locus-tag	class	description
TL08_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TL08_RS00010	COG0592	DNA-directed DNA polymerase activity
TL08_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TL08_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TL08_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TL08_RS00030	COG0187	DNA topoisomerase II activity
TL08_RS00090	COG3764	Sortase (surface protein transpeptidase)
TL08_RS00110	COG2815	serine threonine protein kinase
TL08_RS00110	COG0515	serine threonine protein kinase
TL08_RS00115	COG0515	serine threonine protein kinase
TL08_RS00120	COG0768	penicillin binding
TL08_RS00135	COG1716	ATPase activity
TL08_RS00140	COG1716	ATPase activity
TL08_RS00155	COG0018	arginyl-trna synthetase
TL08_RS00180	COG1309	transcriptional regulator
TL08_RS00235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TL08_RS00250	COG1174	glycine betaine transport
TL08_RS00275	COG0667	Aldo Keto reductase
TL08_RS00300	COG0438	transferase activity, transferring glycosyl groups
TL08_RS00320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TL08_RS00330	COG1404	Belongs to the peptidase S8 family
TL08_RS00345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TL08_RS00355	COG0425	Belongs to the sulfur carrier protein TusA family
TL08_RS00355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TL08_RS00365	COG1595	DNA-templated transcription, initiation
TL08_RS00370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TL08_RS00380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TL08_RS00390	COG3279	Response regulator of the LytR AlgR family
TL08_RS00400	COG3275	phosphorelay sensor kinase activity
TL08_RS00420	COG0653	protein targeting
TL08_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS00485	COG1309	transcriptional regulator
TL08_RS00490	COG1528	Iron-storage protein
TL08_RS00495	COG2235	arginine
TL08_RS00550	COG1271	oxidase subunit
TL08_RS00555	COG1294	oxidase, subunit
TL08_RS00560	COG4988	ABC transporter
TL08_RS00590	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TL08_RS00620	COG0754	glutathionylspermidine amidase activity
TL08_RS00625	COG3766	membrane
TL08_RS00635	COG1396	sequence-specific DNA binding
TL08_RS00645	COG0561	phosphatase activity
TL08_RS00650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TL08_RS00695	COG1216	Glycosyl transferase, family 2
TL08_RS00700	COG1216	Glycosyl transferase, family 2
TL08_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS00730	COG0604	alcohol dehydrogenase
TL08_RS00730	COG3321	synthase
TL08_RS00735	COG2234	aminopeptidase activity
TL08_RS00750	COG1846	Transcriptional regulator
TL08_RS00765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TL08_RS00770	COG0412	Dienelactone hydrolase
TL08_RS00775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TL08_RS00800	COG0183	Belongs to the thiolase family
TL08_RS00810	COG0287	Prephenate dehydrogenase
TL08_RS00820	COG0590	tRNA wobble adenosine to inosine editing
TL08_RS00830	COG1595	DNA-templated transcription, initiation
TL08_RS00845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TL08_RS00865	COG1309	transcriptional regulator
TL08_RS00875	COG1349	DNA-binding transcription factor activity
TL08_RS00880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TL08_RS00890	COG0601	transmembrane transport
TL08_RS00895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS00900	COG0444	Belongs to the ABC transporter superfamily
TL08_RS00905	COG4608	Belongs to the ABC transporter superfamily
TL08_RS00910	COG0667	Aldo Keto reductase
TL08_RS00925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TL08_RS00930	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS00935	COG1914	H( )-stimulated, divalent metal cation uptake system
TL08_RS01010	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS01015	COG1129	ABC transporter
TL08_RS01040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TL08_RS01045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TL08_RS01055	COG0747	negative chemotaxis
TL08_RS01060	COG0601	transmembrane transport
TL08_RS01065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS01070	COG0444	Belongs to the ABC transporter superfamily
TL08_RS01075	COG4608	Belongs to the ABC transporter superfamily
TL08_RS01135	COG1764	response to oxidative stress
TL08_RS01165	COG1408	metallophosphoesterase
TL08_RS01175	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
TL08_RS01180	COG4499	WXG100 protein secretion system (Wss), protein YukC
TL08_RS01180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL08_RS01190	COG0003	Pfam Anion-transporting ATPase
TL08_RS01220	COG0673	inositol 2-dehydrogenase activity
TL08_RS01235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TL08_RS01280	COG0596	Alpha beta hydrolase
TL08_RS01290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TL08_RS01295	COG0730	response to heat
TL08_RS01325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TL08_RS01360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TL08_RS01365	COG1737	Transcriptional regulator
TL08_RS01390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL08_RS01395	COG3876	Protein conserved in bacteria
TL08_RS01400	COG1472	Belongs to the glycosyl hydrolase 3 family
TL08_RS01450	COG1111	helicase
TL08_RS01450	COG1205	dead DEAH box helicase
TL08_RS01455	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TL08_RS01465	COG1754	DNA topoisomerase type I activity
TL08_RS01465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TL08_RS01475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TL08_RS01480	COG0470	DNA polymerase III
TL08_RS01490	COG0582	viral genome integration into host DNA
TL08_RS01530	COG2816	NAD+ diphosphatase activity
TL08_RS01570	COG2267	carboxylic ester hydrolase activity
TL08_RS01590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TL08_RS01600	COG2027	D-alanyl-D-alanine carboxypeptidase
TL08_RS01610	COG0037	tRNA processing
TL08_RS01620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TL08_RS01625	COG0302	gtp cyclohydrolase
TL08_RS01630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TL08_RS01670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TL08_RS01675	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TL08_RS01680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TL08_RS01685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TL08_RS01710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TL08_RS01735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TL08_RS01745	COG1329	Transcriptional regulator
TL08_RS01750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TL08_RS01805	COG0215	cysteine-tRNA ligase activity
TL08_RS01820	COG2226	methyltransferase
TL08_RS01840	COG2311	Membrane
TL08_RS01855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_RS01860	COG1121	(ABC) transporter
TL08_RS01865	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL08_RS01880	COG3842	ATPase activity
TL08_RS01885	COG3833	ABC-type maltose transport systems, permease component
TL08_RS01890	COG1175	transmembrane transport
TL08_RS01905	COG1609	Transcriptional regulator
TL08_RS01915	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TL08_RS01930	COG0667	Aldo Keto reductase
TL08_RS01935	COG0456	acetyltransferase
TL08_RS01940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TL08_RS01945	COG1917	Cupin 2, conserved barrel domain protein
TL08_RS01950	COG5285	phytanoyl-CoA dioxygenase
TL08_RS01960	COG3629	intracellular signal transduction
TL08_RS01960	COG3903	Transcriptional regulator
TL08_RS01975	COG2186	Transcriptional regulator
TL08_RS01990	COG0242	peptide deformylase activity
TL08_RS01995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TL08_RS02000	COG0351	phosphomethylpyrimidine kinase
TL08_RS02020	COG2022	thiamine diphosphate biosynthetic process
TL08_RS02030	COG2022	thiamine diphosphate biosynthetic process
TL08_RS02030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TL08_RS02035	COG0352	thiamine-phosphate diphosphorylase activity
TL08_RS02070	COG2188	Transcriptional regulator
TL08_RS02080	COG1175	transmembrane transport
TL08_RS02085	COG0395	ABC-type sugar transport system, permease component
TL08_RS02090	COG1472	Belongs to the glycosyl hydrolase 3 family
TL08_RS02095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TL08_RS02110	COG2197	response regulator
TL08_RS02125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TL08_RS02150	COG0788	formyltetrahydrofolate deformylase activity
TL08_RS02155	COG1309	transcriptional regulator
TL08_RS02175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TL08_RS02185	COG4133	protoheme IX ABC transporter activity
TL08_RS02200	COG0604	alcohol dehydrogenase
TL08_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS02200	COG3321	synthase
TL08_RS02225	COG0477	Major facilitator Superfamily
TL08_RS02230	COG0438	transferase activity, transferring glycosyl groups
TL08_RS02240	COG0588	phosphoglycerate mutase activity
TL08_RS02245	COG5002	protein histidine kinase activity
TL08_RS02265	COG0506	proline dehydrogenase activity
TL08_RS02300	COG1960	acyl-CoA dehydrogenase activity
TL08_RS02325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TL08_RS02330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TL08_RS02345	COG0113	porphobilinogen synthase activity
TL08_RS02375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TL08_RS02380	COG0406	alpha-ribazole phosphatase activity
TL08_RS02385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TL08_RS02390	COG0515	serine threonine protein kinase
TL08_RS02390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TL08_RS02395	COG0785	Cytochrome C biogenesis protein
TL08_RS02405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TL08_RS02425	COG1522	sequence-specific DNA binding
TL08_RS02435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TL08_RS02460	COG1575	Belongs to the MenA family. Type 1 subfamily
TL08_RS02470	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TL08_RS02475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TL08_RS02490	COG1169	isochorismate synthase
TL08_RS02505	COG3396	Phenylacetate-CoA oxygenase
TL08_RS02510	COG3460	Phenylacetate-CoA oxygenase
TL08_RS02515	COG3396	Phenylacetate-CoA oxygenase
TL08_RS02520	COG2151	metal-sulfur cluster biosynthetic enzyme
TL08_RS02525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TL08_RS02540	COG2226	methyltransferase
TL08_RS02555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TL08_RS02560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TL08_RS02565	COG0649	NAD binding
TL08_RS02575	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TL08_RS02580	COG1034	ATP synthesis coupled electron transport
TL08_RS02585	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TL08_RS02590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TL08_RS02595	COG0839	Belongs to the complex I subunit 6 family
TL08_RS02600	COG0713	ATP synthesis coupled electron transport
TL08_RS02615	COG1007	ATP synthesis coupled electron transport
TL08_RS02620	COG0142	geranyltranstransferase activity
TL08_RS02635	COG1013	pyruvate-flavodoxin oxidoreductase activity
TL08_RS02640	COG0674	pyruvate-flavodoxin oxidoreductase activity
TL08_RS02640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TL08_RS02645	COG1522	sequence-specific DNA binding
TL08_RS02650	COG1834	amidinotransferase
TL08_RS02655	COG2205	protein histidine kinase activity
TL08_RS02660	COG0745	RESPONSE REGULATOR receiver
TL08_RS02675	COG1136	(ABC) transporter
TL08_RS02675	COG0577	efflux transmembrane transporter activity
TL08_RS02680	COG0577	efflux transmembrane transporter activity
TL08_RS02680	COG1136	(ABC) transporter
TL08_RS02695	COG0515	serine threonine protein kinase
TL08_RS02695	COG2815	serine threonine protein kinase
TL08_RS02725	COG0596	Alpha beta hydrolase
TL08_RS02735	COG0501	Belongs to the peptidase M48B family
TL08_RS02745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TL08_RS02775	COG1666	GTP binding
TL08_RS02795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TL08_RS02800	COG2030	dehydratase
TL08_RS02810	COG0436	Aminotransferase
TL08_RS02830	COG0081	regulation of translation
TL08_RS02840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TL08_RS02850	COG0085	RNA polymerase activity
TL08_RS02855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TL08_RS02875	COG1131	(ABC) transporter
TL08_RS02885	COG2197	response regulator
TL08_RS02900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TL08_RS02905	COG0049	tRNA binding
TL08_RS02910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TL08_RS02915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TL08_RS02920	COG0051	transcription antitermination factor activity, RNA binding
TL08_RS02925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TL08_RS02930	COG0088	Forms part of the polypeptide exit tunnel
TL08_RS02935	COG0089	rRNA binding
TL08_RS02940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TL08_RS02945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TL08_RS02950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TL08_RS02955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TL08_RS02960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TL08_RS02970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TL08_RS02975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TL08_RS02980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TL08_RS02985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TL08_RS02990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TL08_RS02995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TL08_RS03005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TL08_RS03010	COG1841	ribosomal large subunit assembly
TL08_RS03015	COG0200	Binds to the 23S rRNA
TL08_RS03025	COG0563	adenylate kinase activity
TL08_RS03045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TL08_RS03050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TL08_RS03055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TL08_RS03060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TL08_RS03065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TL08_RS03070	COG0202	RNA polymerase activity
TL08_RS03075	COG0203	ribosomal protein L17
TL08_RS03080	COG0101	tRNA pseudouridine synthase activity
TL08_RS03090	COG2197	response regulator
TL08_RS03100	COG3903	Transcriptional regulator
TL08_RS03100	COG3629	intracellular signal transduction
TL08_RS03140	COG2860	membrane
TL08_RS03145	COG0745	RESPONSE REGULATOR receiver
TL08_RS03150	COG2205	protein histidine kinase activity
TL08_RS03160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TL08_RS03165	COG0521	Mo-molybdopterin cofactor biosynthetic process
TL08_RS03165	COG0315	cyclic pyranopterin monophosphate synthase activity
TL08_RS03180	COG1970	mechanosensitive ion channel activity
TL08_RS03195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TL08_RS03200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TL08_RS03210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TL08_RS03290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL08_RS03295	COG0574	Belongs to the PEP-utilizing enzyme family
TL08_RS03295	COG3848	Pyruvate phosphate dikinase
TL08_RS03305	COG2205	protein histidine kinase activity
TL08_RS03310	COG0745	RESPONSE REGULATOR receiver
TL08_RS03345	COG0640	Transcriptional regulator
TL08_RS03355	COG4989	oxidoreductase activity
TL08_RS03380	COG0714	Associated with various cellular activities
TL08_RS03405	COG3850	Histidine kinase
TL08_RS03410	COG2197	response regulator
TL08_RS03445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL08_RS03450	COG0084	hydrolase, TatD family'
TL08_RS03455	COG1652	LysM domain
TL08_RS03460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TL08_RS03480	COG1309	transcriptional regulator
TL08_RS03535	COG1595	DNA-templated transcription, initiation
TL08_RS03550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TL08_RS03555	COG2011	ABC-type metal ion transport system permease component
TL08_RS03560	COG1464	Belongs to the NlpA lipoprotein family
TL08_RS03565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TL08_RS03580	COG0488	(ABC) transporter
TL08_RS03605	COG0193	aminoacyl-tRNA hydrolase activity
TL08_RS03615	COG1914	H( )-stimulated, divalent metal cation uptake system
TL08_RS03625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TL08_RS03645	COG1309	transcriptional regulator
TL08_RS03670	COG4946	Tricorn protease homolog
TL08_RS03670	COG0793	Belongs to the peptidase S41A family
TL08_RS03695	COG0148	phosphopyruvate hydratase activity
TL08_RS03745	COG1252	NADH dehydrogenase
TL08_RS03780	COG0183	Belongs to the thiolase family
TL08_RS03785	COG2755	lipolytic protein G-D-S-L family
TL08_RS03805	COG1414	Transcriptional regulator
TL08_RS03820	COG2182	Extracellular solute-binding protein
TL08_RS03825	COG1175	transmembrane transport
TL08_RS03830	COG0395	ABC-type sugar transport system, permease component
TL08_RS03845	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS03890	COG2130	NADP-dependent
TL08_RS03905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_RS03910	COG3386	PFAM SMP-30 Gluconolaconase
TL08_RS03920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TL08_RS03935	COG3708	Transcriptional regulator
TL08_RS03935	COG2207	Transcriptional regulator
TL08_RS03940	COG3185	4-Hydroxyphenylpyruvate dioxygenase
TL08_RS03955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TL08_RS03980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TL08_RS04010	COG1331	Highly conserved protein containing a thioredoxin domain
TL08_RS04035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TL08_RS04045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_RS04055	COG0584	glycerophosphoryl diester phosphodiesterase
TL08_RS04060	COG0114	fumarate hydratase activity
TL08_RS04065	COG0492	ferredoxin-NADP+ reductase activity
TL08_RS04100	COG1722	exodeoxyribonuclease VII activity
TL08_RS04110	COG1570	exodeoxyribonuclease VII activity
TL08_RS04120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TL08_RS04140	COG0420	3'-5' exonuclease activity
TL08_RS04145	COG0419	ATPase involved in DNA repair
TL08_RS04155	COG0012	GTP binding
TL08_RS04180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TL08_RS04190	COG1309	transcriptional regulator
TL08_RS04195	COG0778	Nitroreductase
TL08_RS04280	COG4585	Histidine kinase
TL08_RS04300	COG2154	pterin-4-alpha-carbinolamine dehydratase
TL08_RS04310	COG4149	molybdate abc transporter
TL08_RS04315	COG3842	ATPase activity
TL08_RS04325	COG1131	(ABC) transporter
TL08_RS04335	COG0745	RESPONSE REGULATOR receiver
TL08_RS04350	COG1217	gtp-binding protein TYPA
TL08_RS04355	COG0747	negative chemotaxis
TL08_RS04360	COG0747	negative chemotaxis
TL08_RS04370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS04380	COG4608	Belongs to the ABC transporter superfamily
TL08_RS04390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TL08_RS04410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TL08_RS04425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TL08_RS04445	COG0655	NAD(P)H dehydrogenase (quinone) activity
TL08_RS04450	COG1611	Belongs to the LOG family
TL08_RS04455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TL08_RS04530	COG1024	Enoyl-CoA hydratase
TL08_RS04545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TL08_RS04550	COG0583	DNA-binding transcription factor activity
TL08_RS04555	COG2814	Major facilitator Superfamily
TL08_RS04560	COG0297	glycogen (starch) synthase activity
TL08_RS04565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TL08_RS04570	COG4122	O-methyltransferase activity
TL08_RS04575	COG1595	DNA-templated transcription, initiation
TL08_RS04585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TL08_RS04590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TL08_RS04640	COG0598	Magnesium transport protein CorA
TL08_RS04655	COG0613	PHP domain protein
TL08_RS04680	COG0513	Belongs to the DEAD box helicase family
TL08_RS04700	COG2267	carboxylic ester hydrolase activity
TL08_RS04730	COG1587	Uroporphyrinogen-III synthase
TL08_RS04745	COG0210	DNA helicase
TL08_RS04750	COG0210	DNA helicase
TL08_RS04765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TL08_RS04795	COG0612	Peptidase, M16
TL08_RS04825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TL08_RS04845	COG3480	Lon protease (S16) C-terminal proteolytic domain
TL08_RS04855	COG1615	UPF0182 protein
TL08_RS04875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TL08_RS04880	COG2884	Cell division ATP-binding protein ftsE
TL08_RS04885	COG2177	Part of the ABC transporter FtsEX involved in
TL08_RS04890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TL08_RS04905	COG0778	Nitroreductase
TL08_RS04945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_RS05020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TL08_RS05040	COG0640	Transcriptional regulator
TL08_RS05045	COG0586	Pfam SNARE associated Golgi protein
TL08_RS05050	COG2197	response regulator
TL08_RS05055	COG4585	Histidine kinase
TL08_RS05065	COG0737	Belongs to the 5'-nucleotidase family
TL08_RS05070	COG1643	Atp-dependent helicase
TL08_RS05075	COG2814	Major facilitator Superfamily
TL08_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS05110	COG2814	Major facilitator Superfamily
TL08_RS05120	COG3903	Transcriptional regulator
TL08_RS05120	COG3629	intracellular signal transduction
TL08_RS05135	COG2197	response regulator
TL08_RS05155	COG1335	isochorismatase
TL08_RS05160	COG0583	DNA-binding transcription factor activity
TL08_RS05175	COG1253	flavin adenine dinucleotide binding
TL08_RS05180	COG1253	flavin adenine dinucleotide binding
TL08_RS05185	COG4221	oxidoreductase activity
TL08_RS05230	COG1131	(ABC) transporter
TL08_RS05260	COG0667	Aldo Keto reductase
TL08_RS05275	COG4221	oxidoreductase activity
TL08_RS05300	COG0583	DNA-binding transcription factor activity
TL08_RS05310	COG2130	NADP-dependent
TL08_RS05330	COG0477	Major facilitator Superfamily
TL08_RS05340	COG1064	alcohol dehydrogenase
TL08_RS05350	COG1063	alcohol dehydrogenase
TL08_RS05370	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS05400	COG1131	(ABC) transporter
TL08_RS05415	COG2197	response regulator
TL08_RS05435	COG0745	RESPONSE REGULATOR receiver
TL08_RS05440	COG2205	protein histidine kinase activity
TL08_RS05450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TL08_RS05450	COG2755	lipolytic protein G-D-S-L family
TL08_RS05455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TL08_RS05460	COG0583	DNA-binding transcription factor activity
TL08_RS05470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS05480	COG0583	DNA-binding transcription factor activity
TL08_RS05490	COG4941	Belongs to the sigma-70 factor family
TL08_RS05505	COG1122	ATPase activity
TL08_RS05550	COG1819	glycosyl
TL08_RS05560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TL08_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS05585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_RS05590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TL08_RS05595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TL08_RS05600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_RS05605	COG0778	Nitroreductase
TL08_RS05615	COG0596	Alpha beta hydrolase
TL08_RS05620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TL08_RS05625	COG0736	holo-[acyl-carrier-protein] synthase activity
TL08_RS05650	COG1131	(ABC) transporter
TL08_RS05655	COG0842	Transport permease protein
TL08_RS05655	COG1511	domain protein
TL08_RS05660	COG0842	Transport permease protein
TL08_RS05715	COG0596	Alpha beta hydrolase
TL08_RS05730	COG3831	ATPase activity
TL08_RS05735	COG0596	Alpha beta hydrolase
TL08_RS05770	COG2226	methyltransferase
TL08_RS05825	COG2226	methyltransferase
TL08_RS05860	COG2124	cytochrome p450
TL08_RS05870	COG1937	Protein conserved in bacteria
TL08_RS05875	COG2217	Heavy metal translocating P-type atpase
TL08_RS05905	COG0110	maltose O-acetyltransferase activity
TL08_RS05915	COG0477	Major facilitator Superfamily
TL08_RS05925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TL08_RS05925	COG2124	cytochrome p450
TL08_RS05940	COG1733	regulation of RNA biosynthetic process
TL08_RS05945	COG4335	DNA alkylation repair
TL08_RS05960	COG0006	proline dipeptidase activity
TL08_RS05970	COG0659	secondary active sulfate transmembrane transporter activity
TL08_RS05980	COG0789	Transcriptional regulator
TL08_RS05990	COG1309	transcriptional regulator
TL08_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS06070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_RS06085	COG1846	Transcriptional regulator
TL08_RS06105	COG3639	organic phosphonate transmembrane transporter activity
TL08_RS06110	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TL08_RS06115	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TL08_RS06125	COG2188	Transcriptional regulator
TL08_RS06130	COG1063	alcohol dehydrogenase
TL08_RS06160	COG1276	copper resistance
TL08_RS06160	COG2372	response to copper ion
TL08_RS06180	COG4221	oxidoreductase activity
TL08_RS06185	COG1309	transcriptional regulator
TL08_RS06250	COG0484	heat shock protein binding
TL08_RS06270	COG1136	(ABC) transporter
TL08_RS06275	COG0577	efflux transmembrane transporter activity
TL08_RS06335	COG0560	Phosphoserine phosphatase
TL08_RS06335	COG3830	Belongs to the UPF0237 family
TL08_RS06355	COG1335	isochorismatase
TL08_RS06360	COG1619	proteins homologs of microcin C7 resistance protein MccF
TL08_RS06365	COG1063	alcohol dehydrogenase
TL08_RS06375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TL08_RS06390	COG3191	aminopeptidase activity
TL08_RS06430	COG0598	Magnesium transport protein CorA
TL08_RS06435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TL08_RS06440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TL08_RS06455	COG0058	SHG alpha-glucan phosphorylase activity
TL08_RS06460	COG0739	heme binding
TL08_RS06505	COG1119	ATPase activity
TL08_RS06510	COG1024	Enoyl-CoA hydratase
TL08_RS06550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_RS06555	COG0488	(ABC) transporter
TL08_RS06580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TL08_RS06590	COG0482	sulfurtransferase activity
TL08_RS06605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_RS06615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_RS06630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_RS06680	COG4638	Rieske (2fe-2S)
TL08_RS06690	COG5297	Belongs to the glycosyl hydrolase family 6
TL08_RS06720	COG4585	Histidine kinase
TL08_RS06725	COG2197	response regulator
TL08_RS06730	COG2267	carboxylic ester hydrolase activity
TL08_RS06765	COG1082	Xylose isomerase domain protein TIM barrel
TL08_RS06790	COG1376	ErfK ybiS ycfS ynhG family protein
TL08_RS06800	COG0402	S-adenosylhomocysteine deaminase activity
TL08_RS06810	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS06820	COG0596	Alpha beta hydrolase
TL08_RS06825	COG1595	DNA-templated transcription, initiation
TL08_RS06845	COG1131	(ABC) transporter
TL08_RS06870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TL08_RS06885	COG0318	PFAM AMP-dependent synthetase and ligase
TL08_RS06940	COG1175	transmembrane transport
TL08_RS06950	COG2723	6-phospho-beta-galactosidase activity
TL08_RS06955	COG2318	DinB family
TL08_RS06965	COG2267	carboxylic ester hydrolase activity
TL08_RS06980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TL08_RS06990	COG2197	response regulator
TL08_RS07070	COG2814	Major facilitator Superfamily
TL08_RS07095	COG1917	Cupin 2, conserved barrel domain protein
TL08_RS07115	COG1309	transcriptional regulator
TL08_RS07130	COG0018	arginyl-trna synthetase
TL08_RS07135	COG0019	diaminopimelate decarboxylase activity
TL08_RS07140	COG0460	homoserine dehydrogenase
TL08_RS07145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TL08_RS07150	COG0083	homoserine kinase activity
TL08_RS07155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TL08_RS07155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TL08_RS07165	COG0254	rRNA binding
TL08_RS07170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TL08_RS07175	COG2890	protein-(glutamine-N5) methyltransferase activity
TL08_RS07185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TL08_RS07190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TL08_RS07200	COG0356	it plays a direct role in the translocation of protons across the membrane
TL08_RS07205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TL08_RS07210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TL08_RS07215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TL08_RS07220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TL08_RS07225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TL08_RS07255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TL08_RS07270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TL08_RS07280	COG0765	amino acid transport
TL08_RS07285	COG0765	amino acid transport
TL08_RS07290	COG1126	abc transporter atp-binding protein
TL08_RS07305	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TL08_RS07330	COG2376	Dihydroxyacetone kinase
TL08_RS07335	COG1461	Dihydroxyacetone kinase
TL08_RS07360	COG0346	lactoylglutathione lyase activity
TL08_RS07370	COG0183	Belongs to the thiolase family
TL08_RS07385	COG2409	Drug exporters of the RND superfamily
TL08_RS07390	COG1846	Transcriptional regulator
TL08_RS07400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_RS07400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_RS07425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TL08_RS07430	COG0366	Alpha amylase catalytic
TL08_RS07455	COG2608	mercury ion transmembrane transporter activity
TL08_RS07475	COG1472	Belongs to the glycosyl hydrolase 3 family
TL08_RS07480	COG1609	Transcriptional regulator
TL08_RS07495	COG4209	transmembrane transport
TL08_RS07500	COG0395	ABC-type sugar transport system, permease component
TL08_RS07515	COG0640	Transcriptional regulator
TL08_RS07530	COG2272	Belongs to the type-B carboxylesterase lipase family
TL08_RS07570	COG2367	Beta-lactamase
TL08_RS07575	COG3629	intracellular signal transduction
TL08_RS07615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS07640	COG2205	protein histidine kinase activity
TL08_RS07645	COG0745	RESPONSE REGULATOR receiver
TL08_RS07660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS07670	COG1741	Belongs to the pirin family
TL08_RS07695	COG2197	response regulator
TL08_RS07705	COG0596	Alpha beta hydrolase
TL08_RS07735	COG2902	Dehydrogenase
TL08_RS07750	COG0366	Alpha amylase catalytic
TL08_RS07760	COG0668	transmembrane transport
TL08_RS07790	COG1505	serine-type exopeptidase activity
TL08_RS07810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TL08_RS07820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TL08_RS07870	COG4552	Acetyltransferase involved in intracellular survival and related
TL08_RS07900	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TL08_RS07925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TL08_RS07935	COG0544	peptidyl-prolyl cis-trans isomerase activity
TL08_RS07940	COG0740	serine-type endopeptidase activity
TL08_RS07945	COG0740	serine-type endopeptidase activity
TL08_RS07950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TL08_RS07965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TL08_RS07985	COG0525	valine-tRNA ligase activity
TL08_RS07990	COG0285	dihydrofolate synthase activity
TL08_RS08000	COG0105	UTP biosynthetic process
TL08_RS08005	COG1131	(ABC) transporter
TL08_RS08015	COG0842	Transport permease protein
TL08_RS08025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TL08_RS08040	COG1530	ribonuclease E activity
TL08_RS08040	COG1530	ribonuclease E activity
TL08_RS08045	COG3842	ATPase activity
TL08_RS08065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TL08_RS08075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TL08_RS08080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TL08_RS08090	COG0514	ATP-dependent DNA helicase (RecQ)
TL08_RS08095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TL08_RS08110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TL08_RS08115	COG0799	negative regulation of ribosome biogenesis
TL08_RS08120	COG0406	alpha-ribazole phosphatase activity
TL08_RS08125	COG2755	lipolytic protein G-D-S-L family
TL08_RS08130	COG1307	EDD domain protein, DegV family
TL08_RS08135	COG1596	polysaccharide export
TL08_RS08135	COG1555	photosystem II stabilization
TL08_RS08155	COG0268	Binds directly to 16S ribosomal RNA
TL08_RS08170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TL08_RS08200	COG1490	D-aminoacyl-tRNA deacylase activity
TL08_RS08205	COG0318	PFAM AMP-dependent synthetase and ligase
TL08_RS08205	COG0204	Acyl-transferase
TL08_RS08220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TL08_RS08225	COG2313	pseudouridylate synthase activity
TL08_RS08255	COG4214	carbohydrate transport
TL08_RS08260	COG1940	carbohydrate kinase activity
TL08_RS08270	COG1940	carbohydrate kinase activity
TL08_RS08275	COG0483	inositol monophosphate 1-phosphatase activity
TL08_RS08295	COG0756	dUTP diphosphatase activity
TL08_RS08320	COG0569	domain protein
TL08_RS08330	COG0531	amino acid
TL08_RS08335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TL08_RS08340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TL08_RS08345	COG0745	RESPONSE REGULATOR receiver
TL08_RS08350	COG2205	protein histidine kinase activity
TL08_RS08355	COG1231	oxidoreductase activity
TL08_RS08365	COG0481	GTPase activity
TL08_RS08370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TL08_RS08375	COG2137	regulation of response to DNA damage stimulus
TL08_RS08390	COG0800	Aldolase
TL08_RS08410	COG0765	amino acid transport
TL08_RS08415	COG0765	amino acid transport
TL08_RS08420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL08_RS08425	COG1126	abc transporter atp-binding protein
TL08_RS08430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TL08_RS08440	COG1196	nuclear chromosome segregation
TL08_RS08450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TL08_RS08465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TL08_RS08475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TL08_RS08485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TL08_RS08490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TL08_RS08520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TL08_RS08525	COG3395	kinase activity
TL08_RS08545	COG1506	peptidase
TL08_RS08545	COG0823	Involved in the tonB-independent uptake of proteins
TL08_RS08555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TL08_RS08565	COG2897	thiosulfate sulfurtransferase activity
TL08_RS08575	COG0123	including yeast histone deacetylase and acetoin utilization protein
TL08_RS08580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TL08_RS08590	COG5002	protein histidine kinase activity
TL08_RS08595	COG0745	RESPONSE REGULATOR receiver
TL08_RS08610	COG3265	gluconokinase activity
TL08_RS08650	COG0228	four-way junction DNA binding
TL08_RS08660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TL08_RS08665	COG0336	Belongs to the RNA methyltransferase TrmD family
TL08_RS08670	COG0335	large ribosomal subunit rRNA binding
TL08_RS08675	COG0681	Belongs to the peptidase S26 family
TL08_RS08680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TL08_RS08700	COG0601	transmembrane transport
TL08_RS08705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS08710	COG0444	Belongs to the ABC transporter superfamily
TL08_RS08715	COG4172	Belongs to the ABC transporter superfamily
TL08_RS08725	COG1940	carbohydrate kinase activity
TL08_RS08730	COG0792	nuclease activity
TL08_RS08750	COG1191	sigma factor activity
TL08_RS08760	COG0052	Belongs to the universal ribosomal protein uS2 family
TL08_RS08765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TL08_RS08770	COG0528	UMP kinase activity
TL08_RS08775	COG0233	cytoplasmic translational termination
TL08_RS08785	COG2226	methyltransferase
TL08_RS08790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TL08_RS08805	COG3842	ATPase activity
TL08_RS08815	COG1176	ABC-type spermidine putrescine transport system, permease component I
TL08_RS08820	COG1177	transmembrane transport
TL08_RS08825	COG2261	transglycosylase associated protein
TL08_RS08830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TL08_RS08840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TL08_RS08845	COG0456	acetyltransferase
TL08_RS08865	COG1492	cobalamin metabolic process
TL08_RS08890	COG2186	Transcriptional regulator
TL08_RS08910	COG1881	PFAM PEBP family protein
TL08_RS08920	COG4585	Histidine kinase
TL08_RS08925	COG2197	response regulator
TL08_RS08945	COG3226	Transcriptional regulator
TL08_RS08950	COG2814	Major facilitator Superfamily
TL08_RS08975	COG2124	cytochrome p450
TL08_RS08985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TL08_RS08985	COG1648	precorrin-2 dehydrogenase activity
TL08_RS08990	COG0513	Belongs to the DEAD box helicase family
TL08_RS09000	COG3022	response to hydroperoxide
TL08_RS09010	COG0442	prolyl-tRNA aminoacylation
TL08_RS09020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS09050	COG0779	Required for maturation of 30S ribosomal subunits
TL08_RS09065	COG0481	GTPase activity
TL08_RS09065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TL08_RS09065	COG0481	GTPase activity
TL08_RS09065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TL08_RS09075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TL08_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS09085	COG3153	acetyltransferase
TL08_RS09115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TL08_RS09150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TL08_RS09150	COG2146	nitrite reductase [NAD(P)H] activity
TL08_RS09155	COG2223	nitrite transmembrane transporter activity
TL08_RS09160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TL08_RS09165	COG0243	molybdopterin cofactor binding
TL08_RS09170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TL08_RS09175	COG1185	polyribonucleotide nucleotidyltransferase activity
TL08_RS09180	COG0612	Peptidase, M16
TL08_RS09185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TL08_RS09220	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TL08_RS09225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_RS09230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TL08_RS09235	COG1674	ftsk spoiiie
TL08_RS09245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TL08_RS09255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TL08_RS09265	COG1546	Belongs to the CinA family
TL08_RS09265	COG1058	Belongs to the CinA family
TL08_RS09270	COG1396	sequence-specific DNA binding
TL08_RS09280	COG1842	Phage shock protein A
TL08_RS09290	COG2233	PERMEase
TL08_RS09295	COG1192	Involved in chromosome partitioning
TL08_RS09320	COG0714	Associated with various cellular activities
TL08_RS09325	COG2001	Belongs to the MraZ family
TL08_RS09330	COG0275	rRNA processing
TL08_RS09345	COG0768	penicillin binding
TL08_RS09360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TL08_RS09365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TL08_RS09375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TL08_RS09380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TL08_RS09385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TL08_RS09390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS09400	COG1984	allophanate hydrolase subunit 2
TL08_RS09410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TL08_RS09415	COG1070	Carbohydrate kinase
TL08_RS09430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TL08_RS09435	COG1799	cell septum assembly
TL08_RS09450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TL08_RS09495	COG2124	cytochrome p450
TL08_RS09500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TL08_RS09505	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TL08_RS09515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TL08_RS09535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TL08_RS09540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TL08_RS09570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TL08_RS09575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TL08_RS09580	COG2318	DinB family
TL08_RS09585	COG1252	NADH dehydrogenase
TL08_RS09590	COG1595	DNA-templated transcription, initiation
TL08_RS09595	COG0131	Imidazoleglycerol-phosphate dehydratase
TL08_RS09600	COG0789	Transcriptional regulator
TL08_RS09605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TL08_RS09615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TL08_RS09630	COG0107	imidazoleglycerol-phosphate synthase activity
TL08_RS09640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TL08_RS09645	COG1309	transcriptional regulator
TL08_RS09650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TL08_RS09665	COG0134	indole-3-glycerol-phosphate synthase activity
TL08_RS09670	COG0133	tryptophan synthase activity
TL08_RS09675	COG0159	tryptophan synthase activity
TL08_RS09685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TL08_RS09700	COG1160	GTP binding
TL08_RS09710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_RS09720	COG2188	Transcriptional regulator
TL08_RS09725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TL08_RS09730	COG1280	lysine exporter protein (LysE YggA)
TL08_RS09735	COG1522	sequence-specific DNA binding
TL08_RS09755	COG0142	geranyltranstransferase activity
TL08_RS09785	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS09790	COG0179	Fumarylacetoacetate (FAA) hydrolase
TL08_RS09815	COG4941	Belongs to the sigma-70 factor family
TL08_RS09830	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TL08_RS09835	COG0671	phosphoesterase, PA-phosphatase related
TL08_RS09845	COG0741	lytic transglycosylase activity
TL08_RS09845	COG1196	nuclear chromosome segregation
TL08_RS09845	COG0739	heme binding
TL08_RS09855	COG1522	sequence-specific DNA binding
TL08_RS09885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TL08_RS09915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_RS09980	COG0514	ATP-dependent DNA helicase (RecQ)
TL08_RS09985	COG1764	response to oxidative stress
TL08_RS10100	COG2050	protein possibly involved in aromatic compounds catabolism
TL08_RS10130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_RS10135	COG0539	negative regulation of cytoplasmic translation
TL08_RS10140	COG2755	lipolytic protein G-D-S-L family
TL08_RS10140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TL08_RS10145	COG2755	lipolytic protein G-D-S-L family
TL08_RS10145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TL08_RS10150	COG0237	dephospho-CoA kinase activity
TL08_RS10150	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TL08_RS10190	COG1506	peptidase
TL08_RS10190	COG4946	Tricorn protease homolog
TL08_RS10190	COG0823	Involved in the tonB-independent uptake of proteins
TL08_RS10220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TL08_RS10230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TL08_RS10235	COG1560	Kdo2-lipid A biosynthetic process
TL08_RS10240	COG0438	transferase activity, transferring glycosyl groups
TL08_RS10245	COG1051	belongs to the nudix hydrolase family
TL08_RS10260	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TL08_RS10265	COG1396	sequence-specific DNA binding
TL08_RS10280	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TL08_RS10285	COG0217	transcriptional regulatory protein
TL08_RS10300	COG3903	Transcriptional regulator
TL08_RS10300	COG3629	intracellular signal transduction
TL08_RS10305	COG3104	oligopeptide transport
TL08_RS10320	COG2084	Dehydrogenase
TL08_RS10330	COG0475	glutathione-regulated potassium exporter activity
TL08_RS10350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_RS10355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_RS10360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_RS10395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TL08_RS10400	COG0632	four-way junction helicase activity
TL08_RS10405	COG2255	four-way junction helicase activity
TL08_RS10415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TL08_RS10420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TL08_RS10470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TL08_RS10475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TL08_RS10490	COG1404	Belongs to the peptidase S8 family
TL08_RS10490	COG4412	M6 family metalloprotease domain protein
TL08_RS10495	COG1404	Belongs to the peptidase S8 family
TL08_RS10495	COG4412	M6 family metalloprotease domain protein
TL08_RS10505	COG3226	Transcriptional regulator
TL08_RS10525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TL08_RS10530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TL08_RS10530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TL08_RS10535	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL08_RS10540	COG1121	(ABC) transporter
TL08_RS10545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_RS10550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_RS10555	COG2132	Multicopper oxidase
TL08_RS10560	COG1309	transcriptional regulator
TL08_RS10575	COG1607	acyl-coa hydrolase
TL08_RS10595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TL08_RS10635	COG1716	ATPase activity
TL08_RS10655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TL08_RS10655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TL08_RS10660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TL08_RS10685	COG1309	transcriptional regulator
TL08_RS10690	COG3572	ergothioneine biosynthetic process
TL08_RS10695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TL08_RS10700	COG0121	glutamine amidotransferase
TL08_RS10705	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TL08_RS10725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TL08_RS10740	COG0791	NLP P60 protein
TL08_RS10740	COG3883	PFAM NLP P60 protein
TL08_RS10750	COG0583	DNA-binding transcription factor activity
TL08_RS10755	COG0697	spore germination
TL08_RS10765	COG0714	Associated with various cellular activities
TL08_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS10785	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TL08_RS10790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TL08_RS10825	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS10860	COG3473	Maleate cis-trans isomerase
TL08_RS10870	COG2186	Transcriptional regulator
TL08_RS10880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TL08_RS10890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL08_RS10915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TL08_RS10920	COG0183	Belongs to the thiolase family
TL08_RS10925	COG1253	flavin adenine dinucleotide binding
TL08_RS10940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TL08_RS10945	COG0438	transferase activity, transferring glycosyl groups
TL08_RS10990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TL08_RS10995	COG0542	response to heat
TL08_RS11055	COG2186	Transcriptional regulator
TL08_RS11060	COG3401	FG-GAP repeat protein
TL08_RS11080	COG3618	amidohydrolase
TL08_RS11120	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_RS11125	COG0022	dehydrogenase e1 component
TL08_RS11130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TL08_RS11160	COG1643	Atp-dependent helicase
TL08_RS11200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TL08_RS11210	COG0662	Cupin 2, conserved barrel domain protein
TL08_RS11255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TL08_RS11275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TL08_RS11285	COG1263	PTS System
TL08_RS11290	COG2188	Transcriptional regulator
TL08_RS11295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL08_RS11295	COG1263	PTS System
TL08_RS11300	COG2190	(PTS) system
TL08_RS11310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TL08_RS11315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TL08_RS11325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TL08_RS11330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TL08_RS11355	COG0006	proline dipeptidase activity
TL08_RS11360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TL08_RS11365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TL08_RS11380	COG0540	Belongs to the ATCase OTCase family
TL08_RS11395	COG0505	Belongs to the CarA family
TL08_RS11405	COG0284	orotidine-5'-phosphate decarboxylase activity
TL08_RS11415	COG0194	GDP metabolic process
TL08_RS11420	COG1758	RNA polymerase activity
TL08_RS11430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TL08_RS11450	COG2226	methyltransferase
TL08_RS11465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TL08_RS11470	COG0242	peptide deformylase activity
TL08_RS11485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TL08_RS11485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TL08_RS11490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TL08_RS11505	COG0322	excinuclease ABC activity
TL08_RS11510	COG1660	Displays ATPase and GTPase activities
TL08_RS11520	COG1481	regulation of sporulation
TL08_RS11525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TL08_RS11530	COG0126	phosphoglycerate kinase activity
TL08_RS11535	COG0149	triose-phosphate isomerase activity
TL08_RS11540	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TL08_RS11550	COG1595	DNA-templated transcription, initiation
TL08_RS11555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TL08_RS11575	COG0363	glucosamine-6-phosphate deaminase activity
TL08_RS11590	COG0166	Belongs to the GPI family
TL08_RS11595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TL08_RS11605	COG0109	protoheme IX farnesyltransferase activity
TL08_RS11650	COG1131	(ABC) transporter
TL08_RS11655	COG2197	response regulator
TL08_RS11660	COG4585	Histidine kinase
TL08_RS11675	COG1510	regulation of RNA biosynthetic process
TL08_RS11690	COG1131	(ABC) transporter
TL08_RS11720	COG0396	ATPase activity
TL08_RS11730	COG0822	iron-sulfur transferase activity
TL08_RS11735	COG2151	metal-sulfur cluster biosynthetic enzyme
TL08_RS11755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TL08_RS11775	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TL08_RS11790	COG0488	(ABC) transporter
TL08_RS11795	COG1024	Enoyl-CoA hydratase
TL08_RS11800	COG0702	epimerase
TL08_RS11805	COG1733	regulation of RNA biosynthetic process
TL08_RS11830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TL08_RS11830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TL08_RS11850	COG0142	geranyltranstransferase activity
TL08_RS11855	COG2264	protein methyltransferase activity
TL08_RS11860	COG0140	phosphoribosyl-ATP diphosphatase activity
TL08_RS11865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TL08_RS11870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TL08_RS11900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TL08_RS11910	COG0517	IMP dehydrogenase activity
TL08_RS11910	COG1994	Peptidase M50
TL08_RS11935	COG1222	aaa ATPase
TL08_RS11960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_RS11965	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_RS11980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_RS11990	COG2378	regulation of single-species biofilm formation
TL08_RS12015	COG4552	Acetyltransferase involved in intracellular survival and related
TL08_RS12050	COG1136	(ABC) transporter
TL08_RS12060	COG3030	protein affecting phage T7 exclusion by the F plasmid
TL08_RS12065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TL08_RS12080	COG0745	RESPONSE REGULATOR receiver
TL08_RS12130	COG3845	ABC transporter
TL08_RS12175	COG0515	serine threonine protein kinase
TL08_RS12175	COG2815	serine threonine protein kinase
TL08_RS12185	COG1793	dna ligase
TL08_RS12185	COG3285	dna ligase
TL08_RS12210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TL08_RS12220	COG0385	Bile acid
TL08_RS12230	COG3903	Transcriptional regulator
TL08_RS12230	COG3629	intracellular signal transduction
TL08_RS12235	COG4607	ABC-type enterochelin transport system periplasmic component
TL08_RS12240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS12245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS12250	COG1120	ATPase activity
TL08_RS12255	COG1132	(ABC) transporter
TL08_RS12260	COG1132	(ABC) transporter
TL08_RS12300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TL08_RS12305	COG1309	transcriptional regulator
TL08_RS12325	COG1879	ABC-type sugar transport system periplasmic component
TL08_RS12330	COG1129	ABC transporter
TL08_RS12335	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS12340	COG1063	alcohol dehydrogenase
TL08_RS12355	COG2186	Transcriptional regulator
TL08_RS12360	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS12365	COG0800	Aldolase
TL08_RS12370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TL08_RS12395	COG2267	carboxylic ester hydrolase activity
TL08_RS12400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_RS12420	COG2814	Major facilitator Superfamily
TL08_RS12435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TL08_RS12440	COG1960	acyl-CoA dehydrogenase activity
TL08_RS12450	COG4221	oxidoreductase activity
TL08_RS12470	COG0559	Belongs to the binding-protein-dependent transport system permease family
TL08_RS12485	COG1960	acyl-CoA dehydrogenase activity
TL08_RS12490	COG0318	PFAM AMP-dependent synthetase and ligase
TL08_RS12495	COG0604	alcohol dehydrogenase
TL08_RS12520	COG0183	Belongs to the thiolase family
TL08_RS12525	COG1309	transcriptional regulator
TL08_RS12545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TL08_RS12550	COG1116	anion transmembrane transporter activity
TL08_RS12555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_RS12570	COG1733	regulation of RNA biosynthetic process
TL08_RS12580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_RS12590	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TL08_RS12595	COG0235	Class ii aldolase
TL08_RS12600	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TL08_RS12605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TL08_RS12615	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TL08_RS12620	COG1079	Belongs to the binding-protein-dependent transport system permease family
TL08_RS12625	COG1079	Belongs to the binding-protein-dependent transport system permease family
TL08_RS12630	COG3845	ABC transporter
TL08_RS12655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS12665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS12670	COG0601	transmembrane transport
TL08_RS12675	COG0747	negative chemotaxis
TL08_RS12690	COG0431	NADPH-dependent FMN reductase
TL08_RS12695	COG1309	transcriptional regulator
TL08_RS12700	COG1132	(ABC) transporter
TL08_RS12720	COG2018	Roadblock/LC7 domain
TL08_RS12775	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS12785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TL08_RS12800	COG0477	Major facilitator Superfamily
TL08_RS12805	COG0028	Belongs to the TPP enzyme family
TL08_RS12810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TL08_RS12815	COG2188	Transcriptional regulator
TL08_RS12825	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS12895	COG0673	inositol 2-dehydrogenase activity
TL08_RS12900	COG1116	anion transmembrane transporter activity
TL08_RS12910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_RS12940	COG0477	Major facilitator Superfamily
TL08_RS12960	COG0747	negative chemotaxis
TL08_RS12965	COG0601	transmembrane transport
TL08_RS12970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS12995	COG1278	Cold shock
TL08_RS13015	COG1619	proteins homologs of microcin C7 resistance protein MccF
TL08_RS13060	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TL08_RS13085	COG0215	cysteine-tRNA ligase activity
TL08_RS13095	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TL08_RS13105	COG1410	methionine synthase
TL08_RS13105	COG0646	methionine synthase
TL08_RS13110	COG0546	phosphoglycolate phosphatase activity
TL08_RS13115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS13120	COG0372	Belongs to the citrate synthase family
TL08_RS13125	COG0372	Belongs to the citrate synthase family
TL08_RS13130	COG1515	deoxyribonuclease V activity
TL08_RS13135	COG0242	peptide deformylase activity
TL08_RS13145	COG0477	Major facilitator Superfamily
TL08_RS13150	COG1132	(ABC) transporter
TL08_RS13165	COG1653	transport
TL08_RS13180	COG0235	Class ii aldolase
TL08_RS13185	COG3395	kinase activity
TL08_RS13200	COG1349	DNA-binding transcription factor activity
TL08_RS13225	COG0659	secondary active sulfate transmembrane transporter activity
TL08_RS13250	COG2814	Major facilitator Superfamily
TL08_RS13265	COG0076	glutamate decarboxylase activity
TL08_RS13290	COG0277	FAD linked oxidase domain protein
TL08_RS13310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_RS13325	COG1755	Isoprenylcysteine carboxyl methyltransferase
TL08_RS13350	COG0395	ABC-type sugar transport system, permease component
TL08_RS13355	COG1175	transmembrane transport
TL08_RS13400	COG2267	carboxylic ester hydrolase activity
TL08_RS13455	COG2130	NADP-dependent
TL08_RS13460	COG2375	cellular response to nickel ion
TL08_RS13475	COG2391	methyltransferase activity
TL08_RS13495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TL08_RS13500	COG2011	ABC-type metal ion transport system permease component
TL08_RS13505	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TL08_RS13520	COG0431	NADPH-dependent FMN reductase
TL08_RS13525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS13555	COG1653	transport
TL08_RS13560	COG1175	transmembrane transport
TL08_RS13585	COG3507	Belongs to the glycosyl hydrolase 43 family
TL08_RS13595	COG0009	L-threonylcarbamoyladenylate synthase
TL08_RS13600	COG1120	ATPase activity
TL08_RS13605	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS13610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS13620	COG2977	Belongs to the P-Pant transferase superfamily
TL08_RS13630	COG2027	D-alanyl-D-alanine carboxypeptidase
TL08_RS13635	COG0488	(ABC) transporter
TL08_RS13640	COG1063	alcohol dehydrogenase
TL08_RS13650	COG0400	carboxylic ester hydrolase activity
TL08_RS13655	COG0346	lactoylglutathione lyase activity
TL08_RS13660	COG1846	Transcriptional regulator
TL08_RS13665	COG1649	PFAM Uncharacterised BCR, COG1649
TL08_RS13680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TL08_RS13730	COG0667	Aldo Keto reductase
TL08_RS13740	COG2226	methyltransferase
TL08_RS13745	COG0488	(ABC) transporter
TL08_RS13750	COG1739	Uncharacterized protein family UPF0029
TL08_RS13800	COG0463	Glycosyl transferase, family 2
TL08_RS13810	COG1435	thymidine kinase activity
TL08_RS13830	COG3300	MHYT domain
TL08_RS13830	COG5001	Diguanylate cyclase
TL08_RS13880	COG1132	(ABC) transporter
TL08_RS13905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TL08_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS13925	COG0789	Transcriptional regulator
TL08_RS13945	COG1846	Transcriptional regulator
TL08_RS13970	COG0702	epimerase
TL08_RS13975	COG1733	regulation of RNA biosynthetic process
TL08_RS13990	COG1309	transcriptional regulator
TL08_RS14000	COG2267	carboxylic ester hydrolase activity
TL08_RS14005	COG1357	PFAM Pentapeptide repeats (8 copies)
TL08_RS14010	COG1309	transcriptional regulator
TL08_RS14035	COG1309	transcriptional regulator
TL08_RS14050	COG0739	heme binding
TL08_RS14065	COG0154	amidase activity
TL08_RS14070	COG1309	transcriptional regulator
TL08_RS14080	COG0604	alcohol dehydrogenase
TL08_RS14095	COG2890	protein-(glutamine-N5) methyltransferase activity
TL08_RS14130	COG2249	NAD(P)H dehydrogenase (quinone) activity
TL08_RS14145	COG1846	Transcriptional regulator
TL08_RS14150	COG1968	undecaprenyl-diphosphatase activity
TL08_RS14155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS14235	COG1201	RNA secondary structure unwinding
TL08_RS14290	COG1169	isochorismate synthase
TL08_RS14300	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
TL08_RS14320	COG2226	methyltransferase
TL08_RS14320	COG3433	isochorismatase activity
TL08_RS14320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_RS14330	COG1021	2,3-dihydroxybenzoate-AMP ligase
TL08_RS14365	COG2375	cellular response to nickel ion
TL08_RS14365	COG1132	(ABC) transporter
TL08_RS14370	COG1132	(ABC) transporter
TL08_RS14405	COG2197	response regulator
TL08_RS14410	COG1733	regulation of RNA biosynthetic process
TL08_RS14455	COG0604	alcohol dehydrogenase
TL08_RS14455	COG3321	synthase
TL08_RS14475	COG0604	alcohol dehydrogenase
TL08_RS14490	COG2226	methyltransferase
TL08_RS14500	COG0604	alcohol dehydrogenase
TL08_RS14500	COG3321	synthase
TL08_RS14500	COG0604	alcohol dehydrogenase
TL08_RS14500	COG3321	synthase
TL08_RS14505	COG3321	synthase
TL08_RS14505	COG0604	alcohol dehydrogenase
TL08_RS14535	COG3012	SEC-C Motif Domain Protein
TL08_RS14560	COG1609	Transcriptional regulator
TL08_RS14575	COG0300	oxidoreductase activity
TL08_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS14595	COG1309	transcriptional regulator
TL08_RS14600	COG3938	Belongs to the proline racemase family
TL08_RS14620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TL08_RS14625	COG1802	Transcriptional regulator
TL08_RS14645	COG0444	Belongs to the ABC transporter superfamily
TL08_RS14650	COG0601	transmembrane transport
TL08_RS14655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS14660	COG0747	negative chemotaxis
TL08_RS14685	COG1051	belongs to the nudix hydrolase family
TL08_RS14685	COG1056	cytidyltransferase-related domain
TL08_RS14690	COG1056	cytidyltransferase-related domain
TL08_RS14690	COG1051	belongs to the nudix hydrolase family
TL08_RS14735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_RS14745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TL08_RS14755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TL08_RS14760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TL08_RS14775	COG1309	transcriptional regulator
TL08_RS14780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TL08_RS14785	COG3401	FG-GAP repeat protein
TL08_RS14800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TL08_RS14805	COG3181	Tripartite tricarboxylate transporter family receptor
TL08_RS14820	COG0583	DNA-binding transcription factor activity
TL08_RS14835	COG0326	Molecular chaperone. Has ATPase activity
TL08_RS14840	COG0300	oxidoreductase activity
TL08_RS14865	COG1609	Transcriptional regulator
TL08_RS14880	COG0395	ABC-type sugar transport system, permease component
TL08_RS14890	COG2272	Belongs to the type-B carboxylesterase lipase family
TL08_RS14900	COG2197	response regulator
TL08_RS14910	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TL08_RS14915	COG3903	Transcriptional regulator
TL08_RS14915	COG3629	intracellular signal transduction
TL08_RS14920	COG0596	Alpha beta hydrolase
TL08_RS14945	COG0346	lactoylglutathione lyase activity
TL08_RS14965	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS14985	COG1032	radical SAM domain protein
TL08_RS15005	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS15010	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS15015	COG1129	ABC transporter
TL08_RS15020	COG1879	ABC-type sugar transport system periplasmic component
TL08_RS15030	COG3250	beta-galactosidase activity
TL08_RS15035	COG1349	DNA-binding transcription factor activity
TL08_RS15045	COG2197	response regulator
TL08_RS15060	COG3629	intracellular signal transduction
TL08_RS15060	COG3903	Transcriptional regulator
TL08_RS15065	COG0667	Aldo Keto reductase
TL08_RS15105	COG0564	pseudouridine synthase activity
TL08_RS15155	COG0739	heme binding
TL08_RS15180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_RS15185	COG3959	Transketolase, thiamine diphosphate binding domain
TL08_RS15190	COG3958	Transketolase
TL08_RS15210	COG2182	Extracellular solute-binding protein
TL08_RS15215	COG1175	transmembrane transport
TL08_RS15225	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS15250	COG0740	serine-type endopeptidase activity
TL08_RS15260	COG0697	spore germination
TL08_RS15270	COG1609	Transcriptional regulator
TL08_RS15280	COG0673	inositol 2-dehydrogenase activity
TL08_RS15310	COG0395	ABC-type sugar transport system, permease component
TL08_RS15315	COG1175	transmembrane transport
TL08_RS15360	COG0346	lactoylglutathione lyase activity
TL08_RS15365	COG0640	Transcriptional regulator
TL08_RS15375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TL08_RS15385	COG0456	acetyltransferase
TL08_RS15385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TL08_RS15415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TL08_RS15420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS15440	COG0653	protein targeting
TL08_RS15445	COG0702	epimerase
TL08_RS15465	COG3340	Belongs to the peptidase S51 family
TL08_RS15510	COG1785	Belongs to the alkaline phosphatase family
TL08_RS15520	COG0477	Major facilitator Superfamily
TL08_RS15550	COG1309	transcriptional regulator
TL08_RS15560	COG3831	ATPase activity
TL08_RS15580	COG0028	Belongs to the TPP enzyme family
TL08_RS15585	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS15590	COG0277	FAD linked oxidase domain protein
TL08_RS15590	COG0247	lactate metabolic process
TL08_RS15620	COG0235	Class ii aldolase
TL08_RS15660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_RS15670	COG0697	spore germination
TL08_RS15675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_RS15690	COG3959	Transketolase, thiamine diphosphate binding domain
TL08_RS15700	COG0604	alcohol dehydrogenase
TL08_RS15700	COG3321	synthase
TL08_RS15710	COG0604	alcohol dehydrogenase
TL08_RS15710	COG3321	synthase
TL08_RS15725	COG2124	cytochrome p450
TL08_RS15740	COG3321	synthase
TL08_RS15740	COG0604	alcohol dehydrogenase
TL08_RS15795	COG3321	synthase
TL08_RS15795	COG0604	alcohol dehydrogenase
TL08_RS15800	COG0604	alcohol dehydrogenase
TL08_RS15800	COG3321	synthase
TL08_RS15810	COG0604	alcohol dehydrogenase
TL08_RS15810	COG3321	synthase
TL08_RS15850	COG2132	Multicopper oxidase
TL08_RS15875	COG4555	ABC transporter
TL08_RS15905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_RS15910	COG2409	Drug exporters of the RND superfamily
TL08_RS15920	COG0789	Transcriptional regulator
TL08_RS15925	COG0300	oxidoreductase activity
TL08_RS15930	COG2197	response regulator
TL08_RS15945	COG1131	(ABC) transporter
TL08_RS15970	COG0277	FAD linked oxidase domain protein
TL08_RS15975	COG0579	oxidoreductase
TL08_RS16005	COG2814	Major facilitator Superfamily
TL08_RS16050	COG0477	Major facilitator Superfamily
TL08_RS16085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TL08_RS16095	COG0477	Major facilitator Superfamily
TL08_RS16105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_RS16110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TL08_RS16120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TL08_RS16150	COG0577	efflux transmembrane transporter activity
TL08_RS16150	COG1136	(ABC) transporter
TL08_RS16155	COG2177	Part of the ABC transporter FtsEX involved in
TL08_RS16160	COG0137	argininosuccinate synthase activity
TL08_RS16175	COG2197	response regulator
TL08_RS16200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TL08_RS16220	COG3537	Alpha-1,2-mannosidase
TL08_RS16225	COG0028	Belongs to the TPP enzyme family
TL08_RS16290	COG0738	Major facilitator superfamily
TL08_RS16300	COG0738	Major facilitator superfamily
TL08_RS16305	COG3226	Transcriptional regulator
TL08_RS16315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS16360	COG0667	Aldo Keto reductase
TL08_RS16380	COG0596	Alpha beta hydrolase
TL08_RS16425	COG1396	sequence-specific DNA binding
TL08_RS16450	COG0583	DNA-binding transcription factor activity
TL08_RS16455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL08_RS16460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS16470	COG1505	serine-type exopeptidase activity
TL08_RS16475	COG2130	NADP-dependent
TL08_RS16485	COG5640	endopeptidase activity
TL08_RS16495	COG1733	regulation of RNA biosynthetic process
TL08_RS16515	COG0247	lactate metabolic process
TL08_RS16515	COG0277	FAD linked oxidase domain protein
TL08_RS16550	COG1105	Belongs to the carbohydrate kinase PfkB family
TL08_RS16555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TL08_RS16560	COG2814	Major facilitator Superfamily
TL08_RS16565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TL08_RS16575	COG3831	ATPase activity
TL08_RS16600	COG3831	ATPase activity
TL08_RS16605	COG3831	ATPase activity
TL08_RS16610	COG0714	Associated with various cellular activities
TL08_RS16615	COG2425	protein containing a von Willebrand factor type A (vWA) domain
TL08_RS16620	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TL08_RS16625	COG4715	Zinc finger, swim domain protein
TL08_RS16665	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TL08_RS16670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TL08_RS16710	COG2706	6-phosphogluconolactonase activity
TL08_RS16715	COG0251	oxidation-reduction process
TL08_RS16720	COG1921	L-seryl-tRNASec selenium transferase activity
TL08_RS16735	COG3842	ATPase activity
TL08_RS16800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TL08_RS16825	COG3619	membrane
TL08_RS16845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS16865	COG0702	epimerase
TL08_RS16870	COG2815	serine threonine protein kinase
TL08_RS16870	COG0515	serine threonine protein kinase
TL08_RS16895	COG2124	cytochrome p450
TL08_RS16930	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS16935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS16985	COG3250	beta-galactosidase activity
TL08_RS17010	COG0640	Transcriptional regulator
TL08_RS17015	COG0798	PFAM Bile acid sodium symporter
TL08_RS17020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TL08_RS17035	COG1278	Cold shock
TL08_RS17060	COG4565	transcriptional regulatory protein
TL08_RS17065	COG3290	protein histidine kinase activity
TL08_RS17070	COG1301	dicarboxylic acid transport
TL08_RS17075	COG0739	heme binding
TL08_RS17085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TL08_RS17175	COG1432	Conserved Protein
TL08_RS17180	COG1063	alcohol dehydrogenase
TL08_RS17190	COG0247	lactate metabolic process
TL08_RS17195	COG1139	Iron-sulfur cluster binding protein
TL08_RS17200	COG1556	Lactate utilization protein
TL08_RS17210	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS17235	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS17240	COG1129	ABC transporter
TL08_RS17325	COG0525	valine-tRNA ligase activity
TL08_RS17330	COG1136	(ABC) transporter
TL08_RS17330	COG0577	efflux transmembrane transporter activity
TL08_RS17335	COG1136	(ABC) transporter
TL08_RS17335	COG0577	efflux transmembrane transporter activity
TL08_RS17365	COG0464	growth
TL08_RS17380	COG2197	response regulator
TL08_RS17395	COG3903	Transcriptional regulator
TL08_RS17395	COG3629	intracellular signal transduction
TL08_RS17425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TL08_RS17435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TL08_RS17445	COG1082	Xylose isomerase domain protein TIM barrel
TL08_RS17455	COG5297	Belongs to the glycosyl hydrolase family 6
TL08_RS17455	COG4733	cellulase activity
TL08_RS17465	COG2723	6-phospho-beta-galactosidase activity
TL08_RS17470	COG0395	ABC-type sugar transport system, permease component
TL08_RS17495	COG1620	l-lactate permease
TL08_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS17510	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TL08_RS17520	COG0254	rRNA binding
TL08_RS17525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TL08_RS17535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TL08_RS17540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TL08_RS17545	COG0656	L-ascorbic acid biosynthetic process
TL08_RS17555	COG0438	transferase activity, transferring glycosyl groups
TL08_RS17560	COG1309	transcriptional regulator
TL08_RS17565	COG4133	protoheme IX ABC transporter activity
TL08_RS17585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TL08_RS17590	COG0739	heme binding
TL08_RS17610	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TL08_RS17615	COG0473	3-isopropylmalate dehydrogenase activity
TL08_RS17620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL08_RS17625	COG0586	Pfam SNARE associated Golgi protein
TL08_RS17630	COG0659	secondary active sulfate transmembrane transporter activity
TL08_RS17650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TL08_RS17660	COG1946	Acyl-CoA thioesterase
TL08_RS17675	COG2234	aminopeptidase activity
TL08_RS17690	COG0070	glutamate synthase
TL08_RS17690	COG0069	glutamate synthase activity
TL08_RS17690	COG0067	glutamate synthase
TL08_RS17695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TL08_RS17700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS17705	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TL08_RS17715	COG0475	glutathione-regulated potassium exporter activity
TL08_RS17720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TL08_RS17750	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS17765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TL08_RS17770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TL08_RS17780	COG0702	epimerase
TL08_RS17795	COG4585	Histidine kinase
TL08_RS17800	COG2197	response regulator
TL08_RS17820	COG0494	nUDIX hydrolase
TL08_RS17825	COG0504	CTP synthase activity
TL08_RS17845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TL08_RS17860	COG0647	UMP catabolic process
TL08_RS17895	COG2094	Belongs to the DNA glycosylase MPG family
TL08_RS17900	COG0165	Argininosuccinate lyase
TL08_RS17905	COG1438	arginine binding
TL08_RS17910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TL08_RS17920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TL08_RS17925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TL08_RS17930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TL08_RS17950	COG2855	membrane
TL08_RS17955	COG0072	phenylalanine-tRNA ligase activity
TL08_RS17955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL08_RS17960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TL08_RS17970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_RS17975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TL08_RS17980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TL08_RS18010	COG1309	transcriptional regulator
TL08_RS18015	COG3848	Pyruvate phosphate dikinase
TL08_RS18015	COG0574	Belongs to the PEP-utilizing enzyme family
TL08_RS18020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TL08_RS18030	COG0328	RNA-DNA hybrid ribonuclease activity
TL08_RS18040	COG2356	endonuclease I
TL08_RS18085	COG0494	nUDIX hydrolase
TL08_RS18090	COG1929	Belongs to the glycerate kinase type-1 family
TL08_RS18105	COG2205	protein histidine kinase activity
TL08_RS18125	COG3321	synthase
TL08_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS18125	COG0604	alcohol dehydrogenase
TL08_RS18130	COG3321	synthase
TL08_RS18130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_RS18155	COG4221	oxidoreductase activity
TL08_RS18165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_RS18210	COG1472	Belongs to the glycosyl hydrolase 3 family
TL08_RS18225	COG2072	flavoprotein involved in K transport
TL08_RS18230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL08_RS18235	COG2197	response regulator
TL08_RS18240	COG4585	Histidine kinase
TL08_RS18250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TL08_RS18255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TL08_RS18275	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
TL08_RS18300	COG0142	geranyltranstransferase activity
TL08_RS18320	COG1414	Transcriptional regulator
TL08_RS18330	COG2124	cytochrome p450
TL08_RS18485	COG0129	dihydroxy-acid dehydratase activity
TL08_RS18495	COG2318	DinB family
TL08_RS18505	COG1917	Cupin 2, conserved barrel domain protein
TL08_RS18505	COG4977	sequence-specific DNA binding
TL08_RS18560	COG1064	alcohol dehydrogenase
TL08_RS18565	COG1309	transcriptional regulator
TL08_RS18605	COG0439	Biotin carboxylase
TL08_RS18660	COG1120	ATPase activity
TL08_RS18695	COG0443	Heat shock 70 kDa protein
TL08_RS18705	COG0515	serine threonine protein kinase
TL08_RS18720	COG2197	response regulator
TL08_RS18725	COG4585	Histidine kinase
TL08_RS18735	COG1136	(ABC) transporter
TL08_RS18735	COG0577	efflux transmembrane transporter activity
TL08_RS18750	COG0579	oxidoreductase
TL08_RS18785	COG0714	Associated with various cellular activities
TL08_RS18790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TL08_RS18825	COG3467	pyridoxamine 5'-phosphate
TL08_RS18840	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL08_RS18850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_RS18880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_RS18925	COG0583	DNA-binding transcription factor activity
TL08_RS18930	COG2851	Citrate transporter
TL08_RS19025	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS19040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TL08_RS19060	COG1349	DNA-binding transcription factor activity
TL08_RS19065	COG2264	protein methyltransferase activity
TL08_RS19070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_RS19070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS19080	COG1404	Belongs to the peptidase S8 family
TL08_RS19085	COG1404	Belongs to the peptidase S8 family
TL08_RS19120	COG1175	transmembrane transport
TL08_RS19125	COG0395	ABC-type sugar transport system, permease component
TL08_RS19150	COG2357	RelA SpoT domain protein
TL08_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS19175	COG2124	cytochrome p450
TL08_RS19190	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TL08_RS19195	COG2315	Protein conserved in bacteria
TL08_RS19215	COG0747	negative chemotaxis
TL08_RS19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS19245	COG1414	Transcriptional regulator
TL08_RS19250	COG1063	alcohol dehydrogenase
TL08_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS19265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TL08_RS19270	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS19290	COG0297	glycogen (starch) synthase activity
TL08_RS19310	COG2192	nodulation
TL08_RS19315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TL08_RS19320	COG0859	PFAM glycosyl transferase family 9
TL08_RS19325	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TL08_RS19330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TL08_RS19330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TL08_RS19345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TL08_RS19355	COG0587	DNA-directed DNA polymerase activity
TL08_RS19385	COG2132	Multicopper oxidase
TL08_RS19390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TL08_RS19400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_RS19405	COG0583	DNA-binding transcription factor activity
TL08_RS19410	COG4166	transmembrane transport
TL08_RS19415	COG0601	transmembrane transport
TL08_RS19420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_RS19425	COG0444	Belongs to the ABC transporter superfamily
TL08_RS19430	COG4608	Belongs to the ABC transporter superfamily
TL08_RS19445	COG0640	Transcriptional regulator
TL08_RS19465	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS19470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TL08_RS19475	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS19480	COG1414	Transcriptional regulator
TL08_RS19505	COG2814	Major facilitator Superfamily
TL08_RS19515	COG0667	Aldo Keto reductase
TL08_RS19570	COG1280	lysine exporter protein (LysE YggA)
TL08_RS19585	COG0402	S-adenosylhomocysteine deaminase activity
TL08_RS19610	COG0477	Major facilitator Superfamily
TL08_RS19615	COG0477	Major facilitator Superfamily
TL08_RS19635	COG2390	Transcriptional regulator
TL08_RS19640	COG1063	alcohol dehydrogenase
TL08_RS19655	COG0395	ABC-type sugar transport system, permease component
TL08_RS19660	COG1309	transcriptional regulator
TL08_RS19680	COG0243	molybdopterin cofactor binding
TL08_RS19695	COG0667	Aldo Keto reductase
TL08_RS19700	COG5000	phosphorelay sensor kinase activity
TL08_RS19705	COG0037	tRNA processing
TL08_RS19705	COG0590	tRNA wobble adenosine to inosine editing
TL08_RS19720	COG2124	cytochrome p450
TL08_RS19725	COG2124	cytochrome p450
TL08_RS19730	COG0697	spore germination
TL08_RS19735	COG3903	Transcriptional regulator
TL08_RS19735	COG3629	intracellular signal transduction
TL08_RS19775	COG1857	crispr-associated protein
TL08_RS19810	COG3401	FG-GAP repeat protein
TL08_RS19815	COG1309	transcriptional regulator
TL08_RS19860	COG1857	crispr-associated protein
TL08_RS19900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TL08_RS19910	COG2183	response to ionizing radiation
TL08_RS19925	COG4585	Histidine kinase
TL08_RS19930	COG2197	response regulator
TL08_RS19935	COG1271	oxidase subunit
TL08_RS19945	COG4988	ABC transporter
TL08_RS19950	COG1132	(ABC) transporter
TL08_RS19985	COG1120	ATPase activity
TL08_RS19990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS20040	COG1366	Belongs to the anti-sigma-factor antagonist family
TL08_RS20075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TL08_RS20085	COG0693	protein deglycase activity
TL08_RS20110	COG0248	Ppx GppA phosphatase
TL08_RS20115	COG3842	ATPase activity
TL08_RS20120	COG1609	Transcriptional regulator
TL08_RS20135	COG1609	Transcriptional regulator
TL08_RS20165	COG2755	lipolytic protein G-D-S-L family
TL08_RS20170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TL08_RS20180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_RS20180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_RS20185	COG1302	Protein conserved in bacteria
TL08_RS20215	COG1793	dna ligase
TL08_RS20225	COG0124	histidyl-tRNA synthetase
TL08_RS20235	COG1320	monovalent cation:proton antiporter activity
TL08_RS20245	COG1863	multisubunit Na H antiporter MnhE subunit
TL08_RS20250	COG0651	ATP synthesis coupled electron transport
TL08_RS20255	COG1006	Multisubunit Na H antiporter MnhC subunit
TL08_RS20260	COG2111	Na H antiporter
TL08_RS20260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TL08_RS20275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TL08_RS20285	COG3253	May function as heme-dependent peroxidase
TL08_RS20290	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TL08_RS20295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TL08_RS20305	COG2197	response regulator
TL08_RS20335	COG0183	Belongs to the thiolase family
TL08_RS20340	COG1024	Enoyl-CoA hydratase
TL08_RS20340	COG1250	3-hydroxyacyl-CoA dehydrogenase
TL08_RS20355	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_RS20360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TL08_RS20365	COG0673	inositol 2-dehydrogenase activity
TL08_RS20370	COG1653	transport
TL08_RS20375	COG1175	transmembrane transport
TL08_RS20380	COG0395	ABC-type sugar transport system, permease component
TL08_RS20400	COG3866	Pectate lyase
TL08_RS20410	COG3507	Belongs to the glycosyl hydrolase 43 family
TL08_RS20435	COG1070	Carbohydrate kinase
TL08_RS20445	COG3347	Dehydrogenase
TL08_RS20445	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS20450	COG4952	isomerase
TL08_RS20455	COG3254	rhamnose metabolic process
TL08_RS20460	COG1609	Transcriptional regulator
TL08_RS20490	COG0673	inositol 2-dehydrogenase activity
TL08_RS20505	COG5297	Belongs to the glycosyl hydrolase family 6
TL08_RS20535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TL08_RS20535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TL08_RS20555	COG0823	Involved in the tonB-independent uptake of proteins
TL08_RS20555	COG1506	peptidase
TL08_RS20610	COG2197	response regulator
TL08_RS20640	COG0702	epimerase
TL08_RS20645	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TL08_RS20685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TL08_RS20705	COG1309	transcriptional regulator
TL08_RS20745	COG0494	nUDIX hydrolase
TL08_RS20755	COG5001	Diguanylate cyclase
TL08_RS20810	COG2197	response regulator
TL08_RS20815	COG4585	Histidine kinase
TL08_RS20845	COG2311	Membrane
TL08_RS20860	COG2197	response regulator
TL08_RS20865	COG4585	Histidine kinase
TL08_RS20875	COG1131	(ABC) transporter
TL08_RS20885	COG0596	Alpha beta hydrolase
TL08_RS20895	COG1902	pentaerythritol trinitrate reductase activity
TL08_RS20910	COG4106	trans-aconitate 2-methyltransferase activity
TL08_RS20920	COG0358	DNA primase activity
TL08_RS20925	COG1595	DNA-templated transcription, initiation
TL08_RS20935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TL08_RS20945	COG3340	Belongs to the peptidase S51 family
TL08_RS20950	COG0423	glycine-tRNA ligase activity
TL08_RS20985	COG0701	Predicted permease
TL08_RS20995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TL08_RS21020	COG1131	(ABC) transporter
TL08_RS21025	COG2188	Transcriptional regulator
TL08_RS21030	COG1381	Involved in DNA repair and RecF pathway recombination
TL08_RS21045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TL08_RS21065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TL08_RS21075	COG0537	adenosine 5'-monophosphoramidase activity
TL08_RS21085	COG0484	heat shock protein binding
TL08_RS21090	COG1420	regulation of RNA biosynthetic process
TL08_RS21130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TL08_RS21135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_RS21165	COG0604	alcohol dehydrogenase
TL08_RS21190	COG0443	Heat shock 70 kDa protein
TL08_RS21195	COG1201	RNA secondary structure unwinding
TL08_RS21235	COG0142	geranyltranstransferase activity
TL08_RS21250	COG2815	serine threonine protein kinase
TL08_RS21250	COG0515	serine threonine protein kinase
TL08_RS21260	COG2268	Band 7 protein
TL08_RS21280	COG0584	glycerophosphoryl diester phosphodiesterase
TL08_RS21290	COG0583	DNA-binding transcription factor activity
TL08_RS21305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TL08_RS21310	COG3209	COG3209 Rhs family protein
TL08_RS21320	COG3209	COG3209 Rhs family protein
TL08_RS21360	COG1940	carbohydrate kinase activity
TL08_RS21370	COG0003	Pfam Anion-transporting ATPase
TL08_RS21395	COG0438	transferase activity, transferring glycosyl groups
TL08_RS21435	COG2010	Cytochrome c
TL08_RS21440	COG1845	cytochrome c oxidase, subunit III
TL08_RS21455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TL08_RS21465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TL08_RS21475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TL08_RS21495	COG0667	Aldo Keto reductase
TL08_RS21510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TL08_RS21515	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TL08_RS21520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TL08_RS21535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TL08_RS21545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TL08_RS21560	COG0321	lipoyl(octanoyl) transferase activity
TL08_RS21570	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS21575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TL08_RS21595	COG0174	glutamine synthetase
TL08_RS21605	COG1733	regulation of RNA biosynthetic process
TL08_RS21610	COG0702	epimerase
TL08_RS21625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TL08_RS21655	COG0174	glutamine synthetase
TL08_RS21665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TL08_RS21665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TL08_RS21670	COG2318	DinB family
TL08_RS21675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TL08_RS21680	COG0435	Glutathione S-transferase
TL08_RS21810	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TL08_RS21830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TL08_RS21845	COG2239	Acts as a magnesium transporter
TL08_RS21865	COG3201	nicotinamide mononucleotide transporter
TL08_RS21870	COG0668	transmembrane transport
TL08_RS21885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TL08_RS21890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TL08_RS21895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_RS21970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TL08_RS22010	COG1254	Belongs to the acylphosphatase family
TL08_RS22015	COG2340	Cysteine-rich secretory protein family
TL08_RS22035	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TL08_RS22045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TL08_RS22060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TL08_RS22065	COG0571	ribonuclease III activity
TL08_RS22085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TL08_RS22090	COG0742	ribosomal rna small subunit methyltransferase
TL08_RS22100	COG1846	Transcriptional regulator
TL08_RS22160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TL08_RS22165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TL08_RS22180	COG0431	NADPH-dependent FMN reductase
TL08_RS22180	COG1053	succinate dehydrogenase
TL08_RS22180	COG3976	FMN-binding domain protein
TL08_RS22200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TL08_RS22205	COG1461	Dihydroxyacetone kinase
TL08_RS22210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TL08_RS22215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TL08_RS22250	COG1725	Transcriptional regulator
TL08_RS22255	COG1131	(ABC) transporter
TL08_RS22275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_RS22290	COG0626	cystathionine gamma-synthase activity
TL08_RS22295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TL08_RS22305	COG1920	GTP binding
TL08_RS22325	COG0066	3-isopropylmalate dehydratase activity
TL08_RS22330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TL08_RS22350	COG1011	Hydrolase
TL08_RS22355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TL08_RS22365	COG0179	Fumarylacetoacetate (FAA) hydrolase
TL08_RS22370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TL08_RS22380	COG0473	3-isopropylmalate dehydrogenase activity
TL08_RS22385	COG1404	Belongs to the peptidase S8 family
TL08_RS22400	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TL08_RS22405	COG0440	acetolactate synthase activity
TL08_RS22420	COG0129	dihydroxy-acid dehydratase activity
TL08_RS22440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TL08_RS22440	COG0515	serine threonine protein kinase
TL08_RS22460	COG2259	Doxx family
TL08_RS22480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TL08_RS22495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TL08_RS22500	COG0154	amidase activity
TL08_RS22505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TL08_RS22520	COG0456	acetyltransferase
TL08_RS22520	COG1214	PFAM Peptidase M22, glycoprotease
TL08_RS22525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TL08_RS22530	COG1253	flavin adenine dinucleotide binding
TL08_RS22545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TL08_RS22550	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TL08_RS22570	COG0596	Alpha beta hydrolase
TL08_RS22570	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_RS22590	COG1960	acyl-CoA dehydrogenase activity
TL08_RS22600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TL08_RS22605	COG1309	transcriptional regulator
TL08_RS22640	COG2149	membrane
TL08_RS22650	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TL08_RS22650	COG2508	Transcriptional regulator
TL08_RS22655	COG0686	Belongs to the AlaDH PNT family
TL08_RS22680	COG1132	(ABC) transporter
TL08_RS22685	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_RS22685	COG0567	Dehydrogenase, E1 component
TL08_RS22710	COG1228	amidohydrolase
TL08_RS22745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TL08_RS22750	COG2986	histidine ammonia-lyase
TL08_RS22775	COG1174	glycine betaine transport
TL08_RS22780	COG1174	glycine betaine transport
TL08_RS22785	COG1125	glycine betaine transport
TL08_RS22785	COG0517	IMP dehydrogenase activity
TL08_RS22820	COG0406	alpha-ribazole phosphatase activity
TL08_RS22840	COG1597	lipid kinase activity
TL08_RS22855	COG5662	AntiSigma factor
TL08_RS22875	COG2135	peptidase activity
TL08_RS22880	COG2135	peptidase activity
TL08_RS22885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TL08_RS22890	COG1162	GTPase activity
TL08_RS22905	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS22920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_RS22925	COG1011	Hydrolase
TL08_RS22935	COG0653	protein targeting
TL08_RS22940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TL08_RS22965	COG5000	phosphorelay sensor kinase activity
TL08_RS22965	COG5002	protein histidine kinase activity
TL08_RS22970	COG0745	RESPONSE REGULATOR receiver
TL08_RS23010	COG0531	amino acid
TL08_RS23015	COG1482	cell wall glycoprotein biosynthetic process
TL08_RS23025	COG2835	tetraacyldisaccharide 4'-kinase activity
TL08_RS23050	COG1994	Peptidase M50
TL08_RS23055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TL08_RS23060	COG0778	Nitroreductase
TL08_RS23060	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TL08_RS23100	COG0438	transferase activity, transferring glycosyl groups
TL08_RS23115	COG1316	TRANSCRIPTIONal
TL08_RS23120	COG1316	TRANSCRIPTIONal
TL08_RS23145	COG1131	(ABC) transporter
TL08_RS23170	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS23175	COG1129	ABC transporter
TL08_RS23190	COG1690	Belongs to the RtcB family
TL08_RS23195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TL08_RS23225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TL08_RS23230	COG2205	protein histidine kinase activity
TL08_RS23235	COG0745	RESPONSE REGULATOR receiver
TL08_RS23240	COG0483	inositol monophosphate 1-phosphatase activity
TL08_RS23295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TL08_RS23320	COG0739	heme binding
TL08_RS23325	COG2936	dipeptidyl-peptidase activity
TL08_RS23375	COG1840	ABC-type Fe3 transport system, periplasmic component
TL08_RS23385	COG3842	ATPase activity
TL08_RS23390	COG2828	Protein conserved in bacteria
TL08_RS23395	COG0583	DNA-binding transcription factor activity
TL08_RS23410	COG1823	symporter activity
TL08_RS23415	COG4770	biotin carboxylase activity
TL08_RS23455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TL08_RS23460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TL08_RS23465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TL08_RS23490	COG1473	amidohydrolase
TL08_RS23490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TL08_RS23525	COG0084	hydrolase, TatD family'
TL08_RS23540	COG0109	protoheme IX farnesyltransferase activity
TL08_RS23565	COG1879	ABC-type sugar transport system periplasmic component
TL08_RS23570	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS23575	COG1129	ABC transporter
TL08_RS23585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_RS23605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TL08_RS23615	COG4585	Histidine kinase
TL08_RS23620	COG1131	(ABC) transporter
TL08_RS23630	COG1940	carbohydrate kinase activity
TL08_RS23635	COG1070	Carbohydrate kinase
TL08_RS23655	COG1320	monovalent cation:proton antiporter activity
TL08_RS23670	COG0651	ATP synthesis coupled electron transport
TL08_RS23675	COG1006	Multisubunit Na H antiporter MnhC subunit
TL08_RS23685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TL08_RS23685	COG2111	Na H antiporter
TL08_RS23690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_RS23690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_RS23695	COG0515	serine threonine protein kinase
TL08_RS23705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TL08_RS23710	COG0667	Aldo Keto reductase
TL08_RS23730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TL08_RS23740	COG4585	Histidine kinase
TL08_RS23745	COG2197	response regulator
TL08_RS23755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_RS23775	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS23795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_RS23810	COG3629	intracellular signal transduction
TL08_RS23815	COG2030	dehydratase
TL08_RS23830	COG2409	Drug exporters of the RND superfamily
TL08_RS23850	COG2409	Drug exporters of the RND superfamily
TL08_RS23900	COG0604	alcohol dehydrogenase
TL08_RS23905	COG1309	transcriptional regulator
TL08_RS23930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TL08_RS23935	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS23940	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS23970	COG1131	(ABC) transporter
TL08_RS23995	COG1131	(ABC) transporter
TL08_RS24020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TL08_RS24040	COG1079	Belongs to the binding-protein-dependent transport system permease family
TL08_RS24050	COG3845	ABC transporter
TL08_RS24055	COG1744	ABC transporter substrate-binding protein PnrA-like
TL08_RS24060	COG2009	succinate dehydrogenase
TL08_RS24075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TL08_RS24080	COG1686	Belongs to the peptidase S11 family
TL08_RS24085	COG1295	ribonuclease BN
TL08_RS24100	COG0708	Exodeoxyribonuclease III
TL08_RS24140	COG0039	L-malate dehydrogenase activity
TL08_RS24155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TL08_RS24185	COG0587	DNA-directed DNA polymerase activity
TL08_RS24230	COG0045	succinate-CoA ligase (ADP-forming) activity
TL08_RS24235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_RS24245	COG0739	heme binding
TL08_RS24250	COG0739	heme binding
TL08_RS24290	COG0586	Pfam SNARE associated Golgi protein
TL08_RS24325	COG0515	serine threonine protein kinase
TL08_RS24330	COG0583	DNA-binding transcription factor activity
TL08_RS24375	COG0519	Catalyzes the synthesis of GMP from XMP
TL08_RS24375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TL08_RS24380	COG1012	belongs to the aldehyde dehydrogenase family
TL08_RS24390	COG0697	spore germination
TL08_RS24400	COG0516	GMP reductase activity
TL08_RS24440	COG0459	protein refolding
TL08_RS24445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TL08_RS24450	COG3540	Alkaline phosphatase
TL08_RS24455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TL08_RS24460	COG0456	acetyltransferase
TL08_RS24470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TL08_RS24480	COG0802	atpase or kinase
TL08_RS24495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TL08_RS24505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TL08_RS24545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TL08_RS24550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TL08_RS24555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TL08_RS24580	COG1674	ftsk spoiiie
TL08_RS24590	COG1404	Belongs to the peptidase S8 family
TL08_RS24665	COG4122	O-methyltransferase activity
TL08_RS24690	COG1674	ftsk spoiiie
TL08_RS24700	COG0456	acetyltransferase
TL08_RS24705	COG2130	NADP-dependent
TL08_RS24710	COG3800	Transcriptional regulator
TL08_RS24710	COG1396	sequence-specific DNA binding
TL08_RS24720	COG4152	abc transporter atp-binding protein
TL08_RS24725	COG1668	transmembrane transport
TL08_RS24730	COG0415	Belongs to the DNA photolyase family
TL08_RS24745	COG1228	amidohydrolase
TL08_RS24750	COG2017	converts alpha-aldose to the beta-anomer
TL08_RS24755	COG0531	amino acid
TL08_RS24760	COG0477	Major facilitator Superfamily
TL08_RS24765	COG0259	pyridoxamine-phosphate oxidase activity
TL08_RS24795	COG1132	(ABC) transporter
TL08_RS24800	COG1132	(ABC) transporter
TL08_RS24810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_RS24820	COG2814	Major facilitator Superfamily
TL08_RS24830	COG2252	PERMEase
TL08_RS24855	COG2814	Major facilitator Superfamily
TL08_RS24865	COG1278	Cold shock
TL08_RS24880	COG0384	phenazine biosynthesis protein PhzF
TL08_RS24895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TL08_RS24905	COG1652	LysM domain
TL08_RS24945	COG2018	Roadblock/LC7 domain
TL08_RS24970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_RS24975	COG1116	anion transmembrane transporter activity
TL08_RS24985	COG1061	Type III restriction enzyme res subunit
TL08_RS25015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TL08_RS25045	COG0459	protein refolding
TL08_RS25070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TL08_RS25075	COG0667	Aldo Keto reductase
TL08_RS25085	COG0167	dihydroorotate dehydrogenase activity
TL08_RS25130	COG2733	membrane
TL08_RS25150	COG1404	Belongs to the peptidase S8 family
TL08_RS25175	COG3973	AAA domain
TL08_RS25195	COG1733	regulation of RNA biosynthetic process
TL08_RS25205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TL08_RS25205	COG2169	Transcriptional regulator
TL08_RS25215	COG0519	Catalyzes the synthesis of GMP from XMP
TL08_RS25230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_RS25235	COG2364	Membrane
TL08_RS25245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TL08_RS25270	COG0463	Glycosyl transferase, family 2
TL08_RS25290	COG1216	Glycosyl transferase, family 2
TL08_RS25355	COG1316	TRANSCRIPTIONal
TL08_RS25375	COG1960	acyl-CoA dehydrogenase activity
TL08_RS25380	COG1522	sequence-specific DNA binding
TL08_RS25465	COG1414	Transcriptional regulator
TL08_RS25470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TL08_RS25475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TL08_RS25505	COG0704	Plays a role in the regulation of phosphate uptake
TL08_RS25515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TL08_RS25520	COG0581	inorganic phosphate transmembrane transporter activity
TL08_RS25535	COG0456	acetyltransferase
TL08_RS25540	COG0745	RESPONSE REGULATOR receiver
TL08_RS25575	COG4044	May play a role in the intracellular transport of hydrophobic ligands
TL08_RS25590	COG0354	folic acid binding
TL08_RS25640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TL08_RS25655	COG3387	PFAM Glycoside hydrolase 15-related
TL08_RS25680	COG0047	phosphoribosylformylglycinamidine synthase activity
TL08_RS25685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TL08_RS25695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TL08_RS25715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TL08_RS25725	COG1595	DNA-templated transcription, initiation
TL08_RS25730	COG0789	Transcriptional regulator
TL08_RS25745	COG2076	Multidrug Resistance protein
TL08_RS25755	COG1595	DNA-templated transcription, initiation
TL08_RS25775	COG0436	Aminotransferase
TL08_RS25795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TL08_RS25815	COG4129	membrane
TL08_RS25870	COG0277	FAD linked oxidase domain protein
TL08_RS25880	COG2197	response regulator
TL08_RS25900	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TL08_RS25910	COG0443	Heat shock 70 kDa protein
TL08_RS25965	COG1115	amino acid carrier protein
TL08_RS25970	COG0471	metal ion transport
TL08_RS25975	COG0542	response to heat
TL08_RS26000	COG0596	Alpha beta hydrolase
TL08_RS26025	COG1704	LemA family
TL08_RS26030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_RS26050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TL08_RS26065	COG0789	Transcriptional regulator
TL08_RS26070	COG0484	heat shock protein binding
TL08_RS26075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TL08_RS26080	COG0443	Heat shock 70 kDa protein
TL08_RS26090	COG2181	nitrate reductase activity
TL08_RS26090	COG0247	lactate metabolic process
TL08_RS26120	COG0686	Belongs to the AlaDH PNT family
TL08_RS26140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TL08_RS26180	COG1120	ATPase activity
TL08_RS26185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_RS26200	COG5398	heme oxygenase
TL08_RS26210	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_RS26235	COG0546	phosphoglycolate phosphatase activity
TL08_RS26250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TL08_RS26260	COG0477	Major facilitator Superfamily
TL08_RS26275	COG0583	DNA-binding transcription factor activity
TL08_RS26280	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TL08_RS26285	COG1960	acyl-CoA dehydrogenase activity
TL08_RS26310	COG1309	transcriptional regulator
TL08_RS26320	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TL08_RS26345	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TL08_RS26355	COG1126	abc transporter atp-binding protein
TL08_RS26360	COG0765	amino acid transport
TL08_RS26365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL08_RS26375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TL08_RS26385	COG0022	dehydrogenase e1 component
TL08_RS26390	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_RS26410	COG0300	oxidoreductase activity
TL08_RS26420	COG3339	Conserved Protein
TL08_RS26425	COG1260	myo-inositol-1-phosphate synthase
TL08_RS26445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL08_RS26465	COG0360	Binds together with S18 to 16S ribosomal RNA
TL08_RS26470	COG0629	single-stranded DNA binding
TL08_RS26475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TL08_RS26485	COG0305	Participates in initiation and elongation during chromosome replication
TL08_RS26520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TL08_RS26575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TL08_RS26580	COG1869	D-ribose catabolic process
TL08_RS26585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TL08_RS26590	COG1879	ABC-type sugar transport system periplasmic component
TL08_RS26595	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_RS26600	COG1129	ABC transporter
TL08_RS26605	COG1609	Transcriptional regulator
TL08_RS26625	COG0495	leucyl-tRNA aminoacylation
TL08_RS26655	COG1678	Uncharacterized ACR, COG1678
TL08_RS26670	COG0617	tRNA 3'-terminal CCA addition
TL08_RS26690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TL08_RS26690	COG0515	serine threonine protein kinase
TL08_RS26695	COG1595	DNA-templated transcription, initiation
TL08_RS26715	COG3409	Peptidoglycan-binding domain 1 protein
TL08_RS26715	COG0860	N-Acetylmuramoyl-L-alanine amidase
TL08_RS26725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_RS26730	COG1181	Belongs to the D-alanine--D-alanine ligase family
TL08_RS26740	COG1192	Involved in chromosome partitioning
TL08_RS26745	COG0357	Ribosomal RNA small subunit methyltransferase G
TL08_RS26765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TL08_RS26770	COG0594	ribonuclease P activity
TL08_RS26775	COG0230	Belongs to the bacterial ribosomal protein bL34 family