locus-tag	class	description
N5980_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N5980_RS00010	COG0592	DNA-directed DNA polymerase activity
N5980_RS00020	COG0187	DNA topoisomerase II activity
N5980_RS00030	COG1063	alcohol dehydrogenase
N5980_RS00035	COG0488	(ABC) transporter
N5980_RS00090	COG0657	acetylesterase activity
N5980_RS00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N5980_RS00130	COG2814	Major facilitator Superfamily
N5980_RS00135	COG2814	Major facilitator Superfamily
N5980_RS00150	COG0693	protein deglycase activity
N5980_RS00160	COG1012	belongs to the aldehyde dehydrogenase family
N5980_RS00165	COG0733	neurotransmitter:sodium symporter activity
N5980_RS00175	COG0428	transporter
N5980_RS00190	COG0129	dihydroxy-acid dehydratase activity
N5980_RS00195	COG0129	dihydroxy-acid dehydratase activity
N5980_RS00220	COG2233	PERMEase
N5980_RS00235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5980_RS00275	COG0675	Transposase, IS605 OrfB family
N5980_RS00290	COG2814	Major facilitator Superfamily
N5980_RS00295	COG0656	L-ascorbic acid biosynthetic process
N5980_RS00300	COG0583	DNA-binding transcription factor activity
N5980_RS00305	COG1064	alcohol dehydrogenase
N5980_RS00310	COG2818	Glycosylase
N5980_RS00320	COG0739	heme binding
N5980_RS00325	COG1194	a g-specific adenine glycosylase
N5980_RS00370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N5980_RS00385	COG1091	dTDP-4-dehydrorhamnose reductase activity
N5980_RS00410	COG2030	dehydratase
N5980_RS00430	COG0438	transferase activity, transferring glycosyl groups
N5980_RS00435	COG0438	transferase activity, transferring glycosyl groups
N5980_RS00455	COG0438	transferase activity, transferring glycosyl groups
N5980_RS00460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N5980_RS00470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N5980_RS00480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N5980_RS00495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N5980_RS00550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N5980_RS00560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N5980_RS00565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N5980_RS00575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N5980_RS00600	COG4628	conserved protein (DUF2132)
N5980_RS00625	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS00650	COG0737	Belongs to the 5'-nucleotidase family
N5980_RS00690	COG3293	Transposase
N5980_RS00710	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N5980_RS00710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N5980_RS00715	COG1105	Belongs to the carbohydrate kinase PfkB family
N5980_RS00720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N5980_RS00720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N5980_RS00720	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N5980_RS00730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N5980_RS00735	COG3550	peptidyl-serine autophosphorylation
N5980_RS00805	COG0753	catalase activity
N5980_RS00820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5980_RS00885	COG1192	Involved in chromosome partitioning
N5980_RS00900	COG0586	Pfam SNARE associated Golgi protein
N5980_RS00905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N5980_RS00905	COG0519	Catalyzes the synthesis of GMP from XMP
N5980_RS00910	COG3706	GGDEF domain
N5980_RS00915	COG3706	GGDEF domain
N5980_RS00960	COG2175	clavaminate synthase activity
N5980_RS00975	COG0534	Mate efflux family protein
N5980_RS00980	COG0436	Aminotransferase
N5980_RS01000	COG2837	iron assimilation
N5980_RS01015	COG1683	Conserved Protein
N5980_RS01020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N5980_RS01025	COG1121	(ABC) transporter
N5980_RS01075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N5980_RS01090	COG1012	belongs to the aldehyde dehydrogenase family
N5980_RS01105	COG0386	Belongs to the glutathione peroxidase family
N5980_RS01110	COG0386	Belongs to the glutathione peroxidase family
N5980_RS01115	COG0697	spore germination
N5980_RS01125	COG0758	DNA mediated transformation
N5980_RS01175	COG2814	Major facilitator Superfamily
N5980_RS01195	COG0477	Major facilitator Superfamily
N5980_RS01200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N5980_RS01205	COG3757	hydrolase, family 25
N5980_RS01225	COG1253	flavin adenine dinucleotide binding
N5980_RS01235	COG2860	membrane
N5980_RS01240	COG0477	Major facilitator Superfamily
N5980_RS01250	COG0318	PFAM AMP-dependent synthetase and ligase
N5980_RS01265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N5980_RS01300	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS01325	COG4372	Transposase
N5980_RS01385	COG0347	Belongs to the P(II) protein family
N5980_RS01390	COG0004	ammonium transporteR
N5980_RS01400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5980_RS01400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5980_RS01415	COG0586	Pfam SNARE associated Golgi protein
N5980_RS01435	COG0795	lipopolysaccharide-transporting ATPase activity
N5980_RS01440	COG0795	lipopolysaccharide-transporting ATPase activity
N5980_RS01445	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N5980_RS01450	COG0793	Belongs to the peptidase S41A family
N5980_RS01450	COG3409	Peptidoglycan-binding domain 1 protein
N5980_RS01460	COG2205	protein histidine kinase activity
N5980_RS01465	COG2197	response regulator
N5980_RS01470	COG1686	Belongs to the peptidase S11 family
N5980_RS01480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N5980_RS01490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N5980_RS01495	COG4974	Belongs to the 'phage' integrase family
N5980_RS01520	COG0772	Belongs to the SEDS family
N5980_RS01530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5980_RS01535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N5980_RS01540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N5980_RS01545	COG0494	nUDIX hydrolase
N5980_RS01560	COG1538	Outer membrane efflux protein
N5980_RS01570	COG1132	(ABC) transporter
N5980_RS01580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N5980_RS01615	COG0497	DNA recombination
N5980_RS01620	COG3123	guanosine phosphorylase activity
N5980_RS01625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N5980_RS01635	COG0237	dephospho-CoA kinase activity
N5980_RS01655	COG0149	triose-phosphate isomerase activity
N5980_RS01690	COG0779	Required for maturation of 30S ribosomal subunits
N5980_RS01695	COG0195	Participates in both transcription termination and antitermination
N5980_RS01705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N5980_RS01710	COG1320	monovalent cation:proton antiporter activity
N5980_RS01715	COG2212	antiporter activity
N5980_RS01720	COG1863	multisubunit Na H antiporter MnhE subunit
N5980_RS01725	COG0651	ATP synthesis coupled electron transport
N5980_RS01730	COG1006	Multisubunit Na H antiporter MnhC subunit
N5980_RS01735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N5980_RS01735	COG2111	Na H antiporter
N5980_RS01750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N5980_RS01755	COG4221	oxidoreductase activity
N5980_RS01765	COG0488	(ABC) transporter
N5980_RS01775	COG3293	Transposase
N5980_RS01840	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N5980_RS01860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N5980_RS01865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N5980_RS01870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N5980_RS01875	COG2226	methyltransferase
N5980_RS01925	COG0067	glutamate synthase
N5980_RS01925	COG0069	glutamate synthase activity
N5980_RS01925	COG0070	glutamate synthase
N5980_RS01930	COG0493	'glutamate synthase
N5980_RS01935	COG1704	LemA family
N5980_RS01950	COG4969	Belongs to the N-Me-Phe pilin family
N5980_RS01965	COG3307	-O-antigen
N5980_RS01985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N5980_RS01990	COG1758	RNA polymerase activity
N5980_RS01995	COG0194	GDP metabolic process
N5980_RS02040	COG0228	four-way junction DNA binding
N5980_RS02045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N5980_RS02055	COG0335	large ribosomal subunit rRNA binding
N5980_RS02065	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N5980_RS02070	COG5380	lipid catabolic process
N5980_RS02075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N5980_RS02100	COG5006	permease, DMT superfamily
N5980_RS02105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N5980_RS02110	COG0277	FAD linked oxidase domain protein
N5980_RS02130	COG2814	Major facilitator Superfamily
N5980_RS02135	COG1289	transmembrane transporter activity
N5980_RS02145	COG0628	permease
N5980_RS02165	COG2226	methyltransferase
N5980_RS02180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N5980_RS02185	COG0254	rRNA binding
N5980_RS02190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N5980_RS02200	COG0534	Mate efflux family protein
N5980_RS02210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N5980_RS02220	COG1278	Cold shock
N5980_RS02225	COG1960	acyl-CoA dehydrogenase activity
N5980_RS02240	COG0408	coproporphyrinogen oxidase activity
N5980_RS02245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N5980_RS02255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N5980_RS02265	COG0513	Belongs to the DEAD box helicase family
N5980_RS02270	COG1127	ABC transporter
N5980_RS02275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N5980_RS02280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N5980_RS02285	COG2854	intermembrane phospholipid transfer
N5980_RS02295	COG0598	Magnesium transport protein CorA
N5980_RS02310	COG1040	competence protein
N5980_RS02315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N5980_RS02325	COG2937	Belongs to the GPAT DAPAT family
N5980_RS02330	COG1946	Acyl-CoA thioesterase
N5980_RS02335	COG1301	dicarboxylic acid transport
N5980_RS02355	COG1959	2 iron, 2 sulfur cluster binding
N5980_RS02370	COG0626	cystathionine gamma-synthase activity
N5980_RS02385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N5980_RS02390	COG0088	Forms part of the polypeptide exit tunnel
N5980_RS02405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N5980_RS02450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N5980_RS02455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N5980_RS02460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N5980_RS02470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N5980_RS02495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N5980_RS02505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N5980_RS02510	COG0202	RNA polymerase activity
N5980_RS02515	COG0203	ribosomal protein L17
N5980_RS02520	COG2072	flavoprotein involved in K transport
N5980_RS02525	COG1960	acyl-CoA dehydrogenase activity
N5980_RS02530	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N5980_RS02555	COG0697	spore germination
N5980_RS02565	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
N5980_RS02570	COG0339	signal peptide processing
N5980_RS02595	COG0557	exoribonuclease II activity
N5980_RS02635	COG0179	Fumarylacetoacetate (FAA) hydrolase
N5980_RS02645	COG1295	ribonuclease BN
N5980_RS02695	COG1702	phosphate starvation-inducible protein PhoH
N5980_RS02700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N5980_RS02705	COG0739	heme binding
N5980_RS02705	COG0741	lytic transglycosylase activity
N5980_RS02705	COG1196	nuclear chromosome segregation
N5980_RS02755	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N5980_RS02760	COG1183	phosphatidylcholine synthase activity
N5980_RS02820	COG1607	acyl-coa hydrolase
N5980_RS02850	COG2350	Protein conserved in bacteria
N5980_RS02865	COG3781	membrane
N5980_RS02870	COG2003	Belongs to the UPF0758 family
N5980_RS02875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N5980_RS02885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N5980_RS02945	COG1968	undecaprenyl-diphosphatase activity
N5980_RS02950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N5980_RS02955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N5980_RS02965	COG2205	protein histidine kinase activity
N5980_RS02970	COG0745	RESPONSE REGULATOR receiver
N5980_RS02985	COG0174	glutamine synthetase
N5980_RS03000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N5980_RS03010	COG0732	type I restriction modification DNA specificity domain
N5980_RS03025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N5980_RS03055	COG2814	Major facilitator Superfamily
N5980_RS03080	COG3622	Belongs to the hyi family
N5980_RS03085	COG2084	Dehydrogenase
N5980_RS03090	COG1024	Enoyl-CoA hydratase
N5980_RS03095	COG0784	Response regulator, receiver
N5980_RS03095	COG2205	protein histidine kinase activity
N5980_RS03095	COG5002	protein histidine kinase activity
N5980_RS03100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N5980_RS03115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N5980_RS03125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N5980_RS03135	COG1862	Preprotein translocase
N5980_RS03150	COG1704	LemA family
N5980_RS03160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N5980_RS03170	COG0318	PFAM AMP-dependent synthetase and ligase
N5980_RS03215	COG0625	glutathione transferase activity
N5980_RS03225	COG1238	metal cluster binding
N5980_RS03260	COG0072	phenylalanine-tRNA ligase activity
N5980_RS03285	COG0248	Ppx GppA phosphatase
N5980_RS03295	COG0037	tRNA processing
N5980_RS03335	COG1764	response to oxidative stress
N5980_RS03340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N5980_RS03415	COG2969	positive regulation of protein catabolic process
N5980_RS03420	COG0625	glutathione transferase activity
N5980_RS03425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N5980_RS03430	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N5980_RS03435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N5980_RS03440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N5980_RS03445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N5980_RS03475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N5980_RS03485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N5980_RS03490	COG1408	metallophosphoesterase
N5980_RS03500	COG0477	Major facilitator Superfamily
N5980_RS03505	COG1272	protein, Hemolysin III
N5980_RS03525	COG1024	Enoyl-CoA hydratase
N5980_RS03525	COG1250	3-hydroxyacyl-CoA dehydrogenase
N5980_RS03530	COG0183	Belongs to the thiolase family
N5980_RS03535	COG2207	Transcriptional regulator
N5980_RS03540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N5980_RS03545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5980_RS03560	COG0183	Belongs to the thiolase family
N5980_RS03580	COG0833	amino acid
N5980_RS03590	COG2233	PERMEase
N5980_RS03595	COG1217	gtp-binding protein TYPA
N5980_RS03620	COG1902	pentaerythritol trinitrate reductase activity
N5980_RS03635	COG0354	folic acid binding
N5980_RS03640	COG2132	Multicopper oxidase
N5980_RS03645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N5980_RS03655	COG4372	Transposase
N5980_RS03715	COG0564	pseudouridine synthase activity
N5980_RS03745	COG2824	Alkylphosphonate utilization operon protein PhnA
N5980_RS03770	COG0351	phosphomethylpyrimidine kinase
N5980_RS03770	COG0352	thiamine-phosphate diphosphorylase activity
N5980_RS03770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N5980_RS03805	COG3152	Membrane
N5980_RS03815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N5980_RS03830	COG0745	RESPONSE REGULATOR receiver
N5980_RS03835	COG2205	protein histidine kinase activity
N5980_RS03845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5980_RS03865	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N5980_RS03880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5980_RS03885	COG0839	Belongs to the complex I subunit 6 family
N5980_RS03890	COG0713	ATP synthesis coupled electron transport
N5980_RS03895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N5980_RS03900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5980_RS03925	COG1278	Cold shock
N5980_RS03930	COG0583	DNA-binding transcription factor activity
N5980_RS03950	COG0668	transmembrane transport
N5980_RS03965	COG2081	HI0933 family
N5980_RS03990	COG0004	ammonium transporteR
N5980_RS03995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5980_RS04005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5980_RS04005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5980_RS04015	COG0489	protein tyrosine kinase activity
N5980_RS04030	COG2358	TRAP transporter, solute receptor (TAXI family
N5980_RS04100	COG0840	transmembrane signaling receptor activity
N5980_RS04130	COG2832	Protein of unknown function (DUF454)
N5980_RS04190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N5980_RS04200	COG1289	transmembrane transporter activity
N5980_RS04205	COG2814	Major facilitator Superfamily
N5980_RS04215	COG0786	glutamate:sodium symporter activity
N5980_RS04220	COG1115	amino acid carrier protein
N5980_RS04225	COG2059	Chromate
N5980_RS04230	COG1752	Esterase of the alpha-beta hydrolase superfamily
N5980_RS04240	COG1607	acyl-coa hydrolase
N5980_RS04260	COG0625	glutathione transferase activity
N5980_RS04275	COG0523	cobalamin synthesis protein
N5980_RS04285	COG1285	pathogenesis
N5980_RS04295	COG2203	Gaf domain
N5980_RS04295	COG2199	diguanylate cyclase activity
N5980_RS04340	COG0393	Putative heavy-metal-binding
N5980_RS04345	COG0393	Putative heavy-metal-binding
N5980_RS04350	COG1538	Outer membrane efflux protein
N5980_RS04360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5980_RS04365	COG0671	phosphoesterase, PA-phosphatase related
N5980_RS04380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N5980_RS04390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N5980_RS04400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N5980_RS04405	COG1648	precorrin-2 dehydrogenase activity
N5980_RS04405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N5980_RS04410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N5980_RS04420	COG0531	amino acid
N5980_RS04435	COG0321	lipoyl(octanoyl) transferase activity
N5980_RS04445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N5980_RS04465	COG0586	Pfam SNARE associated Golgi protein
N5980_RS04490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N5980_RS04520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N5980_RS04550	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N5980_RS04560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N5980_RS04565	COG0358	DNA primase activity
N5980_RS04575	COG0564	pseudouridine synthase activity
N5980_RS04600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N5980_RS04620	COG0110	maltose O-acetyltransferase activity
N5980_RS04625	COG0251	oxidation-reduction process
N5980_RS04630	COG1309	transcriptional regulator
N5980_RS04640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N5980_RS04645	COG0505	Belongs to the CarA family
N5980_RS04670	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N5980_RS04675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N5980_RS04685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N5980_RS04720	COG1253	flavin adenine dinucleotide binding
N5980_RS04740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N5980_RS04750	COG2239	Acts as a magnesium transporter
N5980_RS04760	COG0501	Belongs to the peptidase M48B family
N5980_RS04765	COG0739	heme binding
N5980_RS04765	COG0741	lytic transglycosylase activity
N5980_RS04765	COG1196	nuclear chromosome segregation
N5980_RS04770	COG0037	tRNA processing
N5980_RS04785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N5980_RS04800	COG0583	DNA-binding transcription factor activity
N5980_RS04805	COG1960	acyl-CoA dehydrogenase activity
N5980_RS04810	COG2814	Major facilitator Superfamily
N5980_RS04825	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N5980_RS04850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N5980_RS04855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N5980_RS04860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N5980_RS04885	COG1115	amino acid carrier protein
N5980_RS04890	COG1113	amino acid transport
N5980_RS04915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N5980_RS04925	COG1522	sequence-specific DNA binding
N5980_RS04930	COG1280	lysine exporter protein (LysE YggA)
N5980_RS04970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5980_RS04995	COG1671	Belongs to the UPF0178 family
N5980_RS05015	COG1136	(ABC) transporter
N5980_RS05020	COG0658	competence protein
N5980_RS05020	COG2333	competence protein COMEC
N5980_RS05035	COG2267	carboxylic ester hydrolase activity
N5980_RS05040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N5980_RS05045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N5980_RS05050	COG0628	permease
N5980_RS05055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N5980_RS05085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N5980_RS05105	COG0823	Involved in the tonB-independent uptake of proteins
N5980_RS05125	COG0824	Thioesterase
N5980_RS05130	COG1473	amidohydrolase
N5980_RS05135	COG2255	four-way junction helicase activity
N5980_RS05160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N5980_RS05160	COG0047	phosphoribosylformylglycinamidine synthase activity
N5980_RS05175	COG0583	DNA-binding transcription factor activity
N5980_RS05195	COG1024	Enoyl-CoA hydratase
N5980_RS05200	COG1056	cytidyltransferase-related domain
N5980_RS05200	COG1051	belongs to the nudix hydrolase family
N5980_RS05205	COG2353	YceI-like domain
N5980_RS05210	COG0583	DNA-binding transcription factor activity
N5980_RS05215	COG1279	arginine transmembrane transporter activity
N5980_RS05220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N5980_RS05230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N5980_RS05235	COG0602	queuosine metabolic process
N5980_RS05255	COG0583	DNA-binding transcription factor activity
N5980_RS05260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N5980_RS05265	COG4208	sulfate ABC transporter
N5980_RS05270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N5980_RS05280	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N5980_RS05285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N5980_RS05295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N5980_RS05315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5980_RS05340	COG0571	ribonuclease III activity
N5980_RS05345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N5980_RS05355	COG1381	Involved in DNA repair and RecF pathway recombination
N5980_RS05360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N5980_RS05370	COG3293	Transposase
N5980_RS05400	COG0436	Aminotransferase
N5980_RS05410	COG0052	Belongs to the universal ribosomal protein uS2 family
N5980_RS05435	COG2951	lytic endotransglycosylase activity
N5980_RS05450	COG0842	Transport permease protein
N5980_RS05455	COG1131	(ABC) transporter
N5980_RS05510	COG2862	Uncharacterized protein family, UPF0114
N5980_RS05530	COG3634	alkyl hydroperoxide reductase activity
N5980_RS05535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N5980_RS05540	COG0826	peptidase U32
N5980_RS05565	COG4993	Dehydrogenase
N5980_RS05575	COG1720	tRNA m6t6A37 methyltransferase activity
N5980_RS05590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N5980_RS05605	COG0642	Histidine kinase
N5980_RS05615	COG0352	thiamine-phosphate diphosphorylase activity
N5980_RS05625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N5980_RS05630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N5980_RS05635	COG3139	Protein of unknown function (DUF1315)
N5980_RS05645	COG1301	dicarboxylic acid transport
N5980_RS05650	COG1960	acyl-CoA dehydrogenase activity
N5980_RS05655	COG0693	protein deglycase activity
N5980_RS05665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N5980_RS05670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N5980_RS05700	COG2252	PERMEase
N5980_RS05705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N5980_RS05720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N5980_RS05730	COG0527	aspartate kinase activity
N5980_RS05735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N5980_RS05740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N5980_RS05765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N5980_RS05770	COG0501	Belongs to the peptidase M48B family
N5980_RS05790	COG1252	NADH dehydrogenase
N5980_RS05795	COG1686	Belongs to the peptidase S11 family
N5980_RS05810	COG2351	hydroxyisourate hydrolase activity
N5980_RS05830	COG1187	pseudouridine synthase activity
N5980_RS05855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N5980_RS05855	COG2755	lipolytic protein G-D-S-L family
N5980_RS05865	COG0436	Aminotransferase
N5980_RS05870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N5980_RS05875	COG0386	Belongs to the glutathione peroxidase family
N5980_RS05885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N5980_RS05900	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N5980_RS05910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N5980_RS05915	COG0012	GTP binding
N5980_RS05920	COG2011	ABC-type metal ion transport system permease component
N5980_RS05925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N5980_RS05930	COG1464	Belongs to the NlpA lipoprotein family
N5980_RS06025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N5980_RS06025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N5980_RS06030	COG1254	Belongs to the acylphosphatase family
N5980_RS06065	COG3634	alkyl hydroperoxide reductase activity
N5980_RS06090	COG1643	Atp-dependent helicase
N5980_RS06110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N5980_RS06115	COG2707	UPF0756 membrane protein
N5980_RS06140	COG0802	atpase or kinase
N5980_RS06145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N5980_RS06155	COG1923	regulation of RNA biosynthetic process
N5980_RS06165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5980_RS06175	COG3178	'Phosphotransferase
N5980_RS06180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N5980_RS06190	COG1192	Involved in chromosome partitioning
N5980_RS06195	COG1475	DNA binding
N5980_RS06200	COG0811	peptide transport
N5980_RS06210	COG1132	(ABC) transporter
N5980_RS06215	COG1663	tetraacyldisaccharide 4'-kinase activity
N5980_RS06235	COG0084	hydrolase, TatD family'
N5980_RS06240	COG1309	transcriptional regulator
N5980_RS06270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N5980_RS06300	COG0776	regulation of translation
N5980_RS06320	COG2431	L-lysine efflux transmembrane transporter activity
N5980_RS06335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N5980_RS06340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N5980_RS06360	COG1253	flavin adenine dinucleotide binding
N5980_RS06365	COG3293	Transposase
N5980_RS06370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
N5980_RS06385	COG0308	aminopeptidase N
N5980_RS06395	COG0589	response to stress
N5980_RS06400	COG0589	response to stress
N5980_RS06410	COG3293	Transposase
N5980_RS06420	COG3135	benzoate transporter
N5980_RS06430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N5980_RS06445	COG0183	Belongs to the thiolase family
N5980_RS06475	COG0824	Thioesterase
N5980_RS06480	COG1454	alcohol dehydrogenase
N5980_RS06485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N5980_RS06505	COG0069	glutamate synthase activity
N5980_RS06515	COG2308	Evidence 4 Homologs of previously reported genes of
N5980_RS06525	COG1305	Transglutaminase-like
N5980_RS06540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N5980_RS06545	COG0305	Participates in initiation and elongation during chromosome replication
N5980_RS06560	COG0360	Binds together with S18 to 16S ribosomal RNA
N5980_RS06570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N5980_RS06575	COG1845	cytochrome c oxidase, subunit III
N5980_RS06580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N5980_RS06585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N5980_RS06610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5980_RS06625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N5980_RS06630	COG2890	protein-(glutamine-N5) methyltransferase activity
N5980_RS06635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5980_RS06640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5980_RS06665	COG1960	acyl-CoA dehydrogenase activity
N5980_RS06670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N5980_RS06685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N5980_RS06695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N5980_RS06715	COG0477	Major facilitator Superfamily
N5980_RS06720	COG0729	surface antigen
N5980_RS06735	COG1570	exodeoxyribonuclease VII activity
N5980_RS06775	COG4372	Transposase
N5980_RS06890	COG0305	Participates in initiation and elongation during chromosome replication
N5980_RS06910	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
N5980_RS06970	COG5410	chromosome segregation
N5980_RS07030	COG3561	AntA/AntB antirepressor
N5980_RS07160	COG0024	Methionine aminopeptidase
N5980_RS07165	COG0583	DNA-binding transcription factor activity
N5980_RS07170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N5980_RS07185	COG1902	pentaerythritol trinitrate reductase activity
N5980_RS07185	COG0446	pyridine nucleotide-disulphide oxidoreductase
N5980_RS07215	COG0148	phosphopyruvate hydratase activity
N5980_RS07230	COG0772	Belongs to the SEDS family
N5980_RS07245	COG4890	Cyd operon protein YbgT
N5980_RS07250	COG1294	oxidase, subunit
N5980_RS07300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N5980_RS07320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N5980_RS07330	COG0133	tryptophan synthase activity
N5980_RS07335	COG0516	GMP reductase activity
N5980_RS07335	COG0517	IMP dehydrogenase activity
N5980_RS07365	COG0612	Peptidase, M16
N5980_RS07370	COG0552	protein localization to endoplasmic reticulum
N5980_RS07430	COG1960	acyl-CoA dehydrogenase activity
N5980_RS07500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N5980_RS07505	COG0730	response to heat
N5980_RS07510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5980_RS07515	COG2207	Transcriptional regulator
N5980_RS07535	COG1960	acyl-CoA dehydrogenase activity
N5980_RS07560	COG1271	oxidase subunit
N5980_RS07565	COG1294	oxidase, subunit
N5980_RS07575	COG1525	nuclease
N5980_RS07630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N5980_RS07645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N5980_RS07665	COG0509	glycine decarboxylation via glycine cleavage system
N5980_RS07675	COG1132	(ABC) transporter
N5980_RS07680	COG0668	transmembrane transport
N5980_RS07690	COG3122	Protein conserved in bacteria
N5980_RS07715	COG0640	Transcriptional regulator
N5980_RS07720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N5980_RS07730	COG0789	Transcriptional regulator
N5980_RS07745	COG1960	acyl-CoA dehydrogenase activity
N5980_RS07750	COG0183	Belongs to the thiolase family
N5980_RS07770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5980_RS07775	COG0183	Belongs to the thiolase family
N5980_RS07780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N5980_RS07785	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N5980_RS07790	COG3135	benzoate transporter
N5980_RS07795	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS07800	COG0633	Ferredoxin
N5980_RS07800	COG0543	2 iron, 2 sulfur cluster binding
N5980_RS07805	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N5980_RS07810	COG4638	Rieske (2fe-2S)
N5980_RS07820	COG4829	muconolactone delta-isomerase
N5980_RS07825	COG4948	Mandelate Racemase Muconate Lactonizing
N5980_RS07830	COG0583	DNA-binding transcription factor activity
N5980_RS07835	COG2814	Major facilitator Superfamily
N5980_RS07845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N5980_RS07855	COG0318	PFAM AMP-dependent synthetase and ligase
N5980_RS07875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N5980_RS07880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N5980_RS07885	COG1116	anion transmembrane transporter activity
N5980_RS07885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5980_RS07910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N5980_RS07915	COG1309	transcriptional regulator
N5980_RS07935	COG1944	ATP diphosphatase activity
N5980_RS07945	COG1960	acyl-CoA dehydrogenase activity
N5980_RS07950	COG1960	acyl-CoA dehydrogenase activity
N5980_RS07955	COG2814	Major facilitator Superfamily
N5980_RS07965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N5980_RS07970	COG2814	Major facilitator Superfamily
N5980_RS07980	COG2814	Major facilitator Superfamily
N5980_RS07990	COG1250	3-hydroxyacyl-CoA dehydrogenase
N5980_RS07995	COG0183	Belongs to the thiolase family
N5980_RS08005	COG0235	Class ii aldolase
N5980_RS08010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N5980_RS08015	COG1024	Enoyl-CoA hydratase
N5980_RS08025	COG1960	acyl-CoA dehydrogenase activity
N5980_RS08030	COG2267	carboxylic ester hydrolase activity
N5980_RS08045	COG0318	PFAM AMP-dependent synthetase and ligase
N5980_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS08070	COG0640	Transcriptional regulator
N5980_RS08095	COG2132	Multicopper oxidase
N5980_RS08120	COG4773	Receptor
N5980_RS08130	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
N5980_RS08135	COG2116	formate transmembrane transporter activity
N5980_RS08140	COG0515	serine threonine protein kinase
N5980_RS08175	COG0583	DNA-binding transcription factor activity
N5980_RS08185	COG1289	transmembrane transporter activity
N5980_RS08215	COG2801	Transposase and inactivated derivatives
N5980_RS08220	COG4772	TonB-dependent receptor
N5980_RS08245	COG1079	Belongs to the binding-protein-dependent transport system permease family
N5980_RS08255	COG3845	ABC transporter
N5980_RS08275	COG0583	DNA-binding transcription factor activity
N5980_RS08285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5980_RS08290	COG4266	Belongs to the allantoicase family
N5980_RS08305	COG2233	PERMEase
N5980_RS08310	COG2351	hydroxyisourate hydrolase activity
N5980_RS08330	COG0804	urea catabolic process
N5980_RS08345	COG0829	nickel cation binding
N5980_RS08360	COG0830	nickel cation binding
N5980_RS08400	COG0596	Alpha beta hydrolase
N5980_RS08440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N5980_RS08475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N5980_RS08490	COG0439	Biotin carboxylase
N5980_RS08500	COG3706	GGDEF domain
N5980_RS08525	COG4372	Transposase
N5980_RS08565	COG5499	transcription regulator containing HTH domain
N5980_RS08570	COG4680	protein conserved in bacteria
N5980_RS08605	COG1058	Belongs to the CinA family
N5980_RS08605	COG1546	Belongs to the CinA family
N5980_RS08615	COG0372	Belongs to the citrate synthase family
N5980_RS08645	COG0542	response to heat
N5980_RS08650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N5980_RS08670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N5980_RS08675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N5980_RS08680	COG0569	domain protein
N5980_RS08685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N5980_RS08705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5980_RS08715	COG1585	Membrane protein implicated in regulation of membrane protease activity
N5980_RS08735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5980_RS08755	COG1959	2 iron, 2 sulfur cluster binding
N5980_RS08765	COG0822	iron-sulfur transferase activity
N5980_RS08770	COG0316	Belongs to the HesB IscA family
N5980_RS08800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N5980_RS08810	COG1027	Aspartate ammonia-lyase
N5980_RS08825	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N5980_RS08825	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N5980_RS08825	COG0506	proline dehydrogenase activity
N5980_RS08845	COG3781	membrane
N5980_RS08850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5980_RS08885	COG0697	spore germination
N5980_RS08910	COG0424	maF-like protein
N5980_RS08915	COG2850	peptidyl-arginine hydroxylation
N5980_RS08920	COG4585	Histidine kinase
N5980_RS08935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N5980_RS08940	COG0702	epimerase
N5980_RS08945	COG0268	Binds directly to 16S ribosomal RNA
N5980_RS08965	COG1011	Hydrolase
N5980_RS08970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N5980_RS08980	COG2137	regulation of response to DNA damage stimulus
N5980_RS08995	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5980_RS09000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N5980_RS09015	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5980_RS09030	COG0575	Belongs to the CDS family
N5980_RS09035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N5980_RS09055	COG3852	Histidine kinase
N5980_RS09070	COG0445	tRNA wobble uridine modification
N5980_RS09100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N5980_RS09105	COG0138	bifunctional purine biosynthesis protein purh
N5980_RS09120	COG1464	Belongs to the NlpA lipoprotein family
N5980_RS09125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N5980_RS09130	COG2011	ABC-type metal ion transport system permease component
N5980_RS09165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N5980_RS09175	COG4122	O-methyltransferase activity
N5980_RS09210	COG1137	ATPase activity
N5980_RS09215	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N5980_RS09225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N5980_RS09230	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N5980_RS09230	COG0517	IMP dehydrogenase activity
N5980_RS09280	COG0505	Belongs to the CarA family
N5980_RS09300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N5980_RS09320	COG2391	methyltransferase activity
N5980_RS09350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N5980_RS09380	COG2267	carboxylic ester hydrolase activity
N5980_RS09410	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS09425	COG0352	thiamine-phosphate diphosphorylase activity
N5980_RS09440	COG3025	triphosphatase activity
N5980_RS09460	COG0612	Peptidase, M16
N5980_RS09475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5980_RS09560	COG1610	YqeY-like protein
N5980_RS09575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5980_RS09625	COG0778	Nitroreductase
N5980_RS09635	COG0513	Belongs to the DEAD box helicase family
N5980_RS09655	COG2363	Small membrane protein
N5980_RS09680	COG2249	NAD(P)H dehydrogenase (quinone) activity
N5980_RS09690	COG0659	secondary active sulfate transmembrane transporter activity
N5980_RS09695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N5980_RS09715	COG0318	PFAM AMP-dependent synthetase and ligase
N5980_RS09720	COG1309	transcriptional regulator
N5980_RS09725	COG1960	acyl-CoA dehydrogenase activity
N5980_RS09730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N5980_RS09735	COG1024	Enoyl-CoA hydratase
N5980_RS09740	COG4770	biotin carboxylase activity
N5980_RS09755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N5980_RS09775	COG0540	Belongs to the ATCase OTCase family
N5980_RS09800	COG0667	Aldo Keto reductase
N5980_RS09810	COG1765	OsmC-like protein
N5980_RS09815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N5980_RS09825	COG3293	Transposase
N5980_RS09845	COG0714	Associated with various cellular activities
N5980_RS09850	COG2879	small protein
N5980_RS09855	COG1966	Carbon starvation protein
N5980_RS09860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N5980_RS09900	COG1067	ATP-dependent peptidase activity
N5980_RS09905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N5980_RS09910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N5980_RS09915	COG0583	DNA-binding transcription factor activity
N5980_RS09940	COG1686	Belongs to the peptidase S11 family
N5980_RS09945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N5980_RS09960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N5980_RS09960	COG2755	lipolytic protein G-D-S-L family
N5980_RS09970	COG0482	sulfurtransferase activity
N5980_RS10000	COG0616	signal peptide processing
N5980_RS10010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N5980_RS10020	COG0573	inorganic phosphate transmembrane transporter activity
N5980_RS10025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N5980_RS10030	COG1113	amino acid transport
N5980_RS10035	COG3961	Belongs to the TPP enzyme family
N5980_RS10040	COG1522	sequence-specific DNA binding
N5980_RS10045	COG1012	belongs to the aldehyde dehydrogenase family
N5980_RS10055	COG0076	glutamate decarboxylase activity
N5980_RS10060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N5980_RS10070	COG0671	phosphoesterase, PA-phosphatase related
N5980_RS10100	COG1733	regulation of RNA biosynthetic process
N5980_RS10115	COG3040	lipid binding
N5980_RS10120	COG0556	nucleotide-excision repair
N5980_RS10165	COG2721	sulfolactate sulfo-lyase activity
N5980_RS10185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N5980_RS10190	COG1960	acyl-CoA dehydrogenase activity
N5980_RS10200	COG2084	Dehydrogenase
N5980_RS10205	COG2233	PERMEase
N5980_RS10210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5980_RS10215	COG0251	oxidation-reduction process
N5980_RS10220	COG1335	isochorismatase
N5980_RS10225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5980_RS10230	COG0596	Alpha beta hydrolase
N5980_RS10240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5980_RS10245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N5980_RS10250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N5980_RS10290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N5980_RS10305	COG0174	glutamine synthetase
N5980_RS10310	COG3293	Transposase
N5980_RS10315	COG0512	Glutamine amidotransferase of anthranilate synthase
N5980_RS10320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N5980_RS10340	COG0302	gtp cyclohydrolase
N5980_RS10355	COG3706	GGDEF domain
N5980_RS10370	COG3739	integral membrane protein
N5980_RS10385	COG1741	Belongs to the pirin family
N5980_RS10405	COG1546	Belongs to the CinA family
N5980_RS10405	COG1058	Belongs to the CinA family
N5980_RS10425	COG0281	malic enzyme
N5980_RS10470	COG1785	Belongs to the alkaline phosphatase family
N5980_RS10475	COG1785	Belongs to the alkaline phosphatase family
N5980_RS10495	COG0446	pyridine nucleotide-disulphide oxidoreductase
N5980_RS10495	COG1902	pentaerythritol trinitrate reductase activity
N5980_RS10510	COG3706	GGDEF domain
N5980_RS10515	COG0418	dihydroorotase activity
N5980_RS10520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N5980_RS10535	COG0833	amino acid
N5980_RS10545	COG0833	amino acid
N5980_RS10585	COG4239	(ABC) transporter, permease
N5980_RS10590	COG4174	ABC transporter (Permease)
N5980_RS10595	COG4166	transmembrane transport
N5980_RS10600	COG0741	lytic transglycosylase activity
N5980_RS10600	COG1388	LysM domain
N5980_RS10615	COG2816	NAD+ diphosphatase activity
N5980_RS10620	COG0657	acetylesterase activity
N5980_RS10635	COG3107	peptidoglycan biosynthetic process
N5980_RS10650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5980_RS10655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5980_RS10665	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS10670	COG3293	Transposase
N5980_RS10675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N5980_RS10680	COG2155	Conserved Protein
N5980_RS10685	COG0006	proline dipeptidase activity
N5980_RS10710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N5980_RS10720	COG2234	aminopeptidase activity
N5980_RS10725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N5980_RS10730	COG3384	dioxygenase
N5980_RS10740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N5980_RS10745	COG2878	Part of a membrane complex involved in electron transport
N5980_RS10750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N5980_RS10775	COG0768	penicillin binding
N5980_RS10780	COG0742	ribosomal rna small subunit methyltransferase
N5980_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS10825	COG0459	protein refolding
N5980_RS10840	COG1597	lipid kinase activity
N5980_RS10850	COG0477	Major facilitator Superfamily
N5980_RS10865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N5980_RS10890	COG0604	alcohol dehydrogenase
N5980_RS10890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N5980_RS10890	COG3321	synthase
N5980_RS10890	COG4221	oxidoreductase activity
N5980_RS10900	COG3118	belongs to the thioredoxin family
N5980_RS10950	COG2268	Band 7 protein
N5980_RS10955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N5980_RS10965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N5980_RS10980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N5980_RS10985	COG1053	succinate dehydrogenase
N5980_RS10990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N5980_RS11010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N5980_RS11010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N5980_RS11025	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS11030	COG0589	response to stress
N5980_RS11050	COG2321	neutral zinc metallopeptidase
N5980_RS11055	COG2354	Protein conserved in bacteria
N5980_RS11085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N5980_RS11090	COG1773	rubredoxin
N5980_RS11095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5980_RS11105	COG0583	DNA-binding transcription factor activity
N5980_RS11120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N5980_RS11130	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N5980_RS11135	COG4181	ATPase activity
N5980_RS11160	COG4771	TonB-dependent receptor
N5980_RS11175	COG4607	ABC-type enterochelin transport system periplasmic component
N5980_RS11185	COG0306	phosphate transporter
N5980_RS11210	COG2376	Dihydroxyacetone kinase
N5980_RS11215	COG2066	Belongs to the glutaminase family
N5980_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS11230	COG0525	valine-tRNA ligase activity
N5980_RS11245	COG3293	Transposase
N5980_RS11265	COG2323	membrane
N5980_RS11270	COG0546	phosphoglycolate phosphatase activity
N5980_RS11290	COG1752	Esterase of the alpha-beta hydrolase superfamily
N5980_RS11305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N5980_RS11310	COG0142	geranyltranstransferase activity
N5980_RS11315	COG2828	Protein conserved in bacteria
N5980_RS11320	COG1113	amino acid transport
N5980_RS11340	COG0560	Phosphoserine phosphatase
N5980_RS11350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N5980_RS11365	COG0424	maF-like protein
N5980_RS11370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N5980_RS11375	COG1792	Involved in formation and maintenance of cell shape
N5980_RS11380	COG1077	Cell shape determining protein MreB Mrl
N5980_RS11385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N5980_RS11395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N5980_RS11430	COG0697	spore germination
N5980_RS11440	COG3590	peptidase
N5980_RS11445	COG3590	peptidase
N5980_RS11455	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
N5980_RS11470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N5980_RS11475	COG2223	nitrite transmembrane transporter activity
N5980_RS11485	COG0500	methyltransferase
N5980_RS11510	COG0783	Belongs to the Dps family
N5980_RS11530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N5980_RS11535	COG4149	molybdate abc transporter
N5980_RS11540	COG0725	ABC transporter, periplasmic molybdate-binding protein
N5980_RS11545	COG0303	'Molybdopterin
N5980_RS11550	COG0315	cyclic pyranopterin monophosphate synthase activity
N5980_RS11550	COG0521	Mo-molybdopterin cofactor biosynthetic process
N5980_RS11555	COG0314	molybdopterin synthase activity
N5980_RS11565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N5980_RS11575	COG0243	molybdopterin cofactor binding
N5980_RS11580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5980_RS11585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5980_RS11590	COG2223	nitrite transmembrane transporter activity
N5980_RS11605	COG0583	DNA-binding transcription factor activity
N5980_RS11620	COG0402	S-adenosylhomocysteine deaminase activity
N5980_RS11630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N5980_RS11665	COG4372	Transposase
N5980_RS11700	COG0582	viral genome integration into host DNA
N5980_RS11710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N5980_RS11715	COG2814	Major facilitator Superfamily
N5980_RS11720	COG1566	PFAM secretion protein HlyD family protein
N5980_RS11725	COG3293	Transposase
N5980_RS11730	COG2050	protein possibly involved in aromatic compounds catabolism
N5980_RS11740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5980_RS11745	COG1090	epimerase
N5980_RS11755	COG0420	3'-5' exonuclease activity
N5980_RS11785	COG0735	belongs to the Fur family
N5980_RS11790	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5980_RS11795	COG2914	Belongs to the UPF0125 (RnfH) family
N5980_RS11810	COG0121	glutamine amidotransferase
N5980_RS11825	COG0756	dUTP diphosphatase activity
N5980_RS11835	COG2885	chlorophyll binding
N5980_RS11840	COG0204	Acyl-transferase
N5980_RS11850	COG0850	regulation of cytokinetic process
N5980_RS11855	COG2894	cell division
N5980_RS11870	COG0531	amino acid
N5980_RS11870	COG1674	ftsk spoiiie
N5980_RS11875	COG0492	ferredoxin-NADP+ reductase activity
N5980_RS11880	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N5980_RS11890	COG0456	acetyltransferase
N5980_RS11915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N5980_RS11930	COG1981	membrane
N5980_RS11935	COG1113	amino acid transport
N5980_RS11940	COG0251	oxidation-reduction process
N5980_RS11960	COG1652	LysM domain
N5980_RS11965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N5980_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS11980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N5980_RS11985	COG1399	metal-binding, possibly nucleic acid-binding protein
N5980_RS11990	COG3101	peptidyl-lysine hydroxylation
N5980_RS11995	COG0009	L-threonylcarbamoyladenylate synthase
N5980_RS12010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N5980_RS12015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N5980_RS12040	COG0339	signal peptide processing
N5980_RS12050	COG4166	transmembrane transport
N5980_RS12060	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N5980_RS12080	COG2193	ferroxidase activity
N5980_RS12085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N5980_RS12090	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
N5980_RS12095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N5980_RS12105	COG1196	nuclear chromosome segregation
N5980_RS12115	COG0730	response to heat
N5980_RS12130	COG3545	Serine hydrolase
N5980_RS12140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N5980_RS12160	COG3327	negative regulation of DNA-templated transcription, initiation
N5980_RS12165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
N5980_RS12190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N5980_RS12200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N5980_RS12220	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N5980_RS12235	COG1968	undecaprenyl-diphosphatase activity
N5980_RS12240	COG1214	PFAM Peptidase M22, glycoprotease
N5980_RS12250	COG0494	nUDIX hydrolase
N5980_RS12305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N5980_RS12315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N5980_RS12400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N5980_RS12405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N5980_RS12445	COG0285	dihydrofolate synthase activity
N5980_RS12490	COG4206	TonB-dependent receptor
N5980_RS12495	COG2096	Adenosyltransferase
N5980_RS12510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N5980_RS12530	COG1113	amino acid transport
N5980_RS12540	COG0745	RESPONSE REGULATOR receiver
N5980_RS12545	COG2205	protein histidine kinase activity
N5980_RS12560	COG1960	acyl-CoA dehydrogenase activity
N5980_RS12565	COG1960	acyl-CoA dehydrogenase activity
N5980_RS12610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N5980_RS12670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N5980_RS12675	COG2205	protein histidine kinase activity
N5980_RS12690	COG1660	Displays ATPase and GTPase activities
N5980_RS12705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N5980_RS12710	COG0617	tRNA 3'-terminal CCA addition
N5980_RS12715	COG1596	polysaccharide export
N5980_RS12715	COG1555	photosystem II stabilization
N5980_RS12720	COG3956	TIGRFAM MazG family protein
N5980_RS12760	COG0124	histidyl-tRNA synthetase
N5980_RS12770	COG1426	Protein conserved in bacteria
N5980_RS12790	COG2975	iron-sulfur cluster assembly
N5980_RS12810	COG0028	Belongs to the TPP enzyme family
N5980_RS12840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5980_RS12845	COG0577	efflux transmembrane transporter activity
N5980_RS12845	COG1136	(ABC) transporter
N5980_RS12850	COG1538	Outer membrane efflux protein
N5980_RS12865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N5980_RS12875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N5980_RS12880	COG1162	GTPase activity
N5980_RS12910	COG0084	hydrolase, TatD family'
N5980_RS12925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N5980_RS12955	COG4251	negative regulation of phosphorylation
N5980_RS12955	COG3706	GGDEF domain
N5980_RS12955	COG5001	Diguanylate cyclase
N5980_RS12955	COG2203	Gaf domain
N5980_RS13000	COG0793	Belongs to the peptidase S41A family
N5980_RS13025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N5980_RS13030	COG0857	belongs to the CobB CobQ family
N5980_RS13030	COG0280	phosphate acetyltransferase
N5980_RS13040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N5980_RS13040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N5980_RS13055	COG0740	serine-type endopeptidase activity
N5980_RS13065	COG4774	siderophore transport
N5980_RS13075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N5980_RS13080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5980_RS13085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5980_RS13085	COG2813	Specifically methylates the guanine in position
N5980_RS13135	COG3040	lipid binding
N5980_RS13145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N5980_RS13165	COG4372	Transposase
N5980_RS13200	COG0210	DNA helicase
N5980_RS13240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N5980_RS13370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N5980_RS13405	COG0788	formyltetrahydrofolate deformylase activity
N5980_RS13430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N5980_RS13430	COG4651	solute:proton antiporter activity
N5980_RS13445	COG0724	RNA recognition motif
N5980_RS13450	COG0210	DNA helicase
N5980_RS13455	COG1929	Belongs to the glycerate kinase type-1 family
N5980_RS13495	COG2900	Belongs to the SlyX family
N5980_RS13500	COG0488	(ABC) transporter
N5980_RS13505	COG1560	Kdo2-lipid A biosynthetic process
N5980_RS13570	COG0473	3-isopropylmalate dehydrogenase activity
N5980_RS13585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N5980_RS13635	COG0753	catalase activity
N5980_RS13665	COG0519	Catalyzes the synthesis of GMP from XMP
N5980_RS13675	COG0446	pyridine nucleotide-disulphide oxidoreductase
N5980_RS13680	COG3384	dioxygenase
N5980_RS13685	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS13700	COG4638	Rieske (2fe-2S)
N5980_RS13705	COG0583	DNA-binding transcription factor activity
N5980_RS13725	COG4569	acetaldehyde dehydrogenase (acetylating) activity
N5980_RS13730	COG3971	2-oxopent-4-enoate hydratase activity
N5980_RS13735	COG0546	phosphoglycolate phosphatase activity
N5980_RS13750	COG1530	ribonuclease E activity
N5980_RS13755	COG0318	PFAM AMP-dependent synthetase and ligase
N5980_RS13780	COG1983	PspC domain protein
N5980_RS13790	COG0471	metal ion transport
N5980_RS13795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N5980_RS13795	COG0617	tRNA 3'-terminal CCA addition
N5980_RS13795	COG0517	IMP dehydrogenase activity
N5980_RS13805	COG0752	glycyl-tRNA synthetase alpha subunit
N5980_RS13810	COG0751	glycine-tRNA ligase activity
N5980_RS13845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5980_RS13875	COG0644	oxidoreductase
N5980_RS13885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N5980_RS13895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5980_RS13910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N5980_RS13920	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
N5980_RS13920	COG0644	oxidoreductase
N5980_RS13950	COG0425	Belongs to the sulfur carrier protein TusA family
N5980_RS13955	COG4535	Mg2 and Co2 transporter CorC
N5980_RS13980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N5980_RS13990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N5980_RS14015	COG0789	Transcriptional regulator
N5980_RS14020	COG2841	Protein conserved in bacteria
N5980_RS14030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N5980_RS14035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N5980_RS14040	COG1074	ATP-dependent DNA helicase activity
N5980_RS14045	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N5980_RS14065	COG2226	methyltransferase
N5980_RS14075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N5980_RS14105	COG0427	acetyl-CoA hydrolase
N5980_RS14110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N5980_RS14150	COG0326	Molecular chaperone. Has ATPase activity
N5980_RS14160	COG3047	cAMP biosynthetic process
N5980_RS14165	COG2056	Na+-H+ antiporter family
N5980_RS14185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N5980_RS14190	COG0085	RNA polymerase activity
N5980_RS14205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N5980_RS14265	COG0546	phosphoglycolate phosphatase activity
N5980_RS14295	COG0824	Thioesterase
N5980_RS14315	COG0181	hydroxymethylbilane synthase activity
N5980_RS14325	COG3275	phosphorelay sensor kinase activity
N5980_RS14340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N5980_RS14370	COG1024	Enoyl-CoA hydratase
N5980_RS14370	COG1250	3-hydroxyacyl-CoA dehydrogenase
N5980_RS14375	COG0183	Belongs to the thiolase family
N5980_RS14435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N5980_RS14465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N5980_RS14505	COG3158	transport of potassium into the cell
N5980_RS14560	COG0629	single-stranded DNA binding
N5980_RS14565	COG2814	Major facilitator Superfamily
N5980_RS14580	COG0351	phosphomethylpyrimidine kinase
N5980_RS14580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N5980_RS14580	COG0352	thiamine-phosphate diphosphorylase activity
N5980_RS14595	COG3706	GGDEF domain
N5980_RS14600	COG0675	Transposase, IS605 OrfB family
N5980_RS14615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N5980_RS14625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N5980_RS14630	COG3162	membrane
N5980_RS14635	COG2205	protein histidine kinase activity
N5980_RS14635	COG2198	Histidine kinase
N5980_RS14635	COG0784	Response regulator, receiver
N5980_RS14650	COG0431	NADPH-dependent FMN reductase
N5980_RS14660	COG0307	riboflavin synthase, alpha
N5980_RS14675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N5980_RS14685	COG0668	transmembrane transport
N5980_RS14690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N5980_RS14695	COG1519	Transferase
N5980_RS14700	COG1902	pentaerythritol trinitrate reductase activity
N5980_RS14725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N5980_RS14750	COG0426	domain, Protein
N5980_RS14750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5980_RS14755	COG2119	membrane
N5980_RS14785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N5980_RS14795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N5980_RS14805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N5980_RS14820	COG0189	ligase activity
N5980_RS14845	COG0708	Exodeoxyribonuclease III
N5980_RS14865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N5980_RS14875	COG3706	GGDEF domain
N5980_RS14925	COG3150	esterase
N5980_RS14935	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N5980_RS14940	COG2918	glutathione biosynthetic process
N5980_RS14955	COG2733	membrane
N5980_RS14995	COG0753	catalase activity
N5980_RS15015	COG3830	Belongs to the UPF0237 family
N5980_RS15015	COG0560	Phosphoserine phosphatase
N5980_RS15030	COG0385	Bile acid
N5980_RS15035	COG1335	isochorismatase
N5980_RS15045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N5980_RS15055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N5980_RS15060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N5980_RS15065	COG3300	MHYT domain
N5980_RS15065	COG5001	Diguanylate cyclase
N5980_RS15070	COG2983	Belongs to the UPF0260 family
N5980_RS15075	COG5487	UPF0391 membrane protein
N5980_RS15085	COG3023	N-Acetylmuramoyl-L-alanine amidase
N5980_RS15105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N5980_RS15115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N5980_RS15120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N5980_RS15125	COG0546	phosphoglycolate phosphatase activity
N5980_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS15160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N5980_RS15160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N5980_RS15165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5980_RS15170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5980_RS15175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5980_RS15180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5980_RS15185	COG1116	anion transmembrane transporter activity
N5980_RS15190	COG1309	transcriptional regulator
N5980_RS15200	COG0196	riboflavin kinase activity
N5980_RS15205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N5980_RS15215	COG1047	Peptidyl-prolyl cis-trans
N5980_RS15235	COG2133	pyrroloquinoline quinone binding
N5980_RS15275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N5980_RS15280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N5980_RS15285	COG2951	lytic endotransglycosylase activity
N5980_RS15290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N5980_RS15305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N5980_RS15330	COG2814	Major facilitator Superfamily
N5980_RS15335	COG0861	Integral membrane protein TerC family
N5980_RS15340	COG0402	S-adenosylhomocysteine deaminase activity
N5980_RS15355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N5980_RS15360	COG1230	cation diffusion facilitator family transporter
N5980_RS15385	COG0706	membrane insertase activity
N5980_RS15390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N5980_RS15395	COG0594	ribonuclease P activity
N5980_RS15410	COG0579	oxidoreductase
N5980_RS15435	COG2130	NADP-dependent
N5980_RS15440	COG1309	transcriptional regulator
N5980_RS15450	COG1902	pentaerythritol trinitrate reductase activity
N5980_RS15460	COG1979	alcohol dehydrogenase
N5980_RS15470	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N5980_RS15485	COG3321	synthase
N5980_RS15485	COG0604	alcohol dehydrogenase
N5980_RS15490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N5980_RS15495	COG0583	DNA-binding transcription factor activity
N5980_RS15500	COG4221	oxidoreductase activity
N5980_RS15550	COG4106	trans-aconitate 2-methyltransferase activity
N5980_RS15580	COG1215	transferase activity, transferring glycosyl groups
N5980_RS15595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N5980_RS15615	COG2267	carboxylic ester hydrolase activity
N5980_RS15615	COG2226	methyltransferase
N5980_RS15640	COG4774	siderophore transport
N5980_RS15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5980_RS15680	COG1454	alcohol dehydrogenase
N5980_RS15700	COG4774	siderophore transport
N5980_RS15705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N5980_RS15755	COG1192	Involved in chromosome partitioning
N5980_RS15790	COG1346	cytolysis
N5980_RS15795	COG1380	Effector of murein hydrolase LrgA
N5980_RS15800	COG0583	DNA-binding transcription factor activity
N5980_RS15805	COG1309	transcriptional regulator
N5980_RS15810	COG0604	alcohol dehydrogenase
N5980_RS15855	COG1280	lysine exporter protein (LysE YggA)
N5980_RS15860	COG3706	GGDEF domain
N5980_RS15900	COG0431	NADPH-dependent FMN reductase
N5980_RS15905	COG0798	PFAM Bile acid sodium symporter
N5980_RS15915	COG0640	Transcriptional regulator
N5980_RS15925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N5980_RS15930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N5980_RS15990	COG2217	Heavy metal translocating P-type atpase
N5980_RS16000	COG2205	protein histidine kinase activity
N5980_RS16015	COG2132	Multicopper oxidase
N5980_RS16120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N5980_RS16130	COG1846	Transcriptional regulator
N5980_RS16135	COG1764	response to oxidative stress
N5980_RS16200	COG1373	ATPase (AAA superfamily
N5980_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
N5980_RS16275	COG4372	Transposase
N5980_RS16300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N5980_RS16320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N5980_RS16325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5980_RS16330	COG0730	response to heat
N5980_RS16335	COG0583	DNA-binding transcription factor activity
N5980_RS16345	COG2194	sulfuric ester hydrolase activity
N5980_RS16350	COG0745	RESPONSE REGULATOR receiver
N5980_RS16355	COG0642	Histidine kinase
N5980_RS16450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N5980_RS16475	COG2369	cell adhesion
N5980_RS16480	COG0582	viral genome integration into host DNA
N5980_RS16485	COG0789	Transcriptional regulator
N5980_RS16495	COG1230	cation diffusion facilitator family transporter
N5980_RS16525	COG0789	Transcriptional regulator
N5980_RS16575	COG1309	transcriptional regulator
N5980_RS16600	COG0633	Ferredoxin
N5980_RS16605	COG2207	Transcriptional regulator
N5980_RS16710	COG3293	Transposase
N5980_RS16715	COG2076	Multidrug Resistance protein
N5980_RS16750	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS16780	COG1324	tolerance protein
N5980_RS16805	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS16815	COG2826	transposase and inactivated derivatives, IS30 family
N5980_RS16825	COG2801	Transposase and inactivated derivatives
N5980_RS16845	COG3657	addiction module killer protein
N5980_RS16850	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N5980_RS16855	COG3328	transposase activity
N5980_RS16860	COG2801	Transposase and inactivated derivatives
N5980_RS16880	COG0488	(ABC) transporter
N5980_RS16885	COG3173	Aminoglycoside phosphotransferase
N5980_RS16890	COG2801	Transposase and inactivated derivatives
N5980_RS16900	COG2801	Transposase and inactivated derivatives
N5980_RS16970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N5980_RS16985	COG0789	Transcriptional regulator