locus-tag	class	description
EXH44_RS00045	COG0328	RNA-DNA hybrid ribonuclease activity
EXH44_RS00095	COG2731	YhcH YjgK YiaL family protein
EXH44_RS00100	COG1737	Transcriptional regulator
EXH44_RS00110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXH44_RS00120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXH44_RS00125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EXH44_RS00130	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXH44_RS00135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXH44_RS00145	COG1448	Aminotransferase
EXH44_RS00155	COG0285	dihydrofolate synthase activity
EXH44_RS00165	COG0732	type I restriction modification DNA specificity domain
EXH44_RS00175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXH44_RS00180	COG1846	Transcriptional regulator
EXH44_RS00180	COG1940	carbohydrate kinase activity
EXH44_RS00185	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EXH44_RS00200	COG0857	belongs to the CobB CobQ family
EXH44_RS00200	COG0280	phosphate acetyltransferase
EXH44_RS00205	COG0023	Translation Initiation Factor
EXH44_RS00215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EXH44_RS00220	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EXH44_RS00230	COG0539	negative regulation of cytoplasmic translation
EXH44_RS00235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXH44_RS00240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXH44_RS00245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXH44_RS00255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXH44_RS00260	COG0589	response to stress
EXH44_RS00270	COG2363	Small membrane protein
EXH44_RS00285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXH44_RS00290	COG0314	molybdopterin synthase activity
EXH44_RS00305	COG1444	tRNA N-acetyltransferase activity
EXH44_RS00310	COG1879	ABC-type sugar transport system periplasmic component
EXH44_RS00315	COG1129	ABC transporter
EXH44_RS00320	COG4211	Belongs to the binding-protein-dependent transport system permease family
EXH44_RS00330	COG1494	fructose-1,6-bisphosphatase
EXH44_RS00345	COG2837	iron assimilation
EXH44_RS00350	COG2822	iron ion transport
EXH44_RS00365	COG2864	formate dehydrogenase
EXH44_RS00370	COG0437	4 iron, 4 sulfur cluster binding
EXH44_RS00385	COG0372	Belongs to the citrate synthase family
EXH44_RS00395	COG0538	isocitrate dehydrogenase activity
EXH44_RS00400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXH44_RS00410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXH44_RS00420	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EXH44_RS00425	COG0527	aspartate kinase activity
EXH44_RS00430	COG2814	Major facilitator Superfamily
EXH44_RS00435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXH44_RS00445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EXH44_RS00445	COG3264	Mechanosensitive ion channel
EXH44_RS00450	COG0318	PFAM AMP-dependent synthetase and ligase
EXH44_RS00460	COG0596	Alpha beta hydrolase
EXH44_RS00465	COG2969	positive regulation of protein catabolic process
EXH44_RS00470	COG0625	glutathione transferase activity
EXH44_RS00490	COG0006	proline dipeptidase activity
EXH44_RS00495	COG3956	TIGRFAM MazG family protein
EXH44_RS00500	COG0745	RESPONSE REGULATOR receiver
EXH44_RS00505	COG2205	protein histidine kinase activity
EXH44_RS00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXH44_RS00515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXH44_RS00520	COG1136	(ABC) transporter
EXH44_RS00520	COG0577	efflux transmembrane transporter activity
EXH44_RS00525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXH44_RS00530	COG1840	ABC-type Fe3 transport system, periplasmic component
EXH44_RS00535	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EXH44_RS00540	COG3422	double-strand break repair
EXH44_RS00555	COG0556	nucleotide-excision repair
EXH44_RS00560	COG1509	lysine 2,3-aminomutase activity
EXH44_RS00575	COG3074	FtsZ-dependent cytokinesis
EXH44_RS00590	COG1368	sulfuric ester hydrolase activity
EXH44_RS00595	COG0633	Ferredoxin
EXH44_RS00595	COG3217	Mosc domain protein beta barrel domain protein
EXH44_RS00600	COG1722	exodeoxyribonuclease VII activity
EXH44_RS00605	COG0142	geranyltranstransferase activity
EXH44_RS00610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXH44_RS00620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EXH44_RS00640	COG3047	cAMP biosynthetic process
EXH44_RS00645	COG0564	pseudouridine synthase activity
EXH44_RS00650	COG0588	phosphoglycerate mutase activity
EXH44_RS00665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXH44_RS00670	COG2027	D-alanyl-D-alanine carboxypeptidase
EXH44_RS00680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXH44_RS00690	COG0561	phosphatase activity
EXH44_RS00700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXH44_RS00705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXH44_RS00710	COG0739	heme binding
EXH44_RS00715	COG1121	(ABC) transporter
EXH44_RS00720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXH44_RS00725	COG0121	glutamine amidotransferase
EXH44_RS00730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EXH44_RS00740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXH44_RS00745	COG1349	DNA-binding transcription factor activity
EXH44_RS00825	COG0640	Transcriptional regulator
EXH44_RS00840	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS00845	COG0511	ligase activity, forming carbon-carbon bonds
EXH44_RS00925	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS00950	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS00975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXH44_RS00985	COG1946	Acyl-CoA thioesterase
EXH44_RS01005	COG0590	tRNA wobble adenosine to inosine editing
EXH44_RS01010	COG0513	Belongs to the DEAD box helicase family
EXH44_RS01015	COG4785	May be involved in cell division
EXH44_RS01025	COG4166	transmembrane transport
EXH44_RS01030	COG3684	Belongs to the aldolase LacD family
EXH44_RS01050	COG3716	PTS system mannose fructose sorbose family IID component
EXH44_RS01060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXH44_RS01065	COG2222	sugar isomerase
EXH44_RS01070	COG1349	DNA-binding transcription factor activity
EXH44_RS01075	COG0312	modulator of DNA gyrase
EXH44_RS01085	COG3094	Invasion gene expression up-regulator, SirB
EXH44_RS01110	COG3036	rescue of stalled ribosome
EXH44_RS01115	COG2226	methyltransferase
EXH44_RS01135	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXH44_RS01140	COG3657	addiction module killer protein
EXH44_RS01145	COG2333	competence protein COMEC
EXH44_RS01145	COG0658	competence protein
EXH44_RS01155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXH44_RS01165	COG0737	Belongs to the 5'-nucleotidase family
EXH44_RS01180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXH44_RS01195	COG1556	Lactate utilization protein
EXH44_RS01200	COG1139	Iron-sulfur cluster binding protein
EXH44_RS01205	COG0247	lactate metabolic process
EXH44_RS01210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXH44_RS01215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXH44_RS01220	COG0730	response to heat
EXH44_RS01225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXH44_RS01230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXH44_RS01235	COG0583	DNA-binding transcription factor activity
EXH44_RS01240	COG4172	Belongs to the ABC transporter superfamily
EXH44_RS01245	COG4171	peptide transport system, permease
EXH44_RS01250	COG4168	peptide transport system, permease
EXH44_RS01255	COG4166	transmembrane transport
EXH44_RS01260	COG3283	Transcriptional regulator of aromatic amino acids metabolism
EXH44_RS01265	COG1686	Belongs to the peptidase S11 family
EXH44_RS01270	COG0528	UMP kinase activity
EXH44_RS01275	COG2194	sulfuric ester hydrolase activity
EXH44_RS01280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXH44_RS01280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXH44_RS01290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXH44_RS01295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXH44_RS01300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXH44_RS01305	COG1760	l-serine dehydratase
EXH44_RS01310	COG0814	amino acid
EXH44_RS01325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXH44_RS01330	COG0737	Belongs to the 5'-nucleotidase family
EXH44_RS01335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXH44_RS01345	COG5645	(Lipo)protein
EXH44_RS01355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXH44_RS01360	COG4988	ABC transporter
EXH44_RS01365	COG2911	Protein conserved in bacteria
EXH44_RS01370	COG0729	surface antigen
EXH44_RS01375	COG2861	carbohydrate metabolic process
EXH44_RS01380	COG4942	peptidase
EXH44_RS01385	COG0318	PFAM AMP-dependent synthetase and ligase
EXH44_RS01390	COG3086	response to oxidative stress
EXH44_RS01395	COG3026	antisigma factor binding
EXH44_RS01410	COG2350	Protein conserved in bacteria
EXH44_RS01415	COG1607	acyl-coa hydrolase
EXH44_RS01430	COG3092	negative regulation of chromosome organization
EXH44_RS01455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXH44_RS01480	COG0305	Participates in initiation and elongation during chromosome replication
EXH44_RS01485	COG0613	PHP domain protein
EXH44_RS01495	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
EXH44_RS01500	COG2925	Exonuclease
EXH44_RS01505	COG0842	Transport permease protein
EXH44_RS01510	COG1131	(ABC) transporter
EXH44_RS01515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXH44_RS01520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXH44_RS01525	COG2814	Major facilitator Superfamily
EXH44_RS01530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXH44_RS01540	COG0617	tRNA 3'-terminal CCA addition
EXH44_RS01545	COG2975	iron-sulfur cluster assembly
EXH44_RS01550	COG0633	Ferredoxin
EXH44_RS01580	COG0822	iron-sulfur transferase activity
EXH44_RS01590	COG1959	2 iron, 2 sulfur cluster binding
EXH44_RS01595	COG3691	Protein conserved in bacteria
EXH44_RS01605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXH44_RS01610	COG0626	cystathionine gamma-synthase activity
EXH44_RS01615	COG2252	PERMEase
EXH44_RS01625	COG0133	tryptophan synthase activity
EXH44_RS01630	COG4221	oxidoreductase activity
EXH44_RS01635	COG2983	Belongs to the UPF0260 family
EXH44_RS01640	COG0393	Putative heavy-metal-binding
EXH44_RS01645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EXH44_RS01650	COG1560	Kdo2-lipid A biosynthetic process
EXH44_RS01660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EXH44_RS01670	COG0302	gtp cyclohydrolase
EXH44_RS01675	COG3642	lipopolysaccharide core region biosynthetic process
EXH44_RS01680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXH44_RS01695	COG3676	manually curated
EXH44_RS01725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXH44_RS01730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EXH44_RS01735	COG1792	Involved in formation and maintenance of cell shape
EXH44_RS01740	COG1077	Cell shape determining protein MreB Mrl
EXH44_RS01745	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EXH44_RS01750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EXH44_RS01760	COG0475	glutathione-regulated potassium exporter activity
EXH44_RS01760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXH44_RS01775	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS01780	COG2062	phosphohistidine phosphatase, SixA
EXH44_RS01785	COG0469	pyruvate kinase activity
EXH44_RS01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXH44_RS01795	COG0659	secondary active sulfate transmembrane transporter activity
EXH44_RS01800	COG3038	cytochrome b561
EXH44_RS01810	COG1473	amidohydrolase
EXH44_RS01815	COG2079	MmgE PrpD family protein
EXH44_RS01820	COG1126	abc transporter atp-binding protein
EXH44_RS01825	COG0765	amino acid transport
EXH44_RS01830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXH44_RS01835	COG0456	acetyltransferase
EXH44_RS01850	COG0583	DNA-binding transcription factor activity
EXH44_RS01855	COG1011	Hydrolase
EXH44_RS01860	COG0583	DNA-binding transcription factor activity
EXH44_RS01865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXH44_RS01870	COG0251	oxidation-reduction process
EXH44_RS01885	COG3676	manually curated
EXH44_RS01905	COG0494	nUDIX hydrolase
EXH44_RS01935	COG1643	Atp-dependent helicase
EXH44_RS01940	COG5002	protein histidine kinase activity
EXH44_RS01940	COG0784	Response regulator, receiver
EXH44_RS01940	COG2198	Histidine kinase
EXH44_RS01945	COG0697	spore germination
EXH44_RS01950	COG2840	Smr protein MutS2
EXH44_RS01960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EXH44_RS01965	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXH44_RS01970	COG4969	Belongs to the N-Me-Phe pilin family
EXH44_RS01975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXH44_RS01980	COG1459	type II secretion system
EXH44_RS01990	COG0237	dephospho-CoA kinase activity
EXH44_RS01995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EXH44_RS02005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXH44_RS02010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EXH44_RS02025	COG0750	zinc metalloprotease
EXH44_RS02030	COG0575	Belongs to the CDS family
EXH44_RS02035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EXH44_RS02045	COG1940	carbohydrate kinase activity
EXH44_RS02050	COG0671	phosphoesterase, PA-phosphatase related
EXH44_RS02055	COG1534	Rna-binding protein
EXH44_RS02060	COG0463	Glycosyl transferase, family 2
EXH44_RS02065	COG0859	PFAM glycosyl transferase family 9
EXH44_RS02080	COG3306	glycosyltransferase involved in LPS biosynthesis
EXH44_RS02090	COG0859	PFAM glycosyl transferase family 9
EXH44_RS02095	COG0583	DNA-binding transcription factor activity
EXH44_RS02115	COG1704	LemA family
EXH44_RS02125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXH44_RS02135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EXH44_RS02145	COG0823	Involved in the tonB-independent uptake of proteins
EXH44_RS02150	COG3064	Membrane
EXH44_RS02150	COG3064	Membrane
EXH44_RS02155	COG0848	biopolymer transport protein
EXH44_RS02160	COG0811	peptide transport
EXH44_RS02165	COG0824	Thioesterase
EXH44_RS02180	COG1294	oxidase, subunit
EXH44_RS02185	COG1271	oxidase subunit
EXH44_RS02195	COG3071	HemY protein
EXH44_RS02200	COG2959	enzyme of heme biosynthesis
EXH44_RS02205	COG1587	Uroporphyrinogen-III synthase
EXH44_RS02210	COG0181	hydroxymethylbilane synthase activity
EXH44_RS02215	COG1115	amino acid carrier protein
EXH44_RS02220	COG4608	Belongs to the ABC transporter superfamily
EXH44_RS02225	COG0444	Belongs to the ABC transporter superfamily
EXH44_RS02230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXH44_RS02235	COG0601	transmembrane transport
EXH44_RS02240	COG4166	transmembrane transport
EXH44_RS02250	COG2255	four-way junction helicase activity
EXH44_RS02255	COG0632	four-way junction helicase activity
EXH44_RS02260	COG1177	transmembrane transport
EXH44_RS02265	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXH44_RS02270	COG3842	ATPase activity
EXH44_RS02275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXH44_RS02280	COG0346	lactoylglutathione lyase activity
EXH44_RS02285	COG4139	cobalamin transport
EXH44_RS02305	COG2911	Protein conserved in bacteria
EXH44_RS02315	COG1943	Transposase
EXH44_RS02340	COG2183	response to ionizing radiation
EXH44_RS02345	COG0697	spore germination
EXH44_RS02350	COG2081	HI0933 family
EXH44_RS02355	COG0497	DNA recombination
EXH44_RS02360	COG0494	nUDIX hydrolase
EXH44_RS02390	COG0271	Belongs to the BolA IbaG family
EXH44_RS02395	COG3056	Lipoprotein
EXH44_RS02400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXH44_RS02405	COG1678	Uncharacterized ACR, COG1678
EXH44_RS02415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EXH44_RS02420	COG1862	Preprotein translocase
EXH44_RS02425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXH44_RS02430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXH44_RS02475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXH44_RS02485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXH44_RS02490	COG0778	Nitroreductase
EXH44_RS02495	COG4172	Belongs to the ABC transporter superfamily
EXH44_RS02500	COG0191	fructose-bisphosphate aldolase activity
EXH44_RS02505	COG0126	phosphoglycerate kinase activity
EXH44_RS02510	COG0471	metal ion transport
EXH44_RS02515	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS02520	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXH44_RS02525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXH44_RS02530	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXH44_RS02535	COG4133	protoheme IX ABC transporter activity
EXH44_RS02540	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXH44_RS02545	COG3201	nicotinamide mononucleotide transporter
EXH44_RS02550	COG2976	Protein conserved in bacteria
EXH44_RS02560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXH44_RS02565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXH44_RS02570	COG1426	Protein conserved in bacteria
EXH44_RS02575	COG0616	signal peptide processing
EXH44_RS02580	COG0778	Nitroreductase
EXH44_RS02585	COG3101	peptidyl-lysine hydroxylation
EXH44_RS02595	COG2853	Lipoprotein
EXH44_RS02600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXH44_RS02605	COG3108	Peptidase M15
EXH44_RS02610	COG2989	Protein conserved in bacteria
EXH44_RS02615	COG0793	Belongs to the peptidase S41A family
EXH44_RS02620	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EXH44_RS02625	COG1278	Cold shock
EXH44_RS02630	COG0492	ferredoxin-NADP+ reductase activity
EXH44_RS02635	COG3118	belongs to the thioredoxin family
EXH44_RS02655	COG1090	epimerase
EXH44_RS02665	COG0583	DNA-binding transcription factor activity
EXH44_RS02675	COG0733	neurotransmitter:sodium symporter activity
EXH44_RS02680	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXH44_RS02685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXH44_RS02690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXH44_RS02695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXH44_RS02720	COG4796	Type ii and iii secretion system protein
EXH44_RS02730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EXH44_RS02735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXH44_RS02740	COG1280	lysine exporter protein (LysE YggA)
EXH44_RS02745	COG1609	Transcriptional regulator
EXH44_RS02750	COG2268	Band 7 protein
EXH44_RS02755	COG2841	Protein conserved in bacteria
EXH44_RS02765	COG0210	DNA helicase
EXH44_RS02780	COG4160	amino acid transport
EXH44_RS02785	COG4215	(ABC) transporter
EXH44_RS02790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXH44_RS02795	COG1126	abc transporter atp-binding protein
EXH44_RS02800	COG4608	Belongs to the ABC transporter superfamily
EXH44_RS02805	COG0444	Belongs to the ABC transporter superfamily
EXH44_RS02810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXH44_RS02815	COG0601	transmembrane transport
EXH44_RS02820	COG0747	negative chemotaxis
EXH44_RS02825	COG0563	adenylate kinase activity
EXH44_RS02830	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
EXH44_RS02845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXH44_RS02850	COG1136	(ABC) transporter
EXH44_RS02855	COG4591	ABC-type transport system involved in lipoprotein release permease component
EXH44_RS02865	COG0174	glutamine synthetase
EXH44_RS02870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EXH44_RS02890	COG0366	Alpha amylase catalytic
EXH44_RS02895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXH44_RS02895	COG1263	PTS System
EXH44_RS02905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXH44_RS02925	COG0210	DNA helicase
EXH44_RS02930	COG1074	ATP-dependent DNA helicase activity
EXH44_RS02935	COG1640	4-alpha-glucanotransferase
EXH44_RS02940	COG3833	ABC-type maltose transport systems, permease component
EXH44_RS02955	COG3842	ATPase activity
EXH44_RS02960	COG4580	involved in the transport of maltose and maltodextrins
EXH44_RS02970	COG0366	Alpha amylase catalytic
EXH44_RS02975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EXH44_RS02990	COG1132	(ABC) transporter
EXH44_RS03010	COG5633	Lipoprotein
EXH44_RS03015	COG0537	adenosine 5'-monophosphoramidase activity
EXH44_RS03050	COG3068	Protein conserved in bacteria
EXH44_RS03055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXH44_RS03060	COG0676	glucose-6-phosphate 1-epimerase activity
EXH44_RS03080	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
EXH44_RS03095	COG0308	aminopeptidase N
EXH44_RS03105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EXH44_RS03110	COG0187	DNA topoisomerase II activity
EXH44_RS03115	COG0789	Transcriptional regulator
EXH44_RS03120	COG2608	mercury ion transmembrane transporter activity
EXH44_RS03140	COG0849	cell division
EXH44_RS03165	COG0772	Belongs to the SEDS family
EXH44_RS03170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXH44_RS03180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXH44_RS03195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXH44_RS03200	COG0768	penicillin binding
EXH44_RS03205	COG3116	cell division
EXH44_RS03230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXH44_RS03250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXH44_RS03250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXH44_RS03255	COG1105	Belongs to the carbohydrate kinase PfkB family
EXH44_RS03260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXH44_RS03260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXH44_RS03260	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EXH44_RS03265	COG0517	IMP dehydrogenase activity
EXH44_RS03265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EXH44_RS03270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXH44_RS03275	COG3008	intermembrane lipid transfer
EXH44_RS03280	COG0735	belongs to the Fur family
EXH44_RS03285	COG0716	FMN binding
EXH44_RS03300	COG1040	competence protein
EXH44_RS03305	COG0084	hydrolase, TatD family'
EXH44_RS03310	COG1966	Carbon starvation protein
EXH44_RS03320	COG1294	oxidase, subunit
EXH44_RS03325	COG1271	oxidase subunit
EXH44_RS03330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXH44_RS03335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXH44_RS03340	COG1187	pseudouridine synthase activity
EXH44_RS03345	COG0009	L-threonylcarbamoyladenylate synthase
EXH44_RS03350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXH44_RS03355	COG0512	Glutamine amidotransferase of anthranilate synthase
EXH44_RS03370	COG2354	Protein conserved in bacteria
EXH44_RS03390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXH44_RS03400	COG5007	Belongs to the BolA IbaG family
EXH44_RS03410	COG2854	intermembrane phospholipid transfer
EXH44_RS03415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EXH44_RS03420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EXH44_RS03425	COG1127	ABC transporter
EXH44_RS03435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EXH44_RS03440	COG0792	nuclease activity
EXH44_RS03455	COG0783	Belongs to the Dps family
EXH44_RS03460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXH44_RS03470	COG0196	riboflavin kinase activity
EXH44_RS03500	COG1793	dna ligase
EXH44_RS03515	COG0511	ligase activity, forming carbon-carbon bonds
EXH44_RS03515	COG5016	pyruvate
EXH44_RS03520	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EXH44_RS03525	COG2824	Alkylphosphonate utilization operon protein PhnA
EXH44_RS03535	COG1858	cytochrome C peroxidase
EXH44_RS03540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXH44_RS03545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXH44_RS03565	COG3301	Polysulphide reductase, NrfD
EXH44_RS03570	COG0437	4 iron, 4 sulfur cluster binding
EXH44_RS03575	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EXH44_RS03615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXH44_RS03630	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXH44_RS03640	COG0592	DNA-directed DNA polymerase activity
EXH44_RS03645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXH44_RS03650	COG1666	GTP binding
EXH44_RS03655	COG0560	Phosphoserine phosphatase
EXH44_RS03670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXH44_RS03700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXH44_RS03710	COG1720	tRNA m6t6A37 methyltransferase activity
EXH44_RS03715	COG1575	Belongs to the MenA family. Type 1 subfamily
EXH44_RS03720	COG0316	Belongs to the HesB IscA family
EXH44_RS03765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXH44_RS03790	COG3307	-O-antigen
EXH44_RS03810	COG1584	GPR1 FUN34 yaaH family protein
EXH44_RS03815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXH44_RS03820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXH44_RS03830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EXH44_RS03830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EXH44_RS03830	COG0506	proline dehydrogenase activity
EXH44_RS03835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXH44_RS03855	COG0545	Peptidyl-prolyl cis-trans isomerase
EXH44_RS03860	COG1022	Amp-dependent synthetase and ligase
EXH44_RS03870	COG1482	cell wall glycoprotein biosynthetic process
EXH44_RS03880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXH44_RS03885	COG2190	(PTS) system
EXH44_RS03890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EXH44_RS03895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXH44_RS03900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXH44_RS03915	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EXH44_RS03925	COG1289	transmembrane transporter activity
EXH44_RS03935	COG3133	Outer membrane lipoprotein
EXH44_RS03940	COG3102	Protein conserved in bacteria
EXH44_RS03945	COG0018	arginyl-trna synthetase
EXH44_RS03950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXH44_RS03960	COG2850	peptidyl-arginine hydroxylation
EXH44_RS03965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EXH44_RS03980	COG4545	Glutaredoxin-related protein
EXH44_RS04025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EXH44_RS04030	COG3172	ATPase kinase involved in NAD metabolism
EXH44_RS04035	COG2129	metallophosphoesterase
EXH44_RS04045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXH44_RS04060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXH44_RS04065	COG0765	amino acid transport
EXH44_RS04070	COG1126	abc transporter atp-binding protein
EXH44_RS04075	COG0678	peroxiredoxin activity
EXH44_RS04075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EXH44_RS04080	COG0583	DNA-binding transcription factor activity
EXH44_RS04090	COG3676	manually curated
EXH44_RS04100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXH44_RS04115	COG2226	methyltransferase
EXH44_RS04120	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EXH44_RS04125	COG1970	mechanosensitive ion channel activity
EXH44_RS04130	COG3676	manually curated
EXH44_RS04135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXH44_RS04140	COG3719	Belongs to the RNase T2 family
EXH44_RS04155	COG1120	ATPase activity
EXH44_RS04160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXH44_RS04170	COG4774	siderophore transport
EXH44_RS04180	COG3084	Protein conserved in bacteria
EXH44_RS04185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXH44_RS04195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXH44_RS04205	COG0728	peptidoglycan biosynthetic process
EXH44_RS04215	COG0546	phosphoglycolate phosphatase activity
EXH44_RS04225	COG0730	response to heat
EXH44_RS04240	COG0745	RESPONSE REGULATOR receiver
EXH44_RS04245	COG0642	Histidine kinase
EXH44_RS04255	COG1561	YicC-like family, N-terminal region
EXH44_RS04260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EXH44_RS04265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EXH44_RS04265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EXH44_RS04275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EXH44_RS04280	COG0501	Belongs to the peptidase M48B family
EXH44_RS04285	COG0490	domain, Protein
EXH44_RS04285	COG0471	metal ion transport
EXH44_RS04315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXH44_RS04330	COG1442	glycosyl transferase family 8
EXH44_RS04330	COG1216	Glycosyl transferase, family 2
EXH44_RS04335	COG0438	transferase activity, transferring glycosyl groups
EXH44_RS04365	COG0180	Tryptophanyl-tRNA synthetase
EXH44_RS04370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXH44_RS04375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXH44_RS04380	COG3384	dioxygenase
EXH44_RS04390	COG3676	manually curated
EXH44_RS04405	COG0697	spore germination
EXH44_RS04410	COG0697	spore germination
EXH44_RS04425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXH44_RS04435	COG0742	ribosomal rna small subunit methyltransferase
EXH44_RS04440	COG0552	protein localization to endoplasmic reticulum
EXH44_RS04445	COG2884	Cell division ATP-binding protein ftsE
EXH44_RS04450	COG2177	Part of the ABC transporter FtsEX involved in
EXH44_RS04455	COG0598	Magnesium transport protein CorA
EXH44_RS04465	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EXH44_RS04470	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EXH44_RS04480	COG0778	Nitroreductase
EXH44_RS04485	COG3691	Protein conserved in bacteria
EXH44_RS04490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EXH44_RS04505	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXH44_RS04520	COG0037	tRNA processing
EXH44_RS04530	COG4974	Belongs to the 'phage' integrase family
EXH44_RS04580	COG3161	chorismate lyase activity
EXH44_RS04590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXH44_RS04595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXH44_RS04615	COG2264	protein methyltransferase activity
EXH44_RS04635	COG0439	Biotin carboxylase
EXH44_RS04650	COG0110	maltose O-acetyltransferase activity
EXH44_RS04685	COG1280	lysine exporter protein (LysE YggA)
EXH44_RS04690	COG1902	pentaerythritol trinitrate reductase activity
EXH44_RS04690	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXH44_RS04695	COG0640	Transcriptional regulator
EXH44_RS04705	COG2910	NAD(P)H-binding
EXH44_RS04710	COG1733	regulation of RNA biosynthetic process
EXH44_RS04720	COG3111	PFAM Bacterial OB fold (BOF) protein
EXH44_RS04735	COG1522	sequence-specific DNA binding
EXH44_RS04740	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EXH44_RS04745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXH44_RS04760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXH44_RS04765	COG0606	chelatase, subunit chli
EXH44_RS04770	COG0470	DNA polymerase III
EXH44_RS04790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXH44_RS04820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EXH44_RS04825	COG1238	metal cluster binding
EXH44_RS04835	COG4942	peptidase
EXH44_RS04835	COG1388	LysM domain
EXH44_RS04845	COG2818	Glycosylase
EXH44_RS04850	COG2091	lysine biosynthetic process via aminoadipic acid
EXH44_RS04860	COG0494	nUDIX hydrolase
EXH44_RS04885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXH44_RS04890	COG0335	large ribosomal subunit rRNA binding
EXH44_RS04910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXH44_RS04925	COG0202	RNA polymerase activity
EXH44_RS04940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXH44_RS04950	COG0201	protein transport
EXH44_RS04955	COG0200	Binds to the 23S rRNA
EXH44_RS04965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EXH44_RS04980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXH44_RS05010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXH44_RS05040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EXH44_RS05045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXH44_RS05050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXH44_RS05060	COG0089	rRNA binding
EXH44_RS05075	COG0051	transcription antitermination factor activity, RNA binding
EXH44_RS05080	COG3070	regulator of competence-specific genes
EXH44_RS05090	COG0758	DNA mediated transformation
EXH44_RS05105	COG1129	ABC transporter
EXH44_RS05125	COG2610	gluconate transmembrane transporter activity
EXH44_RS05130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXH44_RS05135	COG3622	Belongs to the hyi family
EXH44_RS05140	COG0235	Class ii aldolase
EXH44_RS05145	COG3395	kinase activity
EXH44_RS05150	COG2084	Dehydrogenase
EXH44_RS05155	COG1349	DNA-binding transcription factor activity
EXH44_RS05165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXH44_RS05195	COG1194	a g-specific adenine glycosylase
EXH44_RS05200	COG0346	lactoylglutathione lyase activity
EXH44_RS05210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXH44_RS05210	COG1263	PTS System
EXH44_RS05210	COG2190	(PTS) system
EXH44_RS05230	COG5295	Hep Hag repeat protein
EXH44_RS05230	COG5295	Hep Hag repeat protein
EXH44_RS05230	COG5295	Hep Hag repeat protein
EXH44_RS05240	COG0625	glutathione transferase activity
EXH44_RS05245	COG0019	diaminopimelate decarboxylase activity
EXH44_RS05255	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
EXH44_RS05270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXH44_RS05275	COG2900	Belongs to the SlyX family
EXH44_RS05280	COG0545	Peptidyl-prolyl cis-trans isomerase
EXH44_RS05285	COG2964	Protein conserved in bacteria
EXH44_RS05290	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EXH44_RS05295	COG2923	Belongs to the DsrF TusC family
EXH44_RS05300	COG2168	tRNA wobble position uridine thiolation
EXH44_RS05315	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS05340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXH44_RS05345	COG1879	ABC-type sugar transport system periplasmic component
EXH44_RS05350	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXH44_RS05400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXH44_RS05430	COG0445	tRNA wobble uridine modification
EXH44_RS05435	COG2190	(PTS) system
EXH44_RS05435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXH44_RS05435	COG1263	PTS System
EXH44_RS05440	COG1349	DNA-binding transcription factor activity
EXH44_RS05445	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
EXH44_RS05450	COG1070	Carbohydrate kinase
EXH44_RS05460	COG0235	Class ii aldolase
EXH44_RS05465	COG1129	ABC transporter
EXH44_RS05470	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXH44_RS05475	COG1879	ABC-type sugar transport system periplasmic component
EXH44_RS05480	COG0738	Major facilitator superfamily
EXH44_RS05485	COG1454	alcohol dehydrogenase
EXH44_RS05490	COG1012	belongs to the aldehyde dehydrogenase family
EXH44_RS05500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXH44_RS05505	COG2267	carboxylic ester hydrolase activity
EXH44_RS05510	COG0671	phosphoesterase, PA-phosphatase related
EXH44_RS05510	COG2453	phosphatase
EXH44_RS05525	COG4589	Belongs to the CDS family
EXH44_RS05530	COG2801	Transposase and inactivated derivatives
EXH44_RS05535	COG2963	transposase activity
EXH44_RS05540	COG0247	lactate metabolic process
EXH44_RS05550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXH44_RS05555	COG2271	Major facilitator Superfamily
EXH44_RS05560	COG0584	glycerophosphoryl diester phosphodiesterase
EXH44_RS05565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXH44_RS05570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EXH44_RS05570	COG2221	Nitrite and sulphite reductase 4Fe-4S
EXH44_RS05575	COG3381	protein complex oligomerization
EXH44_RS05580	COG3302	dmso reductase anchor subunit
EXH44_RS05585	COG0437	4 iron, 4 sulfur cluster binding
EXH44_RS05590	COG0243	molybdopterin cofactor binding
EXH44_RS05595	COG0814	amino acid
EXH44_RS05625	COG0737	Belongs to the 5'-nucleotidase family
EXH44_RS05630	COG0716	FMN binding
EXH44_RS05675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXH44_RS05690	COG0859	PFAM glycosyl transferase family 9
EXH44_RS05695	COG0859	PFAM glycosyl transferase family 9
EXH44_RS05705	COG3266	domain, Protein
EXH44_RS05705	COG3061	Opacity-associated protein A
EXH44_RS05710	COG1555	photosystem II stabilization
EXH44_RS05720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXH44_RS05740	COG0204	Acyl-transferase
EXH44_RS05765	COG0730	response to heat
EXH44_RS05770	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXH44_RS05775	COG3119	arylsulfatase activity
EXH44_RS05780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXH44_RS05785	COG0641	radical SAM
EXH44_RS05790	COG0477	Major facilitator Superfamily
EXH44_RS05795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EXH44_RS05805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXH44_RS05815	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXH44_RS05820	COG2832	Protein of unknown function (DUF454)
EXH44_RS05825	COG1215	transferase activity, transferring glycosyl groups
EXH44_RS05830	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EXH44_RS05840	COG0084	hydrolase, TatD family'
EXH44_RS05845	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EXH44_RS05850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXH44_RS05855	COG0686	Belongs to the AlaDH PNT family
EXH44_RS05860	COG0733	neurotransmitter:sodium symporter activity
EXH44_RS05870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXH44_RS05880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXH44_RS05905	COG1487	ribonuclease activity
EXH44_RS05930	COG2050	protein possibly involved in aromatic compounds catabolism
EXH44_RS05935	COG0277	FAD linked oxidase domain protein
EXH44_RS05935	COG0247	lactate metabolic process
EXH44_RS05940	COG2885	chlorophyll binding
EXH44_RS05940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EXH44_RS05945	COG3676	manually curated
EXH44_RS05950	COG2885	chlorophyll binding
EXH44_RS05950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EXH44_RS05955	COG3120	sequence-specific DNA binding
EXH44_RS05960	COG1067	ATP-dependent peptidase activity
EXH44_RS05990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EXH44_RS05995	COG1025	Belongs to the peptidase M16 family
EXH44_RS06005	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXH44_RS06030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXH44_RS06035	COG0594	ribonuclease P activity
EXH44_RS06040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EXH44_RS06045	COG1739	Uncharacterized protein family UPF0029
EXH44_RS06050	COG2358	TRAP transporter, solute receptor (TAXI family
EXH44_RS06070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXH44_RS06075	COG0569	domain protein
EXH44_RS06080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXH44_RS06090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXH44_RS06095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EXH44_RS06100	COG3062	negative regulation of establishment of protein localization
EXH44_RS06110	COG0437	4 iron, 4 sulfur cluster binding
EXH44_RS06115	COG0348	domain, Protein
EXH44_RS06120	COG3043	anaerobic respiration
EXH44_RS06125	COG3005	denitrification pathway
EXH44_RS06130	COG1609	Transcriptional regulator
EXH44_RS06135	COG3265	gluconokinase activity
EXH44_RS06140	COG2610	gluconate transmembrane transporter activity
EXH44_RS06145	COG1694	Mazg nucleotide pyrophosphohydrolase
EXH44_RS06160	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXH44_RS06165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EXH44_RS06170	COG0561	phosphatase activity
EXH44_RS06175	COG2271	Major facilitator Superfamily
EXH44_RS06205	COG0354	folic acid binding
EXH44_RS06255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXH44_RS06260	COG3276	selenocysteine insertion sequence binding
EXH44_RS06275	COG0582	viral genome integration into host DNA
EXH44_RS06360	COG0799	negative regulation of ribosome biogenesis
EXH44_RS06365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXH44_RS06370	COG0768	penicillin binding
EXH44_RS06375	COG0772	Belongs to the SEDS family
EXH44_RS06385	COG1686	Belongs to the peptidase S11 family
EXH44_RS06405	COG0321	lipoyl(octanoyl) transferase activity
EXH44_RS06415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXH44_RS06420	COG1328	CTP reductase activity
EXH44_RS06435	COG0511	ligase activity, forming carbon-carbon bonds
EXH44_RS06440	COG0439	Biotin carboxylase
EXH44_RS06455	COG2897	thiosulfate sulfurtransferase activity
EXH44_RS06460	COG2897	thiosulfate sulfurtransferase activity
EXH44_RS06465	COG2391	methyltransferase activity
EXH44_RS06470	COG3344	reverse transcriptase
EXH44_RS06475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXH44_RS06500	COG0347	Belongs to the P(II) protein family
EXH44_RS06505	COG0004	ammonium transporteR
EXH44_RS06510	COG3590	peptidase
EXH44_RS06530	COG3085	chromosome segregation
EXH44_RS06535	COG1012	belongs to the aldehyde dehydrogenase family
EXH44_RS06535	COG1454	alcohol dehydrogenase
EXH44_RS06550	COG2003	Belongs to the UPF0758 family
EXH44_RS06555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXH44_RS06560	COG1442	glycosyl transferase family 8
EXH44_RS06600	COG1253	flavin adenine dinucleotide binding
EXH44_RS06605	COG0560	Phosphoserine phosphatase
EXH44_RS06620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXH44_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
EXH44_RS06635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXH44_RS06645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXH44_RS06660	COG1943	Transposase
EXH44_RS06665	COG1131	(ABC) transporter
EXH44_RS06670	COG0842	Transport permease protein
EXH44_RS06735	COG1476	TRANSCRIPTIONal
EXH44_RS06760	COG0824	Thioesterase
EXH44_RS06765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXH44_RS06780	COG1399	metal-binding, possibly nucleic acid-binding protein
EXH44_RS06790	COG0416	fatty acid biosynthetic process
EXH44_RS06795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXH44_RS06800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXH44_RS06805	COG3171	Protein conserved in bacteria
EXH44_RS06810	COG0762	integral membrane protein
EXH44_RS06820	COG4137	Cytochrome C assembly protein
EXH44_RS06825	COG4536	flavin adenine dinucleotide binding
EXH44_RS06830	COG0142	geranyltranstransferase activity
EXH44_RS06835	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EXH44_RS06845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXH44_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
EXH44_RS06855	COG1114	Component of the transport system for branched-chain amino acids
EXH44_RS06915	COG2801	Transposase and inactivated derivatives
EXH44_RS06920	COG4221	oxidoreductase activity
EXH44_RS06935	COG0745	RESPONSE REGULATOR receiver
EXH44_RS06940	COG5002	protein histidine kinase activity
EXH44_RS06945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXH44_RS06945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXH44_RS06950	COG3715	PTS system
EXH44_RS06955	COG3716	PTS system mannose fructose sorbose family IID component
EXH44_RS06975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXH44_RS06995	COG1053	succinate dehydrogenase
EXH44_RS07000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXH44_RS07010	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EXH44_RS07015	COG0525	valine-tRNA ligase activity
EXH44_RS07020	COG2153	protein acetylation
EXH44_RS07030	COG2927	DNA polymerase III (CHI subunit)
EXH44_RS07035	COG1388	LysM domain
EXH44_RS07045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXH44_RS07060	COG1045	serine acetyltransferase
EXH44_RS07100	COG0456	acetyltransferase
EXH44_RS07105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXH44_RS07120	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EXH44_RS07165	COG0747	negative chemotaxis
EXH44_RS07175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXH44_RS07185	COG0742	ribosomal rna small subunit methyltransferase
EXH44_RS07190	COG1876	peptidase activity
EXH44_RS07205	COG1393	Belongs to the ArsC family
EXH44_RS07210	COG2059	Chromate
EXH44_RS07215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXH44_RS07225	COG0564	pseudouridine synthase activity
EXH44_RS07230	COG0668	transmembrane transport
EXH44_RS07235	COG1530	ribonuclease E activity
EXH44_RS07250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXH44_RS07255	COG1621	beta-fructofuranosidase activity
EXH44_RS07265	COG0733	neurotransmitter:sodium symporter activity
EXH44_RS07275	COG3012	SEC-C Motif Domain Protein
EXH44_RS07290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXH44_RS07295	COG0805	protein transport
EXH44_RS07305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EXH44_RS07310	COG1349	DNA-binding transcription factor activity
EXH44_RS07315	COG0557	exoribonuclease II activity
EXH44_RS07320	COG1555	photosystem II stabilization
EXH44_RS07320	COG1596	polysaccharide export
EXH44_RS07325	COG4145	pantothenate transmembrane transporter activity
EXH44_RS07330	COG3924	membrane
EXH44_RS07360	COG3681	Belongs to the UPF0597 family
EXH44_RS07365	COG0387	Pfam Sodium calcium exchanger
EXH44_RS07375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EXH44_RS07385	COG4545	Glutaredoxin-related protein
EXH44_RS07390	COG1794	racemase activity, acting on amino acids and derivatives
EXH44_RS07400	COG0363	glucosamine-6-phosphate deaminase activity
EXH44_RS07405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXH44_RS07410	COG1218	3'(2'),5'-bisphosphate nucleotidase
EXH44_RS07420	COG0494	nUDIX hydrolase
EXH44_RS07425	COG1238	metal cluster binding
EXH44_RS07430	COG2116	formate transmembrane transporter activity
EXH44_RS07435	COG1882	Formate acetyltransferase
EXH44_RS07440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EXH44_RS07445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXH44_RS07450	COG2932	Transcriptional regulator
EXH44_RS07455	COG0791	NLP P60 protein
EXH44_RS07465	COG3381	protein complex oligomerization
EXH44_RS07470	COG0070	glutamate synthase
EXH44_RS07470	COG0067	glutamate synthase
EXH44_RS07470	COG0069	glutamate synthase activity
EXH44_RS07475	COG0493	'glutamate synthase
EXH44_RS07480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EXH44_RS07490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EXH44_RS07495	COG0024	Methionine aminopeptidase
EXH44_RS07505	COG0745	RESPONSE REGULATOR receiver
EXH44_RS07510	COG0295	cytidine deaminase activity
EXH44_RS07515	COG0697	spore germination
EXH44_RS07520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXH44_RS07540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXH44_RS07555	COG2909	trisaccharide binding
EXH44_RS07595	COG0475	glutathione-regulated potassium exporter activity
EXH44_RS07595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXH44_RS07600	COG1138	Cytochrome C-type biogenesis protein
EXH44_RS07610	COG3088	subunit of a heme lyase
EXH44_RS07610	COG4235	cytochrome complex assembly
EXH44_RS07615	COG3088	subunit of a heme lyase
EXH44_RS07615	COG4235	cytochrome complex assembly
EXH44_RS07630	COG3099	Belongs to the UPF0263 family
EXH44_RS07635	COG3676	manually curated
EXH44_RS07640	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EXH44_RS07645	COG2835	tetraacyldisaccharide 4'-kinase activity
EXH44_RS07650	COG1663	tetraacyldisaccharide 4'-kinase activity
EXH44_RS07655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EXH44_RS07665	COG2166	iron-sulfur cluster assembly
EXH44_RS07670	COG3063	Type IV pilus biogenesis stability protein PilW
EXH44_RS07720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EXH44_RS07720	COG1017	nitric oxide dioxygenase activity
EXH44_RS07725	COG1959	2 iron, 2 sulfur cluster binding
EXH44_RS07730	COG1322	Protein conserved in bacteria
EXH44_RS07735	COG0512	Glutamine amidotransferase of anthranilate synthase
EXH44_RS07745	COG1230	cation diffusion facilitator family transporter
EXH44_RS07760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXH44_RS07770	COG2137	regulation of response to DNA damage stimulus
EXH44_RS07780	COG0551	DNA topoisomerase type I activity
EXH44_RS07815	COG2960	long-chain fatty acid transporting porin activity
EXH44_RS07825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXH44_RS07835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EXH44_RS07850	COG0131	Imidazoleglycerol-phosphate dehydratase
EXH44_RS07850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXH44_RS07855	COG3739	integral membrane protein
EXH44_RS07870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXH44_RS07880	COG0107	imidazoleglycerol-phosphate synthase activity
EXH44_RS07885	COG0140	phosphoribosyl-ATP diphosphatase activity
EXH44_RS07885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EXH44_RS07890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXH44_RS07910	COG1138	Cytochrome C-type biogenesis protein
EXH44_RS07920	COG2223	nitrite transmembrane transporter activity
EXH44_RS07935	COG0583	DNA-binding transcription factor activity
EXH44_RS07940	COG2259	Doxx family
EXH44_RS07955	COG0798	PFAM Bile acid sodium symporter
EXH44_RS07960	COG1162	GTPase activity
EXH44_RS07970	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS07975	COG1121	(ABC) transporter
EXH44_RS07980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXH44_RS07985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXH44_RS07990	COG0534	Mate efflux family protein
EXH44_RS07995	COG0564	pseudouridine synthase activity
EXH44_RS08000	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EXH44_RS08015	COG3639	organic phosphonate transmembrane transporter activity
EXH44_RS08020	COG3639	organic phosphonate transmembrane transporter activity
EXH44_RS08045	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXH44_RS08055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXH44_RS08060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXH44_RS08065	COG2032	superoxide dismutase activity
EXH44_RS08070	COG4591	ABC-type transport system involved in lipoprotein release permease component
EXH44_RS08075	COG2364	Membrane
EXH44_RS08085	COG0316	Belongs to the HesB IscA family
EXH44_RS08085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXH44_RS08095	COG1805	sodium ion transport
EXH44_RS08100	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EXH44_RS08105	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EXH44_RS08115	COG2871	sodium ion transport
EXH44_RS08120	COG1477	protein flavinylation
EXH44_RS08125	COG2991	Protein conserved in bacteria
EXH44_RS08140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXH44_RS08160	COG2965	DNA replication, synthesis of RNA primer
EXH44_RS08175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXH44_RS08195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EXH44_RS08205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXH44_RS08230	COG0058	SHG alpha-glucan phosphorylase activity
EXH44_RS08240	COG0561	phosphatase activity
EXH44_RS08245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EXH44_RS08255	COG1965	Belongs to the frataxin family
EXH44_RS08265	COG2259	Doxx family
EXH44_RS08275	COG3220	belongs to the UPF0276 family
EXH44_RS08280	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS08290	COG2826	transposase and inactivated derivatives, IS30 family
EXH44_RS08300	COG3219	Protein conserved in bacteria
EXH44_RS08305	COG1595	DNA-templated transcription, initiation
EXH44_RS08320	COG0385	Bile acid
EXH44_RS08330	COG3978	acetolactate synthase activity
EXH44_RS08340	COG3676	manually curated
EXH44_RS08355	COG4143	(ABC) transporter
EXH44_RS08360	COG1702	phosphate starvation-inducible protein PhoH
EXH44_RS08365	COG0673	inositol 2-dehydrogenase activity
EXH44_RS08380	COG2252	PERMEase
EXH44_RS08385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXH44_RS08390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXH44_RS08395	COG5413	integral membrane protein
EXH44_RS08415	COG0339	signal peptide processing
EXH44_RS08425	COG1605	Chorismate mutase
EXH44_RS08425	COG0077	Prephenate dehydratase
EXH44_RS08440	COG2814	Major facilitator Superfamily
EXH44_RS08445	COG0513	Belongs to the DEAD box helicase family
EXH44_RS08450	COG0456	acetyltransferase
EXH44_RS08500	COG1408	metallophosphoesterase
EXH44_RS08505	COG0753	catalase activity
EXH44_RS08525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXH44_RS08530	COG3842	ATPase activity
EXH44_RS08535	COG1446	asparaginase
EXH44_RS08550	COG2017	converts alpha-aldose to the beta-anomer
EXH44_RS08560	COG1085	galactose-1-phosphate uridylyltransferase
EXH44_RS08565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXH44_RS08570	COG0330	HflC and HflK could
EXH44_RS08600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXH44_RS08620	COG0436	Aminotransferase
EXH44_RS08625	COG1169	isochorismate synthase
EXH44_RS08630	COG4232	protein-disulfide reductase activity
EXH44_RS08635	COG0300	oxidoreductase activity
EXH44_RS08640	COG2431	L-lysine efflux transmembrane transporter activity
EXH44_RS08660	COG3069	C4-dicarboxylate transmembrane transporter activity
EXH44_RS08665	COG1473	amidohydrolase
EXH44_RS08675	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EXH44_RS08680	COG0628	permease
EXH44_RS08690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXH44_RS08700	COG0330	HflC and HflK could
EXH44_RS08705	COG0330	HflC and HflK could
EXH44_RS08725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EXH44_RS08730	COG0471	metal ion transport
EXH44_RS08735	COG1388	LysM domain
EXH44_RS08735	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXH44_RS08740	COG0802	atpase or kinase
EXH44_RS08745	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EXH44_RS08755	COG1519	Transferase
EXH44_RS08765	COG0795	lipopolysaccharide-transporting ATPase activity
EXH44_RS08770	COG0795	lipopolysaccharide-transporting ATPase activity
EXH44_RS08785	COG3842	ATPase activity
EXH44_RS08795	COG1840	ABC-type Fe3 transport system, periplasmic component
EXH44_RS08800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXH44_RS08815	COG1230	cation diffusion facilitator family transporter
EXH44_RS08830	COG2878	Part of a membrane complex involved in electron transport
EXH44_RS08835	COG4656	Part of a membrane complex involved in electron transport
EXH44_RS08860	COG1560	Kdo2-lipid A biosynthetic process
EXH44_RS08865	COG2226	methyltransferase
EXH44_RS08870	COG1252	NADH dehydrogenase
EXH44_RS08880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EXH44_RS08885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EXH44_RS08900	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXH44_RS08905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EXH44_RS08910	COG0194	GDP metabolic process
EXH44_RS08915	COG1538	Outer membrane efflux protein
EXH44_RS08920	COG0301	tRNA thio-modification
EXH44_RS08920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXH44_RS08925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXH44_RS08930	COG5039	Polysaccharide pyruvyl transferase
EXH44_RS08935	COG1083	cytidylyl-transferase
EXH44_RS08950	COG3306	glycosyltransferase involved in LPS biosynthesis
EXH44_RS08960	COG1216	Glycosyl transferase, family 2
EXH44_RS08965	COG1216	Glycosyl transferase, family 2
EXH44_RS08970	COG0424	maF-like protein
EXH44_RS08975	COG1466	dna polymerase III delta subunit
EXH44_RS08980	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EXH44_RS08985	COG0495	leucyl-tRNA aminoacylation
EXH44_RS08990	COG0425	Belongs to the sulfur carrier protein TusA family
EXH44_RS08995	COG2391	methyltransferase activity
EXH44_RS09010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EXH44_RS09015	COG0488	(ABC) transporter
EXH44_RS09020	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EXH44_RS09025	COG0564	pseudouridine synthase activity
EXH44_RS09035	COG4172	Belongs to the ABC transporter superfamily
EXH44_RS09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXH44_RS09045	COG0601	transmembrane transport
EXH44_RS09050	COG0747	negative chemotaxis
EXH44_RS09065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXH44_RS09075	COG2999	glutathione oxidoreductase activity
EXH44_RS09085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXH44_RS09090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EXH44_RS09095	COG0848	biopolymer transport protein
EXH44_RS09100	COG0811	peptide transport
EXH44_RS09110	COG0616	signal peptide processing
EXH44_RS09115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXH44_RS09140	COG0861	Integral membrane protein TerC family
EXH44_RS09155	COG1027	Aspartate ammonia-lyase
EXH44_RS09160	COG3111	PFAM Bacterial OB fold (BOF) protein
EXH44_RS09165	COG3111	PFAM Bacterial OB fold (BOF) protein
EXH44_RS09170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXH44_RS09180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXH44_RS09185	COG0617	tRNA 3'-terminal CCA addition
EXH44_RS09190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXH44_RS09200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXH44_RS09205	COG0402	S-adenosylhomocysteine deaminase activity
EXH44_RS09210	COG3023	N-Acetylmuramoyl-L-alanine amidase
EXH44_RS09215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EXH44_RS09225	COG1929	Belongs to the glycerate kinase type-1 family
EXH44_RS09235	COG4120	Belongs to the binding-protein-dependent transport system permease family
EXH44_RS09270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EXH44_RS09275	COG1595	DNA-templated transcription, initiation
EXH44_RS09280	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
EXH44_RS09285	COG3025	triphosphatase activity
EXH44_RS09305	COG0564	pseudouridine synthase activity
EXH44_RS09310	COG3098	single-species biofilm formation
EXH44_RS09315	COG0135	phosphoribosylanthranilate isomerase activity
EXH44_RS09315	COG0134	indole-3-glycerol-phosphate synthase activity
EXH44_RS09320	COG1199	ATP-dependent helicase activity
EXH44_RS09325	COG1380	Effector of murein hydrolase LrgA
EXH44_RS09330	COG1346	cytolysis
EXH44_RS09350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXH44_RS09365	COG0582	viral genome integration into host DNA
EXH44_RS09375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EXH44_RS09380	COG4149	molybdate abc transporter
EXH44_RS09385	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXH44_RS09390	COG2005	Transcriptional regulator
EXH44_RS09395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXH44_RS09425	COG1943	Transposase
EXH44_RS09440	COG3676	manually curated
EXH44_RS09470	COG0681	Belongs to the peptidase S26 family
EXH44_RS09495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXH44_RS09500	COG1917	Cupin 2, conserved barrel domain protein
EXH44_RS09500	COG4977	sequence-specific DNA binding
EXH44_RS09505	COG3302	dmso reductase anchor subunit
EXH44_RS09510	COG0437	4 iron, 4 sulfur cluster binding
EXH44_RS09515	COG0243	molybdopterin cofactor binding
EXH44_RS09520	COG0697	spore germination
EXH44_RS09525	COG2949	membrane
EXH44_RS09530	COG1757	Na H antiporter
EXH44_RS09535	COG2916	Histone family protein nucleoid-structuring protein H-NS
EXH44_RS09540	COG0788	formyltetrahydrofolate deformylase activity
EXH44_RS09550	COG0747	negative chemotaxis
EXH44_RS09560	COG0444	Belongs to the ABC transporter superfamily
EXH44_RS09565	COG4608	Belongs to the ABC transporter superfamily
EXH44_RS09570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXH44_RS09575	COG1286	toxin biosynthetic process
EXH44_RS09580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXH44_RS09590	COG0183	Belongs to the thiolase family
EXH44_RS09605	COG1944	ATP diphosphatase activity
EXH44_RS09610	COG1530	ribonuclease E activity
EXH44_RS09615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXH44_RS09625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EXH44_RS09630	COG1137	ATPase activity
EXH44_RS09635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXH44_RS09640	COG1660	Displays ATPase and GTPase activities
EXH44_RS09645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXH44_RS09670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EXH44_RS09675	COG0083	homoserine kinase activity
EXH44_RS09680	COG0460	homoserine dehydrogenase
EXH44_RS09680	COG0527	aspartate kinase activity
EXH44_RS09695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXH44_RS09760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EXH44_RS09765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EXH44_RS09795	COG3683	transport system, periplasmic component
EXH44_RS09800	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EXH44_RS09805	COG1115	amino acid carrier protein
EXH44_RS09810	COG4206	TonB-dependent receptor
EXH44_RS09820	COG4139	cobalamin transport
EXH44_RS09830	COG3106	COG3106 Predicted ATPase
EXH44_RS09835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXH44_RS09840	COG0709	Synthesizes selenophosphate from selenide and ATP
EXH44_RS09845	COG2867	negative regulation of translational initiation
EXH44_RS09850	COG2914	Belongs to the UPF0125 (RnfH) family
EXH44_RS09860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EXH44_RS09860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXH44_RS09865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXH44_RS09870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXH44_RS09880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXH44_RS09885	COG0303	'Molybdopterin
EXH44_RS09890	COG2095	MarC family integral membrane protein
EXH44_RS09910	COG1441	menaquinone biosynthetic process
EXH44_RS09920	COG0251	oxidation-reduction process
EXH44_RS09930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EXH44_RS09935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXH44_RS09940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EXH44_RS09950	COG0058	SHG alpha-glucan phosphorylase activity
EXH44_RS09955	COG0741	lytic transglycosylase activity
EXH44_RS09960	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXH44_RS09980	COG0786	glutamate:sodium symporter activity
EXH44_RS10010	COG0084	hydrolase, TatD family'
EXH44_RS10015	COG0542	response to heat
EXH44_RS10025	COG1373	ATPase (AAA superfamily
EXH44_RS10035	COG3645	SOS response
EXH44_RS10060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXH44_RS10070	COG1373	ATPase (AAA superfamily
EXH44_RS10085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EXH44_RS10105	COG0670	Belongs to the BI1 family
EXH44_RS10110	COG2920	part of a sulfur-relay system
EXH44_RS10115	COG0859	PFAM glycosyl transferase family 9
EXH44_RS10120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EXH44_RS10125	COG0287	Prephenate dehydrogenase
EXH44_RS10125	COG1605	Chorismate mutase
EXH44_RS10140	COG2814	Major facilitator Superfamily
EXH44_RS10145	COG1187	pseudouridine synthase activity
EXH44_RS10150	COG2095	MarC family integral membrane protein
EXH44_RS10155	COG4166	transmembrane transport
EXH44_RS10160	COG0489	protein tyrosine kinase activity
EXH44_RS10165	COG3787	Belongs to the UPF0306 family
EXH44_RS10175	COG0037	tRNA processing
EXH44_RS10180	COG2056	Na+-H+ antiporter family
EXH44_RS10185	COG0708	Exodeoxyribonuclease III
EXH44_RS10190	COG0814	amino acid
EXH44_RS10195	COG1522	sequence-specific DNA binding
EXH44_RS10200	COG1674	ftsk spoiiie
EXH44_RS10205	COG2321	neutral zinc metallopeptidase
EXH44_RS10210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EXH44_RS10215	COG1214	PFAM Peptidase M22, glycoprotease
EXH44_RS10235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXH44_RS10240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EXH44_RS10245	COG1309	transcriptional regulator
EXH44_RS10260	COG3676	manually curated
EXH44_RS10270	COG3112	Uncharacterised protein family (UPF0231)
EXH44_RS10275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXH44_RS10280	COG0629	single-stranded DNA binding
EXH44_RS10315	COG0798	PFAM Bile acid sodium symporter
EXH44_RS10320	COG0789	Transcriptional regulator
EXH44_RS10330	COG0789	Transcriptional regulator
EXH44_RS10345	COG2217	Heavy metal translocating P-type atpase
EXH44_RS10360	COG2132	Multicopper oxidase
EXH44_RS10375	COG0745	RESPONSE REGULATOR receiver
EXH44_RS10380	COG5002	protein histidine kinase activity
EXH44_RS10430	COG0288	reversible hydration of carbon dioxide
EXH44_RS10435	COG1278	Cold shock
EXH44_RS10455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXH44_RS10465	COG0189	ligase activity
EXH44_RS10475	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EXH44_RS10490	COG0626	cystathionine gamma-synthase activity
EXH44_RS10495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXH44_RS10505	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXH44_RS10510	COG0567	Dehydrogenase, E1 component
EXH44_RS10520	COG0572	uridine kinase
EXH44_RS10530	COG0814	amino acid
EXH44_RS10550	COG4991	sh3 domain protein
EXH44_RS10555	COG0306	phosphate transporter
EXH44_RS10560	COG1392	Phosphate transport regulator
EXH44_RS10580	COG0791	NLP P60 protein
EXH44_RS10585	COG0586	Pfam SNARE associated Golgi protein
EXH44_RS10595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXH44_RS10595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EXH44_RS10600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EXH44_RS10625	COG0513	Belongs to the DEAD box helicase family
EXH44_RS10630	COG0433	COG0433 Predicted ATPase
EXH44_RS10635	COG1840	ABC-type Fe3 transport system, periplasmic component
EXH44_RS10650	COG3676	manually curated
EXH44_RS10660	COG3083	sulfuric ester hydrolase activity
EXH44_RS10670	COG2226	methyltransferase
EXH44_RS10675	COG0187	DNA topoisomerase II activity
EXH44_RS10685	COG3945	hemerythrin HHE cation binding domain
EXH44_RS10700	COG3842	ATPase activity
EXH44_RS10715	COG3955	Domain of unknown function (DUF1919)
EXH44_RS10725	COG0516	GMP reductase activity
EXH44_RS10725	COG0517	IMP dehydrogenase activity
EXH44_RS10735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXH44_RS10740	COG1523	belongs to the glycosyl hydrolase 13 family
EXH44_RS10745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXH44_RS10750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXH44_RS10765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXH44_RS10775	COG3676	manually curated
EXH44_RS10780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXH44_RS10780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXH44_RS10785	COG0440	acetolactate synthase activity
EXH44_RS10790	COG0028	Belongs to the TPP enzyme family
EXH44_RS10795	COG0280	phosphate acetyltransferase
EXH44_RS10795	COG0281	malic enzyme
EXH44_RS10815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXH44_RS10835	COG0195	Participates in both transcription termination and antitermination
EXH44_RS10840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXH44_RS10850	COG1566	PFAM secretion protein HlyD family protein
EXH44_RS10855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXH44_RS10865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EXH44_RS10870	COG2951	lytic endotransglycosylase activity
EXH44_RS10875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EXH44_RS10880	COG3105	Protein conserved in bacteria
EXH44_RS10895	COG3344	reverse transcriptase
EXH44_RS10915	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EXH44_RS10920	COG0328	RNA-DNA hybrid ribonuclease activity
EXH44_RS10935	COG3676	manually curated
EXH44_RS10975	COG2731	YhcH YjgK YiaL family protein
EXH44_RS10980	COG1737	Transcriptional regulator