locus-tag	class	description
I0P84_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I0P84_RS00010	COG0592	DNA-directed DNA polymerase activity
I0P84_RS00020	COG0187	DNA topoisomerase II activity
I0P84_RS00030	COG1063	alcohol dehydrogenase
I0P84_RS00035	COG0488	(ABC) transporter
I0P84_RS00090	COG0657	acetylesterase activity
I0P84_RS00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I0P84_RS00130	COG2814	Major facilitator Superfamily
I0P84_RS00135	COG2814	Major facilitator Superfamily
I0P84_RS00145	COG0666	response to abiotic stimulus
I0P84_RS00150	COG0693	protein deglycase activity
I0P84_RS00160	COG1012	belongs to the aldehyde dehydrogenase family
I0P84_RS00165	COG0733	neurotransmitter:sodium symporter activity
I0P84_RS00175	COG0428	transporter
I0P84_RS00190	COG0129	dihydroxy-acid dehydratase activity
I0P84_RS00195	COG0129	dihydroxy-acid dehydratase activity
I0P84_RS00220	COG2233	PERMEase
I0P84_RS00235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0P84_RS00265	COG0675	Transposase, IS605 OrfB family
I0P84_RS00285	COG2814	Major facilitator Superfamily
I0P84_RS00290	COG0656	L-ascorbic acid biosynthetic process
I0P84_RS00295	COG0583	DNA-binding transcription factor activity
I0P84_RS00300	COG1064	alcohol dehydrogenase
I0P84_RS00305	COG2818	Glycosylase
I0P84_RS00315	COG0739	heme binding
I0P84_RS00320	COG1194	a g-specific adenine glycosylase
I0P84_RS00360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I0P84_RS00365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0P84_RS00385	COG0438	transferase activity, transferring glycosyl groups
I0P84_RS00390	COG0438	transferase activity, transferring glycosyl groups
I0P84_RS00395	COG0438	transferase activity, transferring glycosyl groups
I0P84_RS00405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0P84_RS00415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0P84_RS00430	COG1216	Glycosyl transferase, family 2
I0P84_RS00440	COG0438	transferase activity, transferring glycosyl groups
I0P84_RS00450	COG1086	Polysaccharide biosynthesis protein
I0P84_RS00460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I0P84_RS00470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0P84_RS00475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0P84_RS00490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0P84_RS00500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I0P84_RS00535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I0P84_RS00545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I0P84_RS00550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I0P84_RS00560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I0P84_RS00585	COG4628	conserved protein (DUF2132)
I0P84_RS00605	COG3540	Alkaline phosphatase
I0P84_RS00620	COG0737	Belongs to the 5'-nucleotidase family
I0P84_RS00660	COG3293	Transposase
I0P84_RS00680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I0P84_RS00680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0P84_RS00685	COG1105	Belongs to the carbohydrate kinase PfkB family
I0P84_RS00690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I0P84_RS00690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0P84_RS00690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0P84_RS00695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0P84_RS00700	COG3550	peptidyl-serine autophosphorylation
I0P84_RS00730	COG0753	catalase activity
I0P84_RS00745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0P84_RS00755	COG3756	Protein conserved in bacteria
I0P84_RS00800	COG1192	Involved in chromosome partitioning
I0P84_RS00815	COG0586	Pfam SNARE associated Golgi protein
I0P84_RS00820	COG0519	Catalyzes the synthesis of GMP from XMP
I0P84_RS00820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I0P84_RS00825	COG1715	Restriction endonuclease
I0P84_RS00830	COG3706	GGDEF domain
I0P84_RS00835	COG3706	GGDEF domain
I0P84_RS00885	COG0534	Mate efflux family protein
I0P84_RS00890	COG0436	Aminotransferase
I0P84_RS00910	COG2837	iron assimilation
I0P84_RS00920	COG1683	Conserved Protein
I0P84_RS00925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0P84_RS00930	COG1121	(ABC) transporter
I0P84_RS00980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I0P84_RS00995	COG1012	belongs to the aldehyde dehydrogenase family
I0P84_RS01010	COG0386	Belongs to the glutathione peroxidase family
I0P84_RS01015	COG0386	Belongs to the glutathione peroxidase family
I0P84_RS01020	COG0697	spore germination
I0P84_RS01030	COG0758	DNA mediated transformation
I0P84_RS01080	COG2814	Major facilitator Superfamily
I0P84_RS01100	COG0477	Major facilitator Superfamily
I0P84_RS01105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I0P84_RS01110	COG3757	hydrolase, family 25
I0P84_RS01130	COG1253	flavin adenine dinucleotide binding
I0P84_RS01140	COG2860	membrane
I0P84_RS01145	COG0477	Major facilitator Superfamily
I0P84_RS01155	COG0318	PFAM AMP-dependent synthetase and ligase
I0P84_RS01170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I0P84_RS01260	COG0347	Belongs to the P(II) protein family
I0P84_RS01265	COG0004	ammonium transporteR
I0P84_RS01275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0P84_RS01275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0P84_RS01290	COG0586	Pfam SNARE associated Golgi protein
I0P84_RS01310	COG0795	lipopolysaccharide-transporting ATPase activity
I0P84_RS01315	COG0795	lipopolysaccharide-transporting ATPase activity
I0P84_RS01320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I0P84_RS01325	COG0793	Belongs to the peptidase S41A family
I0P84_RS01335	COG2205	protein histidine kinase activity
I0P84_RS01340	COG2197	response regulator
I0P84_RS01345	COG1686	Belongs to the peptidase S11 family
I0P84_RS01350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I0P84_RS01360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I0P84_RS01365	COG4974	Belongs to the 'phage' integrase family
I0P84_RS01390	COG0772	Belongs to the SEDS family
I0P84_RS01400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I0P84_RS01405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I0P84_RS01410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I0P84_RS01415	COG0494	nUDIX hydrolase
I0P84_RS01430	COG1538	Outer membrane efflux protein
I0P84_RS01440	COG1132	(ABC) transporter
I0P84_RS01450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I0P84_RS01485	COG0497	DNA recombination
I0P84_RS01490	COG3123	guanosine phosphorylase activity
I0P84_RS01495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0P84_RS01505	COG0237	dephospho-CoA kinase activity
I0P84_RS01525	COG0149	triose-phosphate isomerase activity
I0P84_RS01560	COG0779	Required for maturation of 30S ribosomal subunits
I0P84_RS01565	COG0195	Participates in both transcription termination and antitermination
I0P84_RS01575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I0P84_RS01580	COG1320	monovalent cation:proton antiporter activity
I0P84_RS01585	COG2212	antiporter activity
I0P84_RS01590	COG1863	multisubunit Na H antiporter MnhE subunit
I0P84_RS01595	COG0651	ATP synthesis coupled electron transport
I0P84_RS01600	COG1006	Multisubunit Na H antiporter MnhC subunit
I0P84_RS01605	COG2111	Na H antiporter
I0P84_RS01605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0P84_RS01620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I0P84_RS01625	COG4221	oxidoreductase activity
I0P84_RS01635	COG0488	(ABC) transporter
I0P84_RS01645	COG3293	Transposase
I0P84_RS01710	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I0P84_RS01730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I0P84_RS01735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I0P84_RS01740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I0P84_RS01745	COG2226	methyltransferase
I0P84_RS01795	COG0067	glutamate synthase
I0P84_RS01795	COG0070	glutamate synthase
I0P84_RS01795	COG0069	glutamate synthase activity
I0P84_RS01800	COG0493	'glutamate synthase
I0P84_RS01805	COG1704	LemA family
I0P84_RS01865	COG4969	Belongs to the N-Me-Phe pilin family
I0P84_RS01875	COG3307	-O-antigen
I0P84_RS01895	COG0675	Transposase, IS605 OrfB family
I0P84_RS01900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0P84_RS01905	COG1758	RNA polymerase activity
I0P84_RS01910	COG0194	GDP metabolic process
I0P84_RS01920	COG4969	Belongs to the N-Me-Phe pilin family
I0P84_RS01955	COG0228	four-way junction DNA binding
I0P84_RS01960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I0P84_RS01970	COG0335	large ribosomal subunit rRNA binding
I0P84_RS01980	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I0P84_RS01985	COG5380	lipid catabolic process
I0P84_RS01990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I0P84_RS02020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0P84_RS02025	COG0277	FAD linked oxidase domain protein
I0P84_RS02045	COG2814	Major facilitator Superfamily
I0P84_RS02050	COG1289	transmembrane transporter activity
I0P84_RS02060	COG0628	permease
I0P84_RS02080	COG2226	methyltransferase
I0P84_RS02095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I0P84_RS02100	COG0254	rRNA binding
I0P84_RS02105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I0P84_RS02115	COG0534	Mate efflux family protein
I0P84_RS02125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0P84_RS02135	COG1278	Cold shock
I0P84_RS02140	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS02155	COG0408	coproporphyrinogen oxidase activity
I0P84_RS02160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0P84_RS02170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I0P84_RS02180	COG0513	Belongs to the DEAD box helicase family
I0P84_RS02185	COG1127	ABC transporter
I0P84_RS02190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I0P84_RS02195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I0P84_RS02200	COG2854	intermembrane phospholipid transfer
I0P84_RS02210	COG0598	Magnesium transport protein CorA
I0P84_RS02225	COG1040	competence protein
I0P84_RS02230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I0P84_RS02245	COG2937	Belongs to the GPAT DAPAT family
I0P84_RS02250	COG1946	Acyl-CoA thioesterase
I0P84_RS02255	COG1301	dicarboxylic acid transport
I0P84_RS02275	COG1959	2 iron, 2 sulfur cluster binding
I0P84_RS02285	COG0433	COG0433 Predicted ATPase
I0P84_RS02290	COG0626	cystathionine gamma-synthase activity
I0P84_RS02305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I0P84_RS02310	COG0088	Forms part of the polypeptide exit tunnel
I0P84_RS02325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I0P84_RS02370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I0P84_RS02375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I0P84_RS02380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I0P84_RS02390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I0P84_RS02415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I0P84_RS02425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I0P84_RS02430	COG0202	RNA polymerase activity
I0P84_RS02435	COG0203	ribosomal protein L17
I0P84_RS02440	COG2072	flavoprotein involved in K transport
I0P84_RS02445	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS02450	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I0P84_RS02475	COG0697	spore germination
I0P84_RS02485	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I0P84_RS02490	COG0339	signal peptide processing
I0P84_RS02500	COG0557	exoribonuclease II activity
I0P84_RS02540	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0P84_RS02550	COG1295	ribonuclease BN
I0P84_RS02600	COG1702	phosphate starvation-inducible protein PhoH
I0P84_RS02605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0P84_RS02610	COG0739	heme binding
I0P84_RS02610	COG0741	lytic transglycosylase activity
I0P84_RS02610	COG1196	nuclear chromosome segregation
I0P84_RS02650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I0P84_RS02655	COG1183	phosphatidylcholine synthase activity
I0P84_RS02690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0P84_RS02715	COG1607	acyl-coa hydrolase
I0P84_RS02745	COG2350	Protein conserved in bacteria
I0P84_RS02760	COG3781	membrane
I0P84_RS02765	COG2003	Belongs to the UPF0758 family
I0P84_RS02770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0P84_RS02780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0P84_RS02890	COG1802	Transcriptional regulator
I0P84_RS02890	COG4626	Terminase
I0P84_RS03010	COG2814	Major facilitator Superfamily
I0P84_RS03040	COG3622	Belongs to the hyi family
I0P84_RS03045	COG2084	Dehydrogenase
I0P84_RS03055	COG0784	Response regulator, receiver
I0P84_RS03055	COG5002	protein histidine kinase activity
I0P84_RS03055	COG2205	protein histidine kinase activity
I0P84_RS03060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0P84_RS03075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0P84_RS03085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0P84_RS03095	COG1862	Preprotein translocase
I0P84_RS03110	COG1704	LemA family
I0P84_RS03120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I0P84_RS03130	COG0318	PFAM AMP-dependent synthetase and ligase
I0P84_RS03175	COG0625	glutathione transferase activity
I0P84_RS03185	COG1238	metal cluster binding
I0P84_RS03215	COG0072	phenylalanine-tRNA ligase activity
I0P84_RS03240	COG0248	Ppx GppA phosphatase
I0P84_RS03250	COG0037	tRNA processing
I0P84_RS03290	COG1764	response to oxidative stress
I0P84_RS03295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0P84_RS03365	COG2969	positive regulation of protein catabolic process
I0P84_RS03370	COG0625	glutathione transferase activity
I0P84_RS03375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I0P84_RS03380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I0P84_RS03385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I0P84_RS03390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I0P84_RS03395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I0P84_RS03425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0P84_RS03435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0P84_RS03440	COG1408	metallophosphoesterase
I0P84_RS03450	COG0477	Major facilitator Superfamily
I0P84_RS03455	COG1272	protein, Hemolysin III
I0P84_RS03475	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0P84_RS03475	COG1024	Enoyl-CoA hydratase
I0P84_RS03480	COG0183	Belongs to the thiolase family
I0P84_RS03485	COG2207	Transcriptional regulator
I0P84_RS03490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I0P84_RS03495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0P84_RS03510	COG0183	Belongs to the thiolase family
I0P84_RS03530	COG0833	amino acid
I0P84_RS03540	COG2233	PERMEase
I0P84_RS03545	COG1217	gtp-binding protein TYPA
I0P84_RS03570	COG1902	pentaerythritol trinitrate reductase activity
I0P84_RS03585	COG0354	folic acid binding
I0P84_RS03590	COG2132	Multicopper oxidase
I0P84_RS03595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I0P84_RS03640	COG0564	pseudouridine synthase activity
I0P84_RS03670	COG2824	Alkylphosphonate utilization operon protein PhnA
I0P84_RS03690	COG0351	phosphomethylpyrimidine kinase
I0P84_RS03690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0P84_RS03690	COG0352	thiamine-phosphate diphosphorylase activity
I0P84_RS03720	COG3152	Membrane
I0P84_RS03730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I0P84_RS03740	COG0745	RESPONSE REGULATOR receiver
I0P84_RS03745	COG2205	protein histidine kinase activity
I0P84_RS03755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0P84_RS03775	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I0P84_RS03790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0P84_RS03795	COG0839	Belongs to the complex I subunit 6 family
I0P84_RS03800	COG0713	ATP synthesis coupled electron transport
I0P84_RS03805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0P84_RS03810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0P84_RS03835	COG1278	Cold shock
I0P84_RS03840	COG0583	DNA-binding transcription factor activity
I0P84_RS03860	COG0668	transmembrane transport
I0P84_RS03875	COG2081	HI0933 family
I0P84_RS03900	COG0004	ammonium transporteR
I0P84_RS03905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0P84_RS03915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0P84_RS03915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0P84_RS03925	COG0489	protein tyrosine kinase activity
I0P84_RS03940	COG2358	TRAP transporter, solute receptor (TAXI family
I0P84_RS04010	COG0840	transmembrane signaling receptor activity
I0P84_RS04040	COG2832	Protein of unknown function (DUF454)
I0P84_RS04100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I0P84_RS04110	COG1289	transmembrane transporter activity
I0P84_RS04115	COG2814	Major facilitator Superfamily
I0P84_RS04125	COG0786	glutamate:sodium symporter activity
I0P84_RS04130	COG1115	amino acid carrier protein
I0P84_RS04135	COG2059	Chromate
I0P84_RS04140	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0P84_RS04150	COG1607	acyl-coa hydrolase
I0P84_RS04170	COG0625	glutathione transferase activity
I0P84_RS04185	COG0523	cobalamin synthesis protein
I0P84_RS04195	COG1285	pathogenesis
I0P84_RS04205	COG2199	diguanylate cyclase activity
I0P84_RS04205	COG2203	Gaf domain
I0P84_RS04250	COG0393	Putative heavy-metal-binding
I0P84_RS04255	COG0393	Putative heavy-metal-binding
I0P84_RS04260	COG1538	Outer membrane efflux protein
I0P84_RS04270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0P84_RS04275	COG0671	phosphoesterase, PA-phosphatase related
I0P84_RS04290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I0P84_RS04300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I0P84_RS04310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I0P84_RS04315	COG1648	precorrin-2 dehydrogenase activity
I0P84_RS04315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I0P84_RS04320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I0P84_RS04330	COG0531	amino acid
I0P84_RS04345	COG0321	lipoyl(octanoyl) transferase activity
I0P84_RS04355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0P84_RS04375	COG0586	Pfam SNARE associated Golgi protein
I0P84_RS04430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I0P84_RS04460	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I0P84_RS04470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I0P84_RS04475	COG0358	DNA primase activity
I0P84_RS04485	COG0564	pseudouridine synthase activity
I0P84_RS04510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I0P84_RS04530	COG0110	maltose O-acetyltransferase activity
I0P84_RS04535	COG0251	oxidation-reduction process
I0P84_RS04540	COG1309	transcriptional regulator
I0P84_RS04550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I0P84_RS04555	COG0505	Belongs to the CarA family
I0P84_RS04580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I0P84_RS04585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I0P84_RS04595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I0P84_RS04630	COG1253	flavin adenine dinucleotide binding
I0P84_RS04655	COG2239	Acts as a magnesium transporter
I0P84_RS04665	COG0501	Belongs to the peptidase M48B family
I0P84_RS04670	COG1196	nuclear chromosome segregation
I0P84_RS04670	COG0739	heme binding
I0P84_RS04670	COG0741	lytic transglycosylase activity
I0P84_RS04675	COG0037	tRNA processing
I0P84_RS04685	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I0P84_RS04690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I0P84_RS04700	COG0583	DNA-binding transcription factor activity
I0P84_RS04705	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS04715	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I0P84_RS04740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I0P84_RS04745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I0P84_RS04750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I0P84_RS04760	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I0P84_RS04780	COG1115	amino acid carrier protein
I0P84_RS04785	COG1113	amino acid transport
I0P84_RS04805	COG0596	Alpha beta hydrolase
I0P84_RS04810	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I0P84_RS04820	COG1522	sequence-specific DNA binding
I0P84_RS04825	COG1280	lysine exporter protein (LysE YggA)
I0P84_RS04885	COG1671	Belongs to the UPF0178 family
I0P84_RS04905	COG1136	(ABC) transporter
I0P84_RS04910	COG0658	competence protein
I0P84_RS04910	COG2333	competence protein COMEC
I0P84_RS04925	COG2267	carboxylic ester hydrolase activity
I0P84_RS04930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I0P84_RS04935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I0P84_RS04940	COG0628	permease
I0P84_RS04945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I0P84_RS04975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0P84_RS04995	COG0823	Involved in the tonB-independent uptake of proteins
I0P84_RS05015	COG0824	Thioesterase
I0P84_RS05020	COG1473	amidohydrolase
I0P84_RS05025	COG2255	four-way junction helicase activity
I0P84_RS05045	COG3293	Transposase
I0P84_RS05055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I0P84_RS05055	COG0047	phosphoribosylformylglycinamidine synthase activity
I0P84_RS05085	COG0778	Nitroreductase
I0P84_RS05090	COG1024	Enoyl-CoA hydratase
I0P84_RS05095	COG1051	belongs to the nudix hydrolase family
I0P84_RS05095	COG1056	cytidyltransferase-related domain
I0P84_RS05100	COG2353	YceI-like domain
I0P84_RS05105	COG0583	DNA-binding transcription factor activity
I0P84_RS05110	COG1279	arginine transmembrane transporter activity
I0P84_RS05115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I0P84_RS05125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I0P84_RS05130	COG0602	queuosine metabolic process
I0P84_RS05150	COG0583	DNA-binding transcription factor activity
I0P84_RS05155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I0P84_RS05160	COG4208	sulfate ABC transporter
I0P84_RS05165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I0P84_RS05175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I0P84_RS05180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I0P84_RS05190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I0P84_RS05210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0P84_RS05235	COG0571	ribonuclease III activity
I0P84_RS05240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I0P84_RS05250	COG1381	Involved in DNA repair and RecF pathway recombination
I0P84_RS05255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I0P84_RS05290	COG0436	Aminotransferase
I0P84_RS05300	COG0052	Belongs to the universal ribosomal protein uS2 family
I0P84_RS05325	COG2951	lytic endotransglycosylase activity
I0P84_RS05340	COG0842	Transport permease protein
I0P84_RS05345	COG1131	(ABC) transporter
I0P84_RS05420	COG3634	alkyl hydroperoxide reductase activity
I0P84_RS05425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I0P84_RS05430	COG0826	peptidase U32
I0P84_RS05455	COG4993	Dehydrogenase
I0P84_RS05465	COG1720	tRNA m6t6A37 methyltransferase activity
I0P84_RS05480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I0P84_RS05495	COG0642	Histidine kinase
I0P84_RS05505	COG0494	nUDIX hydrolase
I0P84_RS05515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0P84_RS05520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I0P84_RS05525	COG3139	Protein of unknown function (DUF1315)
I0P84_RS05535	COG1301	dicarboxylic acid transport
I0P84_RS05555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0P84_RS05560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I0P84_RS05590	COG2252	PERMEase
I0P84_RS05595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I0P84_RS05610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I0P84_RS05620	COG0527	aspartate kinase activity
I0P84_RS05625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I0P84_RS05630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0P84_RS05655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I0P84_RS05660	COG0501	Belongs to the peptidase M48B family
I0P84_RS05680	COG1252	NADH dehydrogenase
I0P84_RS05685	COG1686	Belongs to the peptidase S11 family
I0P84_RS05700	COG2351	hydroxyisourate hydrolase activity
I0P84_RS05720	COG1187	pseudouridine synthase activity
I0P84_RS05750	COG0436	Aminotransferase
I0P84_RS05755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0P84_RS05760	COG0386	Belongs to the glutathione peroxidase family
I0P84_RS05770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I0P84_RS05785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I0P84_RS05795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0P84_RS05800	COG0012	GTP binding
I0P84_RS05805	COG2011	ABC-type metal ion transport system permease component
I0P84_RS05810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I0P84_RS05815	COG1464	Belongs to the NlpA lipoprotein family
I0P84_RS05905	COG0582	viral genome integration into host DNA
I0P84_RS05915	COG2801	Transposase and inactivated derivatives
I0P84_RS05925	COG1113	amino acid transport
I0P84_RS05935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0P84_RS05940	COG1012	belongs to the aldehyde dehydrogenase family
I0P84_RS05990	COG1522	sequence-specific DNA binding
I0P84_RS05995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I0P84_RS06005	COG3138	arginine N-succinyltransferase
I0P84_RS06010	COG1012	belongs to the aldehyde dehydrogenase family
I0P84_RS06015	COG3724	N-succinylarginine dihydrolase activity
I0P84_RS06025	COG1113	amino acid transport
I0P84_RS06100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I0P84_RS06100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I0P84_RS06105	COG1254	Belongs to the acylphosphatase family
I0P84_RS06140	COG3634	alkyl hydroperoxide reductase activity
I0P84_RS06165	COG1643	Atp-dependent helicase
I0P84_RS06185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I0P84_RS06190	COG2707	UPF0756 membrane protein
I0P84_RS06215	COG0802	atpase or kinase
I0P84_RS06220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I0P84_RS06230	COG1923	regulation of RNA biosynthetic process
I0P84_RS06235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0P84_RS06245	COG3178	'Phosphotransferase
I0P84_RS06250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I0P84_RS06260	COG1192	Involved in chromosome partitioning
I0P84_RS06265	COG1475	DNA binding
I0P84_RS06270	COG0811	peptide transport
I0P84_RS06280	COG1132	(ABC) transporter
I0P84_RS06285	COG1663	tetraacyldisaccharide 4'-kinase activity
I0P84_RS06305	COG0084	hydrolase, TatD family'
I0P84_RS06310	COG1309	transcriptional regulator
I0P84_RS06340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I0P84_RS06370	COG0776	regulation of translation
I0P84_RS06390	COG2431	L-lysine efflux transmembrane transporter activity
I0P84_RS06405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I0P84_RS06430	COG1253	flavin adenine dinucleotide binding
I0P84_RS06435	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I0P84_RS06450	COG0308	aminopeptidase N
I0P84_RS06460	COG0589	response to stress
I0P84_RS06465	COG0589	response to stress
I0P84_RS06480	COG3135	benzoate transporter
I0P84_RS06490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I0P84_RS06505	COG0183	Belongs to the thiolase family
I0P84_RS06530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I0P84_RS06535	COG0824	Thioesterase
I0P84_RS06540	COG1454	alcohol dehydrogenase
I0P84_RS06545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I0P84_RS06565	COG0069	glutamate synthase activity
I0P84_RS06575	COG2308	Evidence 4 Homologs of previously reported genes of
I0P84_RS06585	COG1305	Transglutaminase-like
I0P84_RS06600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0P84_RS06605	COG0305	Participates in initiation and elongation during chromosome replication
I0P84_RS06620	COG0360	Binds together with S18 to 16S ribosomal RNA
I0P84_RS06630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I0P84_RS06635	COG1845	cytochrome c oxidase, subunit III
I0P84_RS06640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0P84_RS06645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0P84_RS06670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0P84_RS06685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I0P84_RS06690	COG2890	protein-(glutamine-N5) methyltransferase activity
I0P84_RS06695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0P84_RS06700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0P84_RS06720	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS06725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0P84_RS06740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0P84_RS06750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I0P84_RS06770	COG0477	Major facilitator Superfamily
I0P84_RS06775	COG0729	surface antigen
I0P84_RS06930	COG5410	chromosome segregation
I0P84_RS07090	COG1570	exodeoxyribonuclease VII activity
I0P84_RS07125	COG0786	glutamate:sodium symporter activity
I0P84_RS07150	COG0024	Methionine aminopeptidase
I0P84_RS07155	COG0583	DNA-binding transcription factor activity
I0P84_RS07160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I0P84_RS07175	COG1902	pentaerythritol trinitrate reductase activity
I0P84_RS07175	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0P84_RS07205	COG0148	phosphopyruvate hydratase activity
I0P84_RS07220	COG0772	Belongs to the SEDS family
I0P84_RS07235	COG4890	Cyd operon protein YbgT
I0P84_RS07240	COG1294	oxidase, subunit
I0P84_RS07290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I0P84_RS07310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I0P84_RS07320	COG0133	tryptophan synthase activity
I0P84_RS07325	COG0517	IMP dehydrogenase activity
I0P84_RS07325	COG0516	GMP reductase activity
I0P84_RS07355	COG0612	Peptidase, M16
I0P84_RS07360	COG0552	protein localization to endoplasmic reticulum
I0P84_RS07415	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS07485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I0P84_RS07490	COG0730	response to heat
I0P84_RS07495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0P84_RS07500	COG2207	Transcriptional regulator
I0P84_RS07505	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0P84_RS07510	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS07525	COG1476	TRANSCRIPTIONal
I0P84_RS07540	COG1271	oxidase subunit
I0P84_RS07545	COG1294	oxidase, subunit
I0P84_RS07555	COG1525	nuclease
I0P84_RS07610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0P84_RS07615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I0P84_RS07625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I0P84_RS07640	COG2814	Major facilitator Superfamily
I0P84_RS07645	COG0509	glycine decarboxylation via glycine cleavage system
I0P84_RS07655	COG1132	(ABC) transporter
I0P84_RS07660	COG0668	transmembrane transport
I0P84_RS07665	COG3122	Protein conserved in bacteria
I0P84_RS07685	COG0640	Transcriptional regulator
I0P84_RS07690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0P84_RS07700	COG0789	Transcriptional regulator
I0P84_RS07715	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS07720	COG0183	Belongs to the thiolase family
I0P84_RS07745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I0P84_RS07750	COG0183	Belongs to the thiolase family
I0P84_RS07755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0P84_RS07760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I0P84_RS07765	COG3135	benzoate transporter
I0P84_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS07775	COG0543	2 iron, 2 sulfur cluster binding
I0P84_RS07775	COG0633	Ferredoxin
I0P84_RS07780	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I0P84_RS07785	COG4638	Rieske (2fe-2S)
I0P84_RS07795	COG4829	muconolactone delta-isomerase
I0P84_RS07800	COG4948	Mandelate Racemase Muconate Lactonizing
I0P84_RS07805	COG0583	DNA-binding transcription factor activity
I0P84_RS07810	COG2814	Major facilitator Superfamily
I0P84_RS07820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0P84_RS07830	COG0318	PFAM AMP-dependent synthetase and ligase
I0P84_RS07850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0P84_RS07865	COG0439	Biotin carboxylase
I0P84_RS07885	COG2885	chlorophyll binding
I0P84_RS07885	COG3047	cAMP biosynthetic process
I0P84_RS07890	COG0864	Transcriptional regulator
I0P84_RS07900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0P84_RS07925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0P84_RS07930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0P84_RS07935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0P84_RS07935	COG1116	anion transmembrane transporter activity
I0P84_RS07950	COG4771	TonB-dependent receptor
I0P84_RS07960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0P84_RS07965	COG1309	transcriptional regulator
I0P84_RS07985	COG1944	ATP diphosphatase activity
I0P84_RS07995	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS08000	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS08005	COG2814	Major facilitator Superfamily
I0P84_RS08010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I0P84_RS08015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0P84_RS08025	COG2814	Major facilitator Superfamily
I0P84_RS08035	COG2814	Major facilitator Superfamily
I0P84_RS08045	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0P84_RS08050	COG0183	Belongs to the thiolase family
I0P84_RS08060	COG0235	Class ii aldolase
I0P84_RS08065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0P84_RS08070	COG1024	Enoyl-CoA hydratase
I0P84_RS08080	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS08095	COG0318	PFAM AMP-dependent synthetase and ligase
I0P84_RS08100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I0P84_RS08105	COG2814	Major facilitator Superfamily
I0P84_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS08120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I0P84_RS08130	COG0318	PFAM AMP-dependent synthetase and ligase
I0P84_RS08145	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS08160	COG1136	(ABC) transporter
I0P84_RS08165	COG0640	Transcriptional regulator
I0P84_RS08190	COG2132	Multicopper oxidase
I0P84_RS08215	COG4773	Receptor
I0P84_RS08220	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I0P84_RS08225	COG2116	formate transmembrane transporter activity
I0P84_RS08230	COG0515	serine threonine protein kinase
I0P84_RS08250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I0P84_RS08255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0P84_RS08275	COG0583	DNA-binding transcription factor activity
I0P84_RS08285	COG1289	transmembrane transporter activity
I0P84_RS08310	COG4772	TonB-dependent receptor
I0P84_RS08330	COG0402	S-adenosylhomocysteine deaminase activity
I0P84_RS08335	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0P84_RS08345	COG3845	ABC transporter
I0P84_RS08365	COG0583	DNA-binding transcription factor activity
I0P84_RS08375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0P84_RS08380	COG4266	Belongs to the allantoicase family
I0P84_RS08395	COG2233	PERMEase
I0P84_RS08400	COG2351	hydroxyisourate hydrolase activity
I0P84_RS08420	COG0804	urea catabolic process
I0P84_RS08450	COG0830	nickel cation binding
I0P84_RS08490	COG0596	Alpha beta hydrolase
I0P84_RS08530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0P84_RS08565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I0P84_RS08580	COG0439	Biotin carboxylase
I0P84_RS08590	COG3706	GGDEF domain
I0P84_RS08640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I0P84_RS08650	COG5499	transcription regulator containing HTH domain
I0P84_RS08655	COG4680	protein conserved in bacteria
I0P84_RS08695	COG1058	Belongs to the CinA family
I0P84_RS08695	COG1546	Belongs to the CinA family
I0P84_RS08705	COG0372	Belongs to the citrate synthase family
I0P84_RS08735	COG0542	response to heat
I0P84_RS08740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I0P84_RS08760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I0P84_RS08765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0P84_RS08770	COG0569	domain protein
I0P84_RS08775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0P84_RS08795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0P84_RS08805	COG1585	Membrane protein implicated in regulation of membrane protease activity
I0P84_RS08825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0P84_RS08845	COG1959	2 iron, 2 sulfur cluster binding
I0P84_RS08855	COG0822	iron-sulfur transferase activity
I0P84_RS08860	COG0316	Belongs to the HesB IscA family
I0P84_RS08890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I0P84_RS08900	COG1027	Aspartate ammonia-lyase
I0P84_RS08915	COG0506	proline dehydrogenase activity
I0P84_RS08915	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I0P84_RS08915	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I0P84_RS08940	COG3781	membrane
I0P84_RS08945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I0P84_RS08985	COG0697	spore germination
I0P84_RS09010	COG0424	maF-like protein
I0P84_RS09015	COG2850	peptidyl-arginine hydroxylation
I0P84_RS09020	COG4585	Histidine kinase
I0P84_RS09025	COG2197	response regulator
I0P84_RS09035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I0P84_RS09040	COG0702	epimerase
I0P84_RS09045	COG0268	Binds directly to 16S ribosomal RNA
I0P84_RS09060	COG1011	Hydrolase
I0P84_RS09065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I0P84_RS09075	COG2137	regulation of response to DNA damage stimulus
I0P84_RS09095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0P84_RS09100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0P84_RS09115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I0P84_RS09130	COG0575	Belongs to the CDS family
I0P84_RS09135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I0P84_RS09155	COG3852	Histidine kinase
I0P84_RS09170	COG0445	tRNA wobble uridine modification
I0P84_RS09200	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I0P84_RS09205	COG0138	bifunctional purine biosynthesis protein purh
I0P84_RS09220	COG1464	Belongs to the NlpA lipoprotein family
I0P84_RS09225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I0P84_RS09230	COG2011	ABC-type metal ion transport system permease component
I0P84_RS09265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I0P84_RS09275	COG4122	O-methyltransferase activity
I0P84_RS09310	COG1137	ATPase activity
I0P84_RS09315	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I0P84_RS09325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I0P84_RS09330	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I0P84_RS09330	COG0517	IMP dehydrogenase activity
I0P84_RS09380	COG0505	Belongs to the CarA family
I0P84_RS09400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I0P84_RS09420	COG2391	methyltransferase activity
I0P84_RS09480	COG2267	carboxylic ester hydrolase activity
I0P84_RS09520	COG0352	thiamine-phosphate diphosphorylase activity
I0P84_RS09535	COG3025	triphosphatase activity
I0P84_RS09555	COG0612	Peptidase, M16
I0P84_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0P84_RS09640	COG2203	Gaf domain
I0P84_RS09640	COG2199	diguanylate cyclase activity
I0P84_RS09655	COG1610	YqeY-like protein
I0P84_RS09670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0P84_RS09720	COG0778	Nitroreductase
I0P84_RS09730	COG0513	Belongs to the DEAD box helicase family
I0P84_RS09750	COG2363	Small membrane protein
I0P84_RS09775	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0P84_RS09785	COG0659	secondary active sulfate transmembrane transporter activity
I0P84_RS09790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I0P84_RS09810	COG0318	PFAM AMP-dependent synthetase and ligase
I0P84_RS09815	COG1309	transcriptional regulator
I0P84_RS09820	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS09825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I0P84_RS09830	COG1024	Enoyl-CoA hydratase
I0P84_RS09835	COG4770	biotin carboxylase activity
I0P84_RS09850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0P84_RS09855	COG2031	fatty acid transporter
I0P84_RS09870	COG0540	Belongs to the ATCase OTCase family
I0P84_RS09895	COG0667	Aldo Keto reductase
I0P84_RS09905	COG1765	OsmC-like protein
I0P84_RS09910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I0P84_RS09920	COG3293	Transposase
I0P84_RS09940	COG0714	Associated with various cellular activities
I0P84_RS09945	COG2879	small protein
I0P84_RS09950	COG1966	Carbon starvation protein
I0P84_RS09955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I0P84_RS09995	COG1067	ATP-dependent peptidase activity
I0P84_RS10000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I0P84_RS10005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0P84_RS10010	COG0583	DNA-binding transcription factor activity
I0P84_RS10035	COG1686	Belongs to the peptidase S11 family
I0P84_RS10040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I0P84_RS10055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I0P84_RS10055	COG2755	lipolytic protein G-D-S-L family
I0P84_RS10065	COG0482	sulfurtransferase activity
I0P84_RS10095	COG0616	signal peptide processing
I0P84_RS10105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I0P84_RS10115	COG0573	inorganic phosphate transmembrane transporter activity
I0P84_RS10120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0P84_RS10125	COG1113	amino acid transport
I0P84_RS10130	COG3961	Belongs to the TPP enzyme family
I0P84_RS10135	COG1522	sequence-specific DNA binding
I0P84_RS10140	COG1012	belongs to the aldehyde dehydrogenase family
I0P84_RS10150	COG0076	glutamate decarboxylase activity
I0P84_RS10155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0P84_RS10165	COG0671	phosphoesterase, PA-phosphatase related
I0P84_RS10190	COG1733	regulation of RNA biosynthetic process
I0P84_RS10205	COG3040	lipid binding
I0P84_RS10210	COG0556	nucleotide-excision repair
I0P84_RS10250	COG2721	sulfolactate sulfo-lyase activity
I0P84_RS10265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I0P84_RS10270	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS10280	COG2084	Dehydrogenase
I0P84_RS10285	COG2233	PERMEase
I0P84_RS10290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0P84_RS10295	COG0251	oxidation-reduction process
I0P84_RS10300	COG1335	isochorismatase
I0P84_RS10305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0P84_RS10310	COG0596	Alpha beta hydrolase
I0P84_RS10320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0P84_RS10325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I0P84_RS10330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0P84_RS10360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I0P84_RS10375	COG0174	glutamine synthetase
I0P84_RS10380	COG3293	Transposase
I0P84_RS10385	COG0512	Glutamine amidotransferase of anthranilate synthase
I0P84_RS10390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I0P84_RS10405	COG0302	gtp cyclohydrolase
I0P84_RS10420	COG3706	GGDEF domain
I0P84_RS10435	COG3739	integral membrane protein
I0P84_RS10450	COG1741	Belongs to the pirin family
I0P84_RS10465	COG1546	Belongs to the CinA family
I0P84_RS10465	COG1058	Belongs to the CinA family
I0P84_RS10485	COG0281	malic enzyme
I0P84_RS10530	COG1785	Belongs to the alkaline phosphatase family
I0P84_RS10535	COG1785	Belongs to the alkaline phosphatase family
I0P84_RS10555	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0P84_RS10555	COG1902	pentaerythritol trinitrate reductase activity
I0P84_RS10570	COG3706	GGDEF domain
I0P84_RS10575	COG0418	dihydroorotase activity
I0P84_RS10580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I0P84_RS10595	COG0833	amino acid
I0P84_RS10605	COG0833	amino acid
I0P84_RS10645	COG4239	(ABC) transporter, permease
I0P84_RS10650	COG4174	ABC transporter (Permease)
I0P84_RS10655	COG4166	transmembrane transport
I0P84_RS10660	COG1388	LysM domain
I0P84_RS10660	COG0741	lytic transglycosylase activity
I0P84_RS10675	COG2816	NAD+ diphosphatase activity
I0P84_RS10680	COG0657	acetylesterase activity
I0P84_RS10695	COG3107	peptidoglycan biosynthetic process
I0P84_RS10710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0P84_RS10715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0P84_RS10730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I0P84_RS10735	COG2155	Conserved Protein
I0P84_RS10740	COG0006	proline dipeptidase activity
I0P84_RS10765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I0P84_RS10775	COG2234	aminopeptidase activity
I0P84_RS10780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I0P84_RS10785	COG3384	dioxygenase
I0P84_RS10795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I0P84_RS10800	COG2878	Part of a membrane complex involved in electron transport
I0P84_RS10805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I0P84_RS10830	COG0768	penicillin binding
I0P84_RS10835	COG0742	ribosomal rna small subunit methyltransferase
I0P84_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS10880	COG0459	protein refolding
I0P84_RS10895	COG1597	lipid kinase activity
I0P84_RS10905	COG0477	Major facilitator Superfamily
I0P84_RS10920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I0P84_RS10945	COG4221	oxidoreductase activity
I0P84_RS10945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I0P84_RS10945	COG3321	synthase
I0P84_RS10945	COG0604	alcohol dehydrogenase
I0P84_RS10955	COG3118	belongs to the thioredoxin family
I0P84_RS11000	COG2268	Band 7 protein
I0P84_RS11005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0P84_RS11015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0P84_RS11030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I0P84_RS11035	COG1053	succinate dehydrogenase
I0P84_RS11040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I0P84_RS11060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0P84_RS11060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I0P84_RS11075	COG0589	response to stress
I0P84_RS11095	COG2321	neutral zinc metallopeptidase
I0P84_RS11100	COG2354	Protein conserved in bacteria
I0P84_RS11125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I0P84_RS11130	COG1773	rubredoxin
I0P84_RS11135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0P84_RS11145	COG0583	DNA-binding transcription factor activity
I0P84_RS11160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0P84_RS11170	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I0P84_RS11175	COG4181	ATPase activity
I0P84_RS11200	COG4771	TonB-dependent receptor
I0P84_RS11215	COG4607	ABC-type enterochelin transport system periplasmic component
I0P84_RS11225	COG0306	phosphate transporter
I0P84_RS11260	COG2376	Dihydroxyacetone kinase
I0P84_RS11265	COG2066	Belongs to the glutaminase family
I0P84_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS11280	COG0525	valine-tRNA ligase activity
I0P84_RS11295	COG3293	Transposase
I0P84_RS11315	COG2323	membrane
I0P84_RS11320	COG0546	phosphoglycolate phosphatase activity
I0P84_RS11340	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0P84_RS11355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0P84_RS11360	COG0142	geranyltranstransferase activity
I0P84_RS11365	COG2828	Protein conserved in bacteria
I0P84_RS11370	COG1113	amino acid transport
I0P84_RS11390	COG0560	Phosphoserine phosphatase
I0P84_RS11400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I0P84_RS11415	COG0424	maF-like protein
I0P84_RS11420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I0P84_RS11425	COG1792	Involved in formation and maintenance of cell shape
I0P84_RS11430	COG1077	Cell shape determining protein MreB Mrl
I0P84_RS11435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I0P84_RS11445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I0P84_RS11465	COG0697	spore germination
I0P84_RS11475	COG3590	peptidase
I0P84_RS11480	COG3590	peptidase
I0P84_RS11490	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I0P84_RS11505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I0P84_RS11510	COG2223	nitrite transmembrane transporter activity
I0P84_RS11520	COG0500	methyltransferase
I0P84_RS11545	COG0783	Belongs to the Dps family
I0P84_RS11550	COG2826	transposase and inactivated derivatives, IS30 family
I0P84_RS11555	COG3706	GGDEF domain
I0P84_RS11565	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I0P84_RS11570	COG4149	molybdate abc transporter
I0P84_RS11575	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0P84_RS11580	COG0303	'Molybdopterin
I0P84_RS11585	COG0315	cyclic pyranopterin monophosphate synthase activity
I0P84_RS11585	COG0521	Mo-molybdopterin cofactor biosynthetic process
I0P84_RS11600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0P84_RS11610	COG0243	molybdopterin cofactor binding
I0P84_RS11615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0P84_RS11620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0P84_RS11625	COG2223	nitrite transmembrane transporter activity
I0P84_RS11645	COG1113	amino acid transport
I0P84_RS11650	COG1448	Aminotransferase
I0P84_RS11665	COG0625	glutathione transferase activity
I0P84_RS11680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0P84_RS11690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I0P84_RS11695	COG2814	Major facilitator Superfamily
I0P84_RS11700	COG1566	PFAM secretion protein HlyD family protein
I0P84_RS11705	COG2050	protein possibly involved in aromatic compounds catabolism
I0P84_RS11715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0P84_RS11720	COG1090	epimerase
I0P84_RS11740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I0P84_RS11795	COG0420	3'-5' exonuclease activity
I0P84_RS11825	COG0735	belongs to the Fur family
I0P84_RS11830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I0P84_RS11835	COG2914	Belongs to the UPF0125 (RnfH) family
I0P84_RS11850	COG0121	glutamine amidotransferase
I0P84_RS11865	COG0756	dUTP diphosphatase activity
I0P84_RS11875	COG2885	chlorophyll binding
I0P84_RS11880	COG0204	Acyl-transferase
I0P84_RS11890	COG0850	regulation of cytokinetic process
I0P84_RS11910	COG0531	amino acid
I0P84_RS11910	COG1674	ftsk spoiiie
I0P84_RS11915	COG0492	ferredoxin-NADP+ reductase activity
I0P84_RS11920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I0P84_RS11930	COG0456	acetyltransferase
I0P84_RS11955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I0P84_RS11970	COG1981	membrane
I0P84_RS11975	COG1113	amino acid transport
I0P84_RS11980	COG0251	oxidation-reduction process
I0P84_RS12000	COG1652	LysM domain
I0P84_RS12005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0P84_RS12010	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS12020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I0P84_RS12025	COG1399	metal-binding, possibly nucleic acid-binding protein
I0P84_RS12030	COG3101	peptidyl-lysine hydroxylation
I0P84_RS12035	COG0009	L-threonylcarbamoyladenylate synthase
I0P84_RS12050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I0P84_RS12055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I0P84_RS12080	COG0339	signal peptide processing
I0P84_RS12090	COG4166	transmembrane transport
I0P84_RS12100	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I0P84_RS12120	COG2193	ferroxidase activity
I0P84_RS12125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0P84_RS12130	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I0P84_RS12135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I0P84_RS12145	COG1196	nuclear chromosome segregation
I0P84_RS12155	COG0730	response to heat
I0P84_RS12170	COG3545	Serine hydrolase
I0P84_RS12180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I0P84_RS12195	COG2226	methyltransferase
I0P84_RS12205	COG3327	negative regulation of DNA-templated transcription, initiation
I0P84_RS12210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I0P84_RS12215	COG0183	Belongs to the thiolase family
I0P84_RS12220	COG1024	Enoyl-CoA hydratase
I0P84_RS12225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I0P84_RS12230	COG2151	metal-sulfur cluster biosynthetic enzyme
I0P84_RS12235	COG3396	Phenylacetate-CoA oxygenase
I0P84_RS12240	COG3460	Phenylacetate-CoA oxygenase
I0P84_RS12245	COG3396	Phenylacetate-CoA oxygenase
I0P84_RS12250	COG2030	dehydratase
I0P84_RS12250	COG1012	belongs to the aldehyde dehydrogenase family
I0P84_RS12255	COG2814	Major facilitator Superfamily
I0P84_RS12270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0P84_RS12280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I0P84_RS12300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I0P84_RS12315	COG1968	undecaprenyl-diphosphatase activity
I0P84_RS12320	COG1214	PFAM Peptidase M22, glycoprotease
I0P84_RS12330	COG0494	nUDIX hydrolase
I0P84_RS12380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I0P84_RS12385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I0P84_RS12465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I0P84_RS12470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I0P84_RS12485	COG0450	alkyl hydroperoxide reductase
I0P84_RS12500	COG0285	dihydrofolate synthase activity
I0P84_RS12550	COG2096	Adenosyltransferase
I0P84_RS12555	COG3293	Transposase
I0P84_RS12570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I0P84_RS12575	COG2315	Protein conserved in bacteria
I0P84_RS12585	COG1113	amino acid transport
I0P84_RS12595	COG0745	RESPONSE REGULATOR receiver
I0P84_RS12600	COG2205	protein histidine kinase activity
I0P84_RS12610	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS12615	COG1960	acyl-CoA dehydrogenase activity
I0P84_RS12655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I0P84_RS12710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I0P84_RS12715	COG2205	protein histidine kinase activity
I0P84_RS12730	COG1660	Displays ATPase and GTPase activities
I0P84_RS12745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I0P84_RS12750	COG0617	tRNA 3'-terminal CCA addition
I0P84_RS12755	COG1596	polysaccharide export
I0P84_RS12755	COG1555	photosystem II stabilization
I0P84_RS12760	COG3956	TIGRFAM MazG family protein
I0P84_RS12780	COG0675	Transposase, IS605 OrfB family
I0P84_RS12825	COG1426	Protein conserved in bacteria
I0P84_RS12845	COG2975	iron-sulfur cluster assembly
I0P84_RS12865	COG0028	Belongs to the TPP enzyme family
I0P84_RS12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0P84_RS12900	COG0577	efflux transmembrane transporter activity
I0P84_RS12900	COG1136	(ABC) transporter
I0P84_RS12905	COG1538	Outer membrane efflux protein
I0P84_RS12915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I0P84_RS12925	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I0P84_RS12930	COG1162	GTPase activity
I0P84_RS12960	COG0084	hydrolase, TatD family'
I0P84_RS12975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I0P84_RS12990	COG1674	ftsk spoiiie
I0P84_RS13025	COG2233	PERMEase
I0P84_RS13160	COG0793	Belongs to the peptidase S41A family
I0P84_RS13185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I0P84_RS13190	COG0857	belongs to the CobB CobQ family
I0P84_RS13190	COG0280	phosphate acetyltransferase
I0P84_RS13200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I0P84_RS13200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I0P84_RS13215	COG0740	serine-type endopeptidase activity
I0P84_RS13225	COG4774	siderophore transport
I0P84_RS13235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I0P84_RS13240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I0P84_RS13245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I0P84_RS13245	COG2813	Specifically methylates the guanine in position
I0P84_RS13295	COG3040	lipid binding
I0P84_RS13305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I0P84_RS13340	COG0788	formyltetrahydrofolate deformylase activity
I0P84_RS13365	COG4651	solute:proton antiporter activity
I0P84_RS13365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0P84_RS13380	COG0724	RNA recognition motif
I0P84_RS13385	COG0210	DNA helicase
I0P84_RS13390	COG1929	Belongs to the glycerate kinase type-1 family
I0P84_RS13430	COG2900	Belongs to the SlyX family
I0P84_RS13435	COG0488	(ABC) transporter
I0P84_RS13440	COG1560	Kdo2-lipid A biosynthetic process
I0P84_RS13505	COG0473	3-isopropylmalate dehydrogenase activity
I0P84_RS13520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I0P84_RS13570	COG0753	catalase activity
I0P84_RS13600	COG0519	Catalyzes the synthesis of GMP from XMP
I0P84_RS13610	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0P84_RS13615	COG3384	dioxygenase
I0P84_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS13635	COG4638	Rieske (2fe-2S)
I0P84_RS13640	COG0583	DNA-binding transcription factor activity
I0P84_RS13670	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I0P84_RS13675	COG3971	2-oxopent-4-enoate hydratase activity
I0P84_RS13680	COG0546	phosphoglycolate phosphatase activity
I0P84_RS13690	COG1530	ribonuclease E activity
I0P84_RS13695	COG0318	PFAM AMP-dependent synthetase and ligase
I0P84_RS13720	COG1983	PspC domain protein
I0P84_RS13730	COG0471	metal ion transport
I0P84_RS13735	COG0517	IMP dehydrogenase activity
I0P84_RS13735	COG0617	tRNA 3'-terminal CCA addition
I0P84_RS13735	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I0P84_RS13745	COG0752	glycyl-tRNA synthetase alpha subunit
I0P84_RS13750	COG0751	glycine-tRNA ligase activity
I0P84_RS13775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0P84_RS13790	COG2226	methyltransferase
I0P84_RS13800	COG0644	oxidoreductase
I0P84_RS13810	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I0P84_RS13820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0P84_RS13835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I0P84_RS13845	COG0644	oxidoreductase
I0P84_RS13845	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I0P84_RS13865	COG0425	Belongs to the sulfur carrier protein TusA family
I0P84_RS13870	COG4535	Mg2 and Co2 transporter CorC
I0P84_RS13895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I0P84_RS13905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I0P84_RS13925	COG0789	Transcriptional regulator
I0P84_RS13930	COG2841	Protein conserved in bacteria
I0P84_RS13940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I0P84_RS13945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I0P84_RS13950	COG1074	ATP-dependent DNA helicase activity
I0P84_RS13955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I0P84_RS13975	COG2226	methyltransferase
I0P84_RS13985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I0P84_RS14025	COG0427	acetyl-CoA hydrolase
I0P84_RS14030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I0P84_RS14065	COG0326	Molecular chaperone. Has ATPase activity
I0P84_RS14075	COG3047	cAMP biosynthetic process
I0P84_RS14080	COG2056	Na+-H+ antiporter family
I0P84_RS14100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I0P84_RS14105	COG0085	RNA polymerase activity
I0P84_RS14115	COG0222	ribosome binding
I0P84_RS14120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I0P84_RS14180	COG0546	phosphoglycolate phosphatase activity
I0P84_RS14210	COG0824	Thioesterase
I0P84_RS14230	COG0181	hydroxymethylbilane synthase activity
I0P84_RS14240	COG3275	phosphorelay sensor kinase activity
I0P84_RS14255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I0P84_RS14285	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0P84_RS14285	COG1024	Enoyl-CoA hydratase
I0P84_RS14290	COG0183	Belongs to the thiolase family
I0P84_RS14345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I0P84_RS14375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0P84_RS14410	COG3158	transport of potassium into the cell
I0P84_RS14465	COG0629	single-stranded DNA binding
I0P84_RS14470	COG2814	Major facilitator Superfamily
I0P84_RS14485	COG0352	thiamine-phosphate diphosphorylase activity
I0P84_RS14485	COG0351	phosphomethylpyrimidine kinase
I0P84_RS14485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0P84_RS14500	COG3706	GGDEF domain
I0P84_RS14510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0P84_RS14520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0P84_RS14525	COG3162	membrane
I0P84_RS14530	COG0784	Response regulator, receiver
I0P84_RS14530	COG2205	protein histidine kinase activity
I0P84_RS14530	COG2198	Histidine kinase
I0P84_RS14545	COG0431	NADPH-dependent FMN reductase
I0P84_RS14555	COG0307	riboflavin synthase, alpha
I0P84_RS14570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0P84_RS14580	COG0668	transmembrane transport
I0P84_RS14585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I0P84_RS14590	COG1519	Transferase
I0P84_RS14595	COG1902	pentaerythritol trinitrate reductase activity
I0P84_RS14620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I0P84_RS14645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0P84_RS14645	COG0426	domain, Protein
I0P84_RS14650	COG2119	membrane
I0P84_RS14680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I0P84_RS14690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I0P84_RS14700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I0P84_RS14715	COG0189	ligase activity
I0P84_RS14735	COG0708	Exodeoxyribonuclease III
I0P84_RS14755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I0P84_RS14760	COG3706	GGDEF domain
I0P84_RS14810	COG3150	esterase
I0P84_RS14820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I0P84_RS14825	COG2918	glutathione biosynthetic process
I0P84_RS14840	COG2733	membrane
I0P84_RS14880	COG0753	catalase activity
I0P84_RS14900	COG0560	Phosphoserine phosphatase
I0P84_RS14900	COG3830	Belongs to the UPF0237 family
I0P84_RS14915	COG0385	Bile acid
I0P84_RS14920	COG1335	isochorismatase
I0P84_RS14930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0P84_RS14940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I0P84_RS14945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I0P84_RS14950	COG3300	MHYT domain
I0P84_RS14950	COG5001	Diguanylate cyclase
I0P84_RS14955	COG2983	Belongs to the UPF0260 family
I0P84_RS14960	COG5487	UPF0391 membrane protein
I0P84_RS14970	COG3023	N-Acetylmuramoyl-L-alanine amidase
I0P84_RS14980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I0P84_RS14985	COG1309	transcriptional regulator
I0P84_RS14990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I0P84_RS14995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0P84_RS15000	COG0546	phosphoglycolate phosphatase activity
I0P84_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
I0P84_RS15035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I0P84_RS15035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I0P84_RS15040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0P84_RS15045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0P84_RS15050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0P84_RS15055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0P84_RS15060	COG1116	anion transmembrane transporter activity
I0P84_RS15065	COG1309	transcriptional regulator
I0P84_RS15075	COG0196	riboflavin kinase activity
I0P84_RS15080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I0P84_RS15090	COG1047	Peptidyl-prolyl cis-trans
I0P84_RS15105	COG2133	pyrroloquinoline quinone binding
I0P84_RS15110	COG2203	Gaf domain
I0P84_RS15110	COG3706	GGDEF domain
I0P84_RS15110	COG4251	negative regulation of phosphorylation
I0P84_RS15110	COG5001	Diguanylate cyclase
I0P84_RS15150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I0P84_RS15155	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I0P84_RS15160	COG2951	lytic endotransglycosylase activity
I0P84_RS15165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I0P84_RS15180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I0P84_RS15210	COG2814	Major facilitator Superfamily
I0P84_RS15215	COG0861	Integral membrane protein TerC family
I0P84_RS15220	COG0402	S-adenosylhomocysteine deaminase activity
I0P84_RS15235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I0P84_RS15260	COG0706	membrane insertase activity
I0P84_RS15265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I0P84_RS15270	COG0594	ribonuclease P activity
I0P84_RS15355	COG2755	lipolytic protein G-D-S-L family
I0P84_RS15355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I0P84_RS15365	COG1401	restriction endodeoxyribonuclease activity