locus-tag	class	description
UA74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UA74_RS00010	COG0592	DNA-directed DNA polymerase activity
UA74_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
UA74_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UA74_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
UA74_RS00030	COG0187	DNA topoisomerase II activity
UA74_RS00070	COG2311	Membrane
UA74_RS00100	COG3764	Sortase (surface protein transpeptidase)
UA74_RS00125	COG0515	serine threonine protein kinase
UA74_RS00130	COG0768	penicillin binding
UA74_RS00145	COG1716	ATPase activity
UA74_RS00150	COG1716	ATPase activity
UA74_RS00165	COG0018	arginyl-trna synthetase
UA74_RS00185	COG1309	transcriptional regulator
UA74_RS00215	COG1276	copper resistance
UA74_RS00215	COG2372	response to copper ion
UA74_RS00235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UA74_RS00250	COG1174	glycine betaine transport
UA74_RS00275	COG0667	Aldo Keto reductase
UA74_RS00305	COG0438	transferase activity, transferring glycosyl groups
UA74_RS00320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UA74_RS00325	COG4115	mRNA cleavage
UA74_RS00330	COG2161	toxin-antitoxin pair type II binding
UA74_RS00350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UA74_RS00370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UA74_RS00400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UA74_RS00410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UA74_RS00420	COG3279	Response regulator of the LytR AlgR family
UA74_RS00430	COG3275	phosphorelay sensor kinase activity
UA74_RS00450	COG0653	protein targeting
UA74_RS00485	COG1528	Iron-storage protein
UA74_RS00490	COG2235	arginine
UA74_RS00535	COG1271	oxidase subunit
UA74_RS00545	COG1294	oxidase, subunit
UA74_RS00550	COG4988	ABC transporter
UA74_RS00570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UA74_RS00600	COG0754	glutathionylspermidine amidase activity
UA74_RS00605	COG3766	membrane
UA74_RS00625	COG0561	phosphatase activity
UA74_RS00630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UA74_RS00660	COG0579	oxidoreductase
UA74_RS00675	COG1216	Glycosyl transferase, family 2
UA74_RS00685	COG1216	Glycosyl transferase, family 2
UA74_RS00715	COG0604	alcohol dehydrogenase
UA74_RS00720	COG2234	aminopeptidase activity
UA74_RS00780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UA74_RS00790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UA74_RS00820	COG0183	Belongs to the thiolase family
UA74_RS00830	COG0287	Prephenate dehydrogenase
UA74_RS00840	COG0590	tRNA wobble adenosine to inosine editing
UA74_RS00865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UA74_RS00890	COG1349	DNA-binding transcription factor activity
UA74_RS00895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UA74_RS00910	COG0601	transmembrane transport
UA74_RS00915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS00920	COG0444	Belongs to the ABC transporter superfamily
UA74_RS00930	COG0667	Aldo Keto reductase
UA74_RS00945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UA74_RS00950	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS00955	COG1914	H( )-stimulated, divalent metal cation uptake system
UA74_RS00975	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS00980	COG1129	ABC transporter
UA74_RS01005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UA74_RS01010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UA74_RS01020	COG0747	negative chemotaxis
UA74_RS01025	COG0601	transmembrane transport
UA74_RS01030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS01035	COG0444	Belongs to the ABC transporter superfamily
UA74_RS01040	COG4608	Belongs to the ABC transporter superfamily
UA74_RS01100	COG1764	response to oxidative stress
UA74_RS01110	COG3469	chitinase activity
UA74_RS01125	COG3591	Belongs to the peptidase S1B family
UA74_RS01140	COG1408	metallophosphoesterase
UA74_RS01155	COG4499	WXG100 protein secretion system (Wss), protein YukC
UA74_RS01155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UA74_RS01195	COG0673	inositol 2-dehydrogenase activity
UA74_RS01215	COG0592	DNA-directed DNA polymerase activity
UA74_RS01255	COG0596	Alpha beta hydrolase
UA74_RS01265	COG0730	response to heat
UA74_RS01290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UA74_RS01295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UA74_RS01305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
UA74_RS01310	COG1737	Transcriptional regulator
UA74_RS01335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UA74_RS01340	COG3876	Protein conserved in bacteria
UA74_RS01345	COG1472	Belongs to the glycosyl hydrolase 3 family
UA74_RS01395	COG1111	helicase
UA74_RS01395	COG1205	dead DEAH box helicase
UA74_RS01400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
UA74_RS01410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UA74_RS01410	COG1754	DNA topoisomerase type I activity
UA74_RS01420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UA74_RS01425	COG0470	DNA polymerase III
UA74_RS01435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UA74_RS01445	COG0587	DNA-directed DNA polymerase activity
UA74_RS01450	COG3973	AAA domain
UA74_RS01470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
UA74_RS01480	COG2027	D-alanyl-D-alanine carboxypeptidase
UA74_RS01505	COG0037	tRNA processing
UA74_RS01515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UA74_RS01520	COG0302	gtp cyclohydrolase
UA74_RS01525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UA74_RS01565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UA74_RS01570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UA74_RS01575	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UA74_RS01580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UA74_RS01605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
UA74_RS01620	COG1194	a g-specific adenine glycosylase
UA74_RS01630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UA74_RS01640	COG1329	Transcriptional regulator
UA74_RS01645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UA74_RS01660	COG0215	cysteine-tRNA ligase activity
UA74_RS01710	COG0483	inositol monophosphate 1-phosphatase activity
UA74_RS01720	COG2226	methyltransferase
UA74_RS01730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UA74_RS01735	COG3842	ATPase activity
UA74_RS01740	COG0803	Belongs to the bacterial solute-binding protein 9 family
UA74_RS01745	COG3842	ATPase activity
UA74_RS01750	COG3833	ABC-type maltose transport systems, permease component
UA74_RS01770	COG1609	Transcriptional regulator
UA74_RS01785	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
UA74_RS01800	COG0667	Aldo Keto reductase
UA74_RS01805	COG0456	acetyltransferase
UA74_RS01810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UA74_RS01815	COG1917	Cupin 2, conserved barrel domain protein
UA74_RS01820	COG5285	phytanoyl-CoA dioxygenase
UA74_RS01830	COG3629	intracellular signal transduction
UA74_RS01830	COG3903	Transcriptional regulator
UA74_RS01850	COG2186	Transcriptional regulator
UA74_RS01870	COG0242	peptide deformylase activity
UA74_RS01875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UA74_RS01880	COG0351	phosphomethylpyrimidine kinase
UA74_RS01895	COG2022	thiamine diphosphate biosynthetic process
UA74_RS01905	COG2022	thiamine diphosphate biosynthetic process
UA74_RS01905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UA74_RS01910	COG0352	thiamine-phosphate diphosphorylase activity
UA74_RS01920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UA74_RS01950	COG2188	Transcriptional regulator
UA74_RS01960	COG1175	transmembrane transport
UA74_RS01965	COG0395	ABC-type sugar transport system, permease component
UA74_RS01970	COG1472	Belongs to the glycosyl hydrolase 3 family
UA74_RS01975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UA74_RS01990	COG2197	response regulator
UA74_RS02000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UA74_RS02005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UA74_RS02085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UA74_RS02130	COG0788	formyltetrahydrofolate deformylase activity
UA74_RS02135	COG1309	transcriptional regulator
UA74_RS02155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UA74_RS02190	COG0477	Major facilitator Superfamily
UA74_RS02200	COG0438	transferase activity, transferring glycosyl groups
UA74_RS02210	COG0588	phosphoglycerate mutase activity
UA74_RS02215	COG5002	protein histidine kinase activity
UA74_RS02235	COG0506	proline dehydrogenase activity
UA74_RS02240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UA74_RS02275	COG1960	acyl-CoA dehydrogenase activity
UA74_RS02295	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
UA74_RS02300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
UA74_RS02315	COG0113	porphobilinogen synthase activity
UA74_RS02355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UA74_RS02360	COG0406	alpha-ribazole phosphatase activity
UA74_RS02370	COG0515	serine threonine protein kinase
UA74_RS02370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UA74_RS02375	COG0785	Cytochrome C biogenesis protein
UA74_RS02385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UA74_RS02435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UA74_RS02475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
UA74_RS02495	COG3396	Phenylacetate-CoA oxygenase
UA74_RS02500	COG3460	Phenylacetate-CoA oxygenase
UA74_RS02505	COG3396	Phenylacetate-CoA oxygenase
UA74_RS02510	COG2151	metal-sulfur cluster biosynthetic enzyme
UA74_RS02515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UA74_RS02530	COG2226	methyltransferase
UA74_RS02545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UA74_RS02550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UA74_RS02555	COG0649	NAD binding
UA74_RS02565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
UA74_RS02570	COG1034	ATP synthesis coupled electron transport
UA74_RS02575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
UA74_RS02580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UA74_RS02585	COG0839	Belongs to the complex I subunit 6 family
UA74_RS02590	COG0713	ATP synthesis coupled electron transport
UA74_RS02605	COG1007	ATP synthesis coupled electron transport
UA74_RS02610	COG0142	geranyltranstransferase activity
UA74_RS02630	COG1013	pyruvate-flavodoxin oxidoreductase activity
UA74_RS02635	COG0674	pyruvate-flavodoxin oxidoreductase activity
UA74_RS02635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UA74_RS02640	COG1522	sequence-specific DNA binding
UA74_RS02645	COG1834	amidinotransferase
UA74_RS02650	COG2205	protein histidine kinase activity
UA74_RS02655	COG0745	RESPONSE REGULATOR receiver
UA74_RS02670	COG0577	efflux transmembrane transporter activity
UA74_RS02670	COG1136	(ABC) transporter
UA74_RS02675	COG0577	efflux transmembrane transporter activity
UA74_RS02675	COG1136	(ABC) transporter
UA74_RS02690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UA74_RS02740	COG0501	Belongs to the peptidase M48B family
UA74_RS02745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
UA74_RS02760	COG0702	epimerase
UA74_RS02775	COG1666	GTP binding
UA74_RS02795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UA74_RS02800	COG2030	dehydratase
UA74_RS02810	COG0436	Aminotransferase
UA74_RS02830	COG0081	regulation of translation
UA74_RS02840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UA74_RS02845	COG0222	ribosome binding
UA74_RS02850	COG0085	RNA polymerase activity
UA74_RS02855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UA74_RS02890	COG2197	response regulator
UA74_RS02905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UA74_RS02910	COG0049	tRNA binding
UA74_RS02915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UA74_RS02920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UA74_RS02925	COG0051	transcription antitermination factor activity, RNA binding
UA74_RS02930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UA74_RS02935	COG0088	Forms part of the polypeptide exit tunnel
UA74_RS02940	COG0089	rRNA binding
UA74_RS02945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UA74_RS02950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UA74_RS02955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UA74_RS02960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UA74_RS02965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UA74_RS02975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UA74_RS02980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UA74_RS02985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UA74_RS02990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UA74_RS03000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UA74_RS03005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UA74_RS03010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UA74_RS03015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UA74_RS03075	COG2226	methyltransferase
UA74_RS03090	COG0563	adenylate kinase activity
UA74_RS03110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UA74_RS03115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UA74_RS03120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UA74_RS03125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UA74_RS03130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UA74_RS03135	COG0202	RNA polymerase activity
UA74_RS03140	COG0203	ribosomal protein L17
UA74_RS03145	COG0101	tRNA pseudouridine synthase activity
UA74_RS03165	COG4585	Histidine kinase
UA74_RS03170	COG3629	intracellular signal transduction
UA74_RS03170	COG3903	Transcriptional regulator
UA74_RS03175	COG0456	acetyltransferase
UA74_RS03205	COG2860	membrane
UA74_RS03210	COG0745	RESPONSE REGULATOR receiver
UA74_RS03215	COG2205	protein histidine kinase activity
UA74_RS03225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UA74_RS03230	COG0315	cyclic pyranopterin monophosphate synthase activity
UA74_RS03230	COG0521	Mo-molybdopterin cofactor biosynthetic process
UA74_RS03245	COG1970	mechanosensitive ion channel activity
UA74_RS03260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UA74_RS03270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UA74_RS03280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UA74_RS03320	COG4989	oxidoreductase activity
UA74_RS03405	COG3850	Histidine kinase
UA74_RS03435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UA74_RS03440	COG0084	hydrolase, TatD family'
UA74_RS03445	COG1652	LysM domain
UA74_RS03450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS03465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UA74_RS03540	COG1595	DNA-templated transcription, initiation
UA74_RS03545	COG1252	NADH dehydrogenase
UA74_RS03550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UA74_RS03555	COG2011	ABC-type metal ion transport system permease component
UA74_RS03560	COG1464	Belongs to the NlpA lipoprotein family
UA74_RS03575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
UA74_RS03580	COG2814	Major facilitator Superfamily
UA74_RS03585	COG2211	Major facilitator Superfamily
UA74_RS03590	COG0488	(ABC) transporter
UA74_RS03615	COG0193	aminoacyl-tRNA hydrolase activity
UA74_RS03630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UA74_RS03645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UA74_RS03665	COG1309	transcriptional regulator
UA74_RS03680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UA74_RS03700	COG2610	gluconate transmembrane transporter activity
UA74_RS03705	COG0129	dihydroxy-acid dehydratase activity
UA74_RS03715	COG0793	Belongs to the peptidase S41A family
UA74_RS03715	COG4946	Tricorn protease homolog
UA74_RS03740	COG0148	phosphopyruvate hydratase activity
UA74_RS03795	COG0714	Associated with various cellular activities
UA74_RS03810	COG1252	NADH dehydrogenase
UA74_RS03850	COG0183	Belongs to the thiolase family
UA74_RS03855	COG2755	lipolytic protein G-D-S-L family
UA74_RS03875	COG1414	Transcriptional regulator
UA74_RS03900	COG1175	transmembrane transport
UA74_RS03905	COG0395	ABC-type sugar transport system, permease component
UA74_RS03920	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS03975	COG3386	PFAM SMP-30 Gluconolaconase
UA74_RS03985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UA74_RS04005	COG3185	4-Hydroxyphenylpyruvate dioxygenase
UA74_RS04015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UA74_RS04025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UA74_RS04035	COG2226	methyltransferase
UA74_RS04040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UA74_RS04065	COG1733	regulation of RNA biosynthetic process
UA74_RS04070	COG1331	Highly conserved protein containing a thioredoxin domain
UA74_RS04100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UA74_RS04110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UA74_RS04120	COG0584	glycerophosphoryl diester phosphodiesterase
UA74_RS04125	COG0114	fumarate hydratase activity
UA74_RS04130	COG0492	ferredoxin-NADP+ reductase activity
UA74_RS04175	COG1722	exodeoxyribonuclease VII activity
UA74_RS04185	COG1570	exodeoxyribonuclease VII activity
UA74_RS04210	COG0420	3'-5' exonuclease activity
UA74_RS04215	COG0419	ATPase involved in DNA repair
UA74_RS04230	COG0012	GTP binding
UA74_RS04300	COG2154	pterin-4-alpha-carbinolamine dehydratase
UA74_RS04310	COG4149	molybdate abc transporter
UA74_RS04315	COG3842	ATPase activity
UA74_RS04350	COG0477	Major facilitator Superfamily
UA74_RS04370	COG1131	(ABC) transporter
UA74_RS04380	COG0745	RESPONSE REGULATOR receiver
UA74_RS04385	COG2205	protein histidine kinase activity
UA74_RS04395	COG1217	gtp-binding protein TYPA
UA74_RS04410	COG0601	transmembrane transport
UA74_RS04415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS04425	COG4608	Belongs to the ABC transporter superfamily
UA74_RS04430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UA74_RS04450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UA74_RS04465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UA74_RS04485	COG0655	NAD(P)H dehydrogenase (quinone) activity
UA74_RS04490	COG1611	Belongs to the LOG family
UA74_RS04495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UA74_RS04575	COG1024	Enoyl-CoA hydratase
UA74_RS04580	COG3327	negative regulation of DNA-templated transcription, initiation
UA74_RS04590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UA74_RS04595	COG0583	DNA-binding transcription factor activity
UA74_RS04600	COG2814	Major facilitator Superfamily
UA74_RS04605	COG0297	glycogen (starch) synthase activity
UA74_RS04610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UA74_RS04615	COG4122	O-methyltransferase activity
UA74_RS04630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UA74_RS04635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UA74_RS04650	COG2301	Belongs to the HpcH HpaI aldolase family
UA74_RS04705	COG0598	Magnesium transport protein CorA
UA74_RS04720	COG0613	PHP domain protein
UA74_RS04745	COG0513	Belongs to the DEAD box helicase family
UA74_RS04765	COG2267	carboxylic ester hydrolase activity
UA74_RS04805	COG0210	DNA helicase
UA74_RS04825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UA74_RS04855	COG0612	Peptidase, M16
UA74_RS04900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UA74_RS04920	COG3480	Lon protease (S16) C-terminal proteolytic domain
UA74_RS04930	COG1615	UPF0182 protein
UA74_RS04955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UA74_RS04960	COG2884	Cell division ATP-binding protein ftsE
UA74_RS04965	COG2177	Part of the ABC transporter FtsEX involved in
UA74_RS04970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UA74_RS04995	COG0640	Transcriptional regulator
UA74_RS05000	COG0586	Pfam SNARE associated Golgi protein
UA74_RS05015	COG0737	Belongs to the 5'-nucleotidase family
UA74_RS05025	COG1643	Atp-dependent helicase
UA74_RS05030	COG2814	Major facilitator Superfamily
UA74_RS05075	COG3421	Type III restriction
UA74_RS05080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
UA74_RS05135	COG1216	Glycosyl transferase, family 2
UA74_RS05155	COG0406	alpha-ribazole phosphatase activity
UA74_RS05180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UA74_RS05185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UA74_RS05195	COG1132	(ABC) transporter
UA74_RS05200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UA74_RS05205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UA74_RS05235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UA74_RS05245	COG2264	protein methyltransferase activity
UA74_RS05270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UA74_RS05280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UA74_RS05295	COG1253	flavin adenine dinucleotide binding
UA74_RS05300	COG1131	(ABC) transporter
UA74_RS05310	COG3851	Histidine kinase
UA74_RS05315	COG2197	response regulator
UA74_RS05320	COG1335	isochorismatase
UA74_RS05330	COG2197	response regulator
UA74_RS05350	COG1733	regulation of RNA biosynthetic process
UA74_RS05355	COG3321	synthase
UA74_RS05355	COG0604	alcohol dehydrogenase
UA74_RS05385	COG2267	carboxylic ester hydrolase activity
UA74_RS05390	COG0596	Alpha beta hydrolase
UA74_RS05395	COG4585	Histidine kinase
UA74_RS05400	COG2197	response regulator
UA74_RS05410	COG4221	oxidoreductase activity
UA74_RS05485	COG1131	(ABC) transporter
UA74_RS05505	COG0477	Major facilitator Superfamily
UA74_RS05515	COG1309	transcriptional regulator
UA74_RS05535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UA74_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS05590	COG0583	DNA-binding transcription factor activity
UA74_RS05595	COG2226	methyltransferase
UA74_RS05705	COG1414	Transcriptional regulator
UA74_RS05710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UA74_RS05715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UA74_RS05720	COG2815	serine threonine protein kinase
UA74_RS05720	COG0515	serine threonine protein kinase
UA74_RS05755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
UA74_RS05770	COG1819	glycosyl
UA74_RS05800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UA74_RS05805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UA74_RS05810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
UA74_RS05815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UA74_RS05820	COG0778	Nitroreductase
UA74_RS05830	COG0596	Alpha beta hydrolase
UA74_RS05835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UA74_RS05840	COG0736	holo-[acyl-carrier-protein] synthase activity
UA74_RS05865	COG1131	(ABC) transporter
UA74_RS05870	COG1511	domain protein
UA74_RS05870	COG0842	Transport permease protein
UA74_RS05890	COG2197	response regulator
UA74_RS05940	COG0702	epimerase
UA74_RS05945	COG2124	cytochrome p450
UA74_RS05955	COG1937	Protein conserved in bacteria
UA74_RS05965	COG2217	Heavy metal translocating P-type atpase
UA74_RS05985	COG0110	maltose O-acetyltransferase activity
UA74_RS06000	COG0006	proline dipeptidase activity
UA74_RS06130	COG0346	lactoylglutathione lyase activity
UA74_RS06135	COG2207	Transcriptional regulator
UA74_RS06160	COG2197	response regulator
UA74_RS06165	COG3851	Histidine kinase
UA74_RS06180	COG1136	(ABC) transporter
UA74_RS06185	COG0577	efflux transmembrane transporter activity
UA74_RS06210	COG2936	dipeptidyl-peptidase activity
UA74_RS06230	COG5001	Diguanylate cyclase
UA74_RS06245	COG0560	Phosphoserine phosphatase
UA74_RS06245	COG3830	Belongs to the UPF0237 family
UA74_RS06260	COG1268	BioY protein
UA74_RS06265	COG1335	isochorismatase
UA74_RS06275	COG0604	alcohol dehydrogenase
UA74_RS06285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UA74_RS06300	COG3191	aminopeptidase activity
UA74_RS06330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UA74_RS06340	COG0598	Magnesium transport protein CorA
UA74_RS06345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UA74_RS06350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UA74_RS06365	COG0058	SHG alpha-glucan phosphorylase activity
UA74_RS06455	COG1119	ATPase activity
UA74_RS06465	COG2226	methyltransferase
UA74_RS06475	COG3629	intracellular signal transduction
UA74_RS06475	COG3903	Transcriptional regulator
UA74_RS06495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UA74_RS06505	COG3467	pyridoxamine 5'-phosphate
UA74_RS06535	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UA74_RS06545	COG0482	sulfurtransferase activity
UA74_RS06570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UA74_RS06660	COG0488	(ABC) transporter
UA74_RS06675	COG2146	nitrite reductase [NAD(P)H] activity
UA74_RS06700	COG5297	Belongs to the glycosyl hydrolase family 6
UA74_RS06745	COG1376	ErfK ybiS ycfS ynhG family protein
UA74_RS06750	COG2124	cytochrome p450
UA74_RS06765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
UA74_RS06780	COG0318	PFAM AMP-dependent synthetase and ligase
UA74_RS06795	COG5006	permease, DMT superfamily
UA74_RS06805	COG0697	spore germination
UA74_RS06840	COG1175	transmembrane transport
UA74_RS06870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UA74_RS06875	COG0596	Alpha beta hydrolase
UA74_RS06895	COG1309	transcriptional regulator
UA74_RS06900	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS06930	COG1404	Belongs to the peptidase S8 family
UA74_RS06970	COG2814	Major facilitator Superfamily
UA74_RS07015	COG1917	Cupin 2, conserved barrel domain protein
UA74_RS07020	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
UA74_RS07040	COG1595	DNA-templated transcription, initiation
UA74_RS07065	COG0018	arginyl-trna synthetase
UA74_RS07070	COG0019	diaminopimelate decarboxylase activity
UA74_RS07075	COG0460	homoserine dehydrogenase
UA74_RS07080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UA74_RS07085	COG0083	homoserine kinase activity
UA74_RS07090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UA74_RS07090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UA74_RS07100	COG0254	rRNA binding
UA74_RS07105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UA74_RS07115	COG2890	protein-(glutamine-N5) methyltransferase activity
UA74_RS07130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UA74_RS07135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UA74_RS07145	COG0356	it plays a direct role in the translocation of protons across the membrane
UA74_RS07150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UA74_RS07155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UA74_RS07160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UA74_RS07165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UA74_RS07170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UA74_RS07185	COG1595	DNA-templated transcription, initiation
UA74_RS07190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UA74_RS07215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
UA74_RS07220	COG0765	amino acid transport
UA74_RS07225	COG0765	amino acid transport
UA74_RS07230	COG1126	abc transporter atp-binding protein
UA74_RS07245	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
UA74_RS07270	COG2376	Dihydroxyacetone kinase
UA74_RS07280	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
UA74_RS07305	COG0346	lactoylglutathione lyase activity
UA74_RS07315	COG0183	Belongs to the thiolase family
UA74_RS07330	COG2409	Drug exporters of the RND superfamily
UA74_RS07335	COG1846	Transcriptional regulator
UA74_RS07345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UA74_RS07345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UA74_RS07370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UA74_RS07375	COG0366	Alpha amylase catalytic
UA74_RS07390	COG1051	belongs to the nudix hydrolase family
UA74_RS07435	COG1609	Transcriptional regulator
UA74_RS07450	COG4209	transmembrane transport
UA74_RS07455	COG0395	ABC-type sugar transport system, permease component
UA74_RS07485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS07500	COG0640	Transcriptional regulator
UA74_RS07565	COG4585	Histidine kinase
UA74_RS07570	COG2197	response regulator
UA74_RS07590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UA74_RS07610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UA74_RS07615	COG3281	Trehalose synthase
UA74_RS07620	COG0366	Alpha amylase catalytic
UA74_RS07640	COG0667	Aldo Keto reductase
UA74_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS07695	COG0693	protein deglycase activity
UA74_RS07720	COG1309	transcriptional regulator
UA74_RS07725	COG2272	Belongs to the type-B carboxylesterase lipase family
UA74_RS07830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UA74_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS07885	COG3831	ATPase activity
UA74_RS07900	COG2205	protein histidine kinase activity
UA74_RS07905	COG0745	RESPONSE REGULATOR receiver
UA74_RS07970	COG2902	Dehydrogenase
UA74_RS07985	COG0366	Alpha amylase catalytic
UA74_RS07995	COG0668	transmembrane transport
UA74_RS08020	COG1505	serine-type exopeptidase activity
UA74_RS08040	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UA74_RS08050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UA74_RS08095	COG4552	Acetyltransferase involved in intracellular survival and related
UA74_RS08120	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
UA74_RS08135	COG1309	transcriptional regulator
UA74_RS08165	COG0544	peptidyl-prolyl cis-trans isomerase activity
UA74_RS08170	COG0740	serine-type endopeptidase activity
UA74_RS08175	COG0740	serine-type endopeptidase activity
UA74_RS08200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UA74_RS08220	COG0525	valine-tRNA ligase activity
UA74_RS08225	COG0285	dihydrofolate synthase activity
UA74_RS08235	COG0105	UTP biosynthetic process
UA74_RS08245	COG0842	Transport permease protein
UA74_RS08250	COG0842	Transport permease protein
UA74_RS08260	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
UA74_RS08280	COG1530	ribonuclease E activity
UA74_RS08280	COG1530	ribonuclease E activity
UA74_RS08305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UA74_RS08315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UA74_RS08320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UA74_RS08330	COG0514	ATP-dependent DNA helicase (RecQ)
UA74_RS08335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UA74_RS08355	COG0799	negative regulation of ribosome biogenesis
UA74_RS08365	COG2755	lipolytic protein G-D-S-L family
UA74_RS08370	COG1307	EDD domain protein, DegV family
UA74_RS08375	COG1555	photosystem II stabilization
UA74_RS08385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UA74_RS08395	COG0268	Binds directly to 16S ribosomal RNA
UA74_RS08410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UA74_RS08445	COG1490	D-aminoacyl-tRNA deacylase activity
UA74_RS08450	COG0204	Acyl-transferase
UA74_RS08450	COG0318	PFAM AMP-dependent synthetase and ligase
UA74_RS08465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UA74_RS08470	COG2313	pseudouridylate synthase activity
UA74_RS08505	COG4214	carbohydrate transport
UA74_RS08510	COG1940	carbohydrate kinase activity
UA74_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS08530	COG1940	carbohydrate kinase activity
UA74_RS08535	COG0483	inositol monophosphate 1-phosphatase activity
UA74_RS08555	COG0756	dUTP diphosphatase activity
UA74_RS08580	COG0569	domain protein
UA74_RS08585	COG0531	amino acid
UA74_RS08590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UA74_RS08595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UA74_RS08605	COG0745	RESPONSE REGULATOR receiver
UA74_RS08610	COG2205	protein histidine kinase activity
UA74_RS08615	COG1231	oxidoreductase activity
UA74_RS08630	COG0481	GTPase activity
UA74_RS08635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UA74_RS08640	COG2137	regulation of response to DNA damage stimulus
UA74_RS08650	COG0800	Aldolase
UA74_RS08670	COG0765	amino acid transport
UA74_RS08675	COG0765	amino acid transport
UA74_RS08685	COG1126	abc transporter atp-binding protein
UA74_RS08690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UA74_RS08700	COG1196	nuclear chromosome segregation
UA74_RS08710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UA74_RS08725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UA74_RS08735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UA74_RS08745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UA74_RS08750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UA74_RS08785	COG2186	Transcriptional regulator
UA74_RS08790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UA74_RS08795	COG3395	kinase activity
UA74_RS08815	COG0823	Involved in the tonB-independent uptake of proteins
UA74_RS08815	COG1506	peptidase
UA74_RS08825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
UA74_RS08845	COG0123	including yeast histone deacetylase and acetoin utilization protein
UA74_RS08865	COG5002	protein histidine kinase activity
UA74_RS08870	COG0745	RESPONSE REGULATOR receiver
UA74_RS08885	COG3265	gluconokinase activity
UA74_RS08925	COG0228	four-way junction DNA binding
UA74_RS08935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UA74_RS08940	COG0336	Belongs to the RNA methyltransferase TrmD family
UA74_RS08945	COG0335	large ribosomal subunit rRNA binding
UA74_RS08950	COG0681	Belongs to the peptidase S26 family
UA74_RS08955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UA74_RS08975	COG0601	transmembrane transport
UA74_RS08980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS08985	COG0444	Belongs to the ABC transporter superfamily
UA74_RS08990	COG4608	Belongs to the ABC transporter superfamily
UA74_RS09005	COG0792	nuclease activity
UA74_RS09025	COG1191	sigma factor activity
UA74_RS09035	COG0052	Belongs to the universal ribosomal protein uS2 family
UA74_RS09040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UA74_RS09045	COG0528	UMP kinase activity
UA74_RS09050	COG0233	cytoplasmic translational termination
UA74_RS09060	COG2226	methyltransferase
UA74_RS09065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UA74_RS09080	COG3842	ATPase activity
UA74_RS09090	COG1176	ABC-type spermidine putrescine transport system, permease component I
UA74_RS09095	COG1177	transmembrane transport
UA74_RS09100	COG2261	transglycosylase associated protein
UA74_RS09105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UA74_RS09115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UA74_RS09135	COG1492	cobalamin metabolic process
UA74_RS09155	COG2807	transmembrane transport
UA74_RS09170	COG1881	PFAM PEBP family protein
UA74_RS09185	COG4585	Histidine kinase
UA74_RS09190	COG2197	response regulator
UA74_RS09255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UA74_RS09255	COG1648	precorrin-2 dehydrogenase activity
UA74_RS09260	COG0513	Belongs to the DEAD box helicase family
UA74_RS09270	COG3022	response to hydroperoxide
UA74_RS09280	COG0442	prolyl-tRNA aminoacylation
UA74_RS09290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UA74_RS09315	COG0779	Required for maturation of 30S ribosomal subunits
UA74_RS09330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UA74_RS09340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UA74_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS09425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UA74_RS09450	COG2146	nitrite reductase [NAD(P)H] activity
UA74_RS09450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UA74_RS09455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UA74_RS09455	COG2146	nitrite reductase [NAD(P)H] activity
UA74_RS09460	COG2223	nitrite transmembrane transporter activity
UA74_RS09465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UA74_RS09470	COG0243	molybdopterin cofactor binding
UA74_RS09475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UA74_RS09480	COG1185	polyribonucleotide nucleotidyltransferase activity
UA74_RS09485	COG0612	Peptidase, M16
UA74_RS09490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UA74_RS09515	COG2274	protein secretion by the type I secretion system
UA74_RS09545	COG3214	Protein conserved in bacteria
UA74_RS09565	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
UA74_RS09570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UA74_RS09575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UA74_RS09580	COG1674	ftsk spoiiie
UA74_RS09590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UA74_RS09600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UA74_RS09610	COG1546	Belongs to the CinA family
UA74_RS09610	COG1058	Belongs to the CinA family
UA74_RS09615	COG1396	sequence-specific DNA binding
UA74_RS09625	COG1842	Phage shock protein A
UA74_RS09635	COG2233	PERMEase
UA74_RS09640	COG1192	Involved in chromosome partitioning
UA74_RS09655	COG1305	Transglutaminase-like
UA74_RS09665	COG0714	Associated with various cellular activities
UA74_RS09675	COG2001	Belongs to the MraZ family
UA74_RS09680	COG0275	rRNA processing
UA74_RS09695	COG0768	penicillin binding
UA74_RS09710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UA74_RS09715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UA74_RS09725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UA74_RS09730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UA74_RS09735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UA74_RS09740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UA74_RS09750	COG1984	allophanate hydrolase subunit 2
UA74_RS09760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UA74_RS09770	COG1070	Carbohydrate kinase
UA74_RS09785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UA74_RS09790	COG1799	cell septum assembly
UA74_RS09800	COG3599	regulation of cell shape
UA74_RS09805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UA74_RS09835	COG1309	transcriptional regulator
UA74_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS09870	COG2124	cytochrome p450
UA74_RS09875	COG2124	cytochrome p450
UA74_RS09880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UA74_RS09885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UA74_RS09895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UA74_RS09920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UA74_RS09925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UA74_RS09960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS09970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UA74_RS09975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UA74_RS09980	COG2318	DinB family
UA74_RS10000	COG0446	pyridine nucleotide-disulphide oxidoreductase
UA74_RS10010	COG0131	Imidazoleglycerol-phosphate dehydratase
UA74_RS10020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UA74_RS10030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UA74_RS10050	COG0107	imidazoleglycerol-phosphate synthase activity
UA74_RS10060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UA74_RS10105	COG1309	transcriptional regulator
UA74_RS10120	COG0134	indole-3-glycerol-phosphate synthase activity
UA74_RS10125	COG0133	tryptophan synthase activity
UA74_RS10130	COG0159	tryptophan synthase activity
UA74_RS10140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UA74_RS10145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UA74_RS10155	COG1160	GTP binding
UA74_RS10185	COG2188	Transcriptional regulator
UA74_RS10195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UA74_RS10200	COG1280	lysine exporter protein (LysE YggA)
UA74_RS10225	COG0142	geranyltranstransferase activity
UA74_RS10250	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS10255	COG0179	Fumarylacetoacetate (FAA) hydrolase
UA74_RS10275	COG0110	maltose O-acetyltransferase activity
UA74_RS10315	COG0732	type I restriction modification DNA specificity domain
UA74_RS10325	COG2815	serine threonine protein kinase
UA74_RS10325	COG0515	serine threonine protein kinase
UA74_RS10340	COG4941	Belongs to the sigma-70 factor family
UA74_RS10345	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
UA74_RS10360	COG1733	regulation of RNA biosynthetic process
UA74_RS10365	COG0671	phosphoesterase, PA-phosphatase related
UA74_RS10375	COG1196	nuclear chromosome segregation
UA74_RS10375	COG0741	lytic transglycosylase activity
UA74_RS10375	COG0739	heme binding
UA74_RS10380	COG0154	amidase activity
UA74_RS10390	COG1522	sequence-specific DNA binding
UA74_RS10400	COG0156	8-amino-7-oxononanoate synthase activity
UA74_RS10460	COG0438	transferase activity, transferring glycosyl groups
UA74_RS10475	COG1088	dTDP-glucose 4,6-dehydratase activity
UA74_RS10480	COG2192	nodulation
UA74_RS10490	COG0859	PFAM glycosyl transferase family 9
UA74_RS10495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UA74_RS10500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
UA74_RS10500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UA74_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS10515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UA74_RS10535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UA74_RS10540	COG0789	Transcriptional regulator
UA74_RS10545	COG0659	secondary active sulfate transmembrane transporter activity
UA74_RS10560	COG0667	Aldo Keto reductase
UA74_RS10595	COG0589	response to stress
UA74_RS10610	COG0514	ATP-dependent DNA helicase (RecQ)
UA74_RS10625	COG1966	Carbon starvation protein
UA74_RS10635	COG0003	Pfam Anion-transporting ATPase
UA74_RS10650	COG1120	ATPase activity
UA74_RS10700	COG2050	protein possibly involved in aromatic compounds catabolism
UA74_RS10730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UA74_RS10735	COG0539	negative regulation of cytoplasmic translation
UA74_RS10740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UA74_RS10740	COG2755	lipolytic protein G-D-S-L family
UA74_RS10745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UA74_RS10745	COG2755	lipolytic protein G-D-S-L family
UA74_RS10750	COG0237	dephospho-CoA kinase activity
UA74_RS10750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UA74_RS10780	COG1131	(ABC) transporter
UA74_RS10790	COG1228	amidohydrolase
UA74_RS10795	COG1506	peptidase
UA74_RS10795	COG0823	Involved in the tonB-independent uptake of proteins
UA74_RS10795	COG4946	Tricorn protease homolog
UA74_RS10835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UA74_RS10840	COG1560	Kdo2-lipid A biosynthetic process
UA74_RS10845	COG0438	transferase activity, transferring glycosyl groups
UA74_RS10850	COG1051	belongs to the nudix hydrolase family
UA74_RS10865	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
UA74_RS10880	COG1396	sequence-specific DNA binding
UA74_RS10895	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
UA74_RS10900	COG0217	transcriptional regulatory protein
UA74_RS10910	COG3629	intracellular signal transduction
UA74_RS10915	COG3629	intracellular signal transduction
UA74_RS10915	COG3903	Transcriptional regulator
UA74_RS10920	COG2124	cytochrome p450
UA74_RS10925	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS10940	COG2132	Multicopper oxidase
UA74_RS10950	COG3104	oligopeptide transport
UA74_RS10965	COG2084	Dehydrogenase
UA74_RS10980	COG0475	glutathione-regulated potassium exporter activity
UA74_RS10985	COG2345	Transcriptional regulator
UA74_RS10990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UA74_RS10995	COG2345	Transcriptional regulator
UA74_RS11020	COG0702	epimerase
UA74_RS11045	COG0367	asparagine synthase
UA74_RS11050	COG1819	glycosyl
UA74_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS11070	COG0662	Cupin 2, conserved barrel domain protein
UA74_RS11075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UA74_RS11080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UA74_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS11115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UA74_RS11115	COG0825	malonyl-CoA metabolic process
UA74_RS11120	COG0511	ligase activity, forming carbon-carbon bonds
UA74_RS11125	COG0439	Biotin carboxylase
UA74_RS11145	COG0346	lactoylglutathione lyase activity
UA74_RS11155	COG0632	four-way junction helicase activity
UA74_RS11160	COG2255	four-way junction helicase activity
UA74_RS11170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UA74_RS11175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UA74_RS11180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UA74_RS11220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UA74_RS11240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UA74_RS11245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
UA74_RS11275	COG4412	M6 family metalloprotease domain protein
UA74_RS11275	COG1404	Belongs to the peptidase S8 family
UA74_RS11280	COG4412	M6 family metalloprotease domain protein
UA74_RS11280	COG1404	Belongs to the peptidase S8 family
UA74_RS11310	COG1404	Belongs to the peptidase S8 family
UA74_RS11310	COG4412	M6 family metalloprotease domain protein
UA74_RS11325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UA74_RS11335	COG1733	regulation of RNA biosynthetic process
UA74_RS11345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UA74_RS11350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UA74_RS11350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UA74_RS11355	COG0803	Belongs to the bacterial solute-binding protein 9 family
UA74_RS11360	COG1121	(ABC) transporter
UA74_RS11365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UA74_RS11365	COG1321	iron dependent repressor
UA74_RS11370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UA74_RS11375	COG2132	Multicopper oxidase
UA74_RS11380	COG1309	transcriptional regulator
UA74_RS11395	COG1607	acyl-coa hydrolase
UA74_RS11400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UA74_RS11415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UA74_RS11440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UA74_RS11460	COG1716	ATPase activity
UA74_RS11480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UA74_RS11480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UA74_RS11485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UA74_RS11505	COG3104	oligopeptide transport
UA74_RS11510	COG1309	transcriptional regulator
UA74_RS11515	COG3572	ergothioneine biosynthetic process
UA74_RS11520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UA74_RS11525	COG0121	glutamine amidotransferase
UA74_RS11530	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
UA74_RS11550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UA74_RS11570	COG0791	NLP P60 protein
UA74_RS11570	COG3883	PFAM NLP P60 protein
UA74_RS11575	COG0583	DNA-binding transcription factor activity
UA74_RS11580	COG0697	spore germination
UA74_RS11595	COG0714	Associated with various cellular activities
UA74_RS11605	COG2304	oxidoreductase activity
UA74_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS11615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UA74_RS11620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UA74_RS11665	COG1012	belongs to the aldehyde dehydrogenase family
UA74_RS11700	COG3473	Maleate cis-trans isomerase
UA74_RS11710	COG2186	Transcriptional regulator
UA74_RS11720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UA74_RS11730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UA74_RS11755	COG1716	ATPase activity
UA74_RS11775	COG0183	Belongs to the thiolase family
UA74_RS11780	COG1253	flavin adenine dinucleotide binding
UA74_RS11795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UA74_RS11800	COG0297	glycogen (starch) synthase activity
UA74_RS11845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UA74_RS11850	COG0542	response to heat
UA74_RS11910	COG1653	transport
UA74_RS11920	COG2186	Transcriptional regulator
UA74_RS11925	COG3401	FG-GAP repeat protein
UA74_RS12005	COG0508	dehydrogenase complex catalyzes the overall conversion of
UA74_RS12010	COG0022	dehydrogenase e1 component
UA74_RS12015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UA74_RS12020	COG0789	Transcriptional regulator
UA74_RS12040	COG1643	Atp-dependent helicase
UA74_RS12060	COG2259	Doxx family
UA74_RS12075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UA74_RS12085	COG0662	Cupin 2, conserved barrel domain protein
UA74_RS12130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UA74_RS12145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UA74_RS12185	COG1263	PTS System
UA74_RS12190	COG2188	Transcriptional regulator
UA74_RS12195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UA74_RS12195	COG1263	PTS System
UA74_RS12200	COG2190	(PTS) system
UA74_RS12215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UA74_RS12220	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UA74_RS12230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UA74_RS12235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UA74_RS12240	COG0346	lactoylglutathione lyase activity
UA74_RS12255	COG0006	proline dipeptidase activity
UA74_RS12260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UA74_RS12265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UA74_RS12275	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UA74_RS12280	COG0540	Belongs to the ATCase OTCase family
UA74_RS12295	COG0505	Belongs to the CarA family
UA74_RS12305	COG0284	orotidine-5'-phosphate decarboxylase activity
UA74_RS12320	COG1758	RNA polymerase activity
UA74_RS12330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UA74_RS12365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UA74_RS12370	COG0242	peptide deformylase activity
UA74_RS12385	COG2040	homocysteine
UA74_RS12400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UA74_RS12400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UA74_RS12405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UA74_RS12420	COG0322	excinuclease ABC activity
UA74_RS12425	COG1660	Displays ATPase and GTPase activities
UA74_RS12435	COG1481	regulation of sporulation
UA74_RS12440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UA74_RS12445	COG0126	phosphoglycerate kinase activity
UA74_RS12450	COG0149	triose-phosphate isomerase activity
UA74_RS12455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UA74_RS12485	COG0363	glucosamine-6-phosphate deaminase activity
UA74_RS12500	COG0166	Belongs to the GPI family
UA74_RS12505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UA74_RS12515	COG0109	protoheme IX farnesyltransferase activity
UA74_RS12550	COG0477	Major facilitator Superfamily
UA74_RS12580	COG1510	regulation of RNA biosynthetic process
UA74_RS12595	COG1131	(ABC) transporter
UA74_RS12620	COG2146	nitrite reductase [NAD(P)H] activity
UA74_RS12625	COG0396	ATPase activity
UA74_RS12640	COG2151	metal-sulfur cluster biosynthetic enzyme
UA74_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS12710	COG0488	(ABC) transporter
UA74_RS12720	COG1024	Enoyl-CoA hydratase
UA74_RS12730	COG1733	regulation of RNA biosynthetic process
UA74_RS12765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UA74_RS12795	COG1063	alcohol dehydrogenase
UA74_RS12830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UA74_RS12840	COG1657	PFAM Prenyltransferase squalene oxidase
UA74_RS12845	COG0142	geranyltranstransferase activity
UA74_RS12870	COG0515	serine threonine protein kinase
UA74_RS12880	COG1505	serine-type exopeptidase activity
UA74_RS12890	COG0140	phosphoribosyl-ATP diphosphatase activity
UA74_RS12895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UA74_RS12900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
UA74_RS12905	COG2329	Antibiotic biosynthesis monooxygenase
UA74_RS12910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UA74_RS12950	COG1222	aaa ATPase
UA74_RS12985	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
UA74_RS12990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
UA74_RS13005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
UA74_RS13015	COG2378	regulation of single-species biofilm formation
UA74_RS13045	COG4552	Acetyltransferase involved in intracellular survival and related
UA74_RS13080	COG1136	(ABC) transporter
UA74_RS13085	COG0577	efflux transmembrane transporter activity
UA74_RS13085	COG1136	(ABC) transporter
UA74_RS13095	COG3030	protein affecting phage T7 exclusion by the F plasmid
UA74_RS13100	COG1574	metal-dependent hydrolase with the TIM-barrel fold
UA74_RS13110	COG0745	RESPONSE REGULATOR receiver
UA74_RS13130	COG0667	Aldo Keto reductase
UA74_RS13170	COG3845	ABC transporter
UA74_RS13180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UA74_RS13230	COG0515	serine threonine protein kinase
UA74_RS13245	COG3285	dna ligase
UA74_RS13245	COG1793	dna ligase
UA74_RS13255	COG0517	IMP dehydrogenase activity
UA74_RS13270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UA74_RS13280	COG0385	Bile acid
UA74_RS13295	COG0515	serine threonine protein kinase
UA74_RS13305	COG1132	(ABC) transporter
UA74_RS13310	COG1132	(ABC) transporter
UA74_RS13315	COG2855	membrane
UA74_RS13325	COG4607	ABC-type enterochelin transport system periplasmic component
UA74_RS13330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS13335	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS13340	COG1120	ATPase activity
UA74_RS13345	COG1132	(ABC) transporter
UA74_RS13350	COG1132	(ABC) transporter
UA74_RS13415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UA74_RS13420	COG1309	transcriptional regulator
UA74_RS13425	COG1879	ABC-type sugar transport system periplasmic component
UA74_RS13430	COG1129	ABC transporter
UA74_RS13435	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS13440	COG1063	alcohol dehydrogenase
UA74_RS13460	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS13465	COG0800	Aldolase
UA74_RS13470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UA74_RS13475	COG1309	transcriptional regulator
UA74_RS13485	COG2318	DinB family
UA74_RS13495	COG1396	sequence-specific DNA binding
UA74_RS13525	COG0583	DNA-binding transcription factor activity
UA74_RS13545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UA74_RS13555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UA74_RS13590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UA74_RS13635	COG1960	acyl-CoA dehydrogenase activity
UA74_RS13640	COG0318	PFAM AMP-dependent synthetase and ligase
UA74_RS13655	COG2508	Transcriptional regulator
UA74_RS13670	COG0183	Belongs to the thiolase family
UA74_RS13675	COG1960	acyl-CoA dehydrogenase activity
UA74_RS13700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
UA74_RS13705	COG0235	Class ii aldolase
UA74_RS13710	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
UA74_RS13715	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
UA74_RS13730	COG1079	Belongs to the binding-protein-dependent transport system permease family
UA74_RS13735	COG1079	Belongs to the binding-protein-dependent transport system permease family
UA74_RS13740	COG3845	ABC transporter
UA74_RS13765	COG0583	DNA-binding transcription factor activity
UA74_RS13770	COG1309	transcriptional regulator
UA74_RS13775	COG1132	(ABC) transporter
UA74_RS13795	COG2018	Roadblock/LC7 domain
UA74_RS13810	COG1595	DNA-templated transcription, initiation
UA74_RS13905	COG1518	maintenance of DNA repeat elements
UA74_RS13910	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
UA74_RS13965	COG0673	inositol 2-dehydrogenase activity
UA74_RS13970	COG1116	anion transmembrane transporter activity
UA74_RS13980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UA74_RS14005	COG3903	Transcriptional regulator
UA74_RS14005	COG3629	intracellular signal transduction
UA74_RS14035	COG0477	Major facilitator Superfamily
UA74_RS14040	COG2362	D-Aminopeptidase
UA74_RS14050	COG0601	transmembrane transport
UA74_RS14055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS14075	COG1278	Cold shock
UA74_RS14085	COG2264	protein methyltransferase activity
UA74_RS14095	COG1619	proteins homologs of microcin C7 resistance protein MccF
UA74_RS14145	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
UA74_RS14165	COG2197	response regulator
UA74_RS14170	COG4585	Histidine kinase
UA74_RS14205	COG0215	cysteine-tRNA ligase activity
UA74_RS14220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
UA74_RS14225	COG2076	Multidrug Resistance protein
UA74_RS14235	COG1410	methionine synthase
UA74_RS14235	COG0646	methionine synthase
UA74_RS14245	COG0546	phosphoglycolate phosphatase activity
UA74_RS14255	COG0372	Belongs to the citrate synthase family
UA74_RS14270	COG1515	deoxyribonuclease V activity
UA74_RS14275	COG0242	peptide deformylase activity
UA74_RS14285	COG0640	Transcriptional regulator
UA74_RS14295	COG0477	Major facilitator Superfamily
UA74_RS14300	COG1132	(ABC) transporter
UA74_RS14325	COG0235	Class ii aldolase
UA74_RS14330	COG3395	kinase activity
UA74_RS14350	COG1349	DNA-binding transcription factor activity
UA74_RS14365	COG1309	transcriptional regulator
UA74_RS14375	COG3384	dioxygenase
UA74_RS14405	COG2814	Major facilitator Superfamily
UA74_RS14420	COG0076	glutamate decarboxylase activity
UA74_RS14445	COG3291	Pkd domain containing protein
UA74_RS14445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
UA74_RS14470	COG0277	FAD linked oxidase domain protein
UA74_RS14475	COG1686	Belongs to the peptidase S11 family
UA74_RS14495	COG1012	belongs to the aldehyde dehydrogenase family
UA74_RS14520	COG1785	Belongs to the alkaline phosphatase family
UA74_RS14530	COG0009	L-threonylcarbamoyladenylate synthase
UA74_RS14535	COG1120	ATPase activity
UA74_RS14540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS14545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS14575	COG0477	Major facilitator Superfamily
UA74_RS14585	COG1309	transcriptional regulator
UA74_RS14590	COG2027	D-alanyl-D-alanine carboxypeptidase
UA74_RS14595	COG0488	(ABC) transporter
UA74_RS14600	COG0583	DNA-binding transcription factor activity
UA74_RS14625	COG1063	alcohol dehydrogenase
UA74_RS14635	COG0400	carboxylic ester hydrolase activity
UA74_RS14640	COG0346	lactoylglutathione lyase activity
UA74_RS14645	COG0655	NAD(P)H dehydrogenase (quinone) activity
UA74_RS14650	COG1846	Transcriptional regulator
UA74_RS14655	COG1649	PFAM Uncharacterised BCR, COG1649
UA74_RS14670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UA74_RS14730	COG0667	Aldo Keto reductase
UA74_RS14755	COG2267	carboxylic ester hydrolase activity
UA74_RS14760	COG2226	methyltransferase
UA74_RS14765	COG0488	(ABC) transporter
UA74_RS14770	COG1739	Uncharacterized protein family UPF0029
UA74_RS14785	COG4565	transcriptional regulatory protein
UA74_RS14815	COG0463	Glycosyl transferase, family 2
UA74_RS14825	COG1435	thymidine kinase activity
UA74_RS14830	COG2270	Major facilitator Superfamily
UA74_RS14845	COG3300	MHYT domain
UA74_RS14845	COG5001	Diguanylate cyclase
UA74_RS14860	COG4974	Belongs to the 'phage' integrase family
UA74_RS14885	COG3629	intracellular signal transduction
UA74_RS14885	COG3903	Transcriptional regulator
UA74_RS14945	COG0702	epimerase
UA74_RS14975	COG1132	(ABC) transporter
UA74_RS15000	COG0492	ferredoxin-NADP+ reductase activity
UA74_RS15010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UA74_RS15030	COG0789	Transcriptional regulator
UA74_RS15045	COG1960	acyl-CoA dehydrogenase activity
UA74_RS15055	COG1846	Transcriptional regulator
UA74_RS15060	COG0446	pyridine nucleotide-disulphide oxidoreductase
UA74_RS15075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UA74_RS15080	COG0702	epimerase
UA74_RS15100	COG0477	Major facilitator Superfamily
UA74_RS15125	COG0702	epimerase
UA74_RS15130	COG1733	regulation of RNA biosynthetic process
UA74_RS15140	COG1309	transcriptional regulator
UA74_RS15155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UA74_RS15160	COG1357	PFAM Pentapeptide repeats (8 copies)
UA74_RS15165	COG1309	transcriptional regulator
UA74_RS15175	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS15220	COG0741	lytic transglycosylase activity
UA74_RS15220	COG0739	heme binding
UA74_RS15220	COG1196	nuclear chromosome segregation
UA74_RS15235	COG1309	transcriptional regulator
UA74_RS15295	COG2267	carboxylic ester hydrolase activity
UA74_RS15305	COG1309	transcriptional regulator
UA74_RS15325	COG4941	Belongs to the sigma-70 factor family
UA74_RS15330	COG3795	YCII-related domain
UA74_RS15340	COG0346	lactoylglutathione lyase activity
UA74_RS15370	COG0697	spore germination
UA74_RS15380	COG2205	protein histidine kinase activity
UA74_RS15385	COG2197	response regulator
UA74_RS15410	COG3795	YCII-related domain
UA74_RS15415	COG4941	Belongs to the sigma-70 factor family
UA74_RS15420	COG0477	Major facilitator Superfamily
UA74_RS15465	COG3795	YCII-related domain
UA74_RS15480	COG1309	transcriptional regulator
UA74_RS15485	COG0583	DNA-binding transcription factor activity
UA74_RS15490	COG0439	Biotin carboxylase
UA74_RS15515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UA74_RS15535	COG0477	Major facilitator Superfamily
UA74_RS15540	COG0596	Alpha beta hydrolase
UA74_RS15540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UA74_RS15555	COG0667	Aldo Keto reductase
UA74_RS15565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UA74_RS15570	COG2365	Tyrosine phosphatase family
UA74_RS15575	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
UA74_RS15590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UA74_RS15600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UA74_RS15605	COG2890	protein-(glutamine-N5) methyltransferase activity
UA74_RS15650	COG2249	NAD(P)H dehydrogenase (quinone) activity
UA74_RS15655	COG0667	Aldo Keto reductase
UA74_RS15680	COG1902	pentaerythritol trinitrate reductase activity
UA74_RS15695	COG1968	undecaprenyl-diphosphatase activity
UA74_RS15700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UA74_RS15720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UA74_RS15785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UA74_RS15835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
UA74_RS15880	COG0318	PFAM AMP-dependent synthetase and ligase
UA74_RS15890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UA74_RS15895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UA74_RS15925	COG1203	CRISPR-associated helicase, Cas3
UA74_RS15935	COG1518	maintenance of DNA repeat elements
UA74_RS15945	COG0582	viral genome integration into host DNA
UA74_RS16005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
UA74_RS16020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
UA74_RS16030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
UA74_RS16085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UA74_RS16100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UA74_RS16130	COG0018	arginyl-trna synthetase
UA74_RS16160	COG3706	GGDEF domain
UA74_RS16245	COG0714	Associated with various cellular activities
UA74_RS16425	COG2801	Transposase and inactivated derivatives
UA74_RS16465	COG2197	response regulator
UA74_RS16480	COG1819	glycosyl
UA74_RS16485	COG3321	synthase
UA74_RS16485	COG0604	alcohol dehydrogenase
UA74_RS16500	COG0604	alcohol dehydrogenase
UA74_RS16500	COG3321	synthase
UA74_RS16610	COG1132	(ABC) transporter
UA74_RS16615	COG2375	cellular response to nickel ion
UA74_RS16615	COG1132	(ABC) transporter
UA74_RS16650	COG0601	transmembrane transport
UA74_RS16660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UA74_RS16685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UA74_RS16700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UA74_RS16710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UA74_RS16720	COG1349	DNA-binding transcription factor activity
UA74_RS16730	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
UA74_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS16775	COG2072	flavoprotein involved in K transport
UA74_RS16815	COG0477	Major facilitator Superfamily
UA74_RS16875	COG0300	oxidoreductase activity
UA74_RS16905	COG1309	transcriptional regulator
UA74_RS16925	COG3012	SEC-C Motif Domain Protein
UA74_RS16930	COG1131	(ABC) transporter
UA74_RS16975	COG1609	Transcriptional regulator
UA74_RS16980	COG1233	COG1233 Phytoene dehydrogenase and related
UA74_RS17005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UA74_RS17010	COG0318	PFAM AMP-dependent synthetase and ligase
UA74_RS17015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UA74_RS17030	COG3938	Belongs to the proline racemase family
UA74_RS17050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UA74_RS17055	COG1802	Transcriptional regulator
UA74_RS17075	COG0444	Belongs to the ABC transporter superfamily
UA74_RS17085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS17090	COG0747	negative chemotaxis
UA74_RS17100	COG3509	depolymerase
UA74_RS17100	COG3693	PFAM glycoside hydrolase, family 10
UA74_RS17130	COG1056	cytidyltransferase-related domain
UA74_RS17130	COG1051	belongs to the nudix hydrolase family
UA74_RS17140	COG0698	ribose 5-phosphate isomerase
UA74_RS17145	COG0477	Major facilitator Superfamily
UA74_RS17150	COG0137	argininosuccinate synthase activity
UA74_RS17165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UA74_RS17185	COG2423	ornithine cyclodeaminase activity
UA74_RS17190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UA74_RS17210	COG0010	Belongs to the arginase family
UA74_RS17225	COG1120	ATPase activity
UA74_RS17230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS17240	COG3336	cytochrome c oxidase
UA74_RS17270	COG3401	FG-GAP repeat protein
UA74_RS17295	COG3973	AAA domain
UA74_RS17300	COG1819	glycosyl
UA74_RS17325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UA74_RS17340	COG2197	response regulator
UA74_RS17345	COG3321	synthase
UA74_RS17345	COG0604	alcohol dehydrogenase
UA74_RS17365	COG2814	Major facilitator Superfamily
UA74_RS17415	COG2072	flavoprotein involved in K transport
UA74_RS17455	COG0477	Major facilitator Superfamily
UA74_RS17465	COG0583	DNA-binding transcription factor activity
UA74_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS17505	COG0326	Molecular chaperone. Has ATPase activity
UA74_RS17520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UA74_RS17530	COG2124	cytochrome p450
UA74_RS17555	COG0640	Transcriptional regulator
UA74_RS17580	COG0596	Alpha beta hydrolase
UA74_RS17585	COG0477	Major facilitator Superfamily
UA74_RS17605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UA74_RS17620	COG2124	cytochrome p450
UA74_RS17680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UA74_RS17700	COG1335	isochorismatase
UA74_RS17705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
UA74_RS17715	COG1032	radical SAM domain protein
UA74_RS17730	COG0489	protein tyrosine kinase activity
UA74_RS17735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UA74_RS17740	COG1518	maintenance of DNA repeat elements
UA74_RS17780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UA74_RS17785	COG1595	DNA-templated transcription, initiation
UA74_RS17845	COG1131	(ABC) transporter
UA74_RS17855	COG2197	response regulator
UA74_RS17865	COG1309	transcriptional regulator
UA74_RS17880	COG3507	Belongs to the glycosyl hydrolase 43 family
UA74_RS17910	COG1653	transport
UA74_RS17915	COG1609	Transcriptional regulator
UA74_RS17935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UA74_RS17940	COG0431	NADPH-dependent FMN reductase
UA74_RS17955	COG0789	Transcriptional regulator
UA74_RS17960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
UA74_RS17985	COG2391	methyltransferase activity
UA74_RS18025	COG2130	NADP-dependent
UA74_RS18030	COG1233	COG1233 Phytoene dehydrogenase and related
UA74_RS18055	COG0702	epimerase
UA74_RS18090	COG2267	carboxylic ester hydrolase activity
UA74_RS18100	COG1309	transcriptional regulator
UA74_RS18105	COG2409	Drug exporters of the RND superfamily
UA74_RS18110	COG1902	pentaerythritol trinitrate reductase activity
UA74_RS18115	COG0789	Transcriptional regulator
UA74_RS18125	COG0366	Alpha amylase catalytic
UA74_RS18180	COG4585	Histidine kinase
UA74_RS18205	COG0395	ABC-type sugar transport system, permease component
UA74_RS18210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UA74_RS18215	COG1609	Transcriptional regulator
UA74_RS18245	COG1755	Isoprenylcysteine carboxyl methyltransferase
UA74_RS18260	COG0523	cobalamin synthesis protein
UA74_RS18270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS18285	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS18290	COG1129	ABC transporter
UA74_RS18300	COG2186	Transcriptional regulator
UA74_RS18305	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS18340	COG1063	alcohol dehydrogenase
UA74_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS18370	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS18380	COG1129	ABC transporter
UA74_RS18385	COG1879	ABC-type sugar transport system periplasmic component
UA74_RS18390	COG3250	beta-galactosidase activity
UA74_RS18395	COG1349	DNA-binding transcription factor activity
UA74_RS18415	COG3903	Transcriptional regulator
UA74_RS18415	COG3629	intracellular signal transduction
UA74_RS18430	COG0667	Aldo Keto reductase
UA74_RS18480	COG0564	pseudouridine synthase activity
UA74_RS18495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS18630	COG2188	Transcriptional regulator
UA74_RS18650	COG4941	Belongs to the sigma-70 factor family
UA74_RS18685	COG2124	cytochrome p450
UA74_RS18745	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
UA74_RS18750	COG3959	Transketolase, thiamine diphosphate binding domain
UA74_RS18755	COG3958	Transketolase
UA74_RS18770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UA74_RS18820	COG1653	transport
UA74_RS18825	COG1175	transmembrane transport
UA74_RS18830	COG0395	ABC-type sugar transport system, permease component
UA74_RS18840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UA74_RS18845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UA74_RS18860	COG1414	Transcriptional regulator
UA74_RS18865	COG2182	Extracellular solute-binding protein
UA74_RS18870	COG1175	transmembrane transport
UA74_RS18880	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS18890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UA74_RS18900	COG0740	serine-type endopeptidase activity
UA74_RS18910	COG0583	DNA-binding transcription factor activity
UA74_RS18915	COG5006	permease, DMT superfamily
UA74_RS18920	COG1609	Transcriptional regulator
UA74_RS18955	COG0395	ABC-type sugar transport system, permease component
UA74_RS18960	COG1175	transmembrane transport
UA74_RS18990	COG3467	pyridoxamine 5'-phosphate
UA74_RS19020	COG0346	lactoylglutathione lyase activity
UA74_RS19025	COG0640	Transcriptional regulator
UA74_RS19035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UA74_RS19040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UA74_RS19040	COG0456	acetyltransferase
UA74_RS19085	COG1120	ATPase activity
UA74_RS19090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS19105	COG0653	protein targeting
UA74_RS19110	COG0702	epimerase
UA74_RS19115	COG0443	Heat shock 70 kDa protein
UA74_RS19200	COG1205	dead DEAH box helicase
UA74_RS19200	COG1111	helicase
UA74_RS19210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UA74_RS19225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UA74_RS19255	COG1863	multisubunit Na H antiporter MnhE subunit
UA74_RS19260	COG0651	ATP synthesis coupled electron transport
UA74_RS19265	COG1006	Multisubunit Na H antiporter MnhC subunit
UA74_RS19270	COG2111	Na H antiporter
UA74_RS19270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UA74_RS19285	COG1131	(ABC) transporter
UA74_RS19290	COG0569	domain protein
UA74_RS19295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UA74_RS19300	COG2205	protein histidine kinase activity
UA74_RS19305	COG0745	RESPONSE REGULATOR receiver
UA74_RS19315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UA74_RS19360	COG2409	Drug exporters of the RND superfamily
UA74_RS19425	COG0129	dihydroxy-acid dehydratase activity
UA74_RS19460	COG2076	Multidrug Resistance protein
UA74_RS19465	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS19470	COG1309	transcriptional regulator
UA74_RS19490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS19495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS19520	COG2261	transglycosylase associated protein
UA74_RS19535	COG0714	Associated with various cellular activities
UA74_RS19540	COG3552	Protein containing von Willebrand factor type A (VWA) domain
UA74_RS19565	COG0477	Major facilitator Superfamily
UA74_RS19575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UA74_RS19580	COG0798	PFAM Bile acid sodium symporter
UA74_RS19585	COG0640	Transcriptional regulator
UA74_RS19590	COG0492	ferredoxin-NADP+ reductase activity
UA74_RS19620	COG1063	alcohol dehydrogenase
UA74_RS19625	COG0395	ABC-type sugar transport system, permease component
UA74_RS19630	COG1175	transmembrane transport
UA74_RS19640	COG0800	Aldolase
UA74_RS19670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UA74_RS19675	COG4335	DNA alkylation repair
UA74_RS19705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UA74_RS19710	COG1120	ATPase activity
UA74_RS19715	COG0028	Belongs to the TPP enzyme family
UA74_RS19735	COG1032	radical SAM domain protein
UA74_RS19745	COG2124	cytochrome p450
UA74_RS19785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UA74_RS19795	COG0640	Transcriptional regulator
UA74_RS19800	COG1250	3-hydroxyacyl-CoA dehydrogenase
UA74_RS19890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS19910	COG1105	Belongs to the carbohydrate kinase PfkB family
UA74_RS19935	COG2814	Major facilitator Superfamily
UA74_RS19970	COG3831	ATPase activity
UA74_RS19980	COG3831	ATPase activity
UA74_RS19985	COG0714	Associated with various cellular activities
UA74_RS19990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
UA74_RS19995	COG3552	Protein containing von Willebrand factor type A (VWA) domain
UA74_RS20000	COG4715	Zinc finger, swim domain protein
UA74_RS20005	COG2197	response regulator
UA74_RS20025	COG2267	carboxylic ester hydrolase activity
UA74_RS20065	COG2186	Transcriptional regulator
UA74_RS20075	COG2376	Dihydroxyacetone kinase
UA74_RS20080	COG0698	ribose 5-phosphate isomerase
UA74_RS20085	COG0149	triose-phosphate isomerase activity
UA74_RS20090	COG1082	Xylose isomerase domain protein TIM barrel
UA74_RS20095	COG2084	Dehydrogenase
UA74_RS20110	COG2706	6-phosphogluconolactonase activity
UA74_RS20120	COG1921	L-seryl-tRNASec selenium transferase activity
UA74_RS20135	COG3842	ATPase activity
UA74_RS20175	COG1846	Transcriptional regulator
UA74_RS20180	COG0596	Alpha beta hydrolase
UA74_RS20225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS20230	COG0405	Gamma-glutamyltransferase
UA74_RS20260	COG1660	Displays ATPase and GTPase activities
UA74_RS20395	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS20400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS20405	COG4592	Periplasmic binding protein
UA74_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS20425	COG1309	transcriptional regulator
UA74_RS20445	COG0510	thiamine kinase activity
UA74_RS20450	COG3250	beta-galactosidase activity
UA74_RS20495	COG1278	Cold shock
UA74_RS20500	COG3226	Transcriptional regulator
UA74_RS20515	COG2515	1-aminocyclopropane-1-carboxylate deaminase
UA74_RS20530	COG2085	NADP oxidoreductase coenzyme F420-dependent
UA74_RS20540	COG0583	DNA-binding transcription factor activity
UA74_RS20545	COG2267	carboxylic ester hydrolase activity
UA74_RS20560	COG2368	4-hydroxyphenylacetate
UA74_RS20575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UA74_RS20580	COG3473	Maleate cis-trans isomerase
UA74_RS20590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UA74_RS20595	COG1404	Belongs to the peptidase S8 family
UA74_RS20620	COG2815	serine threonine protein kinase
UA74_RS20620	COG0515	serine threonine protein kinase
UA74_RS20650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UA74_RS20685	COG3940	Belongs to the glycosyl hydrolase 43 family
UA74_RS20700	COG1432	Conserved Protein
UA74_RS20705	COG1063	alcohol dehydrogenase
UA74_RS20710	COG0247	lactate metabolic process
UA74_RS20715	COG1139	Iron-sulfur cluster binding protein
UA74_RS20720	COG1556	Lactate utilization protein
UA74_RS20725	COG0494	nUDIX hydrolase
UA74_RS20740	COG0745	RESPONSE REGULATOR receiver
UA74_RS20745	COG2205	protein histidine kinase activity
UA74_RS20755	COG2755	lipolytic protein G-D-S-L family
UA74_RS20755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UA74_RS20790	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS20795	COG1129	ABC transporter
UA74_RS20870	COG0525	valine-tRNA ligase activity
UA74_RS20880	COG1136	(ABC) transporter
UA74_RS20880	COG0577	efflux transmembrane transporter activity
UA74_RS20900	COG0464	growth
UA74_RS20915	COG4946	Tricorn protease homolog
UA74_RS20915	COG0823	Involved in the tonB-independent uptake of proteins
UA74_RS20915	COG1506	peptidase
UA74_RS20930	COG2890	protein-(glutamine-N5) methyltransferase activity
UA74_RS20935	COG3629	intracellular signal transduction
UA74_RS20935	COG3903	Transcriptional regulator
UA74_RS21000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS21070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UA74_RS21080	COG0438	transferase activity, transferring glycosyl groups
UA74_RS21085	COG1940	carbohydrate kinase activity
UA74_RS21100	COG1082	Xylose isomerase domain protein TIM barrel
UA74_RS21105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UA74_RS21110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UA74_RS21115	COG0745	RESPONSE REGULATOR receiver
UA74_RS21120	COG4733	cellulase activity
UA74_RS21120	COG5297	Belongs to the glycosyl hydrolase family 6
UA74_RS21130	COG2723	6-phospho-beta-galactosidase activity
UA74_RS21135	COG0395	ABC-type sugar transport system, permease component
UA74_RS21170	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS21175	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
UA74_RS21190	COG2226	methyltransferase
UA74_RS21200	COG0254	rRNA binding
UA74_RS21225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UA74_RS21230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UA74_RS21235	COG0656	L-ascorbic acid biosynthetic process
UA74_RS21245	COG0438	transferase activity, transferring glycosyl groups
UA74_RS21250	COG1309	transcriptional regulator
UA74_RS21255	COG1131	(ABC) transporter
UA74_RS21275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UA74_RS21295	COG0739	heme binding
UA74_RS21320	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
UA74_RS21325	COG0473	3-isopropylmalate dehydrogenase activity
UA74_RS21330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UA74_RS21335	COG0586	Pfam SNARE associated Golgi protein
UA74_RS21340	COG0659	secondary active sulfate transmembrane transporter activity
UA74_RS21360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UA74_RS21365	COG0076	glutamate decarboxylase activity
UA74_RS21375	COG1946	Acyl-CoA thioesterase
UA74_RS21390	COG2234	aminopeptidase activity
UA74_RS21405	COG0067	glutamate synthase
UA74_RS21405	COG0069	glutamate synthase activity
UA74_RS21405	COG0070	glutamate synthase
UA74_RS21410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UA74_RS21415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS21420	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
UA74_RS21435	COG0022	dehydrogenase e1 component
UA74_RS21445	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
UA74_RS21445	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
UA74_RS21515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
UA74_RS21530	COG0702	epimerase
UA74_RS21550	COG2197	response regulator
UA74_RS21575	COG0494	nUDIX hydrolase
UA74_RS21580	COG0504	CTP synthase activity
UA74_RS21600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UA74_RS21615	COG0647	UMP catabolic process
UA74_RS21650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UA74_RS21655	COG2094	Belongs to the DNA glycosylase MPG family
UA74_RS21660	COG0165	Argininosuccinate lyase
UA74_RS21670	COG1438	arginine binding
UA74_RS21675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UA74_RS21685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UA74_RS21690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UA74_RS21695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UA74_RS21725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UA74_RS21725	COG0072	phenylalanine-tRNA ligase activity
UA74_RS21730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UA74_RS21740	COG3550	peptidyl-serine autophosphorylation
UA74_RS21745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UA74_RS21750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UA74_RS21755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UA74_RS21820	COG2356	endonuclease I
UA74_RS21855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UA74_RS21860	COG1929	Belongs to the glycerate kinase type-1 family
UA74_RS21875	COG2205	protein histidine kinase activity
UA74_RS21940	COG4221	oxidoreductase activity
UA74_RS21950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UA74_RS22000	COG0640	Transcriptional regulator
UA74_RS22035	COG0778	Nitroreductase
UA74_RS22055	COG1595	DNA-templated transcription, initiation
UA74_RS22145	COG0667	Aldo Keto reductase
UA74_RS22185	COG3226	Transcriptional regulator
UA74_RS22190	COG0738	Major facilitator superfamily
UA74_RS22205	COG0673	inositol 2-dehydrogenase activity
UA74_RS22225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS22230	COG0601	transmembrane transport
UA74_RS22235	COG0747	negative chemotaxis
UA74_RS22240	COG0673	inositol 2-dehydrogenase activity
UA74_RS22255	COG1609	Transcriptional regulator
UA74_RS22260	COG0246	Mannitol dehydrogenase
UA74_RS22265	COG2721	sulfolactate sulfo-lyase activity
UA74_RS22275	COG0363	glucosamine-6-phosphate deaminase activity
UA74_RS22280	COG2267	carboxylic ester hydrolase activity
UA74_RS22285	COG1309	transcriptional regulator
UA74_RS22305	COG1120	ATPase activity
UA74_RS22320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS22335	COG2357	RelA SpoT domain protein
UA74_RS22350	COG2186	Transcriptional regulator
UA74_RS22365	COG1175	transmembrane transport
UA74_RS22370	COG0395	ABC-type sugar transport system, permease component
UA74_RS22385	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS22400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UA74_RS22410	COG0183	Belongs to the thiolase family
UA74_RS22420	COG2271	Major facilitator Superfamily
UA74_RS22430	COG0596	Alpha beta hydrolase
UA74_RS22435	COG1309	transcriptional regulator
UA74_RS22455	COG0702	epimerase
UA74_RS22475	COG2197	response regulator
UA74_RS22480	COG4585	Histidine kinase
UA74_RS22490	COG2132	Multicopper oxidase
UA74_RS22505	COG2124	cytochrome p450
UA74_RS22510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UA74_RS22525	COG2315	Protein conserved in bacteria
UA74_RS22530	COG0542	response to heat
UA74_RS22555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UA74_RS22560	COG0747	negative chemotaxis
UA74_RS22570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS22575	COG0444	Belongs to the ABC transporter superfamily
UA74_RS22580	COG4608	Belongs to the ABC transporter superfamily
UA74_RS22600	COG1733	regulation of RNA biosynthetic process
UA74_RS22605	COG1414	Transcriptional regulator
UA74_RS22610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS22660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UA74_RS22705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UA74_RS22715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UA74_RS22720	COG0583	DNA-binding transcription factor activity
UA74_RS22725	COG0747	negative chemotaxis
UA74_RS22735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UA74_RS22760	COG0640	Transcriptional regulator
UA74_RS22770	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS22780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UA74_RS22795	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS22805	COG1414	Transcriptional regulator
UA74_RS22825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UA74_RS22845	COG0583	DNA-binding transcription factor activity
UA74_RS22850	COG2814	Major facilitator Superfamily
UA74_RS22860	COG0667	Aldo Keto reductase
UA74_RS22940	COG2814	Major facilitator Superfamily
UA74_RS22965	COG0477	Major facilitator Superfamily
UA74_RS22970	COG0477	Major facilitator Superfamily
UA74_RS22990	COG2390	Transcriptional regulator
UA74_RS22995	COG1063	alcohol dehydrogenase
UA74_RS23010	COG0395	ABC-type sugar transport system, permease component
UA74_RS23040	COG2205	protein histidine kinase activity
UA74_RS23045	COG0590	tRNA wobble adenosine to inosine editing
UA74_RS23045	COG0037	tRNA processing
UA74_RS23065	COG2124	cytochrome p450
UA74_RS23090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UA74_RS23135	COG3903	Transcriptional regulator
UA74_RS23135	COG3629	intracellular signal transduction
UA74_RS23165	COG1857	crispr-associated protein
UA74_RS23205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
UA74_RS23225	COG0477	Major facilitator Superfamily
UA74_RS23275	COG1857	crispr-associated protein
UA74_RS23305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UA74_RS23315	COG2183	response to ionizing radiation
UA74_RS23340	COG4257	antibiotic catabolic process
UA74_RS23375	COG4585	Histidine kinase
UA74_RS23380	COG2197	response regulator
UA74_RS23385	COG1271	oxidase subunit
UA74_RS23425	COG3401	FG-GAP repeat protein
UA74_RS23480	COG2375	cellular response to nickel ion
UA74_RS23580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
UA74_RS23590	COG0693	protein deglycase activity
UA74_RS23615	COG3473	Maleate cis-trans isomerase
UA74_RS23640	COG0248	Ppx GppA phosphatase
UA74_RS23645	COG3842	ATPase activity
UA74_RS23665	COG1609	Transcriptional regulator
UA74_RS23715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UA74_RS23725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UA74_RS23765	COG1793	dna ligase
UA74_RS23775	COG0124	histidyl-tRNA synthetase
UA74_RS23790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UA74_RS23800	COG3253	May function as heme-dependent peroxidase
UA74_RS23805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
UA74_RS23810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UA74_RS23820	COG2197	response regulator
UA74_RS23835	COG0183	Belongs to the thiolase family
UA74_RS23840	COG1024	Enoyl-CoA hydratase
UA74_RS23840	COG1250	3-hydroxyacyl-CoA dehydrogenase
UA74_RS23855	COG4948	Mandelate Racemase Muconate Lactonizing
UA74_RS23860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UA74_RS23870	COG0673	inositol 2-dehydrogenase activity
UA74_RS23875	COG1653	transport
UA74_RS23880	COG1175	transmembrane transport
UA74_RS23885	COG0395	ABC-type sugar transport system, permease component
UA74_RS23900	COG3866	Pectate lyase
UA74_RS23925	COG1653	transport
UA74_RS23930	COG1070	Carbohydrate kinase
UA74_RS23945	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS23945	COG3347	Dehydrogenase
UA74_RS23950	COG4952	isomerase
UA74_RS23960	COG1609	Transcriptional regulator
UA74_RS23970	COG0673	inositol 2-dehydrogenase activity
UA74_RS24015	COG5297	Belongs to the glycosyl hydrolase family 6
UA74_RS24020	COG2176	DNA-directed DNA polymerase activity
UA74_RS24040	COG0823	Involved in the tonB-independent uptake of proteins
UA74_RS24040	COG1506	peptidase
UA74_RS24050	COG2197	response regulator
UA74_RS24070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UA74_RS24075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UA74_RS24080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UA74_RS24090	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
UA74_RS24095	COG0167	dihydroorotate dehydrogenase activity
UA74_RS24120	COG0543	2 iron, 2 sulfur cluster binding
UA74_RS24125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UA74_RS24155	COG2132	Multicopper oxidase
UA74_RS24200	COG0583	DNA-binding transcription factor activity
UA74_RS24210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UA74_RS24215	COG1609	Transcriptional regulator
UA74_RS24255	COG1609	Transcriptional regulator
UA74_RS24260	COG1609	Transcriptional regulator
UA74_RS24280	COG1175	transmembrane transport
UA74_RS24285	COG0395	ABC-type sugar transport system, permease component
UA74_RS24320	COG0395	ABC-type sugar transport system, permease component
UA74_RS24325	COG4209	transmembrane transport
UA74_RS24330	COG0405	Gamma-glutamyltransferase
UA74_RS24360	COG2311	Membrane
UA74_RS24380	COG2197	response regulator
UA74_RS24385	COG4585	Histidine kinase
UA74_RS24395	COG1131	(ABC) transporter
UA74_RS24405	COG4977	sequence-specific DNA binding
UA74_RS24420	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS24430	COG0596	Alpha beta hydrolase
UA74_RS24450	COG4106	trans-aconitate 2-methyltransferase activity
UA74_RS24460	COG0358	DNA primase activity
UA74_RS24465	COG1595	DNA-templated transcription, initiation
UA74_RS24475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
UA74_RS24485	COG3340	Belongs to the peptidase S51 family
UA74_RS24490	COG0423	glycine-tRNA ligase activity
UA74_RS24525	COG0701	Predicted permease
UA74_RS24535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UA74_RS24560	COG1131	(ABC) transporter
UA74_RS24565	COG2188	Transcriptional regulator
UA74_RS24570	COG1381	Involved in DNA repair and RecF pathway recombination
UA74_RS24575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UA74_RS24595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UA74_RS24605	COG0537	adenosine 5'-monophosphoramidase activity
UA74_RS24615	COG0484	heat shock protein binding
UA74_RS24620	COG1420	regulation of RNA biosynthetic process
UA74_RS24630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UA74_RS24695	COG2732	(Barnase) inhibitor
UA74_RS24705	COG0604	alcohol dehydrogenase
UA74_RS24735	COG0443	Heat shock 70 kDa protein
UA74_RS24740	COG1201	RNA secondary structure unwinding
UA74_RS24795	COG0142	geranyltranstransferase activity
UA74_RS24815	COG2815	serine threonine protein kinase
UA74_RS24815	COG0515	serine threonine protein kinase
UA74_RS24825	COG2268	Band 7 protein
UA74_RS24845	COG0584	glycerophosphoryl diester phosphodiesterase
UA74_RS24885	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
UA74_RS24970	COG1940	carbohydrate kinase activity
UA74_RS24980	COG0003	Pfam Anion-transporting ATPase
UA74_RS25005	COG0438	transferase activity, transferring glycosyl groups
UA74_RS25015	COG0791	NLP P60 protein
UA74_RS25050	COG2010	Cytochrome c
UA74_RS25055	COG1845	cytochrome c oxidase, subunit III
UA74_RS25070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UA74_RS25080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UA74_RS25130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UA74_RS25155	COG0667	Aldo Keto reductase
UA74_RS25170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
UA74_RS25175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
UA74_RS25185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UA74_RS25190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
UA74_RS25200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UA74_RS25210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UA74_RS25215	COG0508	dehydrogenase complex catalyzes the overall conversion of
UA74_RS25225	COG0321	lipoyl(octanoyl) transferase activity
UA74_RS25240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UA74_RS25255	COG0174	glutamine synthetase
UA74_RS25275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
UA74_RS25280	COG0519	Catalyzes the synthesis of GMP from XMP
UA74_RS25280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UA74_RS25305	COG0174	glutamine synthetase
UA74_RS25315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UA74_RS25315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UA74_RS25320	COG2318	DinB family
UA74_RS25325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UA74_RS25335	COG0435	Glutathione S-transferase
UA74_RS25365	COG0791	NLP P60 protein
UA74_RS25365	COG3883	PFAM NLP P60 protein
UA74_RS25475	COG1064	alcohol dehydrogenase
UA74_RS25500	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
UA74_RS25515	COG2239	Acts as a magnesium transporter
UA74_RS25590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UA74_RS25595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UA74_RS25675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
UA74_RS25680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UA74_RS25715	COG1254	Belongs to the acylphosphatase family
UA74_RS25740	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
UA74_RS25745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
UA74_RS25750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
UA74_RS25765	COG0571	ribonuclease III activity
UA74_RS25770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UA74_RS25790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UA74_RS25795	COG0742	ribosomal rna small subunit methyltransferase
UA74_RS25815	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
UA74_RS25830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UA74_RS25885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UA74_RS25895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UA74_RS25905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UA74_RS25925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UA74_RS25950	COG1725	Transcriptional regulator
UA74_RS25965	COG1131	(ABC) transporter
UA74_RS25985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UA74_RS26000	COG0626	cystathionine gamma-synthase activity
UA74_RS26005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UA74_RS26015	COG1920	GTP binding
UA74_RS26025	COG0494	nUDIX hydrolase
UA74_RS26025	COG0406	alpha-ribazole phosphatase activity
UA74_RS26035	COG0066	3-isopropylmalate dehydratase activity
UA74_RS26040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UA74_RS26065	COG1011	Hydrolase
UA74_RS26070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UA74_RS26080	COG0179	Fumarylacetoacetate (FAA) hydrolase
UA74_RS26100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UA74_RS26105	COG0473	3-isopropylmalate dehydrogenase activity
UA74_RS26110	COG1404	Belongs to the peptidase S8 family
UA74_RS26125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UA74_RS26130	COG0440	acetolactate synthase activity
UA74_RS26145	COG0129	dihydroxy-acid dehydratase activity
UA74_RS26170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UA74_RS26170	COG0515	serine threonine protein kinase
UA74_RS26180	COG2259	Doxx family
UA74_RS26185	COG2259	Doxx family
UA74_RS26220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UA74_RS26235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UA74_RS26245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UA74_RS26285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UA74_RS26290	COG1253	flavin adenine dinucleotide binding
UA74_RS26310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
UA74_RS26345	COG0477	Major facilitator Superfamily
UA74_RS26360	COG1960	acyl-CoA dehydrogenase activity
UA74_RS26370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UA74_RS26425	COG3903	Transcriptional regulator
UA74_RS26425	COG3629	intracellular signal transduction
UA74_RS26430	COG0596	Alpha beta hydrolase
UA74_RS26435	COG2508	Transcriptional regulator
UA74_RS26435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UA74_RS26440	COG0686	Belongs to the AlaDH PNT family
UA74_RS26470	COG0567	Dehydrogenase, E1 component
UA74_RS26470	COG0508	dehydrogenase complex catalyzes the overall conversion of
UA74_RS26495	COG1228	amidohydrolase
UA74_RS26520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
UA74_RS26525	COG2986	histidine ammonia-lyase
UA74_RS26560	COG1174	glycine betaine transport
UA74_RS26565	COG1174	glycine betaine transport
UA74_RS26570	COG0517	IMP dehydrogenase activity
UA74_RS26570	COG1125	glycine betaine transport
UA74_RS26600	COG0406	alpha-ribazole phosphatase activity
UA74_RS26620	COG1597	lipid kinase activity
UA74_RS26635	COG5662	AntiSigma factor
UA74_RS26645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UA74_RS26655	COG2135	peptidase activity
UA74_RS26665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UA74_RS26690	COG1012	belongs to the aldehyde dehydrogenase family
UA74_RS26705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UA74_RS26710	COG1011	Hydrolase
UA74_RS26720	COG0653	protein targeting
UA74_RS26725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UA74_RS26740	COG5000	phosphorelay sensor kinase activity
UA74_RS26740	COG5002	protein histidine kinase activity
UA74_RS26745	COG0745	RESPONSE REGULATOR receiver
UA74_RS26770	COG0531	amino acid
UA74_RS26775	COG1482	cell wall glycoprotein biosynthetic process
UA74_RS26785	COG2835	tetraacyldisaccharide 4'-kinase activity
UA74_RS26810	COG1994	Peptidase M50
UA74_RS26815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UA74_RS26820	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
UA74_RS26820	COG0778	Nitroreductase
UA74_RS26845	COG2188	Transcriptional regulator
UA74_RS26850	COG0641	radical SAM
UA74_RS26860	COG0297	glycogen (starch) synthase activity
UA74_RS26865	COG0438	transferase activity, transferring glycosyl groups
UA74_RS26885	COG0438	transferase activity, transferring glycosyl groups
UA74_RS26900	COG1316	TRANSCRIPTIONal
UA74_RS26905	COG1316	TRANSCRIPTIONal
UA74_RS26925	COG1131	(ABC) transporter
UA74_RS26935	COG1879	ABC-type sugar transport system periplasmic component
UA74_RS26940	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS26945	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS26950	COG1129	ABC transporter
UA74_RS26965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UA74_RS26975	COG1690	Belongs to the RtcB family
UA74_RS27010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
UA74_RS27015	COG2205	protein histidine kinase activity
UA74_RS27020	COG0745	RESPONSE REGULATOR receiver
UA74_RS27025	COG0483	inositol monophosphate 1-phosphatase activity
UA74_RS27075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UA74_RS27090	COG3795	YCII-related domain
UA74_RS27095	COG2936	dipeptidyl-peptidase activity
UA74_RS27100	COG3311	Transcriptional regulator
UA74_RS27105	COG1840	ABC-type Fe3 transport system, periplasmic component
UA74_RS27115	COG3842	ATPase activity
UA74_RS27120	COG2828	Protein conserved in bacteria
UA74_RS27125	COG0583	DNA-binding transcription factor activity
UA74_RS27130	COG0424	maF-like protein
UA74_RS27140	COG1301	dicarboxylic acid transport
UA74_RS27145	COG4770	biotin carboxylase activity
UA74_RS27175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UA74_RS27180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UA74_RS27185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UA74_RS27220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
UA74_RS27220	COG1473	amidohydrolase
UA74_RS27270	COG0109	protoheme IX farnesyltransferase activity
UA74_RS27300	COG1172	Belongs to the binding-protein-dependent transport system permease family
UA74_RS27305	COG1129	ABC transporter
UA74_RS27335	COG4585	Histidine kinase
UA74_RS27340	COG1131	(ABC) transporter
UA74_RS27350	COG1940	carbohydrate kinase activity
UA74_RS27355	COG1070	Carbohydrate kinase
UA74_RS27360	COG3226	Transcriptional regulator
UA74_RS27390	COG0651	ATP synthesis coupled electron transport
UA74_RS27395	COG1006	Multisubunit Na H antiporter MnhC subunit
UA74_RS27405	COG2111	Na H antiporter
UA74_RS27405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UA74_RS27410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UA74_RS27410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UA74_RS27415	COG0515	serine threonine protein kinase
UA74_RS27425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UA74_RS27430	COG0667	Aldo Keto reductase
UA74_RS27440	COG3654	unkown
UA74_RS27475	COG0667	Aldo Keto reductase
UA74_RS27480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UA74_RS27485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UA74_RS27510	COG0494	nUDIX hydrolase
UA74_RS27585	COG1012	belongs to the aldehyde dehydrogenase family
UA74_RS27590	COG1012	belongs to the aldehyde dehydrogenase family
UA74_RS27640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
UA74_RS27660	COG1079	Belongs to the binding-protein-dependent transport system permease family
UA74_RS27670	COG3845	ABC transporter
UA74_RS27675	COG1744	ABC transporter substrate-binding protein PnrA-like
UA74_RS27680	COG2009	succinate dehydrogenase
UA74_RS27695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UA74_RS27700	COG1686	Belongs to the peptidase S11 family
UA74_RS27705	COG1295	ribonuclease BN
UA74_RS27725	COG0708	Exodeoxyribonuclease III
UA74_RS27770	COG0039	L-malate dehydrogenase activity
UA74_RS27785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UA74_RS27820	COG0587	DNA-directed DNA polymerase activity
UA74_RS27835	COG0138	bifunctional purine biosynthesis protein purh
UA74_RS27860	COG0045	succinate-CoA ligase (ADP-forming) activity
UA74_RS27870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UA74_RS27880	COG0739	heme binding
UA74_RS27885	COG4942	peptidase
UA74_RS27895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS27975	COG0515	serine threonine protein kinase
UA74_RS27980	COG0583	DNA-binding transcription factor activity
UA74_RS28015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UA74_RS28015	COG0519	Catalyzes the synthesis of GMP from XMP
UA74_RS28020	COG1012	belongs to the aldehyde dehydrogenase family
UA74_RS28055	COG0516	GMP reductase activity
UA74_RS28095	COG0459	protein refolding
UA74_RS28100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UA74_RS28105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UA74_RS28115	COG3540	Alkaline phosphatase
UA74_RS28120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UA74_RS28125	COG0456	acetyltransferase
UA74_RS28135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UA74_RS28140	COG1414	Transcriptional regulator
UA74_RS28150	COG0802	atpase or kinase
UA74_RS28160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UA74_RS28170	COG0736	holo-[acyl-carrier-protein] synthase activity
UA74_RS28210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UA74_RS28215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UA74_RS28220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UA74_RS28235	COG0443	Heat shock 70 kDa protein
UA74_RS28240	COG1674	ftsk spoiiie
UA74_RS28250	COG1404	Belongs to the peptidase S8 family
UA74_RS28305	COG3300	MHYT domain
UA74_RS28305	COG5001	Diguanylate cyclase
UA74_RS28320	COG4122	O-methyltransferase activity
UA74_RS28350	COG1674	ftsk spoiiie
UA74_RS28360	COG0456	acetyltransferase
UA74_RS28365	COG2130	NADP-dependent
UA74_RS28385	COG4152	abc transporter atp-binding protein
UA74_RS28390	COG1668	transmembrane transport
UA74_RS28395	COG0415	Belongs to the DNA photolyase family
UA74_RS28410	COG1228	amidohydrolase
UA74_RS28415	COG2017	converts alpha-aldose to the beta-anomer
UA74_RS28420	COG0531	amino acid
UA74_RS28425	COG0477	Major facilitator Superfamily
UA74_RS28430	COG0259	pyridoxamine-phosphate oxidase activity
UA74_RS28465	COG1132	(ABC) transporter
UA74_RS28495	COG2252	PERMEase
UA74_RS28540	COG1278	Cold shock
UA74_RS28550	COG0546	phosphoglycolate phosphatase activity
UA74_RS28575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UA74_RS28585	COG1652	LysM domain
UA74_RS28595	COG0315	cyclic pyranopterin monophosphate synthase activity
UA74_RS28630	COG2018	Roadblock/LC7 domain
UA74_RS28655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UA74_RS28660	COG1116	anion transmembrane transporter activity
UA74_RS28665	COG1061	Type III restriction enzyme res subunit
UA74_RS28690	COG3142	Participates in the control of copper homeostasis
UA74_RS28715	COG0459	protein refolding
UA74_RS28740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UA74_RS28745	COG0167	dihydroorotate dehydrogenase activity
UA74_RS28775	COG1136	(ABC) transporter
UA74_RS28795	COG2733	membrane
UA74_RS28875	COG1733	regulation of RNA biosynthetic process
UA74_RS28890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UA74_RS28900	COG0519	Catalyzes the synthesis of GMP from XMP
UA74_RS28920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UA74_RS28935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UA74_RS28940	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
UA74_RS28960	COG1215	transferase activity, transferring glycosyl groups
UA74_RS28980	COG1216	Glycosyl transferase, family 2
UA74_RS28995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UA74_RS29015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UA74_RS29050	COG1316	TRANSCRIPTIONal
UA74_RS29060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UA74_RS29065	COG1960	acyl-CoA dehydrogenase activity
UA74_RS29080	COG3844	kynureninase activity
UA74_RS29170	COG1674	ftsk spoiiie
UA74_RS29170	COG0531	amino acid
UA74_RS29255	COG0704	Plays a role in the regulation of phosphate uptake
UA74_RS29265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UA74_RS29270	COG0581	inorganic phosphate transmembrane transporter activity
UA74_RS29285	COG0456	acetyltransferase
UA74_RS29290	COG0745	RESPONSE REGULATOR receiver
UA74_RS29325	COG4044	May play a role in the intracellular transport of hydrophobic ligands
UA74_RS29390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UA74_RS29405	COG3387	PFAM Glycoside hydrolase 15-related
UA74_RS29425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UA74_RS29430	COG0047	phosphoribosylformylglycinamidine synthase activity
UA74_RS29435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UA74_RS29465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UA74_RS29475	COG1595	DNA-templated transcription, initiation
UA74_RS29480	COG0789	Transcriptional regulator
UA74_RS29505	COG1595	DNA-templated transcription, initiation
UA74_RS29515	COG1011	Hydrolase
UA74_RS29525	COG0436	Aminotransferase
UA74_RS29540	COG0025	NhaP-type Na H and K H
UA74_RS29545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UA74_RS29605	COG1309	transcriptional regulator
UA74_RS29610	COG2814	Major facilitator Superfamily
UA74_RS29625	COG4129	membrane
UA74_RS29665	COG1940	carbohydrate kinase activity
UA74_RS29680	COG0277	FAD linked oxidase domain protein
UA74_RS29690	COG2197	response regulator
UA74_RS29700	COG1136	(ABC) transporter
UA74_RS29715	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
UA74_RS29720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UA74_RS29725	COG0443	Heat shock 70 kDa protein
UA74_RS29770	COG1115	amino acid carrier protein
UA74_RS29775	COG0471	metal ion transport
UA74_RS29780	COG0542	response to heat
UA74_RS29790	COG4221	oxidoreductase activity
UA74_RS29800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UA74_RS29835	COG1704	LemA family
UA74_RS29840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UA74_RS29855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UA74_RS29865	COG0789	Transcriptional regulator
UA74_RS29870	COG0484	heat shock protein binding
UA74_RS29875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UA74_RS29880	COG0443	Heat shock 70 kDa protein
UA74_RS29890	COG2181	nitrate reductase activity
UA74_RS29890	COG0247	lactate metabolic process
UA74_RS29895	COG1120	ATPase activity
UA74_RS29900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UA74_RS29915	COG5398	heme oxygenase
UA74_RS29925	COG1028	Short-chain dehydrogenase reductase Sdr
UA74_RS29955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UA74_RS29965	COG0477	Major facilitator Superfamily
UA74_RS29980	COG1960	acyl-CoA dehydrogenase activity
UA74_RS30000	COG2375	cellular response to nickel ion
UA74_RS30000	COG1132	(ABC) transporter
UA74_RS30010	COG1309	transcriptional regulator
UA74_RS30020	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
UA74_RS30050	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
UA74_RS30060	COG1126	abc transporter atp-binding protein
UA74_RS30065	COG0765	amino acid transport
UA74_RS30070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UA74_RS30075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UA74_RS30090	COG0022	dehydrogenase e1 component
UA74_RS30095	COG0508	dehydrogenase complex catalyzes the overall conversion of
UA74_RS30105	COG4221	oxidoreductase activity
UA74_RS30125	COG3339	Conserved Protein
UA74_RS30160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
UA74_RS30165	COG0360	Binds together with S18 to 16S ribosomal RNA
UA74_RS30170	COG0629	single-stranded DNA binding
UA74_RS30175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UA74_RS30180	COG0359	binds to the 23S rRNA
UA74_RS30185	COG0305	Participates in initiation and elongation during chromosome replication
UA74_RS30210	COG2124	cytochrome p450
UA74_RS30215	COG0789	Transcriptional regulator
UA74_RS30225	COG0789	Transcriptional regulator
UA74_RS30235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UA74_RS30240	COG2814	Major facilitator Superfamily
UA74_RS30295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UA74_RS30300	COG1869	D-ribose catabolic process
UA74_RS30305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UA74_RS30315	COG1129	ABC transporter
UA74_RS30320	COG1609	Transcriptional regulator
UA74_RS30345	COG0495	leucyl-tRNA aminoacylation
UA74_RS30355	COG1678	Uncharacterized ACR, COG1678
UA74_RS30365	COG0617	tRNA 3'-terminal CCA addition
UA74_RS30385	COG0515	serine threonine protein kinase
UA74_RS30385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UA74_RS30390	COG1595	DNA-templated transcription, initiation
UA74_RS30410	COG3409	Peptidoglycan-binding domain 1 protein
UA74_RS30410	COG0860	N-Acetylmuramoyl-L-alanine amidase
UA74_RS30420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UA74_RS30430	COG1475	DNA binding
UA74_RS30435	COG1192	Involved in chromosome partitioning
UA74_RS30440	COG0357	Ribosomal RNA small subunit methyltransferase G
UA74_RS30460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UA74_RS30465	COG0594	ribonuclease P activity
UA74_RS30470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
UA74_RS30550	COG1196	nuclear chromosome segregation
UA74_RS30550	COG0741	lytic transglycosylase activity
UA74_RS30550	COG0739	heme binding
UA74_RS30600	COG0579	oxidoreductase
UA74_RS30670	COG0739	heme binding
UA74_RS30670	COG0741	lytic transglycosylase activity
UA74_RS30670	COG1196	nuclear chromosome segregation
UA74_RS30705	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UA74_RS30840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UA74_RS31050	COG2318	DinB family
UA74_RS31085	COG1620	l-lactate permease
UA74_RS31100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UA74_RS31105	COG4585	Histidine kinase
UA74_RS31130	COG4608	Belongs to the ABC transporter superfamily
UA74_RS31190	COG2340	Cysteine-rich secretory protein family
UA74_RS31195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UA74_RS31210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UA74_RS31245	COG0702	epimerase
UA74_RS31305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UA74_RS31310	COG1879	ABC-type sugar transport system periplasmic component
UA74_RS31315	COG1172	Belongs to the binding-protein-dependent transport system permease family