locus-tag	class	description
IOD66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IOD66_RS00010	COG0592	DNA-directed DNA polymerase activity
IOD66_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD66_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD66_RS00035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_RS00040	COG0616	signal peptide processing
IOD66_RS00045	COG2001	Belongs to the MraZ family
IOD66_RS00050	COG0275	rRNA processing
IOD66_RS00055	COG3116	cell division
IOD66_RS00060	COG0768	penicillin binding
IOD66_RS00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOD66_RS00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOD66_RS00075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD66_RS00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IOD66_RS00085	COG0772	Belongs to the SEDS family
IOD66_RS00090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IOD66_RS00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD66_RS00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD66_RS00110	COG0849	cell division
IOD66_RS00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOD66_RS00120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IOD66_RS00125	COG0497	DNA recombination
IOD66_RS00130	COG4172	Belongs to the ABC transporter superfamily
IOD66_RS00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD66_RS00140	COG0601	transmembrane transport
IOD66_RS00150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IOD66_RS00265	COG2003	Belongs to the UPF0758 family
IOD66_RS00290	COG0714	Associated with various cellular activities
IOD66_RS00310	COG0629	single-stranded DNA binding
IOD66_RS00325	COG0789	Transcriptional regulator
IOD66_RS00380	COG1902	pentaerythritol trinitrate reductase activity
IOD66_RS00420	COG0789	Transcriptional regulator
IOD66_RS00440	COG2356	endonuclease I
IOD66_RS00470	COG0681	Belongs to the peptidase S26 family
IOD66_RS00485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_RS00535	COG1484	DNA-dependent DNA replication
IOD66_RS00550	COG4584	PFAM Integrase catalytic
IOD66_RS00595	COG1401	restriction endodeoxyribonuclease activity
IOD66_RS00600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD66_RS00615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IOD66_RS00640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD66_RS00725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD66_RS00785	COG0193	aminoacyl-tRNA hydrolase activity
IOD66_RS00790	COG0012	GTP binding
IOD66_RS00795	COG2020	methyltransferase activity
IOD66_RS00805	COG3133	Outer membrane lipoprotein
IOD66_RS00810	COG3102	Protein conserved in bacteria
IOD66_RS00815	COG0018	arginyl-trna synthetase
IOD66_RS00820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IOD66_RS00830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD66_RS00835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD66_RS00840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOD66_RS00845	COG0196	riboflavin kinase activity
IOD66_RS00850	COG3172	ATPase kinase involved in NAD metabolism
IOD66_RS00855	COG2129	metallophosphoesterase
IOD66_RS00860	COG0745	RESPONSE REGULATOR receiver
IOD66_RS00875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IOD66_RS00880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IOD66_RS00885	COG1217	gtp-binding protein TYPA
IOD66_RS00890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD66_RS00895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IOD66_RS00900	COG1561	YicC-like family, N-terminal region
IOD66_RS00905	COG0354	folic acid binding
IOD66_RS00910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD66_RS00915	COG2197	response regulator
IOD66_RS00920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IOD66_RS00920	COG0116	Belongs to the methyltransferase superfamily
IOD66_RS00925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOD66_RS00960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IOD66_RS00965	COG4133	protoheme IX ABC transporter activity
IOD66_RS00970	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD66_RS00975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD66_RS00980	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD66_RS00985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IOD66_RS00990	COG1138	Cytochrome C-type biogenesis protein
IOD66_RS01010	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IOD66_RS01025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IOD66_RS01030	COG0792	nuclease activity
IOD66_RS01035	COG3107	peptidoglycan biosynthetic process
IOD66_RS01045	COG3101	peptidyl-lysine hydroxylation
IOD66_RS01050	COG4232	protein-disulfide reductase activity
IOD66_RS01060	COG3620	sequence-specific DNA binding
IOD66_RS01070	COG1881	PFAM PEBP family protein
IOD66_RS01075	COG1126	abc transporter atp-binding protein
IOD66_RS01080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD66_RS01085	COG4215	(ABC) transporter
IOD66_RS01090	COG4160	amino acid transport
IOD66_RS01100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD66_RS01105	COG3099	Belongs to the UPF0263 family
IOD66_RS01110	COG0742	ribosomal rna small subunit methyltransferase
IOD66_RS01115	COG0552	protein localization to endoplasmic reticulum
IOD66_RS01120	COG2884	Cell division ATP-binding protein ftsE
IOD66_RS01125	COG2177	Part of the ABC transporter FtsEX involved in
IOD66_RS01130	COG0295	cytidine deaminase activity
IOD66_RS01135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD66_RS01140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IOD66_RS01145	COG0308	aminopeptidase N
IOD66_RS01150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOD66_RS01190	COG0375	protein maturation
IOD66_RS01195	COG0298	carbon dioxide binding
IOD66_RS01200	COG1773	rubredoxin
IOD66_RS01205	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IOD66_RS01210	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IOD66_RS01215	COG5557	Pfam Polysulphide reductase, NrfD
IOD66_RS01220	COG0437	4 iron, 4 sulfur cluster binding
IOD66_RS01225	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IOD66_RS01230	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOD66_RS01235	COG0309	Hydrogenase expression formation protein (HypE)
IOD66_RS01240	COG0409	Hydrogenase expression formation protein
IOD66_RS01245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD66_RS01250	COG0210	DNA helicase
IOD66_RS01255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD66_RS01260	COG2190	(PTS) system
IOD66_RS01265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD66_RS01270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_RS01275	COG1178	ABC-type Fe3 transport system permease component
IOD66_RS01280	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IOD66_RS01290	COG0549	Belongs to the carbamate kinase family
IOD66_RS01295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IOD66_RS01300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD66_RS01305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IOD66_RS01310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOD66_RS01315	COG0494	nUDIX hydrolase
IOD66_RS01320	COG1218	3'(2'),5'-bisphosphate nucleotidase
IOD66_RS01325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IOD66_RS01330	COG0363	glucosamine-6-phosphate deaminase activity
IOD66_RS01335	COG2814	Major facilitator Superfamily
IOD66_RS01350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IOD66_RS01365	COG3115	cell septum assembly
IOD66_RS01370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD66_RS01380	COG2814	Major facilitator Superfamily
IOD66_RS01390	COG0563	adenylate kinase activity
IOD66_RS01400	COG0039	L-malate dehydrogenase activity
IOD66_RS01405	COG1438	arginine binding
IOD66_RS01410	COG1090	epimerase
IOD66_RS01415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD66_RS01420	COG1127	ABC transporter
IOD66_RS01425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOD66_RS01430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOD66_RS01435	COG2854	intermembrane phospholipid transfer
IOD66_RS01445	COG5007	Belongs to the BolA IbaG family
IOD66_RS01450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOD66_RS01465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD66_RS01470	COG0488	(ABC) transporter
IOD66_RS01490	COG2166	iron-sulfur cluster assembly
IOD66_RS01495	COG0740	serine-type endopeptidase activity
IOD66_RS01500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IOD66_RS01505	COG1663	tetraacyldisaccharide 4'-kinase activity
IOD66_RS01510	COG2835	tetraacyldisaccharide 4'-kinase activity
IOD66_RS01515	COG4115	mRNA cleavage
IOD66_RS01520	COG2161	toxin-antitoxin pair type II binding
IOD66_RS01555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IOD66_RS01560	COG3063	Type IV pilus biogenesis stability protein PilW
IOD66_RS01565	COG2183	response to ionizing radiation
IOD66_RS01570	COG1252	NADH dehydrogenase
IOD66_RS01580	COG3719	Belongs to the RNase T2 family
IOD66_RS01585	COG0616	signal peptide processing
IOD66_RS01590	COG0778	Nitroreductase
IOD66_RS01595	COG0300	oxidoreductase activity
IOD66_RS01605	COG2217	Heavy metal translocating P-type atpase
IOD66_RS01615	COG0789	Transcriptional regulator
IOD66_RS01640	COG0745	RESPONSE REGULATOR receiver
IOD66_RS01645	COG5002	protein histidine kinase activity
IOD66_RS01650	COG0187	DNA topoisomerase II activity
IOD66_RS01655	COG0471	metal ion transport
IOD66_RS01660	COG0471	metal ion transport
IOD66_RS01665	COG0471	metal ion transport
IOD66_RS01670	COG0126	phosphoglycerate kinase activity
IOD66_RS01675	COG0191	fructose-bisphosphate aldolase activity
IOD66_RS01680	COG4172	Belongs to the ABC transporter superfamily
IOD66_RS01695	COG0778	Nitroreductase
IOD66_RS01710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD66_RS01715	COG0084	hydrolase, TatD family'
IOD66_RS01720	COG1966	Carbon starvation protein
IOD66_RS01725	COG1640	4-alpha-glucanotransferase
IOD66_RS01730	COG3833	ABC-type maltose transport systems, permease component
IOD66_RS01745	COG3842	ATPase activity
IOD66_RS01750	COG4580	involved in the transport of maltose and maltodextrins
IOD66_RS01760	COG2909	trisaccharide binding
IOD66_RS01765	COG0058	SHG alpha-glucan phosphorylase activity
IOD66_RS01775	COG1666	GTP binding
IOD66_RS01780	COG0560	Phosphoserine phosphatase
IOD66_RS01790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IOD66_RS01800	COG2081	HI0933 family
IOD66_RS01805	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOD66_RS01810	COG2252	PERMEase
IOD66_RS01815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD66_RS01820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD66_RS01830	COG0716	FMN binding
IOD66_RS01835	COG0735	belongs to the Fur family
IOD66_RS01840	COG3008	intermembrane lipid transfer
IOD66_RS01845	COG1854	S-ribosylhomocysteine lyase activity
IOD66_RS01850	COG1132	(ABC) transporter
IOD66_RS01860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD66_RS01865	COG1275	C4-dicarboxylate transporter malic acid transport protein
IOD66_RS01880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD66_RS01885	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IOD66_RS01900	COG0625	glutathione transferase activity
IOD66_RS01930	COG2095	MarC family integral membrane protein
IOD66_RS01935	COG0778	Nitroreductase
IOD66_RS01940	COG2084	Dehydrogenase
IOD66_RS01945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD66_RS01965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD66_RS01970	COG1902	pentaerythritol trinitrate reductase activity
IOD66_RS02015	COG1373	ATPase (AAA superfamily
IOD66_RS02020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD66_RS02020	COG0475	glutathione-regulated potassium exporter activity
IOD66_RS02025	COG0673	inositol 2-dehydrogenase activity
IOD66_RS02030	COG0165	Argininosuccinate lyase
IOD66_RS02035	COG0659	secondary active sulfate transmembrane transporter activity
IOD66_RS02040	COG1426	Protein conserved in bacteria
IOD66_RS02045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IOD66_RS02055	COG2976	Protein conserved in bacteria
IOD66_RS02060	COG3201	nicotinamide mononucleotide transporter
IOD66_RS02075	COG2965	DNA replication, synthesis of RNA primer
IOD66_RS02085	COG0359	binds to the 23S rRNA
IOD66_RS02090	COG2841	Protein conserved in bacteria
IOD66_RS02095	COG2268	Band 7 protein
IOD66_RS02100	COG2226	methyltransferase
IOD66_RS02105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD66_RS02110	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD66_RS02115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD66_RS02120	COG2837	iron assimilation
IOD66_RS02130	COG0009	L-threonylcarbamoyladenylate synthase
IOD66_RS02135	COG1187	pseudouridine synthase activity
IOD66_RS02140	COG3266	domain, Protein
IOD66_RS02145	COG0583	DNA-binding transcription factor activity
IOD66_RS02155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD66_RS02160	COG0612	Peptidase, M16
IOD66_RS02165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IOD66_RS02175	COG0217	transcriptional regulatory protein
IOD66_RS02180	COG0494	nUDIX hydrolase
IOD66_RS02185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IOD66_RS02195	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD66_RS02200	COG1322	Protein conserved in bacteria
IOD66_RS02200	COG1322	Protein conserved in bacteria
IOD66_RS02210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD66_RS02215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IOD66_RS02220	COG2137	regulation of response to DNA damage stimulus
IOD66_RS02230	COG0551	DNA topoisomerase type I activity
IOD66_RS02240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD66_RS02265	COG2960	long-chain fatty acid transporting porin activity
IOD66_RS02270	COG0166	Belongs to the GPI family
IOD66_RS02275	COG1388	LysM domain
IOD66_RS02275	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD66_RS02280	COG0802	atpase or kinase
IOD66_RS02285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IOD66_RS02290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IOD66_RS02295	COG1519	Transferase
IOD66_RS02300	COG3307	-O-antigen
IOD66_RS02305	COG0826	peptidase U32
IOD66_RS02315	COG0628	permease
IOD66_RS02320	COG1115	amino acid carrier protein
IOD66_RS02325	COG1525	nuclease
IOD66_RS02330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD66_RS02335	COG0205	6-phosphofructokinase activity
IOD66_RS02345	COG0564	pseudouridine synthase activity
IOD66_RS02350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD66_RS02355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IOD66_RS02365	COG1965	Belongs to the frataxin family
IOD66_RS02375	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
IOD66_RS02380	COG1051	belongs to the nudix hydrolase family
IOD66_RS02385	COG0148	phosphopyruvate hydratase activity
IOD66_RS02390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD66_RS02395	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD66_RS02400	COG0861	Integral membrane protein TerC family
IOD66_RS02405	COG3066	DNA modification
IOD66_RS02410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD66_RS02415	COG2937	Belongs to the GPAT DAPAT family
IOD66_RS02420	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IOD66_RS02430	COG0795	lipopolysaccharide-transporting ATPase activity
IOD66_RS02435	COG0795	lipopolysaccharide-transporting ATPase activity
IOD66_RS02445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IOD66_RS02460	COG0602	queuosine metabolic process
IOD66_RS02465	COG0720	synthase
IOD66_RS02475	COG3583	domain protein
IOD66_RS02475	COG3064	Membrane
IOD66_RS02475	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IOD66_RS02480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IOD66_RS02485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD66_RS02500	COG1027	Aspartate ammonia-lyase
IOD66_RS02510	COG1393	Belongs to the ArsC family
IOD66_RS02515	COG0798	PFAM Bile acid sodium symporter
IOD66_RS02520	COG0542	response to heat
IOD66_RS02525	COG3047	cAMP biosynthetic process
IOD66_RS02540	COG0531	amino acid
IOD66_RS02545	COG0531	amino acid
IOD66_RS02555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IOD66_RS02565	COG3118	belongs to the thioredoxin family
IOD66_RS02570	COG0330	HflC and HflK could
IOD66_RS02575	COG0330	HflC and HflK could
IOD66_RS02580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOD66_RS02585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD66_RS02585	COG0301	tRNA thio-modification
IOD66_RS02595	COG0424	maF-like protein
IOD66_RS02600	COG2252	PERMEase
IOD66_RS02605	COG1528	Iron-storage protein
IOD66_RS02610	COG1528	Iron-storage protein
IOD66_RS02615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD66_RS02620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD66_RS02625	COG1862	Preprotein translocase
IOD66_RS02630	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IOD66_RS02635	COG0642	Histidine kinase
IOD66_RS02640	COG0745	RESPONSE REGULATOR receiver
IOD66_RS02660	COG3111	PFAM Bacterial OB fold (BOF) protein
IOD66_RS02670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD66_RS02680	COG0475	glutathione-regulated potassium exporter activity
IOD66_RS02680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD66_RS02685	COG1138	Cytochrome C-type biogenesis protein
IOD66_RS02690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD66_RS02695	COG3088	subunit of a heme lyase
IOD66_RS02695	COG4235	cytochrome complex assembly
IOD66_RS02705	COG0748	coenzyme F420 binding
IOD66_RS02710	COG4771	TonB-dependent receptor
IOD66_RS02710	COG1629	transport
IOD66_RS02715	COG1280	lysine exporter protein (LysE YggA)
IOD66_RS02720	COG2962	Rard protein
IOD66_RS02725	COG2962	Rard protein
IOD66_RS02730	COG0436	Aminotransferase
IOD66_RS02735	COG1169	isochorismate synthase
IOD66_RS02740	COG2431	L-lysine efflux transmembrane transporter activity
IOD66_RS02745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD66_RS02750	COG0501	Belongs to the peptidase M48B family
IOD66_RS02755	COG1238	metal cluster binding
IOD66_RS02760	COG2116	formate transmembrane transporter activity
IOD66_RS02765	COG1882	Formate acetyltransferase
IOD66_RS02770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD66_RS02775	COG0339	signal peptide processing
IOD66_RS02780	COG0077	Prephenate dehydratase
IOD66_RS02780	COG1605	Chorismate mutase
IOD66_RS02785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOD66_RS02790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD66_RS02795	COG5039	Polysaccharide pyruvyl transferase
IOD66_RS02805	COG3306	glycosyltransferase involved in LPS biosynthesis
IOD66_RS02815	COG1216	Glycosyl transferase, family 2
IOD66_RS02820	COG1216	Glycosyl transferase, family 2
IOD66_RS02825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD66_RS02825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD66_RS02835	COG2186	Transcriptional regulator
IOD66_RS02845	COG1904	glucuronate isomerase
IOD66_RS02850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD66_RS02855	COG0800	Aldolase
IOD66_RS02860	COG2364	Membrane
IOD66_RS02865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD66_RS02870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IOD66_RS02875	COG0813	purine-nucleoside phosphorylase activity
IOD66_RS02880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IOD66_RS02885	COG0459	protein refolding
IOD66_RS02890	COG1454	alcohol dehydrogenase
IOD66_RS02890	COG1012	belongs to the aldehyde dehydrogenase family
IOD66_RS02895	COG0181	hydroxymethylbilane synthase activity
IOD66_RS02905	COG2959	enzyme of heme biosynthesis
IOD66_RS02910	COG3071	HemY protein
IOD66_RS02915	COG2354	Protein conserved in bacteria
IOD66_RS02920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IOD66_RS02930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD66_RS02935	COG2095	MarC family integral membrane protein
IOD66_RS02945	COG0489	protein tyrosine kinase activity
IOD66_RS02965	COG2017	converts alpha-aldose to the beta-anomer
IOD66_RS02970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IOD66_RS02975	COG1085	galactose-1-phosphate uridylyltransferase
IOD66_RS02980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD66_RS02985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD66_RS02990	COG1408	metallophosphoesterase
IOD66_RS03000	COG2963	transposase activity
IOD66_RS03005	COG0753	catalase activity
IOD66_RS03010	COG0326	Molecular chaperone. Has ATPase activity
IOD66_RS03025	COG0254	rRNA binding
IOD66_RS03045	COG0583	DNA-binding transcription factor activity
IOD66_RS03050	COG0708	Exodeoxyribonuclease III
IOD66_RS03060	COG0037	tRNA processing
IOD66_RS03065	COG3092	negative regulation of chromosome organization
IOD66_RS03080	COG1607	acyl-coa hydrolase
IOD66_RS03085	COG2350	Protein conserved in bacteria
IOD66_RS03095	COG3112	Uncharacterised protein family (UPF0231)
IOD66_RS03100	COG0786	glutamate:sodium symporter activity
IOD66_RS03105	COG0569	domain protein
IOD66_RS03105	COG2985	domain, Protein
IOD66_RS03110	COG3078	GTPase activator activity
IOD66_RS03120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD66_RS03125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IOD66_RS03135	COG3210	domain, Protein
IOD66_RS03160	COG0138	bifunctional purine biosynthesis protein purh
IOD66_RS03165	COG1444	tRNA N-acetyltransferase activity
IOD66_RS03200	COG3620	sequence-specific DNA binding
IOD66_RS03205	COG2856	Zn peptidase
IOD66_RS03215	COG2801	Transposase and inactivated derivatives
IOD66_RS03235	COG2027	D-alanyl-D-alanine carboxypeptidase
IOD66_RS03240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD66_RS03250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD66_RS03255	COG0156	8-amino-7-oxononanoate synthase activity
IOD66_RS03260	COG2830	Protein of unknown function (DUF452)
IOD66_RS03265	COG2226	methyltransferase
IOD66_RS03270	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD66_RS03275	COG2840	Smr protein MutS2
IOD66_RS03280	COG0697	spore germination
IOD66_RS03285	COG5002	protein histidine kinase activity
IOD66_RS03285	COG0784	Response regulator, receiver
IOD66_RS03285	COG2198	Histidine kinase
IOD66_RS03290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD66_RS03300	COG1959	2 iron, 2 sulfur cluster binding
IOD66_RS03305	COG1104	cysteine desulfurase activity
IOD66_RS03310	COG0822	iron-sulfur transferase activity
IOD66_RS03320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IOD66_RS03335	COG0443	Heat shock 70 kDa protein
IOD66_RS03340	COG0633	Ferredoxin
IOD66_RS03345	COG2975	iron-sulfur cluster assembly
IOD66_RS03375	COG0617	tRNA 3'-terminal CCA addition
IOD66_RS03380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD66_RS03385	COG0215	cysteine-tRNA ligase activity
IOD66_RS03390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD66_RS03410	COG0583	DNA-binding transcription factor activity
IOD66_RS03420	COG0110	maltose O-acetyltransferase activity
IOD66_RS03430	COG3642	lipopolysaccharide core region biosynthetic process
IOD66_RS03435	COG0302	gtp cyclohydrolase
IOD66_RS03445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD66_RS03450	COG1560	Kdo2-lipid A biosynthetic process
IOD66_RS03455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD66_RS03465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOD66_RS03480	COG3058	Necessary for formate dehydrogenase activity
IOD66_RS03485	COG2864	formate dehydrogenase
IOD66_RS03490	COG0437	4 iron, 4 sulfur cluster binding
IOD66_RS03500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOD66_RS03515	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD66_RS03515	COG1024	Enoyl-CoA hydratase
IOD66_RS03525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOD66_RS03530	COG0730	response to heat
IOD66_RS03535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IOD66_RS03540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOD66_RS03550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOD66_RS03555	COG4969	Belongs to the N-Me-Phe pilin family
IOD66_RS03560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOD66_RS03565	COG1459	type II secretion system
IOD66_RS03575	COG0237	dephospho-CoA kinase activity
IOD66_RS03580	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IOD66_RS03585	COG1466	dna polymerase III delta subunit
IOD66_RS03590	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IOD66_RS03595	COG0495	leucyl-tRNA aminoacylation
IOD66_RS03600	COG3340	Belongs to the peptidase S51 family
IOD66_RS03605	COG3069	C4-dicarboxylate transmembrane transporter activity
IOD66_RS03610	COG1473	amidohydrolase
IOD66_RS03615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IOD66_RS03620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IOD66_RS03625	COG3106	COG3106 Predicted ATPase
IOD66_RS03630	COG3025	triphosphatase activity
IOD66_RS03640	COG3140	Belongs to the UPF0181 family
IOD66_RS03645	COG0564	pseudouridine synthase activity
IOD66_RS03650	COG3098	single-species biofilm formation
IOD66_RS03655	COG3177	Filamentation induced by cAMP protein fic
IOD66_RS03660	COG0134	indole-3-glycerol-phosphate synthase activity
IOD66_RS03660	COG0135	phosphoribosylanthranilate isomerase activity
IOD66_RS03665	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IOD66_RS03665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD66_RS03670	COG1760	l-serine dehydratase
IOD66_RS03675	COG0814	amino acid
IOD66_RS03680	COG0747	negative chemotaxis
IOD66_RS03690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD66_RS03700	COG4608	Belongs to the ABC transporter superfamily
IOD66_RS03705	COG0444	Belongs to the ABC transporter superfamily
IOD66_RS03715	COG4166	transmembrane transport
IOD66_RS03720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD66_RS03725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOD66_RS03730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOD66_RS03735	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IOD66_RS03735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IOD66_RS03740	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IOD66_RS03745	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOD66_RS03750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IOD66_RS03760	COG0842	Transport permease protein
IOD66_RS03765	COG0842	Transport permease protein
IOD66_RS03765	COG1129	ABC transporter
IOD66_RS03770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_RS03775	COG1309	transcriptional regulator
IOD66_RS03780	COG0717	Belongs to the dCTP deaminase family
IOD66_RS03785	COG0572	uridine kinase
IOD66_RS03795	COG0588	phosphoglycerate mutase activity
IOD66_RS03800	COG4942	peptidase
IOD66_RS03805	COG2861	carbohydrate metabolic process
IOD66_RS03810	COG0729	surface antigen
IOD66_RS03815	COG2911	Protein conserved in bacteria
IOD66_RS03820	COG4988	ABC transporter
IOD66_RS03825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IOD66_RS03830	COG2915	High frequency lysogenization protein hflD homolog
IOD66_RS03835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD66_RS03840	COG1349	DNA-binding transcription factor activity
IOD66_RS03845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOD66_RS03850	COG0187	DNA topoisomerase II activity
IOD66_RS03855	COG0586	Pfam SNARE associated Golgi protein
IOD66_RS03860	COG1609	Transcriptional regulator
IOD66_RS03865	COG2351	hydroxyisourate hydrolase activity
IOD66_RS03885	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IOD66_RS03895	COG0500	methyltransferase
IOD66_RS03910	COG1944	ATP diphosphatase activity
IOD66_RS03915	COG1530	ribonuclease E activity
IOD66_RS03920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IOD66_RS03930	COG0142	geranyltranstransferase activity
IOD66_RS03935	COG1722	exodeoxyribonuclease VII activity
IOD66_RS03940	COG3217	Mosc domain protein beta barrel domain protein
IOD66_RS03940	COG0633	Ferredoxin
IOD66_RS03945	COG1368	sulfuric ester hydrolase activity
IOD66_RS03955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IOD66_RS03960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IOD66_RS03965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IOD66_RS03970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IOD66_RS03980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IOD66_RS03985	COG3283	Transcriptional regulator of aromatic amino acids metabolism
IOD66_RS03990	COG4166	transmembrane transport
IOD66_RS03995	COG4168	peptide transport system, permease
IOD66_RS04000	COG4171	peptide transport system, permease
IOD66_RS04005	COG4172	Belongs to the ABC transporter superfamily
IOD66_RS04010	COG2315	Protein conserved in bacteria
IOD66_RS04015	COG2814	Major facilitator Superfamily
IOD66_RS04030	COG2070	2-Nitropropane dioxygenase
IOD66_RS04070	COG0629	single-stranded DNA binding
IOD66_RS04075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD66_RS04085	COG1199	ATP-dependent helicase activity
IOD66_RS04095	COG1346	cytolysis
IOD66_RS04100	COG1132	(ABC) transporter
IOD66_RS04105	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IOD66_RS04115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOD66_RS04120	COG0167	dihydroorotate dehydrogenase activity
IOD66_RS04125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IOD66_RS04130	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD66_RS04135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD66_RS04165	COG0737	Belongs to the 5'-nucleotidase family
IOD66_RS04170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IOD66_RS04175	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IOD66_RS04180	COG2333	competence protein COMEC
IOD66_RS04180	COG0658	competence protein
IOD66_RS04185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IOD66_RS04200	COG2226	methyltransferase
IOD66_RS04205	COG3036	rescue of stalled ribosome
IOD66_RS04215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOD66_RS04220	COG1346	cytolysis
IOD66_RS04225	COG1380	Effector of murein hydrolase LrgA
IOD66_RS04230	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IOD66_RS04245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IOD66_RS04250	COG2226	methyltransferase
IOD66_RS04255	COG0596	Alpha beta hydrolase
IOD66_RS04260	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IOD66_RS04265	COG0318	PFAM AMP-dependent synthetase and ligase
IOD66_RS04270	COG3264	Mechanosensitive ion channel
IOD66_RS04270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IOD66_RS04275	COG3264	Mechanosensitive ion channel
IOD66_RS04275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IOD66_RS04280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IOD66_RS04285	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IOD66_RS04300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD66_RS04310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD66_RS04320	COG0539	negative regulation of cytoplasmic translation
IOD66_RS04325	COG0776	regulation of translation
IOD66_RS04330	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IOD66_RS04335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IOD66_RS04340	COG0284	orotidine-5'-phosphate decarboxylase activity
IOD66_RS04345	COG0023	Translation Initiation Factor
IOD66_RS04350	COG3787	Belongs to the UPF0306 family
IOD66_RS04355	COG1811	Na channel or pump
IOD66_RS04365	COG3094	Invasion gene expression up-regulator, SirB
IOD66_RS04370	COG3028	Belongs to the UPF0307 family
IOD66_RS04375	COG0312	modulator of DNA gyrase
IOD66_RS04380	COG0440	acetolactate synthase activity
IOD66_RS04385	COG0028	Belongs to the TPP enzyme family
IOD66_RS04390	COG0288	reversible hydration of carbon dioxide
IOD66_RS04395	COG1278	Cold shock
IOD66_RS04405	COG0343	queuine tRNA-ribosyltransferase activity
IOD66_RS04410	COG3945	hemerythrin HHE cation binding domain
IOD66_RS04420	COG4991	sh3 domain protein
IOD66_RS04425	COG0306	phosphate transporter
IOD66_RS04430	COG1392	Phosphate transport regulator
IOD66_RS04435	COG4604	ABC transporter, ATP-binding protein
IOD66_RS04440	COG4605	iron ion homeostasis
IOD66_RS04445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD66_RS04450	COG4607	ABC-type enterochelin transport system periplasmic component
IOD66_RS04455	COG0305	Participates in initiation and elongation during chromosome replication
IOD66_RS04460	COG3100	YcgL domain-containing protein
IOD66_RS04465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IOD66_RS04470	COG0527	aspartate kinase activity
IOD66_RS04475	COG2926	Belongs to the UPF0265 family
IOD66_RS04480	COG0248	Ppx GppA phosphatase
IOD66_RS04485	COG2731	YhcH YjgK YiaL family protein
IOD66_RS04490	COG1737	Transcriptional regulator
IOD66_RS04505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD66_RS04510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IOD66_RS04525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOD66_RS04530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IOD66_RS04530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD66_RS04545	COG1444	tRNA N-acetyltransferase activity
IOD66_RS04550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IOD66_RS04555	COG0314	molybdopterin synthase activity
IOD66_RS04560	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IOD66_RS04565	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD66_RS04570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOD66_RS04575	COG3005	denitrification pathway
IOD66_RS04580	COG0243	molybdopterin cofactor binding
IOD66_RS04585	COG0277	FAD linked oxidase domain protein
IOD66_RS04590	COG2363	Small membrane protein
IOD66_RS04595	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IOD66_RS04600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IOD66_RS04605	COG0626	cystathionine gamma-synthase activity
IOD66_RS04610	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IOD66_RS04615	COG0741	lytic transglycosylase activity
IOD66_RS04620	COG2814	Major facilitator Superfamily
IOD66_RS04630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD66_RS04635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IOD66_RS04645	COG1509	lysine 2,3-aminomutase activity
IOD66_RS04650	COG0017	Asparaginyl-tRNA synthetase
IOD66_RS04655	COG0038	chloride channel
IOD66_RS04660	COG2925	Exonuclease
IOD66_RS04670	COG0613	PHP domain protein
IOD66_RS04680	COG2837	iron assimilation
IOD66_RS04685	COG2822	iron ion transport
IOD66_RS04690	COG0556	nucleotide-excision repair
IOD66_RS04700	COG1487	ribonuclease activity
IOD66_RS04710	COG0006	proline dipeptidase activity
IOD66_RS04715	COG1448	Aminotransferase
IOD66_RS04720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOD66_RS04730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IOD66_RS04735	COG0625	glutathione transferase activity
IOD66_RS04740	COG2969	positive regulation of protein catabolic process
IOD66_RS04750	COG0589	response to stress
IOD66_RS04760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IOD66_RS04770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD66_RS04790	COG0737	Belongs to the 5'-nucleotidase family
IOD66_RS04800	COG0857	belongs to the CobB CobQ family
IOD66_RS04800	COG0280	phosphate acetyltransferase
IOD66_RS04810	COG2951	lytic endotransglycosylase activity
IOD66_RS04815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOD66_RS04820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IOD66_RS04825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IOD66_RS04830	COG0195	Participates in both transcription termination and antitermination
IOD66_RS04835	COG0779	Required for maturation of 30S ribosomal subunits
IOD66_RS04845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD66_RS04855	COG0732	type I restriction modification DNA specificity domain
IOD66_RS04865	COG0285	dihydrofolate synthase activity
IOD66_RS04875	COG3956	TIGRFAM MazG family protein
IOD66_RS04880	COG0745	RESPONSE REGULATOR receiver
IOD66_RS04890	COG1136	(ABC) transporter
IOD66_RS04890	COG0577	efflux transmembrane transporter activity
IOD66_RS04895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOD66_RS04900	COG1494	fructose-1,6-bisphosphatase
IOD66_RS04905	COG3074	FtsZ-dependent cytokinesis
IOD66_RS04910	COG1435	thymidine kinase activity
IOD66_RS04915	COG1214	PFAM Peptidase M22, glycoprotease
IOD66_RS04920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD66_RS04925	COG2321	neutral zinc metallopeptidase
IOD66_RS04930	COG1674	ftsk spoiiie
IOD66_RS04935	COG1522	sequence-specific DNA binding
IOD66_RS04940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IOD66_RS04945	COG1940	carbohydrate kinase activity
IOD66_RS04945	COG1846	Transcriptional regulator
IOD66_RS04950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD66_RS04960	COG0791	NLP P60 protein
IOD66_RS04965	COG0776	regulation of translation
IOD66_RS04970	COG0072	phenylalanine-tRNA ligase activity
IOD66_RS04975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IOD66_RS04980	COG0778	Nitroreductase
IOD66_RS04985	COG1823	symporter activity
IOD66_RS05005	COG3022	response to hydroperoxide
IOD66_RS05015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IOD66_RS05020	COG3105	Protein conserved in bacteria
IOD66_RS05030	COG0814	amino acid
IOD66_RS05040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD66_RS05045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IOD66_RS05050	COG0517	IMP dehydrogenase activity
IOD66_RS05050	COG0516	GMP reductase activity
IOD66_RS05065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD66_RS05070	COG3955	Domain of unknown function (DUF1919)
IOD66_RS05080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOD66_RS05085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD66_RS05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_RS05095	COG1309	transcriptional regulator
IOD66_RS05100	COG3082	Protein of unknown function (DUF1414)
IOD66_RS05105	COG3083	sulfuric ester hydrolase activity
IOD66_RS05115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IOD66_RS05120	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IOD66_RS05130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD66_RS05135	COG1185	polyribonucleotide nucleotidyltransferase activity
IOD66_RS05140	COG4785	May be involved in cell division
IOD66_RS05145	COG0513	Belongs to the DEAD box helicase family
IOD66_RS05150	COG0590	tRNA wobble adenosine to inosine editing
IOD66_RS05155	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IOD66_RS05160	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IOD66_RS05165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD66_RS05170	COG0233	cytoplasmic translational termination
IOD66_RS05175	COG0528	UMP kinase activity
IOD66_RS05180	COG2194	sulfuric ester hydrolase activity
IOD66_RS05185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IOD66_RS05210	COG1840	ABC-type Fe3 transport system, periplasmic component
IOD66_RS05215	COG0433	COG0433 Predicted ATPase
IOD66_RS05250	COG1381	Involved in DNA repair and RecF pathway recombination
IOD66_RS05255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOD66_RS05260	COG0571	ribonuclease III activity
IOD66_RS05265	COG0681	Belongs to the peptidase S26 family
IOD66_RS05270	COG0481	GTPase activity
IOD66_RS05285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD66_RS05290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOD66_RS05295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOD66_RS05305	COG2104	thiamine diphosphate biosynthetic process
IOD66_RS05315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD66_RS05325	COG1115	amino acid carrier protein
IOD66_RS05330	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD66_RS05335	COG3683	transport system, periplasmic component
IOD66_RS05350	COG0280	phosphate acetyltransferase
IOD66_RS05350	COG0281	malic enzyme
IOD66_RS05355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD66_RS05360	COG0189	ligase activity
IOD66_RS05370	COG0640	Transcriptional regulator
IOD66_RS05395	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD66_RS05400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD66_RS05410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IOD66_RS05425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD66_RS05425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD66_RS05440	COG0159	tryptophan synthase activity
IOD66_RS05445	COG0133	tryptophan synthase activity
IOD66_RS05450	COG4221	oxidoreductase activity
IOD66_RS05460	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IOD66_RS05465	COG0393	Putative heavy-metal-binding
IOD66_RS05470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IOD66_RS05480	COG3850	Histidine kinase
IOD66_RS05485	COG0561	phosphatase activity
IOD66_RS05495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOD66_RS05500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_RS05505	COG0739	heme binding
IOD66_RS05510	COG1121	(ABC) transporter
IOD66_RS05515	COG0567	Dehydrogenase, E1 component
IOD66_RS05520	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD66_RS05525	COG2990	Protein conserved in bacteria
IOD66_RS05530	COG0045	succinate-CoA ligase (ADP-forming) activity
IOD66_RS05535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IOD66_RS05540	COG1879	ABC-type sugar transport system periplasmic component
IOD66_RS05545	COG1757	Na H antiporter
IOD66_RS05550	COG2916	Histone family protein nucleoid-structuring protein H-NS
IOD66_RS05555	COG1620	l-lactate permease
IOD66_RS05560	COG0247	lactate metabolic process
IOD66_RS05565	COG1139	Iron-sulfur cluster binding protein
IOD66_RS05570	COG1556	Lactate utilization protein
IOD66_RS05580	COG2949	membrane
IOD66_RS05585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD66_RS05590	COG0121	glutamine amidotransferase
IOD66_RS05595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD66_RS05600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOD66_RS05605	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IOD66_RS05610	COG1792	Involved in formation and maintenance of cell shape
IOD66_RS05620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD66_RS05635	COG5645	(Lipo)protein
IOD66_RS05645	COG1496	oxidoreductase activity
IOD66_RS05650	COG0251	oxidation-reduction process
IOD66_RS05655	COG3081	Nucleoid-associated protein
IOD66_RS05660	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD66_RS05665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD66_RS05675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IOD66_RS05680	COG1286	toxin biosynthetic process
IOD66_RS05685	COG0328	RNA-DNA hybrid ribonuclease activity
IOD66_RS05695	COG0859	PFAM glycosyl transferase family 9
IOD66_RS05700	COG1686	Belongs to the peptidase S11 family
IOD66_RS05705	COG0463	Glycosyl transferase, family 2
IOD66_RS05710	COG1534	Rna-binding protein
IOD66_RS05715	COG0671	phosphoesterase, PA-phosphatase related
IOD66_RS05725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD66_RS05730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOD66_RS05735	COG0575	Belongs to the CDS family
IOD66_RS05740	COG0750	zinc metalloprotease
IOD66_RS05755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_RS05760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD66_RS05765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_RS05770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IOD66_RS05775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD66_RS05780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IOD66_RS05785	COG1160	GTP binding
IOD66_RS05790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IOD66_RS05790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IOD66_RS05795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IOD66_RS05800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD66_RS05805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD66_RS05810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IOD66_RS05815	COG0318	PFAM AMP-dependent synthetase and ligase
IOD66_RS05825	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IOD66_RS05830	COG1595	DNA-templated transcription, initiation
IOD66_RS05840	COG0561	phosphatase activity
IOD66_RS05845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_RS05850	COG0385	Bile acid
IOD66_RS05855	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IOD66_RS05865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOD66_RS05865	COG0517	IMP dehydrogenase activity
IOD66_RS05880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD66_RS05880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD66_RS05895	COG0247	lactate metabolic process
IOD66_RS05900	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
IOD66_RS05905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD66_RS05910	COG0584	glycerophosphoryl diester phosphodiesterase
IOD66_RS05915	COG2271	Major facilitator Superfamily
IOD66_RS05920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD66_RS05925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD66_RS05930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD66_RS05940	COG4535	Mg2 and Co2 transporter CorC
IOD66_RS05945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IOD66_RS05950	COG1074	ATP-dependent DNA helicase activity
IOD66_RS05955	COG0534	Mate efflux family protein
IOD66_RS05960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IOD66_RS05965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IOD66_RS05970	COG2707	UPF0756 membrane protein
IOD66_RS05975	COG1643	Atp-dependent helicase
IOD66_RS05985	COG2990	Protein conserved in bacteria
IOD66_RS05990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IOD66_RS05995	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IOD66_RS06000	COG2932	Transcriptional regulator
IOD66_RS06005	COG0791	NLP P60 protein
IOD66_RS06010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IOD66_RS06015	COG3381	protein complex oligomerization
IOD66_RS06025	COG2814	Major facilitator Superfamily
IOD66_RS06030	COG1187	pseudouridine synthase activity
IOD66_RS06045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD66_RS06045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD66_RS06050	COG0105	UTP biosynthetic process
IOD66_RS06055	COG0058	SHG alpha-glucan phosphorylase activity
IOD66_RS06060	COG0297	glycogen (starch) synthase activity
IOD66_RS06065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IOD66_RS06070	COG1523	belongs to the glycosyl hydrolase 13 family
IOD66_RS06075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IOD66_RS06080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_RS06080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_RS06085	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD66_RS06090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD66_RS06090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD66_RS06090	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOD66_RS06095	COG1704	LemA family
IOD66_RS06105	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IOD66_RS06110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IOD66_RS06120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IOD66_RS06125	COG1137	ATPase activity
IOD66_RS06130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_RS06135	COG1660	Displays ATPase and GTPase activities
IOD66_RS06140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD66_RS06160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD66_RS06185	COG1702	phosphate starvation-inducible protein PhoH
IOD66_RS06200	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IOD66_RS06205	COG0626	cystathionine gamma-synthase activity
IOD66_RS06210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD66_RS06215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IOD66_RS06220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IOD66_RS06225	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD66_RS06230	COG0564	pseudouridine synthase activity
IOD66_RS06235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD66_RS06240	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IOD66_RS06245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD66_RS06255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IOD66_RS06260	COG0303	'Molybdopterin
IOD66_RS06270	COG0488	(ABC) transporter
IOD66_RS06280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD66_RS06285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IOD66_RS06300	COG0823	Involved in the tonB-independent uptake of proteins
IOD66_RS06305	COG3064	Membrane
IOD66_RS06305	COG3064	Membrane
IOD66_RS06310	COG0848	biopolymer transport protein
IOD66_RS06315	COG0811	peptide transport
IOD66_RS06320	COG0824	Thioesterase
IOD66_RS06335	COG1294	oxidase, subunit
IOD66_RS06340	COG1271	oxidase subunit
IOD66_RS06350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOD66_RS06355	COG0488	(ABC) transporter
IOD66_RS06385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD66_RS06390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD66_RS06395	COG2255	four-way junction helicase activity
IOD66_RS06400	COG0632	four-way junction helicase activity
IOD66_RS06405	COG1177	transmembrane transport
IOD66_RS06410	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD66_RS06415	COG3842	ATPase activity
IOD66_RS06420	COG0210	DNA helicase
IOD66_RS06425	COG0084	hydrolase, TatD family'
IOD66_RS06430	COG0322	excinuclease ABC activity
IOD66_RS06440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOD66_RS06445	COG0670	Belongs to the BI1 family
IOD66_RS06450	COG2920	part of a sulfur-relay system
IOD66_RS06460	COG1121	(ABC) transporter
IOD66_RS06465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD66_RS06470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD66_RS06475	COG0251	oxidation-reduction process
IOD66_RS06485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD66_RS06490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IOD66_RS06495	COG1131	(ABC) transporter
IOD66_RS06500	COG0842	Transport permease protein
IOD66_RS06505	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD66_RS06510	COG4149	molybdate abc transporter
IOD66_RS06515	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IOD66_RS06520	COG2867	negative regulation of translational initiation
IOD66_RS06525	COG2914	Belongs to the UPF0125 (RnfH) family
IOD66_RS06530	COG1538	Outer membrane efflux protein
IOD66_RS06535	COG0194	GDP metabolic process
IOD66_RS06540	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IOD66_RS06545	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOD66_RS06570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD66_RS06575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD66_RS06580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOD66_RS06585	COG0527	aspartate kinase activity
IOD66_RS06585	COG0460	homoserine dehydrogenase
IOD66_RS06590	COG0083	homoserine kinase activity
IOD66_RS06595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD66_RS06600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOD66_RS06615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD66_RS06620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD66_RS06625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IOD66_RS06630	COG0494	nUDIX hydrolase
IOD66_RS06640	COG0653	protein targeting
IOD66_RS06665	COG0271	Belongs to the BolA IbaG family
IOD66_RS06675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOD66_RS06680	COG1678	Uncharacterized ACR, COG1678
IOD66_RS06685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOD66_RS06690	COG0588	phosphoglycerate mutase activity
IOD66_RS06695	COG0564	pseudouridine synthase activity
IOD66_RS06700	COG1253	flavin adenine dinucleotide binding
IOD66_RS06715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IOD66_RS06720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IOD66_RS06725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IOD66_RS06745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IOD66_RS06780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOD66_RS06785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD66_RS06795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IOD66_RS06805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD66_RS06810	COG1280	lysine exporter protein (LysE YggA)
IOD66_RS06815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOD66_RS06820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IOD66_RS06825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IOD66_RS06830	COG4796	Type ii and iii secretion system protein
IOD66_RS06850	COG4972	Pilus assembly protein
IOD66_RS06855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IOD66_RS06860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD66_RS06865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IOD66_RS06870	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IOD66_RS06875	COG0733	neurotransmitter:sodium symporter activity
IOD66_RS06880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IOD66_RS06885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD66_RS06890	COG2062	phosphohistidine phosphatase, SixA
IOD66_RS06895	COG0469	pyruvate kinase activity
IOD66_RS06900	COG0859	PFAM glycosyl transferase family 9
IOD66_RS06905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD66_RS06910	COG1605	Chorismate mutase
IOD66_RS06910	COG0287	Prephenate dehydrogenase
IOD66_RS06920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD66_RS06925	COG0346	lactoylglutathione lyase activity
IOD66_RS06935	COG2911	Protein conserved in bacteria
IOD66_RS06945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOD66_RS06950	COG0617	tRNA 3'-terminal CCA addition
IOD66_RS06955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOD66_RS06960	COG4143	(ABC) transporter
IOD66_RS06965	COG0402	S-adenosylhomocysteine deaminase activity
IOD66_RS06970	COG1560	Kdo2-lipid A biosynthetic process
IOD66_RS06985	COG4658	electron transport chain
IOD66_RS06995	COG4656	Part of a membrane complex involved in electron transport
IOD66_RS07000	COG2878	Part of a membrane complex involved in electron transport
IOD66_RS07005	COG4657	Part of a membrane complex involved in electron transport
IOD66_RS07020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD66_RS07025	COG2974	May be involved in recombination
IOD66_RS07030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOD66_RS07035	COG2814	Major facilitator Superfamily
IOD66_RS07040	COG0482	sulfurtransferase activity
IOD66_RS07045	COG2991	Protein conserved in bacteria
IOD66_RS07050	COG1477	protein flavinylation
IOD66_RS07055	COG2871	sodium ion transport
IOD66_RS07060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_RS07065	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_RS07070	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_RS07075	COG1805	sodium ion transport
IOD66_RS07080	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_RS07085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IOD66_RS07085	COG0316	Belongs to the HesB IscA family
IOD66_RS07090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD66_RS07100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD66_RS07105	COG1611	Belongs to the LOG family
IOD66_RS07110	COG3593	DNA synthesis involved in DNA repair
IOD66_RS07115	COG1254	Belongs to the acylphosphatase family
IOD66_RS07120	COG1929	Belongs to the glycerate kinase type-1 family
IOD66_RS07125	COG2610	gluconate transmembrane transporter activity
IOD66_RS07130	COG3835	regulator
IOD66_RS07135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IOD66_RS07140	COG0066	3-isopropylmalate dehydratase activity
IOD66_RS07145	COG5413	integral membrane protein
IOD66_RS07150	COG0504	CTP synthase activity
IOD66_RS07155	COG0252	asparaginase activity
IOD66_RS07165	COG0583	DNA-binding transcription factor activity
IOD66_RS07170	COG1011	Hydrolase
IOD66_RS07175	COG0583	DNA-binding transcription factor activity
IOD66_RS07180	COG1162	GTPase activity
IOD66_RS07185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOD66_RS07190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD66_RS07195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD66_RS07200	COG0537	adenosine 5'-monophosphoramidase activity
IOD66_RS07215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD66_RS07220	COG3108	Peptidase M15
IOD66_RS07225	COG2989	Protein conserved in bacteria
IOD66_RS07230	COG0793	Belongs to the peptidase S41A family
IOD66_RS07235	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IOD66_RS07240	COG1278	Cold shock
IOD66_RS07245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOD66_RS07265	COG3068	Protein conserved in bacteria
IOD66_RS07270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IOD66_RS07280	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IOD66_RS07290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD66_RS07295	COG1414	Transcriptional regulator
IOD66_RS07300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD66_RS07325	COG3301	Polysulphide reductase, NrfD
IOD66_RS07330	COG0437	4 iron, 4 sulfur cluster binding
IOD66_RS07335	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IOD66_RS07350	COG3978	acetolactate synthase activity
IOD66_RS07355	COG0129	dihydroxy-acid dehydratase activity
IOD66_RS07375	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IOD66_RS07385	COG0006	proline dipeptidase activity
IOD66_RS07390	COG3030	protein affecting phage T7 exclusion by the F plasmid
IOD66_RS07410	COG3753	Protein conserved in bacteria
IOD66_RS07415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IOD66_RS07420	COG0492	ferredoxin-NADP+ reductase activity
IOD66_RS07425	COG2376	Dihydroxyacetone kinase
IOD66_RS07430	COG1461	Dihydroxyacetone kinase
IOD66_RS07435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD66_RS07435	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IOD66_RS07435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_RS07440	COG3118	belongs to the thioredoxin family
IOD66_RS07445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD66_RS07450	COG0811	peptide transport
IOD66_RS07455	COG0848	biopolymer transport protein
IOD66_RS07460	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IOD66_RS07465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IOD66_RS07470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOD66_RS07475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IOD66_RS07480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD66_RS07485	COG0251	oxidation-reduction process
IOD66_RS07500	COG4608	Belongs to the ABC transporter superfamily
IOD66_RS07505	COG0444	Belongs to the ABC transporter superfamily
IOD66_RS07515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD66_RS07520	COG0601	transmembrane transport
IOD66_RS07525	COG0747	negative chemotaxis
IOD66_RS07530	COG0747	negative chemotaxis
IOD66_RS07570	COG3630	sodium ion export across plasma membrane
IOD66_RS07580	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IOD66_RS07585	COG2824	Alkylphosphonate utilization operon protein PhnA
IOD66_RS07590	COG1858	cytochrome C peroxidase
IOD66_RS07595	COG1872	DUF167
IOD66_RS07600	COG0762	integral membrane protein
IOD66_RS07605	COG3171	Protein conserved in bacteria
IOD66_RS07610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOD66_RS07615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD66_RS07620	COG0416	fatty acid biosynthetic process
IOD66_RS07625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IOD66_RS07630	COG1399	metal-binding, possibly nucleic acid-binding protein
IOD66_RS07635	COG4137	Cytochrome C assembly protein
IOD66_RS07640	COG4536	flavin adenine dinucleotide binding
IOD66_RS07645	COG0733	neurotransmitter:sodium symporter activity
IOD66_RS07655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD66_RS07655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_RS07660	COG3715	PTS system
IOD66_RS07665	COG3716	PTS system mannose fructose sorbose family IID component
IOD66_RS07690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD66_RS07695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IOD66_RS07700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD66_RS07720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD66_RS07730	COG1720	tRNA m6t6A37 methyltransferase activity
IOD66_RS07735	COG4804	nuclease activity
IOD66_RS07740	COG1575	Belongs to the MenA family. Type 1 subfamily
IOD66_RS07745	COG0316	Belongs to the HesB IscA family
IOD66_RS07765	COG1442	glycosyl transferase family 8
IOD66_RS07765	COG1216	Glycosyl transferase, family 2
IOD66_RS07790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOD66_RS07795	COG1088	dTDP-glucose 4,6-dehydratase activity
IOD66_RS07800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IOD66_RS07810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD66_RS07815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOD66_RS07825	COG0557	exoribonuclease II activity
IOD66_RS07830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD66_RS07835	COG1309	transcriptional regulator
IOD66_RS07840	COG0583	DNA-binding transcription factor activity
IOD66_RS07845	COG0678	peroxiredoxin activity
IOD66_RS07845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD66_RS07855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IOD66_RS07860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD66_RS07875	COG1840	ABC-type Fe3 transport system, periplasmic component
IOD66_RS07905	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IOD66_RS07910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD66_RS07915	COG1755	Isoprenylcysteine carboxyl methyltransferase
IOD66_RS07925	COG1530	ribonuclease E activity
IOD66_RS07940	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD66_RS07945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD66_RS07955	COG0243	molybdopterin cofactor binding
IOD66_RS07960	COG0437	4 iron, 4 sulfur cluster binding
IOD66_RS07965	COG0348	domain, Protein
IOD66_RS07970	COG3043	anaerobic respiration
IOD66_RS07975	COG3005	denitrification pathway
IOD66_RS07985	COG2050	protein possibly involved in aromatic compounds catabolism
IOD66_RS07990	COG0247	lactate metabolic process
IOD66_RS07990	COG0277	FAD linked oxidase domain protein
IOD66_RS07995	COG2885	chlorophyll binding
IOD66_RS07995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOD66_RS08000	COG1879	ABC-type sugar transport system periplasmic component
IOD66_RS08005	COG1129	ABC transporter
IOD66_RS08010	COG4211	Belongs to the binding-protein-dependent transport system permease family
IOD66_RS08030	COG0579	oxidoreductase
IOD66_RS08035	COG1022	Amp-dependent synthetase and ligase
IOD66_RS08040	COG4989	oxidoreductase activity
IOD66_RS08045	COG3691	Protein conserved in bacteria
IOD66_RS08050	COG0814	amino acid
IOD66_RS08060	COG2918	glutathione biosynthetic process
IOD66_RS08060	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD66_RS08065	COG0688	phosphatidylethanolamine metabolic process
IOD66_RS08070	COG1555	photosystem II stabilization
IOD66_RS08075	COG3266	domain, Protein
IOD66_RS08075	COG3061	Opacity-associated protein A
IOD66_RS08085	COG0859	PFAM glycosyl transferase family 9
IOD66_RS08090	COG0859	PFAM glycosyl transferase family 9
IOD66_RS08095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IOD66_RS08100	COG0049	tRNA binding
IOD66_RS08105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD66_RS08110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD66_RS08125	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IOD66_RS08135	COG0825	malonyl-CoA metabolic process
IOD66_RS08145	COG0204	Acyl-transferase
IOD66_RS08150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IOD66_RS08155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IOD66_RS08160	COG2848	UPF0210 protein
IOD66_RS08175	COG0783	Belongs to the Dps family
IOD66_RS08190	COG1289	transmembrane transporter activity
IOD66_RS08195	COG1803	Methylglyoxal synthase
IOD66_RS08200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD66_RS08210	COG0525	valine-tRNA ligase activity
IOD66_RS08225	COG2153	protein acetylation
IOD66_RS08230	COG2927	DNA polymerase III (CHI subunit)
IOD66_RS08235	COG1652	LysM domain
IOD66_RS08240	COG0544	peptidyl-prolyl cis-trans isomerase activity
IOD66_RS08245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD66_RS08250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IOD66_RS08255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOD66_RS08260	COG1045	serine acetyltransferase
IOD66_RS08265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD66_RS08290	COG1072	(Pantothenic acid kinase))
IOD66_RS08295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD66_RS08310	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD66_RS08320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IOD66_RS08325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IOD66_RS08330	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IOD66_RS08345	COG0625	glutathione transferase activity
IOD66_RS08350	COG0019	diaminopimelate decarboxylase activity
IOD66_RS08360	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IOD66_RS08365	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IOD66_RS08370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD66_RS08375	COG1053	succinate dehydrogenase
IOD66_RS08380	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IOD66_RS08385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IOD66_RS08390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD66_RS08395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD66_RS08405	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IOD66_RS08410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IOD66_RS08415	COG2264	protein methyltransferase activity
IOD66_RS08435	COG0037	tRNA processing
IOD66_RS08445	COG4974	Belongs to the 'phage' integrase family
IOD66_RS08490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOD66_RS08500	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IOD66_RS08505	COG1522	sequence-specific DNA binding
IOD66_RS08510	COG2502	aspartate--ammonia ligase
IOD66_RS08530	COG3311	Transcriptional regulator
IOD66_RS08560	COG3210	domain, Protein
IOD66_RS08560	COG3210	domain, Protein
IOD66_RS08565	COG2831	hemolysin activation secretion protein
IOD66_RS08595	COG0640	Transcriptional regulator
IOD66_RS08610	COG0786	glutamate:sodium symporter activity
IOD66_RS08630	COG0582	viral genome integration into host DNA
IOD66_RS08645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD66_RS08655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IOD66_RS08660	COG1595	DNA-templated transcription, initiation
IOD66_RS08670	COG0442	prolyl-tRNA aminoacylation
IOD66_RS08685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOD66_RS08695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD66_RS08700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IOD66_RS08705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD66_RS08710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOD66_RS08715	COG0254	rRNA binding
IOD66_RS08720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD66_RS08725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD66_RS08745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOD66_RS08750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IOD66_RS08755	COG0470	DNA polymerase III
IOD66_RS08765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_RS08780	COG0084	hydrolase, TatD family'
IOD66_RS08790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_RS08795	COG1215	transferase activity, transferring glycosyl groups
IOD66_RS08815	COG0751	glycine-tRNA ligase activity
IOD66_RS08825	COG2852	Protein conserved in bacteria
IOD66_RS08830	COG0752	glycyl-tRNA synthetase alpha subunit
IOD66_RS08870	COG4139	cobalamin transport
IOD66_RS08875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD66_RS08880	COG2850	peptidyl-arginine hydroxylation
IOD66_RS08885	COG0335	large ribosomal subunit rRNA binding
IOD66_RS08890	COG0336	Belongs to the RNA methyltransferase TrmD family
IOD66_RS08895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOD66_RS08900	COG0228	four-way junction DNA binding
IOD66_RS08910	COG0202	RNA polymerase activity
IOD66_RS08915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IOD66_RS08920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IOD66_RS08925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IOD66_RS08930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOD66_RS08935	COG0201	protein transport
IOD66_RS08940	COG0200	Binds to the 23S rRNA
IOD66_RS08945	COG1841	ribosomal large subunit assembly
IOD66_RS08950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IOD66_RS08955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IOD66_RS08960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IOD66_RS08965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IOD66_RS08970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOD66_RS08975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IOD66_RS08980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IOD66_RS08990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IOD66_RS08995	COG0255	Belongs to the universal ribosomal protein uL29 family
IOD66_RS09000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IOD66_RS09005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IOD66_RS09010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IOD66_RS09015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOD66_RS09020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IOD66_RS09025	COG0089	rRNA binding
IOD66_RS09030	COG0088	Forms part of the polypeptide exit tunnel
IOD66_RS09035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IOD66_RS09040	COG0051	transcription antitermination factor activity, RNA binding
IOD66_RS09055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IOD66_RS09060	COG0363	glucosamine-6-phosphate deaminase activity
IOD66_RS09065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD66_RS09075	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IOD66_RS09085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IOD66_RS09090	COG2267	carboxylic ester hydrolase activity
IOD66_RS09100	COG0606	chelatase, subunit chli
IOD66_RS09105	COG3657	addiction module killer protein
IOD66_RS09110	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD66_RS09115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD66_RS09120	COG0737	Belongs to the 5'-nucleotidase family
IOD66_RS09125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOD66_RS09155	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IOD66_RS09160	COG1194	a g-specific adenine glycosylase
IOD66_RS09165	COG0346	lactoylglutathione lyase activity
IOD66_RS09170	COG1489	DNA binding
IOD66_RS09175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IOD66_RS09180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IOD66_RS09200	COG1487	ribonuclease activity
IOD66_RS09220	COG0085	RNA polymerase activity
IOD66_RS09265	COG0222	ribosome binding
IOD66_RS09270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IOD66_RS09275	COG0081	regulation of translation
IOD66_RS09280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IOD66_RS09290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD66_RS09305	COG1297	OPT oligopeptide transporter protein
IOD66_RS09310	COG0758	DNA mediated transformation
IOD66_RS09320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD66_RS09345	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD66_RS09350	COG0235	Class ii aldolase
IOD66_RS09355	COG3623	hexulose-6-phosphate isomerase
IOD66_RS09380	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IOD66_RS09400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD66_RS09405	COG1126	abc transporter atp-binding protein
IOD66_RS09415	COG0765	amino acid transport
IOD66_RS09420	COG3477	response to acidic pH
IOD66_RS09425	COG1454	alcohol dehydrogenase
IOD66_RS09430	COG0738	Major facilitator superfamily
IOD66_RS09435	COG0235	Class ii aldolase
IOD66_RS09440	COG4154	Belongs to the RbsD FucU family
IOD66_RS09445	COG1070	Carbohydrate kinase
IOD66_RS09450	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
IOD66_RS09455	COG1349	DNA-binding transcription factor activity
IOD66_RS09480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD66_RS09480	COG2221	Nitrite and sulphite reductase 4Fe-4S
IOD66_RS09485	COG3381	protein complex oligomerization
IOD66_RS09490	COG3302	dmso reductase anchor subunit
IOD66_RS09495	COG0437	4 iron, 4 sulfur cluster binding
IOD66_RS09500	COG0243	molybdopterin cofactor binding
IOD66_RS09505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD66_RS09510	COG1879	ABC-type sugar transport system periplasmic component
IOD66_RS09515	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD66_RS09525	COG1869	D-ribose catabolic process
IOD66_RS09535	COG1609	Transcriptional regulator
IOD66_RS09540	COG3265	gluconokinase activity
IOD66_RS09545	COG2610	gluconate transmembrane transporter activity
IOD66_RS09550	COG2801	Transposase and inactivated derivatives
IOD66_RS09555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD66_RS09555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_RS09560	COG3715	PTS system
IOD66_RS09565	COG3716	PTS system mannose fructose sorbose family IID component
IOD66_RS09580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD66_RS09585	COG0561	phosphatase activity
IOD66_RS09590	COG0445	tRNA wobble uridine modification
IOD66_RS09595	COG0357	Ribosomal RNA small subunit methyltransferase G
IOD66_RS09615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IOD66_RS09620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD66_RS09625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IOD66_RS09630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IOD66_RS09635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IOD66_RS09640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IOD66_RS09665	COG2168	tRNA wobble position uridine thiolation
IOD66_RS09675	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOD66_RS09680	COG2964	Protein conserved in bacteria
IOD66_RS09685	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD66_RS09690	COG2900	Belongs to the SlyX family
IOD66_RS09695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_RS09700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD66_RS09705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD66_RS09710	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
IOD66_RS09725	COG1349	DNA-binding transcription factor activity
IOD66_RS09730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD66_RS09740	COG0246	Mannitol dehydrogenase
IOD66_RS09745	COG3722	fumarate hydratase activity
IOD66_RS09750	COG0471	metal ion transport
IOD66_RS09750	COG0490	domain, Protein
IOD66_RS09760	COG0583	DNA-binding transcription factor activity
IOD66_RS09765	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
IOD66_RS09770	COG0310	cobalt ion transport
IOD66_RS09775	COG0310	cobalt ion transport
IOD66_RS09780	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IOD66_RS09785	COG1122	ATPase activity
IOD66_RS09795	COG0831	urea catabolic process
IOD66_RS09800	COG0832	Belongs to the urease beta subunit family
IOD66_RS09825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD66_RS09845	COG3691	Protein conserved in bacteria
IOD66_RS09855	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IOD66_RS09860	COG3681	Belongs to the UPF0597 family
IOD66_RS09865	COG0765	amino acid transport
IOD66_RS09870	COG1126	abc transporter atp-binding protein
IOD66_RS09880	COG0799	negative regulation of ribosome biogenesis
IOD66_RS09885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IOD66_RS09890	COG0768	penicillin binding
IOD66_RS09895	COG0772	Belongs to the SEDS family
IOD66_RS09900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD66_RS09905	COG1686	Belongs to the peptidase S11 family
IOD66_RS09910	COG2921	Belongs to the UPF0250 family
IOD66_RS09915	COG0321	lipoyl(octanoyl) transferase activity
IOD66_RS09920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOD66_RS09925	COG1970	mechanosensitive ion channel activity
IOD66_RS09930	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IOD66_RS09935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IOD66_RS09940	COG1739	Uncharacterized protein family UPF0029
IOD66_RS09950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IOD66_RS09955	COG1119	ATPase activity
IOD66_RS10000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IOD66_RS10005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOD66_RS10005	COG0517	IMP dehydrogenase activity
IOD66_RS10015	COG3545	Serine hydrolase
IOD66_RS10050	COG1629	transport
IOD66_RS10050	COG4771	TonB-dependent receptor
IOD66_RS10070	COG0716	FMN binding
IOD66_RS10080	COG1921	L-seryl-tRNASec selenium transferase activity
IOD66_RS10085	COG3276	selenocysteine insertion sequence binding
IOD66_RS10090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IOD66_RS10095	COG0569	domain protein
IOD66_RS10100	COG0268	Binds directly to 16S ribosomal RNA
IOD66_RS10105	COG0728	peptidoglycan biosynthetic process
IOD66_RS10115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IOD66_RS10125	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IOD66_RS10130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD66_RS10135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOD66_RS10145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD66_RS10150	COG2244	polysaccharide biosynthetic process
IOD66_RS10155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD66_RS10160	COG1151	hydroxylamine reductase activity
IOD66_RS10175	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IOD66_RS10215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD66_RS10240	COG4208	sulfate ABC transporter
IOD66_RS10245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOD66_RS10250	COG1304	FMN binding
IOD66_RS10260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IOD66_RS10270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOD66_RS10275	COG2995	paraquat-inducible protein a
IOD66_RS10280	COG1305	Transglutaminase-like
IOD66_RS10290	COG2608	mercury ion transmembrane transporter activity
IOD66_RS10300	COG0583	DNA-binding transcription factor activity
IOD66_RS10305	COG2171	N-acyltransferase activity
IOD66_RS10310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IOD66_RS10320	COG0511	ligase activity, forming carbon-carbon bonds
IOD66_RS10325	COG0439	Biotin carboxylase
IOD66_RS10335	COG3084	Protein conserved in bacteria
IOD66_RS10340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_RS10350	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD66_RS10350	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD66_RS10355	COG0742	ribosomal rna small subunit methyltransferase
IOD66_RS10360	COG1876	peptidase activity
IOD66_RS10365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD66_RS10370	COG1393	Belongs to the ArsC family
IOD66_RS10380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD66_RS10385	COG0564	pseudouridine synthase activity
IOD66_RS10395	COG0668	transmembrane transport
IOD66_RS10400	COG0439	Biotin carboxylase
IOD66_RS10410	COG1025	Belongs to the peptidase M16 family
IOD66_RS10415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IOD66_RS10440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD66_RS10450	COG3120	sequence-specific DNA binding
IOD66_RS10455	COG0180	Tryptophanyl-tRNA synthetase
IOD66_RS10470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IOD66_RS10475	COG0730	response to heat
IOD66_RS10490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOD66_RS10495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IOD66_RS10500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD66_RS10505	COG2116	formate transmembrane transporter activity
IOD66_RS10520	COG0484	heat shock protein binding
IOD66_RS10525	COG0443	Heat shock 70 kDa protein
IOD66_RS10530	COG1070	Carbohydrate kinase
IOD66_RS10535	COG2115	Belongs to the xylose isomerase family
IOD66_RS10540	COG4213	ABC transporter substrate-binding protein
IOD66_RS10545	COG1129	ABC transporter
IOD66_RS10550	COG4214	carbohydrate transport
IOD66_RS10555	COG1609	Transcriptional regulator
IOD66_RS10555	COG2207	Transcriptional regulator
IOD66_RS10560	COG3590	peptidase
IOD66_RS10570	COG4145	pantothenate transmembrane transporter activity
IOD66_RS10575	COG3924	membrane
IOD66_RS10580	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IOD66_RS10585	COG2853	Lipoprotein
IOD66_RS10590	COG0676	glucose-6-phosphate 1-epimerase activity
IOD66_RS10610	COG1649	PFAM Uncharacterised BCR, COG1649
IOD66_RS10610	COG0726	polysaccharide deacetylase
IOD66_RS10625	COG0149	triose-phosphate isomerase activity
IOD66_RS10635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IOD66_RS10640	COG1238	metal cluster binding
IOD66_RS10655	COG1388	LysM domain
IOD66_RS10655	COG4942	peptidase
IOD66_RS10660	COG2818	Glycosylase
IOD66_RS10670	COG0700	Nucleoside recognition
IOD66_RS10680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IOD66_RS10685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IOD66_RS10690	COG0594	ribonuclease P activity
IOD66_RS10695	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD66_RS10700	COG0174	glutamine synthetase
IOD66_RS10705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD66_RS10710	COG0494	nUDIX hydrolase
IOD66_RS10730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOD66_RS10740	COG1490	D-aminoacyl-tRNA deacylase activity
IOD66_RS10745	COG1295	ribonuclease BN
IOD66_RS10750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IOD66_RS10755	COG1629	transport
IOD66_RS10755	COG4771	TonB-dependent receptor
IOD66_RS10790	COG1064	alcohol dehydrogenase
IOD66_RS10800	COG1923	regulation of RNA biosynthetic process
IOD66_RS10805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD66_RS10815	COG1694	Mazg nucleotide pyrophosphohydrolase
IOD66_RS10830	COG1309	transcriptional regulator
IOD66_RS10835	COG0756	dUTP diphosphatase activity
IOD66_RS10840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOD66_RS10845	COG2003	Belongs to the UPF0758 family
IOD66_RS10850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOD66_RS10855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD66_RS10865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD66_RS10870	COG0076	glutamate decarboxylase activity
IOD66_RS10875	COG0425	Belongs to the sulfur carrier protein TusA family
IOD66_RS10880	COG2391	methyltransferase activity
IOD66_RS10885	COG3085	chromosome segregation
IOD66_RS10890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD66_RS10910	COG0598	Magnesium transport protein CorA
IOD66_RS10915	COG2226	methyltransferase
IOD66_RS10925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOD66_RS10930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD66_RS10935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD66_RS10940	COG0805	protein transport
IOD66_RS10955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD66_RS10960	COG1114	Component of the transport system for branched-chain amino acids
IOD66_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
IOD66_RS10970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOD66_RS10975	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOD66_RS10980	COG0142	geranyltranstransferase activity
IOD66_RS10990	COG0431	NADPH-dependent FMN reductase
IOD66_RS10995	COG2259	Doxx family
IOD66_RS11000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IOD66_RS11005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IOD66_RS11010	COG0697	spore germination
IOD66_RS11015	COG4783	chaperone-mediated protein folding
IOD66_RS11025	COG1040	competence protein
IOD66_RS11030	COG2813	Specifically methylates the guanine in position
IOD66_RS11040	COG0456	acetyltransferase
IOD66_RS11045	COG0513	Belongs to the DEAD box helicase family
IOD66_RS11050	COG0259	pyridoxamine-phosphate oxidase activity
IOD66_RS11055	COG0747	negative chemotaxis
IOD66_RS11065	COG1584	GPR1 FUN34 yaaH family protein
IOD66_RS11070	COG1120	ATPase activity
IOD66_RS11075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD66_RS11085	COG4774	siderophore transport
IOD66_RS11095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IOD66_RS11100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOD66_RS11105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IOD66_RS11110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD66_RS11120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOD66_RS11120	COG0131	Imidazoleglycerol-phosphate dehydratase
IOD66_RS11130	COG4804	nuclease activity
IOD66_RS11135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOD66_RS11150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOD66_RS11150	COG0140	phosphoribosyl-ATP diphosphatase activity
IOD66_RS11155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IOD66_RS11160	COG0024	Methionine aminopeptidase
IOD66_RS11175	COG1621	beta-fructofuranosidase activity
IOD66_RS11180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD66_RS11190	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD66_RS11195	COG1136	(ABC) transporter
IOD66_RS11200	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD66_RS11205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD66_RS11235	COG2897	thiosulfate sulfurtransferase activity
IOD66_RS11240	COG2391	methyltransferase activity