locus-tag	class	description
EGK58_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGK58_RS00010	COG0592	DNA-directed DNA polymerase activity
EGK58_RS00020	COG0187	DNA topoisomerase II activity
EGK58_RS00030	COG1063	alcohol dehydrogenase
EGK58_RS00035	COG0488	(ABC) transporter
EGK58_RS00090	COG0657	acetylesterase activity
EGK58_RS00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EGK58_RS00130	COG2814	Major facilitator Superfamily
EGK58_RS00135	COG2814	Major facilitator Superfamily
EGK58_RS00150	COG0693	protein deglycase activity
EGK58_RS00160	COG1012	belongs to the aldehyde dehydrogenase family
EGK58_RS00170	COG0733	neurotransmitter:sodium symporter activity
EGK58_RS00180	COG0428	transporter
EGK58_RS00195	COG0129	dihydroxy-acid dehydratase activity
EGK58_RS00205	COG0129	dihydroxy-acid dehydratase activity
EGK58_RS00230	COG2233	PERMEase
EGK58_RS00245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGK58_RS00295	COG0675	Transposase, IS605 OrfB family
EGK58_RS00305	COG1064	alcohol dehydrogenase
EGK58_RS00310	COG2818	Glycosylase
EGK58_RS00320	COG0739	heme binding
EGK58_RS00325	COG1194	a g-specific adenine glycosylase
EGK58_RS00360	COG1596	polysaccharide export
EGK58_RS00370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EGK58_RS00410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EGK58_RS00435	COG0438	transferase activity, transferring glycosyl groups
EGK58_RS00445	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EGK58_RS00450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EGK58_RS00465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGK58_RS00475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EGK58_RS00485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGK58_RS00500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGK58_RS00505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGK58_RS00560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EGK58_RS00570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGK58_RS00575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EGK58_RS00585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGK58_RS00605	COG4628	conserved protein (DUF2132)
EGK58_RS00625	COG3540	Alkaline phosphatase
EGK58_RS00640	COG3293	Transposase
EGK58_RS00645	COG0737	Belongs to the 5'-nucleotidase family
EGK58_RS00670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGK58_RS00670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGK58_RS00675	COG1105	Belongs to the carbohydrate kinase PfkB family
EGK58_RS00680	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EGK58_RS00680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGK58_RS00680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGK58_RS00685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGK58_RS00690	COG3550	peptidyl-serine autophosphorylation
EGK58_RS00745	COG1538	Outer membrane efflux protein
EGK58_RS00750	COG1132	(ABC) transporter
EGK58_RS00770	COG0753	catalase activity
EGK58_RS00795	COG3756	Protein conserved in bacteria
EGK58_RS00840	COG1192	Involved in chromosome partitioning
EGK58_RS00855	COG0586	Pfam SNARE associated Golgi protein
EGK58_RS00860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGK58_RS00860	COG0519	Catalyzes the synthesis of GMP from XMP
EGK58_RS00870	COG1715	Restriction endonuclease
EGK58_RS00880	COG3706	GGDEF domain
EGK58_RS00885	COG3706	GGDEF domain
EGK58_RS00925	COG2175	clavaminate synthase activity
EGK58_RS00940	COG0534	Mate efflux family protein
EGK58_RS00945	COG0436	Aminotransferase
EGK58_RS00980	COG2826	transposase and inactivated derivatives, IS30 family
EGK58_RS00995	COG2837	iron assimilation
EGK58_RS01000	COG1280	lysine exporter protein (LysE YggA)
EGK58_RS01005	COG1683	Conserved Protein
EGK58_RS01010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGK58_RS01015	COG1121	(ABC) transporter
EGK58_RS01065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGK58_RS01080	COG1012	belongs to the aldehyde dehydrogenase family
EGK58_RS01095	COG0386	Belongs to the glutathione peroxidase family
EGK58_RS01100	COG0386	Belongs to the glutathione peroxidase family
EGK58_RS01105	COG0697	spore germination
EGK58_RS01115	COG0758	DNA mediated transformation
EGK58_RS01180	COG2814	Major facilitator Superfamily
EGK58_RS01200	COG0477	Major facilitator Superfamily
EGK58_RS01205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGK58_RS01215	COG0477	Major facilitator Superfamily
EGK58_RS01230	COG1253	flavin adenine dinucleotide binding
EGK58_RS01240	COG2860	membrane
EGK58_RS01245	COG0477	Major facilitator Superfamily
EGK58_RS01255	COG0318	PFAM AMP-dependent synthetase and ligase
EGK58_RS01270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EGK58_RS01340	COG1324	tolerance protein
EGK58_RS01345	COG0673	inositol 2-dehydrogenase activity
EGK58_RS01365	COG2826	transposase and inactivated derivatives, IS30 family
EGK58_RS01395	COG2963	transposase activity
EGK58_RS01405	COG4372	Transposase
EGK58_RS01465	COG0347	Belongs to the P(II) protein family
EGK58_RS01470	COG0004	ammonium transporteR
EGK58_RS01480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGK58_RS01480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGK58_RS01495	COG0586	Pfam SNARE associated Golgi protein
EGK58_RS01515	COG0795	lipopolysaccharide-transporting ATPase activity
EGK58_RS01520	COG0795	lipopolysaccharide-transporting ATPase activity
EGK58_RS01525	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EGK58_RS01530	COG0793	Belongs to the peptidase S41A family
EGK58_RS01550	COG2205	protein histidine kinase activity
EGK58_RS01555	COG2197	response regulator
EGK58_RS01560	COG1686	Belongs to the peptidase S11 family
EGK58_RS01565	COG3385	transposase activity
EGK58_RS01570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EGK58_RS01580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGK58_RS01585	COG4974	Belongs to the 'phage' integrase family
EGK58_RS01610	COG0772	Belongs to the SEDS family
EGK58_RS01620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGK58_RS01625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EGK58_RS01630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EGK58_RS01635	COG0494	nUDIX hydrolase
EGK58_RS01650	COG1538	Outer membrane efflux protein
EGK58_RS01670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EGK58_RS01685	COG0497	DNA recombination
EGK58_RS01690	COG3123	guanosine phosphorylase activity
EGK58_RS01695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGK58_RS01705	COG0237	dephospho-CoA kinase activity
EGK58_RS01725	COG0149	triose-phosphate isomerase activity
EGK58_RS01760	COG0779	Required for maturation of 30S ribosomal subunits
EGK58_RS01765	COG0195	Participates in both transcription termination and antitermination
EGK58_RS01775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGK58_RS01780	COG1320	monovalent cation:proton antiporter activity
EGK58_RS01785	COG2212	antiporter activity
EGK58_RS01790	COG1863	multisubunit Na H antiporter MnhE subunit
EGK58_RS01795	COG0651	ATP synthesis coupled electron transport
EGK58_RS01800	COG1006	Multisubunit Na H antiporter MnhC subunit
EGK58_RS01805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGK58_RS01805	COG2111	Na H antiporter
EGK58_RS01820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGK58_RS01825	COG4221	oxidoreductase activity
EGK58_RS01830	COG2873	o-acetylhomoserine
EGK58_RS01835	COG0488	(ABC) transporter
EGK58_RS01870	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGK58_RS01875	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGK58_RS01895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGK58_RS01900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGK58_RS01905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGK58_RS01910	COG2226	methyltransferase
EGK58_RS01960	COG0067	glutamate synthase
EGK58_RS01960	COG0069	glutamate synthase activity
EGK58_RS01960	COG0070	glutamate synthase
EGK58_RS01965	COG0493	'glutamate synthase
EGK58_RS01970	COG1704	LemA family
EGK58_RS01995	COG3307	-O-antigen
EGK58_RS02015	COG0675	Transposase, IS605 OrfB family
EGK58_RS02020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGK58_RS02025	COG1758	RNA polymerase activity
EGK58_RS02030	COG0194	GDP metabolic process
EGK58_RS02055	COG0228	four-way junction DNA binding
EGK58_RS02060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EGK58_RS02070	COG0335	large ribosomal subunit rRNA binding
EGK58_RS02085	COG3293	Transposase
EGK58_RS02090	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EGK58_RS02095	COG5380	lipid catabolic process
EGK58_RS02100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGK58_RS02135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGK58_RS02140	COG0277	FAD linked oxidase domain protein
EGK58_RS02160	COG2814	Major facilitator Superfamily
EGK58_RS02165	COG1289	transmembrane transporter activity
EGK58_RS02180	COG0628	permease
EGK58_RS02210	COG2826	transposase and inactivated derivatives, IS30 family
EGK58_RS02220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGK58_RS02225	COG0254	rRNA binding
EGK58_RS02230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGK58_RS02240	COG0534	Mate efflux family protein
EGK58_RS02250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGK58_RS02260	COG1278	Cold shock
EGK58_RS02265	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS02280	COG0408	coproporphyrinogen oxidase activity
EGK58_RS02285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGK58_RS02300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EGK58_RS02310	COG0513	Belongs to the DEAD box helicase family
EGK58_RS02315	COG1127	ABC transporter
EGK58_RS02320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGK58_RS02325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGK58_RS02330	COG2854	intermembrane phospholipid transfer
EGK58_RS02340	COG0598	Magnesium transport protein CorA
EGK58_RS02355	COG1040	competence protein
EGK58_RS02360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EGK58_RS02370	COG2937	Belongs to the GPAT DAPAT family
EGK58_RS02375	COG1946	Acyl-CoA thioesterase
EGK58_RS02380	COG1301	dicarboxylic acid transport
EGK58_RS02400	COG1959	2 iron, 2 sulfur cluster binding
EGK58_RS02410	COG0433	COG0433 Predicted ATPase
EGK58_RS02415	COG0626	cystathionine gamma-synthase activity
EGK58_RS02430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGK58_RS02435	COG0088	Forms part of the polypeptide exit tunnel
EGK58_RS02450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGK58_RS02495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGK58_RS02500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EGK58_RS02505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGK58_RS02515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGK58_RS02540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGK58_RS02550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGK58_RS02555	COG0202	RNA polymerase activity
EGK58_RS02560	COG0203	ribosomal protein L17
EGK58_RS02565	COG2072	flavoprotein involved in K transport
EGK58_RS02570	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS02575	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EGK58_RS02600	COG0697	spore germination
EGK58_RS02610	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EGK58_RS02615	COG0339	signal peptide processing
EGK58_RS02625	COG0557	exoribonuclease II activity
EGK58_RS02665	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGK58_RS02675	COG1295	ribonuclease BN
EGK58_RS02730	COG1702	phosphate starvation-inducible protein PhoH
EGK58_RS02735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGK58_RS02740	COG0739	heme binding
EGK58_RS02740	COG1196	nuclear chromosome segregation
EGK58_RS02740	COG0741	lytic transglycosylase activity
EGK58_RS02780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EGK58_RS02785	COG1183	phosphatidylcholine synthase activity
EGK58_RS02845	COG1607	acyl-coa hydrolase
EGK58_RS02875	COG2350	Protein conserved in bacteria
EGK58_RS02890	COG3781	membrane
EGK58_RS02895	COG2003	Belongs to the UPF0758 family
EGK58_RS02900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EGK58_RS02910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGK58_RS02920	COG2814	Major facilitator Superfamily
EGK58_RS02945	COG3622	Belongs to the hyi family
EGK58_RS02950	COG2084	Dehydrogenase
EGK58_RS02955	COG1024	Enoyl-CoA hydratase
EGK58_RS02960	COG0784	Response regulator, receiver
EGK58_RS02960	COG2205	protein histidine kinase activity
EGK58_RS02960	COG5002	protein histidine kinase activity
EGK58_RS02980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGK58_RS02990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGK58_RS03000	COG1862	Preprotein translocase
EGK58_RS03015	COG1704	LemA family
EGK58_RS03025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EGK58_RS03035	COG0318	PFAM AMP-dependent synthetase and ligase
EGK58_RS03055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EGK58_RS03080	COG0625	glutathione transferase activity
EGK58_RS03090	COG1238	metal cluster binding
EGK58_RS03115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGK58_RS03120	COG0072	phenylalanine-tRNA ligase activity
EGK58_RS03145	COG0248	Ppx GppA phosphatase
EGK58_RS03155	COG0037	tRNA processing
EGK58_RS03195	COG1764	response to oxidative stress
EGK58_RS03200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGK58_RS03295	COG2969	positive regulation of protein catabolic process
EGK58_RS03300	COG0625	glutathione transferase activity
EGK58_RS03305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGK58_RS03310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGK58_RS03320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGK58_RS03325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGK58_RS03365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGK58_RS03380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGK58_RS03385	COG1408	metallophosphoesterase
EGK58_RS03395	COG0477	Major facilitator Superfamily
EGK58_RS03400	COG1272	protein, Hemolysin III
EGK58_RS03430	COG1024	Enoyl-CoA hydratase
EGK58_RS03430	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGK58_RS03435	COG0183	Belongs to the thiolase family
EGK58_RS03440	COG2207	Transcriptional regulator
EGK58_RS03445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGK58_RS03450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGK58_RS03470	COG0183	Belongs to the thiolase family
EGK58_RS03490	COG0833	amino acid
EGK58_RS03500	COG2233	PERMEase
EGK58_RS03505	COG1217	gtp-binding protein TYPA
EGK58_RS03530	COG1902	pentaerythritol trinitrate reductase activity
EGK58_RS03545	COG0354	folic acid binding
EGK58_RS03550	COG2132	Multicopper oxidase
EGK58_RS03555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EGK58_RS03605	COG0564	pseudouridine synthase activity
EGK58_RS03625	COG2824	Alkylphosphonate utilization operon protein PhnA
EGK58_RS03640	COG0351	phosphomethylpyrimidine kinase
EGK58_RS03640	COG0352	thiamine-phosphate diphosphorylase activity
EGK58_RS03640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EGK58_RS03670	COG3152	Membrane
EGK58_RS03680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGK58_RS03690	COG0745	RESPONSE REGULATOR receiver
EGK58_RS03695	COG2205	protein histidine kinase activity
EGK58_RS03710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGK58_RS03730	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EGK58_RS03745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGK58_RS03750	COG0839	Belongs to the complex I subunit 6 family
EGK58_RS03755	COG0713	ATP synthesis coupled electron transport
EGK58_RS03760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGK58_RS03765	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGK58_RS03795	COG0583	DNA-binding transcription factor activity
EGK58_RS03815	COG0668	transmembrane transport
EGK58_RS03830	COG2081	HI0933 family
EGK58_RS03855	COG0004	ammonium transporteR
EGK58_RS03870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGK58_RS03870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGK58_RS03880	COG0489	protein tyrosine kinase activity
EGK58_RS03895	COG2358	TRAP transporter, solute receptor (TAXI family
EGK58_RS03965	COG0840	transmembrane signaling receptor activity
EGK58_RS03995	COG2832	Protein of unknown function (DUF454)
EGK58_RS04055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGK58_RS04065	COG1289	transmembrane transporter activity
EGK58_RS04070	COG2814	Major facilitator Superfamily
EGK58_RS04080	COG0786	glutamate:sodium symporter activity
EGK58_RS04085	COG1115	amino acid carrier protein
EGK58_RS04090	COG2059	Chromate
EGK58_RS04095	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGK58_RS04105	COG1607	acyl-coa hydrolase
EGK58_RS04140	COG0523	cobalamin synthesis protein
EGK58_RS04150	COG1285	pathogenesis
EGK58_RS04160	COG2203	Gaf domain
EGK58_RS04160	COG2199	diguanylate cyclase activity
EGK58_RS04195	COG0242	peptide deformylase activity
EGK58_RS04200	COG0393	Putative heavy-metal-binding
EGK58_RS04205	COG0393	Putative heavy-metal-binding
EGK58_RS04210	COG1538	Outer membrane efflux protein
EGK58_RS04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGK58_RS04225	COG0671	phosphoesterase, PA-phosphatase related
EGK58_RS04240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGK58_RS04250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EGK58_RS04260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGK58_RS04265	COG1648	precorrin-2 dehydrogenase activity
EGK58_RS04265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGK58_RS04270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGK58_RS04280	COG0531	amino acid
EGK58_RS04295	COG0321	lipoyl(octanoyl) transferase activity
EGK58_RS04305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGK58_RS04325	COG0586	Pfam SNARE associated Golgi protein
EGK58_RS04350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGK58_RS04380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGK58_RS04410	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EGK58_RS04420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EGK58_RS04425	COG0358	DNA primase activity
EGK58_RS04435	COG0564	pseudouridine synthase activity
EGK58_RS04460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGK58_RS04480	COG0110	maltose O-acetyltransferase activity
EGK58_RS04485	COG0251	oxidation-reduction process
EGK58_RS04490	COG1309	transcriptional regulator
EGK58_RS04500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EGK58_RS04505	COG0505	Belongs to the CarA family
EGK58_RS04530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EGK58_RS04535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGK58_RS04545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGK58_RS04575	COG2851	Citrate transporter
EGK58_RS04580	COG1253	flavin adenine dinucleotide binding
EGK58_RS04600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGK58_RS04610	COG2239	Acts as a magnesium transporter
EGK58_RS04620	COG0501	Belongs to the peptidase M48B family
EGK58_RS04625	COG1196	nuclear chromosome segregation
EGK58_RS04625	COG0741	lytic transglycosylase activity
EGK58_RS04625	COG0739	heme binding
EGK58_RS04630	COG0037	tRNA processing
EGK58_RS04640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EGK58_RS04655	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EGK58_RS04670	COG2963	transposase activity
EGK58_RS04680	COG4372	Transposase
EGK58_RS04700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGK58_RS04735	COG0583	DNA-binding transcription factor activity
EGK58_RS04740	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS04750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EGK58_RS04775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGK58_RS04780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EGK58_RS04785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EGK58_RS04810	COG1115	amino acid carrier protein
EGK58_RS04815	COG1113	amino acid transport
EGK58_RS04840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EGK58_RS04850	COG1522	sequence-specific DNA binding
EGK58_RS04855	COG1280	lysine exporter protein (LysE YggA)
EGK58_RS04895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGK58_RS04915	COG1671	Belongs to the UPF0178 family
EGK58_RS04935	COG1136	(ABC) transporter
EGK58_RS04955	COG2267	carboxylic ester hydrolase activity
EGK58_RS04960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGK58_RS04965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGK58_RS04970	COG0628	permease
EGK58_RS04975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGK58_RS05005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGK58_RS05025	COG0823	Involved in the tonB-independent uptake of proteins
EGK58_RS05045	COG0824	Thioesterase
EGK58_RS05065	COG2255	four-way junction helicase activity
EGK58_RS05090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGK58_RS05090	COG0047	phosphoribosylformylglycinamidine synthase activity
EGK58_RS05100	COG0583	DNA-binding transcription factor activity
EGK58_RS05120	COG0778	Nitroreductase
EGK58_RS05125	COG1024	Enoyl-CoA hydratase
EGK58_RS05130	COG1051	belongs to the nudix hydrolase family
EGK58_RS05130	COG1056	cytidyltransferase-related domain
EGK58_RS05135	COG2353	YceI-like domain
EGK58_RS05140	COG0583	DNA-binding transcription factor activity
EGK58_RS05145	COG1279	arginine transmembrane transporter activity
EGK58_RS05150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGK58_RS05160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EGK58_RS05165	COG0602	queuosine metabolic process
EGK58_RS05185	COG0583	DNA-binding transcription factor activity
EGK58_RS05190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGK58_RS05195	COG4208	sulfate ABC transporter
EGK58_RS05200	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGK58_RS05210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGK58_RS05215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGK58_RS05225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EGK58_RS05245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGK58_RS05270	COG0571	ribonuclease III activity
EGK58_RS05275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGK58_RS05285	COG1381	Involved in DNA repair and RecF pathway recombination
EGK58_RS05290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EGK58_RS05320	COG0534	Mate efflux family protein
EGK58_RS05325	COG0436	Aminotransferase
EGK58_RS05335	COG0052	Belongs to the universal ribosomal protein uS2 family
EGK58_RS05360	COG2951	lytic endotransglycosylase activity
EGK58_RS05375	COG0842	Transport permease protein
EGK58_RS05380	COG1131	(ABC) transporter
EGK58_RS05410	COG4372	Transposase
EGK58_RS05420	COG2963	transposase activity
EGK58_RS05450	COG2862	Uncharacterized protein family, UPF0114
EGK58_RS05470	COG3634	alkyl hydroperoxide reductase activity
EGK58_RS05485	COG4993	Dehydrogenase
EGK58_RS05495	COG1720	tRNA m6t6A37 methyltransferase activity
EGK58_RS05525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGK58_RS05540	COG0642	Histidine kinase
EGK58_RS05550	COG0494	nUDIX hydrolase
EGK58_RS05560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGK58_RS05565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EGK58_RS05570	COG3139	Protein of unknown function (DUF1315)
EGK58_RS05580	COG1301	dicarboxylic acid transport
EGK58_RS05585	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS05590	COG0693	protein deglycase activity
EGK58_RS05600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGK58_RS05605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGK58_RS05635	COG2252	PERMEase
EGK58_RS05640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EGK58_RS05655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGK58_RS05665	COG0527	aspartate kinase activity
EGK58_RS05670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGK58_RS05675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGK58_RS05700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGK58_RS05705	COG0501	Belongs to the peptidase M48B family
EGK58_RS05725	COG1252	NADH dehydrogenase
EGK58_RS05730	COG1686	Belongs to the peptidase S11 family
EGK58_RS05745	COG2351	hydroxyisourate hydrolase activity
EGK58_RS05765	COG1187	pseudouridine synthase activity
EGK58_RS05810	COG0436	Aminotransferase
EGK58_RS05815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGK58_RS05820	COG0386	Belongs to the glutathione peroxidase family
EGK58_RS05830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EGK58_RS05845	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EGK58_RS05855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGK58_RS05860	COG0012	GTP binding
EGK58_RS05865	COG2011	ABC-type metal ion transport system permease component
EGK58_RS05870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGK58_RS05875	COG1464	Belongs to the NlpA lipoprotein family
EGK58_RS05965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGK58_RS05965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EGK58_RS06005	COG3634	alkyl hydroperoxide reductase activity
EGK58_RS06030	COG1643	Atp-dependent helicase
EGK58_RS06050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGK58_RS06055	COG2707	UPF0756 membrane protein
EGK58_RS06080	COG0802	atpase or kinase
EGK58_RS06085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGK58_RS06095	COG1923	regulation of RNA biosynthetic process
EGK58_RS06100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGK58_RS06110	COG3178	'Phosphotransferase
EGK58_RS06115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EGK58_RS06125	COG1192	Involved in chromosome partitioning
EGK58_RS06130	COG1475	DNA binding
EGK58_RS06135	COG0811	peptide transport
EGK58_RS06145	COG1132	(ABC) transporter
EGK58_RS06150	COG1663	tetraacyldisaccharide 4'-kinase activity
EGK58_RS06170	COG0084	hydrolase, TatD family'
EGK58_RS06175	COG1309	transcriptional regulator
EGK58_RS06205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EGK58_RS06235	COG0776	regulation of translation
EGK58_RS06255	COG2431	L-lysine efflux transmembrane transporter activity
EGK58_RS06270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EGK58_RS06315	COG1253	flavin adenine dinucleotide binding
EGK58_RS06340	COG0308	aminopeptidase N
EGK58_RS06350	COG0589	response to stress
EGK58_RS06355	COG0589	response to stress
EGK58_RS06370	COG3135	benzoate transporter
EGK58_RS06380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGK58_RS06395	COG0183	Belongs to the thiolase family
EGK58_RS06420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EGK58_RS06425	COG0824	Thioesterase
EGK58_RS06430	COG1454	alcohol dehydrogenase
EGK58_RS06435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGK58_RS06455	COG0069	glutamate synthase activity
EGK58_RS06465	COG2308	Evidence 4 Homologs of previously reported genes of
EGK58_RS06475	COG1305	Transglutaminase-like
EGK58_RS06490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGK58_RS06495	COG0305	Participates in initiation and elongation during chromosome replication
EGK58_RS06510	COG0360	Binds together with S18 to 16S ribosomal RNA
EGK58_RS06520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EGK58_RS06525	COG1845	cytochrome c oxidase, subunit III
EGK58_RS06530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EGK58_RS06535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EGK58_RS06560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGK58_RS06575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EGK58_RS06580	COG2890	protein-(glutamine-N5) methyltransferase activity
EGK58_RS06590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGK58_RS06595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGK58_RS06625	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS06630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGK58_RS06645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGK58_RS06655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EGK58_RS06670	COG0477	Major facilitator Superfamily
EGK58_RS06675	COG0729	surface antigen
EGK58_RS06690	COG1570	exodeoxyribonuclease VII activity
EGK58_RS06740	COG0786	glutamate:sodium symporter activity
EGK58_RS06765	COG0024	Methionine aminopeptidase
EGK58_RS06770	COG0583	DNA-binding transcription factor activity
EGK58_RS06775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGK58_RS06790	COG1902	pentaerythritol trinitrate reductase activity
EGK58_RS06790	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGK58_RS06820	COG0148	phosphopyruvate hydratase activity
EGK58_RS06835	COG0772	Belongs to the SEDS family
EGK58_RS06850	COG4890	Cyd operon protein YbgT
EGK58_RS06855	COG1294	oxidase, subunit
EGK58_RS06905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EGK58_RS06925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGK58_RS06935	COG0133	tryptophan synthase activity
EGK58_RS06940	COG0516	GMP reductase activity
EGK58_RS06940	COG0517	IMP dehydrogenase activity
EGK58_RS06970	COG0612	Peptidase, M16
EGK58_RS06975	COG0552	protein localization to endoplasmic reticulum
EGK58_RS07030	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS07100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGK58_RS07105	COG0730	response to heat
EGK58_RS07110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGK58_RS07115	COG2207	Transcriptional regulator
EGK58_RS07120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGK58_RS07125	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS07140	COG1476	TRANSCRIPTIONal
EGK58_RS07155	COG1271	oxidase subunit
EGK58_RS07160	COG1294	oxidase, subunit
EGK58_RS07170	COG1525	nuclease
EGK58_RS07225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGK58_RS07230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EGK58_RS07240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGK58_RS07255	COG2814	Major facilitator Superfamily
EGK58_RS07260	COG0509	glycine decarboxylation via glycine cleavage system
EGK58_RS07270	COG1132	(ABC) transporter
EGK58_RS07275	COG0668	transmembrane transport
EGK58_RS07285	COG3122	Protein conserved in bacteria
EGK58_RS07305	COG0640	Transcriptional regulator
EGK58_RS07310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGK58_RS07320	COG0789	Transcriptional regulator
EGK58_RS07335	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS07340	COG0183	Belongs to the thiolase family
EGK58_RS07370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGK58_RS07375	COG0183	Belongs to the thiolase family
EGK58_RS07380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EGK58_RS07385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EGK58_RS07390	COG3135	benzoate transporter
EGK58_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
EGK58_RS07400	COG0543	2 iron, 2 sulfur cluster binding
EGK58_RS07400	COG0633	Ferredoxin
EGK58_RS07405	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EGK58_RS07410	COG4638	Rieske (2fe-2S)
EGK58_RS07420	COG4829	muconolactone delta-isomerase
EGK58_RS07425	COG4948	Mandelate Racemase Muconate Lactonizing
EGK58_RS07430	COG0583	DNA-binding transcription factor activity
EGK58_RS07435	COG2814	Major facilitator Superfamily
EGK58_RS07445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGK58_RS07455	COG0318	PFAM AMP-dependent synthetase and ligase
EGK58_RS07475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGK58_RS07480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGK58_RS07485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGK58_RS07485	COG1116	anion transmembrane transporter activity
EGK58_RS07510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGK58_RS07515	COG1309	transcriptional regulator
EGK58_RS07535	COG1944	ATP diphosphatase activity
EGK58_RS07545	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS07550	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS07555	COG2814	Major facilitator Superfamily
EGK58_RS07560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EGK58_RS07565	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EGK58_RS07580	COG2814	Major facilitator Superfamily
EGK58_RS07590	COG2814	Major facilitator Superfamily
EGK58_RS07600	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGK58_RS07605	COG0183	Belongs to the thiolase family
EGK58_RS07615	COG0235	Class ii aldolase
EGK58_RS07620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGK58_RS07625	COG1024	Enoyl-CoA hydratase
EGK58_RS07635	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS07655	COG0318	PFAM AMP-dependent synthetase and ligase
EGK58_RS07660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGK58_RS07665	COG2814	Major facilitator Superfamily
EGK58_RS07675	COG1028	Short-chain dehydrogenase reductase Sdr
EGK58_RS07680	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EGK58_RS07690	COG0318	PFAM AMP-dependent synthetase and ligase
EGK58_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
EGK58_RS07730	COG1136	(ABC) transporter
EGK58_RS07740	COG0640	Transcriptional regulator
EGK58_RS07765	COG2132	Multicopper oxidase
EGK58_RS07790	COG4773	Receptor
EGK58_RS07795	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EGK58_RS07800	COG2116	formate transmembrane transporter activity
EGK58_RS07805	COG0515	serine threonine protein kinase
EGK58_RS07825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGK58_RS07830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGK58_RS07850	COG0583	DNA-binding transcription factor activity
EGK58_RS07860	COG1289	transmembrane transporter activity
EGK58_RS07890	COG4772	TonB-dependent receptor
EGK58_RS07915	COG0402	S-adenosylhomocysteine deaminase activity
EGK58_RS07920	COG1079	Belongs to the binding-protein-dependent transport system permease family
EGK58_RS07930	COG3845	ABC transporter
EGK58_RS07950	COG0583	DNA-binding transcription factor activity
EGK58_RS07960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGK58_RS07965	COG4266	Belongs to the allantoicase family
EGK58_RS07980	COG2233	PERMEase
EGK58_RS07985	COG2351	hydroxyisourate hydrolase activity
EGK58_RS08005	COG0804	urea catabolic process
EGK58_RS08020	COG0829	nickel cation binding
EGK58_RS08035	COG0830	nickel cation binding
EGK58_RS08075	COG0596	Alpha beta hydrolase
EGK58_RS08120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGK58_RS08155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGK58_RS08170	COG0439	Biotin carboxylase
EGK58_RS08185	COG3293	Transposase
EGK58_RS08190	COG3706	GGDEF domain
EGK58_RS08200	COG2814	Major facilitator Superfamily
EGK58_RS08240	COG5499	transcription regulator containing HTH domain
EGK58_RS08245	COG4680	protein conserved in bacteria
EGK58_RS08275	COG2826	transposase and inactivated derivatives, IS30 family
EGK58_RS08290	COG1546	Belongs to the CinA family
EGK58_RS08290	COG1058	Belongs to the CinA family
EGK58_RS08300	COG0372	Belongs to the citrate synthase family
EGK58_RS08340	COG0542	response to heat
EGK58_RS08345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EGK58_RS08365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EGK58_RS08370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGK58_RS08375	COG0569	domain protein
EGK58_RS08380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EGK58_RS08400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGK58_RS08410	COG1585	Membrane protein implicated in regulation of membrane protease activity
EGK58_RS08430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGK58_RS08450	COG1959	2 iron, 2 sulfur cluster binding
EGK58_RS08460	COG0822	iron-sulfur transferase activity
EGK58_RS08465	COG0316	Belongs to the HesB IscA family
EGK58_RS08495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGK58_RS08505	COG1027	Aspartate ammonia-lyase
EGK58_RS08520	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EGK58_RS08520	COG0506	proline dehydrogenase activity
EGK58_RS08520	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EGK58_RS08540	COG3781	membrane
EGK58_RS08580	COG0697	spore germination
EGK58_RS08605	COG0424	maF-like protein
EGK58_RS08610	COG2850	peptidyl-arginine hydroxylation
EGK58_RS08615	COG4585	Histidine kinase
EGK58_RS08620	COG2197	response regulator
EGK58_RS08630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EGK58_RS08635	COG0702	epimerase
EGK58_RS08640	COG0268	Binds directly to 16S ribosomal RNA
EGK58_RS08655	COG1011	Hydrolase
EGK58_RS08660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EGK58_RS08670	COG2137	regulation of response to DNA damage stimulus
EGK58_RS08685	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGK58_RS08690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGK58_RS08705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGK58_RS08720	COG0575	Belongs to the CDS family
EGK58_RS08725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EGK58_RS08745	COG3852	Histidine kinase
EGK58_RS08765	COG0445	tRNA wobble uridine modification
EGK58_RS08795	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EGK58_RS08800	COG0138	bifunctional purine biosynthesis protein purh
EGK58_RS08805	COG0151	Belongs to the GarS family
EGK58_RS08825	COG1464	Belongs to the NlpA lipoprotein family
EGK58_RS08830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGK58_RS08835	COG2011	ABC-type metal ion transport system permease component
EGK58_RS08870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EGK58_RS08880	COG4122	O-methyltransferase activity
EGK58_RS08915	COG1137	ATPase activity
EGK58_RS08920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EGK58_RS08930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EGK58_RS08935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EGK58_RS08935	COG0517	IMP dehydrogenase activity
EGK58_RS08970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGK58_RS08975	COG0183	Belongs to the thiolase family
EGK58_RS08980	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGK58_RS08985	COG1024	Enoyl-CoA hydratase
EGK58_RS08990	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS08995	COG2814	Major facilitator Superfamily
EGK58_RS09000	COG0644	oxidoreductase
EGK58_RS09000	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EGK58_RS09020	COG0625	glutathione transferase activity
EGK58_RS09025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGK58_RS09025	COG0519	Catalyzes the synthesis of GMP from XMP
EGK58_RS09030	COG2353	YceI-like domain
EGK58_RS09045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EGK58_RS09065	COG2391	methyltransferase activity
EGK58_RS09125	COG2267	carboxylic ester hydrolase activity
EGK58_RS09170	COG0352	thiamine-phosphate diphosphorylase activity
EGK58_RS09185	COG3025	triphosphatase activity
EGK58_RS09205	COG0612	Peptidase, M16
EGK58_RS09220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGK58_RS09270	COG2815	serine threonine protein kinase
EGK58_RS09270	COG0515	serine threonine protein kinase
EGK58_RS09295	COG2199	diguanylate cyclase activity
EGK58_RS09295	COG2203	Gaf domain
EGK58_RS09310	COG1610	YqeY-like protein
EGK58_RS09325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGK58_RS09375	COG0778	Nitroreductase
EGK58_RS09385	COG0513	Belongs to the DEAD box helicase family
EGK58_RS09405	COG2363	Small membrane protein
EGK58_RS09430	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGK58_RS09440	COG0659	secondary active sulfate transmembrane transporter activity
EGK58_RS09445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGK58_RS09465	COG0318	PFAM AMP-dependent synthetase and ligase
EGK58_RS09470	COG1309	transcriptional regulator
EGK58_RS09475	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS09480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGK58_RS09485	COG1024	Enoyl-CoA hydratase
EGK58_RS09490	COG4770	biotin carboxylase activity
EGK58_RS09505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EGK58_RS09510	COG2031	fatty acid transporter
EGK58_RS09530	COG0540	Belongs to the ATCase OTCase family
EGK58_RS09555	COG0667	Aldo Keto reductase
EGK58_RS09565	COG1765	OsmC-like protein
EGK58_RS09570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGK58_RS09600	COG0714	Associated with various cellular activities
EGK58_RS09605	COG2879	small protein
EGK58_RS09610	COG1966	Carbon starvation protein
EGK58_RS09615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGK58_RS09655	COG1067	ATP-dependent peptidase activity
EGK58_RS09660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EGK58_RS09665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EGK58_RS09670	COG0583	DNA-binding transcription factor activity
EGK58_RS09695	COG1686	Belongs to the peptidase S11 family
EGK58_RS09700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EGK58_RS09710	COG0488	(ABC) transporter
EGK58_RS09715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGK58_RS09715	COG2755	lipolytic protein G-D-S-L family
EGK58_RS09725	COG0482	sulfurtransferase activity
EGK58_RS09755	COG0616	signal peptide processing
EGK58_RS09765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGK58_RS09775	COG0573	inorganic phosphate transmembrane transporter activity
EGK58_RS09780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EGK58_RS09785	COG1113	amino acid transport
EGK58_RS09790	COG3961	Belongs to the TPP enzyme family
EGK58_RS09795	COG1522	sequence-specific DNA binding
EGK58_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
EGK58_RS09810	COG0076	glutamate decarboxylase activity
EGK58_RS09815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EGK58_RS09825	COG0671	phosphoesterase, PA-phosphatase related
EGK58_RS09850	COG1733	regulation of RNA biosynthetic process
EGK58_RS09865	COG3040	lipid binding
EGK58_RS09870	COG0556	nucleotide-excision repair
EGK58_RS09895	COG2175	clavaminate synthase activity
EGK58_RS09905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGK58_RS09910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGK58_RS09915	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS09925	COG2084	Dehydrogenase
EGK58_RS09930	COG2233	PERMEase
EGK58_RS09935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGK58_RS09940	COG0251	oxidation-reduction process
EGK58_RS09945	COG1335	isochorismatase
EGK58_RS09950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGK58_RS09955	COG0596	Alpha beta hydrolase
EGK58_RS09965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGK58_RS09970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EGK58_RS09975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGK58_RS10015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EGK58_RS10020	COG3161	chorismate lyase activity
EGK58_RS10030	COG0174	glutamine synthetase
EGK58_RS10035	COG0512	Glutamine amidotransferase of anthranilate synthase
EGK58_RS10040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGK58_RS10065	COG0302	gtp cyclohydrolase
EGK58_RS10080	COG3706	GGDEF domain
EGK58_RS10095	COG3739	integral membrane protein
EGK58_RS10110	COG1741	Belongs to the pirin family
EGK58_RS10145	COG0281	malic enzyme
EGK58_RS10165	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGK58_RS10165	COG1902	pentaerythritol trinitrate reductase activity
EGK58_RS10180	COG3706	GGDEF domain
EGK58_RS10185	COG0418	dihydroorotase activity
EGK58_RS10190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGK58_RS10205	COG0833	amino acid
EGK58_RS10215	COG0833	amino acid
EGK58_RS10255	COG4239	(ABC) transporter, permease
EGK58_RS10260	COG4174	ABC transporter (Permease)
EGK58_RS10265	COG4166	transmembrane transport
EGK58_RS10270	COG0741	lytic transglycosylase activity
EGK58_RS10270	COG1388	LysM domain
EGK58_RS10285	COG2816	NAD+ diphosphatase activity
EGK58_RS10290	COG0657	acetylesterase activity
EGK58_RS10305	COG3107	peptidoglycan biosynthetic process
EGK58_RS10320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGK58_RS10325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGK58_RS10335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGK58_RS10340	COG4372	Transposase
EGK58_RS10350	COG2963	transposase activity
EGK58_RS10360	COG2155	Conserved Protein
EGK58_RS10365	COG0006	proline dipeptidase activity
EGK58_RS10390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGK58_RS10400	COG2234	aminopeptidase activity
EGK58_RS10405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGK58_RS10410	COG3384	dioxygenase
EGK58_RS10420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGK58_RS10425	COG2878	Part of a membrane complex involved in electron transport
EGK58_RS10430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGK58_RS10455	COG0768	penicillin binding
EGK58_RS10460	COG0742	ribosomal rna small subunit methyltransferase
EGK58_RS10505	COG0459	protein refolding
EGK58_RS10520	COG1597	lipid kinase activity
EGK58_RS10530	COG0477	Major facilitator Superfamily
EGK58_RS10545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGK58_RS10570	COG4221	oxidoreductase activity
EGK58_RS10570	COG3321	synthase
EGK58_RS10570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGK58_RS10570	COG0604	alcohol dehydrogenase
EGK58_RS10580	COG3118	belongs to the thioredoxin family
EGK58_RS10610	COG0175	sulfate reduction
EGK58_RS10625	COG2268	Band 7 protein
EGK58_RS10630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGK58_RS10640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGK58_RS10655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGK58_RS10660	COG1053	succinate dehydrogenase
EGK58_RS10665	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EGK58_RS10685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGK58_RS10685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGK58_RS10700	COG0589	response to stress
EGK58_RS10725	COG2321	neutral zinc metallopeptidase
EGK58_RS10730	COG2354	Protein conserved in bacteria
EGK58_RS10755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGK58_RS10760	COG1773	rubredoxin
EGK58_RS10765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGK58_RS10775	COG0583	DNA-binding transcription factor activity
EGK58_RS10790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGK58_RS10800	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EGK58_RS10805	COG4181	ATPase activity
EGK58_RS10830	COG4771	TonB-dependent receptor
EGK58_RS10845	COG4607	ABC-type enterochelin transport system periplasmic component
EGK58_RS10855	COG0306	phosphate transporter
EGK58_RS10870	COG2852	Protein conserved in bacteria
EGK58_RS10885	COG2066	Belongs to the glutaminase family
EGK58_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
EGK58_RS10900	COG0525	valine-tRNA ligase activity
EGK58_RS10930	COG2323	membrane
EGK58_RS10935	COG0546	phosphoglycolate phosphatase activity
EGK58_RS10955	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGK58_RS10970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGK58_RS10975	COG0142	geranyltranstransferase activity
EGK58_RS10980	COG2828	Protein conserved in bacteria
EGK58_RS10985	COG1113	amino acid transport
EGK58_RS11010	COG0560	Phosphoserine phosphatase
EGK58_RS11020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGK58_RS11035	COG0424	maF-like protein
EGK58_RS11040	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EGK58_RS11045	COG1792	Involved in formation and maintenance of cell shape
EGK58_RS11050	COG1077	Cell shape determining protein MreB Mrl
EGK58_RS11055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGK58_RS11065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGK58_RS11095	COG0697	spore germination
EGK58_RS11105	COG3590	peptidase
EGK58_RS11110	COG3590	peptidase
EGK58_RS11120	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EGK58_RS11135	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EGK58_RS11140	COG2223	nitrite transmembrane transporter activity
EGK58_RS11150	COG0500	methyltransferase
EGK58_RS11175	COG0783	Belongs to the Dps family
EGK58_RS11180	COG3706	GGDEF domain
EGK58_RS11190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EGK58_RS11195	COG4149	molybdate abc transporter
EGK58_RS11200	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGK58_RS11205	COG0303	'Molybdopterin
EGK58_RS11210	COG0315	cyclic pyranopterin monophosphate synthase activity
EGK58_RS11210	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGK58_RS11215	COG0314	molybdopterin synthase activity
EGK58_RS11225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EGK58_RS11235	COG0243	molybdopterin cofactor binding
EGK58_RS11240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGK58_RS11245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGK58_RS11250	COG2223	nitrite transmembrane transporter activity
EGK58_RS11265	COG3293	Transposase
EGK58_RS11270	COG0583	DNA-binding transcription factor activity
EGK58_RS11285	COG4771	TonB-dependent receptor
EGK58_RS11300	COG1113	amino acid transport
EGK58_RS11305	COG1448	Aminotransferase
EGK58_RS11320	COG0625	glutathione transferase activity
EGK58_RS11335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EGK58_RS11340	COG0604	alcohol dehydrogenase
EGK58_RS11345	COG3293	Transposase
EGK58_RS11375	COG3177	Filamentation induced by cAMP protein fic
EGK58_RS11395	COG1222	aaa ATPase
EGK58_RS11410	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EGK58_RS11430	COG3293	Transposase
EGK58_RS11480	COG4372	Transposase
EGK58_RS11490	COG2963	transposase activity
EGK58_RS11500	COG0582	viral genome integration into host DNA
EGK58_RS11510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGK58_RS11515	COG2814	Major facilitator Superfamily
EGK58_RS11520	COG1566	PFAM secretion protein HlyD family protein
EGK58_RS11525	COG2050	protein possibly involved in aromatic compounds catabolism
EGK58_RS11535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGK58_RS11540	COG1090	epimerase
EGK58_RS11550	COG0420	3'-5' exonuclease activity
EGK58_RS11580	COG0735	belongs to the Fur family
EGK58_RS11585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGK58_RS11590	COG2914	Belongs to the UPF0125 (RnfH) family
EGK58_RS11605	COG0121	glutamine amidotransferase
EGK58_RS11620	COG2826	transposase and inactivated derivatives, IS30 family
EGK58_RS11625	COG0756	dUTP diphosphatase activity
EGK58_RS11635	COG2885	chlorophyll binding
EGK58_RS11640	COG0204	Acyl-transferase
EGK58_RS11650	COG0850	regulation of cytokinetic process
EGK58_RS11670	COG0531	amino acid
EGK58_RS11670	COG1674	ftsk spoiiie
EGK58_RS11675	COG0492	ferredoxin-NADP+ reductase activity
EGK58_RS11680	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EGK58_RS11690	COG0456	acetyltransferase
EGK58_RS11715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGK58_RS11730	COG1981	membrane
EGK58_RS11735	COG1113	amino acid transport
EGK58_RS11740	COG0251	oxidation-reduction process
EGK58_RS11765	COG0579	oxidoreductase
EGK58_RS11775	COG1652	LysM domain
EGK58_RS11780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGK58_RS11785	COG1028	Short-chain dehydrogenase reductase Sdr
EGK58_RS11795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EGK58_RS11800	COG1399	metal-binding, possibly nucleic acid-binding protein
EGK58_RS11805	COG3101	peptidyl-lysine hydroxylation
EGK58_RS11810	COG0009	L-threonylcarbamoyladenylate synthase
EGK58_RS11825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EGK58_RS11830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGK58_RS11855	COG0339	signal peptide processing
EGK58_RS11865	COG4166	transmembrane transport
EGK58_RS11875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EGK58_RS11895	COG2193	ferroxidase activity
EGK58_RS11900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGK58_RS11905	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EGK58_RS11960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGK58_RS11975	COG1196	nuclear chromosome segregation
EGK58_RS11985	COG0730	response to heat
EGK58_RS12000	COG3545	Serine hydrolase
EGK58_RS12020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGK58_RS12040	COG3327	negative regulation of DNA-templated transcription, initiation
EGK58_RS12045	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EGK58_RS12050	COG0183	Belongs to the thiolase family
EGK58_RS12055	COG1024	Enoyl-CoA hydratase
EGK58_RS12060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGK58_RS12065	COG2151	metal-sulfur cluster biosynthetic enzyme
EGK58_RS12070	COG3396	Phenylacetate-CoA oxygenase
EGK58_RS12075	COG3460	Phenylacetate-CoA oxygenase
EGK58_RS12080	COG3396	Phenylacetate-CoA oxygenase
EGK58_RS12085	COG1012	belongs to the aldehyde dehydrogenase family
EGK58_RS12085	COG2030	dehydratase
EGK58_RS12090	COG2814	Major facilitator Superfamily
EGK58_RS12105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGK58_RS12115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EGK58_RS12130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EGK58_RS12145	COG1968	undecaprenyl-diphosphatase activity
EGK58_RS12150	COG1214	PFAM Peptidase M22, glycoprotease
EGK58_RS12160	COG0494	nUDIX hydrolase
EGK58_RS12185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EGK58_RS12190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EGK58_RS12285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EGK58_RS12290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EGK58_RS12305	COG0450	alkyl hydroperoxide reductase
EGK58_RS12320	COG0285	dihydrofolate synthase activity
EGK58_RS12370	COG4206	TonB-dependent receptor
EGK58_RS12375	COG2096	Adenosyltransferase
EGK58_RS12390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EGK58_RS12420	COG2315	Protein conserved in bacteria
EGK58_RS12430	COG1113	amino acid transport
EGK58_RS12435	COG4372	Transposase
EGK58_RS12445	COG2963	transposase activity
EGK58_RS12455	COG0745	RESPONSE REGULATOR receiver
EGK58_RS12460	COG2205	protein histidine kinase activity
EGK58_RS12470	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS12475	COG1960	acyl-CoA dehydrogenase activity
EGK58_RS12515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGK58_RS12570	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EGK58_RS12575	COG2205	protein histidine kinase activity
EGK58_RS12590	COG1660	Displays ATPase and GTPase activities
EGK58_RS12605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EGK58_RS12610	COG0617	tRNA 3'-terminal CCA addition
EGK58_RS12615	COG1555	photosystem II stabilization
EGK58_RS12615	COG1596	polysaccharide export
EGK58_RS12620	COG3956	TIGRFAM MazG family protein
EGK58_RS12635	COG2826	transposase and inactivated derivatives, IS30 family
EGK58_RS12650	COG0675	Transposase, IS605 OrfB family
EGK58_RS12695	COG1426	Protein conserved in bacteria
EGK58_RS12715	COG2975	iron-sulfur cluster assembly
EGK58_RS12740	COG0028	Belongs to the TPP enzyme family
EGK58_RS12765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGK58_RS12770	COG0577	efflux transmembrane transporter activity
EGK58_RS12770	COG1136	(ABC) transporter
EGK58_RS12775	COG1538	Outer membrane efflux protein
EGK58_RS12785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGK58_RS12795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EGK58_RS12800	COG1162	GTPase activity
EGK58_RS12810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EGK58_RS12830	COG0084	hydrolase, TatD family'
EGK58_RS12845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EGK58_RS12870	COG3706	GGDEF domain
EGK58_RS12870	COG4251	negative regulation of phosphorylation
EGK58_RS12870	COG5001	Diguanylate cyclase
EGK58_RS12870	COG2203	Gaf domain
EGK58_RS12910	COG0793	Belongs to the peptidase S41A family
EGK58_RS12935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGK58_RS12940	COG0857	belongs to the CobB CobQ family
EGK58_RS12940	COG0280	phosphate acetyltransferase
EGK58_RS12950	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EGK58_RS12950	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EGK58_RS12965	COG0740	serine-type endopeptidase activity
EGK58_RS12975	COG4774	siderophore transport
EGK58_RS12985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGK58_RS12990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGK58_RS12995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGK58_RS12995	COG2813	Specifically methylates the guanine in position
EGK58_RS13050	COG3040	lipid binding
EGK58_RS13065	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EGK58_RS13090	COG1196	nuclear chromosome segregation
EGK58_RS13095	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EGK58_RS13140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGK58_RS13265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EGK58_RS13300	COG0788	formyltetrahydrofolate deformylase activity
EGK58_RS13325	COG4651	solute:proton antiporter activity
EGK58_RS13325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EGK58_RS13345	COG0724	RNA recognition motif
EGK58_RS13350	COG0210	DNA helicase
EGK58_RS13355	COG1929	Belongs to the glycerate kinase type-1 family
EGK58_RS13395	COG2900	Belongs to the SlyX family
EGK58_RS13400	COG0488	(ABC) transporter
EGK58_RS13405	COG1560	Kdo2-lipid A biosynthetic process
EGK58_RS13465	COG0473	3-isopropylmalate dehydrogenase activity
EGK58_RS13480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGK58_RS13530	COG0753	catalase activity
EGK58_RS13535	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EGK58_RS13550	COG0519	Catalyzes the synthesis of GMP from XMP
EGK58_RS13565	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGK58_RS13570	COG3384	dioxygenase
EGK58_RS13575	COG1028	Short-chain dehydrogenase reductase Sdr
EGK58_RS13590	COG4638	Rieske (2fe-2S)
EGK58_RS13595	COG0583	DNA-binding transcription factor activity
EGK58_RS13615	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EGK58_RS13620	COG3971	2-oxopent-4-enoate hydratase activity
EGK58_RS13625	COG0546	phosphoglycolate phosphatase activity
EGK58_RS13635	COG1530	ribonuclease E activity
EGK58_RS13640	COG0318	PFAM AMP-dependent synthetase and ligase
EGK58_RS13665	COG1983	PspC domain protein
EGK58_RS13675	COG0471	metal ion transport
EGK58_RS13680	COG0517	IMP dehydrogenase activity
EGK58_RS13680	COG0617	tRNA 3'-terminal CCA addition
EGK58_RS13680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EGK58_RS13690	COG0752	glycyl-tRNA synthetase alpha subunit
EGK58_RS13695	COG0751	glycine-tRNA ligase activity
EGK58_RS13710	COG2826	transposase and inactivated derivatives, IS30 family
EGK58_RS13735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGK58_RS13750	COG2226	methyltransferase
EGK58_RS13770	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EGK58_RS13780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGK58_RS13795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EGK58_RS13805	COG0644	oxidoreductase
EGK58_RS13805	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EGK58_RS13810	COG0425	Belongs to the sulfur carrier protein TusA family
EGK58_RS13815	COG4535	Mg2 and Co2 transporter CorC
EGK58_RS13840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGK58_RS13850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EGK58_RS13875	COG0789	Transcriptional regulator
EGK58_RS13880	COG2841	Protein conserved in bacteria
EGK58_RS13890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGK58_RS13895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGK58_RS13900	COG1074	ATP-dependent DNA helicase activity
EGK58_RS13905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EGK58_RS13925	COG2226	methyltransferase
EGK58_RS13935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGK58_RS13975	COG0427	acetyl-CoA hydrolase
EGK58_RS13980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EGK58_RS14015	COG0326	Molecular chaperone. Has ATPase activity
EGK58_RS14030	COG3047	cAMP biosynthetic process
EGK58_RS14035	COG2056	Na+-H+ antiporter family
EGK58_RS14055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGK58_RS14060	COG0085	RNA polymerase activity
EGK58_RS14075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EGK58_RS14135	COG0546	phosphoglycolate phosphatase activity
EGK58_RS14165	COG0824	Thioesterase
EGK58_RS14195	COG0181	hydroxymethylbilane synthase activity
EGK58_RS14205	COG3275	phosphorelay sensor kinase activity
EGK58_RS14250	COG1024	Enoyl-CoA hydratase
EGK58_RS14250	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGK58_RS14310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EGK58_RS14340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EGK58_RS14375	COG3158	transport of potassium into the cell
EGK58_RS14385	COG0582	viral genome integration into host DNA
EGK58_RS14425	COG0305	Participates in initiation and elongation during chromosome replication
EGK58_RS14455	COG0582	viral genome integration into host DNA
EGK58_RS14490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGK58_RS14535	COG4372	Transposase
EGK58_RS14545	COG2963	transposase activity
EGK58_RS14605	COG0629	single-stranded DNA binding
EGK58_RS14610	COG2814	Major facilitator Superfamily
EGK58_RS14625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EGK58_RS14625	COG0352	thiamine-phosphate diphosphorylase activity
EGK58_RS14625	COG0351	phosphomethylpyrimidine kinase
EGK58_RS14650	COG3706	GGDEF domain
EGK58_RS14655	COG0675	Transposase, IS605 OrfB family
EGK58_RS14670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGK58_RS14680	COG3385	transposase activity
EGK58_RS14685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGK58_RS14690	COG3162	membrane
EGK58_RS14695	COG2205	protein histidine kinase activity
EGK58_RS14695	COG2198	Histidine kinase
EGK58_RS14695	COG0784	Response regulator, receiver
EGK58_RS14710	COG0431	NADPH-dependent FMN reductase
EGK58_RS14720	COG0307	riboflavin synthase, alpha
EGK58_RS14735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGK58_RS14745	COG0668	transmembrane transport
EGK58_RS14750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGK58_RS14755	COG1519	Transferase
EGK58_RS14760	COG1902	pentaerythritol trinitrate reductase activity
EGK58_RS14785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGK58_RS14810	COG0426	domain, Protein
EGK58_RS14810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGK58_RS14815	COG2119	membrane
EGK58_RS14820	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGK58_RS14845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EGK58_RS14855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGK58_RS14865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGK58_RS14880	COG0189	ligase activity
EGK58_RS14905	COG0708	Exodeoxyribonuclease III
EGK58_RS14925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EGK58_RS14980	COG3150	esterase
EGK58_RS14990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EGK58_RS14995	COG2918	glutathione biosynthetic process
EGK58_RS15010	COG2733	membrane
EGK58_RS15050	COG0753	catalase activity
EGK58_RS15070	COG3830	Belongs to the UPF0237 family
EGK58_RS15070	COG0560	Phosphoserine phosphatase
EGK58_RS15085	COG0385	Bile acid
EGK58_RS15090	COG1335	isochorismatase
EGK58_RS15095	COG2814	Major facilitator Superfamily
EGK58_RS15100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGK58_RS15110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGK58_RS15115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EGK58_RS15120	COG3300	MHYT domain
EGK58_RS15120	COG5001	Diguanylate cyclase
EGK58_RS15125	COG2983	Belongs to the UPF0260 family
EGK58_RS15130	COG5487	UPF0391 membrane protein
EGK58_RS15140	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGK58_RS15150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGK58_RS15155	COG1309	transcriptional regulator
EGK58_RS15160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGK58_RS15165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGK58_RS15170	COG0546	phosphoglycolate phosphatase activity
EGK58_RS15175	COG1028	Short-chain dehydrogenase reductase Sdr
EGK58_RS15200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGK58_RS15200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EGK58_RS15205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGK58_RS15210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGK58_RS15215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGK58_RS15220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGK58_RS15225	COG1116	anion transmembrane transporter activity
EGK58_RS15230	COG1309	transcriptional regulator
EGK58_RS15240	COG0196	riboflavin kinase activity
EGK58_RS15245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGK58_RS15255	COG1047	Peptidyl-prolyl cis-trans
EGK58_RS15270	COG2133	pyrroloquinoline quinone binding
EGK58_RS15275	COG5001	Diguanylate cyclase
EGK58_RS15275	COG4251	negative regulation of phosphorylation
EGK58_RS15275	COG3706	GGDEF domain
EGK58_RS15275	COG2203	Gaf domain
EGK58_RS15310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGK58_RS15315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EGK58_RS15320	COG2951	lytic endotransglycosylase activity
EGK58_RS15325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGK58_RS15340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGK58_RS15370	COG2814	Major facilitator Superfamily
EGK58_RS15375	COG0861	Integral membrane protein TerC family
EGK58_RS15380	COG0402	S-adenosylhomocysteine deaminase activity
EGK58_RS15395	COG0675	Transposase, IS605 OrfB family
EGK58_RS15410	COG0675	Transposase, IS605 OrfB family
EGK58_RS15430	COG0706	membrane insertase activity
EGK58_RS15435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGK58_RS15440	COG0594	ribonuclease P activity
EGK58_RS15480	COG1373	ATPase (AAA superfamily
EGK58_RS15515	COG1309	transcriptional regulator
EGK58_RS15530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EGK58_RS15535	COG1335	isochorismatase
EGK58_RS15550	COG3657	addiction module killer protein
EGK58_RS15555	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGK58_RS15565	COG1846	Transcriptional regulator
EGK58_RS15570	COG1764	response to oxidative stress
EGK58_RS15580	COG2801	Transposase and inactivated derivatives
EGK58_RS15625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGK58_RS15630	COG4372	Transposase
EGK58_RS15640	COG2963	transposase activity
EGK58_RS15645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGK58_RS15710	COG2217	Heavy metal translocating P-type atpase
EGK58_RS15715	COG3174	membrane
EGK58_RS15720	COG2205	protein histidine kinase activity
EGK58_RS15735	COG2132	Multicopper oxidase
EGK58_RS15855	COG1846	Transcriptional regulator
EGK58_RS15860	COG1764	response to oxidative stress
EGK58_RS15865	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
EGK58_RS15925	COG3293	Transposase
EGK58_RS15935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGK58_RS15940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EGK58_RS15945	COG0022	dehydrogenase e1 component
EGK58_RS15950	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGK58_RS15955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGK58_RS15965	COG1063	alcohol dehydrogenase
EGK58_RS15980	COG0642	Histidine kinase
EGK58_RS15985	COG0745	RESPONSE REGULATOR receiver
EGK58_RS16005	COG0583	DNA-binding transcription factor activity
EGK58_RS16010	COG0730	response to heat
EGK58_RS16015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGK58_RS16020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGK58_RS16050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGK58_RS16115	COG2130	NADP-dependent
EGK58_RS16120	COG1309	transcriptional regulator
EGK58_RS16130	COG1902	pentaerythritol trinitrate reductase activity
EGK58_RS16140	COG1979	alcohol dehydrogenase
EGK58_RS16155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EGK58_RS16170	COG0604	alcohol dehydrogenase
EGK58_RS16170	COG3321	synthase
EGK58_RS16175	COG1063	alcohol dehydrogenase
EGK58_RS16180	COG0583	DNA-binding transcription factor activity
EGK58_RS16185	COG4221	oxidoreductase activity
EGK58_RS16240	COG4106	trans-aconitate 2-methyltransferase activity
EGK58_RS16275	COG1454	alcohol dehydrogenase
EGK58_RS16295	COG4774	siderophore transport
EGK58_RS16300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EGK58_RS16330	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGK58_RS16340	COG1959	2 iron, 2 sulfur cluster binding
EGK58_RS16350	COG4372	Transposase
EGK58_RS16365	COG0431	NADPH-dependent FMN reductase
EGK58_RS16370	COG0798	PFAM Bile acid sodium symporter
EGK58_RS16375	COG0640	Transcriptional regulator
EGK58_RS16455	COG1192	Involved in chromosome partitioning
EGK58_RS16490	COG1346	cytolysis
EGK58_RS16495	COG1380	Effector of murein hydrolase LrgA
EGK58_RS16500	COG0583	DNA-binding transcription factor activity
EGK58_RS16505	COG1309	transcriptional regulator
EGK58_RS16510	COG0604	alcohol dehydrogenase
EGK58_RS16535	COG3188	usher protein
EGK58_RS16565	COG3077	Addiction module antitoxin, RelB DinJ family
EGK58_RS16605	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGK58_RS16610	COG3657	addiction module killer protein
EGK58_RS16630	COG3173	Aminoglycoside phosphotransferase
EGK58_RS16635	COG0488	(ABC) transporter
EGK58_RS16655	COG2963	transposase activity
EGK58_RS16665	COG4372	Transposase
EGK58_RS16675	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGK58_RS16680	COG3657	addiction module killer protein
EGK58_RS16760	COG1063	alcohol dehydrogenase
EGK58_RS16865	COG2755	lipolytic protein G-D-S-L family
EGK58_RS16865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGK58_RS16875	COG2072	flavoprotein involved in K transport
EGK58_RS16890	COG4591	ABC-type transport system involved in lipoprotein release permease component
EGK58_RS16895	COG1136	(ABC) transporter
EGK58_RS16895	COG0577	efflux transmembrane transporter activity