locus-tag	class	description
CDG68_RS00125	COG1192	Involved in chromosome partitioning
CDG68_RS00185	COG1196	nuclear chromosome segregation
CDG68_RS00185	COG0741	lytic transglycosylase activity
CDG68_RS00185	COG0739	heme binding
CDG68_RS00200	COG1196	nuclear chromosome segregation
CDG68_RS00200	COG0741	lytic transglycosylase activity
CDG68_RS00200	COG0739	heme binding
CDG68_RS00210	COG3451	type IV secretory pathway VirB4
CDG68_RS00565	COG4772	TonB-dependent receptor
CDG68_RS00605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDG68_RS00610	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_RS00615	COG3657	addiction module killer protein
CDG68_RS00630	COG1309	transcriptional regulator
CDG68_RS00710	COG2337	Toxic component of a toxin-antitoxin (TA) module
CDG68_RS00715	COG2336	PFAM SpoVT AbrB
CDG68_RS00745	COG0488	(ABC) transporter
CDG68_RS00750	COG3173	Aminoglycoside phosphotransferase
CDG68_RS00905	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_RS00910	COG3657	addiction module killer protein
CDG68_RS00995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDG68_RS01155	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_RS01165	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_RS01205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDG68_RS01240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_RS01260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_RS01265	COG0625	glutathione transferase activity
CDG68_RS01305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDG68_RS01315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDG68_RS01335	COG2009	succinate dehydrogenase
CDG68_RS01520	COG1475	DNA binding
CDG68_RS01525	COG1192	Involved in chromosome partitioning
CDG68_RS01575	COG1061	Type III restriction enzyme res subunit
CDG68_RS01585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDG68_RS01590	COG1192	Involved in chromosome partitioning
CDG68_RS01600	COG1061	Type III restriction enzyme res subunit
CDG68_RS01955	COG4372	Transposase
CDG68_RS01975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CDG68_RS02000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDG68_RS02005	COG2076	Multidrug Resistance protein
CDG68_RS02070	COG2801	Transposase and inactivated derivatives
CDG68_RS02100	COG3173	Aminoglycoside phosphotransferase
CDG68_RS02105	COG0488	(ABC) transporter
CDG68_RS02170	COG1660	Displays ATPase and GTPase activities
CDG68_RS02190	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDG68_RS02305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDG68_RS02345	COG3421	Type III restriction
CDG68_RS02350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CDG68_RS02370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDG68_RS02440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_RS02445	COG0183	Belongs to the thiolase family
CDG68_RS02460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_RS02465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDG68_RS02475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_RS02540	COG1525	nuclease
CDG68_RS02595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDG68_RS02600	COG2076	Multidrug Resistance protein
CDG68_RS02645	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CDG68_RS02665	COG3328	transposase activity
CDG68_RS02675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDG68_RS02720	COG1192	Involved in chromosome partitioning
CDG68_RS02725	COG1475	DNA binding
CDG68_RS02755	COG2184	nucleotidyltransferase activity
CDG68_RS02925	COG0592	DNA-directed DNA polymerase activity
CDG68_RS02935	COG0187	DNA topoisomerase II activity
CDG68_RS02945	COG0488	(ABC) transporter
CDG68_RS02980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDG68_RS02990	COG1061	Type III restriction enzyme res subunit
CDG68_RS02995	COG1002	Type II restriction enzyme, methylase subunits
CDG68_RS03010	COG4584	PFAM Integrase catalytic
CDG68_RS03015	COG1484	DNA-dependent DNA replication
CDG68_RS03025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDG68_RS03030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CDG68_RS03035	COG0596	Alpha beta hydrolase
CDG68_RS03055	COG0657	acetylesterase activity
CDG68_RS03065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDG68_RS03200	COG1309	transcriptional regulator
CDG68_RS03205	COG1116	anion transmembrane transporter activity
CDG68_RS03210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDG68_RS03215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDG68_RS03220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_RS03225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_RS03230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDG68_RS03230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CDG68_RS03250	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS03255	COG0546	phosphoglycolate phosphatase activity
CDG68_RS03260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDG68_RS03275	COG1309	transcriptional regulator
CDG68_RS03285	COG1017	nitric oxide dioxygenase activity
CDG68_RS03285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_RS03320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDG68_RS03325	COG2814	Major facilitator Superfamily
CDG68_RS03330	COG1335	isochorismatase
CDG68_RS03335	COG0385	Bile acid
CDG68_RS03340	COG1683	Conserved Protein
CDG68_RS03350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CDG68_RS03385	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDG68_RS03415	COG1596	polysaccharide export
CDG68_RS03425	COG1216	Glycosyl transferase, family 2
CDG68_RS03425	COG1442	glycosyl transferase family 8
CDG68_RS03435	COG0438	transferase activity, transferring glycosyl groups
CDG68_RS03445	COG1216	Glycosyl transferase, family 2
CDG68_RS03450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CDG68_RS03455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CDG68_RS03470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDG68_RS03475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDG68_RS03500	COG1846	Transcriptional regulator
CDG68_RS03505	COG2309	aminopeptidase activity
CDG68_RS03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_RS03515	COG0596	Alpha beta hydrolase
CDG68_RS03520	COG3473	Maleate cis-trans isomerase
CDG68_RS03525	COG1335	isochorismatase
CDG68_RS03530	COG2271	Major facilitator Superfamily
CDG68_RS03545	COG0583	DNA-binding transcription factor activity
CDG68_RS03565	COG1012	belongs to the aldehyde dehydrogenase family
CDG68_RS03580	COG4628	conserved protein (DUF2132)
CDG68_RS03645	COG0271	Belongs to the BolA IbaG family
CDG68_RS03655	COG1192	Involved in chromosome partitioning
CDG68_RS03665	COG0586	Pfam SNARE associated Golgi protein
CDG68_RS03670	COG2259	Doxx family
CDG68_RS03680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDG68_RS03680	COG0519	Catalyzes the synthesis of GMP from XMP
CDG68_RS03715	COG1902	pentaerythritol trinitrate reductase activity
CDG68_RS03720	COG1519	Transferase
CDG68_RS03725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDG68_RS03730	COG0668	transmembrane transport
CDG68_RS03740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDG68_RS03760	COG0431	NADPH-dependent FMN reductase
CDG68_RS03770	COG2814	Major facilitator Superfamily
CDG68_RS03800	COG4452	Inner membrane protein CreD
CDG68_RS03805	COG2205	protein histidine kinase activity
CDG68_RS03815	COG0745	RESPONSE REGULATOR receiver
CDG68_RS03840	COG0281	malic enzyme
CDG68_RS03890	COG2837	iron assimilation
CDG68_RS03895	COG1280	lysine exporter protein (LysE YggA)
CDG68_RS03900	COG1280	lysine exporter protein (LysE YggA)
CDG68_RS03905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDG68_RS03910	COG1121	(ABC) transporter
CDG68_RS03920	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CDG68_RS03950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDG68_RS03960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CDG68_RS03995	COG0386	Belongs to the glutathione peroxidase family
CDG68_RS04010	COG2814	Major facilitator Superfamily
CDG68_RS04015	COG1309	transcriptional regulator
CDG68_RS04020	COG0697	spore germination
CDG68_RS04025	COG0009	L-threonylcarbamoyladenylate synthase
CDG68_RS04030	COG0758	DNA mediated transformation
CDG68_RS04035	COG1652	LysM domain
CDG68_RS04065	COG1309	transcriptional regulator
CDG68_RS04100	COG2133	pyrroloquinoline quinone binding
CDG68_RS04110	COG0655	NAD(P)H dehydrogenase (quinone) activity
CDG68_RS04135	COG0784	Response regulator, receiver
CDG68_RS04135	COG2205	protein histidine kinase activity
CDG68_RS04140	COG3162	membrane
CDG68_RS04145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDG68_RS04155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CDG68_RS04175	COG3706	GGDEF domain
CDG68_RS04215	COG1253	flavin adenine dinucleotide binding
CDG68_RS04230	COG2860	membrane
CDG68_RS04235	COG0477	Major facilitator Superfamily
CDG68_RS04260	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_RS04275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDG68_RS04305	COG0606	chelatase, subunit chli
CDG68_RS04315	COG0347	Belongs to the P(II) protein family
CDG68_RS04320	COG0004	ammonium transporteR
CDG68_RS04330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDG68_RS04330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDG68_RS04345	COG0586	Pfam SNARE associated Golgi protein
CDG68_RS04355	COG0772	Belongs to the SEDS family
CDG68_RS04360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDG68_RS04365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CDG68_RS04370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDG68_RS04380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDG68_RS04410	COG0488	(ABC) transporter
CDG68_RS04440	COG2329	Antibiotic biosynthesis monooxygenase
CDG68_RS04445	COG0697	spore germination
CDG68_RS04480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDG68_RS04525	COG0427	acetyl-CoA hydrolase
CDG68_RS04550	COG4221	oxidoreductase activity
CDG68_RS04630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDG68_RS04655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDG68_RS04660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDG68_RS04665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDG68_RS04670	COG2226	methyltransferase
CDG68_RS04720	COG0067	glutamate synthase
CDG68_RS04720	COG0069	glutamate synthase activity
CDG68_RS04720	COG0070	glutamate synthase
CDG68_RS04725	COG0493	'glutamate synthase
CDG68_RS04735	COG0307	riboflavin synthase, alpha
CDG68_RS04740	COG1320	monovalent cation:proton antiporter activity
CDG68_RS04745	COG2212	antiporter activity
CDG68_RS04750	COG1863	multisubunit Na H antiporter MnhE subunit
CDG68_RS04755	COG0651	ATP synthesis coupled electron transport
CDG68_RS04760	COG1006	Multisubunit Na H antiporter MnhC subunit
CDG68_RS04765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDG68_RS04765	COG2111	Na H antiporter
CDG68_RS04795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDG68_RS04820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDG68_RS04850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CDG68_RS04855	COG1074	ATP-dependent DNA helicase activity
CDG68_RS04860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_RS04865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CDG68_RS04885	COG0598	Magnesium transport protein CorA
CDG68_RS04895	COG0789	Transcriptional regulator
CDG68_RS04900	COG0484	heat shock protein binding
CDG68_RS04910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CDG68_RS04920	COG2226	methyltransferase
CDG68_RS04965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDG68_RS05030	COG0517	IMP dehydrogenase activity
CDG68_RS05035	COG1983	PspC domain protein
CDG68_RS05065	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_RS05070	COG1530	ribonuclease E activity
CDG68_RS05075	COG0564	pseudouridine synthase activity
CDG68_RS05080	COG0546	phosphoglycolate phosphatase activity
CDG68_RS05085	COG3971	2-oxopent-4-enoate hydratase activity
CDG68_RS05090	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDG68_RS05105	COG1473	amidohydrolase
CDG68_RS05125	COG2161	toxin-antitoxin pair type II binding
CDG68_RS05135	COG0583	DNA-binding transcription factor activity
CDG68_RS05140	COG4638	Rieske (2fe-2S)
CDG68_RS05160	COG3384	dioxygenase
CDG68_RS05165	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDG68_RS05170	COG0456	acetyltransferase
CDG68_RS05200	COG3011	Protein conserved in bacteria
CDG68_RS05205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CDG68_RS05220	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS05235	COG1522	sequence-specific DNA binding
CDG68_RS05240	COG1280	lysine exporter protein (LysE YggA)
CDG68_RS05255	COG0494	nUDIX hydrolase
CDG68_RS05270	COG0583	DNA-binding transcription factor activity
CDG68_RS05285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDG68_RS05300	COG0473	3-isopropylmalate dehydrogenase activity
CDG68_RS05315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDG68_RS05330	COG0101	tRNA pseudouridine synthase activity
CDG68_RS05335	COG0252	asparaginase activity
CDG68_RS05380	COG1560	Kdo2-lipid A biosynthetic process
CDG68_RS05395	COG0488	(ABC) transporter
CDG68_RS05400	COG2900	Belongs to the SlyX family
CDG68_RS05440	COG1929	Belongs to the glycerate kinase type-1 family
CDG68_RS05450	COG0210	DNA helicase
CDG68_RS05470	COG4651	solute:proton antiporter activity
CDG68_RS05470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDG68_RS05495	COG0788	formyltetrahydrofolate deformylase activity
CDG68_RS05535	COG1607	acyl-coa hydrolase
CDG68_RS05570	COG2350	Protein conserved in bacteria
CDG68_RS05580	COG0613	PHP domain protein
CDG68_RS05590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDG68_RS05595	COG1702	phosphate starvation-inducible protein PhoH
CDG68_RS05600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDG68_RS05605	COG0739	heme binding
CDG68_RS05605	COG0741	lytic transglycosylase activity
CDG68_RS05605	COG1196	nuclear chromosome segregation
CDG68_RS05640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CDG68_RS05645	COG1183	phosphatidylcholine synthase activity
CDG68_RS05710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CDG68_RS05715	COG3878	Protein conserved in bacteria
CDG68_RS05755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDG68_RS05770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDG68_RS05775	COG1063	alcohol dehydrogenase
CDG68_RS05785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_RS05785	COG2813	Specifically methylates the guanine in position
CDG68_RS05790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_RS05795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDG68_RS05805	COG3128	pkhd-type hydroxylase
CDG68_RS05810	COG4774	siderophore transport
CDG68_RS05815	COG4774	siderophore transport
CDG68_RS05820	COG4771	TonB-dependent receptor
CDG68_RS05830	COG0740	serine-type endopeptidase activity
CDG68_RS05880	COG0857	belongs to the CobB CobQ family
CDG68_RS05880	COG0280	phosphate acetyltransferase
CDG68_RS05885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CDG68_RS05920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDG68_RS05930	COG0726	polysaccharide deacetylase
CDG68_RS05935	COG0084	hydrolase, TatD family'
CDG68_RS05940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CDG68_RS05950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDG68_RS05985	COG2814	Major facilitator Superfamily
CDG68_RS05995	COG0789	Transcriptional regulator
CDG68_RS06040	COG1862	Preprotein translocase
CDG68_RS06075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CDG68_RS06090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CDG68_RS06115	COG0438	transferase activity, transferring glycosyl groups
CDG68_RS06140	COG2990	Protein conserved in bacteria
CDG68_RS06155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDG68_RS06185	COG3223	Belongs to the PsiE family
CDG68_RS06200	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS06205	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS06210	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_RS06245	COG0625	glutathione transferase activity
CDG68_RS06255	COG1238	metal cluster binding
CDG68_RS06275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDG68_RS06310	COG0072	phenylalanine-tRNA ligase activity
CDG68_RS06315	COG0776	regulation of translation
CDG68_RS06335	COG0248	Ppx GppA phosphatase
CDG68_RS06345	COG0037	tRNA processing
CDG68_RS06355	COG0762	integral membrane protein
CDG68_RS06375	COG0183	Belongs to the thiolase family
CDG68_RS06390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CDG68_RS06390	COG2885	chlorophyll binding
CDG68_RS06400	COG1690	Belongs to the RtcB family
CDG68_RS06405	COG0833	amino acid
CDG68_RS06415	COG2233	PERMEase
CDG68_RS06420	COG1217	gtp-binding protein TYPA
CDG68_RS06430	COG1970	mechanosensitive ion channel activity
CDG68_RS06445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDG68_RS06455	COG3659	wide pore channel activity
CDG68_RS06460	COG4772	TonB-dependent receptor
CDG68_RS06465	COG1902	pentaerythritol trinitrate reductase activity
CDG68_RS06480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDG68_RS06490	COG0009	L-threonylcarbamoyladenylate synthase
CDG68_RS06495	COG3101	peptidyl-lysine hydroxylation
CDG68_RS06500	COG1399	metal-binding, possibly nucleic acid-binding protein
CDG68_RS06520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDG68_RS06525	COG1652	LysM domain
CDG68_RS06530	COG0450	alkyl hydroperoxide reductase
CDG68_RS06545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDG68_RS06550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDG68_RS06580	COG2199	diguanylate cyclase activity
CDG68_RS06625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDG68_RS06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDG68_RS06690	COG0489	protein tyrosine kinase activity
CDG68_RS06740	COG0644	oxidoreductase
CDG68_RS06745	COG0442	prolyl-tRNA aminoacylation
CDG68_RS06770	COG0840	transmembrane signaling receptor activity
CDG68_RS06775	COG0784	Response regulator, receiver
CDG68_RS06775	COG0643	Histidine kinase
CDG68_RS06775	COG2198	Histidine kinase
CDG68_RS06800	COG2832	Protein of unknown function (DUF454)
CDG68_RS06855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CDG68_RS06865	COG1289	transmembrane transporter activity
CDG68_RS06870	COG2814	Major facilitator Superfamily
CDG68_RS06880	COG1090	epimerase
CDG68_RS06885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDG68_RS06895	COG2050	protein possibly involved in aromatic compounds catabolism
CDG68_RS06900	COG1566	PFAM secretion protein HlyD family protein
CDG68_RS06905	COG2814	Major facilitator Superfamily
CDG68_RS06950	COG0306	phosphate transporter
CDG68_RS06975	COG0175	sulfate reduction
CDG68_RS07040	COG2851	Citrate transporter
CDG68_RS07045	COG1253	flavin adenine dinucleotide binding
CDG68_RS07065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDG68_RS07070	COG2894	cell division
CDG68_RS07075	COG0850	regulation of cytokinetic process
CDG68_RS07085	COG0204	Acyl-transferase
CDG68_RS07090	COG2885	chlorophyll binding
CDG68_RS07095	COG0210	DNA helicase
CDG68_RS07100	COG0756	dUTP diphosphatase activity
CDG68_RS07105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDG68_RS07110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDG68_RS07120	COG0121	glutamine amidotransferase
CDG68_RS07135	COG2914	Belongs to the UPF0125 (RnfH) family
CDG68_RS07140	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDG68_RS07145	COG0735	belongs to the Fur family
CDG68_RS07190	COG0420	3'-5' exonuclease activity
CDG68_RS07220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDG68_RS07240	COG0786	glutamate:sodium symporter activity
CDG68_RS07245	COG2059	Chromate
CDG68_RS07250	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDG68_RS07260	COG1607	acyl-coa hydrolase
CDG68_RS07270	COG1309	transcriptional regulator
CDG68_RS07275	COG2814	Major facilitator Superfamily
CDG68_RS07280	COG0583	DNA-binding transcription factor activity
CDG68_RS07295	COG2188	Transcriptional regulator
CDG68_RS07315	COG0523	cobalamin synthesis protein
CDG68_RS07320	COG4681	YaeQ
CDG68_RS07330	COG1649	PFAM Uncharacterised BCR, COG1649
CDG68_RS07330	COG0726	polysaccharide deacetylase
CDG68_RS07335	COG1215	transferase activity, transferring glycosyl groups
CDG68_RS07375	COG1024	Enoyl-CoA hydratase
CDG68_RS07390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDG68_RS07410	COG4771	TonB-dependent receptor
CDG68_RS07440	COG1113	amino acid transport
CDG68_RS07445	COG2828	Protein conserved in bacteria
CDG68_RS07455	COG0142	geranyltranstransferase activity
CDG68_RS07460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDG68_RS07475	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDG68_RS07510	COG2194	sulfuric ester hydrolase activity
CDG68_RS07515	COG0745	RESPONSE REGULATOR receiver
CDG68_RS07520	COG0642	Histidine kinase
CDG68_RS07530	COG0004	ammonium transporteR
CDG68_RS07565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDG68_RS07575	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDG68_RS07580	COG1077	Cell shape determining protein MreB Mrl
CDG68_RS07585	COG1792	Involved in formation and maintenance of cell shape
CDG68_RS07590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CDG68_RS07595	COG0424	maF-like protein
CDG68_RS07600	COG1530	ribonuclease E activity
CDG68_RS07605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDG68_RS07615	COG0560	Phosphoserine phosphatase
CDG68_RS07625	COG4181	ATPase activity
CDG68_RS07630	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CDG68_RS07635	COG0586	Pfam SNARE associated Golgi protein
CDG68_RS07650	COG1309	transcriptional regulator
CDG68_RS07660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDG68_RS07685	COG0193	aminoacyl-tRNA hydrolase activity
CDG68_RS07695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDG68_RS07735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CDG68_RS07745	COG0358	DNA primase activity
CDG68_RS07755	COG0564	pseudouridine synthase activity
CDG68_RS07775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDG68_RS07785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDG68_RS07855	COG0477	Major facilitator Superfamily
CDG68_RS07875	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CDG68_RS07895	COG0459	protein refolding
CDG68_RS07900	COG2169	Transcriptional regulator
CDG68_RS07905	COG2223	nitrite transmembrane transporter activity
CDG68_RS07920	COG1840	ABC-type Fe3 transport system, periplasmic component
CDG68_RS07925	COG3842	ATPase activity
CDG68_RS07940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CDG68_RS07945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDG68_RS07970	COG0584	glycerophosphoryl diester phosphodiesterase
CDG68_RS07975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDG68_RS07980	COG2239	Acts as a magnesium transporter
CDG68_RS08020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDG68_RS08025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDG68_RS08030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDG68_RS08045	COG1115	amino acid carrier protein
CDG68_RS08050	COG1113	amino acid transport
CDG68_RS08060	COG0019	diaminopimelate decarboxylase activity
CDG68_RS08065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDG68_RS08085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CDG68_RS08110	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CDG68_RS08125	COG0833	amino acid
CDG68_RS08140	COG0833	amino acid
CDG68_RS08150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDG68_RS08155	COG0418	dihydroorotase activity
CDG68_RS08175	COG0501	Belongs to the peptidase M48B family
CDG68_RS08180	COG0741	lytic transglycosylase activity
CDG68_RS08185	COG0037	tRNA processing
CDG68_RS08195	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CDG68_RS08205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDG68_RS08300	COG0583	DNA-binding transcription factor activity
CDG68_RS08320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_RS08330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDG68_RS08335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CDG68_RS08340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDG68_RS08340	COG4451	ribulose bisphosphate carboxylase, small
CDG68_RS08345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDG68_RS08350	COG1469	GTP cyclohydrolase I activity
CDG68_RS08355	COG0735	belongs to the Fur family
CDG68_RS08390	COG0523	cobalamin synthesis protein
CDG68_RS08420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDG68_RS08460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CDG68_RS08465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDG68_RS08485	COG2375	cellular response to nickel ion
CDG68_RS08485	COG1132	(ABC) transporter
CDG68_RS08495	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDG68_RS08500	COG4605	iron ion homeostasis
CDG68_RS08505	COG4604	ABC transporter, ATP-binding protein
CDG68_RS08510	COG4607	ABC-type enterochelin transport system periplasmic component
CDG68_RS08515	COG4774	siderophore transport
CDG68_RS08535	COG1595	DNA-templated transcription, initiation
CDG68_RS08540	COG3712	iron ion homeostasis
CDG68_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS08585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_RS08600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_RS08600	COG0543	2 iron, 2 sulfur cluster binding
CDG68_RS08605	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CDG68_RS08610	COG4638	Rieske (2fe-2S)
CDG68_RS08690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_RS08695	COG0183	Belongs to the thiolase family
CDG68_RS08700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDG68_RS08705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CDG68_RS08710	COG4829	muconolactone delta-isomerase
CDG68_RS08715	COG4948	Mandelate Racemase Muconate Lactonizing
CDG68_RS08720	COG0583	DNA-binding transcription factor activity
CDG68_RS08725	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CDG68_RS08730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDG68_RS08735	COG3485	protocatechuate 3,4-dioxygenase
CDG68_RS08740	COG3135	benzoate transporter
CDG68_RS08745	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS08750	COG0543	2 iron, 2 sulfur cluster binding
CDG68_RS08750	COG0633	Ferredoxin
CDG68_RS08755	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CDG68_RS08760	COG4638	Rieske (2fe-2S)
CDG68_RS08765	COG0583	DNA-binding transcription factor activity
CDG68_RS08770	COG2814	Major facilitator Superfamily
CDG68_RS08775	COG2203	Gaf domain
CDG68_RS08775	COG5001	Diguanylate cyclase
CDG68_RS08775	COG3706	GGDEF domain
CDG68_RS08775	COG4251	negative regulation of phosphorylation
CDG68_RS08785	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CDG68_RS08820	COG0280	phosphate acetyltransferase
CDG68_RS08820	COG0281	malic enzyme
CDG68_RS08830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDG68_RS08840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CDG68_RS08885	COG2050	protein possibly involved in aromatic compounds catabolism
CDG68_RS08890	COG1187	pseudouridine synthase activity
CDG68_RS08935	COG0583	DNA-binding transcription factor activity
CDG68_RS08940	COG0697	spore germination
CDG68_RS08950	COG2186	Transcriptional regulator
CDG68_RS08960	COG0277	FAD linked oxidase domain protein
CDG68_RS08975	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDG68_RS08975	COG1902	pentaerythritol trinitrate reductase activity
CDG68_RS08995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS09020	COG1116	anion transmembrane transporter activity
CDG68_RS09020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_RS09025	COG0745	RESPONSE REGULATOR receiver
CDG68_RS09030	COG2223	nitrite transmembrane transporter activity
CDG68_RS09035	COG2146	nitrite reductase [NAD(P)H] activity
CDG68_RS09035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_RS09045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_RS09050	COG0243	molybdopterin cofactor binding
CDG68_RS09060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDG68_RS09075	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDG68_RS09075	COG0315	cyclic pyranopterin monophosphate synthase activity
CDG68_RS09080	COG0303	'Molybdopterin
CDG68_RS09085	COG0725	ABC transporter, periplasmic molybdate-binding protein
CDG68_RS09090	COG4149	molybdate abc transporter
CDG68_RS09105	COG3712	iron ion homeostasis
CDG68_RS09130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_RS09140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDG68_RS09150	COG0582	viral genome integration into host DNA
CDG68_RS09175	COG0006	proline dipeptidase activity
CDG68_RS09185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_RS09190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_RS09200	COG0625	glutathione transferase activity
CDG68_RS09240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDG68_RS09245	COG0741	lytic transglycosylase activity
CDG68_RS09245	COG1388	LysM domain
CDG68_RS09250	COG4166	transmembrane transport
CDG68_RS09255	COG4174	ABC transporter (Permease)
CDG68_RS09260	COG4239	(ABC) transporter, permease
CDG68_RS09265	COG4172	Belongs to the ABC transporter superfamily
CDG68_RS09275	COG2223	nitrite transmembrane transporter activity
CDG68_RS09280	COG3708	Transcriptional regulator
CDG68_RS09280	COG2207	Transcriptional regulator
CDG68_RS09290	COG0583	DNA-binding transcription factor activity
CDG68_RS09315	COG0024	Methionine aminopeptidase
CDG68_RS09320	COG0052	Belongs to the universal ribosomal protein uS2 family
CDG68_RS09375	COG2951	lytic endotransglycosylase activity
CDG68_RS09380	COG0772	Belongs to the SEDS family
CDG68_RS09395	COG0842	Transport permease protein
CDG68_RS09400	COG1131	(ABC) transporter
CDG68_RS09425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDG68_RS09430	COG1301	dicarboxylic acid transport
CDG68_RS09435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CDG68_RS09445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDG68_RS09480	COG2318	DinB family
CDG68_RS09485	COG2070	2-Nitropropane dioxygenase
CDG68_RS09560	COG1643	Atp-dependent helicase
CDG68_RS09595	COG2831	hemolysin activation secretion protein
CDG68_RS09605	COG2072	flavoprotein involved in K transport
CDG68_RS09610	COG4221	oxidoreductase activity
CDG68_RS09615	COG1280	lysine exporter protein (LysE YggA)
CDG68_RS09625	COG4591	ABC-type transport system involved in lipoprotein release permease component
CDG68_RS09630	COG1136	(ABC) transporter
CDG68_RS09635	COG0658	competence protein
CDG68_RS09635	COG2333	competence protein COMEC
CDG68_RS09660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDG68_RS09665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDG68_RS09670	COG0628	permease
CDG68_RS09715	COG3634	alkyl hydroperoxide reductase activity
CDG68_RS09730	COG0583	DNA-binding transcription factor activity
CDG68_RS09735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDG68_RS09740	COG0826	peptidase U32
CDG68_RS09745	COG0640	Transcriptional regulator
CDG68_RS09750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDG68_RS09755	COG0798	PFAM Bile acid sodium symporter
CDG68_RS09775	COG1720	tRNA m6t6A37 methyltransferase activity
CDG68_RS09960	COG2011	ABC-type metal ion transport system permease component
CDG68_RS09965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDG68_RS09970	COG1464	Belongs to the NlpA lipoprotein family
CDG68_RS10000	COG0138	bifunctional purine biosynthesis protein purh
CDG68_RS10005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CDG68_RS10040	COG2814	Major facilitator Superfamily
CDG68_RS10050	COG2308	Evidence 4 Homologs of previously reported genes of
CDG68_RS10060	COG1305	Transglutaminase-like
CDG68_RS10070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDG68_RS10085	COG0305	Participates in initiation and elongation during chromosome replication
CDG68_RS10095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDG68_RS10100	COG0360	Binds together with S18 to 16S ribosomal RNA
CDG68_RS10120	COG0109	protoheme IX farnesyltransferase activity
CDG68_RS10125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CDG68_RS10130	COG1845	cytochrome c oxidase, subunit III
CDG68_RS10135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDG68_RS10140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDG68_RS10165	COG4682	membrane
CDG68_RS10170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDG68_RS10185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDG68_RS10190	COG2890	protein-(glutamine-N5) methyltransferase activity
CDG68_RS10195	COG3781	membrane
CDG68_RS10200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDG68_RS10205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_RS10225	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS10230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDG68_RS10235	COG1741	Belongs to the pirin family
CDG68_RS10240	COG4771	TonB-dependent receptor
CDG68_RS10250	COG0204	Acyl-transferase
CDG68_RS10265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CDG68_RS10275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CDG68_RS10315	COG0477	Major facilitator Superfamily
CDG68_RS10320	COG0729	surface antigen
CDG68_RS10335	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_RS10355	COG4783	chaperone-mediated protein folding
CDG68_RS10365	COG1610	YqeY-like protein
CDG68_RS10395	COG0436	Aminotransferase
CDG68_RS10400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_RS10405	COG0386	Belongs to the glutathione peroxidase family
CDG68_RS10420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDG68_RS10440	COG0668	transmembrane transport
CDG68_RS10465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDG68_RS10465	COG0519	Catalyzes the synthesis of GMP from XMP
CDG68_RS10470	COG1309	transcriptional regulator
CDG68_RS10490	COG0583	DNA-binding transcription factor activity
CDG68_RS10500	COG3284	Transcriptional regulator
CDG68_RS10510	COG4221	oxidoreductase activity
CDG68_RS10515	COG1454	alcohol dehydrogenase
CDG68_RS10520	COG0183	Belongs to the thiolase family
CDG68_RS10550	COG0824	Thioesterase
CDG68_RS10560	COG1454	alcohol dehydrogenase
CDG68_RS10565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDG68_RS10655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CDG68_RS10675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDG68_RS10685	COG0133	tryptophan synthase activity
CDG68_RS10700	COG0517	IMP dehydrogenase activity
CDG68_RS10700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CDG68_RS10735	COG0612	Peptidase, M16
CDG68_RS10740	COG0552	protein localization to endoplasmic reticulum
CDG68_RS10755	COG2707	UPF0756 membrane protein
CDG68_RS10780	COG0802	atpase or kinase
CDG68_RS10785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CDG68_RS10795	COG1923	regulation of RNA biosynthetic process
CDG68_RS10800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDG68_RS10810	COG3178	'Phosphotransferase
CDG68_RS10815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDG68_RS10825	COG1192	Involved in chromosome partitioning
CDG68_RS10830	COG1475	DNA binding
CDG68_RS10835	COG0811	peptide transport
CDG68_RS10845	COG1132	(ABC) transporter
CDG68_RS10850	COG1663	tetraacyldisaccharide 4'-kinase activity
CDG68_RS10870	COG0084	hydrolase, TatD family'
CDG68_RS10905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CDG68_RS10915	COG0590	tRNA wobble adenosine to inosine editing
CDG68_RS10960	COG0284	orotidine-5'-phosphate decarboxylase activity
CDG68_RS10970	COG2431	L-lysine efflux transmembrane transporter activity
CDG68_RS10985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CDG68_RS10990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CDG68_RS10995	COG0569	domain protein
CDG68_RS11010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDG68_RS11015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CDG68_RS11055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDG68_RS11060	COG0542	response to heat
CDG68_RS11135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDG68_RS11150	COG0308	aminopeptidase N
CDG68_RS11155	COG0582	viral genome integration into host DNA
CDG68_RS11325	COG4383	Mu-like prophage protein gp29
CDG68_RS11555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDG68_RS11555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDG68_RS11555	COG0506	proline dehydrogenase activity
CDG68_RS11570	COG1027	Aspartate ammonia-lyase
CDG68_RS11580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CDG68_RS11605	COG0477	Major facilitator Superfamily
CDG68_RS11620	COG1902	pentaerythritol trinitrate reductase activity
CDG68_RS11620	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDG68_RS11645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CDG68_RS11655	COG4115	mRNA cleavage
CDG68_RS11660	COG2161	toxin-antitoxin pair type II binding
CDG68_RS11665	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CDG68_RS11675	COG0772	Belongs to the SEDS family
CDG68_RS11680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDG68_RS11700	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CDG68_RS11705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_RS11725	COG0583	DNA-binding transcription factor activity
CDG68_RS11730	COG0667	Aldo Keto reductase
CDG68_RS11760	COG1309	transcriptional regulator
CDG68_RS11770	COG2937	Belongs to the GPAT DAPAT family
CDG68_RS11775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDG68_RS11785	COG0424	maF-like protein
CDG68_RS11815	COG0583	DNA-binding transcription factor activity
CDG68_RS11820	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS11830	COG3196	Protein conserved in bacteria
CDG68_RS11870	COG0702	epimerase
CDG68_RS11875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDG68_RS11900	COG4589	Belongs to the CDS family
CDG68_RS11915	COG0671	phosphoesterase, PA-phosphatase related
CDG68_RS11915	COG2453	phosphatase
CDG68_RS11920	COG2267	carboxylic ester hydrolase activity
CDG68_RS11925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CDG68_RS11965	COG2223	nitrite transmembrane transporter activity
CDG68_RS11990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDG68_RS12010	COG3122	Protein conserved in bacteria
CDG68_RS12015	COG3619	membrane
CDG68_RS12030	COG0640	Transcriptional regulator
CDG68_RS12065	COG5001	Diguanylate cyclase
CDG68_RS12065	COG3300	MHYT domain
CDG68_RS12070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDG68_RS12085	COG2030	dehydratase
CDG68_RS12100	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS12145	COG1546	Belongs to the CinA family
CDG68_RS12145	COG1058	Belongs to the CinA family
CDG68_RS12160	COG0589	response to stress
CDG68_RS12185	COG1944	ATP diphosphatase activity
CDG68_RS12205	COG0789	Transcriptional regulator
CDG68_RS12220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_RS12225	COG0730	response to heat
CDG68_RS12235	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CDG68_RS12240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CDG68_RS12250	COG2205	protein histidine kinase activity
CDG68_RS12265	COG0583	DNA-binding transcription factor activity
CDG68_RS12275	COG1346	cytolysis
CDG68_RS12280	COG2814	Major facilitator Superfamily
CDG68_RS12510	COG1484	DNA-dependent DNA replication
CDG68_RS12560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CDG68_RS12600	COG5377	YqaJ viral recombinase family
CDG68_RS12610	COG0210	DNA helicase
CDG68_RS12645	COG0596	Alpha beta hydrolase
CDG68_RS12655	COG4771	TonB-dependent receptor
CDG68_RS12665	COG1448	Aminotransferase
CDG68_RS12670	COG0488	(ABC) transporter
CDG68_RS12680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CDG68_RS12685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDG68_RS12700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDG68_RS12705	COG0697	spore germination
CDG68_RS12770	COG1294	oxidase, subunit
CDG68_RS12775	COG1271	oxidase subunit
CDG68_RS12810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDG68_RS12865	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDG68_RS12870	COG2207	Transcriptional regulator
CDG68_RS12875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDG68_RS12880	COG0776	regulation of translation
CDG68_RS12895	COG1959	2 iron, 2 sulfur cluster binding
CDG68_RS12905	COG0822	iron-sulfur transferase activity
CDG68_RS12910	COG0316	Belongs to the HesB IscA family
CDG68_RS12940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CDG68_RS12955	COG2850	peptidyl-arginine hydroxylation
CDG68_RS12965	COG0069	glutamate synthase activity
CDG68_RS12980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDG68_RS12990	COG0372	Belongs to the citrate synthase family
CDG68_RS13025	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS13030	COG0583	DNA-binding transcription factor activity
CDG68_RS13040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDG68_RS13045	COG0583	DNA-binding transcription factor activity
CDG68_RS13070	COG0511	ligase activity, forming carbon-carbon bonds
CDG68_RS13075	COG0439	Biotin carboxylase
CDG68_RS13085	COG2199	diguanylate cyclase activity
CDG68_RS13105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CDG68_RS13115	COG1477	protein flavinylation
CDG68_RS13125	COG0730	response to heat
CDG68_RS13130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDG68_RS13160	COG1011	Hydrolase
CDG68_RS13165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CDG68_RS13170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDG68_RS13175	COG4221	oxidoreductase activity
CDG68_RS13180	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_RS13185	COG2137	regulation of response to DNA damage stimulus
CDG68_RS13200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_RS13210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_RS13220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDG68_RS13235	COG0575	Belongs to the CDS family
CDG68_RS13240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDG68_RS13260	COG3852	Histidine kinase
CDG68_RS13300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_RS13305	COG1304	FMN binding
CDG68_RS13310	COG1132	(ABC) transporter
CDG68_RS13315	COG1846	Transcriptional regulator
CDG68_RS13320	COG2814	Major facilitator Superfamily
CDG68_RS13325	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CDG68_RS13355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDG68_RS13365	COG1585	Membrane protein implicated in regulation of membrane protease activity
CDG68_RS13380	COG1294	oxidase, subunit
CDG68_RS13385	COG4890	Cyd operon protein YbgT
CDG68_RS13390	COG3790	cyd operon protein YbgE
CDG68_RS13445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_RS13460	COG0583	DNA-binding transcription factor activity
CDG68_RS13465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDG68_RS13475	COG3135	benzoate transporter
CDG68_RS13480	COG0024	Methionine aminopeptidase
CDG68_RS13485	COG1114	Component of the transport system for branched-chain amino acids
CDG68_RS13505	COG1253	flavin adenine dinucleotide binding
CDG68_RS13525	COG3220	belongs to the UPF0276 family
CDG68_RS13535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CDG68_RS13545	COG0583	DNA-binding transcription factor activity
CDG68_RS13550	COG0786	glutamate:sodium symporter activity
CDG68_RS13560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDG68_RS13565	COG1113	amino acid transport
CDG68_RS13590	COG2807	transmembrane transport
CDG68_RS13595	COG0590	tRNA wobble adenosine to inosine editing
CDG68_RS13655	COG1464	Belongs to the NlpA lipoprotein family
CDG68_RS13660	COG1464	Belongs to the NlpA lipoprotein family
CDG68_RS13665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDG68_RS13670	COG2011	ABC-type metal ion transport system permease component
CDG68_RS13680	COG0012	GTP binding
CDG68_RS13685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDG68_RS13695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDG68_RS13710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CDG68_RS13730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CDG68_RS13755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_RS13775	COG1280	lysine exporter protein (LysE YggA)
CDG68_RS13805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CDG68_RS13805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDG68_RS13810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDG68_RS13860	COG0778	Nitroreductase
CDG68_RS13870	COG0513	Belongs to the DEAD box helicase family
CDG68_RS13875	COG1278	Cold shock
CDG68_RS13890	COG2363	Small membrane protein
CDG68_RS13910	COG0625	glutathione transferase activity
CDG68_RS13925	COG3851	Histidine kinase
CDG68_RS13940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDG68_RS13950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDG68_RS13980	COG0540	Belongs to the ATCase OTCase family
CDG68_RS14015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CDG68_RS14020	COG0542	response to heat
CDG68_RS14025	COG1045	serine acetyltransferase
CDG68_RS14035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDG68_RS14040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDG68_RS14050	COG1765	OsmC-like protein
CDG68_RS14060	COG0667	Aldo Keto reductase
CDG68_RS14075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDG68_RS14110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDG68_RS14120	COG0183	Belongs to the thiolase family
CDG68_RS14140	COG0527	aspartate kinase activity
CDG68_RS14150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDG68_RS14160	COG3038	cytochrome b561
CDG68_RS14170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CDG68_RS14175	COG2252	PERMEase
CDG68_RS14195	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CDG68_RS14200	COG0583	DNA-binding transcription factor activity
CDG68_RS14245	COG0714	Associated with various cellular activities
CDG68_RS14255	COG2879	small protein
CDG68_RS14260	COG1966	Carbon starvation protein
CDG68_RS14265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CDG68_RS14270	COG1509	lysine 2,3-aminomutase activity
CDG68_RS14300	COG2211	Major facilitator Superfamily
CDG68_RS14305	COG1067	ATP-dependent peptidase activity
CDG68_RS14310	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDG68_RS14315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDG68_RS14330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDG68_RS14345	COG1686	Belongs to the peptidase S11 family
CDG68_RS14350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDG68_RS14355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDG68_RS14365	COG0573	inorganic phosphate transmembrane transporter activity
CDG68_RS14380	COG4122	O-methyltransferase activity
CDG68_RS14405	COG1137	ATPase activity
CDG68_RS14410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CDG68_RS14420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CDG68_RS14425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CDG68_RS14425	COG0517	IMP dehydrogenase activity
CDG68_RS14475	COG0427	acetyl-CoA hydrolase
CDG68_RS14480	COG0183	Belongs to the thiolase family
CDG68_RS14485	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS14500	COG0583	DNA-binding transcription factor activity
CDG68_RS14545	COG1671	Belongs to the UPF0178 family
CDG68_RS14555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CDG68_RS14580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_RS14595	COG1301	dicarboxylic acid transport
CDG68_RS14605	COG0047	phosphoribosylformylglycinamidine synthase activity
CDG68_RS14605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDG68_RS14630	COG0632	four-way junction helicase activity
CDG68_RS14645	COG0824	Thioesterase
CDG68_RS14670	COG0823	Involved in the tonB-independent uptake of proteins
CDG68_RS14690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDG68_RS14715	COG0174	glutamine synthetase
CDG68_RS14740	COG0512	Glutamine amidotransferase of anthranilate synthase
CDG68_RS14745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDG68_RS14765	COG0302	gtp cyclohydrolase
CDG68_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS14795	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS14815	COG3739	integral membrane protein
CDG68_RS14830	COG1741	Belongs to the pirin family
CDG68_RS14900	COG0352	thiamine-phosphate diphosphorylase activity
CDG68_RS14910	COG3022	response to hydroperoxide
CDG68_RS14920	COG4650	regulator
CDG68_RS14935	COG1234	tRNA 3'-trailer cleavage
CDG68_RS14945	COG1690	Belongs to the RtcB family
CDG68_RS14970	COG0430	RNA-3'-phosphate cyclase activity
CDG68_RS14985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDG68_RS14995	COG0693	protein deglycase activity
CDG68_RS15000	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS15005	COG0616	signal peptide processing
CDG68_RS15030	COG0482	sulfurtransferase activity
CDG68_RS15035	COG2915	High frequency lysogenization protein hflD homolog
CDG68_RS15055	COG1733	regulation of RNA biosynthetic process
CDG68_RS15060	COG0702	epimerase
CDG68_RS15090	COG0556	nucleotide-excision repair
CDG68_RS15110	COG0436	Aminotransferase
CDG68_RS15165	COG3299	homolog of phage Mu protein gp47
CDG68_RS15220	COG4397	Mu-like prophage major head subunit gpT
CDG68_RS15240	COG2369	cell adhesion
CDG68_RS15245	COG4383	Mu-like prophage protein gp29
CDG68_RS15265	COG4373	Mu-like prophage FluMu protein gp28
CDG68_RS15300	COG1396	sequence-specific DNA binding
CDG68_RS15340	COG0776	regulation of translation
CDG68_RS15370	COG4382	Mu-like prophage protein Gp16
CDG68_RS15425	COG2871	sodium ion transport
CDG68_RS15440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDG68_RS15450	COG0076	glutamate decarboxylase activity
CDG68_RS15455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CDG68_RS15465	COG0671	phosphoesterase, PA-phosphatase related
CDG68_RS15470	COG4772	TonB-dependent receptor
CDG68_RS15495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_RS15515	COG1022	Amp-dependent synthetase and ligase
CDG68_RS15520	COG2197	response regulator
CDG68_RS15555	COG4993	Dehydrogenase
CDG68_RS15585	COG0612	Peptidase, M16
CDG68_RS15590	COG0384	phenazine biosynthesis protein PhzF
CDG68_RS15600	COG1823	symporter activity
CDG68_RS15605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_RS15620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDG68_RS15635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDG68_RS15665	COG3139	Protein of unknown function (DUF1315)
CDG68_RS15670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDG68_RS15675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDG68_RS15685	COG0494	nUDIX hydrolase
CDG68_RS15695	COG0642	Histidine kinase
CDG68_RS15710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CDG68_RS15740	COG1203	CRISPR-associated helicase, Cas3
CDG68_RS15745	COG1518	maintenance of DNA repeat elements
CDG68_RS15755	COG3327	negative regulation of DNA-templated transcription, initiation
CDG68_RS15760	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CDG68_RS15765	COG0183	Belongs to the thiolase family
CDG68_RS15770	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDG68_RS15775	COG1024	Enoyl-CoA hydratase
CDG68_RS15780	COG1024	Enoyl-CoA hydratase
CDG68_RS15785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_RS15790	COG2151	metal-sulfur cluster biosynthetic enzyme
CDG68_RS15795	COG3396	Phenylacetate-CoA oxygenase
CDG68_RS15800	COG3460	Phenylacetate-CoA oxygenase
CDG68_RS15805	COG3396	Phenylacetate-CoA oxygenase
CDG68_RS15810	COG1012	belongs to the aldehyde dehydrogenase family
CDG68_RS15810	COG2030	dehydratase
CDG68_RS15820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDG68_RS15825	COG0477	Major facilitator Superfamily
CDG68_RS15840	COG1116	anion transmembrane transporter activity
CDG68_RS15845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDG68_RS15855	COG0864	Transcriptional regulator
CDG68_RS15870	COG0439	Biotin carboxylase
CDG68_RS15885	COG1063	alcohol dehydrogenase
CDG68_RS15890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_RS15895	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDG68_RS15900	COG0022	dehydrogenase e1 component
CDG68_RS15905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CDG68_RS15910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDG68_RS15925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_RS15930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDG68_RS15945	COG1686	Belongs to the peptidase S11 family
CDG68_RS15950	COG1252	NADH dehydrogenase
CDG68_RS15955	COG1047	Peptidyl-prolyl cis-trans
CDG68_RS15960	COG0415	Belongs to the DNA photolyase family
CDG68_RS15980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDG68_RS15995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDG68_RS16000	COG0571	ribonuclease III activity
CDG68_RS16030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDG68_RS16060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDG68_RS16065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CDG68_RS16070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDG68_RS16080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CDG68_RS16085	COG4208	sulfate ABC transporter
CDG68_RS16090	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDG68_RS16095	COG0583	DNA-binding transcription factor activity
CDG68_RS16115	COG0602	queuosine metabolic process
CDG68_RS16120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CDG68_RS16135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDG68_RS16145	COG0583	DNA-binding transcription factor activity
CDG68_RS16160	COG1024	Enoyl-CoA hydratase
CDG68_RS16165	COG0778	Nitroreductase
CDG68_RS16175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDG68_RS16175	COG3323	Protein of unknown function (DUF1653)
CDG68_RS16205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDG68_RS16225	COG1280	lysine exporter protein (LysE YggA)
CDG68_RS16260	COG2234	aminopeptidase activity
CDG68_RS16265	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CDG68_RS16270	COG3384	dioxygenase
CDG68_RS16295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDG68_RS16300	COG2878	Part of a membrane complex involved in electron transport
CDG68_RS16305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDG68_RS16335	COG0768	penicillin binding
CDG68_RS16340	COG0742	ribosomal rna small subunit methyltransferase
CDG68_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS16360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CDG68_RS16370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_RS16385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDG68_RS16390	COG1053	succinate dehydrogenase
CDG68_RS16395	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CDG68_RS16400	COG2009	succinate dehydrogenase
CDG68_RS16425	COG2072	flavoprotein involved in K transport
CDG68_RS16430	COG0300	oxidoreductase activity
CDG68_RS16455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDG68_RS16455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CDG68_RS16480	COG2304	oxidoreductase activity
CDG68_RS16490	COG2304	oxidoreductase activity
CDG68_RS16495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDG68_RS16500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDG68_RS16505	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CDG68_RS16525	COG0505	Belongs to the CarA family
CDG68_RS16530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDG68_RS16545	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CDG68_RS16565	COG1024	Enoyl-CoA hydratase
CDG68_RS16595	COG2321	neutral zinc metallopeptidase
CDG68_RS16600	COG2354	Protein conserved in bacteria
CDG68_RS16625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CDG68_RS16630	COG1773	rubredoxin
CDG68_RS16635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_RS16640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_RS16645	COG0583	DNA-binding transcription factor activity
CDG68_RS16680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDG68_RS16690	COG0321	lipoyl(octanoyl) transferase activity
CDG68_RS16705	COG0531	amino acid
CDG68_RS16715	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS16735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CDG68_RS16740	COG1648	precorrin-2 dehydrogenase activity
CDG68_RS16740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDG68_RS16745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDG68_RS16755	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CDG68_RS16760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CDG68_RS16775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDG68_RS16790	COG0671	phosphoesterase, PA-phosphatase related
CDG68_RS16795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_RS16805	COG1538	Outer membrane efflux protein
CDG68_RS16810	COG0393	Putative heavy-metal-binding
CDG68_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS16845	COG0525	valine-tRNA ligase activity
CDG68_RS16905	COG3590	peptidase
CDG68_RS16935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDG68_RS16945	COG0582	viral genome integration into host DNA
CDG68_RS16985	COG3210	domain, Protein
CDG68_RS16990	COG2831	hemolysin activation secretion protein
CDG68_RS17145	COG0625	glutathione transferase activity
CDG68_RS17195	COG4372	Transposase
CDG68_RS17205	COG0582	viral genome integration into host DNA
CDG68_RS17225	COG0242	peptide deformylase activity
CDG68_RS17235	COG0477	Major facilitator Superfamily
CDG68_RS17285	COG1585	Membrane protein implicated in regulation of membrane protease activity
CDG68_RS17290	COG2268	Band 7 protein
CDG68_RS17315	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CDG68_RS17315	COG1674	ftsk spoiiie
CDG68_RS17320	COG0492	ferredoxin-NADP+ reductase activity
CDG68_RS17325	COG0500	methyltransferase
CDG68_RS17330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CDG68_RS17340	COG0456	acetyltransferase
CDG68_RS17365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDG68_RS17385	COG1981	membrane
CDG68_RS17400	COG1113	amino acid transport
CDG68_RS17405	COG0251	oxidation-reduction process
CDG68_RS17435	COG0351	phosphomethylpyrimidine kinase
CDG68_RS17435	COG0352	thiamine-phosphate diphosphorylase activity
CDG68_RS17435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CDG68_RS17475	COG2132	Multicopper oxidase
CDG68_RS17485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDG68_RS17500	COG4269	membrane
CDG68_RS17505	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CDG68_RS17520	COG1968	undecaprenyl-diphosphatase activity
CDG68_RS17525	COG1214	PFAM Peptidase M22, glycoprotease
CDG68_RS17530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDG68_RS17535	COG0494	nUDIX hydrolase
CDG68_RS17575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDG68_RS17585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDG68_RS17590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDG68_RS17615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDG68_RS17620	COG0765	amino acid transport
CDG68_RS17625	COG0765	amino acid transport
CDG68_RS17630	COG1126	abc transporter atp-binding protein
CDG68_RS17650	COG4716	Myosin-crossreactive antigen
CDG68_RS17685	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CDG68_RS17690	COG3210	domain, Protein
CDG68_RS17700	COG2081	HI0933 family
CDG68_RS17705	COG0668	transmembrane transport
CDG68_RS17725	COG0583	DNA-binding transcription factor activity
CDG68_RS17755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDG68_RS17760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDG68_RS17765	COG0713	ATP synthesis coupled electron transport
CDG68_RS17775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDG68_RS17780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDG68_RS17790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CDG68_RS17810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDG68_RS17820	COG2205	protein histidine kinase activity
CDG68_RS17825	COG0745	RESPONSE REGULATOR receiver
CDG68_RS17840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDG68_RS17850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CDG68_RS17855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CDG68_RS17875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDG68_RS17880	COG0601	transmembrane transport
CDG68_RS17890	COG4166	transmembrane transport
CDG68_RS17895	COG4166	transmembrane transport
CDG68_RS17925	COG2824	Alkylphosphonate utilization operon protein PhnA
CDG68_RS17955	COG1408	metallophosphoesterase
CDG68_RS17960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDG68_RS17970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDG68_RS17980	COG1346	cytolysis
CDG68_RS18005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDG68_RS18010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDG68_RS18020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDG68_RS18025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDG68_RS18030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDG68_RS18040	COG0625	glutathione transferase activity
CDG68_RS18045	COG2969	positive regulation of protein catabolic process
CDG68_RS18120	COG0354	folic acid binding
CDG68_RS18155	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CDG68_RS18180	COG0285	dihydrofolate synthase activity
CDG68_RS18185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDG68_RS18230	COG0183	Belongs to the thiolase family
CDG68_RS18240	COG2207	Transcriptional regulator
CDG68_RS18245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDG68_RS18260	COG0494	nUDIX hydrolase
CDG68_RS18275	COG3422	double-strand break repair
CDG68_RS18295	COG4106	trans-aconitate 2-methyltransferase activity
CDG68_RS18310	COG2267	carboxylic ester hydrolase activity
CDG68_RS18315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDG68_RS18320	COG2193	ferroxidase activity
CDG68_RS18355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDG68_RS18365	COG1196	nuclear chromosome segregation
CDG68_RS18385	COG0730	response to heat
CDG68_RS18405	COG3545	Serine hydrolase
CDG68_RS18410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CDG68_RS18475	COG2153	protein acetylation
CDG68_RS18485	COG1272	protein, Hemolysin III
CDG68_RS18490	COG0477	Major facilitator Superfamily
CDG68_RS18495	COG0564	pseudouridine synthase activity
CDG68_RS18505	COG1024	Enoyl-CoA hydratase
CDG68_RS18510	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS18515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDG68_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_RS18530	COG1309	transcriptional regulator
CDG68_RS18550	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS18555	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS18560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDG68_RS18610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDG68_RS18620	COG1764	response to oxidative stress
CDG68_RS18685	COG3384	dioxygenase
CDG68_RS18700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_RS18725	COG4206	TonB-dependent receptor
CDG68_RS18755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDG68_RS18785	COG2315	Protein conserved in bacteria
CDG68_RS18790	COG0745	RESPONSE REGULATOR receiver
CDG68_RS18795	COG2205	protein histidine kinase activity
CDG68_RS18805	COG3028	Belongs to the UPF0307 family
CDG68_RS18810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDG68_RS18815	COG1660	Displays ATPase and GTPase activities
CDG68_RS18820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDG68_RS18830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CDG68_RS18835	COG0617	tRNA 3'-terminal CCA addition
CDG68_RS18840	COG1596	polysaccharide export
CDG68_RS18840	COG1555	photosystem II stabilization
CDG68_RS18845	COG3956	TIGRFAM MazG family protein
CDG68_RS18860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDG68_RS18880	COG5002	protein histidine kinase activity
CDG68_RS18880	COG2205	protein histidine kinase activity
CDG68_RS18880	COG0784	Response regulator, receiver
CDG68_RS18885	COG1024	Enoyl-CoA hydratase
CDG68_RS18890	COG2084	Dehydrogenase
CDG68_RS18895	COG3622	Belongs to the hyi family
CDG68_RS18905	COG0004	ammonium transporteR
CDG68_RS18920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDG68_RS18940	COG1426	Protein conserved in bacteria
CDG68_RS19005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDG68_RS19010	COG0440	acetolactate synthase activity
CDG68_RS19015	COG0028	Belongs to the TPP enzyme family
CDG68_RS19040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_RS19045	COG0577	efflux transmembrane transporter activity
CDG68_RS19045	COG1136	(ABC) transporter
CDG68_RS19050	COG1538	Outer membrane efflux protein
CDG68_RS19115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CDG68_RS19120	COG1162	GTPase activity
CDG68_RS19165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CDG68_RS19170	COG2003	Belongs to the UPF0758 family
CDG68_RS19175	COG3781	membrane
CDG68_RS19205	COG1946	Acyl-CoA thioesterase
CDG68_RS19225	COG1295	ribonuclease BN
CDG68_RS19255	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDG68_RS19280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDG68_RS19285	COG1126	abc transporter atp-binding protein
CDG68_RS19290	COG0765	amino acid transport
CDG68_RS19295	COG0765	amino acid transport
CDG68_RS19325	COG0557	exoribonuclease II activity
CDG68_RS19345	COG0339	signal peptide processing
CDG68_RS19350	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CDG68_RS19360	COG0697	spore germination
CDG68_RS19390	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CDG68_RS19395	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS19415	COG2072	flavoprotein involved in K transport
CDG68_RS19420	COG0203	ribosomal protein L17
CDG68_RS19425	COG0202	RNA polymerase activity
CDG68_RS19465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDG68_RS19475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDG68_RS19480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDG68_RS19485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDG68_RS19500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDG68_RS19520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDG68_RS19530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDG68_RS19545	COG0088	Forms part of the polypeptide exit tunnel
CDG68_RS19555	COG0051	transcription antitermination factor activity, RNA binding
CDG68_RS19565	COG0626	cystathionine gamma-synthase activity
CDG68_RS19570	COG0433	COG0433 Predicted ATPase
CDG68_RS19575	COG1017	nitric oxide dioxygenase activity
CDG68_RS19575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_RS19580	COG1959	2 iron, 2 sulfur cluster binding
CDG68_RS19595	COG1301	dicarboxylic acid transport
CDG68_RS19600	COG1946	Acyl-CoA thioesterase
CDG68_RS19605	COG2937	Belongs to the GPAT DAPAT family
CDG68_RS19640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDG68_RS19645	COG1040	competence protein
CDG68_RS19650	COG0494	nUDIX hydrolase
CDG68_RS19660	COG0598	Magnesium transport protein CorA
CDG68_RS19670	COG2854	intermembrane phospholipid transfer
CDG68_RS19675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDG68_RS19680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDG68_RS19685	COG1127	ABC transporter
CDG68_RS19690	COG0513	Belongs to the DEAD box helicase family
CDG68_RS19705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDG68_RS19710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDG68_RS19715	COG0408	coproporphyrinogen oxidase activity
CDG68_RS19735	COG1960	acyl-CoA dehydrogenase activity
CDG68_RS19745	COG2814	Major facilitator Superfamily
CDG68_RS19750	COG1733	regulation of RNA biosynthetic process
CDG68_RS19755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDG68_RS19765	COG0534	Mate efflux family protein
CDG68_RS19775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDG68_RS19780	COG0254	rRNA binding
CDG68_RS19785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CDG68_RS19800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_RS19810	COG0493	'glutamate synthase
CDG68_RS19810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDG68_RS19820	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CDG68_RS19835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDG68_RS19850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDG68_RS19860	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CDG68_RS19860	COG0644	oxidoreductase
CDG68_RS19880	COG0425	Belongs to the sulfur carrier protein TusA family
CDG68_RS19885	COG4535	Mg2 and Co2 transporter CorC
CDG68_RS19890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDG68_RS19915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CDG68_RS19940	COG0628	permease
CDG68_RS19945	COG2032	superoxide dismutase activity
CDG68_RS19960	COG1289	transmembrane transporter activity
CDG68_RS19965	COG2814	Major facilitator Superfamily
CDG68_RS20000	COG0277	FAD linked oxidase domain protein
CDG68_RS20005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDG68_RS20010	COG5006	permease, DMT superfamily
CDG68_RS20015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDG68_RS20055	COG5380	lipid catabolic process
CDG68_RS20060	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CDG68_RS20070	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CDG68_RS20075	COG0335	large ribosomal subunit rRNA binding
CDG68_RS20085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDG68_RS20090	COG0228	four-way junction DNA binding
CDG68_RS20175	COG4969	Belongs to the N-Me-Phe pilin family
CDG68_RS20180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDG68_RS20185	COG0194	GDP metabolic process
CDG68_RS20190	COG1758	RNA polymerase activity
CDG68_RS20195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDG68_RS20215	COG3307	-O-antigen
CDG68_RS20225	COG3307	-O-antigen
CDG68_RS20240	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CDG68_RS20245	COG1704	LemA family
CDG68_RS20255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDG68_RS20265	COG0195	Participates in both transcription termination and antitermination
CDG68_RS20270	COG0779	Required for maturation of 30S ribosomal subunits
CDG68_RS20320	COG0237	dephospho-CoA kinase activity
CDG68_RS20330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDG68_RS20345	COG0497	DNA recombination
CDG68_RS20370	COG1678	Uncharacterized ACR, COG1678
CDG68_RS20375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CDG68_RS20385	COG1566	PFAM secretion protein HlyD family protein
CDG68_RS20395	COG1289	transmembrane transporter activity
CDG68_RS20405	COG2249	NAD(P)H dehydrogenase (quinone) activity
CDG68_RS20415	COG1132	(ABC) transporter
CDG68_RS20435	COG4974	Belongs to the 'phage' integrase family
CDG68_RS20440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDG68_RS20450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CDG68_RS20455	COG1686	Belongs to the peptidase S11 family
CDG68_RS20460	COG2197	response regulator
CDG68_RS20465	COG5002	protein histidine kinase activity
CDG68_RS20475	COG0793	Belongs to the peptidase S41A family
CDG68_RS20480	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CDG68_RS20485	COG0795	lipopolysaccharide-transporting ATPase activity
CDG68_RS20490	COG0795	lipopolysaccharide-transporting ATPase activity
CDG68_RS20520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CDG68_RS20550	COG1024	Enoyl-CoA hydratase
CDG68_RS20550	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDG68_RS20555	COG0183	Belongs to the thiolase family
CDG68_RS20575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CDG68_RS20595	COG0326	Molecular chaperone. Has ATPase activity
CDG68_RS20615	COG2056	Na+-H+ antiporter family
CDG68_RS20645	COG0085	RNA polymerase activity
CDG68_RS20655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDG68_RS20660	COG0081	regulation of translation
CDG68_RS20675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDG68_RS20765	COG0181	hydroxymethylbilane synthase activity
CDG68_RS20775	COG3275	phosphorelay sensor kinase activity
CDG68_RS20800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CDG68_RS20815	COG3158	transport of potassium into the cell
CDG68_RS20850	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CDG68_RS20910	COG0629	single-stranded DNA binding
CDG68_RS20930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDG68_RS20975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CDG68_RS21050	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_RS21080	COG1324	tolerance protein
CDG68_RS21085	COG0673	inositol 2-dehydrogenase activity
CDG68_RS21105	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_RS21185	COG2814	Major facilitator Superfamily
CDG68_RS21195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CDG68_RS21195	COG0352	thiamine-phosphate diphosphorylase activity
CDG68_RS21195	COG0351	phosphomethylpyrimidine kinase
CDG68_RS21235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDG68_RS21240	COG0697	spore germination
CDG68_RS21285	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CDG68_RS21320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDG68_RS21345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_RS21345	COG0426	domain, Protein
CDG68_RS21350	COG2119	membrane
CDG68_RS21375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDG68_RS21390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CDG68_RS21400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDG68_RS21410	COG0189	ligase activity
CDG68_RS21435	COG0708	Exodeoxyribonuclease III
CDG68_RS21440	COG1393	Belongs to the ArsC family
CDG68_RS21460	COG3706	GGDEF domain
CDG68_RS21490	COG1247	-acetyltransferase
CDG68_RS21505	COG3150	esterase
CDG68_RS21525	COG2918	glutathione biosynthetic process
CDG68_RS21540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CDG68_RS21550	COG2733	membrane
CDG68_RS21570	COG0436	Aminotransferase
CDG68_RS21575	COG0534	Mate efflux family protein
CDG68_RS21645	COG0560	Phosphoserine phosphatase
CDG68_RS21645	COG3830	Belongs to the UPF0237 family
CDG68_RS21660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDG68_RS21670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CDG68_RS21675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CDG68_RS21685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CDG68_RS21765	COG0514	ATP-dependent DNA helicase (RecQ)
CDG68_RS21790	COG2207	Transcriptional regulator
CDG68_RS21795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDG68_RS21810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDG68_RS21815	COG2819	hydrolase of the alpha beta superfamily
CDG68_RS21820	COG2983	Belongs to the UPF0260 family
CDG68_RS21825	COG5487	UPF0391 membrane protein
CDG68_RS21830	COG5487	UPF0391 membrane protein
CDG68_RS21845	COG1194	a g-specific adenine glycosylase
CDG68_RS21850	COG0739	heme binding
CDG68_RS21860	COG2818	Glycosylase
CDG68_RS21865	COG1064	alcohol dehydrogenase
CDG68_RS21870	COG0156	8-amino-7-oxononanoate synthase activity
CDG68_RS21880	COG0583	DNA-binding transcription factor activity
CDG68_RS21885	COG0656	L-ascorbic acid biosynthetic process
CDG68_RS21890	COG2814	Major facilitator Superfamily
CDG68_RS21930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_RS21940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDG68_RS21945	COG2233	PERMEase
CDG68_RS21955	COG1228	amidohydrolase
CDG68_RS21965	COG0196	riboflavin kinase activity
CDG68_RS21970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDG68_RS21975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDG68_RS21980	COG1047	Peptidyl-prolyl cis-trans
CDG68_RS21990	COG3077	Addiction module antitoxin, RelB DinJ family
CDG68_RS21995	COG0583	DNA-binding transcription factor activity
CDG68_RS22005	COG0174	glutamine synthetase
CDG68_RS22045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDG68_RS22060	COG0733	neurotransmitter:sodium symporter activity
CDG68_RS22065	COG3738	Protein conserved in bacteria
CDG68_RS22070	COG1012	belongs to the aldehyde dehydrogenase family
CDG68_RS22085	COG2814	Major facilitator Superfamily
CDG68_RS22120	COG0737	Belongs to the 5'-nucleotidase family
CDG68_RS22130	COG2175	clavaminate synthase activity
CDG68_RS22135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDG68_RS22140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CDG68_RS22145	COG4521	taurine ABC transporter
CDG68_RS22165	COG0443	Heat shock 70 kDa protein
CDG68_RS22170	COG0789	Transcriptional regulator
CDG68_RS22205	COG2951	lytic endotransglycosylase activity
CDG68_RS22215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CDG68_RS22240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDG68_RS22260	COG2388	GCN5-related N-acetyl-transferase
CDG68_RS22265	COG2388	GCN5-related N-acetyl-transferase
CDG68_RS22275	COG0861	Integral membrane protein TerC family
CDG68_RS22290	COG0754	glutathionylspermidine amidase activity
CDG68_RS22305	COG0402	S-adenosylhomocysteine deaminase activity
CDG68_RS22320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDG68_RS22325	COG1230	cation diffusion facilitator family transporter
CDG68_RS22355	COG0706	membrane insertase activity
CDG68_RS22360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane