA-binding transcription factor activity
LSO58_RS05205	COG0477	Major facilitator Superfamily
LSO58_RS05220	COG0725	ABC transporter, periplasmic molybdate-binding protein
LSO58_RS05225	COG4149	molybdate abc transporter
LSO58_RS05230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LSO58_RS05235	COG0183	Belongs to the thiolase family
LSO58_RS05240	COG2031	fatty acid transporter
LSO58_RS05260	COG2610	gluconate transmembrane transporter activity
LSO58_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS05280	COG1595	DNA-templated transcription, initiation
LSO58_RS05290	COG1629	transport
LSO58_RS05305	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
LSO58_RS05320	COG1024	Enoyl-CoA hydratase
LSO58_RS05325	COG2814	Major facilitator Superfamily
LSO58_RS05335	COG1309	transcriptional regulator
LSO58_RS05350	COG2072	flavoprotein involved in K transport
LSO58_RS05355	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LSO58_RS05360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LSO58_RS05380	COG1113	amino acid transport
LSO58_RS05395	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LSO58_RS05405	COG2267	carboxylic ester hydrolase activity
LSO58_RS05410	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LSO58_RS05435	COG2217	Heavy metal translocating P-type atpase
LSO58_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS05485	COG3079	Belongs to the UPF0149 family
LSO58_RS05490	COG0006	proline dipeptidase activity
LSO58_RS05495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO58_RS05500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO58_RS05515	COG3107	peptidoglycan biosynthetic process
LSO58_RS05520	COG0792	nuclease activity
LSO58_RS05545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LSO58_RS05550	COG0741	lytic transglycosylase activity
LSO58_RS05550	COG0741	lytic transglycosylase activity
LSO58_RS05550	COG1388	LysM domain
LSO58_RS05550	COG1388	LysM domain
LSO58_RS05555	COG4166	transmembrane transport
LSO58_RS05560	COG4174	ABC transporter (Permease)
LSO58_RS05565	COG4239	(ABC) transporter, permease
LSO58_RS05570	COG4172	Belongs to the ABC transporter superfamily
LSO58_RS05590	COG2351	hydroxyisourate hydrolase activity
LSO58_RS05600	COG1187	pseudouridine synthase activity
LSO58_RS05610	COG1823	symporter activity
LSO58_RS05615	COG0384	phenazine biosynthesis protein PhzF
LSO58_RS05620	COG0038	chloride channel
LSO58_RS05625	COG0612	Peptidase, M16
LSO58_RS05680	COG1522	sequence-specific DNA binding
LSO58_RS05700	COG1802	Transcriptional regulator
LSO58_RS05735	COG0174	glutamine synthetase
LSO58_RS05750	COG0436	Aminotransferase
LSO58_RS05760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LSO58_RS05765	COG2199	diguanylate cyclase activity
LSO58_RS05775	COG0556	nucleotide-excision repair
LSO58_RS05780	COG3040	lipid binding
LSO58_RS05785	COG2962	Rard protein
LSO58_RS05810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LSO58_RS05825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSO58_RS05835	COG2070	2-Nitropropane dioxygenase
LSO58_RS05840	COG0531	amino acid
LSO58_RS05845	COG4303	Ethanolamine ammonia lyase large subunit
LSO58_RS05850	COG4302	ethanolamine ammonia-lyase activity
LSO58_RS05855	COG0632	four-way junction helicase activity
LSO58_RS05880	COG1764	response to oxidative stress
LSO58_RS05885	COG2985	domain, Protein
LSO58_RS05895	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS05915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LSO58_RS05925	COG2195	Cleaves the N-terminal amino acid of tripeptides
LSO58_RS05930	COG3022	response to hydroperoxide
LSO58_RS05975	COG1643	Atp-dependent helicase
LSO58_RS05985	COG0243	molybdopterin cofactor binding
LSO58_RS05990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LSO58_RS06000	COG0833	amino acid
LSO58_RS06010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LSO58_RS06015	COG0418	dihydroorotase activity
LSO58_RS06020	COG2203	Gaf domain
LSO58_RS06020	COG3706	GGDEF domain
LSO58_RS06020	COG4251	negative regulation of phosphorylation
LSO58_RS06020	COG5001	Diguanylate cyclase
LSO58_RS06040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LSO58_RS06060	COG0823	Involved in the tonB-independent uptake of proteins
LSO58_RS06080	COG0824	Thioesterase
LSO58_RS06085	COG2255	four-way junction helicase activity
LSO58_RS06100	COG4521	taurine ABC transporter
LSO58_RS06105	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LSO58_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO58_RS06115	COG2175	clavaminate synthase activity
LSO58_RS06120	COG4993	Dehydrogenase
LSO58_RS06140	COG2814	Major facilitator Superfamily
LSO58_RS06145	COG0583	DNA-binding transcription factor activity
LSO58_RS06150	COG4638	Rieske (2fe-2S)
LSO58_RS06155	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LSO58_RS06160	COG0543	2 iron, 2 sulfur cluster binding
LSO58_RS06160	COG0633	Ferredoxin
LSO58_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS06170	COG3135	benzoate transporter
LSO58_RS06175	COG3485	protocatechuate 3,4-dioxygenase
LSO58_RS06180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LSO58_RS06185	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LSO58_RS06190	COG0583	DNA-binding transcription factor activity
LSO58_RS06195	COG4948	Mandelate Racemase Muconate Lactonizing
LSO58_RS06200	COG4829	muconolactone delta-isomerase
LSO58_RS06220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSO58_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS06245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO58_RS06260	COG0543	2 iron, 2 sulfur cluster binding
LSO58_RS06260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSO58_RS06265	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LSO58_RS06270	COG4638	Rieske (2fe-2S)
LSO58_RS06275	COG3293	Transposase
LSO58_RS06295	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LSO58_RS06305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LSO58_RS06310	COG1137	ATPase activity
LSO58_RS06345	COG4122	O-methyltransferase activity
LSO58_RS06355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LSO58_RS06365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LSO58_RS06395	COG1595	DNA-templated transcription, initiation
LSO58_RS06430	COG3152	Membrane
LSO58_RS06445	COG4774	siderophore transport
LSO58_RS06470	COG0657	acetylesterase activity
LSO58_RS06580	COG4968	Prepilin-type N-terminal cleavage methylation domain
LSO58_RS06605	COG4969	Belongs to the N-Me-Phe pilin family
LSO58_RS06625	COG4372	Transposase
LSO58_RS06665	COG5002	protein histidine kinase activity
LSO58_RS06675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LSO58_RS07320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LSO58_RS07330	COG2175	clavaminate synthase activity
LSO58_RS07350	COG0024	Methionine aminopeptidase
LSO58_RS07355	COG0052	Belongs to the universal ribosomal protein uS2 family
LSO58_RS07360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LSO58_RS07395	COG2951	lytic endotransglycosylase activity
LSO58_RS07400	COG0772	Belongs to the SEDS family
LSO58_RS07410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LSO58_RS07410	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LSO58_RS07415	COG0842	Transport permease protein
LSO58_RS07420	COG1131	(ABC) transporter
LSO58_RS07460	COG0642	Histidine kinase
LSO58_RS07465	COG0745	RESPONSE REGULATOR receiver
LSO58_RS07470	COG2194	sulfuric ester hydrolase activity
LSO58_RS07485	COG0671	phosphoesterase, PA-phosphatase related
LSO58_RS07495	COG0589	response to stress
LSO58_RS07505	COG1686	Belongs to the peptidase S11 family
LSO58_RS07515	COG0352	thiamine-phosphate diphosphorylase activity
LSO58_RS07525	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LSO58_RS07530	COG0564	pseudouridine synthase activity
LSO58_RS07540	COG0783	Belongs to the Dps family
LSO58_RS07545	COG1309	transcriptional regulator
LSO58_RS07565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LSO58_RS07570	COG0076	glutamate decarboxylase activity
LSO58_RS07575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LSO58_RS07580	COG0573	inorganic phosphate transmembrane transporter activity
LSO58_RS07590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LSO58_RS07595	COG0616	signal peptide processing
LSO58_RS07610	COG2915	High frequency lysogenization protein hflD homolog
LSO58_RS07615	COG0482	sulfurtransferase activity
LSO58_RS07625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LSO58_RS07630	COG1686	Belongs to the peptidase S11 family
LSO58_RS07645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LSO58_RS07655	COG0583	DNA-binding transcription factor activity
LSO58_RS07660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LSO58_RS07665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LSO58_RS07685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LSO58_RS07690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LSO58_RS07695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LSO58_RS07710	COG4716	Myosin-crossreactive antigen
LSO58_RS07720	COG3706	GGDEF domain
LSO58_RS07730	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS07735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LSO58_RS07795	COG0513	Belongs to the DEAD box helicase family
LSO58_RS07805	COG0778	Nitroreductase
LSO58_RS07830	COG0167	dihydroorotate dehydrogenase activity
LSO58_RS07835	COG1286	toxin biosynthetic process
LSO58_RS07860	COG4783	chaperone-mediated protein folding
LSO58_RS07870	COG1610	YqeY-like protein
LSO58_RS07890	COG0537	adenosine 5'-monophosphoramidase activity
LSO58_RS07920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LSO58_RS07930	COG3100	YcgL domain-containing protein
LSO58_RS07940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LSO58_RS07955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LSO58_RS07960	COG0360	Binds together with S18 to 16S ribosomal RNA
LSO58_RS07970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LSO58_RS07975	COG1845	cytochrome c oxidase, subunit III
LSO58_RS07980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LSO58_RS07985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LSO58_RS08000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LSO58_RS08005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO58_RS08015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LSO58_RS08020	COG2890	protein-(glutamine-N5) methyltransferase activity
LSO58_RS08025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO58_RS08030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO58_RS08045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LSO58_RS08050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO58_RS08085	COG3042	response to heat
LSO58_RS08090	COG1968	undecaprenyl-diphosphatase activity
LSO58_RS08115	COG2207	Transcriptional regulator
LSO58_RS08120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO58_RS08130	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS08135	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS08160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LSO58_RS08170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LSO58_RS08175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LSO58_RS08185	COG2205	protein histidine kinase activity
LSO58_RS08190	COG0745	RESPONSE REGULATOR receiver
LSO58_RS08200	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LSO58_RS08210	COG0729	surface antigen
LSO58_RS08255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LSO58_RS08265	COG2204	response regulator
LSO58_RS08270	COG3852	Histidine kinase
LSO58_RS08280	COG0528	UMP kinase activity
LSO58_RS08285	COG0233	cytoplasmic translational termination
LSO58_RS08290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LSO58_RS08295	COG0575	Belongs to the CDS family
LSO58_RS08320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LSO58_RS08330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LSO58_RS08345	COG2137	regulation of response to DNA damage stimulus
LSO58_RS08355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LSO58_RS08360	COG1011	Hydrolase
LSO58_RS08365	COG1218	3'(2'),5'-bisphosphate nucleotidase
LSO58_RS08375	COG3594	Acyltransferase
LSO58_RS08380	COG0268	Binds directly to 16S ribosomal RNA
LSO58_RS08385	COG0702	epimerase
LSO58_RS08390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LSO58_RS08405	COG0069	glutamate synthase activity
LSO58_RS08410	COG2850	peptidyl-arginine hydroxylation
LSO58_RS08420	COG0424	maF-like protein
LSO58_RS08430	COG0126	phosphoglycerate kinase activity
LSO58_RS08440	COG0191	fructose-bisphosphate aldolase activity
LSO58_RS08445	COG0697	spore germination
LSO58_RS08480	COG3698	Phosphodiester glycosidase
LSO58_RS08490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LSO58_RS08495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LSO58_RS08500	COG0506	proline dehydrogenase activity
LSO58_RS08500	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LSO58_RS08500	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LSO58_RS08510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSO58_RS08515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LSO58_RS08520	COG0477	Major facilitator Superfamily
LSO58_RS08525	COG2267	carboxylic ester hydrolase activity
LSO58_RS08535	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSO58_RS08535	COG1902	pentaerythritol trinitrate reductase activity
LSO58_RS08555	COG0504	CTP synthase activity
LSO58_RS08565	COG0148	phosphopyruvate hydratase activity
LSO58_RS08575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LSO58_RS08580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO58_RS08590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO58_RS08590	COG1116	anion transmembrane transporter activity
LSO58_RS08595	COG0745	RESPONSE REGULATOR receiver
LSO58_RS08600	COG2223	nitrite transmembrane transporter activity
LSO58_RS08605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO58_RS08605	COG2146	nitrite reductase [NAD(P)H] activity
LSO58_RS08610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO58_RS08615	COG0243	molybdopterin cofactor binding
LSO58_RS08640	COG0315	cyclic pyranopterin monophosphate synthase activity
LSO58_RS08640	COG0521	Mo-molybdopterin cofactor biosynthetic process
LSO58_RS08645	COG0303	'Molybdopterin
LSO58_RS08650	COG0725	ABC transporter, periplasmic molybdate-binding protein
LSO58_RS08660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO58_RS08665	COG0697	spore germination
LSO58_RS08685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LSO58_RS08690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LSO58_RS08720	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS08760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LSO58_RS08770	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LSO58_RS08780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LSO58_RS08785	COG0509	glycine decarboxylation via glycine cleavage system
LSO58_RS08800	COG1132	(ABC) transporter
LSO58_RS08805	COG0668	transmembrane transport
LSO58_RS08810	COG3122	Protein conserved in bacteria
LSO58_RS08825	COG0640	Transcriptional regulator
LSO58_RS08870	COG1538	Outer membrane efflux protein
LSO58_RS08875	COG1595	DNA-templated transcription, initiation
LSO58_RS08890	COG1027	Aspartate ammonia-lyase
LSO58_RS08895	COG0583	DNA-binding transcription factor activity
LSO58_RS08900	COG1846	Transcriptional regulator
LSO58_RS08910	COG3676	manually curated
LSO58_RS08920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO58_RS08925	COG1414	Transcriptional regulator
LSO58_RS08930	COG4993	Dehydrogenase
LSO58_RS08935	COG3659	wide pore channel activity
LSO58_RS08940	COG3420	alginic acid biosynthetic process
LSO58_RS08945	COG0710	3-dehydroquinate dehydratase activity
LSO58_RS08950	COG3485	protocatechuate 3,4-dioxygenase
LSO58_RS08955	COG3485	protocatechuate 3,4-dioxygenase
LSO58_RS08960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LSO58_RS08965	COG2271	Major facilitator Superfamily
LSO58_RS08970	COG0596	Alpha beta hydrolase
LSO58_RS08975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LSO58_RS08980	COG0183	Belongs to the thiolase family
LSO58_RS08985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LSO58_RS08990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LSO58_RS08995	COG1414	Transcriptional regulator
LSO58_RS09005	COG0583	DNA-binding transcription factor activity
LSO58_RS09010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LSO58_RS09015	COG0235	Class ii aldolase
LSO58_RS09020	COG1024	Enoyl-CoA hydratase
LSO58_RS09025	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS09035	COG2814	Major facilitator Superfamily
LSO58_RS09045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LSO58_RS09055	COG2814	Major facilitator Superfamily
LSO58_RS09060	COG2814	Major facilitator Superfamily
LSO58_RS09065	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS09070	COG1024	Enoyl-CoA hydratase
LSO58_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS09080	COG1250	3-hydroxyacyl-CoA dehydrogenase
LSO58_RS09085	COG0183	Belongs to the thiolase family
LSO58_RS09100	COG2814	Major facilitator Superfamily
LSO58_RS09115	COG2814	Major facilitator Superfamily
LSO58_RS09120	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LSO58_RS09120	COG0644	oxidoreductase
LSO58_RS09170	COG0583	DNA-binding transcription factor activity
LSO58_RS09175	COG1380	Effector of murein hydrolase LrgA
LSO58_RS09180	COG1346	cytolysis
LSO58_RS09195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LSO58_RS09210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LSO58_RS09220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LSO58_RS09230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LSO58_RS09265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LSO58_RS09270	COG2814	Major facilitator Superfamily
LSO58_RS09275	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS09280	COG0583	DNA-binding transcription factor activity
LSO58_RS09290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LSO58_RS09295	COG0583	DNA-binding transcription factor activity
LSO58_RS09300	COG0024	Methionine aminopeptidase
LSO58_RS09360	COG2814	Major facilitator Superfamily
LSO58_RS09365	COG1082	Xylose isomerase domain protein TIM barrel
LSO58_RS09375	COG0667	Aldo Keto reductase
LSO58_RS09385	COG1053	succinate dehydrogenase
LSO58_RS09390	COG1053	succinate dehydrogenase
LSO58_RS09400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LSO58_RS09420	COG1309	transcriptional regulator
LSO58_RS09425	COG3659	wide pore channel activity
LSO58_RS09440	COG1053	succinate dehydrogenase
LSO58_RS09445	COG1414	Transcriptional regulator
LSO58_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS09460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LSO58_RS09490	COG0822	iron-sulfur transferase activity
LSO58_RS09495	COG0316	Belongs to the HesB IscA family
LSO58_RS09525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LSO58_RS09545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LSO58_RS09550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LSO58_RS09555	COG1454	alcohol dehydrogenase
LSO58_RS09560	COG0824	Thioesterase
LSO58_RS09585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSO58_RS09590	COG2030	dehydratase
LSO58_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS09625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LSO58_RS09635	COG3135	benzoate transporter
LSO58_RS09645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LSO58_RS09660	COG0589	response to stress
LSO58_RS09670	COG0308	aminopeptidase N
LSO58_RS09685	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LSO58_RS09690	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LSO58_RS09700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LSO58_RS09705	COG1454	alcohol dehydrogenase
LSO58_RS09725	COG0505	Belongs to the CarA family
LSO58_RS09735	COG2353	YceI-like domain
LSO58_RS09750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LSO58_RS09755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LSO58_RS09785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LSO58_RS09785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LSO58_RS09795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LSO58_RS09810	COG2193	ferroxidase activity
LSO58_RS09815	COG4774	siderophore transport
LSO58_RS09830	COG0217	transcriptional regulatory protein
LSO58_RS09845	COG1126	abc transporter atp-binding protein
LSO58_RS09850	COG0765	amino acid transport
LSO58_RS09855	COG0765	amino acid transport
LSO58_RS09880	COG0542	response to heat
LSO58_RS09885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LSO58_RS09895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LSO58_RS09910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LSO58_RS09915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LSO58_RS09920	COG0569	domain protein
LSO58_RS09925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LSO58_RS09940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LSO58_RS09950	COG1585	Membrane protein implicated in regulation of membrane protease activity
LSO58_RS09965	COG1294	oxidase, subunit
LSO58_RS09970	COG4890	Cyd operon protein YbgT
LSO58_RS09990	COG0552	protein localization to endoplasmic reticulum
LSO58_RS10025	COG0517	IMP dehydrogenase activity
LSO58_RS10025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LSO58_RS10035	COG0305	Participates in initiation and elongation during chromosome replication
LSO58_RS10040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LSO58_RS10055	COG1305	Transglutaminase-like
LSO58_RS10065	COG2308	Evidence 4 Homologs of previously reported genes of
LSO58_RS10075	COG0445	tRNA wobble uridine modification
LSO58_RS10100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LSO58_RS10105	COG0138	bifunctional purine biosynthesis protein purh
LSO58_RS10115	COG1464	Belongs to the NlpA lipoprotein family
LSO58_RS10120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LSO58_RS10125	COG2011	ABC-type metal ion transport system permease component
LSO58_RS10170	COG0515	serine threonine protein kinase
LSO58_RS10170	COG2815	serine threonine protein kinase
LSO58_RS10205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LSO58_RS10210	COG4773	Receptor
LSO58_RS10230	COG0730	response to heat
LSO58_RS10235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LSO58_RS10245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LSO58_RS10260	COG1253	flavin adenine dinucleotide binding
LSO58_RS10280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LSO58_RS10300	COG0284	orotidine-5'-phosphate decarboxylase activity
LSO58_RS10315	COG0776	regulation of translation
LSO58_RS10325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LSO58_RS10380	COG0084	hydrolase, TatD family'
LSO58_RS10400	COG1663	tetraacyldisaccharide 4'-kinase activity
LSO58_RS10405	COG1132	(ABC) transporter
LSO58_RS10415	COG0811	peptide transport
LSO58_RS10420	COG1475	DNA binding
LSO58_RS10425	COG1192	Involved in chromosome partitioning
LSO58_RS10430	COG0357	Ribosomal RNA small subunit methyltransferase G
LSO58_RS10435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LSO58_RS10445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LSO58_RS10450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LSO58_RS10455	COG1923	regulation of RNA biosynthetic process
LSO58_RS10460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LSO58_RS10465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LSO58_RS10470	COG0802	atpase or kinase
LSO58_RS10475	COG0564	pseudouridine synthase activity
LSO58_RS10505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LSO58_RS10515	COG2707	UPF0756 membrane protein
LSO58_RS10525	COG0583	DNA-binding transcription factor activity
LSO58_RS10535	COG2814	Major facilitator Superfamily
LSO58_RS10540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LSO58_RS10545	COG0471	metal ion transport
LSO58_RS10550	COG1012	belongs to the aldehyde dehydrogenase family
LSO58_RS10575	COG1464	Belongs to the NlpA lipoprotein family
LSO58_RS10580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LSO58_RS10585	COG2011	ABC-type metal ion transport system permease component
LSO58_RS10590	COG0012	GTP binding
LSO58_RS10595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LSO58_RS10615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LSO58_RS10620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LSO58_RS10645	COG0386	Belongs to the glutathione peroxidase family
LSO58_RS10650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LSO58_RS10655	COG0436	Aminotransferase
LSO58_RS10700	COG3706	GGDEF domain
LSO58_RS10725	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LSO58_RS10730	COG0596	Alpha beta hydrolase
LSO58_RS10740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO58_RS10750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO58_RS10760	COG0714	Associated with various cellular activities
LSO58_RS10765	COG2879	small protein
LSO58_RS10770	COG1966	Carbon starvation protein
LSO58_RS10775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LSO58_RS10780	COG1509	lysine 2,3-aminomutase activity
LSO58_RS10810	COG4625	pathogenesis
LSO58_RS10820	COG0602	queuosine metabolic process
LSO58_RS10825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LSO58_RS10835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LSO58_RS10840	COG2353	YceI-like domain
LSO58_RS10845	COG1056	cytidyltransferase-related domain
LSO58_RS10845	COG1051	belongs to the nudix hydrolase family
LSO58_RS10850	COG1024	Enoyl-CoA hydratase
LSO58_RS10860	COG3323	Protein of unknown function (DUF1653)
LSO58_RS10860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LSO58_RS10870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LSO58_RS10870	COG0047	phosphoribosylformylglycinamidine synthase activity
LSO58_RS10880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LSO58_RS10880	COG3008	intermembrane lipid transfer
LSO58_RS10885	COG2995	paraquat-inducible protein a
LSO58_RS10930	COG0540	Belongs to the ATCase OTCase family
LSO58_RS10935	COG0116	Belongs to the methyltransferase superfamily
LSO58_RS10935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LSO58_RS10960	COG1765	OsmC-like protein
LSO58_RS10970	COG0667	Aldo Keto reductase
LSO58_RS10985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LSO58_RS10990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LSO58_RS11005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LSO58_RS11020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LSO58_RS11035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LSO58_RS11040	COG2252	PERMEase
LSO58_RS11050	COG0659	secondary active sulfate transmembrane transporter activity
LSO58_RS11060	COG1301	dicarboxylic acid transport
LSO58_RS11065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LSO58_RS11070	COG3139	Protein of unknown function (DUF1315)
LSO58_RS11075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LSO58_RS11080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LSO58_RS11090	COG0494	nUDIX hydrolase
LSO58_RS11100	COG0642	Histidine kinase
LSO58_RS11110	COG3111	PFAM Bacterial OB fold (BOF) protein
LSO58_RS11115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LSO58_RS11120	COG3706	GGDEF domain
LSO58_RS11125	COG1720	tRNA m6t6A37 methyltransferase activity
LSO58_RS11135	COG1335	isochorismatase
LSO58_RS11140	COG3384	dioxygenase
LSO58_RS11145	COG0826	peptidase U32
LSO58_RS11150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LSO58_RS11175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LSO58_RS11180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LSO58_RS11200	COG1301	dicarboxylic acid transport
LSO58_RS11210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LSO58_RS11230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LSO58_RS11235	COG1381	Involved in DNA repair and RecF pathway recombination
LSO58_RS11245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LSO58_RS11250	COG0571	ribonuclease III activity
LSO58_RS11260	COG0681	Belongs to the peptidase S26 family
LSO58_RS11265	COG0481	GTPase activity
LSO58_RS11275	COG0174	glutamine synthetase
LSO58_RS11280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSO58_RS11290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LSO58_RS11295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LSO58_RS11300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LSO58_RS11305	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LSO58_RS11315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LSO58_RS11320	COG4208	sulfate ABC transporter
LSO58_RS11325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LSO58_RS11330	COG0583	DNA-binding transcription factor activity
LSO58_RS11335	COG0254	rRNA binding
LSO58_RS11350	COG1067	ATP-dependent peptidase activity
LSO58_RS11355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSO58_RS11360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LSO58_RS11365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LSO58_RS11370	COG0512	Glutamine amidotransferase of anthranilate synthase
LSO58_RS11375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LSO58_RS11380	COG0134	indole-3-glycerol-phosphate synthase activity
LSO58_RS11395	COG3608	succinylglutamate desuccinylase aspartoacylase
LSO58_RS11395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LSO58_RS11400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LSO58_RS11410	COG0302	gtp cyclohydrolase
LSO58_RS11415	COG0586	Pfam SNARE associated Golgi protein
LSO58_RS11425	COG3739	integral membrane protein
LSO58_RS11430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LSO58_RS11440	COG1741	Belongs to the pirin family
LSO58_RS11445	COG3421	Type III restriction
LSO58_RS11450	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LSO58_RS11475	COG0842	Transport permease protein
LSO58_RS11480	COG1131	(ABC) transporter
LSO58_RS11495	COG0583	DNA-binding transcription factor activity
LSO58_RS11505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LSO58_RS11510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LSO58_RS11520	COG0037	tRNA processing
LSO58_RS11525	COG0741	lytic transglycosylase activity
LSO58_RS11525	COG0739	heme binding
LSO58_RS11525	COG1196	nuclear chromosome segregation
LSO58_RS11530	COG0501	Belongs to the peptidase M48B family
LSO58_RS11540	COG2239	Acts as a magnesium transporter
LSO58_RS11545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO58_RS11570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LSO58_RS11575	COG2188	Transcriptional regulator
LSO58_RS11585	COG1045	serine acetyltransferase
LSO58_RS11590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LSO58_RS11595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LSO58_RS11600	COG0459	protein refolding
LSO58_RS11605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LSO58_RS11620	COG1597	lipid kinase activity
LSO58_RS11625	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LSO58_RS11650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LSO58_RS11670	COG1929	Belongs to the glycerate kinase type-1 family
LSO58_RS11690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LSO58_RS11695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LSO58_RS11700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LSO58_RS11720	COG0505	Belongs to the CarA family
LSO58_RS11740	COG0589	response to stress
LSO58_RS11750	COG0589	response to stress
LSO58_RS11760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LSO58_RS11770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LSO58_RS11775	COG4181	ATPase activity
LSO58_RS11785	COG0288	reversible hydration of carbon dioxide
LSO58_RS11800	COG4771	TonB-dependent receptor
LSO58_RS11805	COG4771	TonB-dependent receptor
LSO58_RS11825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LSO58_RS11845	COG0306	phosphate transporter
LSO58_RS11855	COG0653	protein targeting
LSO58_RS11860	COG2852	Protein conserved in bacteria
LSO58_RS11890	COG2223	nitrite transmembrane transporter activity
LSO58_RS11900	COG2066	Belongs to the glutaminase family
LSO58_RS11905	COG0242	peptide deformylase activity
LSO58_RS11910	COG0561	phosphatase activity
LSO58_RS11925	COG0400	carboxylic ester hydrolase activity
LSO58_RS11955	COG1215	transferase activity, transferring glycosyl groups
LSO58_RS11960	COG0726	polysaccharide deacetylase
LSO58_RS11960	COG1649	PFAM Uncharacterised BCR, COG1649
LSO58_RS11975	COG4681	YaeQ
LSO58_RS11985	COG0523	cobalamin synthesis protein
LSO58_RS12000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LSO58_RS12000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LSO58_RS12020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LSO58_RS12035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LSO58_RS12040	COG1773	rubredoxin
LSO58_RS12045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO58_RS12055	COG0583	DNA-binding transcription factor activity
LSO58_RS12085	COG1733	regulation of RNA biosynthetic process
LSO58_RS12095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LSO58_RS12100	COG1648	precorrin-2 dehydrogenase activity
LSO58_RS12100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LSO58_RS12105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LSO58_RS12115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LSO58_RS12125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LSO58_RS12130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LSO58_RS12145	COG0671	phosphoesterase, PA-phosphatase related
LSO58_RS12150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO58_RS12160	COG1538	Outer membrane efflux protein
LSO58_RS12165	COG0393	Putative heavy-metal-binding
LSO58_RS12170	COG0393	Putative heavy-metal-binding
LSO58_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS12185	COG0525	valine-tRNA ligase activity
LSO58_RS12200	COG0004	ammonium transporteR
LSO58_RS12215	COG0745	RESPONSE REGULATOR receiver
LSO58_RS12220	COG2814	Major facilitator Superfamily
LSO58_RS12230	COG1752	Esterase of the alpha-beta hydrolase superfamily
LSO58_RS12245	COG0142	geranyltranstransferase activity
LSO58_RS12255	COG2828	Protein conserved in bacteria
LSO58_RS12260	COG1113	amino acid transport
LSO58_RS12280	COG2333	competence protein COMEC
LSO58_RS12280	COG0658	competence protein
LSO58_RS12285	COG1136	(ABC) transporter
LSO58_RS12305	COG1671	Belongs to the UPF0178 family
LSO58_RS12315	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LSO58_RS12325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO58_RS12365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LSO58_RS12380	COG3384	dioxygenase
LSO58_RS12390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LSO58_RS12395	COG2878	Part of a membrane complex involved in electron transport
LSO58_RS12400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LSO58_RS12410	COG0563	adenylate kinase activity
LSO58_RS12425	COG0768	penicillin binding
LSO58_RS12430	COG0742	ribosomal rna small subunit methyltransferase
LSO58_RS12455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LSO58_RS12460	COG0830	nickel cation binding
LSO58_RS12465	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LSO58_RS12470	COG0804	urea catabolic process
LSO58_RS12475	COG0832	Belongs to the urease beta subunit family
LSO58_RS12480	COG0831	urea catabolic process
LSO58_RS12485	COG0829	nickel cation binding
LSO58_RS12500	COG3015	lipoprotein NlpE involved in copper resistance
LSO58_RS12520	COG1253	flavin adenine dinucleotide binding
LSO58_RS12530	COG1116	anion transmembrane transporter activity
LSO58_RS12550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSO58_RS12560	COG0864	Transcriptional regulator
LSO58_RS12570	COG0439	Biotin carboxylase
LSO58_RS12605	COG2851	Citrate transporter
LSO58_RS12615	COG0175	sulfate reduction
LSO58_RS12620	COG1492	cobalamin metabolic process
LSO58_RS12645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LSO58_RS12655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LSO58_RS12685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LSO58_RS12725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LSO58_RS12735	COG0193	aminoacyl-tRNA hydrolase activity
LSO58_RS12745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LSO58_RS12755	COG1054	Belongs to the UPF0176 family
LSO58_RS12770	COG0586	Pfam SNARE associated Golgi protein
LSO58_RS12775	COG0500	methyltransferase
LSO58_RS12800	COG0321	lipoyl(octanoyl) transferase activity
LSO58_RS12815	COG0531	amino acid
LSO58_RS12820	COG2321	neutral zinc metallopeptidase
LSO58_RS12825	COG2354	Protein conserved in bacteria
LSO58_RS12835	COG1585	Membrane protein implicated in regulation of membrane protease activity
LSO58_RS12840	COG2268	Band 7 protein
LSO58_RS12855	COG1215	transferase activity, transferring glycosyl groups
LSO58_RS12860	COG1649	PFAM Uncharacterised BCR, COG1649
LSO58_RS12860	COG0726	polysaccharide deacetylase
LSO58_RS12875	COG0045	succinate-CoA ligase (ADP-forming) activity
LSO58_RS12880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LSO58_RS12895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LSO58_RS12900	COG1053	succinate dehydrogenase
LSO58_RS12905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LSO58_RS12910	COG2009	succinate dehydrogenase
LSO58_RS12920	COG1607	acyl-coa hydrolase
LSO58_RS12930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LSO58_RS12935	COG1309	transcriptional regulator
LSO58_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
LSO58_RS12945	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LSO58_RS12970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSO58_RS12975	COG1120	ATPase activity
LSO58_RS12990	COG0028	Belongs to the TPP enzyme family
LSO58_RS12995	COG1012	belongs to the aldehyde dehydrogenase family
LSO58_RS13000	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LSO58_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS13020	COG2271	Major facilitator Superfamily
LSO58_RS13025	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSO58_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS13055	COG1414	Transcriptional regulator
LSO58_RS13080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSO58_RS13105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSO58_RS13115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LSO58_RS13125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LSO58_RS13135	COG0084	hydrolase, TatD family'
LSO58_RS13150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LSO58_RS13165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LSO58_RS13175	COG0028	Belongs to the TPP enzyme family
LSO58_RS13200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO58_RS13205	COG0577	efflux transmembrane transporter activity
LSO58_RS13205	COG1136	(ABC) transporter
LSO58_RS13220	COG2223	nitrite transmembrane transporter activity
LSO58_RS13250	COG0583	DNA-binding transcription factor activity
LSO58_RS13255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LSO58_RS13260	COG0436	Aminotransferase
LSO58_RS13265	COG1301	dicarboxylic acid transport
LSO58_RS13270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LSO58_RS13280	COG2223	nitrite transmembrane transporter activity
LSO58_RS13285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LSO58_RS13325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO58_RS13330	COG2814	Major facilitator Superfamily
LSO58_RS13335	COG1566	PFAM secretion protein HlyD family protein
LSO58_RS13340	COG2050	protein possibly involved in aromatic compounds catabolism
LSO58_RS13365	COG0420	3'-5' exonuclease activity
LSO58_RS13380	COG1011	Hydrolase
LSO58_RS13385	COG1968	undecaprenyl-diphosphatase activity
LSO58_RS13405	COG0735	belongs to the Fur family
LSO58_RS13410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LSO58_RS13415	COG2914	Belongs to the UPF0125 (RnfH) family
LSO58_RS13430	COG0121	glutamine amidotransferase
LSO58_RS13440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LSO58_RS13445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LSO58_RS13450	COG0756	dUTP diphosphatase activity
LSO58_RS13460	COG2885	chlorophyll binding
LSO58_RS13465	COG0204	Acyl-transferase
LSO58_RS13475	COG0850	regulation of cytokinetic process
LSO58_RS13480	COG2894	cell division
LSO58_RS13485	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LSO58_RS13495	COG1280	lysine exporter protein (LysE YggA)
LSO58_RS13505	COG1674	ftsk spoiiie
LSO58_RS13505	COG0531	amino acid
LSO58_RS13510	COG0492	ferredoxin-NADP+ reductase activity
LSO58_RS13515	COG0500	methyltransferase
LSO58_RS13520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LSO58_RS13525	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LSO58_RS13530	COG0456	acetyltransferase
LSO58_RS13540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LSO58_RS13545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LSO58_RS13570	COG1981	membrane
LSO58_RS13590	COG0352	thiamine-phosphate diphosphorylase activity
LSO58_RS13590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LSO58_RS13590	COG0351	phosphomethylpyrimidine kinase
LSO58_RS13595	COG1733	regulation of RNA biosynthetic process
LSO58_RS13605	COG1652	LysM domain
LSO58_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS13630	COG1399	metal-binding, possibly nucleic acid-binding protein
LSO58_RS13635	COG3101	peptidyl-lysine hydroxylation
LSO58_RS13640	COG0009	L-threonylcarbamoyladenylate synthase
LSO58_RS13650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LSO58_RS13655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LSO58_RS13675	COG4106	trans-aconitate 2-methyltransferase activity
LSO58_RS13685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LSO58_RS13685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LSO58_RS13700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LSO58_RS13715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LSO58_RS13725	COG1196	nuclear chromosome segregation
LSO58_RS13735	COG0730	response to heat
LSO58_RS13740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LSO58_RS13740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LSO58_RS13750	COG3545	Serine hydrolase
LSO58_RS13755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LSO58_RS13765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSO58_RS13780	COG3422	double-strand break repair
LSO58_RS13785	COG0494	nUDIX hydrolase
LSO58_RS13790	COG2824	Alkylphosphonate utilization operon protein PhnA
LSO58_RS13805	COG1752	Esterase of the alpha-beta hydrolase superfamily
LSO58_RS13810	COG1115	amino acid carrier protein
LSO58_RS13815	COG0786	glutamate:sodium symporter activity
LSO58_RS13830	COG2814	Major facilitator Superfamily
LSO58_RS13835	COG1289	transmembrane transporter activity
LSO58_RS13845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LSO58_RS13890	COG1376	ErfK ybiS ycfS ynhG family protein
LSO58_RS13895	COG2832	Protein of unknown function (DUF454)
LSO58_RS13905	COG5510	response to toxic substance
LSO58_RS13910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LSO58_RS13925	COG0183	Belongs to the thiolase family
LSO58_RS13955	COG1956	GAF domain-containing protein
LSO58_RS13960	COG1607	acyl-coa hydrolase
LSO58_RS14020	COG2199	diguanylate cyclase activity
LSO58_RS14025	COG2885	chlorophyll binding
LSO58_RS14050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LSO58_RS14055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LSO58_RS14065	COG0653	protein targeting
LSO58_RS14070	COG0450	alkyl hydroperoxide reductase
LSO58_RS14090	COG0285	dihydrofolate synthase activity
LSO58_RS14095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LSO58_RS14135	COG4206	TonB-dependent receptor
LSO58_RS14140	COG2096	Adenosyltransferase
LSO58_RS14160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LSO58_RS14180	COG5002	protein histidine kinase activity
LSO58_RS14180	COG0784	Response regulator, receiver
LSO58_RS14180	COG2205	protein histidine kinase activity
LSO58_RS14190	COG2084	Dehydrogenase
LSO58_RS14195	COG3622	Belongs to the hyi family
LSO58_RS14220	COG0740	serine-type endopeptidase activity
LSO58_RS14225	COG0544	peptidyl-prolyl cis-trans isomerase activity
LSO58_RS14230	COG4774	siderophore transport
LSO58_RS14235	COG3128	pkhd-type hydroxylase
LSO58_RS14240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LSO58_RS14245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSO58_RS14250	COG2813	Specifically methylates the guanine in position
LSO58_RS14250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSO58_RS14260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LSO58_RS14295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LSO58_RS14310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LSO58_RS14350	COG0788	formyltetrahydrofolate deformylase activity
LSO58_RS14355	COG1309	transcriptional regulator
LSO58_RS14375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LSO58_RS14375	COG4651	solute:proton antiporter activity
LSO58_RS14395	COG0210	DNA helicase
LSO58_RS14405	COG4251	negative regulation of phosphorylation
LSO58_RS14405	COG3706	GGDEF domain
LSO58_RS14405	COG2203	Gaf domain
LSO58_RS14405	COG5001	Diguanylate cyclase
LSO58_RS14435	COG2900	Belongs to the SlyX family
LSO58_RS14440	COG0488	(ABC) transporter
LSO58_RS14450	COG1560	Kdo2-lipid A biosynthetic process
LSO58_RS14455	COG0438	transferase activity, transferring glycosyl groups
LSO58_RS14460	COG1301	dicarboxylic acid transport
LSO58_RS14495	COG0101	tRNA pseudouridine synthase activity
LSO58_RS14500	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS14510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LSO58_RS14520	COG0473	3-isopropylmalate dehydrogenase activity
LSO58_RS14535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LSO58_RS14550	COG0583	DNA-binding transcription factor activity
LSO58_RS14565	COG0494	nUDIX hydrolase
LSO58_RS14575	COG1960	acyl-CoA dehydrogenase activity
LSO58_RS14585	COG0753	catalase activity
LSO58_RS14590	COG4993	Dehydrogenase
LSO58_RS14605	COG0583	DNA-binding transcription factor activity
LSO58_RS14620	COG0564	pseudouridine synthase activity
LSO58_RS14625	COG1530	ribonuclease E activity
LSO58_RS14630	COG0318	PFAM AMP-dependent synthetase and ligase
LSO58_RS14645	COG0450	alkyl hydroperoxide reductase
LSO58_RS14650	COG0583	DNA-binding transcription factor activity
LSO58_RS14655	COG4221	oxidoreductase activity
LSO58_RS14665	COG1595	DNA-templated transcription, initiation
LSO58_RS14675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LSO58_RS14685	COG0534	Mate efflux family protein
LSO58_RS14700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LSO58_RS14705	COG0254	rRNA binding
LSO58_RS14720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO58_RS14740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LSO58_RS14740	COG0493	'glutamate synthase
LSO58_RS14750	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LSO58_RS14760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSO58_RS14765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LSO58_RS14775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LSO58_RS14785	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LSO58_RS14785	COG0644	oxidoreductase
LSO58_RS14800	COG0425	Belongs to the sulfur carrier protein TusA family
LSO58_RS14805	COG4535	Mg2 and Co2 transporter CorC
LSO58_RS14810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LSO58_RS14815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSO58_RS14835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LSO58_RS14845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LSO58_RS14850	COG0484	heat shock protein binding
LSO58_RS14865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LSO58_RS14870	COG0598	Magnesium transport protein CorA
LSO58_RS14875	COG2841	Protein conserved in bacteria
LSO58_RS14880	COG1185	polyribonucleotide nucleotidyltransferase activity
LSO58_RS14885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LSO58_RS14890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSO58_RS14895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LSO58_RS14900	COG1074	ATP-dependent DNA helicase activity
LSO58_RS14905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LSO58_RS14930	COG2226	methyltransferase
LSO58_RS14940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LSO58_RS14965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LSO58_RS14965	COG2111	Na H antiporter
LSO58_RS14970	COG1006	Multisubunit Na H antiporter MnhC subunit
LSO58_RS14975	COG0651	ATP synthesis coupled electron transport
LSO58_RS14980	COG1863	multisubunit Na H antiporter MnhE subunit
LSO58_RS14985	COG2212	antiporter activity
LSO58_RS14990	COG1320	monovalent cation:proton antiporter activity
LSO58_RS15005	COG0195	Participates in both transcription termination and antitermination
LSO58_RS15010	COG0779	Required for maturation of 30S ribosomal subunits
LSO58_RS15035	COG0149	triose-phosphate isomerase activity
LSO58_RS15055	COG0237	dephospho-CoA kinase activity
LSO58_RS15065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LSO58_RS15070	COG3123	guanosine phosphorylase activity
LSO58_RS15075	COG0497	DNA recombination
LSO58_RS15080	COG1678	Uncharacterized ACR, COG1678
LSO58_RS15085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LSO58_RS15100	COG1289	transmembrane transporter activity
LSO58_RS15110	COG1132	(ABC) transporter
LSO58_RS15120	COG2169	Transcriptional regulator
LSO58_RS15120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LSO58_RS15125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LSO58_RS15150	COG1024	Enoyl-CoA hydratase
LSO58_RS15150	COG1250	3-hydroxyacyl-CoA dehydrogenase
LSO58_RS15175	COG3307	-O-antigen
LSO58_RS15185	COG3307	-O-antigen
LSO58_RS15190	COG4969	Belongs to the N-Me-Phe pilin family
LSO58_RS15200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LSO58_RS15205	COG1704	LemA family
LSO58_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS15225	COG0493	'glutamate synthase
LSO58_RS15230	COG0070	glutamate synthase
LSO58_RS15230	COG0069	glutamate synthase activity
LSO58_RS15230	COG0067	glutamate synthase
LSO58_RS15240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LSO58_RS15245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LSO58_RS15280	COG2226	methyltransferase
LSO58_RS15285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LSO58_RS15290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LSO58_RS15295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LSO58_RS15310	COG0275	rRNA processing
LSO58_RS15325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LSO58_RS15375	COG0488	(ABC) transporter
LSO58_RS15380	COG0028	Belongs to the TPP enzyme family
LSO58_RS15390	COG4221	oxidoreductase activity
LSO58_RS15420	COG0427	acetyl-CoA hydrolase
LSO58_RS15425	COG0456	acetyltransferase
LSO58_RS15455	COG0131	Imidazoleglycerol-phosphate dehydratase
LSO58_RS15460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LSO58_RS15470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LSO58_RS15490	COG1132	(ABC) transporter
LSO58_RS15495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO58_RS15500	COG0531	amino acid
LSO58_RS15520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LSO58_RS15560	COG3158	transport of potassium into the cell
LSO58_RS15570	COG0582	viral genome integration into host DNA
LSO58_RS15580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LSO58_RS15680	COG3177	Filamentation induced by cAMP protein fic
LSO58_RS15710	COG4372	Transposase
LSO58_RS15755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO58_RS15765	COG0179	Fumarylacetoacetate (FAA) hydrolase
LSO58_RS15780	COG2814	Major facilitator Superfamily
LSO58_RS15790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LSO58_RS15825	COG3706	GGDEF domain
LSO58_RS15845	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LSO58_RS15855	COG1335	isochorismatase
LSO58_RS15915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LSO58_RS15920	COG1113	amino acid transport
LSO58_RS15925	COG0251	oxidation-reduction process
LSO58_RS15935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO58_RS15945	COG1448	Aminotransferase
LSO58_RS15955	COG0277	FAD linked oxidase domain protein
LSO58_RS15960	COG1304	FMN binding
LSO58_RS15965	COG2186	Transcriptional regulator
LSO58_RS15970	COG1620	l-lactate permease
LSO58_RS15975	COG0583	DNA-binding transcription factor activity
LSO58_RS15980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LSO58_RS15995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LSO58_RS16010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LSO58_RS16015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LSO58_RS16020	COG1216	Glycosyl transferase, family 2
LSO58_RS16030	COG1216	Glycosyl transferase, family 2
LSO58_RS16040	COG1442	glycosyl transferase family 8
LSO58_RS16040	COG1216	Glycosyl transferase, family 2
LSO58_RS16050	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LSO58_RS16055	COG1596	polysaccharide export
LSO58_RS16085	COG3023	N-Acetylmuramoyl-L-alanine amidase
LSO58_RS16105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LSO58_RS16135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LSO58_RS16140	COG0546	phosphoglycolate phosphatase activity
LSO58_RS16145	COG1028	Short-chain dehydrogenase reductase Sdr
LSO58_RS16165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LSO58_RS16165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LSO58_RS16170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO58_RS16175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO58_RS16180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO58_RS16185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO58_RS16190	COG1116	anion transmembrane transporter activity
LSO58_RS16200	COG2233	PERMEase
LSO58_RS16205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO58_RS16210	COG0251	oxidation-reduction process
LSO58_RS16215	COG1335	isochorismatase
LSO58_RS16220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO58_RS16225	COG1309	transcriptional regulator
LSO58_RS16230	COG0596	Alpha beta hydrolase
LSO58_RS16245	COG0196	riboflavin kinase activity
LSO58_RS16250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LSO58_RS16255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LSO58_RS16260	COG1047	Peptidyl-prolyl cis-trans
LSO58_RS16305	COG2885	chlorophyll binding
LSO58_RS16305	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LSO58_RS16430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LSO58_RS16435	COG0657	acetylesterase activity
LSO58_RS16455	COG0583	DNA-binding transcription factor activity
LSO58_RS16460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LSO58_RS16465	COG0443	Heat shock 70 kDa protein
LSO58_RS16480	COG2951	lytic endotransglycosylase activity
LSO58_RS16485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LSO58_RS16500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LSO58_RS16525	COG0861	Integral membrane protein TerC family
LSO58_RS16535	COG0402	S-adenosylhomocysteine deaminase activity
LSO58_RS16550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LSO58_RS16560	COG0706	membrane insertase activity
LSO58_RS16565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LSO58_RS16570	COG0594	ribonuclease P activity
LSO58_RS16715	COG1475	DNA binding
LSO58_RS16720	COG1192	Involved in chromosome partitioning
LSO58_RS16970	COG1660	Displays ATPase and GTPase activities
LSO58_RS17060	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO58_RS17170	COG1538	Outer membrane efflux protein
LSO58_RS17175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO58_RS17185	COG0745	RESPONSE REGULATOR receiver
LSO58_RS17190	COG2205	protein histidine kinase activity
LSO58_RS17205	COG3173	Aminoglycoside phosphotransferase
LSO58_RS17210	COG0488	(ABC) transporter
LSO58_RS17305	COG0860	N-Acetylmuramoyl-L-alanine amidase
LSO58_RS17395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LSO58_RS17440	COG3421	Type III restriction
LSO58_RS17445	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LSO58_RS17455	COG1525	nuclease
LSO58_RS17505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LSO58_RS17660	COG2826	transposase and inactivated derivatives, IS30 family
LSO58_RS17845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LSO58_RS17850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LSO58_RS17880	COG2369	cell adhesion
LSO58_RS17885	COG0582	viral genome integration into host DNA
LSO58_RS17940	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO58_RS17965	COG2132	Multicopper oxidase
LSO58_RS17980	COG2205	protein histidine kinase activity
LSO58_RS17985	COG3174	membrane
LSO58_RS17990	COG2217	Heavy metal translocating P-type atpase
LSO58_RS18015	COG0431	NADPH-dependent FMN reductase
LSO58_RS18020	COG0798	PFAM Bile acid sodium symporter
LSO58_RS18030	COG0640	Transcriptional regulator
LSO58_RS18040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LSO58_RS18080	COG2233	PERMEase
LSO58_RS18100	COG0583	DNA-binding transcription factor activity
LSO58_RS18185	COG4372	Transposase
LSO58_RS18215	COG2072	flavoprotein involved in K transport
LSO58_RS18435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LSO58_RS18510	COG0739	heme binding
LSO58_RS18650	COG0501	Belongs to the peptidase M48B family
LSO58_RS18655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LSO58_RS18705	COG4974	Belongs to the 'phage' integrase family
LSO58_RS18735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LSO58_RS18795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LSO58_RS18815	COG2323	membrane
LSO58_RS18860	COG2223	nitrite transmembrane transporter activity
LSO58_RS18865	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LSO58_RS18870	COG1877	trehalose-phosphatase activity
LSO58_RS18885	COG1570	exodeoxyribonuclease VII activity
LSO58_RS18915	COG1309	transcriptional regulator
LSO58_RS18920	COG0604	alcohol dehydrogenase
LSO58_RS18950	COG4115	mRNA cleavage
LSO58_RS18990	COG2026	Addiction module toxin, RelE StbE family
LSO58_RS19005	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LSO58_RS19025	COG0582	viral genome integration into host DNA
LSO58_RS19040	COG2130	NADP-dependent
LSO58_RS19045	COG1309	transcriptional regulator
LSO58_RS19055	COG1902	pentaerythritol trinitrate reductase activity
LSO58_RS19065	COG1979	alcohol dehydrogenase
LSO58_RS19080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LSO58_RS19095	COG0604	alcohol dehydrogenase
LSO58_RS19095	COG3321	synthase
LSO58_RS19100	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LSO58_RS19105	COG0583	DNA-binding transcription factor activity
LSO58_RS19110	COG4221	oxidoreductase activity
LSO58_RS19150	COG3706	GGDEF domain
LSO58_RS19165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO58_RS19175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO58_RS19180	COG1113	amino acid transport
LSO58_RS19185	COG0697	spore germination
LSO58_RS19245	COG1475	DNA binding
LSO58_RS19250	COG1192	Involved in chromosome partitioning