locus-tag	class	description
APPSER1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APPSER1_RS00010	COG0592	DNA-directed DNA polymerase activity
APPSER1_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APPSER1_RS00040	COG0616	signal peptide processing
APPSER1_RS00055	COG3116	cell division
APPSER1_RS00060	COG0768	penicillin binding
APPSER1_RS00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APPSER1_RS00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APPSER1_RS00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APPSER1_RS00085	COG0772	Belongs to the SEDS family
APPSER1_RS00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APPSER1_RS00125	COG0497	DNA recombination
APPSER1_RS00130	COG4172	Belongs to the ABC transporter superfamily
APPSER1_RS00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APPSER1_RS00140	COG0601	transmembrane transport
APPSER1_RS00165	COG0193	aminoacyl-tRNA hydrolase activity
APPSER1_RS00170	COG0012	GTP binding
APPSER1_RS00175	COG2020	methyltransferase activity
APPSER1_RS00185	COG3133	Outer membrane lipoprotein
APPSER1_RS00190	COG3102	Protein conserved in bacteria
APPSER1_RS00195	COG0018	arginyl-trna synthetase
APPSER1_RS00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APPSER1_RS00215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APPSER1_RS00220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APPSER1_RS00225	COG0196	riboflavin kinase activity
APPSER1_RS00230	COG3172	ATPase kinase involved in NAD metabolism
APPSER1_RS00235	COG2129	metallophosphoesterase
APPSER1_RS00240	COG0745	RESPONSE REGULATOR receiver
APPSER1_RS00250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APPSER1_RS00255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APPSER1_RS00265	COG1217	gtp-binding protein TYPA
APPSER1_RS00270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APPSER1_RS00280	COG1561	YicC-like family, N-terminal region
APPSER1_RS00285	COG0354	folic acid binding
APPSER1_RS00290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APPSER1_RS00295	COG2197	response regulator
APPSER1_RS00305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APPSER1_RS00340	COG0747	negative chemotaxis
APPSER1_RS00345	COG0747	negative chemotaxis
APPSER1_RS00350	COG0601	transmembrane transport
APPSER1_RS00355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APPSER1_RS00360	COG0444	Belongs to the ABC transporter superfamily
APPSER1_RS00365	COG4608	Belongs to the ABC transporter superfamily
APPSER1_RS00380	COG0251	oxidation-reduction process
APPSER1_RS00385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APPSER1_RS00390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APPSER1_RS00395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APPSER1_RS00400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APPSER1_RS00405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APPSER1_RS00410	COG0848	biopolymer transport protein
APPSER1_RS00415	COG0811	peptide transport
APPSER1_RS00420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APPSER1_RS00425	COG3118	belongs to the thioredoxin family
APPSER1_RS00430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APPSER1_RS00430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPSER1_RS00430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APPSER1_RS00435	COG1461	Dihydroxyacetone kinase
APPSER1_RS00440	COG2376	Dihydroxyacetone kinase
APPSER1_RS00445	COG0492	ferredoxin-NADP+ reductase activity
APPSER1_RS00450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APPSER1_RS00455	COG3753	Protein conserved in bacteria
APPSER1_RS00475	COG3030	protein affecting phage T7 exclusion by the F plasmid
APPSER1_RS00480	COG0006	proline dipeptidase activity
APPSER1_RS00490	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
APPSER1_RS00510	COG0129	dihydroxy-acid dehydratase activity
APPSER1_RS00515	COG3978	acetolactate synthase activity
APPSER1_RS00530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APPSER1_RS00535	COG0437	4 iron, 4 sulfur cluster binding
APPSER1_RS00540	COG3301	Polysulphide reductase, NrfD
APPSER1_RS00550	COG5295	Hep Hag repeat protein
APPSER1_RS00550	COG5295	Hep Hag repeat protein
APPSER1_RS00565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APPSER1_RS00570	COG1414	Transcriptional regulator
APPSER1_RS00575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APPSER1_RS00585	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APPSER1_RS00595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APPSER1_RS00600	COG3068	Protein conserved in bacteria
APPSER1_RS00625	COG1278	Cold shock
APPSER1_RS00630	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
APPSER1_RS00635	COG0793	Belongs to the peptidase S41A family
APPSER1_RS00640	COG2989	Protein conserved in bacteria
APPSER1_RS00645	COG3108	Peptidase M15
APPSER1_RS00650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APPSER1_RS00665	COG0537	adenosine 5'-monophosphoramidase activity
APPSER1_RS00670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APPSER1_RS00675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APPSER1_RS00680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APPSER1_RS00685	COG1162	GTPase activity
APPSER1_RS00690	COG0583	DNA-binding transcription factor activity
APPSER1_RS00695	COG1011	Hydrolase
APPSER1_RS00700	COG0583	DNA-binding transcription factor activity
APPSER1_RS00710	COG0252	asparaginase activity
APPSER1_RS00720	COG5413	integral membrane protein
APPSER1_RS00735	COG3835	regulator
APPSER1_RS00740	COG2610	gluconate transmembrane transporter activity
APPSER1_RS00745	COG1929	Belongs to the glycerate kinase type-1 family
APPSER1_RS00750	COG1254	Belongs to the acylphosphatase family
APPSER1_RS00755	COG3593	DNA synthesis involved in DNA repair
APPSER1_RS00760	COG1611	Belongs to the LOG family
APPSER1_RS00765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APPSER1_RS00775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APPSER1_RS00780	COG0316	Belongs to the HesB IscA family
APPSER1_RS00780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APPSER1_RS00785	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APPSER1_RS00790	COG1805	sodium ion transport
APPSER1_RS00795	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APPSER1_RS00800	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APPSER1_RS00805	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APPSER1_RS00810	COG2871	sodium ion transport
APPSER1_RS00815	COG1477	protein flavinylation
APPSER1_RS00820	COG2991	Protein conserved in bacteria
APPSER1_RS00830	COG2814	Major facilitator Superfamily
APPSER1_RS00835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APPSER1_RS00845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APPSER1_RS00860	COG4657	Part of a membrane complex involved in electron transport
APPSER1_RS00865	COG2878	Part of a membrane complex involved in electron transport
APPSER1_RS00870	COG4656	Part of a membrane complex involved in electron transport
APPSER1_RS00880	COG4658	electron transport chain
APPSER1_RS00895	COG1560	Kdo2-lipid A biosynthetic process
APPSER1_RS00900	COG0402	S-adenosylhomocysteine deaminase activity
APPSER1_RS00905	COG4143	(ABC) transporter
APPSER1_RS00910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APPSER1_RS00915	COG0617	tRNA 3'-terminal CCA addition
APPSER1_RS00920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APPSER1_RS00930	COG2911	Protein conserved in bacteria
APPSER1_RS00940	COG0346	lactoylglutathione lyase activity
APPSER1_RS00945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APPSER1_RS00955	COG1605	Chorismate mutase
APPSER1_RS00955	COG0287	Prephenate dehydrogenase
APPSER1_RS00960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APPSER1_RS00965	COG0859	PFAM glycosyl transferase family 9
APPSER1_RS00970	COG0469	pyruvate kinase activity
APPSER1_RS00975	COG2062	phosphohistidine phosphatase, SixA
APPSER1_RS00980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APPSER1_RS00985	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APPSER1_RS00990	COG0733	neurotransmitter:sodium symporter activity
APPSER1_RS00995	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APPSER1_RS01000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APPSER1_RS01005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APPSER1_RS01010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APPSER1_RS01015	COG4972	Pilus assembly protein
APPSER1_RS01035	COG4796	Type ii and iii secretion system protein
APPSER1_RS01040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APPSER1_RS01045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APPSER1_RS01050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APPSER1_RS01055	COG1280	lysine exporter protein (LysE YggA)
APPSER1_RS01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APPSER1_RS01070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APPSER1_RS01085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APPSER1_RS01150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APPSER1_RS01155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APPSER1_RS01160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APPSER1_RS01180	COG1253	flavin adenine dinucleotide binding
APPSER1_RS01185	COG0564	pseudouridine synthase activity
APPSER1_RS01190	COG0588	phosphoglycerate mutase activity
APPSER1_RS01195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APPSER1_RS01200	COG1678	Uncharacterized ACR, COG1678
APPSER1_RS01205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APPSER1_RS01215	COG0271	Belongs to the BolA IbaG family
APPSER1_RS01240	COG0653	protein targeting
APPSER1_RS01250	COG0494	nUDIX hydrolase
APPSER1_RS01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APPSER1_RS01265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APPSER1_RS01275	COG1629	transport
APPSER1_RS01275	COG4771	TonB-dependent receptor
APPSER1_RS01280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APPSER1_RS01285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APPSER1_RS01290	COG0083	homoserine kinase activity
APPSER1_RS01295	COG0527	aspartate kinase activity
APPSER1_RS01295	COG0460	homoserine dehydrogenase
APPSER1_RS01300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APPSER1_RS01305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APPSER1_RS01310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APPSER1_RS01340	COG2195	Cleaves the N-terminal amino acid of tripeptides
APPSER1_RS01345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APPSER1_RS01350	COG0194	GDP metabolic process
APPSER1_RS01355	COG1538	Outer membrane efflux protein
APPSER1_RS01360	COG2914	Belongs to the UPF0125 (RnfH) family
APPSER1_RS01365	COG2867	negative regulation of translational initiation
APPSER1_RS01370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APPSER1_RS01375	COG4149	molybdate abc transporter
APPSER1_RS01380	COG0725	ABC transporter, periplasmic molybdate-binding protein
APPSER1_RS01385	COG0842	Transport permease protein
APPSER1_RS01390	COG1131	(ABC) transporter
APPSER1_RS01395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APPSER1_RS01400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APPSER1_RS01410	COG0251	oxidation-reduction process
APPSER1_RS01415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APPSER1_RS01420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APPSER1_RS01425	COG1121	(ABC) transporter
APPSER1_RS01435	COG2920	part of a sulfur-relay system
APPSER1_RS01440	COG0670	Belongs to the BI1 family
APPSER1_RS01445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APPSER1_RS01455	COG0322	excinuclease ABC activity
APPSER1_RS01460	COG0084	hydrolase, TatD family'
APPSER1_RS01465	COG0210	DNA helicase
APPSER1_RS01470	COG3842	ATPase activity
APPSER1_RS01475	COG1176	ABC-type spermidine putrescine transport system, permease component I
APPSER1_RS01480	COG1177	transmembrane transport
APPSER1_RS01490	COG2255	four-way junction helicase activity
APPSER1_RS01500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APPSER1_RS01530	COG0488	(ABC) transporter
APPSER1_RS01535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APPSER1_RS01545	COG1271	oxidase subunit
APPSER1_RS01550	COG1294	oxidase, subunit
APPSER1_RS01565	COG0824	Thioesterase
APPSER1_RS01570	COG0811	peptide transport
APPSER1_RS01575	COG0848	biopolymer transport protein
APPSER1_RS01580	COG3064	Membrane
APPSER1_RS01580	COG3064	Membrane
APPSER1_RS01585	COG0823	Involved in the tonB-independent uptake of proteins
APPSER1_RS01600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APPSER1_RS01605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APPSER1_RS01615	COG0488	(ABC) transporter
APPSER1_RS01625	COG0303	'Molybdopterin
APPSER1_RS01630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APPSER1_RS01640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APPSER1_RS01645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APPSER1_RS01655	COG0564	pseudouridine synthase activity
APPSER1_RS01660	COG3023	N-Acetylmuramoyl-L-alanine amidase
APPSER1_RS01665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APPSER1_RS01670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APPSER1_RS01675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APPSER1_RS01680	COG0626	cystathionine gamma-synthase activity
APPSER1_RS01685	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APPSER1_RS01700	COG1702	phosphate starvation-inducible protein PhoH
APPSER1_RS01765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APPSER1_RS01785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APPSER1_RS01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPSER1_RS01800	COG1137	ATPase activity
APPSER1_RS01805	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APPSER1_RS01815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APPSER1_RS01820	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APPSER1_RS01830	COG1704	LemA family
APPSER1_RS01840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APPSER1_RS01840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APPSER1_RS01840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APPSER1_RS01845	COG1105	Belongs to the carbohydrate kinase PfkB family
APPSER1_RS01850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPSER1_RS01850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPSER1_RS01860	COG1523	belongs to the glycosyl hydrolase 13 family
APPSER1_RS01865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APPSER1_RS01870	COG0297	glycogen (starch) synthase activity
APPSER1_RS01875	COG0058	SHG alpha-glucan phosphorylase activity
APPSER1_RS01890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APPSER1_RS01890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APPSER1_RS01905	COG1187	pseudouridine synthase activity
APPSER1_RS01910	COG2814	Major facilitator Superfamily
APPSER1_RS01920	COG3381	protein complex oligomerization
APPSER1_RS01930	COG0791	NLP P60 protein
APPSER1_RS01935	COG2932	Transcriptional regulator
APPSER1_RS01940	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
APPSER1_RS01945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APPSER1_RS01950	COG2990	Protein conserved in bacteria
APPSER1_RS01960	COG1643	Atp-dependent helicase
APPSER1_RS01965	COG2707	UPF0756 membrane protein
APPSER1_RS01975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APPSER1_RS01980	COG0534	Mate efflux family protein
APPSER1_RS01985	COG1074	ATP-dependent DNA helicase activity
APPSER1_RS01990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APPSER1_RS01995	COG4535	Mg2 and Co2 transporter CorC
APPSER1_RS02005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APPSER1_RS02010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APPSER1_RS02015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APPSER1_RS02020	COG2271	Major facilitator Superfamily
APPSER1_RS02025	COG0584	glycerophosphoryl diester phosphodiesterase
APPSER1_RS02030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APPSER1_RS02035	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
APPSER1_RS02040	COG0247	lactate metabolic process
APPSER1_RS02070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APPSER1_RS02070	COG0517	IMP dehydrogenase activity
APPSER1_RS02080	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APPSER1_RS02085	COG0385	Bile acid
APPSER1_RS02090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APPSER1_RS02095	COG0561	phosphatase activity
APPSER1_RS02105	COG1595	DNA-templated transcription, initiation
APPSER1_RS02110	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APPSER1_RS02120	COG0318	PFAM AMP-dependent synthetase and ligase
APPSER1_RS02125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APPSER1_RS02130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APPSER1_RS02135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APPSER1_RS02140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APPSER1_RS02160	COG1160	GTP binding
APPSER1_RS02170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APPSER1_RS02185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APPSER1_RS02190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APPSER1_RS02205	COG0750	zinc metalloprotease
APPSER1_RS02210	COG0575	Belongs to the CDS family
APPSER1_RS02215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APPSER1_RS02220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APPSER1_RS02230	COG0671	phosphoesterase, PA-phosphatase related
APPSER1_RS02235	COG1534	Rna-binding protein
APPSER1_RS02240	COG0463	Glycosyl transferase, family 2
APPSER1_RS02245	COG1686	Belongs to the peptidase S11 family
APPSER1_RS02250	COG0859	PFAM glycosyl transferase family 9
APPSER1_RS02260	COG0328	RNA-DNA hybrid ribonuclease activity
APPSER1_RS02265	COG1286	toxin biosynthetic process
APPSER1_RS02270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APPSER1_RS02280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APPSER1_RS02285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APPSER1_RS02295	COG0251	oxidation-reduction process
APPSER1_RS02300	COG1496	oxidoreductase activity
APPSER1_RS02310	COG5645	(Lipo)protein
APPSER1_RS02325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APPSER1_RS02335	COG1792	Involved in formation and maintenance of cell shape
APPSER1_RS02340	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APPSER1_RS02345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APPSER1_RS02350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APPSER1_RS02355	COG0121	glutamine amidotransferase
APPSER1_RS02360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APPSER1_RS02365	COG2949	membrane
APPSER1_RS02380	COG1556	Lactate utilization protein
APPSER1_RS02385	COG1139	Iron-sulfur cluster binding protein
APPSER1_RS02390	COG0247	lactate metabolic process
APPSER1_RS02395	COG1620	l-lactate permease
APPSER1_RS02400	COG2916	Histone family protein nucleoid-structuring protein H-NS
APPSER1_RS02405	COG1757	Na H antiporter
APPSER1_RS02410	COG1879	ABC-type sugar transport system periplasmic component
APPSER1_RS02415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APPSER1_RS02425	COG2990	Protein conserved in bacteria
APPSER1_RS02430	COG0508	dehydrogenase complex catalyzes the overall conversion of
APPSER1_RS02435	COG0567	Dehydrogenase, E1 component
APPSER1_RS02440	COG1121	(ABC) transporter
APPSER1_RS02445	COG0739	heme binding
APPSER1_RS02450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APPSER1_RS02455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APPSER1_RS02465	COG0561	phosphatase activity
APPSER1_RS02470	COG3850	Histidine kinase
APPSER1_RS02480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APPSER1_RS02490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APPSER1_RS02500	COG4221	oxidoreductase activity
APPSER1_RS02505	COG0133	tryptophan synthase activity
APPSER1_RS02525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APPSER1_RS02525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APPSER1_RS02530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APPSER1_RS02540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APPSER1_RS02545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APPSER1_RS02570	COG0640	Transcriptional regulator
APPSER1_RS02580	COG0189	ligase activity
APPSER1_RS02585	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APPSER1_RS02590	COG0280	phosphate acetyltransferase
APPSER1_RS02590	COG0281	malic enzyme
APPSER1_RS02595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APPSER1_RS02695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APPSER1_RS02700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APPSER1_RS02730	COG1403	HNH endonuclease
APPSER1_RS02810	COG0740	serine-type endopeptidase activity
APPSER1_RS02890	COG3683	transport system, periplasmic component
APPSER1_RS02895	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APPSER1_RS02900	COG1115	amino acid carrier protein
APPSER1_RS02905	COG1116	anion transmembrane transporter activity
APPSER1_RS02910	COG1116	anion transmembrane transporter activity
APPSER1_RS02920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APPSER1_RS02925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APPSER1_RS02930	COG2022	thiamine diphosphate biosynthetic process
APPSER1_RS02935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APPSER1_RS02940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APPSER1_RS02945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APPSER1_RS02960	COG0481	GTPase activity
APPSER1_RS02965	COG0681	Belongs to the peptidase S26 family
APPSER1_RS02970	COG0571	ribonuclease III activity
APPSER1_RS02975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APPSER1_RS02980	COG1381	Involved in DNA repair and RecF pathway recombination
APPSER1_RS03065	COG0433	COG0433 Predicted ATPase
APPSER1_RS03070	COG1840	ABC-type Fe3 transport system, periplasmic component
APPSER1_RS03100	COG2194	sulfuric ester hydrolase activity
APPSER1_RS03105	COG0528	UMP kinase activity
APPSER1_RS03110	COG0233	cytoplasmic translational termination
APPSER1_RS03115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APPSER1_RS03130	COG0590	tRNA wobble adenosine to inosine editing
APPSER1_RS03135	COG0513	Belongs to the DEAD box helicase family
APPSER1_RS03140	COG4785	May be involved in cell division
APPSER1_RS03145	COG1185	polyribonucleotide nucleotidyltransferase activity
APPSER1_RS03150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APPSER1_RS03165	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APPSER1_RS03180	COG3083	sulfuric ester hydrolase activity
APPSER1_RS03185	COG3082	Protein of unknown function (DUF1414)
APPSER1_RS03190	COG1309	transcriptional regulator
APPSER1_RS03195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APPSER1_RS03200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APPSER1_RS03215	COG3955	Domain of unknown function (DUF1919)
APPSER1_RS03220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APPSER1_RS03235	COG0517	IMP dehydrogenase activity
APPSER1_RS03235	COG0516	GMP reductase activity
APPSER1_RS03240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APPSER1_RS03245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APPSER1_RS03250	COG0814	amino acid
APPSER1_RS03255	COG0814	amino acid
APPSER1_RS03265	COG3105	Protein conserved in bacteria
APPSER1_RS03270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APPSER1_RS03280	COG3022	response to hydroperoxide
APPSER1_RS03295	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
APPSER1_RS03300	COG1823	symporter activity
APPSER1_RS03305	COG0778	Nitroreductase
APPSER1_RS03310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APPSER1_RS03315	COG0072	phenylalanine-tRNA ligase activity
APPSER1_RS03320	COG0776	regulation of translation
APPSER1_RS03325	COG0791	NLP P60 protein
APPSER1_RS03335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APPSER1_RS03340	COG1846	Transcriptional regulator
APPSER1_RS03340	COG1940	carbohydrate kinase activity
APPSER1_RS03345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APPSER1_RS03350	COG1522	sequence-specific DNA binding
APPSER1_RS03355	COG1674	ftsk spoiiie
APPSER1_RS03360	COG2321	neutral zinc metallopeptidase
APPSER1_RS03365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APPSER1_RS03370	COG1214	PFAM Peptidase M22, glycoprotease
APPSER1_RS03375	COG1435	thymidine kinase activity
APPSER1_RS03380	COG3074	FtsZ-dependent cytokinesis
APPSER1_RS03385	COG1494	fructose-1,6-bisphosphatase
APPSER1_RS03390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APPSER1_RS03395	COG1136	(ABC) transporter
APPSER1_RS03395	COG0577	efflux transmembrane transporter activity
APPSER1_RS03400	COG2205	protein histidine kinase activity
APPSER1_RS03405	COG0745	RESPONSE REGULATOR receiver
APPSER1_RS03410	COG3956	TIGRFAM MazG family protein
APPSER1_RS03420	COG0285	dihydrofolate synthase activity
APPSER1_RS03430	COG0779	Required for maturation of 30S ribosomal subunits
APPSER1_RS03435	COG0195	Participates in both transcription termination and antitermination
APPSER1_RS03440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APPSER1_RS03445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APPSER1_RS03450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APPSER1_RS03455	COG2951	lytic endotransglycosylase activity
APPSER1_RS03465	COG0857	belongs to the CobB CobQ family
APPSER1_RS03465	COG0280	phosphate acetyltransferase
APPSER1_RS03475	COG0737	Belongs to the 5'-nucleotidase family
APPSER1_RS03495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APPSER1_RS03505	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APPSER1_RS03515	COG0589	response to stress
APPSER1_RS03525	COG2969	positive regulation of protein catabolic process
APPSER1_RS03530	COG0625	glutathione transferase activity
APPSER1_RS03535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APPSER1_RS03545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APPSER1_RS03550	COG1448	Aminotransferase
APPSER1_RS03555	COG0006	proline dipeptidase activity
APPSER1_RS03565	COG0556	nucleotide-excision repair
APPSER1_RS03570	COG2822	iron ion transport
APPSER1_RS03575	COG2837	iron assimilation
APPSER1_RS03585	COG0613	PHP domain protein
APPSER1_RS03595	COG2925	Exonuclease
APPSER1_RS03600	COG0038	chloride channel
APPSER1_RS03605	COG0017	Asparaginyl-tRNA synthetase
APPSER1_RS03610	COG1509	lysine 2,3-aminomutase activity
APPSER1_RS03620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APPSER1_RS03625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APPSER1_RS03635	COG0741	lytic transglycosylase activity
APPSER1_RS03640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APPSER1_RS03645	COG0626	cystathionine gamma-synthase activity
APPSER1_RS03650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APPSER1_RS03655	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
APPSER1_RS03660	COG2363	Small membrane protein
APPSER1_RS03665	COG0277	FAD linked oxidase domain protein
APPSER1_RS03670	COG0243	molybdopterin cofactor binding
APPSER1_RS03675	COG3005	denitrification pathway
APPSER1_RS03685	COG0315	cyclic pyranopterin monophosphate synthase activity
APPSER1_RS03690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APPSER1_RS03695	COG0314	molybdopterin synthase activity
APPSER1_RS03700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APPSER1_RS03705	COG1444	tRNA N-acetyltransferase activity
APPSER1_RS03715	COG0583	DNA-binding transcription factor activity
APPSER1_RS03725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APPSER1_RS03740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APPSER1_RS03745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APPSER1_RS03765	COG1737	Transcriptional regulator
APPSER1_RS03770	COG2731	YhcH YjgK YiaL family protein
APPSER1_RS03775	COG0248	Ppx GppA phosphatase
APPSER1_RS03785	COG0527	aspartate kinase activity
APPSER1_RS03790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APPSER1_RS03795	COG3100	YcgL domain-containing protein
APPSER1_RS03800	COG0305	Participates in initiation and elongation during chromosome replication
APPSER1_RS03805	COG4607	ABC-type enterochelin transport system periplasmic component
APPSER1_RS03810	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APPSER1_RS03815	COG4605	iron ion homeostasis
APPSER1_RS03820	COG4604	ABC transporter, ATP-binding protein
APPSER1_RS03825	COG1392	Phosphate transport regulator
APPSER1_RS03830	COG0306	phosphate transporter
APPSER1_RS03835	COG4991	sh3 domain protein
APPSER1_RS03845	COG3945	hemerythrin HHE cation binding domain
APPSER1_RS03850	COG0343	queuine tRNA-ribosyltransferase activity
APPSER1_RS03860	COG1278	Cold shock
APPSER1_RS03865	COG0288	reversible hydration of carbon dioxide
APPSER1_RS03870	COG0028	Belongs to the TPP enzyme family
APPSER1_RS03875	COG0440	acetolactate synthase activity
APPSER1_RS03880	COG0312	modulator of DNA gyrase
APPSER1_RS03885	COG3028	Belongs to the UPF0307 family
APPSER1_RS03890	COG3094	Invasion gene expression up-regulator, SirB
APPSER1_RS03900	COG1811	Na channel or pump
APPSER1_RS03905	COG3787	Belongs to the UPF0306 family
APPSER1_RS03910	COG0023	Translation Initiation Factor
APPSER1_RS03915	COG0284	orotidine-5'-phosphate decarboxylase activity
APPSER1_RS03920	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APPSER1_RS03925	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APPSER1_RS03930	COG0776	regulation of translation
APPSER1_RS03935	COG0539	negative regulation of cytoplasmic translation
APPSER1_RS03945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APPSER1_RS03955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APPSER1_RS03965	COG1785	Belongs to the alkaline phosphatase family
APPSER1_RS03970	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
APPSER1_RS03980	COG3264	Mechanosensitive ion channel
APPSER1_RS03980	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APPSER1_RS03985	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APPSER1_RS03985	COG3264	Mechanosensitive ion channel
APPSER1_RS03990	COG0318	PFAM AMP-dependent synthetase and ligase
APPSER1_RS03995	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APPSER1_RS04000	COG0596	Alpha beta hydrolase
APPSER1_RS04005	COG2226	methyltransferase
APPSER1_RS04010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APPSER1_RS04025	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
APPSER1_RS04030	COG1380	Effector of murein hydrolase LrgA
APPSER1_RS04035	COG1346	cytolysis
APPSER1_RS04040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APPSER1_RS04050	COG3036	rescue of stalled ribosome
APPSER1_RS04055	COG2226	methyltransferase
APPSER1_RS04075	COG2333	competence protein COMEC
APPSER1_RS04075	COG0658	competence protein
APPSER1_RS04080	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APPSER1_RS04090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APPSER1_RS04095	COG0737	Belongs to the 5'-nucleotidase family
APPSER1_RS04120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APPSER1_RS04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
APPSER1_RS04130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APPSER1_RS04135	COG0167	dihydroorotate dehydrogenase activity
APPSER1_RS04140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APPSER1_RS04155	COG1132	(ABC) transporter
APPSER1_RS04160	COG1346	cytolysis
APPSER1_RS04170	COG1199	ATP-dependent helicase activity
APPSER1_RS04180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APPSER1_RS04185	COG0629	single-stranded DNA binding
APPSER1_RS04215	COG2070	2-Nitropropane dioxygenase
APPSER1_RS04225	COG2315	Protein conserved in bacteria
APPSER1_RS04230	COG4172	Belongs to the ABC transporter superfamily
APPSER1_RS04235	COG4171	peptide transport system, permease
APPSER1_RS04240	COG4168	peptide transport system, permease
APPSER1_RS04245	COG4166	transmembrane transport
APPSER1_RS04250	COG3283	Transcriptional regulator of aromatic amino acids metabolism
APPSER1_RS04255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APPSER1_RS04260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APPSER1_RS04265	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APPSER1_RS04285	COG1368	sulfuric ester hydrolase activity
APPSER1_RS04290	COG0633	Ferredoxin
APPSER1_RS04290	COG3217	Mosc domain protein beta barrel domain protein
APPSER1_RS04295	COG1722	exodeoxyribonuclease VII activity
APPSER1_RS04300	COG0142	geranyltranstransferase activity
APPSER1_RS04310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APPSER1_RS04315	COG1530	ribonuclease E activity
APPSER1_RS04320	COG1944	ATP diphosphatase activity
APPSER1_RS04335	COG0500	methyltransferase
APPSER1_RS04345	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APPSER1_RS04365	COG2351	hydroxyisourate hydrolase activity
APPSER1_RS04375	COG0586	Pfam SNARE associated Golgi protein
APPSER1_RS04380	COG0187	DNA topoisomerase II activity
APPSER1_RS04390	COG1349	DNA-binding transcription factor activity
APPSER1_RS04395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APPSER1_RS04400	COG2915	High frequency lysogenization protein hflD homolog
APPSER1_RS04405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APPSER1_RS04410	COG4988	ABC transporter
APPSER1_RS04415	COG2911	Protein conserved in bacteria
APPSER1_RS04420	COG0729	surface antigen
APPSER1_RS04425	COG2861	carbohydrate metabolic process
APPSER1_RS04430	COG4942	peptidase
APPSER1_RS04435	COG0588	phosphoglycerate mutase activity
APPSER1_RS04445	COG0572	uridine kinase
APPSER1_RS04450	COG0717	Belongs to the dCTP deaminase family
APPSER1_RS04455	COG1309	transcriptional regulator
APPSER1_RS04460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APPSER1_RS04465	COG1129	ABC transporter
APPSER1_RS04465	COG0842	Transport permease protein
APPSER1_RS04470	COG0842	Transport permease protein
APPSER1_RS04480	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APPSER1_RS04485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APPSER1_RS04490	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APPSER1_RS04500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APPSER1_RS04505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APPSER1_RS04510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APPSER1_RS04515	COG4166	transmembrane transport
APPSER1_RS04525	COG0444	Belongs to the ABC transporter superfamily
APPSER1_RS04530	COG4608	Belongs to the ABC transporter superfamily
APPSER1_RS04540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APPSER1_RS04550	COG0747	negative chemotaxis
APPSER1_RS04555	COG0814	amino acid
APPSER1_RS04560	COG1760	l-serine dehydratase
APPSER1_RS04570	COG0134	indole-3-glycerol-phosphate synthase activity
APPSER1_RS04570	COG0135	phosphoribosylanthranilate isomerase activity
APPSER1_RS04575	COG3177	Filamentation induced by cAMP protein fic
APPSER1_RS04580	COG3098	single-species biofilm formation
APPSER1_RS04585	COG0564	pseudouridine synthase activity
APPSER1_RS04590	COG3140	Belongs to the UPF0181 family
APPSER1_RS04600	COG3025	triphosphatase activity
APPSER1_RS04605	COG3106	COG3106 Predicted ATPase
APPSER1_RS04610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APPSER1_RS04620	COG1473	amidohydrolase
APPSER1_RS04625	COG3069	C4-dicarboxylate transmembrane transporter activity
APPSER1_RS04635	COG0495	leucyl-tRNA aminoacylation
APPSER1_RS04640	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
APPSER1_RS04645	COG1466	dna polymerase III delta subunit
APPSER1_RS04650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APPSER1_RS04655	COG0237	dephospho-CoA kinase activity
APPSER1_RS04665	COG1459	type II secretion system
APPSER1_RS04670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APPSER1_RS04675	COG4969	Belongs to the N-Me-Phe pilin family
APPSER1_RS04680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APPSER1_RS04690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APPSER1_RS04695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APPSER1_RS04700	COG0730	response to heat
APPSER1_RS04705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APPSER1_RS04715	COG1250	3-hydroxyacyl-CoA dehydrogenase
APPSER1_RS04715	COG1024	Enoyl-CoA hydratase
APPSER1_RS04730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APPSER1_RS04735	COG0243	molybdopterin cofactor binding
APPSER1_RS04735	COG3383	formate dehydrogenase (NAD+) activity
APPSER1_RS04740	COG3383	formate dehydrogenase (NAD+) activity
APPSER1_RS04740	COG0243	molybdopterin cofactor binding
APPSER1_RS04745	COG0437	4 iron, 4 sulfur cluster binding
APPSER1_RS04750	COG2864	formate dehydrogenase
APPSER1_RS04755	COG3058	Necessary for formate dehydrogenase activity
APPSER1_RS04785	COG1560	Kdo2-lipid A biosynthetic process
APPSER1_RS04790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APPSER1_RS04800	COG0302	gtp cyclohydrolase
APPSER1_RS04805	COG3642	lipopolysaccharide core region biosynthetic process
APPSER1_RS04815	COG0110	maltose O-acetyltransferase activity
APPSER1_RS04830	COG4382	Mu-like prophage protein Gp16
APPSER1_RS04850	COG4396	Host-nuclease inhibitor protein Gam
APPSER1_RS04860	COG3267	Type II secretory pathway component ExeA
APPSER1_RS04860	COG3409	Peptidoglycan-binding domain 1 protein
APPSER1_RS04945	COG4373	Mu-like prophage FluMu protein gp28
APPSER1_RS05050	COG3392	D12 class N6 adenine-specific DNA methyltransferase
APPSER1_RS05060	COG0583	DNA-binding transcription factor activity
APPSER1_RS05080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APPSER1_RS05095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APPSER1_RS05100	COG0617	tRNA 3'-terminal CCA addition
APPSER1_RS05135	COG2975	iron-sulfur cluster assembly
APPSER1_RS05140	COG0633	Ferredoxin
APPSER1_RS05160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APPSER1_RS05170	COG0822	iron-sulfur transferase activity
APPSER1_RS05175	COG1104	cysteine desulfurase activity
APPSER1_RS05180	COG1959	2 iron, 2 sulfur cluster binding
APPSER1_RS05190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APPSER1_RS05195	COG0784	Response regulator, receiver
APPSER1_RS05195	COG2198	Histidine kinase
APPSER1_RS05195	COG5002	protein histidine kinase activity
APPSER1_RS05200	COG0697	spore germination
APPSER1_RS05205	COG2840	Smr protein MutS2
APPSER1_RS05210	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APPSER1_RS05215	COG2226	methyltransferase
APPSER1_RS05220	COG2830	Protein of unknown function (DUF452)
APPSER1_RS05225	COG0156	8-amino-7-oxononanoate synthase activity
APPSER1_RS05230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APPSER1_RS05240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APPSER1_RS05245	COG2027	D-alanyl-D-alanine carboxypeptidase
APPSER1_RS05280	COG1444	tRNA N-acetyltransferase activity
APPSER1_RS05285	COG0138	bifunctional purine biosynthesis protein purh
APPSER1_RS05295	COG3210	domain, Protein
APPSER1_RS05315	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APPSER1_RS05320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APPSER1_RS05335	COG2985	domain, Protein
APPSER1_RS05335	COG0569	domain protein
APPSER1_RS05340	COG0786	glutamate:sodium symporter activity
APPSER1_RS05355	COG2350	Protein conserved in bacteria
APPSER1_RS05360	COG1607	acyl-coa hydrolase
APPSER1_RS05375	COG3092	negative regulation of chromosome organization
APPSER1_RS05385	COG2056	Na+-H+ antiporter family
APPSER1_RS05390	COG0708	Exodeoxyribonuclease III
APPSER1_RS05395	COG0583	DNA-binding transcription factor activity
APPSER1_RS05405	COG3306	glycosyltransferase involved in LPS biosynthesis
APPSER1_RS05420	COG0254	rRNA binding
APPSER1_RS05435	COG0753	catalase activity
APPSER1_RS05445	COG1408	metallophosphoesterase
APPSER1_RS05450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APPSER1_RS05455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APPSER1_RS05460	COG1085	galactose-1-phosphate uridylyltransferase
APPSER1_RS05470	COG2017	converts alpha-aldose to the beta-anomer
APPSER1_RS05490	COG0489	protein tyrosine kinase activity
APPSER1_RS05500	COG2095	MarC family integral membrane protein
APPSER1_RS05505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APPSER1_RS05515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APPSER1_RS05520	COG2354	Protein conserved in bacteria
APPSER1_RS05525	COG3071	HemY protein
APPSER1_RS05530	COG2959	enzyme of heme biosynthesis
APPSER1_RS05540	COG0181	hydroxymethylbilane synthase activity
APPSER1_RS05545	COG1454	alcohol dehydrogenase
APPSER1_RS05545	COG1012	belongs to the aldehyde dehydrogenase family
APPSER1_RS05560	COG0813	purine-nucleoside phosphorylase activity
APPSER1_RS05565	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APPSER1_RS05570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APPSER1_RS05575	COG2364	Membrane
APPSER1_RS05580	COG0800	Aldolase
APPSER1_RS05585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APPSER1_RS05590	COG1904	glucuronate isomerase
APPSER1_RS05600	COG2186	Transcriptional regulator
APPSER1_RS05610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APPSER1_RS05610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APPSER1_RS05615	COG1216	Glycosyl transferase, family 2
APPSER1_RS05620	COG1216	Glycosyl transferase, family 2
APPSER1_RS05630	COG3306	glycosyltransferase involved in LPS biosynthesis
APPSER1_RS05640	COG5039	Polysaccharide pyruvyl transferase
APPSER1_RS05645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APPSER1_RS05650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APPSER1_RS05655	COG0077	Prephenate dehydratase
APPSER1_RS05655	COG1605	Chorismate mutase
APPSER1_RS05660	COG0339	signal peptide processing
APPSER1_RS05665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APPSER1_RS05670	COG1882	Formate acetyltransferase
APPSER1_RS05675	COG2116	formate transmembrane transporter activity
APPSER1_RS05680	COG1238	metal cluster binding
APPSER1_RS05685	COG0501	Belongs to the peptidase M48B family
APPSER1_RS05695	COG2431	L-lysine efflux transmembrane transporter activity
APPSER1_RS05700	COG1169	isochorismate synthase
APPSER1_RS05705	COG0436	Aminotransferase
APPSER1_RS05715	COG2962	Rard protein
APPSER1_RS05725	COG4771	TonB-dependent receptor
APPSER1_RS05725	COG1629	transport
APPSER1_RS05730	COG0748	coenzyme F420 binding
APPSER1_RS05740	COG3088	subunit of a heme lyase
APPSER1_RS05740	COG4235	cytochrome complex assembly
APPSER1_RS05745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APPSER1_RS05750	COG1138	Cytochrome C-type biogenesis protein
APPSER1_RS05755	COG0475	glutathione-regulated potassium exporter activity
APPSER1_RS05755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APPSER1_RS05765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APPSER1_RS05780	COG3111	PFAM Bacterial OB fold (BOF) protein
APPSER1_RS05795	COG0745	RESPONSE REGULATOR receiver
APPSER1_RS05800	COG0642	Histidine kinase
APPSER1_RS05805	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APPSER1_RS05810	COG1862	Preprotein translocase
APPSER1_RS05815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APPSER1_RS05820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APPSER1_RS05825	COG1528	Iron-storage protein
APPSER1_RS05830	COG1528	Iron-storage protein
APPSER1_RS05835	COG2252	PERMEase
APPSER1_RS05840	COG0424	maF-like protein
APPSER1_RS05855	COG0583	DNA-binding transcription factor activity
APPSER1_RS05870	COG1373	ATPase (AAA superfamily
APPSER1_RS05885	COG1902	pentaerythritol trinitrate reductase activity
APPSER1_RS05890	COG0301	tRNA thio-modification
APPSER1_RS05890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APPSER1_RS05895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APPSER1_RS05905	COG0330	HflC and HflK could
APPSER1_RS05910	COG0330	HflC and HflK could
APPSER1_RS05915	COG3118	belongs to the thioredoxin family
APPSER1_RS05935	COG0531	amino acid
APPSER1_RS05940	COG0531	amino acid
APPSER1_RS05955	COG3047	cAMP biosynthetic process
APPSER1_RS05960	COG0542	response to heat
APPSER1_RS05965	COG0798	PFAM Bile acid sodium symporter
APPSER1_RS05970	COG1393	Belongs to the ArsC family
APPSER1_RS05980	COG1027	Aspartate ammonia-lyase
APPSER1_RS05990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APPSER1_RS05995	COG3064	Membrane
APPSER1_RS05995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APPSER1_RS05995	COG3583	domain protein
APPSER1_RS06005	COG0720	synthase
APPSER1_RS06010	COG0602	queuosine metabolic process
APPSER1_RS06035	COG0795	lipopolysaccharide-transporting ATPase activity
APPSER1_RS06040	COG0795	lipopolysaccharide-transporting ATPase activity
APPSER1_RS06050	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APPSER1_RS06055	COG2937	Belongs to the GPAT DAPAT family
APPSER1_RS06060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APPSER1_RS06065	COG3066	DNA modification
APPSER1_RS06070	COG0861	Integral membrane protein TerC family
APPSER1_RS06075	COG1472	Belongs to the glycosyl hydrolase 3 family
APPSER1_RS06080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APPSER1_RS06085	COG0148	phosphopyruvate hydratase activity
APPSER1_RS06090	COG1051	belongs to the nudix hydrolase family
APPSER1_RS06095	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
APPSER1_RS06105	COG1965	Belongs to the frataxin family
APPSER1_RS06120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APPSER1_RS06125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APPSER1_RS06130	COG0564	pseudouridine synthase activity
APPSER1_RS06140	COG0205	6-phosphofructokinase activity
APPSER1_RS06145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APPSER1_RS06150	COG1525	nuclease
APPSER1_RS06155	COG1115	amino acid carrier protein
APPSER1_RS06160	COG0628	permease
APPSER1_RS06170	COG0826	peptidase U32
APPSER1_RS06175	COG3307	-O-antigen
APPSER1_RS06180	COG1519	Transferase
APPSER1_RS06190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APPSER1_RS06195	COG0802	atpase or kinase
APPSER1_RS06200	COG0860	N-Acetylmuramoyl-L-alanine amidase
APPSER1_RS06200	COG1388	LysM domain
APPSER1_RS06205	COG0166	Belongs to the GPI family
APPSER1_RS06210	COG2960	long-chain fatty acid transporting porin activity
APPSER1_RS06230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APPSER1_RS06240	COG0551	DNA topoisomerase type I activity
APPSER1_RS06250	COG2137	regulation of response to DNA damage stimulus
APPSER1_RS06255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APPSER1_RS06260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APPSER1_RS06270	COG1322	Protein conserved in bacteria
APPSER1_RS06275	COG0512	Glutamine amidotransferase of anthranilate synthase
APPSER1_RS06285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APPSER1_RS06290	COG0494	nUDIX hydrolase
APPSER1_RS06305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APPSER1_RS06310	COG0612	Peptidase, M16
APPSER1_RS06320	COG0471	metal ion transport
APPSER1_RS06325	COG0583	DNA-binding transcription factor activity
APPSER1_RS06330	COG3266	domain, Protein
APPSER1_RS06335	COG1187	pseudouridine synthase activity
APPSER1_RS06340	COG0009	L-threonylcarbamoyladenylate synthase
APPSER1_RS06350	COG2837	iron assimilation
APPSER1_RS06355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APPSER1_RS06360	COG0512	Glutamine amidotransferase of anthranilate synthase
APPSER1_RS06370	COG2226	methyltransferase
APPSER1_RS06375	COG2268	Band 7 protein
APPSER1_RS06380	COG2841	Protein conserved in bacteria
APPSER1_RS06395	COG2965	DNA replication, synthesis of RNA primer
APPSER1_RS06410	COG3201	nicotinamide mononucleotide transporter
APPSER1_RS06415	COG2976	Protein conserved in bacteria
APPSER1_RS06425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APPSER1_RS06430	COG1426	Protein conserved in bacteria
APPSER1_RS06435	COG0659	secondary active sulfate transmembrane transporter activity
APPSER1_RS06445	COG0673	inositol 2-dehydrogenase activity
APPSER1_RS06450	COG0475	glutathione-regulated potassium exporter activity
APPSER1_RS06450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APPSER1_RS06495	COG1764	response to oxidative stress
APPSER1_RS06525	COG2207	Transcriptional regulator
APPSER1_RS06535	COG1902	pentaerythritol trinitrate reductase activity
APPSER1_RS06540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APPSER1_RS06545	COG2084	Dehydrogenase
APPSER1_RS06550	COG0778	Nitroreductase
APPSER1_RS06555	COG2095	MarC family integral membrane protein
APPSER1_RS06570	COG0625	glutathione transferase activity
APPSER1_RS06585	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APPSER1_RS06590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APPSER1_RS06605	COG1275	C4-dicarboxylate transporter malic acid transport protein
APPSER1_RS06610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APPSER1_RS06625	COG1132	(ABC) transporter
APPSER1_RS06630	COG1854	S-ribosylhomocysteine lyase activity
APPSER1_RS06635	COG3008	intermembrane lipid transfer
APPSER1_RS06640	COG0735	belongs to the Fur family
APPSER1_RS06645	COG0716	FMN binding
APPSER1_RS06655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APPSER1_RS06660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APPSER1_RS06665	COG2252	PERMEase
APPSER1_RS06670	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APPSER1_RS06675	COG2081	HI0933 family
APPSER1_RS06680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APPSER1_RS06690	COG0560	Phosphoserine phosphatase
APPSER1_RS06705	COG0058	SHG alpha-glucan phosphorylase activity
APPSER1_RS06710	COG2909	trisaccharide binding
APPSER1_RS06720	COG4580	involved in the transport of maltose and maltodextrins
APPSER1_RS06725	COG3842	ATPase activity
APPSER1_RS06740	COG3833	ABC-type maltose transport systems, permease component
APPSER1_RS06745	COG1640	4-alpha-glucanotransferase
APPSER1_RS06750	COG1966	Carbon starvation protein
APPSER1_RS06755	COG0084	hydrolase, TatD family'
APPSER1_RS06760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APPSER1_RS06770	COG0778	Nitroreductase
APPSER1_RS06785	COG4172	Belongs to the ABC transporter superfamily
APPSER1_RS06790	COG0191	fructose-bisphosphate aldolase activity
APPSER1_RS06795	COG0126	phosphoglycerate kinase activity
APPSER1_RS06800	COG0471	metal ion transport
APPSER1_RS06805	COG0471	metal ion transport
APPSER1_RS06810	COG0471	metal ion transport
APPSER1_RS06815	COG0187	DNA topoisomerase II activity
APPSER1_RS06820	COG5002	protein histidine kinase activity
APPSER1_RS06825	COG0745	RESPONSE REGULATOR receiver
APPSER1_RS06850	COG0789	Transcriptional regulator
APPSER1_RS06870	COG0300	oxidoreductase activity
APPSER1_RS06875	COG0778	Nitroreductase
APPSER1_RS06880	COG0616	signal peptide processing
APPSER1_RS06885	COG3719	Belongs to the RNase T2 family
APPSER1_RS06895	COG1252	NADH dehydrogenase
APPSER1_RS06900	COG2183	response to ionizing radiation
APPSER1_RS06905	COG3063	Type IV pilus biogenesis stability protein PilW
APPSER1_RS06910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APPSER1_RS06945	COG2161	toxin-antitoxin pair type II binding
APPSER1_RS06950	COG4115	mRNA cleavage
APPSER1_RS06955	COG2835	tetraacyldisaccharide 4'-kinase activity
APPSER1_RS06965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APPSER1_RS06970	COG0740	serine-type endopeptidase activity
APPSER1_RS06975	COG2166	iron-sulfur cluster assembly
APPSER1_RS06995	COG0488	(ABC) transporter
APPSER1_RS07000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APPSER1_RS07015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APPSER1_RS07020	COG5007	Belongs to the BolA IbaG family
APPSER1_RS07030	COG2854	intermembrane phospholipid transfer
APPSER1_RS07035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APPSER1_RS07040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APPSER1_RS07045	COG1127	ABC transporter
APPSER1_RS07050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APPSER1_RS07055	COG1090	epimerase
APPSER1_RS07075	COG0563	adenylate kinase activity
APPSER1_RS07085	COG2814	Major facilitator Superfamily
APPSER1_RS07115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APPSER1_RS07130	COG2814	Major facilitator Superfamily
APPSER1_RS07135	COG0363	glucosamine-6-phosphate deaminase activity
APPSER1_RS07140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APPSER1_RS07145	COG1218	3'(2'),5'-bisphosphate nucleotidase
APPSER1_RS07150	COG0494	nUDIX hydrolase
APPSER1_RS07155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APPSER1_RS07165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APPSER1_RS07170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APPSER1_RS07185	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APPSER1_RS07190	COG1178	ABC-type Fe3 transport system permease component
APPSER1_RS07195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPSER1_RS07200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APPSER1_RS07205	COG2190	(PTS) system
APPSER1_RS07215	COG0210	DNA helicase
APPSER1_RS07220	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APPSER1_RS07225	COG0409	Hydrogenase expression formation protein
APPSER1_RS07230	COG0309	Hydrogenase expression formation protein (HypE)
APPSER1_RS07235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APPSER1_RS07240	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APPSER1_RS07245	COG0437	4 iron, 4 sulfur cluster binding
APPSER1_RS07250	COG5557	Pfam Polysulphide reductase, NrfD
APPSER1_RS07255	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APPSER1_RS07260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APPSER1_RS07265	COG1773	rubredoxin
APPSER1_RS07270	COG0298	carbon dioxide binding
APPSER1_RS07275	COG0375	protein maturation
APPSER1_RS07310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APPSER1_RS07315	COG0308	aminopeptidase N
APPSER1_RS07320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APPSER1_RS07325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APPSER1_RS07330	COG0295	cytidine deaminase activity
APPSER1_RS07335	COG2177	Part of the ABC transporter FtsEX involved in
APPSER1_RS07340	COG2884	Cell division ATP-binding protein ftsE
APPSER1_RS07345	COG0552	protein localization to endoplasmic reticulum
APPSER1_RS07350	COG0742	ribosomal rna small subunit methyltransferase
APPSER1_RS07355	COG3099	Belongs to the UPF0263 family
APPSER1_RS07360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APPSER1_RS07370	COG4160	amino acid transport
APPSER1_RS07375	COG4215	(ABC) transporter
APPSER1_RS07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APPSER1_RS07385	COG1126	abc transporter atp-binding protein
APPSER1_RS07390	COG1881	PFAM PEBP family protein
APPSER1_RS07400	COG3620	sequence-specific DNA binding
APPSER1_RS07410	COG4232	protein-disulfide reductase activity
APPSER1_RS07415	COG3101	peptidyl-lysine hydroxylation
APPSER1_RS07425	COG3107	peptidoglycan biosynthetic process
APPSER1_RS07430	COG0792	nuclease activity
APPSER1_RS07435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APPSER1_RS07465	COG1138	Cytochrome C-type biogenesis protein
APPSER1_RS07475	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APPSER1_RS07480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APPSER1_RS07485	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APPSER1_RS07490	COG4133	protoheme IX ABC transporter activity
APPSER1_RS07495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APPSER1_RS07530	COG3630	sodium ion export across plasma membrane
APPSER1_RS07540	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APPSER1_RS07545	COG2824	Alkylphosphonate utilization operon protein PhnA
APPSER1_RS07550	COG1858	cytochrome C peroxidase
APPSER1_RS07555	COG1872	DUF167
APPSER1_RS07560	COG0762	integral membrane protein
APPSER1_RS07565	COG3171	Protein conserved in bacteria
APPSER1_RS07570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APPSER1_RS07575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APPSER1_RS07580	COG0416	fatty acid biosynthetic process
APPSER1_RS07585	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APPSER1_RS07590	COG1399	metal-binding, possibly nucleic acid-binding protein
APPSER1_RS07595	COG4137	Cytochrome C assembly protein
APPSER1_RS07600	COG4536	flavin adenine dinucleotide binding
APPSER1_RS07605	COG0733	neurotransmitter:sodium symporter activity
APPSER1_RS07615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPSER1_RS07615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APPSER1_RS07620	COG3715	PTS system
APPSER1_RS07625	COG3716	PTS system mannose fructose sorbose family IID component
APPSER1_RS07665	COG1840	ABC-type Fe3 transport system, periplasmic component
APPSER1_RS07680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APPSER1_RS07695	COG0678	peroxiredoxin activity
APPSER1_RS07695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APPSER1_RS07700	COG0583	DNA-binding transcription factor activity
APPSER1_RS07705	COG1309	transcriptional regulator
APPSER1_RS07710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APPSER1_RS07715	COG0557	exoribonuclease II activity
APPSER1_RS07725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APPSER1_RS07730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APPSER1_RS07740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APPSER1_RS07745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APPSER1_RS07810	COG0316	Belongs to the HesB IscA family
APPSER1_RS07815	COG1575	Belongs to the MenA family. Type 1 subfamily
APPSER1_RS07820	COG1720	tRNA m6t6A37 methyltransferase activity
APPSER1_RS07830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APPSER1_RS07845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APPSER1_RS07850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APPSER1_RS07855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APPSER1_RS07865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APPSER1_RS07875	COG1755	Isoprenylcysteine carboxyl methyltransferase
APPSER1_RS07885	COG1530	ribonuclease E activity
APPSER1_RS07900	COG2249	NAD(P)H dehydrogenase (quinone) activity
APPSER1_RS07905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APPSER1_RS07915	COG0243	molybdopterin cofactor binding
APPSER1_RS07920	COG0437	4 iron, 4 sulfur cluster binding
APPSER1_RS07925	COG0348	domain, Protein
APPSER1_RS07930	COG3043	anaerobic respiration
APPSER1_RS07935	COG3005	denitrification pathway
APPSER1_RS07945	COG2050	protein possibly involved in aromatic compounds catabolism
APPSER1_RS07950	COG0277	FAD linked oxidase domain protein
APPSER1_RS07950	COG0247	lactate metabolic process
APPSER1_RS07955	COG2885	chlorophyll binding
APPSER1_RS07955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APPSER1_RS07960	COG1879	ABC-type sugar transport system periplasmic component
APPSER1_RS07965	COG1129	ABC transporter
APPSER1_RS07970	COG4211	Belongs to the binding-protein-dependent transport system permease family
APPSER1_RS07995	COG1022	Amp-dependent synthetase and ligase
APPSER1_RS08000	COG4989	oxidoreductase activity
APPSER1_RS08005	COG3691	Protein conserved in bacteria
APPSER1_RS08010	COG0814	amino acid
APPSER1_RS08030	COG4974	Belongs to the 'phage' integrase family
APPSER1_RS08060	COG1555	photosystem II stabilization
APPSER1_RS08065	COG3061	Opacity-associated protein A
APPSER1_RS08065	COG3266	domain, Protein
APPSER1_RS08075	COG0859	PFAM glycosyl transferase family 9
APPSER1_RS08080	COG0859	PFAM glycosyl transferase family 9
APPSER1_RS08085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APPSER1_RS08090	COG0049	tRNA binding
APPSER1_RS08095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APPSER1_RS08100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APPSER1_RS08125	COG0825	malonyl-CoA metabolic process
APPSER1_RS08135	COG0204	Acyl-transferase
APPSER1_RS08140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APPSER1_RS08165	COG0783	Belongs to the Dps family
APPSER1_RS08180	COG1289	transmembrane transporter activity
APPSER1_RS08185	COG1803	Methylglyoxal synthase
APPSER1_RS08190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APPSER1_RS08200	COG0525	valine-tRNA ligase activity
APPSER1_RS08210	COG2153	protein acetylation
APPSER1_RS08215	COG2927	DNA polymerase III (CHI subunit)
APPSER1_RS08220	COG1652	LysM domain
APPSER1_RS08230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APPSER1_RS08235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APPSER1_RS08240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APPSER1_RS08245	COG1045	serine acetyltransferase
APPSER1_RS08250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APPSER1_RS08275	COG1072	(Pantothenic acid kinase))
APPSER1_RS08280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APPSER1_RS08295	COG0521	Mo-molybdopterin cofactor biosynthetic process
APPSER1_RS08305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APPSER1_RS08310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APPSER1_RS08315	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APPSER1_RS08330	COG0625	glutathione transferase activity
APPSER1_RS08335	COG0019	diaminopimelate decarboxylase activity
APPSER1_RS08345	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APPSER1_RS08350	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APPSER1_RS08355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APPSER1_RS08360	COG1053	succinate dehydrogenase
APPSER1_RS08365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APPSER1_RS08370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APPSER1_RS08375	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APPSER1_RS08380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APPSER1_RS08390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APPSER1_RS08395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APPSER1_RS08400	COG2264	protein methyltransferase activity
APPSER1_RS08420	COG0037	tRNA processing
APPSER1_RS08430	COG4974	Belongs to the 'phage' integrase family
APPSER1_RS08490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APPSER1_RS08505	COG1151	hydroxylamine reductase activity
APPSER1_RS08510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APPSER1_RS08515	COG2244	polysaccharide biosynthetic process
APPSER1_RS08520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APPSER1_RS08530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APPSER1_RS08535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APPSER1_RS08540	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APPSER1_RS08560	COG0728	peptidoglycan biosynthetic process
APPSER1_RS08565	COG0268	Binds directly to 16S ribosomal RNA
APPSER1_RS08570	COG0569	domain protein
APPSER1_RS08575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APPSER1_RS08580	COG3276	selenocysteine insertion sequence binding
APPSER1_RS08595	COG0716	FMN binding
APPSER1_RS08620	COG4771	TonB-dependent receptor
APPSER1_RS08620	COG1629	transport
APPSER1_RS08645	COG2431	L-lysine efflux transmembrane transporter activity
APPSER1_RS08655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APPSER1_RS08660	COG3545	Serine hydrolase
APPSER1_RS08695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
APPSER1_RS08695	COG1215	transferase activity, transferring glycosyl groups
APPSER1_RS08725	COG1119	ATPase activity
APPSER1_RS08740	COG1739	Uncharacterized protein family UPF0029
APPSER1_RS08745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APPSER1_RS08750	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APPSER1_RS08755	COG1970	mechanosensitive ion channel activity
APPSER1_RS08760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APPSER1_RS08765	COG0321	lipoyl(octanoyl) transferase activity
APPSER1_RS08770	COG2921	Belongs to the UPF0250 family
APPSER1_RS08775	COG1686	Belongs to the peptidase S11 family
APPSER1_RS08780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APPSER1_RS08785	COG0772	Belongs to the SEDS family
APPSER1_RS08790	COG0768	penicillin binding
APPSER1_RS08795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APPSER1_RS08800	COG0799	negative regulation of ribosome biogenesis
APPSER1_RS08815	COG0765	amino acid transport
APPSER1_RS08820	COG3681	Belongs to the UPF0597 family
APPSER1_RS08825	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
APPSER1_RS08835	COG3691	Protein conserved in bacteria
APPSER1_RS08885	COG0831	urea catabolic process
APPSER1_RS08895	COG1122	ATPase activity
APPSER1_RS08900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APPSER1_RS08905	COG0310	cobalt ion transport
APPSER1_RS08910	COG0310	cobalt ion transport
APPSER1_RS08915	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
APPSER1_RS08920	COG0583	DNA-binding transcription factor activity
APPSER1_RS08930	COG0490	domain, Protein
APPSER1_RS08930	COG0471	metal ion transport
APPSER1_RS08935	COG3722	fumarate hydratase activity
APPSER1_RS08950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APPSER1_RS08955	COG1349	DNA-binding transcription factor activity
APPSER1_RS08970	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
APPSER1_RS08980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APPSER1_RS08985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APPSER1_RS08990	COG2900	Belongs to the SlyX family
APPSER1_RS08995	COG0545	Peptidyl-prolyl cis-trans isomerase
APPSER1_RS09000	COG2964	Protein conserved in bacteria
APPSER1_RS09005	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APPSER1_RS09015	COG2168	tRNA wobble position uridine thiolation
APPSER1_RS09045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APPSER1_RS09050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APPSER1_RS09055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APPSER1_RS09060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APPSER1_RS09085	COG0357	Ribosomal RNA small subunit methyltransferase G
APPSER1_RS09090	COG0445	tRNA wobble uridine modification
APPSER1_RS09095	COG0561	phosphatase activity
APPSER1_RS09100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APPSER1_RS09105	COG3012	SEC-C Motif Domain Protein
APPSER1_RS09115	COG3716	PTS system mannose fructose sorbose family IID component
APPSER1_RS09120	COG3715	PTS system
APPSER1_RS09125	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPSER1_RS09125	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APPSER1_RS09130	COG2610	gluconate transmembrane transporter activity
APPSER1_RS09135	COG3265	gluconokinase activity
APPSER1_RS09140	COG1609	Transcriptional regulator
APPSER1_RS09145	COG1609	Transcriptional regulator
APPSER1_RS09160	COG1172	Belongs to the binding-protein-dependent transport system permease family
APPSER1_RS09165	COG1879	ABC-type sugar transport system periplasmic component
APPSER1_RS09170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APPSER1_RS09175	COG0243	molybdopterin cofactor binding
APPSER1_RS09180	COG0437	4 iron, 4 sulfur cluster binding
APPSER1_RS09185	COG3302	dmso reductase anchor subunit
APPSER1_RS09190	COG3381	protein complex oligomerization
APPSER1_RS09195	COG2221	Nitrite and sulphite reductase 4Fe-4S
APPSER1_RS09195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APPSER1_RS09220	COG1349	DNA-binding transcription factor activity
APPSER1_RS09225	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
APPSER1_RS09230	COG1070	Carbohydrate kinase
APPSER1_RS09235	COG4154	Belongs to the RbsD FucU family
APPSER1_RS09240	COG0235	Class ii aldolase
APPSER1_RS09245	COG0738	Major facilitator superfamily
APPSER1_RS09250	COG1454	alcohol dehydrogenase
APPSER1_RS09255	COG3477	response to acidic pH
APPSER1_RS09260	COG0765	amino acid transport
APPSER1_RS09270	COG1126	abc transporter atp-binding protein
APPSER1_RS09275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APPSER1_RS09295	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APPSER1_RS09320	COG3623	hexulose-6-phosphate isomerase
APPSER1_RS09325	COG0235	Class ii aldolase
APPSER1_RS09330	COG0545	Peptidyl-prolyl cis-trans isomerase
APPSER1_RS09350	COG4783	chaperone-mediated protein folding
APPSER1_RS09355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APPSER1_RS09365	COG0758	DNA mediated transformation
APPSER1_RS09370	COG1297	OPT oligopeptide transporter protein
APPSER1_RS09385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APPSER1_RS09395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APPSER1_RS09400	COG0081	regulation of translation
APPSER1_RS09405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APPSER1_RS09410	COG0222	ribosome binding
APPSER1_RS09475	COG1487	ribonuclease activity
APPSER1_RS09490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APPSER1_RS09495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APPSER1_RS09505	COG0346	lactoylglutathione lyase activity
APPSER1_RS09510	COG1194	a g-specific adenine glycosylase
APPSER1_RS09515	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APPSER1_RS09520	COG0741	lytic transglycosylase activity
APPSER1_RS09545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APPSER1_RS09550	COG0737	Belongs to the 5'-nucleotidase family
APPSER1_RS09555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APPSER1_RS09560	COG0606	chelatase, subunit chli
APPSER1_RS09570	COG2267	carboxylic ester hydrolase activity
APPSER1_RS09575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APPSER1_RS09585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APPSER1_RS09595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APPSER1_RS09600	COG0363	glucosamine-6-phosphate deaminase activity
APPSER1_RS09605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APPSER1_RS09620	COG0051	transcription antitermination factor activity, RNA binding
APPSER1_RS09625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APPSER1_RS09630	COG0088	Forms part of the polypeptide exit tunnel
APPSER1_RS09635	COG0089	rRNA binding
APPSER1_RS09640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APPSER1_RS09645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APPSER1_RS09650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APPSER1_RS09655	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APPSER1_RS09660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APPSER1_RS09665	COG0255	Belongs to the universal ribosomal protein uL29 family
APPSER1_RS09670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APPSER1_RS09680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APPSER1_RS09685	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APPSER1_RS09690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APPSER1_RS09695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APPSER1_RS09700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APPSER1_RS09705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APPSER1_RS09710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APPSER1_RS09715	COG1841	ribosomal large subunit assembly
APPSER1_RS09720	COG0200	Binds to the 23S rRNA
APPSER1_RS09725	COG0201	protein transport
APPSER1_RS09735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APPSER1_RS09740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APPSER1_RS09745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APPSER1_RS09750	COG0202	RNA polymerase activity
APPSER1_RS09760	COG0228	four-way junction DNA binding
APPSER1_RS09765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APPSER1_RS09770	COG0336	Belongs to the RNA methyltransferase TrmD family
APPSER1_RS09775	COG0335	large ribosomal subunit rRNA binding
APPSER1_RS09780	COG2850	peptidyl-arginine hydroxylation
APPSER1_RS09785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APPSER1_RS09790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APPSER1_RS09795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APPSER1_RS09835	COG2852	Protein conserved in bacteria
APPSER1_RS09860	COG2832	Protein of unknown function (DUF454)
APPSER1_RS09865	COG1215	transferase activity, transferring glycosyl groups
APPSER1_RS09870	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APPSER1_RS09880	COG0084	hydrolase, TatD family'
APPSER1_RS09895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APPSER1_RS09905	COG0470	DNA polymerase III
APPSER1_RS09910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APPSER1_RS09915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APPSER1_RS09935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APPSER1_RS09940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APPSER1_RS09945	COG0254	rRNA binding
APPSER1_RS09950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APPSER1_RS09955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APPSER1_RS09960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APPSER1_RS09965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APPSER1_RS09975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APPSER1_RS09990	COG0442	prolyl-tRNA aminoacylation
APPSER1_RS10000	COG1595	DNA-templated transcription, initiation
APPSER1_RS10005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APPSER1_RS10015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APPSER1_RS10040	COG2502	aspartate--ammonia ligase
APPSER1_RS10045	COG1522	sequence-specific DNA binding
APPSER1_RS10050	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APPSER1_RS10055	COG3161	chorismate lyase activity
APPSER1_RS10115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APPSER1_RS10125	COG4208	sulfate ABC transporter
APPSER1_RS10130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APPSER1_RS10140	COG1304	FMN binding
APPSER1_RS10150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APPSER1_RS10160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APPSER1_RS10165	COG2995	paraquat-inducible protein a
APPSER1_RS10170	COG1305	Transglutaminase-like
APPSER1_RS10180	COG2608	mercury ion transmembrane transporter activity
APPSER1_RS10185	COG1979	alcohol dehydrogenase
APPSER1_RS10190	COG0583	DNA-binding transcription factor activity
APPSER1_RS10195	COG2171	N-acyltransferase activity
APPSER1_RS10200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APPSER1_RS10210	COG0511	ligase activity, forming carbon-carbon bonds
APPSER1_RS10215	COG0439	Biotin carboxylase
APPSER1_RS10220	COG1763	Mo-molybdopterin cofactor biosynthetic process
APPSER1_RS10225	COG3084	Protein conserved in bacteria
APPSER1_RS10230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APPSER1_RS10240	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APPSER1_RS10240	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APPSER1_RS10250	COG1876	peptidase activity
APPSER1_RS10255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APPSER1_RS10260	COG1393	Belongs to the ArsC family
APPSER1_RS10270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APPSER1_RS10275	COG0564	pseudouridine synthase activity
APPSER1_RS10285	COG0668	transmembrane transport
APPSER1_RS10290	COG0439	Biotin carboxylase
APPSER1_RS10300	COG1025	Belongs to the peptidase M16 family
APPSER1_RS10305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APPSER1_RS10330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APPSER1_RS10335	COG1067	ATP-dependent peptidase activity
APPSER1_RS10340	COG3120	sequence-specific DNA binding
APPSER1_RS10345	COG0180	Tryptophanyl-tRNA synthetase
APPSER1_RS10365	COG0730	response to heat
APPSER1_RS10380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APPSER1_RS10390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APPSER1_RS10395	COG2116	formate transmembrane transporter activity
APPSER1_RS10420	COG0443	Heat shock 70 kDa protein
APPSER1_RS10425	COG1070	Carbohydrate kinase
APPSER1_RS10430	COG2115	Belongs to the xylose isomerase family
APPSER1_RS10435	COG4213	ABC transporter substrate-binding protein
APPSER1_RS10440	COG1129	ABC transporter
APPSER1_RS10445	COG4214	carbohydrate transport
APPSER1_RS10450	COG1609	Transcriptional regulator
APPSER1_RS10450	COG2207	Transcriptional regulator
APPSER1_RS10455	COG3590	peptidase
APPSER1_RS10465	COG4145	pantothenate transmembrane transporter activity
APPSER1_RS10470	COG3924	membrane
APPSER1_RS10475	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
APPSER1_RS10480	COG2853	Lipoprotein
APPSER1_RS10485	COG0676	glucose-6-phosphate 1-epimerase activity
APPSER1_RS10500	COG0726	polysaccharide deacetylase
APPSER1_RS10500	COG1649	PFAM Uncharacterised BCR, COG1649
APPSER1_RS10505	COG1215	transferase activity, transferring glycosyl groups
APPSER1_RS10515	COG0149	triose-phosphate isomerase activity
APPSER1_RS10525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APPSER1_RS10530	COG1238	metal cluster binding
APPSER1_RS10545	COG4942	peptidase
APPSER1_RS10545	COG1388	LysM domain
APPSER1_RS10550	COG2818	Glycosylase
APPSER1_RS10560	COG0700	Nucleoside recognition
APPSER1_RS10565	COG3366	ferrous iron transmembrane transporter activity
APPSER1_RS10570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APPSER1_RS10575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APPSER1_RS10580	COG0594	ribonuclease P activity
APPSER1_RS10585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APPSER1_RS10590	COG0174	glutamine synthetase
APPSER1_RS10595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APPSER1_RS10600	COG0494	nUDIX hydrolase
APPSER1_RS10630	COG1490	D-aminoacyl-tRNA deacylase activity
APPSER1_RS10635	COG1295	ribonuclease BN
APPSER1_RS10640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APPSER1_RS10665	COG1064	alcohol dehydrogenase
APPSER1_RS10675	COG1923	regulation of RNA biosynthetic process
APPSER1_RS10680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APPSER1_RS10690	COG1694	Mazg nucleotide pyrophosphohydrolase
APPSER1_RS10705	COG1309	transcriptional regulator
APPSER1_RS10715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APPSER1_RS10720	COG2003	Belongs to the UPF0758 family
APPSER1_RS10725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APPSER1_RS10730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APPSER1_RS10740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APPSER1_RS10745	COG0076	glutamate decarboxylase activity
APPSER1_RS10750	COG0425	Belongs to the sulfur carrier protein TusA family
APPSER1_RS10755	COG2391	methyltransferase activity
APPSER1_RS10760	COG3085	chromosome segregation
APPSER1_RS10780	COG0598	Magnesium transport protein CorA
APPSER1_RS10785	COG2226	methyltransferase
APPSER1_RS10795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APPSER1_RS10800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APPSER1_RS10805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APPSER1_RS10810	COG0805	protein transport
APPSER1_RS10830	COG1114	Component of the transport system for branched-chain amino acids
APPSER1_RS10835	COG1028	Short-chain dehydrogenase reductase Sdr
APPSER1_RS10840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APPSER1_RS10845	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APPSER1_RS10850	COG0142	geranyltranstransferase activity
APPSER1_RS10860	COG0431	NADPH-dependent FMN reductase
APPSER1_RS10865	COG2259	Doxx family
APPSER1_RS10870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APPSER1_RS10875	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APPSER1_RS10880	COG0697	spore germination
APPSER1_RS10885	COG4783	chaperone-mediated protein folding
APPSER1_RS10895	COG1040	competence protein
APPSER1_RS10910	COG0456	acetyltransferase
APPSER1_RS10915	COG0513	Belongs to the DEAD box helicase family
APPSER1_RS10925	COG0747	negative chemotaxis
APPSER1_RS10935	COG1584	GPR1 FUN34 yaaH family protein
APPSER1_RS10940	COG1120	ATPase activity
APPSER1_RS10975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APPSER1_RS10980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APPSER1_RS11000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APPSER1_RS11015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APPSER1_RS11015	COG0140	phosphoribosyl-ATP diphosphatase activity
APPSER1_RS11020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APPSER1_RS11025	COG0024	Methionine aminopeptidase
APPSER1_RS11040	COG1621	beta-fructofuranosidase activity
APPSER1_RS11045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APPSER1_RS11055	COG4591	ABC-type transport system involved in lipoprotein release permease component
APPSER1_RS11060	COG1136	(ABC) transporter
APPSER1_RS11065	COG4591	ABC-type transport system involved in lipoprotein release permease component
APPSER1_RS11070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family