locus-tag	class	description
CHY23_RS00015	COG0489	protein tyrosine kinase activity
CHY23_RS00025	COG2095	MarC family integral membrane protein
CHY23_RS00030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHY23_RS00040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CHY23_RS00045	COG2354	Protein conserved in bacteria
CHY23_RS00050	COG3071	HemY protein
CHY23_RS00055	COG2959	enzyme of heme biosynthesis
CHY23_RS00065	COG0181	hydroxymethylbilane synthase activity
CHY23_RS00070	COG1012	belongs to the aldehyde dehydrogenase family
CHY23_RS00070	COG1454	alcohol dehydrogenase
CHY23_RS00085	COG0813	purine-nucleoside phosphorylase activity
CHY23_RS00090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CHY23_RS00095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CHY23_RS00100	COG2364	Membrane
CHY23_RS00105	COG0800	Aldolase
CHY23_RS00110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHY23_RS00115	COG1904	glucuronate isomerase
CHY23_RS00125	COG2186	Transcriptional regulator
CHY23_RS00135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHY23_RS00135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHY23_RS00140	COG1216	Glycosyl transferase, family 2
CHY23_RS00145	COG1216	Glycosyl transferase, family 2
CHY23_RS00155	COG3306	glycosyltransferase involved in LPS biosynthesis
CHY23_RS00165	COG5039	Polysaccharide pyruvyl transferase
CHY23_RS00170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CHY23_RS00175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CHY23_RS00180	COG0077	Prephenate dehydratase
CHY23_RS00180	COG1605	Chorismate mutase
CHY23_RS00185	COG0339	signal peptide processing
CHY23_RS00190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CHY23_RS00195	COG1882	Formate acetyltransferase
CHY23_RS00200	COG2116	formate transmembrane transporter activity
CHY23_RS00205	COG1238	metal cluster binding
CHY23_RS00210	COG0501	Belongs to the peptidase M48B family
CHY23_RS00215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CHY23_RS00220	COG2431	L-lysine efflux transmembrane transporter activity
CHY23_RS00225	COG1169	isochorismate synthase
CHY23_RS00230	COG0436	Aminotransferase
CHY23_RS00240	COG2962	Rard protein
CHY23_RS00260	COG4771	TonB-dependent receptor
CHY23_RS00260	COG1629	transport
CHY23_RS00265	COG0748	coenzyme F420 binding
CHY23_RS00275	COG3088	subunit of a heme lyase
CHY23_RS00275	COG4235	cytochrome complex assembly
CHY23_RS00280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHY23_RS00285	COG1138	Cytochrome C-type biogenesis protein
CHY23_RS00290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHY23_RS00290	COG0475	glutathione-regulated potassium exporter activity
CHY23_RS00300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHY23_RS00315	COG3111	PFAM Bacterial OB fold (BOF) protein
CHY23_RS00330	COG0745	RESPONSE REGULATOR receiver
CHY23_RS00335	COG0642	Histidine kinase
CHY23_RS00340	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CHY23_RS00345	COG1862	Preprotein translocase
CHY23_RS00350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHY23_RS00355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHY23_RS00360	COG1528	Iron-storage protein
CHY23_RS00365	COG1528	Iron-storage protein
CHY23_RS00370	COG2252	PERMEase
CHY23_RS00375	COG0424	maF-like protein
CHY23_RS00390	COG0583	DNA-binding transcription factor activity
CHY23_RS00405	COG1373	ATPase (AAA superfamily
CHY23_RS00420	COG1902	pentaerythritol trinitrate reductase activity
CHY23_RS00425	COG0301	tRNA thio-modification
CHY23_RS00425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHY23_RS00430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CHY23_RS00440	COG0330	HflC and HflK could
CHY23_RS00445	COG0330	HflC and HflK could
CHY23_RS00450	COG3118	belongs to the thioredoxin family
CHY23_RS00460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CHY23_RS00470	COG0531	amino acid
CHY23_RS00475	COG0531	amino acid
CHY23_RS00490	COG3047	cAMP biosynthetic process
CHY23_RS00495	COG0542	response to heat
CHY23_RS00500	COG0798	PFAM Bile acid sodium symporter
CHY23_RS00505	COG1393	Belongs to the ArsC family
CHY23_RS00515	COG1027	Aspartate ammonia-lyase
CHY23_RS00525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CHY23_RS00530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CHY23_RS00530	COG3583	domain protein
CHY23_RS00530	COG3064	Membrane
CHY23_RS00540	COG0720	synthase
CHY23_RS00545	COG0602	queuosine metabolic process
CHY23_RS00570	COG0795	lipopolysaccharide-transporting ATPase activity
CHY23_RS00575	COG0795	lipopolysaccharide-transporting ATPase activity
CHY23_RS00585	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CHY23_RS00590	COG2937	Belongs to the GPAT DAPAT family
CHY23_RS00595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CHY23_RS00600	COG3066	DNA modification
CHY23_RS00605	COG0861	Integral membrane protein TerC family
CHY23_RS00610	COG1472	Belongs to the glycosyl hydrolase 3 family
CHY23_RS00615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHY23_RS00620	COG0148	phosphopyruvate hydratase activity
CHY23_RS00625	COG1051	belongs to the nudix hydrolase family
CHY23_RS00630	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
CHY23_RS00640	COG1965	Belongs to the frataxin family
CHY23_RS00655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CHY23_RS00660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CHY23_RS00665	COG0564	pseudouridine synthase activity
CHY23_RS00675	COG0205	6-phosphofructokinase activity
CHY23_RS00680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CHY23_RS00685	COG1525	nuclease
CHY23_RS00690	COG1115	amino acid carrier protein
CHY23_RS00695	COG0628	permease
CHY23_RS00705	COG0826	peptidase U32
CHY23_RS00710	COG3307	-O-antigen
CHY23_RS00715	COG1519	Transferase
CHY23_RS00725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CHY23_RS00730	COG0802	atpase or kinase
CHY23_RS00735	COG1388	LysM domain
CHY23_RS00735	COG0860	N-Acetylmuramoyl-L-alanine amidase
CHY23_RS00740	COG0166	Belongs to the GPI family
CHY23_RS00745	COG2960	long-chain fatty acid transporting porin activity
CHY23_RS00770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CHY23_RS00780	COG0551	DNA topoisomerase type I activity
CHY23_RS00790	COG2137	regulation of response to DNA damage stimulus
CHY23_RS00795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CHY23_RS00800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHY23_RS00810	COG1322	Protein conserved in bacteria
CHY23_RS00815	COG0512	Glutamine amidotransferase of anthranilate synthase
CHY23_RS00825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CHY23_RS00830	COG0494	nUDIX hydrolase
CHY23_RS00845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CHY23_RS00850	COG0612	Peptidase, M16
CHY23_RS00860	COG0471	metal ion transport
CHY23_RS00865	COG0583	DNA-binding transcription factor activity
CHY23_RS00870	COG3266	domain, Protein
CHY23_RS00875	COG1187	pseudouridine synthase activity
CHY23_RS00880	COG0009	L-threonylcarbamoyladenylate synthase
CHY23_RS00890	COG2837	iron assimilation
CHY23_RS00895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CHY23_RS00900	COG0512	Glutamine amidotransferase of anthranilate synthase
CHY23_RS00910	COG2226	methyltransferase
CHY23_RS00915	COG2268	Band 7 protein
CHY23_RS00920	COG2841	Protein conserved in bacteria
CHY23_RS00935	COG2965	DNA replication, synthesis of RNA primer
CHY23_RS00950	COG3201	nicotinamide mononucleotide transporter
CHY23_RS00955	COG2976	Protein conserved in bacteria
CHY23_RS00965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CHY23_RS00970	COG1426	Protein conserved in bacteria
CHY23_RS00975	COG0659	secondary active sulfate transmembrane transporter activity
CHY23_RS00985	COG0673	inositol 2-dehydrogenase activity
CHY23_RS00990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHY23_RS00990	COG0475	glutathione-regulated potassium exporter activity
CHY23_RS01035	COG1764	response to oxidative stress
CHY23_RS01065	COG2207	Transcriptional regulator
CHY23_RS01075	COG1902	pentaerythritol trinitrate reductase activity
CHY23_RS01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHY23_RS01085	COG2084	Dehydrogenase
CHY23_RS01090	COG0778	Nitroreductase
CHY23_RS01095	COG2095	MarC family integral membrane protein
CHY23_RS01110	COG0625	glutathione transferase activity
CHY23_RS01125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CHY23_RS01130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CHY23_RS01145	COG1275	C4-dicarboxylate transporter malic acid transport protein
CHY23_RS01150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHY23_RS01165	COG1132	(ABC) transporter
CHY23_RS01170	COG1854	S-ribosylhomocysteine lyase activity
CHY23_RS01175	COG3008	intermembrane lipid transfer
CHY23_RS01180	COG0735	belongs to the Fur family
CHY23_RS01185	COG0716	FMN binding
CHY23_RS01195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CHY23_RS01200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CHY23_RS01205	COG2252	PERMEase
CHY23_RS01210	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CHY23_RS01215	COG2081	HI0933 family
CHY23_RS01220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CHY23_RS01230	COG0560	Phosphoserine phosphatase
CHY23_RS01245	COG0058	SHG alpha-glucan phosphorylase activity
CHY23_RS01250	COG2909	trisaccharide binding
CHY23_RS01260	COG4580	involved in the transport of maltose and maltodextrins
CHY23_RS01265	COG3842	ATPase activity
CHY23_RS01280	COG3833	ABC-type maltose transport systems, permease component
CHY23_RS01285	COG1640	4-alpha-glucanotransferase
CHY23_RS01290	COG1966	Carbon starvation protein
CHY23_RS01295	COG0084	hydrolase, TatD family'
CHY23_RS01300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHY23_RS01310	COG0778	Nitroreductase
CHY23_RS01325	COG4172	Belongs to the ABC transporter superfamily
CHY23_RS01330	COG0191	fructose-bisphosphate aldolase activity
CHY23_RS01335	COG0126	phosphoglycerate kinase activity
CHY23_RS01340	COG0471	metal ion transport
CHY23_RS01345	COG0471	metal ion transport
CHY23_RS01350	COG0471	metal ion transport
CHY23_RS01355	COG0187	DNA topoisomerase II activity
CHY23_RS01360	COG5002	protein histidine kinase activity
CHY23_RS01365	COG0745	RESPONSE REGULATOR receiver
CHY23_RS01390	COG0789	Transcriptional regulator
CHY23_RS01410	COG0300	oxidoreductase activity
CHY23_RS01415	COG0778	Nitroreductase
CHY23_RS01420	COG0616	signal peptide processing
CHY23_RS01425	COG3719	Belongs to the RNase T2 family
CHY23_RS01435	COG1252	NADH dehydrogenase
CHY23_RS01440	COG2183	response to ionizing radiation
CHY23_RS01445	COG3063	Type IV pilus biogenesis stability protein PilW
CHY23_RS01450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CHY23_RS01485	COG2161	toxin-antitoxin pair type II binding
CHY23_RS01490	COG4115	mRNA cleavage
CHY23_RS01495	COG2835	tetraacyldisaccharide 4'-kinase activity
CHY23_RS01505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CHY23_RS01510	COG0740	serine-type endopeptidase activity
CHY23_RS01515	COG2166	iron-sulfur cluster assembly
CHY23_RS01535	COG0488	(ABC) transporter
CHY23_RS01540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CHY23_RS01555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CHY23_RS01560	COG5007	Belongs to the BolA IbaG family
CHY23_RS01570	COG2854	intermembrane phospholipid transfer
CHY23_RS01575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CHY23_RS01580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CHY23_RS01585	COG1127	ABC transporter
CHY23_RS01590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHY23_RS01595	COG1090	epimerase
CHY23_RS01615	COG0563	adenylate kinase activity
CHY23_RS01625	COG2814	Major facilitator Superfamily
CHY23_RS01655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CHY23_RS01670	COG2814	Major facilitator Superfamily
CHY23_RS01675	COG0363	glucosamine-6-phosphate deaminase activity
CHY23_RS01680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CHY23_RS01685	COG1218	3'(2'),5'-bisphosphate nucleotidase
CHY23_RS01690	COG0494	nUDIX hydrolase
CHY23_RS01695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CHY23_RS01700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CHY23_RS01705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CHY23_RS01710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CHY23_RS01725	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CHY23_RS01730	COG1178	ABC-type Fe3 transport system permease component
CHY23_RS01735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHY23_RS01740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHY23_RS01745	COG2190	(PTS) system
CHY23_RS01755	COG0210	DNA helicase
CHY23_RS01760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CHY23_RS01765	COG0409	Hydrogenase expression formation protein
CHY23_RS01770	COG0309	Hydrogenase expression formation protein (HypE)
CHY23_RS01775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CHY23_RS01780	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CHY23_RS01785	COG0437	4 iron, 4 sulfur cluster binding
CHY23_RS01790	COG5557	Pfam Polysulphide reductase, NrfD
CHY23_RS01795	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CHY23_RS01800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CHY23_RS01805	COG1773	rubredoxin
CHY23_RS01810	COG0298	carbon dioxide binding
CHY23_RS01815	COG0375	protein maturation
CHY23_RS01850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CHY23_RS01855	COG0308	aminopeptidase N
CHY23_RS01860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CHY23_RS01865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CHY23_RS01870	COG0295	cytidine deaminase activity
CHY23_RS01875	COG2177	Part of the ABC transporter FtsEX involved in
CHY23_RS01880	COG2884	Cell division ATP-binding protein ftsE
CHY23_RS01885	COG0552	protein localization to endoplasmic reticulum
CHY23_RS01890	COG0742	ribosomal rna small subunit methyltransferase
CHY23_RS01895	COG3099	Belongs to the UPF0263 family
CHY23_RS01900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CHY23_RS01910	COG4160	amino acid transport
CHY23_RS01915	COG4215	(ABC) transporter
CHY23_RS01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHY23_RS01925	COG1126	abc transporter atp-binding protein
CHY23_RS01930	COG1881	PFAM PEBP family protein
CHY23_RS01940	COG3620	sequence-specific DNA binding
CHY23_RS01950	COG4232	protein-disulfide reductase activity
CHY23_RS01955	COG3101	peptidyl-lysine hydroxylation
CHY23_RS01965	COG3107	peptidoglycan biosynthetic process
CHY23_RS01970	COG0792	nuclease activity
CHY23_RS01975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CHY23_RS02005	COG1138	Cytochrome C-type biogenesis protein
CHY23_RS02015	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHY23_RS02020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHY23_RS02025	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHY23_RS02030	COG4133	protoheme IX ABC transporter activity
CHY23_RS02035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHY23_RS02065	COG3630	sodium ion export across plasma membrane
CHY23_RS02075	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CHY23_RS02080	COG2824	Alkylphosphonate utilization operon protein PhnA
CHY23_RS02085	COG1858	cytochrome C peroxidase
CHY23_RS02090	COG1872	DUF167
CHY23_RS02095	COG0762	integral membrane protein
CHY23_RS02100	COG3171	Protein conserved in bacteria
CHY23_RS02105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CHY23_RS02110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHY23_RS02115	COG0416	fatty acid biosynthetic process
CHY23_RS02120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CHY23_RS02125	COG1399	metal-binding, possibly nucleic acid-binding protein
CHY23_RS02130	COG4137	Cytochrome C assembly protein
CHY23_RS02135	COG4536	flavin adenine dinucleotide binding
CHY23_RS02140	COG0733	neurotransmitter:sodium symporter activity
CHY23_RS02150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHY23_RS02150	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHY23_RS02155	COG3715	PTS system
CHY23_RS02160	COG3716	PTS system mannose fructose sorbose family IID component
CHY23_RS02200	COG1840	ABC-type Fe3 transport system, periplasmic component
CHY23_RS02215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHY23_RS02230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHY23_RS02230	COG0678	peroxiredoxin activity
CHY23_RS02235	COG0583	DNA-binding transcription factor activity
CHY23_RS02240	COG1309	transcriptional regulator
CHY23_RS02245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHY23_RS02250	COG0557	exoribonuclease II activity
CHY23_RS02260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CHY23_RS02265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHY23_RS02275	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CHY23_RS02280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHY23_RS02345	COG0316	Belongs to the HesB IscA family
CHY23_RS02350	COG1575	Belongs to the MenA family. Type 1 subfamily
CHY23_RS02355	COG1720	tRNA m6t6A37 methyltransferase activity
CHY23_RS02365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CHY23_RS02380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHY23_RS02385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CHY23_RS02390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHY23_RS02405	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CHY23_RS02415	COG1755	Isoprenylcysteine carboxyl methyltransferase
CHY23_RS02425	COG1530	ribonuclease E activity
CHY23_RS02440	COG2249	NAD(P)H dehydrogenase (quinone) activity
CHY23_RS02445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CHY23_RS02455	COG0243	molybdopterin cofactor binding
CHY23_RS02460	COG0437	4 iron, 4 sulfur cluster binding
CHY23_RS02465	COG0348	domain, Protein
CHY23_RS02470	COG3043	anaerobic respiration
CHY23_RS02475	COG3005	denitrification pathway
CHY23_RS02485	COG2050	protein possibly involved in aromatic compounds catabolism
CHY23_RS02490	COG0277	FAD linked oxidase domain protein
CHY23_RS02490	COG0247	lactate metabolic process
CHY23_RS02495	COG2885	chlorophyll binding
CHY23_RS02495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CHY23_RS02500	COG1879	ABC-type sugar transport system periplasmic component
CHY23_RS02505	COG1129	ABC transporter
CHY23_RS02510	COG4211	Belongs to the binding-protein-dependent transport system permease family
CHY23_RS02535	COG1022	Amp-dependent synthetase and ligase
CHY23_RS02540	COG4989	oxidoreductase activity
CHY23_RS02545	COG3691	Protein conserved in bacteria
CHY23_RS02550	COG0814	amino acid
CHY23_RS02570	COG4974	Belongs to the 'phage' integrase family
CHY23_RS02575	COG0732	type I restriction modification DNA specificity domain
CHY23_RS02600	COG1555	photosystem II stabilization
CHY23_RS02605	COG3061	Opacity-associated protein A
CHY23_RS02605	COG3266	domain, Protein
CHY23_RS02615	COG0859	PFAM glycosyl transferase family 9
CHY23_RS02620	COG0859	PFAM glycosyl transferase family 9
CHY23_RS02625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CHY23_RS02630	COG0049	tRNA binding
CHY23_RS02635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHY23_RS02640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHY23_RS02670	COG0825	malonyl-CoA metabolic process
CHY23_RS02680	COG0204	Acyl-transferase
CHY23_RS02685	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CHY23_RS02710	COG0783	Belongs to the Dps family
CHY23_RS02725	COG1289	transmembrane transporter activity
CHY23_RS02730	COG1803	Methylglyoxal synthase
CHY23_RS02735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CHY23_RS02745	COG0525	valine-tRNA ligase activity
CHY23_RS02755	COG2153	protein acetylation
CHY23_RS02760	COG2927	DNA polymerase III (CHI subunit)
CHY23_RS02765	COG1652	LysM domain
CHY23_RS02775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHY23_RS02780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CHY23_RS02785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CHY23_RS02790	COG1045	serine acetyltransferase
CHY23_RS02795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHY23_RS02820	COG1072	(Pantothenic acid kinase))
CHY23_RS02825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHY23_RS02840	COG0521	Mo-molybdopterin cofactor biosynthetic process
CHY23_RS02850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CHY23_RS02855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CHY23_RS02860	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CHY23_RS02875	COG0625	glutathione transferase activity
CHY23_RS02880	COG0019	diaminopimelate decarboxylase activity
CHY23_RS02890	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CHY23_RS02895	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CHY23_RS02900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CHY23_RS02905	COG1053	succinate dehydrogenase
CHY23_RS02910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CHY23_RS02915	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CHY23_RS02920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CHY23_RS02925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CHY23_RS02935	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CHY23_RS02940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CHY23_RS02945	COG2264	protein methyltransferase activity
CHY23_RS02965	COG0037	tRNA processing
CHY23_RS02975	COG4974	Belongs to the 'phage' integrase family
CHY23_RS03035	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CHY23_RS03050	COG1151	hydroxylamine reductase activity
CHY23_RS03055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CHY23_RS03060	COG2244	polysaccharide biosynthetic process
CHY23_RS03065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CHY23_RS03075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CHY23_RS03080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CHY23_RS03110	COG0728	peptidoglycan biosynthetic process
CHY23_RS03115	COG0268	Binds directly to 16S ribosomal RNA
CHY23_RS03120	COG0569	domain protein
CHY23_RS03125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHY23_RS03130	COG3276	selenocysteine insertion sequence binding
CHY23_RS03145	COG0716	FMN binding
CHY23_RS03170	COG1629	transport
CHY23_RS03170	COG4771	TonB-dependent receptor
CHY23_RS03195	COG2431	L-lysine efflux transmembrane transporter activity
CHY23_RS03205	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CHY23_RS03210	COG3545	Serine hydrolase
CHY23_RS03245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CHY23_RS03245	COG1215	transferase activity, transferring glycosyl groups
CHY23_RS03290	COG1739	Uncharacterized protein family UPF0029
CHY23_RS03295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHY23_RS03300	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CHY23_RS03305	COG1970	mechanosensitive ion channel activity
CHY23_RS03310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CHY23_RS03315	COG0321	lipoyl(octanoyl) transferase activity
CHY23_RS03320	COG2921	Belongs to the UPF0250 family
CHY23_RS03325	COG1686	Belongs to the peptidase S11 family
CHY23_RS03330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CHY23_RS03335	COG0772	Belongs to the SEDS family
CHY23_RS03340	COG0768	penicillin binding
CHY23_RS03345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CHY23_RS03350	COG0799	negative regulation of ribosome biogenesis
CHY23_RS03360	COG1126	abc transporter atp-binding protein
CHY23_RS03365	COG0765	amino acid transport
CHY23_RS03370	COG3681	Belongs to the UPF0597 family
CHY23_RS03375	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CHY23_RS03385	COG3691	Protein conserved in bacteria
CHY23_RS03435	COG0831	urea catabolic process
CHY23_RS03445	COG1122	ATPase activity
CHY23_RS03450	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CHY23_RS03455	COG0310	cobalt ion transport
CHY23_RS03460	COG0310	cobalt ion transport
CHY23_RS03465	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CHY23_RS03470	COG0583	DNA-binding transcription factor activity
CHY23_RS03480	COG0490	domain, Protein
CHY23_RS03480	COG0471	metal ion transport
CHY23_RS03485	COG3722	fumarate hydratase activity
CHY23_RS03500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CHY23_RS03505	COG1349	DNA-binding transcription factor activity
CHY23_RS03520	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CHY23_RS03530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CHY23_RS03535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHY23_RS03540	COG2900	Belongs to the SlyX family
CHY23_RS03545	COG0545	Peptidyl-prolyl cis-trans isomerase
CHY23_RS03550	COG2964	Protein conserved in bacteria
CHY23_RS03555	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CHY23_RS03565	COG2168	tRNA wobble position uridine thiolation
CHY23_RS03595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CHY23_RS03600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CHY23_RS03605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CHY23_RS03610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHY23_RS03635	COG0357	Ribosomal RNA small subunit methyltransferase G
CHY23_RS03640	COG0445	tRNA wobble uridine modification
CHY23_RS03645	COG0561	phosphatase activity
CHY23_RS03650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHY23_RS03655	COG3012	SEC-C Motif Domain Protein
CHY23_RS03665	COG3716	PTS system mannose fructose sorbose family IID component
CHY23_RS03670	COG3715	PTS system
CHY23_RS03675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHY23_RS03675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHY23_RS03680	COG2610	gluconate transmembrane transporter activity
CHY23_RS03685	COG3265	gluconokinase activity
CHY23_RS03690	COG1609	Transcriptional regulator
CHY23_RS03695	COG1609	Transcriptional regulator
CHY23_RS03710	COG1172	Belongs to the binding-protein-dependent transport system permease family
CHY23_RS03715	COG1879	ABC-type sugar transport system periplasmic component
CHY23_RS03720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHY23_RS03725	COG0243	molybdopterin cofactor binding
CHY23_RS03730	COG0437	4 iron, 4 sulfur cluster binding
CHY23_RS03735	COG3302	dmso reductase anchor subunit
CHY23_RS03740	COG3381	protein complex oligomerization
CHY23_RS03745	COG2221	Nitrite and sulphite reductase 4Fe-4S
CHY23_RS03745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CHY23_RS03770	COG1349	DNA-binding transcription factor activity
CHY23_RS03775	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
CHY23_RS03785	COG4154	Belongs to the RbsD FucU family
CHY23_RS03790	COG0235	Class ii aldolase
CHY23_RS03795	COG0738	Major facilitator superfamily
CHY23_RS03800	COG1454	alcohol dehydrogenase
CHY23_RS03805	COG3477	response to acidic pH
CHY23_RS03810	COG0765	amino acid transport
CHY23_RS03820	COG1126	abc transporter atp-binding protein
CHY23_RS03825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHY23_RS03845	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CHY23_RS03870	COG3623	hexulose-6-phosphate isomerase
CHY23_RS03875	COG0235	Class ii aldolase
CHY23_RS03880	COG0545	Peptidyl-prolyl cis-trans isomerase
CHY23_RS03900	COG4783	chaperone-mediated protein folding
CHY23_RS03910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CHY23_RS03920	COG0758	DNA mediated transformation
CHY23_RS03925	COG1297	OPT oligopeptide transporter protein
CHY23_RS03940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CHY23_RS03950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CHY23_RS03955	COG0081	regulation of translation
CHY23_RS03960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CHY23_RS03965	COG0222	ribosome binding
CHY23_RS04030	COG1487	ribonuclease activity
CHY23_RS04045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CHY23_RS04050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CHY23_RS04060	COG0346	lactoylglutathione lyase activity
CHY23_RS04065	COG1194	a g-specific adenine glycosylase
CHY23_RS04070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CHY23_RS04075	COG0741	lytic transglycosylase activity
CHY23_RS04100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CHY23_RS04105	COG0737	Belongs to the 5'-nucleotidase family
CHY23_RS04110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CHY23_RS04115	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHY23_RS04120	COG0606	chelatase, subunit chli
CHY23_RS04130	COG2267	carboxylic ester hydrolase activity
CHY23_RS04135	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CHY23_RS04145	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CHY23_RS04155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHY23_RS04160	COG0363	glucosamine-6-phosphate deaminase activity
CHY23_RS04165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CHY23_RS04180	COG0051	transcription antitermination factor activity, RNA binding
CHY23_RS04185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CHY23_RS04190	COG0088	Forms part of the polypeptide exit tunnel
CHY23_RS04195	COG0089	rRNA binding
CHY23_RS04200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CHY23_RS04205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CHY23_RS04210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CHY23_RS04215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CHY23_RS04220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CHY23_RS04225	COG0255	Belongs to the universal ribosomal protein uL29 family
CHY23_RS04230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CHY23_RS04240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CHY23_RS04245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CHY23_RS04250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CHY23_RS04255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CHY23_RS04260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CHY23_RS04265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CHY23_RS04270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CHY23_RS04275	COG1841	ribosomal large subunit assembly
CHY23_RS04280	COG0200	Binds to the 23S rRNA
CHY23_RS04285	COG0201	protein transport
CHY23_RS04295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CHY23_RS04300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CHY23_RS04305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CHY23_RS04310	COG0202	RNA polymerase activity
CHY23_RS04320	COG0228	four-way junction DNA binding
CHY23_RS04325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CHY23_RS04330	COG0336	Belongs to the RNA methyltransferase TrmD family
CHY23_RS04335	COG0335	large ribosomal subunit rRNA binding
CHY23_RS04340	COG2850	peptidyl-arginine hydroxylation
CHY23_RS04345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CHY23_RS04350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHY23_RS04355	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CHY23_RS04395	COG2852	Protein conserved in bacteria
CHY23_RS04420	COG2832	Protein of unknown function (DUF454)
CHY23_RS04425	COG1215	transferase activity, transferring glycosyl groups
CHY23_RS04430	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CHY23_RS04440	COG0084	hydrolase, TatD family'
CHY23_RS04460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHY23_RS04470	COG0470	DNA polymerase III
CHY23_RS04475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CHY23_RS04480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CHY23_RS04500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHY23_RS04505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CHY23_RS04510	COG0254	rRNA binding
CHY23_RS04515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CHY23_RS04520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHY23_RS04525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CHY23_RS04530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHY23_RS04540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CHY23_RS04555	COG0442	prolyl-tRNA aminoacylation
CHY23_RS04565	COG1595	DNA-templated transcription, initiation
CHY23_RS04570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CHY23_RS04580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHY23_RS04595	COG0582	viral genome integration into host DNA
CHY23_RS04615	COG0786	glutamate:sodium symporter activity
CHY23_RS04630	COG0640	Transcriptional regulator
CHY23_RS04665	COG2831	hemolysin activation secretion protein
CHY23_RS04670	COG3210	domain, Protein
CHY23_RS04670	COG3210	domain, Protein
CHY23_RS04695	COG3311	Transcriptional regulator
CHY23_RS04710	COG2502	aspartate--ammonia ligase
CHY23_RS04715	COG1522	sequence-specific DNA binding
CHY23_RS04720	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CHY23_RS04725	COG3161	chorismate lyase activity
CHY23_RS04790	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CHY23_RS04800	COG4208	sulfate ABC transporter
CHY23_RS04805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CHY23_RS04815	COG1304	FMN binding
CHY23_RS04825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CHY23_RS04835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CHY23_RS04840	COG2995	paraquat-inducible protein a
CHY23_RS04845	COG1305	Transglutaminase-like
CHY23_RS04855	COG2608	mercury ion transmembrane transporter activity
CHY23_RS04860	COG1979	alcohol dehydrogenase
CHY23_RS04865	COG0583	DNA-binding transcription factor activity
CHY23_RS04870	COG2171	N-acyltransferase activity
CHY23_RS04875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CHY23_RS04885	COG0511	ligase activity, forming carbon-carbon bonds
CHY23_RS04890	COG0439	Biotin carboxylase
CHY23_RS04895	COG1763	Mo-molybdopterin cofactor biosynthetic process
CHY23_RS04900	COG3084	Protein conserved in bacteria
CHY23_RS04905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHY23_RS04915	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CHY23_RS04915	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CHY23_RS04925	COG1876	peptidase activity
CHY23_RS04930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHY23_RS04935	COG1393	Belongs to the ArsC family
CHY23_RS04945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CHY23_RS04950	COG0564	pseudouridine synthase activity
CHY23_RS04960	COG0668	transmembrane transport
CHY23_RS04965	COG0439	Biotin carboxylase
CHY23_RS04975	COG1025	Belongs to the peptidase M16 family
CHY23_RS04980	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CHY23_RS05005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHY23_RS05010	COG1067	ATP-dependent peptidase activity
CHY23_RS05015	COG3120	sequence-specific DNA binding
CHY23_RS05020	COG0180	Tryptophanyl-tRNA synthetase
CHY23_RS05040	COG0730	response to heat
CHY23_RS05055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CHY23_RS05065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CHY23_RS05070	COG2116	formate transmembrane transporter activity
CHY23_RS05095	COG0443	Heat shock 70 kDa protein
CHY23_RS05100	COG1070	Carbohydrate kinase
CHY23_RS05105	COG2115	Belongs to the xylose isomerase family
CHY23_RS05110	COG4213	ABC transporter substrate-binding protein
CHY23_RS05115	COG1129	ABC transporter
CHY23_RS05120	COG4214	carbohydrate transport
CHY23_RS05125	COG2207	Transcriptional regulator
CHY23_RS05125	COG1609	Transcriptional regulator
CHY23_RS05130	COG3590	peptidase
CHY23_RS05140	COG4145	pantothenate transmembrane transporter activity
CHY23_RS05145	COG3924	membrane
CHY23_RS05150	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CHY23_RS05155	COG2853	Lipoprotein
CHY23_RS05160	COG0676	glucose-6-phosphate 1-epimerase activity
CHY23_RS05175	COG1649	PFAM Uncharacterised BCR, COG1649
CHY23_RS05175	COG0726	polysaccharide deacetylase
CHY23_RS05180	COG1215	transferase activity, transferring glycosyl groups
CHY23_RS05190	COG0149	triose-phosphate isomerase activity
CHY23_RS05200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CHY23_RS05205	COG1238	metal cluster binding
CHY23_RS05220	COG4942	peptidase
CHY23_RS05220	COG1388	LysM domain
CHY23_RS05225	COG2818	Glycosylase
CHY23_RS05235	COG0700	Nucleoside recognition
CHY23_RS05240	COG3366	ferrous iron transmembrane transporter activity
CHY23_RS05245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CHY23_RS05250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CHY23_RS05255	COG0594	ribonuclease P activity
CHY23_RS05260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CHY23_RS05265	COG0174	glutamine synthetase
CHY23_RS05270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CHY23_RS05275	COG0494	nUDIX hydrolase
CHY23_RS05305	COG1490	D-aminoacyl-tRNA deacylase activity
CHY23_RS05310	COG1295	ribonuclease BN
CHY23_RS05315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CHY23_RS05340	COG1064	alcohol dehydrogenase
CHY23_RS05350	COG1923	regulation of RNA biosynthetic process
CHY23_RS05355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHY23_RS05365	COG1694	Mazg nucleotide pyrophosphohydrolase
CHY23_RS05390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CHY23_RS05395	COG2003	Belongs to the UPF0758 family
CHY23_RS05400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CHY23_RS05405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHY23_RS05415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CHY23_RS05420	COG0076	glutamate decarboxylase activity
CHY23_RS05425	COG0425	Belongs to the sulfur carrier protein TusA family
CHY23_RS05430	COG2391	methyltransferase activity
CHY23_RS05435	COG3085	chromosome segregation
CHY23_RS05455	COG0598	Magnesium transport protein CorA
CHY23_RS05460	COG2226	methyltransferase
CHY23_RS05470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CHY23_RS05475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHY23_RS05480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHY23_RS05485	COG0805	protein transport
CHY23_RS05505	COG1114	Component of the transport system for branched-chain amino acids
CHY23_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
CHY23_RS05515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CHY23_RS05520	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CHY23_RS05525	COG0142	geranyltranstransferase activity
CHY23_RS05535	COG0431	NADPH-dependent FMN reductase
CHY23_RS05540	COG2259	Doxx family
CHY23_RS05545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CHY23_RS05550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CHY23_RS05555	COG0697	spore germination
CHY23_RS05560	COG4783	chaperone-mediated protein folding
CHY23_RS05570	COG1040	competence protein
CHY23_RS05585	COG0456	acetyltransferase
CHY23_RS05590	COG0513	Belongs to the DEAD box helicase family
CHY23_RS05600	COG0747	negative chemotaxis
CHY23_RS05610	COG1584	GPR1 FUN34 yaaH family protein
CHY23_RS05615	COG1120	ATPase activity
CHY23_RS05650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CHY23_RS05655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CHY23_RS05675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CHY23_RS05690	COG0140	phosphoribosyl-ATP diphosphatase activity
CHY23_RS05690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CHY23_RS05695	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CHY23_RS05700	COG0024	Methionine aminopeptidase
CHY23_RS05715	COG1621	beta-fructofuranosidase activity
CHY23_RS05720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHY23_RS05730	COG4591	ABC-type transport system involved in lipoprotein release permease component
CHY23_RS05735	COG1136	(ABC) transporter
CHY23_RS05740	COG4591	ABC-type transport system involved in lipoprotein release permease component
CHY23_RS05745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHY23_RS05775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHY23_RS05780	COG0592	DNA-directed DNA polymerase activity
CHY23_RS05795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CHY23_RS05810	COG0616	signal peptide processing
CHY23_RS05825	COG3116	cell division
CHY23_RS05830	COG0768	penicillin binding
CHY23_RS05835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CHY23_RS05840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHY23_RS05850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CHY23_RS05855	COG0772	Belongs to the SEDS family
CHY23_RS05865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHY23_RS05870	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHY23_RS05880	COG0849	cell division
CHY23_RS05885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CHY23_RS05890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CHY23_RS05895	COG0497	DNA recombination
CHY23_RS05900	COG4172	Belongs to the ABC transporter superfamily
CHY23_RS05905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHY23_RS05910	COG0601	transmembrane transport
CHY23_RS05935	COG0193	aminoacyl-tRNA hydrolase activity
CHY23_RS05940	COG0012	GTP binding
CHY23_RS05945	COG2020	methyltransferase activity
CHY23_RS05955	COG3133	Outer membrane lipoprotein
CHY23_RS05960	COG3102	Protein conserved in bacteria
CHY23_RS05965	COG0018	arginyl-trna synthetase
CHY23_RS05980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHY23_RS05985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHY23_RS05990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CHY23_RS05995	COG0196	riboflavin kinase activity
CHY23_RS06000	COG3172	ATPase kinase involved in NAD metabolism
CHY23_RS06005	COG2129	metallophosphoesterase
CHY23_RS06010	COG0745	RESPONSE REGULATOR receiver
CHY23_RS06020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CHY23_RS06025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CHY23_RS06035	COG1217	gtp-binding protein TYPA
CHY23_RS06040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHY23_RS06050	COG1561	YicC-like family, N-terminal region
CHY23_RS06055	COG0354	folic acid binding
CHY23_RS06060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CHY23_RS06065	COG2197	response regulator
CHY23_RS06075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CHY23_RS06110	COG0747	negative chemotaxis
CHY23_RS06115	COG0747	negative chemotaxis
CHY23_RS06120	COG0601	transmembrane transport
CHY23_RS06125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHY23_RS06130	COG0444	Belongs to the ABC transporter superfamily
CHY23_RS06135	COG4608	Belongs to the ABC transporter superfamily
CHY23_RS06150	COG0251	oxidation-reduction process
CHY23_RS06155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHY23_RS06160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CHY23_RS06165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CHY23_RS06170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CHY23_RS06175	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CHY23_RS06180	COG0848	biopolymer transport protein
CHY23_RS06185	COG0811	peptide transport
CHY23_RS06190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHY23_RS06195	COG3118	belongs to the thioredoxin family
CHY23_RS06200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHY23_RS06200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHY23_RS06200	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CHY23_RS06205	COG1461	Dihydroxyacetone kinase
CHY23_RS06210	COG2376	Dihydroxyacetone kinase
CHY23_RS06215	COG0492	ferredoxin-NADP+ reductase activity
CHY23_RS06220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CHY23_RS06225	COG3753	Protein conserved in bacteria
CHY23_RS06245	COG3030	protein affecting phage T7 exclusion by the F plasmid
CHY23_RS06250	COG0006	proline dipeptidase activity
CHY23_RS06260	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CHY23_RS06280	COG0129	dihydroxy-acid dehydratase activity
CHY23_RS06285	COG3978	acetolactate synthase activity
CHY23_RS06300	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CHY23_RS06305	COG0437	4 iron, 4 sulfur cluster binding
CHY23_RS06310	COG3301	Polysulphide reductase, NrfD
CHY23_RS06355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHY23_RS06360	COG1414	Transcriptional regulator
CHY23_RS06365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CHY23_RS06375	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CHY23_RS06385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CHY23_RS06390	COG3068	Protein conserved in bacteria
CHY23_RS06415	COG1278	Cold shock
CHY23_RS06420	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CHY23_RS06425	COG0793	Belongs to the peptidase S41A family
CHY23_RS06430	COG2989	Protein conserved in bacteria
CHY23_RS06435	COG3108	Peptidase M15
CHY23_RS06440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHY23_RS06455	COG0537	adenosine 5'-monophosphoramidase activity
CHY23_RS06460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHY23_RS06465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHY23_RS06470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHY23_RS06475	COG1162	GTPase activity
CHY23_RS06480	COG0583	DNA-binding transcription factor activity
CHY23_RS06485	COG1011	Hydrolase
CHY23_RS06490	COG0583	DNA-binding transcription factor activity
CHY23_RS06500	COG0252	asparaginase activity
CHY23_RS06510	COG5413	integral membrane protein
CHY23_RS06525	COG3835	regulator
CHY23_RS06530	COG2610	gluconate transmembrane transporter activity
CHY23_RS06535	COG1929	Belongs to the glycerate kinase type-1 family
CHY23_RS06540	COG1254	Belongs to the acylphosphatase family
CHY23_RS06545	COG3593	DNA synthesis involved in DNA repair
CHY23_RS06550	COG1611	Belongs to the LOG family
CHY23_RS06555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHY23_RS06565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHY23_RS06570	COG0316	Belongs to the HesB IscA family
CHY23_RS06570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CHY23_RS06575	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHY23_RS06580	COG1805	sodium ion transport
CHY23_RS06585	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHY23_RS06590	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHY23_RS06595	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHY23_RS06600	COG2871	sodium ion transport
CHY23_RS06605	COG1477	protein flavinylation
CHY23_RS06610	COG2991	Protein conserved in bacteria
CHY23_RS06620	COG2814	Major facilitator Superfamily
CHY23_RS06625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CHY23_RS06635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHY23_RS06650	COG4657	Part of a membrane complex involved in electron transport
CHY23_RS06655	COG2878	Part of a membrane complex involved in electron transport
CHY23_RS06660	COG4656	Part of a membrane complex involved in electron transport
CHY23_RS06670	COG4658	electron transport chain
CHY23_RS06685	COG1560	Kdo2-lipid A biosynthetic process
CHY23_RS06690	COG0402	S-adenosylhomocysteine deaminase activity
CHY23_RS06695	COG4143	(ABC) transporter
CHY23_RS06700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CHY23_RS06705	COG0617	tRNA 3'-terminal CCA addition
CHY23_RS06710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CHY23_RS06720	COG2911	Protein conserved in bacteria
CHY23_RS06730	COG0346	lactoylglutathione lyase activity
CHY23_RS06735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHY23_RS06745	COG1605	Chorismate mutase
CHY23_RS06745	COG0287	Prephenate dehydrogenase
CHY23_RS06750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CHY23_RS06755	COG0859	PFAM glycosyl transferase family 9
CHY23_RS06760	COG0469	pyruvate kinase activity
CHY23_RS06765	COG2062	phosphohistidine phosphatase, SixA
CHY23_RS06770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHY23_RS06775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CHY23_RS06780	COG0733	neurotransmitter:sodium symporter activity
CHY23_RS06790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CHY23_RS06795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CHY23_RS06800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CHY23_RS06805	COG4972	Pilus assembly protein
CHY23_RS06825	COG4796	Type ii and iii secretion system protein
CHY23_RS06830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHY23_RS06835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CHY23_RS06840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CHY23_RS06845	COG1280	lysine exporter protein (LysE YggA)
CHY23_RS06850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHY23_RS06875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CHY23_RS06940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CHY23_RS06945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CHY23_RS06950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CHY23_RS06970	COG1253	flavin adenine dinucleotide binding
CHY23_RS06975	COG0564	pseudouridine synthase activity
CHY23_RS06980	COG0588	phosphoglycerate mutase activity
CHY23_RS06985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CHY23_RS06990	COG1678	Uncharacterized ACR, COG1678
CHY23_RS06995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CHY23_RS07005	COG0271	Belongs to the BolA IbaG family
CHY23_RS07030	COG0653	protein targeting
CHY23_RS07040	COG0494	nUDIX hydrolase
CHY23_RS07045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CHY23_RS07055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHY23_RS07070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CHY23_RS07075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CHY23_RS07080	COG0083	homoserine kinase activity
CHY23_RS07085	COG0460	homoserine dehydrogenase
CHY23_RS07085	COG0527	aspartate kinase activity
CHY23_RS07090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CHY23_RS07095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CHY23_RS07100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHY23_RS07130	COG2195	Cleaves the N-terminal amino acid of tripeptides
CHY23_RS07135	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CHY23_RS07140	COG0194	GDP metabolic process
CHY23_RS07145	COG1538	Outer membrane efflux protein
CHY23_RS07150	COG2914	Belongs to the UPF0125 (RnfH) family
CHY23_RS07155	COG2867	negative regulation of translational initiation
CHY23_RS07160	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CHY23_RS07165	COG4149	molybdate abc transporter
CHY23_RS07170	COG0725	ABC transporter, periplasmic molybdate-binding protein
CHY23_RS07175	COG0842	Transport permease protein
CHY23_RS07180	COG1131	(ABC) transporter
CHY23_RS07185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CHY23_RS07190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHY23_RS07200	COG0251	oxidation-reduction process
CHY23_RS07205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CHY23_RS07210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CHY23_RS07215	COG1121	(ABC) transporter
CHY23_RS07225	COG2920	part of a sulfur-relay system
CHY23_RS07230	COG0670	Belongs to the BI1 family
CHY23_RS07235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHY23_RS07245	COG0322	excinuclease ABC activity
CHY23_RS07250	COG0084	hydrolase, TatD family'
CHY23_RS07255	COG0210	DNA helicase
CHY23_RS07260	COG3842	ATPase activity
CHY23_RS07265	COG1176	ABC-type spermidine putrescine transport system, permease component I
CHY23_RS07270	COG1177	transmembrane transport
CHY23_RS07280	COG2255	four-way junction helicase activity
CHY23_RS07290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHY23_RS07320	COG0488	(ABC) transporter
CHY23_RS07325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CHY23_RS07335	COG1271	oxidase subunit
CHY23_RS07340	COG1294	oxidase, subunit
CHY23_RS07355	COG0824	Thioesterase
CHY23_RS07360	COG0811	peptide transport
CHY23_RS07365	COG0848	biopolymer transport protein
CHY23_RS07370	COG3064	Membrane
CHY23_RS07370	COG3064	Membrane
CHY23_RS07375	COG0823	Involved in the tonB-independent uptake of proteins
CHY23_RS07390	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CHY23_RS07395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHY23_RS07405	COG0488	(ABC) transporter
CHY23_RS07415	COG0303	'Molybdopterin
CHY23_RS07420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CHY23_RS07430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHY23_RS07435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CHY23_RS07445	COG0564	pseudouridine synthase activity
CHY23_RS07450	COG3023	N-Acetylmuramoyl-L-alanine amidase
CHY23_RS07455	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CHY23_RS07460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHY23_RS07465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CHY23_RS07470	COG0626	cystathionine gamma-synthase activity
CHY23_RS07475	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CHY23_RS07490	COG1702	phosphate starvation-inducible protein PhoH
CHY23_RS07555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CHY23_RS07575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CHY23_RS07580	COG1660	Displays ATPase and GTPase activities
CHY23_RS07585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHY23_RS07590	COG1137	ATPase activity
CHY23_RS07595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CHY23_RS07605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CHY23_RS07610	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CHY23_RS07620	COG1704	LemA family
CHY23_RS07630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHY23_RS07630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHY23_RS07630	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CHY23_RS07635	COG1105	Belongs to the carbohydrate kinase PfkB family
CHY23_RS07640	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHY23_RS07640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHY23_RS07650	COG1523	belongs to the glycosyl hydrolase 13 family
CHY23_RS07655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CHY23_RS07660	COG0297	glycogen (starch) synthase activity
CHY23_RS07665	COG0058	SHG alpha-glucan phosphorylase activity
CHY23_RS07680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHY23_RS07680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHY23_RS07695	COG1187	pseudouridine synthase activity
CHY23_RS07700	COG2814	Major facilitator Superfamily
CHY23_RS07710	COG3381	protein complex oligomerization
CHY23_RS07720	COG0791	NLP P60 protein
CHY23_RS07725	COG2932	Transcriptional regulator
CHY23_RS07730	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CHY23_RS07735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CHY23_RS07740	COG2990	Protein conserved in bacteria
CHY23_RS07750	COG1643	Atp-dependent helicase
CHY23_RS07755	COG2707	UPF0756 membrane protein
CHY23_RS07765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CHY23_RS07770	COG0534	Mate efflux family protein
CHY23_RS07775	COG1074	ATP-dependent DNA helicase activity
CHY23_RS07780	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CHY23_RS07785	COG4535	Mg2 and Co2 transporter CorC
CHY23_RS07795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CHY23_RS07800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CHY23_RS07805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CHY23_RS07810	COG2271	Major facilitator Superfamily
CHY23_RS07815	COG0584	glycerophosphoryl diester phosphodiesterase
CHY23_RS07820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CHY23_RS07825	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CHY23_RS07830	COG0247	lactate metabolic process
CHY23_RS07860	COG0517	IMP dehydrogenase activity
CHY23_RS07860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CHY23_RS07870	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CHY23_RS07875	COG0385	Bile acid
CHY23_RS07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHY23_RS07885	COG0561	phosphatase activity
CHY23_RS07895	COG1595	DNA-templated transcription, initiation
CHY23_RS07900	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CHY23_RS07910	COG0318	PFAM AMP-dependent synthetase and ligase
CHY23_RS07915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CHY23_RS07920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CHY23_RS07925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHY23_RS07930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CHY23_RS07950	COG1160	GTP binding
CHY23_RS07960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHY23_RS07975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHY23_RS07980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CHY23_RS07995	COG0750	zinc metalloprotease
CHY23_RS08000	COG0575	Belongs to the CDS family
CHY23_RS08005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CHY23_RS08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHY23_RS08020	COG0671	phosphoesterase, PA-phosphatase related
CHY23_RS08025	COG1534	Rna-binding protein
CHY23_RS08030	COG0463	Glycosyl transferase, family 2
CHY23_RS08035	COG1686	Belongs to the peptidase S11 family
CHY23_RS08040	COG0859	PFAM glycosyl transferase family 9
CHY23_RS08050	COG0328	RNA-DNA hybrid ribonuclease activity
CHY23_RS08055	COG1286	toxin biosynthetic process
CHY23_RS08060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CHY23_RS08070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CHY23_RS08075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CHY23_RS08085	COG0251	oxidation-reduction process
CHY23_RS08090	COG1496	oxidoreductase activity
CHY23_RS08100	COG5645	(Lipo)protein
CHY23_RS08115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CHY23_RS08125	COG1792	Involved in formation and maintenance of cell shape
CHY23_RS08130	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CHY23_RS08135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CHY23_RS08140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHY23_RS08145	COG0121	glutamine amidotransferase
CHY23_RS08150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHY23_RS08155	COG2949	membrane
CHY23_RS08170	COG1556	Lactate utilization protein
CHY23_RS08175	COG1139	Iron-sulfur cluster binding protein
CHY23_RS08180	COG0247	lactate metabolic process
CHY23_RS08185	COG1620	l-lactate permease
CHY23_RS08190	COG2916	Histone family protein nucleoid-structuring protein H-NS
CHY23_RS08195	COG1757	Na H antiporter
CHY23_RS08200	COG1879	ABC-type sugar transport system periplasmic component
CHY23_RS08205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CHY23_RS08215	COG2990	Protein conserved in bacteria
CHY23_RS08220	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHY23_RS08225	COG0567	Dehydrogenase, E1 component
CHY23_RS08230	COG1121	(ABC) transporter
CHY23_RS08235	COG0739	heme binding
CHY23_RS08240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHY23_RS08245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CHY23_RS08255	COG0561	phosphatase activity
CHY23_RS08260	COG3850	Histidine kinase
CHY23_RS08270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CHY23_RS08280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CHY23_RS08290	COG4221	oxidoreductase activity
CHY23_RS08295	COG0133	tryptophan synthase activity
CHY23_RS08315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHY23_RS08315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHY23_RS08320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CHY23_RS08330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHY23_RS08335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CHY23_RS08360	COG0640	Transcriptional regulator
CHY23_RS08370	COG0189	ligase activity
CHY23_RS08375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CHY23_RS08380	COG0281	malic enzyme
CHY23_RS08380	COG0280	phosphate acetyltransferase
CHY23_RS08385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CHY23_RS08480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHY23_RS08485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CHY23_RS08515	COG1403	HNH endonuclease
CHY23_RS08595	COG0740	serine-type endopeptidase activity
CHY23_RS08675	COG3683	transport system, periplasmic component
CHY23_RS08680	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CHY23_RS08685	COG1115	amino acid carrier protein
CHY23_RS08690	COG1116	anion transmembrane transporter activity
CHY23_RS08695	COG1116	anion transmembrane transporter activity
CHY23_RS08705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHY23_RS08710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CHY23_RS08715	COG2022	thiamine diphosphate biosynthetic process
CHY23_RS08720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CHY23_RS08725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CHY23_RS08730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CHY23_RS08745	COG0481	GTPase activity
CHY23_RS08750	COG0681	Belongs to the peptidase S26 family
CHY23_RS08755	COG0571	ribonuclease III activity
CHY23_RS08760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CHY23_RS08765	COG1381	Involved in DNA repair and RecF pathway recombination
CHY23_RS08850	COG0433	COG0433 Predicted ATPase
CHY23_RS08855	COG1840	ABC-type Fe3 transport system, periplasmic component
CHY23_RS08885	COG2194	sulfuric ester hydrolase activity
CHY23_RS08890	COG0528	UMP kinase activity
CHY23_RS08895	COG0233	cytoplasmic translational termination
CHY23_RS08900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHY23_RS08915	COG0590	tRNA wobble adenosine to inosine editing
CHY23_RS08920	COG0513	Belongs to the DEAD box helicase family
CHY23_RS08925	COG4785	May be involved in cell division
CHY23_RS08930	COG1185	polyribonucleotide nucleotidyltransferase activity
CHY23_RS08935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHY23_RS08950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CHY23_RS08965	COG3083	sulfuric ester hydrolase activity
CHY23_RS08970	COG3082	Protein of unknown function (DUF1414)
CHY23_RS08975	COG1309	transcriptional regulator
CHY23_RS08980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHY23_RS08985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHY23_RS09000	COG3955	Domain of unknown function (DUF1919)
CHY23_RS09005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHY23_RS09025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CHY23_RS09030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHY23_RS09035	COG0814	amino acid
CHY23_RS09040	COG0814	amino acid
CHY23_RS09050	COG3105	Protein conserved in bacteria
CHY23_RS09055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CHY23_RS09065	COG3022	response to hydroperoxide
CHY23_RS09080	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CHY23_RS09085	COG1823	symporter activity
CHY23_RS09090	COG0778	Nitroreductase
CHY23_RS09100	COG0072	phenylalanine-tRNA ligase activity
CHY23_RS09105	COG0776	regulation of translation
CHY23_RS09110	COG0791	NLP P60 protein
CHY23_RS09120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CHY23_RS09125	COG1940	carbohydrate kinase activity
CHY23_RS09125	COG1846	Transcriptional regulator
CHY23_RS09130	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CHY23_RS09135	COG1522	sequence-specific DNA binding
CHY23_RS09140	COG1674	ftsk spoiiie
CHY23_RS09145	COG2321	neutral zinc metallopeptidase
CHY23_RS09150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CHY23_RS09155	COG1214	PFAM Peptidase M22, glycoprotease
CHY23_RS09160	COG1435	thymidine kinase activity
CHY23_RS09165	COG3074	FtsZ-dependent cytokinesis
CHY23_RS09170	COG1494	fructose-1,6-bisphosphatase
CHY23_RS09175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CHY23_RS09180	COG0577	efflux transmembrane transporter activity
CHY23_RS09180	COG1136	(ABC) transporter
CHY23_RS09190	COG0745	RESPONSE REGULATOR receiver
CHY23_RS09195	COG3956	TIGRFAM MazG family protein
CHY23_RS09205	COG0285	dihydrofolate synthase activity
CHY23_RS09215	COG0779	Required for maturation of 30S ribosomal subunits
CHY23_RS09220	COG0195	Participates in both transcription termination and antitermination
CHY23_RS09225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CHY23_RS09230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CHY23_RS09235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CHY23_RS09240	COG2951	lytic endotransglycosylase activity
CHY23_RS09250	COG0280	phosphate acetyltransferase
CHY23_RS09250	COG0857	belongs to the CobB CobQ family
CHY23_RS09260	COG0737	Belongs to the 5'-nucleotidase family
CHY23_RS09280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CHY23_RS09290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CHY23_RS09300	COG0589	response to stress
CHY23_RS09310	COG2969	positive regulation of protein catabolic process
CHY23_RS09315	COG0625	glutathione transferase activity
CHY23_RS09320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CHY23_RS09330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CHY23_RS09335	COG1448	Aminotransferase
CHY23_RS09340	COG0006	proline dipeptidase activity
CHY23_RS09350	COG0556	nucleotide-excision repair
CHY23_RS09360	COG2822	iron ion transport
CHY23_RS09365	COG2837	iron assimilation
CHY23_RS09375	COG0613	PHP domain protein
CHY23_RS09385	COG2925	Exonuclease
CHY23_RS09395	COG0017	Asparaginyl-tRNA synthetase
CHY23_RS09400	COG1509	lysine 2,3-aminomutase activity
CHY23_RS09410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CHY23_RS09415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHY23_RS09420	COG2814	Major facilitator Superfamily
CHY23_RS09425	COG0741	lytic transglycosylase activity
CHY23_RS09430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CHY23_RS09435	COG0626	cystathionine gamma-synthase activity
CHY23_RS09440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CHY23_RS09445	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CHY23_RS09450	COG2363	Small membrane protein
CHY23_RS09455	COG0277	FAD linked oxidase domain protein
CHY23_RS09460	COG0243	molybdopterin cofactor binding
CHY23_RS09465	COG3005	denitrification pathway
CHY23_RS09475	COG0315	cyclic pyranopterin monophosphate synthase activity
CHY23_RS09480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CHY23_RS09485	COG0314	molybdopterin synthase activity
CHY23_RS09490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CHY23_RS09495	COG1444	tRNA N-acetyltransferase activity
CHY23_RS09505	COG0583	DNA-binding transcription factor activity
CHY23_RS09515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CHY23_RS09530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CHY23_RS09535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHY23_RS09550	COG1737	Transcriptional regulator
CHY23_RS09555	COG2731	YhcH YjgK YiaL family protein
CHY23_RS09560	COG0248	Ppx GppA phosphatase
CHY23_RS09570	COG0527	aspartate kinase activity
CHY23_RS09575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHY23_RS09580	COG3100	YcgL domain-containing protein
CHY23_RS09585	COG0305	Participates in initiation and elongation during chromosome replication
CHY23_RS09590	COG4607	ABC-type enterochelin transport system periplasmic component
CHY23_RS09595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHY23_RS09600	COG4605	iron ion homeostasis
CHY23_RS09605	COG4604	ABC transporter, ATP-binding protein
CHY23_RS09610	COG1392	Phosphate transport regulator
CHY23_RS09615	COG0306	phosphate transporter
CHY23_RS09620	COG4991	sh3 domain protein
CHY23_RS09630	COG3945	hemerythrin HHE cation binding domain
CHY23_RS09635	COG0343	queuine tRNA-ribosyltransferase activity
CHY23_RS09645	COG1278	Cold shock
CHY23_RS09650	COG0288	reversible hydration of carbon dioxide
CHY23_RS09655	COG0028	Belongs to the TPP enzyme family
CHY23_RS09660	COG0440	acetolactate synthase activity
CHY23_RS09665	COG0312	modulator of DNA gyrase
CHY23_RS09670	COG3028	Belongs to the UPF0307 family
CHY23_RS09675	COG3094	Invasion gene expression up-regulator, SirB
CHY23_RS09685	COG1811	Na channel or pump
CHY23_RS09690	COG3787	Belongs to the UPF0306 family
CHY23_RS09695	COG0023	Translation Initiation Factor
CHY23_RS09700	COG0284	orotidine-5'-phosphate decarboxylase activity
CHY23_RS09705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CHY23_RS09710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CHY23_RS09715	COG0776	regulation of translation
CHY23_RS09720	COG0539	negative regulation of cytoplasmic translation
CHY23_RS09730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHY23_RS09740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CHY23_RS09750	COG1785	Belongs to the alkaline phosphatase family
CHY23_RS09755	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CHY23_RS09765	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CHY23_RS09765	COG3264	Mechanosensitive ion channel
CHY23_RS09770	COG3264	Mechanosensitive ion channel
CHY23_RS09770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CHY23_RS09775	COG0318	PFAM AMP-dependent synthetase and ligase
CHY23_RS09780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CHY23_RS09785	COG0596	Alpha beta hydrolase
CHY23_RS09790	COG2226	methyltransferase
CHY23_RS09795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CHY23_RS09810	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CHY23_RS09815	COG1380	Effector of murein hydrolase LrgA
CHY23_RS09820	COG1346	cytolysis
CHY23_RS09825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CHY23_RS09835	COG3036	rescue of stalled ribosome
CHY23_RS09840	COG2226	methyltransferase
CHY23_RS09860	COG2333	competence protein COMEC
CHY23_RS09860	COG0658	competence protein
CHY23_RS09865	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CHY23_RS09875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CHY23_RS09880	COG0737	Belongs to the 5'-nucleotidase family
CHY23_RS09905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHY23_RS09910	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHY23_RS09915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CHY23_RS09920	COG0167	dihydroorotate dehydrogenase activity
CHY23_RS09925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CHY23_RS09940	COG1132	(ABC) transporter
CHY23_RS09945	COG1346	cytolysis
CHY23_RS09955	COG1199	ATP-dependent helicase activity
CHY23_RS09965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHY23_RS09970	COG0629	single-stranded DNA binding
CHY23_RS10000	COG2070	2-Nitropropane dioxygenase
CHY23_RS10010	COG2315	Protein conserved in bacteria
CHY23_RS10015	COG4172	Belongs to the ABC transporter superfamily
CHY23_RS10020	COG4171	peptide transport system, permease
CHY23_RS10025	COG4168	peptide transport system, permease
CHY23_RS10030	COG4166	transmembrane transport
CHY23_RS10035	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CHY23_RS10040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CHY23_RS10045	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CHY23_RS10050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CHY23_RS10070	COG1368	sulfuric ester hydrolase activity
CHY23_RS10075	COG3217	Mosc domain protein beta barrel domain protein
CHY23_RS10075	COG0633	Ferredoxin
CHY23_RS10080	COG1722	exodeoxyribonuclease VII activity
CHY23_RS10085	COG0142	geranyltranstransferase activity
CHY23_RS10095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CHY23_RS10100	COG1530	ribonuclease E activity
CHY23_RS10105	COG1944	ATP diphosphatase activity
CHY23_RS10120	COG0500	methyltransferase
CHY23_RS10130	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CHY23_RS10150	COG2351	hydroxyisourate hydrolase activity
CHY23_RS10160	COG0586	Pfam SNARE associated Golgi protein
CHY23_RS10165	COG0187	DNA topoisomerase II activity
CHY23_RS10175	COG1349	DNA-binding transcription factor activity
CHY23_RS10180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CHY23_RS10185	COG2915	High frequency lysogenization protein hflD homolog
CHY23_RS10190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CHY23_RS10195	COG4988	ABC transporter
CHY23_RS10200	COG2911	Protein conserved in bacteria
CHY23_RS10205	COG0729	surface antigen
CHY23_RS10210	COG2861	carbohydrate metabolic process
CHY23_RS10215	COG4942	peptidase
CHY23_RS10220	COG0588	phosphoglycerate mutase activity
CHY23_RS10230	COG0572	uridine kinase
CHY23_RS10235	COG0717	Belongs to the dCTP deaminase family
CHY23_RS10240	COG1309	transcriptional regulator
CHY23_RS10245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHY23_RS10250	COG0842	Transport permease protein
CHY23_RS10250	COG1129	ABC transporter
CHY23_RS10255	COG0842	Transport permease protein
CHY23_RS10265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CHY23_RS10270	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CHY23_RS10275	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CHY23_RS10285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CHY23_RS10290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CHY23_RS10295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHY23_RS10300	COG4166	transmembrane transport
CHY23_RS10310	COG0444	Belongs to the ABC transporter superfamily
CHY23_RS10315	COG4608	Belongs to the ABC transporter superfamily
CHY23_RS10325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CHY23_RS10335	COG0747	negative chemotaxis
CHY23_RS10340	COG0814	amino acid
CHY23_RS10345	COG1760	l-serine dehydratase
CHY23_RS10355	COG0135	phosphoribosylanthranilate isomerase activity
CHY23_RS10355	COG0134	indole-3-glycerol-phosphate synthase activity
CHY23_RS10360	COG3177	Filamentation induced by cAMP protein fic
CHY23_RS10365	COG3098	single-species biofilm formation
CHY23_RS10370	COG0564	pseudouridine synthase activity
CHY23_RS10375	COG3140	Belongs to the UPF0181 family
CHY23_RS10385	COG3025	triphosphatase activity
CHY23_RS10390	COG3106	COG3106 Predicted ATPase
CHY23_RS10395	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CHY23_RS10405	COG1473	amidohydrolase
CHY23_RS10410	COG3069	C4-dicarboxylate transmembrane transporter activity
CHY23_RS10420	COG0495	leucyl-tRNA aminoacylation
CHY23_RS10425	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CHY23_RS10430	COG1466	dna polymerase III delta subunit
CHY23_RS10435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CHY23_RS10440	COG0237	dephospho-CoA kinase activity
CHY23_RS10450	COG1459	type II secretion system
CHY23_RS10455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CHY23_RS10460	COG4969	Belongs to the N-Me-Phe pilin family
CHY23_RS10465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CHY23_RS10475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHY23_RS10480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CHY23_RS10485	COG0730	response to heat
CHY23_RS10490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CHY23_RS10500	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHY23_RS10500	COG1024	Enoyl-CoA hydratase
CHY23_RS10515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CHY23_RS10520	COG3383	formate dehydrogenase (NAD+) activity
CHY23_RS10520	COG0243	molybdopterin cofactor binding
CHY23_RS10525	COG0243	molybdopterin cofactor binding
CHY23_RS10525	COG3383	formate dehydrogenase (NAD+) activity
CHY23_RS10530	COG0437	4 iron, 4 sulfur cluster binding
CHY23_RS10535	COG2864	formate dehydrogenase
CHY23_RS10540	COG3058	Necessary for formate dehydrogenase activity
CHY23_RS10570	COG1560	Kdo2-lipid A biosynthetic process
CHY23_RS10575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CHY23_RS10585	COG0302	gtp cyclohydrolase
CHY23_RS10590	COG3642	lipopolysaccharide core region biosynthetic process
CHY23_RS10600	COG0110	maltose O-acetyltransferase activity
CHY23_RS10625	COG3423	Transcriptional regulator
CHY23_RS10630	COG2801	Transposase and inactivated derivatives
CHY23_RS10635	COG2842	Transposition protein
CHY23_RS10650	COG4396	Host-nuclease inhibitor protein Gam
CHY23_RS10680	COG4382	Mu-like prophage protein Gp16
CHY23_RS10690	COG5566	PFAM Mor transcription activator
CHY23_RS10695	COG3023	N-Acetylmuramoyl-L-alanine amidase
CHY23_RS10715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CHY23_RS10725	COG0640	Transcriptional regulator
CHY23_RS10735	COG4373	Mu-like prophage FluMu protein gp28
CHY23_RS10740	COG4383	Mu-like prophage protein gp29
CHY23_RS10745	COG2369	cell adhesion
CHY23_RS10750	COG5005	Phage virion morphogenesis
CHY23_RS10755	COG4388	Caudovirus prohead serine protease
CHY23_RS10760	COG4397	Mu-like prophage major head subunit gpT
CHY23_RS10770	COG4387	Mu-like prophage protein GP36
CHY23_RS10775	COG5003	unkown
CHY23_RS10835	COG3392	D12 class N6 adenine-specific DNA methyltransferase
CHY23_RS10845	COG0583	DNA-binding transcription factor activity
CHY23_RS10865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CHY23_RS10880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CHY23_RS10885	COG0617	tRNA 3'-terminal CCA addition
CHY23_RS10920	COG2975	iron-sulfur cluster assembly
CHY23_RS10925	COG0633	Ferredoxin
CHY23_RS10945	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CHY23_RS10955	COG0822	iron-sulfur transferase activity
CHY23_RS10960	COG1104	cysteine desulfurase activity
CHY23_RS10965	COG1959	2 iron, 2 sulfur cluster binding
CHY23_RS10975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CHY23_RS10980	COG5002	protein histidine kinase activity
CHY23_RS10980	COG0784	Response regulator, receiver
CHY23_RS10980	COG2198	Histidine kinase
CHY23_RS10985	COG0697	spore germination
CHY23_RS10990	COG2840	Smr protein MutS2
CHY23_RS10995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CHY23_RS11000	COG2226	methyltransferase
CHY23_RS11005	COG2830	Protein of unknown function (DUF452)
CHY23_RS11010	COG0156	8-amino-7-oxononanoate synthase activity
CHY23_RS11015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CHY23_RS11025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CHY23_RS11030	COG2027	D-alanyl-D-alanine carboxypeptidase
CHY23_RS11065	COG1444	tRNA N-acetyltransferase activity
CHY23_RS11070	COG0138	bifunctional purine biosynthesis protein purh
CHY23_RS11090	COG2831	hemolysin activation secretion protein
CHY23_RS11095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CHY23_RS11100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHY23_RS11115	COG2985	domain, Protein
CHY23_RS11115	COG0569	domain protein
CHY23_RS11120	COG0786	glutamate:sodium symporter activity
CHY23_RS11135	COG2350	Protein conserved in bacteria
CHY23_RS11140	COG1607	acyl-coa hydrolase
CHY23_RS11155	COG3092	negative regulation of chromosome organization
CHY23_RS11165	COG2056	Na+-H+ antiporter family
CHY23_RS11170	COG0708	Exodeoxyribonuclease III
CHY23_RS11175	COG0583	DNA-binding transcription factor activity
CHY23_RS11185	COG3306	glycosyltransferase involved in LPS biosynthesis
CHY23_RS11200	COG0254	rRNA binding
CHY23_RS11215	COG0753	catalase activity
CHY23_RS11225	COG1408	metallophosphoesterase
CHY23_RS11230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHY23_RS11235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHY23_RS11240	COG1085	galactose-1-phosphate uridylyltransferase
CHY23_RS11250	COG2017	converts alpha-aldose to the beta-anomer