locus-tag	class	description
C1701_RS00015	COG0477	Major facilitator Superfamily
C1701_RS00030	COG1819	glycosyl
C1701_RS00045	COG0596	Alpha beta hydrolase
C1701_RS00055	COG2197	response regulator
C1701_RS00060	COG0596	Alpha beta hydrolase
C1701_RS00070	COG1063	alcohol dehydrogenase
C1701_RS00100	COG2267	carboxylic ester hydrolase activity
C1701_RS00110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1701_RS00140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS00145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1701_RS00155	COG1309	transcriptional regulator
C1701_RS00160	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS00185	COG1131	(ABC) transporter
C1701_RS00200	COG2197	response regulator
C1701_RS00220	COG2409	Drug exporters of the RND superfamily
C1701_RS00230	COG2264	protein methyltransferase activity
C1701_RS00235	COG1785	Belongs to the alkaline phosphatase family
C1701_RS00315	COG0477	Major facilitator Superfamily
C1701_RS00335	COG2197	response regulator
C1701_RS00345	COG4585	Histidine kinase
C1701_RS00355	COG1136	(ABC) transporter
C1701_RS00355	COG0577	efflux transmembrane transporter activity
C1701_RS00365	COG1131	(ABC) transporter
C1701_RS00370	COG4585	Histidine kinase
C1701_RS00375	COG2197	response regulator
C1701_RS00380	COG0656	L-ascorbic acid biosynthetic process
C1701_RS00410	COG1120	ATPase activity
C1701_RS00415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS00440	COG3629	intracellular signal transduction
C1701_RS00455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1701_RS00505	COG2124	cytochrome p450
C1701_RS00535	COG0259	pyridoxamine-phosphate oxidase activity
C1701_RS00555	COG1733	regulation of RNA biosynthetic process
C1701_RS00575	COG1518	maintenance of DNA repeat elements
C1701_RS00590	COG1857	crispr-associated protein
C1701_RS00630	COG1024	Enoyl-CoA hydratase
C1701_RS00635	COG1960	acyl-CoA dehydrogenase activity
C1701_RS00655	COG1960	acyl-CoA dehydrogenase activity
C1701_RS00665	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1701_RS00685	COG0604	alcohol dehydrogenase
C1701_RS00685	COG3321	synthase
C1701_RS00690	COG0604	alcohol dehydrogenase
C1701_RS00690	COG3321	synthase
C1701_RS00695	COG0604	alcohol dehydrogenase
C1701_RS00695	COG3321	synthase
C1701_RS00700	COG0604	alcohol dehydrogenase
C1701_RS00700	COG3321	synthase
C1701_RS00700	COG0604	alcohol dehydrogenase
C1701_RS00700	COG3321	synthase
C1701_RS00730	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS00755	COG2197	response regulator
C1701_RS00795	COG1819	glycosyl
C1701_RS00825	COG2079	MmgE PrpD family protein
C1701_RS00830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1701_RS00855	COG2814	Major facilitator Superfamily
C1701_RS00860	COG1309	transcriptional regulator
C1701_RS00865	COG2375	cellular response to nickel ion
C1701_RS00865	COG1132	(ABC) transporter
C1701_RS00870	COG1132	(ABC) transporter
C1701_RS00875	COG1960	acyl-CoA dehydrogenase activity
C1701_RS00885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1701_RS00900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1701_RS00920	COG1960	acyl-CoA dehydrogenase activity
C1701_RS00965	COG1733	regulation of RNA biosynthetic process
C1701_RS01000	COG1132	(ABC) transporter
C1701_RS01010	COG0667	Aldo Keto reductase
C1701_RS01050	COG2197	response regulator
C1701_RS01065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1701_RS01070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1701_RS01100	COG4585	Histidine kinase
C1701_RS01140	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1701_RS01155	COG0825	malonyl-CoA metabolic process
C1701_RS01155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1701_RS01160	COG0318	PFAM AMP-dependent synthetase and ligase
C1701_RS01195	COG0402	S-adenosylhomocysteine deaminase activity
C1701_RS01200	COG0477	Major facilitator Superfamily
C1701_RS01235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS01250	COG0596	Alpha beta hydrolase
C1701_RS01260	COG1960	acyl-CoA dehydrogenase activity
C1701_RS01275	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1701_RS01280	COG0411	ABC transporter
C1701_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS01300	COG1960	acyl-CoA dehydrogenase activity
C1701_RS01310	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1701_RS01320	COG0183	Belongs to the thiolase family
C1701_RS01330	COG2508	Transcriptional regulator
C1701_RS01360	COG1203	CRISPR-associated helicase, Cas3
C1701_RS01370	COG1518	maintenance of DNA repeat elements
C1701_RS01375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C1701_RS01385	COG0318	PFAM AMP-dependent synthetase and ligase
C1701_RS01400	COG1960	acyl-CoA dehydrogenase activity
C1701_RS01410	COG0514	ATP-dependent DNA helicase (RecQ)
C1701_RS01425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1701_RS01470	COG1511	domain protein
C1701_RS01470	COG0842	Transport permease protein
C1701_RS01475	COG1131	(ABC) transporter
C1701_RS01500	COG0596	Alpha beta hydrolase
C1701_RS01515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1701_RS01520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1701_RS01525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1701_RS01530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1701_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS01545	COG3903	Transcriptional regulator
C1701_RS01545	COG3629	intracellular signal transduction
C1701_RS01550	COG1819	glycosyl
C1701_RS01600	COG0673	inositol 2-dehydrogenase activity
C1701_RS01610	COG0673	inositol 2-dehydrogenase activity
C1701_RS01640	COG1131	(ABC) transporter
C1701_RS01645	COG1309	transcriptional regulator
C1701_RS01660	COG1253	flavin adenine dinucleotide binding
C1701_RS01665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1701_RS01670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1701_RS01675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1701_RS01680	COG1116	anion transmembrane transporter activity
C1701_RS01685	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1701_RS01725	COG0431	NADPH-dependent FMN reductase
C1701_RS01755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1701_RS01760	COG0181	hydroxymethylbilane synthase activity
C1701_RS01765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1701_RS01770	COG0697	spore germination
C1701_RS01775	COG4581	dead DEAH box helicase
C1701_RS01790	COG3507	Belongs to the glycosyl hydrolase 43 family
C1701_RS01805	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1701_RS01810	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1701_RS01815	COG1129	ABC transporter
C1701_RS01825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1701_RS01885	COG4221	oxidoreductase activity
C1701_RS01885	COG3321	synthase
C1701_RS01885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS01885	COG0604	alcohol dehydrogenase
C1701_RS01905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1701_RS01935	COG0596	Alpha beta hydrolase
C1701_RS01965	COG0402	S-adenosylhomocysteine deaminase activity
C1701_RS01975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1701_RS01995	COG0589	response to stress
C1701_RS02000	COG1414	Transcriptional regulator
C1701_RS02005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1701_RS02010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1701_RS02015	COG0667	Aldo Keto reductase
C1701_RS02025	COG0737	Belongs to the 5'-nucleotidase family
C1701_RS02035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1701_RS02065	COG0640	Transcriptional regulator
C1701_RS02085	COG2815	serine threonine protein kinase
C1701_RS02085	COG0515	serine threonine protein kinase
C1701_RS02095	COG1770	oligopeptidase
C1701_RS02125	COG0318	PFAM AMP-dependent synthetase and ligase
C1701_RS02130	COG1432	Conserved Protein
C1701_RS02140	COG1324	tolerance protein
C1701_RS02170	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1701_RS02180	COG1121	(ABC) transporter
C1701_RS02185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1701_RS02240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS02245	COG1309	transcriptional regulator
C1701_RS02250	COG1132	(ABC) transporter
C1701_RS02255	COG0702	epimerase
C1701_RS02260	COG2032	superoxide dismutase activity
C1701_RS02285	COG1285	pathogenesis
C1701_RS02290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1701_RS02300	COG3959	Transketolase, thiamine diphosphate binding domain
C1701_RS02305	COG3958	Transketolase
C1701_RS02320	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS02325	COG3401	FG-GAP repeat protein
C1701_RS02350	COG0439	Biotin carboxylase
C1701_RS02355	COG0511	ligase activity, forming carbon-carbon bonds
C1701_RS02360	COG0825	malonyl-CoA metabolic process
C1701_RS02360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1701_RS02395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1701_RS02405	COG0662	Cupin 2, conserved barrel domain protein
C1701_RS02425	COG3629	intracellular signal transduction
C1701_RS02425	COG3903	Transcriptional regulator
C1701_RS02480	COG0488	(ABC) transporter
C1701_RS02520	COG2188	Transcriptional regulator
C1701_RS02525	COG0477	Major facilitator Superfamily
C1701_RS02535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS02540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1701_RS02560	COG0640	Transcriptional regulator
C1701_RS02610	COG3250	beta-galactosidase activity
C1701_RS02615	COG4608	Belongs to the ABC transporter superfamily
C1701_RS02620	COG0444	Belongs to the ABC transporter superfamily
C1701_RS02625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS02630	COG0601	transmembrane transport
C1701_RS02645	COG3458	cephalosporin-C deacetylase activity
C1701_RS02675	COG2390	Transcriptional regulator
C1701_RS02695	COG0395	ABC-type sugar transport system, permease component
C1701_RS02735	COG1649	PFAM Uncharacterised BCR, COG1649
C1701_RS02770	COG0405	Gamma-glutamyltransferase
C1701_RS02840	COG2072	flavoprotein involved in K transport
C1701_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS02860	COG0326	Molecular chaperone. Has ATPase activity
C1701_RS02870	COG3340	Belongs to the peptidase S51 family
C1701_RS02880	COG1846	Transcriptional regulator
C1701_RS02880	COG1940	carbohydrate kinase activity
C1701_RS02925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1701_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS02935	COG1309	transcriptional regulator
C1701_RS02945	COG1940	carbohydrate kinase activity
C1701_RS02975	COG0596	Alpha beta hydrolase
C1701_RS02985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1701_RS02990	COG2151	metal-sulfur cluster biosynthetic enzyme
C1701_RS02995	COG3396	Phenylacetate-CoA oxygenase
C1701_RS03000	COG3460	Phenylacetate-CoA oxygenase
C1701_RS03005	COG3396	Phenylacetate-CoA oxygenase
C1701_RS03010	COG2030	dehydratase
C1701_RS03010	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS03015	COG1024	Enoyl-CoA hydratase
C1701_RS03065	COG1309	transcriptional regulator
C1701_RS03085	COG1196	nuclear chromosome segregation
C1701_RS03085	COG0741	lytic transglycosylase activity
C1701_RS03085	COG0739	heme binding
C1701_RS03090	COG0515	serine threonine protein kinase
C1701_RS03145	COG0515	serine threonine protein kinase
C1701_RS03150	COG1960	acyl-CoA dehydrogenase activity
C1701_RS03160	COG4122	O-methyltransferase activity
C1701_RS03175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1701_RS03180	COG3387	PFAM Glycoside hydrolase 15-related
C1701_RS03185	COG2267	carboxylic ester hydrolase activity
C1701_RS03195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1701_RS03200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1701_RS03200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1701_RS03215	COG2040	homocysteine
C1701_RS03225	COG0242	peptide deformylase activity
C1701_RS03230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1701_RS03240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1701_RS03245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1701_RS03250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1701_RS03260	COG1758	RNA polymerase activity
C1701_RS03265	COG0194	GDP metabolic process
C1701_RS03280	COG0284	orotidine-5'-phosphate decarboxylase activity
C1701_RS03290	COG0505	Belongs to the CarA family
C1701_RS03305	COG0540	Belongs to the ATCase OTCase family
C1701_RS03320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1701_RS03325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1701_RS03330	COG0006	proline dipeptidase activity
C1701_RS03345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1701_RS03365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1701_RS03370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1701_RS03375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1701_RS03385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1701_RS03390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1701_RS03405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1701_RS03410	COG1263	PTS System
C1701_RS03415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1701_RS03420	COG1053	succinate dehydrogenase
C1701_RS03430	COG0583	DNA-binding transcription factor activity
C1701_RS03435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1701_RS03450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1701_RS03490	COG0088	Forms part of the polypeptide exit tunnel
C1701_RS03505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1701_RS03540	COG0124	histidyl-tRNA synthetase
C1701_RS03545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1701_RS03560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1701_RS03570	COG2255	four-way junction helicase activity
C1701_RS03575	COG0632	four-way junction helicase activity
C1701_RS03580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1701_RS03595	COG0217	transcriptional regulatory protein
C1701_RS03610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C1701_RS03615	COG1396	sequence-specific DNA binding
C1701_RS03620	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C1701_RS03635	COG3220	belongs to the UPF0276 family
C1701_RS03645	COG1051	belongs to the nudix hydrolase family
C1701_RS03650	COG0438	transferase activity, transferring glycosyl groups
C1701_RS03655	COG1560	Kdo2-lipid A biosynthetic process
C1701_RS03675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1701_RS03695	COG4946	Tricorn protease homolog
C1701_RS03695	COG0823	Involved in the tonB-independent uptake of proteins
C1701_RS03695	COG1506	peptidase
C1701_RS03705	COG4221	oxidoreductase activity
C1701_RS03755	COG0237	dephospho-CoA kinase activity
C1701_RS03755	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C1701_RS03760	COG0539	negative regulation of cytoplasmic translation
C1701_RS03765	COG2226	methyltransferase
C1701_RS03790	COG2050	protein possibly involved in aromatic compounds catabolism
C1701_RS03800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1701_RS03810	COG0515	serine threonine protein kinase
C1701_RS03810	COG2815	serine threonine protein kinase
C1701_RS03835	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1701_RS03865	COG1946	Acyl-CoA thioesterase
C1701_RS03880	COG2234	aminopeptidase activity
C1701_RS03890	COG0069	glutamate synthase activity
C1701_RS03890	COG0067	glutamate synthase
C1701_RS03890	COG0070	glutamate synthase
C1701_RS03895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1701_RS03900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS03905	COG1120	ATPase activity
C1701_RS03915	COG1252	NADH dehydrogenase
C1701_RS03925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1701_RS03945	COG0686	Belongs to the AlaDH PNT family
C1701_RS03955	COG0494	nUDIX hydrolase
C1701_RS03960	COG0504	CTP synthase activity
C1701_RS03980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1701_RS03995	COG0647	UMP catabolic process
C1701_RS04030	COG2094	Belongs to the DNA glycosylase MPG family
C1701_RS04035	COG0165	Argininosuccinate lyase
C1701_RS04040	COG0137	argininosuccinate synthase activity
C1701_RS04045	COG1438	arginine binding
C1701_RS04055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1701_RS04060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1701_RS04065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1701_RS04070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1701_RS04095	COG0072	phenylalanine-tRNA ligase activity
C1701_RS04095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1701_RS04100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1701_RS04120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1701_RS04125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1701_RS04130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1701_RS04135	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1701_RS04165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1701_RS04210	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C1701_RS04240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C1701_RS04245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS04250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS04270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1701_RS04280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1701_RS04300	COG2267	carboxylic ester hydrolase activity
C1701_RS04320	COG1309	transcriptional regulator
C1701_RS04325	COG2409	Drug exporters of the RND superfamily
C1701_RS04330	COG2186	Transcriptional regulator
C1701_RS04345	COG2376	Dihydroxyacetone kinase
C1701_RS04350	COG0698	ribose 5-phosphate isomerase
C1701_RS04355	COG0149	triose-phosphate isomerase activity
C1701_RS04360	COG1082	Xylose isomerase domain protein TIM barrel
C1701_RS04365	COG2084	Dehydrogenase
C1701_RS04380	COG2080	2 iron, 2 sulfur cluster binding
C1701_RS04385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1701_RS04390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1701_RS04400	COG0738	Major facilitator superfamily
C1701_RS04405	COG3226	Transcriptional regulator
C1701_RS04410	COG0439	Biotin carboxylase
C1701_RS04415	COG0564	pseudouridine synthase activity
C1701_RS04425	COG2197	response regulator
C1701_RS04430	COG3851	Histidine kinase
C1701_RS04440	COG1131	(ABC) transporter
C1701_RS04455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1701_RS04470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS04485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS04540	COG1609	Transcriptional regulator
C1701_RS04545	COG3285	dna ligase
C1701_RS04545	COG1793	dna ligase
C1701_RS04555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C1701_RS04560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1701_RS04565	COG0569	domain protein
C1701_RS04570	COG1937	Protein conserved in bacteria
C1701_RS04600	COG1609	Transcriptional regulator
C1701_RS04625	COG2755	lipolytic protein G-D-S-L family
C1701_RS04630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1701_RS04635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1701_RS04690	COG1793	dna ligase
C1701_RS04710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1701_RS04720	COG3253	May function as heme-dependent peroxidase
C1701_RS04730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1701_RS04740	COG2197	response regulator
C1701_RS04755	COG0183	Belongs to the thiolase family
C1701_RS04760	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1701_RS04760	COG1024	Enoyl-CoA hydratase
C1701_RS04765	COG2205	protein histidine kinase activity
C1701_RS04770	COG0745	RESPONSE REGULATOR receiver
C1701_RS04775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1701_RS04780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1701_RS04800	COG0756	dUTP diphosphatase activity
C1701_RS04820	COG0483	inositol monophosphate 1-phosphatase activity
C1701_RS04825	COG1940	carbohydrate kinase activity
C1701_RS04835	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS04850	COG4214	carbohydrate transport
C1701_RS04860	COG4213	ABC transporter substrate-binding protein
C1701_RS04865	COG2197	response regulator
C1701_RS04870	COG4585	Histidine kinase
C1701_RS04905	COG2313	pseudouridylate synthase activity
C1701_RS04920	COG1490	D-aminoacyl-tRNA deacylase activity
C1701_RS04940	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1701_RS04950	COG2186	Transcriptional regulator
C1701_RS04970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1701_RS04985	COG2936	dipeptidyl-peptidase activity
C1701_RS05025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1701_RS05030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1701_RS05045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1701_RS05060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1701_RS05065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1701_RS05080	COG1196	nuclear chromosome segregation
C1701_RS05090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1701_RS05095	COG1126	abc transporter atp-binding protein
C1701_RS05105	COG4597	amino acid ABC transporter
C1701_RS05110	COG0765	amino acid transport
C1701_RS05115	COG4106	trans-aconitate 2-methyltransferase activity
C1701_RS05125	COG0800	Aldolase
C1701_RS05140	COG2137	regulation of response to DNA damage stimulus
C1701_RS05145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1701_RS05165	COG2814	Major facilitator Superfamily
C1701_RS05170	COG0443	Heat shock 70 kDa protein
C1701_RS05175	COG1201	RNA secondary structure unwinding
C1701_RS05185	COG1063	alcohol dehydrogenase
C1701_RS05200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1701_RS05235	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS05255	COG1414	Transcriptional regulator
C1701_RS05290	COG4585	Histidine kinase
C1701_RS05295	COG2197	response regulator
C1701_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS05325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS05360	COG0142	geranyltranstransferase activity
C1701_RS05380	COG0515	serine threonine protein kinase
C1701_RS05380	COG2815	serine threonine protein kinase
C1701_RS05390	COG2268	Band 7 protein
C1701_RS05410	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS05415	COG0584	glycerophosphoryl diester phosphodiesterase
C1701_RS05430	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1701_RS05460	COG1940	carbohydrate kinase activity
C1701_RS05470	COG0003	Pfam Anion-transporting ATPase
C1701_RS05495	COG0438	transferase activity, transferring glycosyl groups
C1701_RS05505	COG3883	PFAM NLP P60 protein
C1701_RS05505	COG0791	NLP P60 protein
C1701_RS05525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1701_RS05535	COG2010	Cytochrome c
C1701_RS05540	COG1845	cytochrome c oxidase, subunit III
C1701_RS05555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1701_RS05565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1701_RS05605	COG0667	Aldo Keto reductase
C1701_RS05615	COG0477	Major facilitator Superfamily
C1701_RS05630	COG0640	Transcriptional regulator
C1701_RS05645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1701_RS05655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1701_RS05675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1701_RS05680	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1701_RS05690	COG0321	lipoyl(octanoyl) transferase activity
C1701_RS05700	COG4221	oxidoreductase activity
C1701_RS05705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1701_RS05720	COG0174	glutamine synthetase
C1701_RS05735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1701_RS05760	COG0275	rRNA processing
C1701_RS05770	COG0174	glutamine synthetase
C1701_RS05780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1701_RS05780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1701_RS05790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1701_RS05795	COG0435	Glutathione S-transferase
C1701_RS05815	COG0791	NLP P60 protein
C1701_RS05815	COG3883	PFAM NLP P60 protein
C1701_RS05875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1701_RS05885	COG3001	Fructosamine kinase
C1701_RS05895	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1701_RS05925	COG2211	Major facilitator Superfamily
C1701_RS05950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1701_RS06005	COG2239	Acts as a magnesium transporter
C1701_RS06015	COG3201	nicotinamide mononucleotide transporter
C1701_RS06030	COG0667	Aldo Keto reductase
C1701_RS06040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1701_RS06045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1701_RS06075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1701_RS06135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1701_RS06170	COG1254	Belongs to the acylphosphatase family
C1701_RS06175	COG2340	Cysteine-rich secretory protein family
C1701_RS06195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1701_RS06205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1701_RS06225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1701_RS06230	COG0571	ribonuclease III activity
C1701_RS06235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1701_RS06250	COG0456	acetyltransferase
C1701_RS06255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1701_RS06260	COG0742	ribosomal rna small subunit methyltransferase
C1701_RS06270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1701_RS06280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1701_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS06290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1701_RS06335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1701_RS06350	COG0626	cystathionine gamma-synthase activity
C1701_RS06355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1701_RS06365	COG1920	GTP binding
C1701_RS06380	COG0494	nUDIX hydrolase
C1701_RS06380	COG0406	alpha-ribazole phosphatase activity
C1701_RS06385	COG0776	regulation of translation
C1701_RS06390	COG0066	3-isopropylmalate dehydratase activity
C1701_RS06395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1701_RS06425	COG1011	Hydrolase
C1701_RS06440	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1701_RS06445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1701_RS06450	COG0473	3-isopropylmalate dehydrogenase activity
C1701_RS06455	COG1404	Belongs to the peptidase S8 family
C1701_RS06475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1701_RS06480	COG0440	acetolactate synthase activity
C1701_RS06495	COG0129	dihydroxy-acid dehydratase activity
C1701_RS06500	COG2259	Doxx family
C1701_RS06515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1701_RS06530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1701_RS06535	COG0154	amidase activity
C1701_RS06540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1701_RS06555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1701_RS06570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1701_RS06575	COG0482	sulfurtransferase activity
C1701_RS06590	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C1701_RS06625	COG2226	methyltransferase
C1701_RS06640	COG1119	ATPase activity
C1701_RS06715	COG1131	(ABC) transporter
C1701_RS06735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1701_RS06740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1701_RS06745	COG0598	Magnesium transport protein CorA
C1701_RS06750	COG1234	tRNA 3'-trailer cleavage
C1701_RS06755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1701_RS06795	COG3191	aminopeptidase activity
C1701_RS06810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1701_RS06815	COG1335	isochorismatase
C1701_RS06830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS06855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1701_RS06860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1701_RS06865	COG1984	allophanate hydrolase subunit 2
C1701_RS06880	COG2814	Major facilitator Superfamily
C1701_RS06890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1701_RS06920	COG1959	2 iron, 2 sulfur cluster binding
C1701_RS06930	COG0596	Alpha beta hydrolase
C1701_RS06955	COG1349	DNA-binding transcription factor activity
C1701_RS06965	COG1175	transmembrane transport
C1701_RS06970	COG0395	ABC-type sugar transport system, permease component
C1701_RS07035	COG1309	transcriptional regulator
C1701_RS07055	COG0385	Bile acid
C1701_RS07075	COG2197	response regulator
C1701_RS07080	COG4585	Histidine kinase
C1701_RS07095	COG0737	Belongs to the 5'-nucleotidase family
C1701_RS07110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1701_RS07115	COG2177	Part of the ABC transporter FtsEX involved in
C1701_RS07120	COG2884	Cell division ATP-binding protein ftsE
C1701_RS07125	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1701_RS07160	COG1615	UPF0182 protein
C1701_RS07170	COG3480	Lon protease (S16) C-terminal proteolytic domain
C1701_RS07190	COG0515	serine threonine protein kinase
C1701_RS07195	COG0596	Alpha beta hydrolase
C1701_RS07220	COG0612	Peptidase, M16
C1701_RS07225	COG0612	Peptidase, M16
C1701_RS07245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1701_RS07305	COG2267	carboxylic ester hydrolase activity
C1701_RS07325	COG0513	Belongs to the DEAD box helicase family
C1701_RS07430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1701_RS07435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1701_RS07440	COG1643	Atp-dependent helicase
C1701_RS07460	COG2814	Major facilitator Superfamily
C1701_RS07490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1701_RS07505	COG1024	Enoyl-CoA hydratase
C1701_RS07525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1701_RS07530	COG1611	Belongs to the LOG family
C1701_RS07565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1701_RS07570	COG4608	Belongs to the ABC transporter superfamily
C1701_RS07580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS07585	COG0601	transmembrane transport
C1701_RS07590	COG0747	negative chemotaxis
C1701_RS07595	COG0747	negative chemotaxis
C1701_RS07600	COG1217	gtp-binding protein TYPA
C1701_RS07635	COG2205	protein histidine kinase activity
C1701_RS07650	COG1131	(ABC) transporter
C1701_RS07660	COG3842	ATPase activity
C1701_RS07665	COG4149	molybdate abc transporter
C1701_RS07670	COG1840	ABC-type Fe3 transport system, periplasmic component
C1701_RS07680	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1701_RS07685	COG1051	belongs to the nudix hydrolase family
C1701_RS07700	COG0012	GTP binding
C1701_RS07705	COG0419	ATPase involved in DNA repair
C1701_RS07710	COG0420	3'-5' exonuclease activity
C1701_RS07715	COG1322	Protein conserved in bacteria
C1701_RS07725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1701_RS07745	COG1722	exodeoxyribonuclease VII activity
C1701_RS07770	COG0492	ferredoxin-NADP+ reductase activity
C1701_RS07775	COG0114	fumarate hydratase activity
C1701_RS07805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1701_RS07830	COG1331	Highly conserved protein containing a thioredoxin domain
C1701_RS07845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1701_RS07855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1701_RS07865	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C1701_RS07870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1701_RS07895	COG2755	lipolytic protein G-D-S-L family
C1701_RS07900	COG0183	Belongs to the thiolase family
C1701_RS07920	COG2133	pyrroloquinoline quinone binding
C1701_RS07930	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C1701_RS07945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1701_RS07965	COG1252	NADH dehydrogenase
C1701_RS07990	COG4608	Belongs to the ABC transporter superfamily
C1701_RS08000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS08005	COG0601	transmembrane transport
C1701_RS08010	COG0747	negative chemotaxis
C1701_RS08035	COG0148	phosphopyruvate hydratase activity
C1701_RS08055	COG4946	Tricorn protease homolog
C1701_RS08055	COG0793	Belongs to the peptidase S41A family
C1701_RS08080	COG2133	pyrroloquinoline quinone binding
C1701_RS08085	COG1309	transcriptional regulator
C1701_RS08130	COG0577	efflux transmembrane transporter activity
C1701_RS08130	COG1136	(ABC) transporter
C1701_RS08145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1701_RS08155	COG0193	aminoacyl-tRNA hydrolase activity
C1701_RS08175	COG0488	(ABC) transporter
C1701_RS08185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1701_RS08190	COG1464	Belongs to the NlpA lipoprotein family
C1701_RS08195	COG2011	ABC-type metal ion transport system permease component
C1701_RS08200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1701_RS08205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1701_RS08215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1701_RS08220	COG1652	LysM domain
C1701_RS08225	COG0084	hydrolase, TatD family'
C1701_RS08230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1701_RS08280	COG1131	(ABC) transporter
C1701_RS08285	COG2188	Transcriptional regulator
C1701_RS08305	COG0583	DNA-binding transcription factor activity
C1701_RS08310	COG0384	phenazine biosynthesis protein PhzF
C1701_RS08335	COG1120	ATPase activity
C1701_RS08345	COG0477	Major facilitator Superfamily
C1701_RS08365	COG0018	arginyl-trna synthetase
C1701_RS08380	COG1131	(ABC) transporter
C1701_RS08390	COG4585	Histidine kinase
C1701_RS08395	COG2197	response regulator
C1701_RS08415	COG0515	serine threonine protein kinase
C1701_RS08415	COG2815	serine threonine protein kinase
C1701_RS08450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1701_RS08460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1701_RS08465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1701_RS08480	COG1970	mechanosensitive ion channel activity
C1701_RS08495	COG0315	cyclic pyranopterin monophosphate synthase activity
C1701_RS08495	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1701_RS08500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1701_RS08510	COG2205	protein histidine kinase activity
C1701_RS08515	COG0745	RESPONSE REGULATOR receiver
C1701_RS08540	COG0604	alcohol dehydrogenase
C1701_RS08605	COG1674	ftsk spoiiie
C1701_RS08620	COG2130	NADP-dependent
C1701_RS08625	COG0702	epimerase
C1701_RS08630	COG3631	Ketosteroid isomerase-related protein
C1701_RS08650	COG4152	abc transporter atp-binding protein
C1701_RS08670	COG1228	amidohydrolase
C1701_RS08675	COG2017	converts alpha-aldose to the beta-anomer
C1701_RS08680	COG0531	amino acid
C1701_RS08685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1701_RS08700	COG0259	pyridoxamine-phosphate oxidase activity
C1701_RS08725	COG1132	(ABC) transporter
C1701_RS08735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1701_RS08745	COG2814	Major facilitator Superfamily
C1701_RS08765	COG2252	PERMEase
C1701_RS08790	COG1309	transcriptional regulator
C1701_RS08800	COG2814	Major facilitator Superfamily
C1701_RS08810	COG1278	Cold shock
C1701_RS08820	COG1309	transcriptional regulator
C1701_RS08825	COG0384	phenazine biosynthesis protein PhzF
C1701_RS08845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1701_RS08870	COG1652	LysM domain
C1701_RS08890	COG0314	molybdopterin synthase activity
C1701_RS08930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1701_RS08930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1701_RS08945	COG2018	Roadblock/LC7 domain
C1701_RS08955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1701_RS08960	COG1174	glycine betaine transport
C1701_RS08965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1701_RS08970	COG1116	anion transmembrane transporter activity
C1701_RS08975	COG1061	Type III restriction enzyme res subunit
C1701_RS08980	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS09005	COG0459	protein refolding
C1701_RS09030	COG0688	phosphatidylethanolamine metabolic process
C1701_RS09040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1701_RS09045	COG0167	dihydroorotate dehydrogenase activity
C1701_RS09055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1701_RS09060	COG2188	Transcriptional regulator
C1701_RS09085	COG0352	thiamine-phosphate diphosphorylase activity
C1701_RS09100	COG2022	thiamine diphosphate biosynthetic process
C1701_RS09110	COG0351	phosphomethylpyrimidine kinase
C1701_RS09115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1701_RS09120	COG0242	peptide deformylase activity
C1701_RS09145	COG3903	Transcriptional regulator
C1701_RS09145	COG3629	intracellular signal transduction
C1701_RS09155	COG5285	phytanoyl-CoA dioxygenase
C1701_RS09160	COG1917	Cupin 2, conserved barrel domain protein
C1701_RS09165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1701_RS09170	COG0456	acetyltransferase
C1701_RS09185	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C1701_RS09190	COG3387	PFAM Glycoside hydrolase 15-related
C1701_RS09200	COG1609	Transcriptional regulator
C1701_RS09210	COG1653	transport
C1701_RS09220	COG3833	ABC-type maltose transport systems, permease component
C1701_RS09225	COG3842	ATPase activity
C1701_RS09235	COG1121	(ABC) transporter
C1701_RS09240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1701_RS09310	COG0215	cysteine-tRNA ligase activity
C1701_RS09325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1701_RS09330	COG1329	Transcriptional regulator
C1701_RS09340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1701_RS09355	COG1194	a g-specific adenine glycosylase
C1701_RS09370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1701_RS09400	COG1120	ATPase activity
C1701_RS09410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1701_RS09420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1701_RS09425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1701_RS09430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1701_RS09450	COG0649	NAD binding
C1701_RS09470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1701_RS09475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1701_RS09480	COG0302	gtp cyclohydrolase
C1701_RS09485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1701_RS09495	COG0037	tRNA processing
C1701_RS09505	COG2027	D-alanyl-D-alanine carboxypeptidase
C1701_RS09510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1701_RS09570	COG0470	DNA polymerase III
C1701_RS09575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1701_RS09585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1701_RS09585	COG1754	DNA topoisomerase type I activity
C1701_RS09590	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C1701_RS09595	COG1111	helicase
C1701_RS09595	COG1205	dead DEAH box helicase
C1701_RS09645	COG1472	Belongs to the glycosyl hydrolase 3 family
C1701_RS09650	COG3876	Protein conserved in bacteria
C1701_RS09655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1701_RS09660	COG1737	Transcriptional regulator
C1701_RS09665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1701_RS09670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1701_RS09680	COG0730	response to heat
C1701_RS09690	COG0596	Alpha beta hydrolase
C1701_RS09785	COG0003	Pfam Anion-transporting ATPase
C1701_RS09795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1701_RS09795	COG4499	WXG100 protein secretion system (Wss), protein YukC
C1701_RS09805	COG1408	metallophosphoesterase
C1701_RS09830	COG1764	response to oxidative stress
C1701_RS09835	COG0431	NADPH-dependent FMN reductase
C1701_RS09860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1701_RS09890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1701_RS09905	COG0640	Transcriptional regulator
C1701_RS09920	COG4608	Belongs to the ABC transporter superfamily
C1701_RS09925	COG0444	Belongs to the ABC transporter superfamily
C1701_RS09930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS09935	COG0601	transmembrane transport
C1701_RS09940	COG0747	negative chemotaxis
C1701_RS09950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1701_RS09955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1701_RS10005	COG0590	tRNA wobble adenosine to inosine editing
C1701_RS10015	COG0287	Prephenate dehydrogenase
C1701_RS10020	COG0183	Belongs to the thiolase family
C1701_RS10045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1701_RS10055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1701_RS10070	COG1846	Transcriptional regulator
C1701_RS10075	COG2234	aminopeptidase activity
C1701_RS10110	COG1216	Glycosyl transferase, family 2
C1701_RS10120	COG1216	Glycosyl transferase, family 2
C1701_RS10130	COG0579	oxidoreductase
C1701_RS10135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1701_RS10155	COG0656	L-ascorbic acid biosynthetic process
C1701_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS10210	COG0463	Glycosyl transferase, family 2
C1701_RS10220	COG0561	phosphatase activity
C1701_RS10225	COG3591	Belongs to the peptidase S1B family
C1701_RS10230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS10250	COG3766	membrane
C1701_RS10255	COG0754	glutathionylspermidine amidase activity
C1701_RS10275	COG0406	alpha-ribazole phosphatase activity
C1701_RS10285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C1701_RS10300	COG1309	transcriptional regulator
C1701_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS10320	COG4988	ABC transporter
C1701_RS10325	COG1294	oxidase, subunit
C1701_RS10330	COG1271	oxidase subunit
C1701_RS10360	COG0587	DNA-directed DNA polymerase activity
C1701_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS10405	COG2235	arginine
C1701_RS10415	COG1528	Iron-storage protein
C1701_RS10455	COG1515	deoxyribonuclease V activity
C1701_RS10460	COG0653	protein targeting
C1701_RS10495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1701_RS10505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1701_RS10520	COG0425	Belongs to the sulfur carrier protein TusA family
C1701_RS10520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1701_RS10530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1701_RS10575	COG2226	methyltransferase
C1701_RS10600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1701_RS10605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1701_RS10640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1701_RS10650	COG0667	Aldo Keto reductase
C1701_RS10660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS10670	COG1595	DNA-templated transcription, initiation
C1701_RS10710	COG1174	glycine betaine transport
C1701_RS10720	COG1174	glycine betaine transport
C1701_RS10765	COG1309	transcriptional regulator
C1701_RS10795	COG1716	ATPase activity
C1701_RS10800	COG1716	ATPase activity
C1701_RS10815	COG0768	penicillin binding
C1701_RS10820	COG0515	serine threonine protein kinase
C1701_RS10825	COG0515	serine threonine protein kinase
C1701_RS10825	COG2815	serine threonine protein kinase
C1701_RS10845	COG3764	Sortase (surface protein transpeptidase)
C1701_RS10865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1701_RS10890	COG0702	epimerase
C1701_RS10915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1701_RS10920	COG0187	DNA topoisomerase II activity
C1701_RS10925	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C1701_RS10930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1701_RS10935	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C1701_RS10945	COG0592	DNA-directed DNA polymerase activity
C1701_RS10950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1701_RS10955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1701_RS10965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1701_RS10970	COG0706	membrane insertase activity
C1701_RS10985	COG0357	Ribosomal RNA small subunit methyltransferase G
C1701_RS10990	COG1192	Involved in chromosome partitioning
C1701_RS11000	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1701_RS11005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1701_RS11015	COG3409	Peptidoglycan-binding domain 1 protein
C1701_RS11015	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1701_RS11035	COG1595	DNA-templated transcription, initiation
C1701_RS11040	COG0515	serine threonine protein kinase
C1701_RS11040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1701_RS11060	COG0617	tRNA 3'-terminal CCA addition
C1701_RS11075	COG1678	Uncharacterized ACR, COG1678
C1701_RS11085	COG0495	leucyl-tRNA aminoacylation
C1701_RS11110	COG2197	response regulator
C1701_RS11115	COG2205	protein histidine kinase activity
C1701_RS11155	COG1595	DNA-templated transcription, initiation
C1701_RS11180	COG0359	binds to the 23S rRNA
C1701_RS11185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1701_RS11235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1701_RS11255	COG1260	myo-inositol-1-phosphate synthase
C1701_RS11280	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1701_RS11285	COG0022	dehydrogenase e1 component
C1701_RS11300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1701_RS11310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1701_RS11315	COG0765	amino acid transport
C1701_RS11320	COG1126	abc transporter atp-binding protein
C1701_RS11335	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1701_RS11365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1701_RS11390	COG1309	transcriptional regulator
C1701_RS11395	COG0477	Major facilitator Superfamily
C1701_RS11435	COG0443	Heat shock 70 kDa protein
C1701_RS11440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1701_RS11465	COG1136	(ABC) transporter
C1701_RS11475	COG2197	response regulator
C1701_RS11485	COG2181	nitrate reductase activity
C1701_RS11485	COG0247	lactate metabolic process
C1701_RS11490	COG2076	Multidrug Resistance protein
C1701_RS11560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS11580	COG3973	AAA domain
C1701_RS11590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1701_RS11600	COG2076	Multidrug Resistance protein
C1701_RS11615	COG1595	DNA-templated transcription, initiation
C1701_RS11625	COG0436	Aminotransferase
C1701_RS11630	COG0454	-acetyltransferase
C1701_RS11650	COG1276	copper resistance
C1701_RS11650	COG2372	response to copper ion
C1701_RS11710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1701_RS11720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1701_RS11730	COG0789	Transcriptional regulator
C1701_RS11735	COG0484	heat shock protein binding
C1701_RS11745	COG0443	Heat shock 70 kDa protein
C1701_RS11780	COG0717	Belongs to the dCTP deaminase family
C1701_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1701_RS11795	COG0028	Belongs to the TPP enzyme family
C1701_RS11800	COG0477	Major facilitator Superfamily
C1701_RS11805	COG1960	acyl-CoA dehydrogenase activity
C1701_RS11845	COG1115	amino acid carrier protein
C1701_RS11850	COG0471	metal ion transport
C1701_RS11855	COG0542	response to heat
C1701_RS11865	COG4221	oxidoreductase activity
C1701_RS11870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1701_RS11875	COG1704	LemA family
C1701_RS11880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1701_RS11890	COG0277	FAD linked oxidase domain protein
C1701_RS11935	COG4129	membrane
C1701_RS11960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1701_RS12000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1701_RS12020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1701_RS12040	COG1733	regulation of RNA biosynthetic process
C1701_RS12055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1701_RS12060	COG0047	phosphoribosylformylglycinamidine synthase activity
C1701_RS12065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1701_RS12085	COG3387	PFAM Glycoside hydrolase 15-related
C1701_RS12100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1701_RS12125	COG3246	L-lysine catabolic process to acetate
C1701_RS12130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1701_RS12145	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C1701_RS12180	COG0745	RESPONSE REGULATOR receiver
C1701_RS12185	COG0456	acetyltransferase
C1701_RS12205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1701_RS12215	COG0704	Plays a role in the regulation of phosphate uptake
C1701_RS12220	COG1316	TRANSCRIPTIONal
C1701_RS12280	COG2197	response regulator
C1701_RS12285	COG4585	Histidine kinase
C1701_RS12325	COG2115	Belongs to the xylose isomerase family
C1701_RS12330	COG1063	alcohol dehydrogenase
C1701_RS12335	COG1070	Carbohydrate kinase
C1701_RS12340	COG0673	inositol 2-dehydrogenase activity
C1701_RS12375	COG1316	TRANSCRIPTIONal
C1701_RS12410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1701_RS12420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1701_RS12445	COG1216	Glycosyl transferase, family 2
C1701_RS12445	COG0438	transferase activity, transferring glycosyl groups
C1701_RS12465	COG0463	Glycosyl transferase, family 2
C1701_RS12470	COG2244	polysaccharide biosynthetic process
C1701_RS12490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C1701_RS12510	COG1404	Belongs to the peptidase S8 family
C1701_RS12535	COG2733	membrane
C1701_RS12555	COG1609	Transcriptional regulator
C1701_RS12595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1701_RS12600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1701_RS12630	COG0788	formyltetrahydrofolate deformylase activity
C1701_RS12645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1701_RS12670	COG0438	transferase activity, transferring glycosyl groups
C1701_RS12680	COG0588	phosphoglycerate mutase activity
C1701_RS12685	COG5002	protein histidine kinase activity
C1701_RS12740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1701_RS12750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1701_RS12780	COG1595	DNA-templated transcription, initiation
C1701_RS12785	COG1960	acyl-CoA dehydrogenase activity
C1701_RS12800	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C1701_RS12805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1701_RS12810	COG0181	hydroxymethylbilane synthase activity
C1701_RS12815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1701_RS12815	COG1587	Uroporphyrinogen-III synthase
C1701_RS12840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1701_RS12845	COG0406	alpha-ribazole phosphatase activity
C1701_RS12850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1701_RS12855	COG0785	Cytochrome C biogenesis protein
C1701_RS12860	COG1333	cytochrome c biogenesis protein
C1701_RS12865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1701_RS12885	COG1522	sequence-specific DNA binding
C1701_RS12900	COG0242	peptide deformylase activity
C1701_RS12920	COG0586	Pfam SNARE associated Golgi protein
C1701_RS12930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1701_RS12935	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1701_RS12960	COG2226	methyltransferase
C1701_RS12965	COG0644	oxidoreductase
C1701_RS12975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1701_RS12980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1701_RS12985	COG0649	NAD binding
C1701_RS12995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1701_RS13000	COG1034	ATP synthesis coupled electron transport
C1701_RS13005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1701_RS13010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1701_RS13020	COG0713	ATP synthesis coupled electron transport
C1701_RS13035	COG1007	ATP synthesis coupled electron transport
C1701_RS13040	COG0142	geranyltranstransferase activity
C1701_RS13060	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1701_RS13065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1701_RS13065	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1701_RS13070	COG1522	sequence-specific DNA binding
C1701_RS13075	COG1834	amidinotransferase
C1701_RS13090	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1701_RS13100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1701_RS13105	COG0501	Belongs to the peptidase M48B family
C1701_RS13110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1701_RS13115	COG1666	GTP binding
C1701_RS13130	COG1063	alcohol dehydrogenase
C1701_RS13150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1701_RS13155	COG2030	dehydratase
C1701_RS13165	COG0436	Aminotransferase
C1701_RS13175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1701_RS13185	COG0081	regulation of translation
C1701_RS13200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1701_RS13205	COG0222	ribosome binding
C1701_RS13210	COG0085	RNA polymerase activity
C1701_RS13215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1701_RS13220	COG4585	Histidine kinase
C1701_RS13225	COG2197	response regulator
C1701_RS13230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1701_RS13235	COG0049	tRNA binding
C1701_RS13240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1701_RS13245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1701_RS13250	COG0051	transcription antitermination factor activity, RNA binding
C1701_RS13255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1701_RS13260	COG0088	Forms part of the polypeptide exit tunnel
C1701_RS13265	COG0089	rRNA binding
C1701_RS13270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1701_RS13275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1701_RS13280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1701_RS13285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1701_RS13290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1701_RS13295	COG0255	Belongs to the universal ribosomal protein uL29 family
C1701_RS13300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1701_RS13305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1701_RS13310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1701_RS13315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1701_RS13320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1701_RS13325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1701_RS13330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1701_RS13335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1701_RS13340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1701_RS13345	COG1841	ribosomal large subunit assembly
C1701_RS13360	COG0563	adenylate kinase activity
C1701_RS13380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1701_RS13385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1701_RS13390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1701_RS13395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1701_RS13400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1701_RS13405	COG0202	RNA polymerase activity
C1701_RS13410	COG0203	ribosomal protein L17
C1701_RS13415	COG0101	tRNA pseudouridine synthase activity
C1701_RS13425	COG0477	Major facilitator Superfamily
C1701_RS13430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1701_RS13435	COG1819	glycosyl
C1701_RS13470	COG1063	alcohol dehydrogenase
C1701_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS13480	COG2610	gluconate transmembrane transporter activity
C1701_RS13485	COG3265	gluconokinase activity
C1701_RS13495	COG1404	Belongs to the peptidase S8 family
C1701_RS13505	COG1674	ftsk spoiiie
C1701_RS13510	COG0443	Heat shock 70 kDa protein
C1701_RS13530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1701_RS13535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1701_RS13540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1701_RS13575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1701_RS13600	COG0402	S-adenosylhomocysteine deaminase activity
C1701_RS13605	COG4585	Histidine kinase
C1701_RS13610	COG2197	response regulator
C1701_RS13625	COG0456	acetyltransferase
C1701_RS13625	COG1214	PFAM Peptidase M22, glycoprotease
C1701_RS13630	COG0456	acetyltransferase
C1701_RS13635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1701_RS13640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1701_RS13645	COG0459	protein refolding
C1701_RS13685	COG0516	GMP reductase activity
C1701_RS13690	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS13715	COG0515	serine threonine protein kinase
C1701_RS13760	COG0739	heme binding
C1701_RS13770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1701_RS13775	COG0045	succinate-CoA ligase (ADP-forming) activity
C1701_RS13820	COG1309	transcriptional regulator
C1701_RS13825	COG1131	(ABC) transporter
C1701_RS13830	COG3559	Exporter of polyketide antibiotics
C1701_RS13840	COG0745	RESPONSE REGULATOR receiver
C1701_RS13845	COG2205	protein histidine kinase activity
C1701_RS13855	COG2124	cytochrome p450
C1701_RS13905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1701_RS13915	COG0604	alcohol dehydrogenase
C1701_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS13915	COG3321	synthase
C1701_RS13925	COG0039	L-malate dehydrogenase activity
C1701_RS13960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS13965	COG0708	Exodeoxyribonuclease III
C1701_RS14015	COG1295	ribonuclease BN
C1701_RS14060	COG1295	ribonuclease BN
C1701_RS14065	COG1686	Belongs to the peptidase S11 family
C1701_RS14085	COG2009	succinate dehydrogenase
C1701_RS14090	COG1744	ABC transporter substrate-binding protein PnrA-like
C1701_RS14100	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1701_RS14105	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1701_RS14150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1701_RS14170	COG0791	NLP P60 protein
C1701_RS14170	COG3883	PFAM NLP P60 protein
C1701_RS14185	COG1131	(ABC) transporter
C1701_RS14205	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS14210	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS14215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1701_RS14220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1701_RS14230	COG1320	monovalent cation:proton antiporter activity
C1701_RS14235	COG2212	antiporter activity
C1701_RS14245	COG0651	ATP synthesis coupled electron transport
C1701_RS14250	COG1006	Multisubunit Na H antiporter MnhC subunit
C1701_RS14255	COG2111	Na H antiporter
C1701_RS14260	COG2111	Na H antiporter
C1701_RS14260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1701_RS14265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1701_RS14265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1701_RS14280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1701_RS14285	COG3645	SOS response
C1701_RS14295	COG1940	carbohydrate kinase activity
C1701_RS14310	COG1129	ABC transporter
C1701_RS14315	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1701_RS14320	COG1879	ABC-type sugar transport system periplasmic component
C1701_RS14340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1701_RS14385	COG1473	amidohydrolase
C1701_RS14385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1701_RS14400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1701_RS14405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1701_RS14410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1701_RS14455	COG4770	biotin carboxylase activity
C1701_RS14460	COG1301	dicarboxylic acid transport
C1701_RS14470	COG0424	maF-like protein
C1701_RS14480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1701_RS14520	COG0483	inositol monophosphate 1-phosphatase activity
C1701_RS14525	COG0745	RESPONSE REGULATOR receiver
C1701_RS14530	COG2205	protein histidine kinase activity
C1701_RS14570	COG1316	TRANSCRIPTIONal
C1701_RS14575	COG1316	TRANSCRIPTIONal
C1701_RS14585	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1701_RS14595	COG0438	transferase activity, transferring glycosyl groups
C1701_RS14645	COG0438	transferase activity, transferring glycosyl groups
C1701_RS14675	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C1701_RS14675	COG0778	Nitroreductase
C1701_RS14710	COG1663	tetraacyldisaccharide 4'-kinase activity
C1701_RS14710	COG2835	tetraacyldisaccharide 4'-kinase activity
C1701_RS14720	COG1482	cell wall glycoprotein biosynthetic process
C1701_RS14730	COG0531	amino acid
C1701_RS14740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1701_RS14755	COG0745	RESPONSE REGULATOR receiver
C1701_RS14760	COG5002	protein histidine kinase activity
C1701_RS14760	COG5000	phosphorelay sensor kinase activity
C1701_RS14765	COG5401	PFAM Sporulation and spore germination
C1701_RS14775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1701_RS14780	COG0653	protein targeting
C1701_RS14790	COG1011	Hydrolase
C1701_RS14795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1701_RS14825	COG1162	GTPase activity
C1701_RS14830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1701_RS14835	COG2135	peptidase activity
C1701_RS14840	COG2135	peptidase activity
C1701_RS14850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1701_RS14855	COG1595	DNA-templated transcription, initiation
C1701_RS14860	COG5662	AntiSigma factor
C1701_RS14865	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1701_RS14900	COG0588	phosphoglycerate mutase activity
C1701_RS14905	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C1701_RS14915	COG5001	Diguanylate cyclase
C1701_RS14930	COG1174	glycine betaine transport
C1701_RS14960	COG2986	histidine ammonia-lyase
C1701_RS14965	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1701_RS14980	COG1228	amidohydrolase
C1701_RS15000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS15010	COG2197	response regulator
C1701_RS15140	COG2860	membrane
C1701_RS15165	COG2318	DinB family
C1701_RS15170	COG0515	serine threonine protein kinase
C1701_RS15195	COG2018	Roadblock/LC7 domain
C1701_RS15200	COG3850	Histidine kinase
C1701_RS15200	COG5002	protein histidine kinase activity
C1701_RS15215	COG2217	Heavy metal translocating P-type atpase
C1701_RS15240	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1701_RS15280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1701_RS15285	COG1278	Cold shock
C1701_RS15300	COG0655	NAD(P)H dehydrogenase (quinone) activity
C1701_RS15350	COG2183	response to ionizing radiation
C1701_RS15375	COG2017	converts alpha-aldose to the beta-anomer
C1701_RS15385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS15400	COG1404	Belongs to the peptidase S8 family
C1701_RS15450	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C1701_RS15500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS15525	COG0475	glutathione-regulated potassium exporter activity
C1701_RS15540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1701_RS15545	COG3251	PFAM MbtH domain protein
C1701_RS15550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1701_RS15645	COG1404	Belongs to the peptidase S8 family
C1701_RS15670	COG2267	carboxylic ester hydrolase activity
C1701_RS15735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS15785	COG2072	flavoprotein involved in K transport
C1701_RS15790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS15795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS15800	COG1120	ATPase activity
C1701_RS15815	COG1132	(ABC) transporter
C1701_RS15845	COG1309	transcriptional regulator
C1701_RS15880	COG0789	Transcriptional regulator
C1701_RS15890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1701_RS15905	COG0450	alkyl hydroperoxide reductase
C1701_RS15910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1701_RS15915	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1701_RS15920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1701_RS15925	COG0745	RESPONSE REGULATOR receiver
C1701_RS15930	COG2205	protein histidine kinase activity
C1701_RS15950	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS15955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1701_RS15960	COG1090	epimerase
C1701_RS15965	COG0673	inositol 2-dehydrogenase activity
C1701_RS15975	COG1175	transmembrane transport
C1701_RS15980	COG0395	ABC-type sugar transport system, permease component
C1701_RS16000	COG3866	Pectate lyase
C1701_RS16010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1701_RS16035	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1701_RS16035	COG1672	PFAM Archaeal ATPase
C1701_RS16075	COG1070	Carbohydrate kinase
C1701_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS16085	COG3347	Dehydrogenase
C1701_RS16090	COG4952	isomerase
C1701_RS16095	COG3254	rhamnose metabolic process
C1701_RS16100	COG1609	Transcriptional regulator
C1701_RS16115	COG0673	inositol 2-dehydrogenase activity
C1701_RS16160	COG0318	PFAM AMP-dependent synthetase and ligase
C1701_RS16175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1701_RS16200	COG1376	ErfK ybiS ycfS ynhG family protein
C1701_RS16215	COG3629	intracellular signal transduction
C1701_RS16215	COG3903	Transcriptional regulator
C1701_RS16225	COG2315	Protein conserved in bacteria
C1701_RS16240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1701_RS16275	COG2197	response regulator
C1701_RS16315	COG0484	heat shock protein binding
C1701_RS16365	COG1309	transcriptional regulator
C1701_RS16370	COG1024	Enoyl-CoA hydratase
C1701_RS16375	COG0318	PFAM AMP-dependent synthetase and ligase
C1701_RS16400	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1701_RS16400	COG0596	Alpha beta hydrolase
C1701_RS16415	COG1960	acyl-CoA dehydrogenase activity
C1701_RS16425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1701_RS16460	COG0183	Belongs to the thiolase family
C1701_RS16505	COG1132	(ABC) transporter
C1701_RS16510	COG0567	Dehydrogenase, E1 component
C1701_RS16510	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1701_RS16560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1701_RS16620	COG1115	amino acid carrier protein
C1701_RS16800	COG2197	response regulator
C1701_RS16810	COG0300	oxidoreductase activity
C1701_RS16815	COG0583	DNA-binding transcription factor activity
C1701_RS16830	COG0300	oxidoreductase activity
C1701_RS16860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1701_RS16870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1701_RS16955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1701_RS17065	COG1131	(ABC) transporter
C1701_RS17170	COG2201	protein-glutamate methylesterase activity
C1701_RS17180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1701_RS17190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1701_RS17205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS17205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS17210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1701_RS17215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1701_RS17295	COG1404	Belongs to the peptidase S8 family
C1701_RS17300	COG1404	Belongs to the peptidase S8 family
C1701_RS17325	COG2814	Major facilitator Superfamily
C1701_RS17330	COG2814	Major facilitator Superfamily
C1701_RS17345	COG0473	3-isopropylmalate dehydrogenase activity
C1701_RS17365	COG2828	Protein conserved in bacteria
C1701_RS17370	COG0778	Nitroreductase
C1701_RS17375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1701_RS17385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1701_RS17395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1701_RS17400	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C1701_RS17405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1701_RS17405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1701_RS17425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1701_RS17450	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1701_RS17455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1701_RS17460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1701_RS17495	COG1320	monovalent cation:proton antiporter activity
C1701_RS17500	COG2212	antiporter activity
C1701_RS17505	COG1863	multisubunit Na H antiporter MnhE subunit
C1701_RS17510	COG0651	ATP synthesis coupled electron transport
C1701_RS17515	COG1006	Multisubunit Na H antiporter MnhC subunit
C1701_RS17520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1701_RS17520	COG2111	Na H antiporter
C1701_RS17535	COG1733	regulation of RNA biosynthetic process
C1701_RS17570	COG0018	arginyl-trna synthetase
C1701_RS17575	COG0019	diaminopimelate decarboxylase activity
C1701_RS17580	COG0460	homoserine dehydrogenase
C1701_RS17585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1701_RS17590	COG0083	homoserine kinase activity
C1701_RS17605	COG0254	rRNA binding
C1701_RS17615	COG2890	protein-(glutamine-N5) methyltransferase activity
C1701_RS17630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1701_RS17635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1701_RS17650	COG0356	it plays a direct role in the translocation of protons across the membrane
C1701_RS17655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1701_RS17660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1701_RS17665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1701_RS17670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1701_RS17675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1701_RS17680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1701_RS17700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1701_RS17725	COG0765	amino acid transport
C1701_RS17730	COG0765	amino acid transport
C1701_RS17735	COG1126	abc transporter atp-binding protein
C1701_RS17740	COG0494	nUDIX hydrolase
C1701_RS17750	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C1701_RS17780	COG2376	Dihydroxyacetone kinase
C1701_RS17835	COG0346	lactoylglutathione lyase activity
C1701_RS17845	COG0183	Belongs to the thiolase family
C1701_RS17860	COG1609	Transcriptional regulator
C1701_RS17870	COG1846	Transcriptional regulator
C1701_RS17880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1701_RS17880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1701_RS17910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1701_RS17920	COG5297	Belongs to the glycosyl hydrolase family 6
C1701_RS17920	COG4733	cellulase activity
C1701_RS17940	COG0395	ABC-type sugar transport system, permease component
C1701_RS17960	COG1129	ABC transporter
C1701_RS17965	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1701_RS17970	COG0473	3-isopropylmalate dehydrogenase activity
C1701_RS18025	COG2367	Beta-lactamase
C1701_RS18030	COG2223	nitrite transmembrane transporter activity
C1701_RS18035	COG0243	molybdopterin cofactor binding
C1701_RS18040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1701_RS18045	COG2146	nitrite reductase [NAD(P)H] activity
C1701_RS18045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1701_RS18050	COG2146	nitrite reductase [NAD(P)H] activity
C1701_RS18050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1701_RS18060	COG2197	response regulator
C1701_RS18065	COG3629	intracellular signal transduction
C1701_RS18075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C1701_RS18095	COG1595	DNA-templated transcription, initiation
C1701_RS18100	COG1846	Transcriptional regulator
C1701_RS18145	COG1132	(ABC) transporter
C1701_RS18170	COG1131	(ABC) transporter
C1701_RS18190	COG0243	molybdopterin cofactor binding
C1701_RS18225	COG2902	Dehydrogenase
C1701_RS18240	COG0366	Alpha amylase catalytic
C1701_RS18250	COG0668	transmembrane transport
C1701_RS18255	COG3340	Belongs to the peptidase S51 family
C1701_RS18270	COG4126	flavin adenine dinucleotide binding
C1701_RS18300	COG1505	serine-type exopeptidase activity
C1701_RS18320	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C1701_RS18330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1701_RS18350	COG0698	ribose 5-phosphate isomerase
C1701_RS18365	COG4552	Acetyltransferase involved in intracellular survival and related
C1701_RS18460	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1701_RS18465	COG0740	serine-type endopeptidase activity
C1701_RS18470	COG0740	serine-type endopeptidase activity
C1701_RS18475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1701_RS18495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1701_RS18550	COG0525	valine-tRNA ligase activity
C1701_RS18555	COG0285	dihydrofolate synthase activity
C1701_RS18565	COG1131	(ABC) transporter
C1701_RS18585	COG0105	UTP biosynthetic process
C1701_RS18590	COG0456	acetyltransferase
C1701_RS18595	COG1131	(ABC) transporter
C1701_RS18625	COG1530	ribonuclease E activity
C1701_RS18625	COG1530	ribonuclease E activity
C1701_RS18630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1701_RS18640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1701_RS18660	COG0514	ATP-dependent DNA helicase (RecQ)
C1701_RS18665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1701_RS18670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1701_RS18675	COG0799	negative regulation of ribosome biogenesis
C1701_RS18685	COG1307	EDD domain protein, DegV family
C1701_RS18705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1701_RS18715	COG0268	Binds directly to 16S ribosomal RNA
C1701_RS18730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1701_RS18760	COG0481	GTPase activity
C1701_RS18775	COG2258	MOSC domain
C1701_RS18790	COG1024	Enoyl-CoA hydratase
C1701_RS18845	COG1420	regulation of RNA biosynthetic process
C1701_RS18850	COG0484	heat shock protein binding
C1701_RS18860	COG0537	adenosine 5'-monophosphoramidase activity
C1701_RS18870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1701_RS18900	COG0640	Transcriptional regulator
C1701_RS18905	COG0798	PFAM Bile acid sodium symporter
C1701_RS18910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1701_RS18920	COG1381	Involved in DNA repair and RecF pathway recombination
C1701_RS18925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1701_RS18935	COG0701	Predicted permease
C1701_RS18975	COG0423	glycine-tRNA ligase activity
C1701_RS18980	COG3340	Belongs to the peptidase S51 family
C1701_RS18995	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1701_RS19005	COG0358	DNA primase activity
C1701_RS19020	COG4106	trans-aconitate 2-methyltransferase activity
C1701_RS19030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1701_RS19030	COG2070	2-Nitropropane dioxygenase
C1701_RS19040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1701_RS19070	COG4412	M6 family metalloprotease domain protein
C1701_RS19070	COG1404	Belongs to the peptidase S8 family
C1701_RS19080	COG0437	4 iron, 4 sulfur cluster binding
C1701_RS19085	COG3383	formate dehydrogenase (NAD+) activity
C1701_RS19085	COG0243	molybdopterin cofactor binding
C1701_RS19110	COG1136	(ABC) transporter
C1701_RS19115	COG2132	Multicopper oxidase
C1701_RS19125	COG2197	response regulator
C1701_RS19130	COG4585	Histidine kinase
C1701_RS19140	COG2132	Multicopper oxidase
C1701_RS19155	COG1733	regulation of RNA biosynthetic process
C1701_RS19160	COG1115	amino acid carrier protein
C1701_RS19165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1701_RS19190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1701_RS19210	COG0596	Alpha beta hydrolase
C1701_RS19285	COG1660	Displays ATPase and GTPase activities
C1701_RS19290	COG2205	protein histidine kinase activity
C1701_RS19295	COG0745	RESPONSE REGULATOR receiver
C1701_RS19310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1701_RS19340	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS19370	COG0228	four-way junction DNA binding
C1701_RS19380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1701_RS19385	COG0336	Belongs to the RNA methyltransferase TrmD family
C1701_RS19390	COG0335	large ribosomal subunit rRNA binding
C1701_RS19395	COG0681	Belongs to the peptidase S26 family
C1701_RS19400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1701_RS19410	COG4974	Belongs to the 'phage' integrase family
C1701_RS19415	COG1191	sigma factor activity
C1701_RS19425	COG0052	Belongs to the universal ribosomal protein uS2 family
C1701_RS19430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1701_RS19435	COG0528	UMP kinase activity
C1701_RS19440	COG0233	cytoplasmic translational termination
C1701_RS19445	COG0575	Belongs to the CDS family
C1701_RS19455	COG2856	Zn peptidase
C1701_RS19465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1701_RS19480	COG3842	ATPase activity
C1701_RS19490	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1701_RS19495	COG1177	transmembrane transport
C1701_RS19505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1701_RS19515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1701_RS19565	COG1881	PFAM PEBP family protein
C1701_RS19575	COG0501	Belongs to the peptidase M48B family
C1701_RS19585	COG1280	lysine exporter protein (LysE YggA)
C1701_RS19600	COG0156	8-amino-7-oxononanoate synthase activity
C1701_RS19605	COG2124	cytochrome p450
C1701_RS19620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1701_RS19620	COG1648	precorrin-2 dehydrogenase activity
C1701_RS19635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS19640	COG1120	ATPase activity
C1701_RS19645	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS19650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1701_RS19655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1701_RS19660	COG0513	Belongs to the DEAD box helicase family
C1701_RS19670	COG3022	response to hydroperoxide
C1701_RS19675	COG0442	prolyl-tRNA aminoacylation
C1701_RS19685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS19695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1701_RS19715	COG0779	Required for maturation of 30S ribosomal subunits
C1701_RS19730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1701_RS19755	COG4585	Histidine kinase
C1701_RS19775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1701_RS19795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1701_RS19815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1701_RS19820	COG1185	polyribonucleotide nucleotidyltransferase activity
C1701_RS19830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1701_RS19860	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C1701_RS19870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1701_RS19880	COG0277	FAD linked oxidase domain protein
C1701_RS19880	COG0247	lactate metabolic process
C1701_RS19895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1701_RS19900	COG0492	ferredoxin-NADP+ reductase activity
C1701_RS19925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1701_RS19935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1701_RS19940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1701_RS19950	COG1546	Belongs to the CinA family
C1701_RS19950	COG1058	Belongs to the CinA family
C1701_RS19955	COG1396	sequence-specific DNA binding
C1701_RS19965	COG1842	Phage shock protein A
C1701_RS19985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS19995	COG2233	PERMEase
C1701_RS20000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1701_RS20020	COG1305	Transglutaminase-like
C1701_RS20030	COG0714	Associated with various cellular activities
C1701_RS20035	COG2001	Belongs to the MraZ family
C1701_RS20040	COG0275	rRNA processing
C1701_RS20050	COG0768	penicillin binding
C1701_RS20055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1701_RS20065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1701_RS20070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1701_RS20080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1701_RS20085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1701_RS20090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1701_RS20095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS20105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1701_RS20120	COG1799	cell septum assembly
C1701_RS20130	COG3599	regulation of cell shape
C1701_RS20135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1701_RS20140	COG1872	DUF167
C1701_RS20145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1701_RS20150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1701_RS20175	COG0587	DNA-directed DNA polymerase activity
C1701_RS20180	COG2124	cytochrome p450
C1701_RS20185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1701_RS20190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1701_RS20195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1701_RS20220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1701_RS20235	COG1131	(ABC) transporter
C1701_RS20260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1701_RS20270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1701_RS20275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1701_RS20280	COG0131	Imidazoleglycerol-phosphate dehydratase
C1701_RS20290	COG3959	Transketolase, thiamine diphosphate binding domain
C1701_RS20295	COG3958	Transketolase
C1701_RS20310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1701_RS20320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1701_RS20335	COG0107	imidazoleglycerol-phosphate synthase activity
C1701_RS20350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1701_RS20360	COG0134	indole-3-glycerol-phosphate synthase activity
C1701_RS20365	COG0133	tryptophan synthase activity
C1701_RS20370	COG0159	tryptophan synthase activity
C1701_RS20375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1701_RS20380	COG0745	RESPONSE REGULATOR receiver
C1701_RS20385	COG3850	Histidine kinase
C1701_RS20385	COG0642	Histidine kinase
C1701_RS20395	COG1301	dicarboxylic acid transport
C1701_RS20400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1701_RS20410	COG1160	GTP binding
C1701_RS20455	COG3845	ABC transporter
C1701_RS20475	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1701_RS20510	COG0584	glycerophosphoryl diester phosphodiesterase
C1701_RS20520	COG2855	membrane
C1701_RS20530	COG0322	excinuclease ABC activity
C1701_RS20535	COG1660	Displays ATPase and GTPase activities
C1701_RS20545	COG1481	regulation of sporulation
C1701_RS20555	COG0126	phosphoglycerate kinase activity
C1701_RS20560	COG0149	triose-phosphate isomerase activity
C1701_RS20580	COG0025	NhaP-type Na H and K H
C1701_RS20585	COG0363	glucosamine-6-phosphate deaminase activity
C1701_RS20600	COG0166	Belongs to the GPI family
C1701_RS20605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1701_RS20615	COG0109	protoheme IX farnesyltransferase activity
C1701_RS20640	COG1169	isochorismate synthase
C1701_RS20650	COG2018	Roadblock/LC7 domain
C1701_RS20655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1701_RS20660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1701_RS20665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1701_RS20680	COG0254	rRNA binding
C1701_RS20710	COG0702	epimerase
C1701_RS20715	COG3467	pyridoxamine 5'-phosphate
C1701_RS20735	COG1175	transmembrane transport
C1701_RS20740	COG0395	ABC-type sugar transport system, permease component
C1701_RS20745	COG3507	Belongs to the glycosyl hydrolase 43 family
C1701_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS20770	COG0709	Synthesizes selenophosphate from selenide and ATP
C1701_RS20795	COG0542	response to heat
C1701_RS20800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1701_RS20850	COG0673	inositol 2-dehydrogenase activity
C1701_RS20855	COG2217	Heavy metal translocating P-type atpase
C1701_RS20880	COG3173	Aminoglycoside phosphotransferase
C1701_RS20890	COG0402	S-adenosylhomocysteine deaminase activity
C1701_RS20895	COG2124	cytochrome p450
C1701_RS20900	COG2124	cytochrome p450
C1701_RS20920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1701_RS20950	COG3401	FG-GAP repeat protein
C1701_RS20960	COG1501	Belongs to the glycosyl hydrolase 31 family
C1701_RS20970	COG1609	Transcriptional regulator
C1701_RS20980	COG0745	RESPONSE REGULATOR receiver
C1701_RS20995	COG0372	Belongs to the citrate synthase family
C1701_RS21055	COG1201	RNA secondary structure unwinding
C1701_RS21175	COG0514	ATP-dependent DNA helicase (RecQ)
C1701_RS21215	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS21220	COG2079	MmgE PrpD family protein
C1701_RS21245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1701_RS21260	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1701_RS21270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1701_RS21300	COG2217	Heavy metal translocating P-type atpase
C1701_RS21360	COG1215	transferase activity, transferring glycosyl groups
C1701_RS21365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1701_RS21370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1701_RS21385	COG1278	Cold shock
C1701_RS21400	COG1879	ABC-type sugar transport system periplasmic component
C1701_RS21405	COG1129	ABC transporter
C1701_RS21410	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1701_RS21415	COG1063	alcohol dehydrogenase
C1701_RS21430	COG2186	Transcriptional regulator
C1701_RS21435	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS21440	COG0800	Aldolase
C1701_RS21445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1701_RS21470	COG1609	Transcriptional regulator
C1701_RS21480	COG1366	Belongs to the anti-sigma-factor antagonist family
C1701_RS21490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1701_RS21500	COG0297	glycogen (starch) synthase activity
C1701_RS21505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1701_RS21510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1701_RS21510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1701_RS21515	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS21525	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS21535	COG0655	NAD(P)H dehydrogenase (quinone) activity
C1701_RS21550	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS21555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1701_RS21555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1701_RS21565	COG4638	Rieske (2fe-2S)
C1701_RS21585	COG1573	uracil-dna glycosylase
C1701_RS21590	COG1063	alcohol dehydrogenase
C1701_RS21615	COG1595	DNA-templated transcription, initiation
C1701_RS21620	COG0747	negative chemotaxis
C1701_RS21625	COG0601	transmembrane transport
C1701_RS21630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS21640	COG2936	dipeptidyl-peptidase activity
C1701_RS21645	COG3226	Transcriptional regulator
C1701_RS21690	COG0477	Major facilitator Superfamily
C1701_RS21710	COG0673	inositol 2-dehydrogenase activity
C1701_RS21730	COG0076	glutamate decarboxylase activity
C1701_RS21735	COG0288	reversible hydration of carbon dioxide
C1701_RS21745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1701_RS21760	COG2208	phosphoserine phosphatase activity
C1701_RS21760	COG2770	Histidine kinase
C1701_RS21765	COG1366	Belongs to the anti-sigma-factor antagonist family
C1701_RS21775	COG0739	heme binding
C1701_RS21785	COG2814	Major facilitator Superfamily
C1701_RS21800	COG0519	Catalyzes the synthesis of GMP from XMP
C1701_RS21800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1701_RS21820	COG0693	protein deglycase activity
C1701_RS21835	COG0477	Major facilitator Superfamily
C1701_RS21855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1701_RS21865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1701_RS21880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1701_RS21885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1701_RS21885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1701_RS21890	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1701_RS21900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1701_RS21905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1701_RS21910	COG1607	acyl-coa hydrolase
C1701_RS21915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1701_RS21945	COG2124	cytochrome p450
C1701_RS21965	COG0509	glycine decarboxylation via glycine cleavage system
C1701_RS21970	COG1716	ATPase activity
C1701_RS21990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1701_RS21990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1701_RS21995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1701_RS22015	COG3104	oligopeptide transport
C1701_RS22025	COG3572	ergothioneine biosynthetic process
C1701_RS22030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1701_RS22040	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C1701_RS22060	COG2027	D-alanyl-D-alanine carboxypeptidase
C1701_RS22065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1701_RS22080	COG3883	PFAM NLP P60 protein
C1701_RS22080	COG0791	NLP P60 protein
C1701_RS22090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1701_RS22100	COG0746	molybdenum cofactor guanylyltransferase activity
C1701_RS22105	COG0714	Associated with various cellular activities
C1701_RS22125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1701_RS22130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1701_RS22165	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS22175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1701_RS22195	COG1802	Transcriptional regulator
C1701_RS22205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1701_RS22220	COG0515	serine threonine protein kinase
C1701_RS22240	COG0515	serine threonine protein kinase
C1701_RS22250	COG0604	alcohol dehydrogenase
C1701_RS22275	COG1510	regulation of RNA biosynthetic process
C1701_RS22320	COG0396	ATPase activity
C1701_RS22330	COG0822	iron-sulfur transferase activity
C1701_RS22335	COG2151	metal-sulfur cluster biosynthetic enzyme
C1701_RS22340	COG1132	(ABC) transporter
C1701_RS22345	COG0644	oxidoreductase
C1701_RS22355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1701_RS22365	COG0488	(ABC) transporter
C1701_RS22395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1701_RS22395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1701_RS22415	COG1278	Cold shock
C1701_RS22435	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1701_RS22440	COG0823	Involved in the tonB-independent uptake of proteins
C1701_RS22440	COG1506	peptidase
C1701_RS22440	COG4946	Tricorn protease homolog
C1701_RS22460	COG2409	Drug exporters of the RND superfamily
C1701_RS22465	COG0215	cysteine-tRNA ligase activity
C1701_RS22480	COG0646	methionine synthase
C1701_RS22480	COG1410	methionine synthase
C1701_RS22485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1701_RS22505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1701_RS22515	COG1994	Peptidase M50
C1701_RS22515	COG0517	IMP dehydrogenase activity
C1701_RS22540	COG1222	aaa ATPase
C1701_RS22570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1701_RS22575	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1701_RS22595	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1701_RS22605	COG2378	regulation of single-species biofilm formation
C1701_RS22615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1701_RS22630	COG4552	Acetyltransferase involved in intracellular survival and related
C1701_RS22635	COG1950	PFAM Membrane protein of
C1701_RS22660	COG1136	(ABC) transporter
C1701_RS22665	COG1136	(ABC) transporter
C1701_RS22685	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1701_RS22700	COG0463	Glycosyl transferase, family 2
C1701_RS22710	COG1435	thymidine kinase activity
C1701_RS22740	COG4585	Histidine kinase
C1701_RS22745	COG2197	response regulator
C1701_RS22750	COG0281	malic enzyme
C1701_RS22755	COG0519	Catalyzes the synthesis of GMP from XMP
C1701_RS22790	COG2130	NADP-dependent
C1701_RS22795	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS22805	COG2855	membrane
C1701_RS22810	COG0175	sulfate reduction
C1701_RS22835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1701_RS22840	COG0028	Belongs to the TPP enzyme family
C1701_RS22860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1701_RS22865	COG0326	Molecular chaperone. Has ATPase activity
C1701_RS22875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1701_RS22880	COG0129	dihydroxy-acid dehydratase activity
C1701_RS22885	COG1063	alcohol dehydrogenase
C1701_RS22890	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C1701_RS22905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS22915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS22945	COG2986	histidine ammonia-lyase
C1701_RS22985	COG4221	oxidoreductase activity
C1701_RS23020	COG1609	Transcriptional regulator
C1701_RS23055	COG1518	maintenance of DNA repeat elements
C1701_RS23060	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C1701_RS23100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1701_RS23120	COG0671	phosphoesterase, PA-phosphatase related
C1701_RS23150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1701_RS23175	COG1454	alcohol dehydrogenase
C1701_RS23180	COG0126	phosphoglycerate kinase activity
C1701_RS23185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1701_RS23190	COG1063	alcohol dehydrogenase
C1701_RS23195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1701_RS23235	COG1473	amidohydrolase
C1701_RS23240	COG0667	Aldo Keto reductase
C1701_RS23245	COG1396	sequence-specific DNA binding
C1701_RS23285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1701_RS23290	COG1120	ATPase activity
C1701_RS23295	COG0750	zinc metalloprotease
C1701_RS23300	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS23305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1701_RS23310	COG2271	Major facilitator Superfamily
C1701_RS23315	COG1802	Transcriptional regulator
C1701_RS23325	COG2072	flavoprotein involved in K transport
C1701_RS23365	COG0657	acetylesterase activity
C1701_RS23370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1701_RS23405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS23440	COG3629	intracellular signal transduction
C1701_RS23440	COG3903	Transcriptional regulator
C1701_RS23460	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS23470	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS23480	COG2197	response regulator
C1701_RS23495	COG0477	Major facilitator Superfamily
C1701_RS23500	COG0789	Transcriptional regulator
C1701_RS23515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1701_RS23520	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS23530	COG0477	Major facilitator Superfamily
C1701_RS23560	COG2197	response regulator
C1701_RS23575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1701_RS23580	COG0187	DNA topoisomerase II activity
C1701_RS23620	COG1966	Carbon starvation protein
C1701_RS23630	COG0003	Pfam Anion-transporting ATPase
C1701_RS23645	COG0702	epimerase
C1701_RS23675	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1701_RS23795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1701_RS23805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1701_RS23810	COG0583	DNA-binding transcription factor activity
C1701_RS23815	COG0747	negative chemotaxis
C1701_RS23820	COG0601	transmembrane transport
C1701_RS23825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS23830	COG0444	Belongs to the ABC transporter superfamily
C1701_RS23835	COG4608	Belongs to the ABC transporter superfamily
C1701_RS23850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1701_RS23855	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS23860	COG1414	Transcriptional regulator
C1701_RS23865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1701_RS23880	COG2080	2 iron, 2 sulfur cluster binding
C1701_RS23880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1701_RS23920	COG1132	(ABC) transporter
C1701_RS23925	COG1132	(ABC) transporter
C1701_RS23935	COG0019	diaminopimelate decarboxylase activity
C1701_RS23955	COG2192	nodulation
C1701_RS23995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS24110	COG1472	Belongs to the glycosyl hydrolase 3 family
C1701_RS24115	COG1609	Transcriptional regulator
C1701_RS24130	COG0395	ABC-type sugar transport system, permease component
C1701_RS24170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1701_RS24170	COG2070	2-Nitropropane dioxygenase
C1701_RS24200	COG0673	inositol 2-dehydrogenase activity
C1701_RS24210	COG3973	AAA domain
C1701_RS24230	COG1802	Transcriptional regulator
C1701_RS24240	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS24245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1701_RS24255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1701_RS24260	COG2376	Dihydroxyacetone kinase
C1701_RS24265	COG0698	ribose 5-phosphate isomerase
C1701_RS24280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C1701_RS24285	COG2706	6-phosphogluconolactonase activity
C1701_RS24295	COG1175	transmembrane transport
C1701_RS24300	COG0395	ABC-type sugar transport system, permease component
C1701_RS24305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1701_RS24370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1701_RS24375	COG0402	S-adenosylhomocysteine deaminase activity
C1701_RS24415	COG3401	FG-GAP repeat protein
C1701_RS24420	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
C1701_RS24490	COG1132	(ABC) transporter
C1701_RS24495	COG0477	Major facilitator Superfamily
C1701_RS24505	COG2890	protein-(glutamine-N5) methyltransferase activity
C1701_RS24510	COG1357	PFAM Pentapeptide repeats (8 copies)
C1701_RS24525	COG1028	Short-chain dehydrogenase reductase Sdr
C1701_RS24555	COG0242	peptide deformylase activity
C1701_RS24565	COG0697	spore germination
C1701_RS24585	COG3795	YCII-related domain
C1701_RS24600	COG2318	DinB family
C1701_RS24620	COG0488	(ABC) transporter
C1701_RS24640	COG0583	DNA-binding transcription factor activity
C1701_RS24650	COG4977	sequence-specific DNA binding
C1701_RS24655	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1701_RS24660	COG0110	maltose O-acetyltransferase activity
C1701_RS24670	COG4974	Belongs to the 'phage' integrase family
C1701_RS24680	COG1739	Uncharacterized protein family UPF0029
C1701_RS24685	COG2362	D-Aminopeptidase
C1701_RS24690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1701_RS24700	COG0601	transmembrane transport
C1701_RS24705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS24725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1701_RS24750	COG2272	Belongs to the type-B carboxylesterase lipase family
C1701_RS24795	COG1796	DNA polymerase
C1701_RS24795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1701_RS24800	COG0402	S-adenosylhomocysteine deaminase activity
C1701_RS24840	COG3845	ABC transporter
C1701_RS24845	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1701_RS24850	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1701_RS24870	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C1701_RS24875	COG0235	Class ii aldolase
C1701_RS24880	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C1701_RS24890	COG5297	Belongs to the glycosyl hydrolase family 6
C1701_RS24910	COG0702	epimerase
C1701_RS24920	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C1701_RS24925	COG1304	FMN binding
C1701_RS24940	COG0792	nuclease activity
C1701_RS24965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1701_RS24995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1701_RS25010	COG1968	undecaprenyl-diphosphatase activity
C1701_RS25015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1701_RS25020	COG0667	Aldo Keto reductase
C1701_RS25040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1701_RS25070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS25090	COG2423	ornithine cyclodeaminase activity
C1701_RS25095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1701_RS25140	COG1192	Involved in chromosome partitioning
C1701_RS25155	COG4221	oxidoreductase activity
C1701_RS25195	COG2353	YceI-like domain
C1701_RS25205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1701_RS25225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1701_RS25275	COG0473	3-isopropylmalate dehydrogenase activity
C1701_RS25285	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C1701_RS25300	COG0563	adenylate kinase activity
C1701_RS25310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1701_RS25315	COG2226	methyltransferase
C1701_RS25330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1701_RS25340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1701_RS25365	COG0640	Transcriptional regulator
C1701_RS25370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1701_RS25375	COG2197	response regulator
C1701_RS25380	COG4585	Histidine kinase
C1701_RS25400	COG1215	transferase activity, transferring glycosyl groups
C1701_RS25410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1701_RS25420	COG0747	negative chemotaxis
C1701_RS25430	COG2186	Transcriptional regulator
C1701_RS25440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1701_RS25445	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS25450	COG1819	glycosyl
C1701_RS25500	COG4948	Mandelate Racemase Muconate Lactonizing
C1701_RS25535	COG0583	DNA-binding transcription factor activity
C1701_RS25580	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
C1701_RS25620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS25635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS25695	COG1131	(ABC) transporter
C1701_RS25700	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1701_RS25705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1701_RS25725	COG2175	clavaminate synthase activity
C1701_RS25740	COG1131	(ABC) transporter
C1701_RS25765	COG3321	synthase
C1701_RS25765	COG0604	alcohol dehydrogenase
C1701_RS25770	COG3321	synthase
C1701_RS25770	COG0604	alcohol dehydrogenase
C1701_RS25845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1701_RS25885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1701_RS25900	COG2353	YceI-like domain
C1701_RS25915	COG3321	synthase
C1701_RS25915	COG0604	alcohol dehydrogenase
C1701_RS25920	COG3321	synthase
C1701_RS25920	COG0604	alcohol dehydrogenase
C1701_RS25930	COG0604	alcohol dehydrogenase
C1701_RS25930	COG3321	synthase
C1701_RS25930	COG0604	alcohol dehydrogenase
C1701_RS25930	COG3321	synthase
C1701_RS26005	COG0604	alcohol dehydrogenase
C1701_RS26005	COG0604	alcohol dehydrogenase
C1701_RS26005	COG3321	synthase
C1701_RS26005	COG3321	synthase
C1701_RS26010	COG0667	Aldo Keto reductase
C1701_RS26035	COG1131	(ABC) transporter
C1701_RS26090	COG0604	alcohol dehydrogenase
C1701_RS26090	COG3321	synthase
C1701_RS26105	COG3321	synthase
C1701_RS26105	COG0604	alcohol dehydrogenase
C1701_RS26125	COG3321	synthase
C1701_RS26125	COG0604	alcohol dehydrogenase
C1701_RS26135	COG3321	synthase
C1701_RS26135	COG0604	alcohol dehydrogenase
C1701_RS26150	COG3321	synthase
C1701_RS26150	COG0604	alcohol dehydrogenase
C1701_RS26155	COG0604	alcohol dehydrogenase
C1701_RS26155	COG3321	synthase
C1701_RS26170	COG0604	alcohol dehydrogenase
C1701_RS26170	COG3321	synthase
C1701_RS26205	COG0259	pyridoxamine-phosphate oxidase activity
C1701_RS26225	COG1733	regulation of RNA biosynthetic process
C1701_RS26250	COG1857	crispr-associated protein
C1701_RS26325	COG2207	Transcriptional regulator
C1701_RS26325	COG1609	Transcriptional regulator
C1701_RS26330	COG2124	cytochrome p450
C1701_RS26385	COG1917	Cupin 2, conserved barrel domain protein
C1701_RS26385	COG4977	sequence-specific DNA binding
C1701_RS26410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1701_RS26420	COG2124	cytochrome p450
C1701_RS26460	COG0596	Alpha beta hydrolase
C1701_RS26465	COG0477	Major facilitator Superfamily
C1701_RS26480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1701_RS26495	COG2124	cytochrome p450
C1701_RS26505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS26520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS26525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS26605	COG3251	PFAM MbtH domain protein
C1701_RS26610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS26620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1701_RS26625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1701_RS26640	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1701_RS26645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1701_RS26670	COG0475	glutathione-regulated potassium exporter activity
C1701_RS26695	COG0464	growth
C1701_RS26700	COG2197	response regulator
C1701_RS26765	COG1674	ftsk spoiiie
C1701_RS26815	COG2271	Major facilitator Superfamily
C1701_RS26825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1701_RS26840	COG1414	Transcriptional regulator
C1701_RS26855	COG0506	proline dehydrogenase activity
C1701_RS26860	COG1012	belongs to the aldehyde dehydrogenase family
C1701_RS26870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1701_RS26875	COG0656	L-ascorbic acid biosynthetic process
C1701_RS26895	COG1785	Belongs to the alkaline phosphatase family
C1701_RS26915	COG4221	oxidoreductase activity