locus-tag	class	description
D1095_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1095_RS00010	COG0592	DNA-directed DNA polymerase activity
D1095_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1095_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1095_RS00040	COG0616	signal peptide processing
D1095_RS00055	COG3116	cell division
D1095_RS00060	COG0768	penicillin binding
D1095_RS00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1095_RS00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1095_RS00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1095_RS00085	COG0772	Belongs to the SEDS family
D1095_RS00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1095_RS00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1095_RS00110	COG0849	cell division
D1095_RS00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1095_RS00125	COG0497	DNA recombination
D1095_RS00135	COG4172	Belongs to the ABC transporter superfamily
D1095_RS00140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1095_RS00145	COG0601	transmembrane transport
D1095_RS00175	COG0012	GTP binding
D1095_RS00180	COG2020	methyltransferase activity
D1095_RS00190	COG3133	Outer membrane lipoprotein
D1095_RS00195	COG3102	Protein conserved in bacteria
D1095_RS00200	COG0018	arginyl-trna synthetase
D1095_RS00215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1095_RS00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1095_RS00225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1095_RS00230	COG0196	riboflavin kinase activity
D1095_RS00235	COG3172	ATPase kinase involved in NAD metabolism
D1095_RS00240	COG2129	metallophosphoesterase
D1095_RS00245	COG0745	RESPONSE REGULATOR receiver
D1095_RS00255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1095_RS00260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1095_RS00270	COG1217	gtp-binding protein TYPA
D1095_RS00275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1095_RS00280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1095_RS00285	COG1561	YicC-like family, N-terminal region
D1095_RS00290	COG0354	folic acid binding
D1095_RS00295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1095_RS00300	COG2197	response regulator
D1095_RS00310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1095_RS00350	COG0747	negative chemotaxis
D1095_RS00355	COG0601	transmembrane transport
D1095_RS00360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1095_RS00365	COG0444	Belongs to the ABC transporter superfamily
D1095_RS00370	COG4608	Belongs to the ABC transporter superfamily
D1095_RS00385	COG0251	oxidation-reduction process
D1095_RS00390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1095_RS00395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1095_RS00400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1095_RS00405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1095_RS00410	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D1095_RS00415	COG0848	biopolymer transport protein
D1095_RS00420	COG0811	peptide transport
D1095_RS00425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1095_RS00430	COG3118	belongs to the thioredoxin family
D1095_RS00435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1095_RS00435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_RS00435	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D1095_RS00440	COG1461	Dihydroxyacetone kinase
D1095_RS00445	COG2376	Dihydroxyacetone kinase
D1095_RS00450	COG0492	ferredoxin-NADP+ reductase activity
D1095_RS00460	COG3753	Protein conserved in bacteria
D1095_RS00480	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1095_RS00485	COG0006	proline dipeptidase activity
D1095_RS00495	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D1095_RS00520	COG3978	acetolactate synthase activity
D1095_RS00535	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D1095_RS00540	COG0437	4 iron, 4 sulfur cluster binding
D1095_RS00545	COG3301	Polysulphide reductase, NrfD
D1095_RS00570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1095_RS00575	COG1414	Transcriptional regulator
D1095_RS00580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1095_RS00590	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D1095_RS00600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1095_RS00605	COG3068	Protein conserved in bacteria
D1095_RS00625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1095_RS00630	COG1278	Cold shock
D1095_RS00635	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D1095_RS00640	COG0793	Belongs to the peptidase S41A family
D1095_RS00645	COG2989	Protein conserved in bacteria
D1095_RS00650	COG3108	Peptidase M15
D1095_RS00655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1095_RS00670	COG0537	adenosine 5'-monophosphoramidase activity
D1095_RS00675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1095_RS00680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1095_RS00685	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1095_RS00690	COG1162	GTPase activity
D1095_RS00695	COG0583	DNA-binding transcription factor activity
D1095_RS00700	COG1011	Hydrolase
D1095_RS00705	COG0583	DNA-binding transcription factor activity
D1095_RS00715	COG0252	asparaginase activity
D1095_RS00725	COG5413	integral membrane protein
D1095_RS00740	COG3835	regulator
D1095_RS00745	COG2610	gluconate transmembrane transporter activity
D1095_RS00750	COG1929	Belongs to the glycerate kinase type-1 family
D1095_RS00755	COG1254	Belongs to the acylphosphatase family
D1095_RS00760	COG3593	DNA synthesis involved in DNA repair
D1095_RS00765	COG1611	Belongs to the LOG family
D1095_RS00770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1095_RS00780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1095_RS00785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D1095_RS00785	COG0316	Belongs to the HesB IscA family
D1095_RS00790	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_RS00795	COG1805	sodium ion transport
D1095_RS00800	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_RS00805	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_RS00810	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_RS00815	COG2871	sodium ion transport
D1095_RS00820	COG1477	protein flavinylation
D1095_RS00825	COG2991	Protein conserved in bacteria
D1095_RS00830	COG0482	sulfurtransferase activity
D1095_RS00835	COG2814	Major facilitator Superfamily
D1095_RS00840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1095_RS00845	COG2974	May be involved in recombination
D1095_RS00850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1095_RS00865	COG4657	Part of a membrane complex involved in electron transport
D1095_RS00870	COG2878	Part of a membrane complex involved in electron transport
D1095_RS00875	COG4656	Part of a membrane complex involved in electron transport
D1095_RS00900	COG1560	Kdo2-lipid A biosynthetic process
D1095_RS00905	COG0402	S-adenosylhomocysteine deaminase activity
D1095_RS00910	COG4143	(ABC) transporter
D1095_RS00915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1095_RS00920	COG0617	tRNA 3'-terminal CCA addition
D1095_RS00925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1095_RS00935	COG2911	Protein conserved in bacteria
D1095_RS00945	COG0346	lactoylglutathione lyase activity
D1095_RS00950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1095_RS00960	COG0287	Prephenate dehydrogenase
D1095_RS00960	COG1605	Chorismate mutase
D1095_RS00965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1095_RS00970	COG0859	PFAM glycosyl transferase family 9
D1095_RS00975	COG0469	pyruvate kinase activity
D1095_RS00980	COG2062	phosphohistidine phosphatase, SixA
D1095_RS00985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1095_RS00990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D1095_RS00995	COG0733	neurotransmitter:sodium symporter activity
D1095_RS01000	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D1095_RS01005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1095_RS01010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1095_RS01015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1095_RS01020	COG4972	Pilus assembly protein
D1095_RS01040	COG4796	Type ii and iii secretion system protein
D1095_RS01045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1095_RS01050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1095_RS01055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D1095_RS01060	COG1280	lysine exporter protein (LysE YggA)
D1095_RS01065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1095_RS01075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1095_RS01090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1095_RS01145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1095_RS01150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1095_RS01155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1095_RS01170	COG1253	flavin adenine dinucleotide binding
D1095_RS01175	COG0564	pseudouridine synthase activity
D1095_RS01180	COG0588	phosphoglycerate mutase activity
D1095_RS01185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1095_RS01190	COG1678	Uncharacterized ACR, COG1678
D1095_RS01195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1095_RS01205	COG0271	Belongs to the BolA IbaG family
D1095_RS01230	COG0653	protein targeting
D1095_RS01240	COG0494	nUDIX hydrolase
D1095_RS01245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1095_RS01255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1095_RS01265	COG4771	TonB-dependent receptor
D1095_RS01265	COG1629	transport
D1095_RS01270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1095_RS01275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1095_RS01280	COG0083	homoserine kinase activity
D1095_RS01285	COG0460	homoserine dehydrogenase
D1095_RS01285	COG0527	aspartate kinase activity
D1095_RS01290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1095_RS01295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1095_RS01300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1095_RS01330	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1095_RS01335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1095_RS01340	COG0194	GDP metabolic process
D1095_RS01345	COG1538	Outer membrane efflux protein
D1095_RS01350	COG2914	Belongs to the UPF0125 (RnfH) family
D1095_RS01355	COG2867	negative regulation of translational initiation
D1095_RS01360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1095_RS01365	COG4149	molybdate abc transporter
D1095_RS01370	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1095_RS01375	COG0842	Transport permease protein
D1095_RS01380	COG1131	(ABC) transporter
D1095_RS01385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1095_RS01390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1095_RS01400	COG0251	oxidation-reduction process
D1095_RS01405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1095_RS01410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1095_RS01415	COG1121	(ABC) transporter
D1095_RS01425	COG2920	part of a sulfur-relay system
D1095_RS01430	COG0670	Belongs to the BI1 family
D1095_RS01435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1095_RS01445	COG0322	excinuclease ABC activity
D1095_RS01450	COG0084	hydrolase, TatD family'
D1095_RS01455	COG0210	DNA helicase
D1095_RS01460	COG3842	ATPase activity
D1095_RS01465	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1095_RS01470	COG1177	transmembrane transport
D1095_RS01475	COG0632	four-way junction helicase activity
D1095_RS01480	COG2255	four-way junction helicase activity
D1095_RS01485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1095_RS01490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1095_RS01540	COG0488	(ABC) transporter
D1095_RS01545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1095_RS01555	COG1271	oxidase subunit
D1095_RS01560	COG1294	oxidase, subunit
D1095_RS01575	COG0824	Thioesterase
D1095_RS01580	COG0811	peptide transport
D1095_RS01585	COG0848	biopolymer transport protein
D1095_RS01590	COG3064	Membrane
D1095_RS01590	COG3064	Membrane
D1095_RS01595	COG0823	Involved in the tonB-independent uptake of proteins
D1095_RS01610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1095_RS01615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1095_RS01625	COG0488	(ABC) transporter
D1095_RS01635	COG0303	'Molybdopterin
D1095_RS01640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1095_RS01650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1095_RS01655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1095_RS01660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1095_RS01665	COG0564	pseudouridine synthase activity
D1095_RS01670	COG3023	N-Acetylmuramoyl-L-alanine amidase
D1095_RS01675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1095_RS01680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1095_RS01685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1095_RS01690	COG0626	cystathionine gamma-synthase activity
D1095_RS01695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1095_RS01710	COG1702	phosphate starvation-inducible protein PhoH
D1095_RS01735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1095_RS01755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1095_RS01765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_RS01770	COG1137	ATPase activity
D1095_RS01775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D1095_RS01785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1095_RS01790	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D1095_RS01800	COG1704	LemA family
D1095_RS01805	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D1095_RS01805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1095_RS01805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1095_RS01810	COG1105	Belongs to the carbohydrate kinase PfkB family
D1095_RS01815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_RS01815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_RS01825	COG1523	belongs to the glycosyl hydrolase 13 family
D1095_RS01830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1095_RS01835	COG0297	glycogen (starch) synthase activity
D1095_RS01840	COG0058	SHG alpha-glucan phosphorylase activity
D1095_RS01845	COG0105	UTP biosynthetic process
D1095_RS01865	COG1187	pseudouridine synthase activity
D1095_RS01870	COG2814	Major facilitator Superfamily
D1095_RS01880	COG3381	protein complex oligomerization
D1095_RS01890	COG0791	NLP P60 protein
D1095_RS01895	COG2932	Transcriptional regulator
D1095_RS01900	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D1095_RS01905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1095_RS01910	COG2990	Protein conserved in bacteria
D1095_RS01920	COG1643	Atp-dependent helicase
D1095_RS01925	COG2707	UPF0756 membrane protein
D1095_RS01930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1095_RS01935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1095_RS01940	COG0534	Mate efflux family protein
D1095_RS01945	COG1074	ATP-dependent DNA helicase activity
D1095_RS01950	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1095_RS01955	COG4535	Mg2 and Co2 transporter CorC
D1095_RS01965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1095_RS01970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1095_RS01975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1095_RS01980	COG2271	Major facilitator Superfamily
D1095_RS01985	COG0584	glycerophosphoryl diester phosphodiesterase
D1095_RS01990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1095_RS01995	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
D1095_RS02000	COG0247	lactate metabolic process
D1095_RS02030	COG0517	IMP dehydrogenase activity
D1095_RS02030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1095_RS02040	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D1095_RS02045	COG0385	Bile acid
D1095_RS02050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_RS02055	COG0561	phosphatase activity
D1095_RS02070	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D1095_RS02080	COG0318	PFAM AMP-dependent synthetase and ligase
D1095_RS02085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1095_RS02090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1095_RS02095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1095_RS02100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1095_RS02105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1095_RS02105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1095_RS02110	COG1160	GTP binding
D1095_RS02120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1095_RS02135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1095_RS02140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1095_RS02155	COG0750	zinc metalloprotease
D1095_RS02160	COG0575	Belongs to the CDS family
D1095_RS02165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1095_RS02170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1095_RS02180	COG0671	phosphoesterase, PA-phosphatase related
D1095_RS02185	COG1534	Rna-binding protein
D1095_RS02190	COG0463	Glycosyl transferase, family 2
D1095_RS02195	COG1686	Belongs to the peptidase S11 family
D1095_RS02200	COG0859	PFAM glycosyl transferase family 9
D1095_RS02210	COG0328	RNA-DNA hybrid ribonuclease activity
D1095_RS02215	COG1286	toxin biosynthetic process
D1095_RS02220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1095_RS02230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1095_RS02235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1095_RS02245	COG0251	oxidation-reduction process
D1095_RS02250	COG1496	oxidoreductase activity
D1095_RS02260	COG5645	(Lipo)protein
D1095_RS02275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1095_RS02285	COG1792	Involved in formation and maintenance of cell shape
D1095_RS02290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D1095_RS02295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1095_RS02300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1095_RS02305	COG0121	glutamine amidotransferase
D1095_RS02310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1095_RS02315	COG2949	membrane
D1095_RS02330	COG1556	Lactate utilization protein
D1095_RS02335	COG1139	Iron-sulfur cluster binding protein
D1095_RS02340	COG0247	lactate metabolic process
D1095_RS02345	COG1620	l-lactate permease
D1095_RS02350	COG2916	Histone family protein nucleoid-structuring protein H-NS
D1095_RS02355	COG1757	Na H antiporter
D1095_RS02360	COG1879	ABC-type sugar transport system periplasmic component
D1095_RS02365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1095_RS02370	COG0045	succinate-CoA ligase (ADP-forming) activity
D1095_RS02375	COG2990	Protein conserved in bacteria
D1095_RS02380	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1095_RS02385	COG0567	Dehydrogenase, E1 component
D1095_RS02390	COG1121	(ABC) transporter
D1095_RS02395	COG0739	heme binding
D1095_RS02400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1095_RS02405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1095_RS02415	COG0561	phosphatase activity
D1095_RS02420	COG3850	Histidine kinase
D1095_RS02430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1095_RS02435	COG0393	Putative heavy-metal-binding
D1095_RS02440	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1095_RS02450	COG4221	oxidoreductase activity
D1095_RS02470	COG2801	Transposase and inactivated derivatives
D1095_RS02480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1095_RS02480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1095_RS02485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D1095_RS02495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1095_RS02500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1095_RS02525	COG0640	Transcriptional regulator
D1095_RS02535	COG0189	ligase activity
D1095_RS02540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1095_RS02545	COG0281	malic enzyme
D1095_RS02545	COG0280	phosphate acetyltransferase
D1095_RS02560	COG3683	transport system, periplasmic component
D1095_RS02565	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D1095_RS02570	COG1115	amino acid carrier protein
D1095_RS02580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1095_RS02590	COG2104	thiamine diphosphate biosynthetic process
D1095_RS02600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1095_RS02605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1095_RS02610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1095_RS02625	COG0481	GTPase activity
D1095_RS02630	COG0681	Belongs to the peptidase S26 family
D1095_RS02635	COG0571	ribonuclease III activity
D1095_RS02640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1095_RS02645	COG1381	Involved in DNA repair and RecF pathway recombination
D1095_RS02710	COG0433	COG0433 Predicted ATPase
D1095_RS02725	COG1840	ABC-type Fe3 transport system, periplasmic component
D1095_RS02740	COG4178	(ABC) transporter
D1095_RS02750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1095_RS02755	COG2194	sulfuric ester hydrolase activity
D1095_RS02760	COG0528	UMP kinase activity
D1095_RS02765	COG0233	cytoplasmic translational termination
D1095_RS02770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1095_RS02775	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1095_RS02785	COG0590	tRNA wobble adenosine to inosine editing
D1095_RS02790	COG0513	Belongs to the DEAD box helicase family
D1095_RS02795	COG4785	May be involved in cell division
D1095_RS02800	COG1185	polyribonucleotide nucleotidyltransferase activity
D1095_RS02805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1095_RS02815	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D1095_RS02830	COG3083	sulfuric ester hydrolase activity
D1095_RS02835	COG3082	Protein of unknown function (DUF1414)
D1095_RS02840	COG1309	transcriptional regulator
D1095_RS02845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_RS02850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1095_RS02855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1095_RS02865	COG3955	Domain of unknown function (DUF1919)
D1095_RS02870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1095_RS02885	COG0517	IMP dehydrogenase activity
D1095_RS02885	COG0516	GMP reductase activity
D1095_RS02890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1095_RS02895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1095_RS02900	COG0814	amino acid
D1095_RS02905	COG0814	amino acid
D1095_RS02915	COG3105	Protein conserved in bacteria
D1095_RS02920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1095_RS02930	COG3022	response to hydroperoxide
D1095_RS02945	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D1095_RS02950	COG1823	symporter activity
D1095_RS02955	COG0778	Nitroreductase
D1095_RS02965	COG0072	phenylalanine-tRNA ligase activity
D1095_RS02970	COG0776	regulation of translation
D1095_RS02975	COG0791	NLP P60 protein
D1095_RS02985	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1095_RS02990	COG1940	carbohydrate kinase activity
D1095_RS02990	COG1846	Transcriptional regulator
D1095_RS02995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1095_RS03000	COG1522	sequence-specific DNA binding
D1095_RS03005	COG1674	ftsk spoiiie
D1095_RS03010	COG2321	neutral zinc metallopeptidase
D1095_RS03015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1095_RS03020	COG1214	PFAM Peptidase M22, glycoprotease
D1095_RS03025	COG1435	thymidine kinase activity
D1095_RS03030	COG3074	FtsZ-dependent cytokinesis
D1095_RS03035	COG1494	fructose-1,6-bisphosphatase
D1095_RS03040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1095_RS03045	COG1136	(ABC) transporter
D1095_RS03045	COG0577	efflux transmembrane transporter activity
D1095_RS03050	COG2205	protein histidine kinase activity
D1095_RS03055	COG0745	RESPONSE REGULATOR receiver
D1095_RS03060	COG3956	TIGRFAM MazG family protein
D1095_RS03070	COG0285	dihydrofolate synthase activity
D1095_RS03080	COG0779	Required for maturation of 30S ribosomal subunits
D1095_RS03085	COG0195	Participates in both transcription termination and antitermination
D1095_RS03090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1095_RS03095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1095_RS03100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1095_RS03105	COG2951	lytic endotransglycosylase activity
D1095_RS03115	COG0857	belongs to the CobB CobQ family
D1095_RS03115	COG0280	phosphate acetyltransferase
D1095_RS03125	COG0737	Belongs to the 5'-nucleotidase family
D1095_RS03145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1095_RS03155	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D1095_RS03165	COG0589	response to stress
D1095_RS03175	COG2969	positive regulation of protein catabolic process
D1095_RS03180	COG0625	glutathione transferase activity
D1095_RS03185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1095_RS03195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1095_RS03200	COG1448	Aminotransferase
D1095_RS03205	COG0006	proline dipeptidase activity
D1095_RS03215	COG0556	nucleotide-excision repair
D1095_RS03220	COG2822	iron ion transport
D1095_RS03225	COG2837	iron assimilation
D1095_RS03235	COG0613	PHP domain protein
D1095_RS03245	COG2925	Exonuclease
D1095_RS03250	COG0038	chloride channel
D1095_RS03260	COG1509	lysine 2,3-aminomutase activity
D1095_RS03270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1095_RS03275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1095_RS03285	COG2814	Major facilitator Superfamily
D1095_RS03290	COG0741	lytic transglycosylase activity
D1095_RS03295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1095_RS03300	COG0626	cystathionine gamma-synthase activity
D1095_RS03305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1095_RS03310	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D1095_RS03315	COG2363	Small membrane protein
D1095_RS03320	COG0277	FAD linked oxidase domain protein
D1095_RS03325	COG0243	molybdopterin cofactor binding
D1095_RS03330	COG3005	denitrification pathway
D1095_RS03335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1095_RS03340	COG0315	cyclic pyranopterin monophosphate synthase activity
D1095_RS03345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D1095_RS03350	COG0314	molybdopterin synthase activity
D1095_RS03355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1095_RS03360	COG1444	tRNA N-acetyltransferase activity
D1095_RS03370	COG0583	DNA-binding transcription factor activity
D1095_RS03395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1095_RS03400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1095_RS03415	COG1737	Transcriptional regulator
D1095_RS03420	COG2731	YhcH YjgK YiaL family protein
D1095_RS03425	COG0248	Ppx GppA phosphatase
D1095_RS03430	COG2926	Belongs to the UPF0265 family
D1095_RS03435	COG0527	aspartate kinase activity
D1095_RS03440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1095_RS03445	COG3100	YcgL domain-containing protein
D1095_RS03450	COG0305	Participates in initiation and elongation during chromosome replication
D1095_RS03455	COG4607	ABC-type enterochelin transport system periplasmic component
D1095_RS03460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1095_RS03465	COG4605	iron ion homeostasis
D1095_RS03470	COG4604	ABC transporter, ATP-binding protein
D1095_RS03475	COG1392	Phosphate transport regulator
D1095_RS03480	COG0306	phosphate transporter
D1095_RS03485	COG4991	sh3 domain protein
D1095_RS03495	COG3945	hemerythrin HHE cation binding domain
D1095_RS03500	COG0343	queuine tRNA-ribosyltransferase activity
D1095_RS03510	COG1278	Cold shock
D1095_RS03515	COG0288	reversible hydration of carbon dioxide
D1095_RS03520	COG0028	Belongs to the TPP enzyme family
D1095_RS03525	COG0440	acetolactate synthase activity
D1095_RS03530	COG0312	modulator of DNA gyrase
D1095_RS03535	COG3028	Belongs to the UPF0307 family
D1095_RS03540	COG3094	Invasion gene expression up-regulator, SirB
D1095_RS03550	COG1811	Na channel or pump
D1095_RS03555	COG3787	Belongs to the UPF0306 family
D1095_RS03560	COG0023	Translation Initiation Factor
D1095_RS03565	COG0284	orotidine-5'-phosphate decarboxylase activity
D1095_RS03570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D1095_RS03575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D1095_RS03580	COG0776	regulation of translation
D1095_RS03585	COG0539	negative regulation of cytoplasmic translation
D1095_RS03595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1095_RS03605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1095_RS03615	COG1785	Belongs to the alkaline phosphatase family
D1095_RS03620	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D1095_RS03630	COG3264	Mechanosensitive ion channel
D1095_RS03630	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1095_RS03635	COG3264	Mechanosensitive ion channel
D1095_RS03635	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1095_RS03640	COG0318	PFAM AMP-dependent synthetase and ligase
D1095_RS03645	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D1095_RS03650	COG0596	Alpha beta hydrolase
D1095_RS03655	COG2226	methyltransferase
D1095_RS03660	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1095_RS03680	COG1380	Effector of murein hydrolase LrgA
D1095_RS03685	COG1346	cytolysis
D1095_RS03690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1095_RS03700	COG3036	rescue of stalled ribosome
D1095_RS03705	COG2226	methyltransferase
D1095_RS03725	COG0658	competence protein
D1095_RS03725	COG2333	competence protein COMEC
D1095_RS03730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D1095_RS03735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1095_RS03740	COG0737	Belongs to the 5'-nucleotidase family
D1095_RS03765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1095_RS03770	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1095_RS03775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1095_RS03785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1095_RS03795	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D1095_RS03800	COG1132	(ABC) transporter
D1095_RS03805	COG1346	cytolysis
D1095_RS03815	COG1199	ATP-dependent helicase activity
D1095_RS03825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1095_RS03830	COG0629	single-stranded DNA binding
D1095_RS03870	COG2070	2-Nitropropane dioxygenase
D1095_RS03880	COG2315	Protein conserved in bacteria
D1095_RS03885	COG4172	Belongs to the ABC transporter superfamily
D1095_RS03890	COG4171	peptide transport system, permease
D1095_RS03895	COG4168	peptide transport system, permease
D1095_RS03900	COG4166	transmembrane transport
D1095_RS03905	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D1095_RS03910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1095_RS03915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1095_RS03920	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D1095_RS03940	COG1368	sulfuric ester hydrolase activity
D1095_RS03945	COG3217	Mosc domain protein beta barrel domain protein
D1095_RS03945	COG0633	Ferredoxin
D1095_RS03950	COG1722	exodeoxyribonuclease VII activity
D1095_RS03955	COG0142	geranyltranstransferase activity
D1095_RS03965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1095_RS03970	COG1530	ribonuclease E activity
D1095_RS03975	COG1944	ATP diphosphatase activity
D1095_RS03980	COG2801	Transposase and inactivated derivatives
D1095_RS03995	COG0500	methyltransferase
D1095_RS04005	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D1095_RS04025	COG2351	hydroxyisourate hydrolase activity
D1095_RS04035	COG0586	Pfam SNARE associated Golgi protein
D1095_RS04040	COG0187	DNA topoisomerase II activity
D1095_RS04045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1095_RS04050	COG1349	DNA-binding transcription factor activity
D1095_RS04055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1095_RS04065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D1095_RS04070	COG4988	ABC transporter
D1095_RS04075	COG2911	Protein conserved in bacteria
D1095_RS04080	COG0729	surface antigen
D1095_RS04085	COG2861	carbohydrate metabolic process
D1095_RS04090	COG4942	peptidase
D1095_RS04095	COG0588	phosphoglycerate mutase activity
D1095_RS04105	COG0572	uridine kinase
D1095_RS04110	COG0717	Belongs to the dCTP deaminase family
D1095_RS04115	COG1309	transcriptional regulator
D1095_RS04120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_RS04125	COG0842	Transport permease protein
D1095_RS04125	COG1129	ABC transporter
D1095_RS04130	COG0842	Transport permease protein
D1095_RS04140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1095_RS04145	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1095_RS04150	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1095_RS04160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1095_RS04165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1095_RS04170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1095_RS04175	COG4166	transmembrane transport
D1095_RS04185	COG0444	Belongs to the ABC transporter superfamily
D1095_RS04190	COG4608	Belongs to the ABC transporter superfamily
D1095_RS04200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1095_RS04210	COG0747	negative chemotaxis
D1095_RS04215	COG0814	amino acid
D1095_RS04220	COG1760	l-serine dehydratase
D1095_RS04225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1095_RS04225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1095_RS04230	COG0134	indole-3-glycerol-phosphate synthase activity
D1095_RS04230	COG0135	phosphoribosylanthranilate isomerase activity
D1095_RS04235	COG3177	Filamentation induced by cAMP protein fic
D1095_RS04240	COG3098	single-species biofilm formation
D1095_RS04245	COG0564	pseudouridine synthase activity
D1095_RS04250	COG3140	Belongs to the UPF0181 family
D1095_RS04260	COG3025	triphosphatase activity
D1095_RS04265	COG3106	COG3106 Predicted ATPase
D1095_RS04270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1095_RS04280	COG1473	amidohydrolase
D1095_RS04285	COG3069	C4-dicarboxylate transmembrane transporter activity
D1095_RS04295	COG0495	leucyl-tRNA aminoacylation
D1095_RS04300	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D1095_RS04305	COG1466	dna polymerase III delta subunit
D1095_RS04310	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1095_RS04315	COG0237	dephospho-CoA kinase activity
D1095_RS04325	COG1459	type II secretion system
D1095_RS04330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1095_RS04335	COG4969	Belongs to the N-Me-Phe pilin family
D1095_RS04340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1095_RS04350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1095_RS04355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1095_RS04360	COG0730	response to heat
D1095_RS04365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1095_RS04370	COG0183	Belongs to the thiolase family
D1095_RS04375	COG1024	Enoyl-CoA hydratase
D1095_RS04375	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1095_RS04390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1095_RS04400	COG0437	4 iron, 4 sulfur cluster binding
D1095_RS04405	COG2864	formate dehydrogenase
D1095_RS04410	COG3058	Necessary for formate dehydrogenase activity
D1095_RS04440	COG1560	Kdo2-lipid A biosynthetic process
D1095_RS04445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1095_RS04455	COG0302	gtp cyclohydrolase
D1095_RS04460	COG3642	lipopolysaccharide core region biosynthetic process
D1095_RS04470	COG0110	maltose O-acetyltransferase activity
D1095_RS04485	COG0583	DNA-binding transcription factor activity
D1095_RS04505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1095_RS04510	COG0215	cysteine-tRNA ligase activity
D1095_RS04515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1095_RS04520	COG0617	tRNA 3'-terminal CCA addition
D1095_RS04545	COG2975	iron-sulfur cluster assembly
D1095_RS04550	COG0633	Ferredoxin
D1095_RS04570	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1095_RS04580	COG0822	iron-sulfur transferase activity
D1095_RS04585	COG1104	cysteine desulfurase activity
D1095_RS04590	COG1959	2 iron, 2 sulfur cluster binding
D1095_RS04600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1095_RS04605	COG0784	Response regulator, receiver
D1095_RS04605	COG5002	protein histidine kinase activity
D1095_RS04605	COG2198	Histidine kinase
D1095_RS04610	COG0697	spore germination
D1095_RS04615	COG2840	Smr protein MutS2
D1095_RS04620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1095_RS04625	COG2226	methyltransferase
D1095_RS04630	COG2830	Protein of unknown function (DUF452)
D1095_RS04635	COG0156	8-amino-7-oxononanoate synthase activity
D1095_RS04640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1095_RS04650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1095_RS04655	COG2027	D-alanyl-D-alanine carboxypeptidase
D1095_RS04670	COG2801	Transposase and inactivated derivatives
D1095_RS04695	COG2856	Zn peptidase
D1095_RS04700	COG3620	sequence-specific DNA binding
D1095_RS04735	COG1444	tRNA N-acetyltransferase activity
D1095_RS04740	COG0138	bifunctional purine biosynthesis protein purh
D1095_RS04765	COG3210	domain, Protein
D1095_RS04770	COG2831	hemolysin activation secretion protein
D1095_RS04775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1095_RS04780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1095_RS04790	COG3078	GTPase activator activity
D1095_RS04795	COG2985	domain, Protein
D1095_RS04795	COG0569	domain protein
D1095_RS04800	COG0786	glutamate:sodium symporter activity
D1095_RS04815	COG2350	Protein conserved in bacteria
D1095_RS04820	COG1607	acyl-coa hydrolase
D1095_RS04835	COG3092	negative regulation of chromosome organization
D1095_RS04840	COG0037	tRNA processing
D1095_RS04845	COG2056	Na+-H+ antiporter family
D1095_RS04850	COG0708	Exodeoxyribonuclease III
D1095_RS04855	COG0583	DNA-binding transcription factor activity
D1095_RS04875	COG0254	rRNA binding
D1095_RS04890	COG0753	catalase activity
D1095_RS04900	COG1408	metallophosphoesterase
D1095_RS04905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1095_RS04910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1095_RS04915	COG1085	galactose-1-phosphate uridylyltransferase
D1095_RS04920	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1095_RS04925	COG2017	converts alpha-aldose to the beta-anomer
D1095_RS04945	COG0489	protein tyrosine kinase activity
D1095_RS04955	COG2095	MarC family integral membrane protein
D1095_RS04960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1095_RS04970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1095_RS04975	COG2354	Protein conserved in bacteria
D1095_RS04980	COG3071	HemY protein
D1095_RS04985	COG2959	enzyme of heme biosynthesis
D1095_RS04995	COG0181	hydroxymethylbilane synthase activity
D1095_RS05000	COG1454	alcohol dehydrogenase
D1095_RS05000	COG1012	belongs to the aldehyde dehydrogenase family
D1095_RS05010	COG4382	Mu-like prophage protein Gp16
D1095_RS05035	COG4396	Host-nuclease inhibitor protein Gam
D1095_RS05045	COG3409	Peptidoglycan-binding domain 1 protein
D1095_RS05045	COG3267	Type II secretory pathway component ExeA
D1095_RS05130	COG4373	Mu-like prophage FluMu protein gp28
D1095_RS05220	COG3392	D12 class N6 adenine-specific DNA methyltransferase
D1095_RS05235	COG0813	purine-nucleoside phosphorylase activity
D1095_RS05245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1095_RS05250	COG2364	Membrane
D1095_RS05255	COG0800	Aldolase
D1095_RS05260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1095_RS05265	COG1904	glucuronate isomerase
D1095_RS05275	COG2186	Transcriptional regulator
D1095_RS05285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1095_RS05285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1095_RS05290	COG1216	Glycosyl transferase, family 2
D1095_RS05295	COG1216	Glycosyl transferase, family 2
D1095_RS05305	COG3306	glycosyltransferase involved in LPS biosynthesis
D1095_RS05315	COG5039	Polysaccharide pyruvyl transferase
D1095_RS05320	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1095_RS05325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1095_RS05330	COG0077	Prephenate dehydratase
D1095_RS05330	COG1605	Chorismate mutase
D1095_RS05335	COG0339	signal peptide processing
D1095_RS05340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1095_RS05345	COG1882	Formate acetyltransferase
D1095_RS05350	COG2116	formate transmembrane transporter activity
D1095_RS05355	COG1238	metal cluster binding
D1095_RS05360	COG0501	Belongs to the peptidase M48B family
D1095_RS05365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1095_RS05370	COG2431	L-lysine efflux transmembrane transporter activity
D1095_RS05375	COG1169	isochorismate synthase
D1095_RS05380	COG0436	Aminotransferase
D1095_RS05390	COG2962	Rard protein
D1095_RS05395	COG1280	lysine exporter protein (LysE YggA)
D1095_RS05400	COG4771	TonB-dependent receptor
D1095_RS05400	COG1629	transport
D1095_RS05405	COG0748	coenzyme F420 binding
D1095_RS05415	COG4235	cytochrome complex assembly
D1095_RS05415	COG3088	subunit of a heme lyase
D1095_RS05420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1095_RS05425	COG1138	Cytochrome C-type biogenesis protein
D1095_RS05430	COG0475	glutathione-regulated potassium exporter activity
D1095_RS05430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1095_RS05440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1095_RS05450	COG3111	PFAM Bacterial OB fold (BOF) protein
D1095_RS05465	COG0745	RESPONSE REGULATOR receiver
D1095_RS05470	COG0642	Histidine kinase
D1095_RS05475	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D1095_RS05480	COG1862	Preprotein translocase
D1095_RS05485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1095_RS05490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1095_RS05495	COG1528	Iron-storage protein
D1095_RS05500	COG1528	Iron-storage protein
D1095_RS05505	COG2252	PERMEase
D1095_RS05510	COG0424	maF-like protein
D1095_RS05520	COG0301	tRNA thio-modification
D1095_RS05520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1095_RS05530	COG0330	HflC and HflK could
D1095_RS05535	COG0330	HflC and HflK could
D1095_RS05540	COG3118	belongs to the thioredoxin family
D1095_RS05560	COG0531	amino acid
D1095_RS05565	COG0531	amino acid
D1095_RS05580	COG3047	cAMP biosynthetic process
D1095_RS05585	COG0542	response to heat
D1095_RS05590	COG0798	PFAM Bile acid sodium symporter
D1095_RS05595	COG1393	Belongs to the ArsC family
D1095_RS05605	COG1027	Aspartate ammonia-lyase
D1095_RS05615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1095_RS05620	COG3064	Membrane
D1095_RS05620	COG3583	domain protein
D1095_RS05620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1095_RS05630	COG0720	synthase
D1095_RS05635	COG0602	queuosine metabolic process
D1095_RS05660	COG0795	lipopolysaccharide-transporting ATPase activity
D1095_RS05665	COG0795	lipopolysaccharide-transporting ATPase activity
D1095_RS05690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D1095_RS05710	COG0861	Integral membrane protein TerC family
D1095_RS05715	COG1472	Belongs to the glycosyl hydrolase 3 family
D1095_RS05725	COG0148	phosphopyruvate hydratase activity
D1095_RS05730	COG1051	belongs to the nudix hydrolase family
D1095_RS05735	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
D1095_RS05745	COG1965	Belongs to the frataxin family
D1095_RS05755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1095_RS05760	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1095_RS05765	COG0564	pseudouridine synthase activity
D1095_RS05775	COG0205	6-phosphofructokinase activity
D1095_RS05780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1095_RS05785	COG1525	nuclease
D1095_RS05790	COG1115	amino acid carrier protein
D1095_RS05795	COG0628	permease
D1095_RS05805	COG0826	peptidase U32
D1095_RS05810	COG3307	-O-antigen
D1095_RS05815	COG1519	Transferase
D1095_RS05820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1095_RS05825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1095_RS05830	COG0802	atpase or kinase
D1095_RS05835	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1095_RS05835	COG1388	LysM domain
D1095_RS05840	COG0166	Belongs to the GPI family
D1095_RS05845	COG2960	long-chain fatty acid transporting porin activity
D1095_RS05870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1095_RS05880	COG0551	DNA topoisomerase type I activity
D1095_RS05890	COG2137	regulation of response to DNA damage stimulus
D1095_RS05895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1095_RS05900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1095_RS05910	COG1322	Protein conserved in bacteria
D1095_RS05915	COG0512	Glutamine amidotransferase of anthranilate synthase
D1095_RS05925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1095_RS05930	COG0494	nUDIX hydrolase
D1095_RS05935	COG0217	transcriptional regulatory protein
D1095_RS05945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1095_RS05950	COG0612	Peptidase, M16
D1095_RS05955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1095_RS05960	COG0471	metal ion transport
D1095_RS05965	COG0583	DNA-binding transcription factor activity
D1095_RS05970	COG3266	domain, Protein
D1095_RS05975	COG1187	pseudouridine synthase activity
D1095_RS05980	COG0009	L-threonylcarbamoyladenylate synthase
D1095_RS05985	COG2837	iron assimilation
D1095_RS05990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1095_RS05995	COG0512	Glutamine amidotransferase of anthranilate synthase
D1095_RS06005	COG2226	methyltransferase
D1095_RS06010	COG2268	Band 7 protein
D1095_RS06015	COG2841	Protein conserved in bacteria
D1095_RS06020	COG0359	binds to the 23S rRNA
D1095_RS06030	COG2965	DNA replication, synthesis of RNA primer
D1095_RS06045	COG3201	nicotinamide mononucleotide transporter
D1095_RS06050	COG2976	Protein conserved in bacteria
D1095_RS06060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1095_RS06065	COG1426	Protein conserved in bacteria
D1095_RS06070	COG0659	secondary active sulfate transmembrane transporter activity
D1095_RS06080	COG0673	inositol 2-dehydrogenase activity
D1095_RS06085	COG0475	glutathione-regulated potassium exporter activity
D1095_RS06085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1095_RS06120	COG1902	pentaerythritol trinitrate reductase activity
D1095_RS06125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1095_RS06130	COG2084	Dehydrogenase
D1095_RS06135	COG0778	Nitroreductase
D1095_RS06140	COG2095	MarC family integral membrane protein
D1095_RS06155	COG0625	glutathione transferase activity
D1095_RS06170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1095_RS06175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1095_RS06190	COG1275	C4-dicarboxylate transporter malic acid transport protein
D1095_RS06195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1095_RS06205	COG1132	(ABC) transporter
D1095_RS06210	COG1854	S-ribosylhomocysteine lyase activity
D1095_RS06215	COG3008	intermembrane lipid transfer
D1095_RS06220	COG0735	belongs to the Fur family
D1095_RS06225	COG0716	FMN binding
D1095_RS06235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1095_RS06240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1095_RS06245	COG2252	PERMEase
D1095_RS06250	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1095_RS06255	COG2081	HI0933 family
D1095_RS06260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1095_RS06270	COG0560	Phosphoserine phosphatase
D1095_RS06275	COG1666	GTP binding
D1095_RS06285	COG0058	SHG alpha-glucan phosphorylase activity
D1095_RS06290	COG2909	trisaccharide binding
D1095_RS06300	COG4580	involved in the transport of maltose and maltodextrins
D1095_RS06305	COG3842	ATPase activity
D1095_RS06320	COG3833	ABC-type maltose transport systems, permease component
D1095_RS06325	COG1640	4-alpha-glucanotransferase
D1095_RS06330	COG1966	Carbon starvation protein
D1095_RS06335	COG0084	hydrolase, TatD family'
D1095_RS06340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1095_RS06350	COG0778	Nitroreductase
D1095_RS06365	COG4172	Belongs to the ABC transporter superfamily
D1095_RS06370	COG0191	fructose-bisphosphate aldolase activity
D1095_RS06375	COG0126	phosphoglycerate kinase activity
D1095_RS06380	COG0471	metal ion transport
D1095_RS06385	COG0471	metal ion transport
D1095_RS06390	COG0471	metal ion transport
D1095_RS06395	COG0187	DNA topoisomerase II activity
D1095_RS06400	COG5002	protein histidine kinase activity
D1095_RS06405	COG0745	RESPONSE REGULATOR receiver
D1095_RS06430	COG0789	Transcriptional regulator
D1095_RS06450	COG0300	oxidoreductase activity
D1095_RS06455	COG0778	Nitroreductase
D1095_RS06460	COG0616	signal peptide processing
D1095_RS06465	COG3719	Belongs to the RNase T2 family
D1095_RS06475	COG1252	NADH dehydrogenase
D1095_RS06480	COG2183	response to ionizing radiation
D1095_RS06485	COG3063	Type IV pilus biogenesis stability protein PilW
D1095_RS06490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1095_RS06520	COG2161	toxin-antitoxin pair type II binding
D1095_RS06525	COG4115	mRNA cleavage
D1095_RS06530	COG2835	tetraacyldisaccharide 4'-kinase activity
D1095_RS06535	COG1663	tetraacyldisaccharide 4'-kinase activity
D1095_RS06540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1095_RS06550	COG2166	iron-sulfur cluster assembly
D1095_RS06570	COG0488	(ABC) transporter
D1095_RS06575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1095_RS06590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1095_RS06595	COG5007	Belongs to the BolA IbaG family
D1095_RS06605	COG2854	intermembrane phospholipid transfer
D1095_RS06610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1095_RS06615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1095_RS06620	COG1127	ABC transporter
D1095_RS06625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1095_RS06630	COG1090	epimerase
D1095_RS06650	COG0563	adenylate kinase activity
D1095_RS06660	COG2814	Major facilitator Superfamily
D1095_RS06690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1095_RS06700	COG1794	racemase activity, acting on amino acids and derivatives
D1095_RS06705	COG2814	Major facilitator Superfamily
D1095_RS06710	COG0363	glucosamine-6-phosphate deaminase activity
D1095_RS06715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1095_RS06720	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1095_RS06725	COG0494	nUDIX hydrolase
D1095_RS06730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1095_RS06735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D1095_RS06740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1095_RS06745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1095_RS06750	COG0549	Belongs to the carbamate kinase family
D1095_RS06765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D1095_RS06770	COG1178	ABC-type Fe3 transport system permease component
D1095_RS06775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_RS06780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1095_RS06785	COG2190	(PTS) system
D1095_RS06795	COG0210	DNA helicase
D1095_RS06800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1095_RS06805	COG0409	Hydrogenase expression formation protein
D1095_RS06810	COG0309	Hydrogenase expression formation protein (HypE)
D1095_RS06835	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D1095_RS06840	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D1095_RS06845	COG0437	4 iron, 4 sulfur cluster binding
D1095_RS06850	COG5557	Pfam Polysulphide reductase, NrfD
D1095_RS06855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D1095_RS06860	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D1095_RS06865	COG1773	rubredoxin
D1095_RS06870	COG0298	carbon dioxide binding
D1095_RS06875	COG0375	protein maturation
D1095_RS06910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1095_RS06915	COG0308	aminopeptidase N
D1095_RS06920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1095_RS06925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1095_RS06930	COG0295	cytidine deaminase activity
D1095_RS06935	COG2177	Part of the ABC transporter FtsEX involved in
D1095_RS06940	COG2884	Cell division ATP-binding protein ftsE
D1095_RS06945	COG0552	protein localization to endoplasmic reticulum
D1095_RS06950	COG0742	ribosomal rna small subunit methyltransferase
D1095_RS06955	COG3099	Belongs to the UPF0263 family
D1095_RS06960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1095_RS06970	COG4160	amino acid transport
D1095_RS06975	COG4215	(ABC) transporter
D1095_RS06980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1095_RS06985	COG1126	abc transporter atp-binding protein
D1095_RS06990	COG1881	PFAM PEBP family protein
D1095_RS07000	COG3620	sequence-specific DNA binding
D1095_RS07010	COG4232	protein-disulfide reductase activity
D1095_RS07015	COG3101	peptidyl-lysine hydroxylation
D1095_RS07025	COG3107	peptidoglycan biosynthetic process
D1095_RS07030	COG0792	nuclease activity
D1095_RS07035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1095_RS07070	COG1138	Cytochrome C-type biogenesis protein
D1095_RS07080	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1095_RS07085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1095_RS07090	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1095_RS07095	COG4133	protoheme IX ABC transporter activity
D1095_RS07100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1095_RS07140	COG3630	sodium ion export across plasma membrane
D1095_RS07150	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D1095_RS07155	COG2824	Alkylphosphonate utilization operon protein PhnA
D1095_RS07160	COG1858	cytochrome C peroxidase
D1095_RS07165	COG1872	DUF167
D1095_RS07170	COG0762	integral membrane protein
D1095_RS07175	COG3171	Protein conserved in bacteria
D1095_RS07180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1095_RS07185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1095_RS07190	COG0416	fatty acid biosynthetic process
D1095_RS07195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1095_RS07200	COG1399	metal-binding, possibly nucleic acid-binding protein
D1095_RS07205	COG4137	Cytochrome C assembly protein
D1095_RS07210	COG4536	flavin adenine dinucleotide binding
D1095_RS07215	COG0733	neurotransmitter:sodium symporter activity
D1095_RS07225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_RS07225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1095_RS07230	COG3715	PTS system
D1095_RS07235	COG3716	PTS system mannose fructose sorbose family IID component
D1095_RS07270	COG1840	ABC-type Fe3 transport system, periplasmic component
D1095_RS07285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1095_RS07300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1095_RS07300	COG0678	peroxiredoxin activity
D1095_RS07305	COG0583	DNA-binding transcription factor activity
D1095_RS07310	COG1309	transcriptional regulator
D1095_RS07315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1095_RS07320	COG0557	exoribonuclease II activity
D1095_RS07330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1095_RS07335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1095_RS07345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1095_RS07395	COG1442	glycosyl transferase family 8
D1095_RS07395	COG1216	Glycosyl transferase, family 2
D1095_RS07405	COG0438	transferase activity, transferring glycosyl groups
D1095_RS07410	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D1095_RS07420	COG1575	Belongs to the MenA family. Type 1 subfamily
D1095_RS07425	COG4804	nuclease activity
D1095_RS07430	COG1720	tRNA m6t6A37 methyltransferase activity
D1095_RS07440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1095_RS07460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1095_RS07465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1095_RS07470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1095_RS07480	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D1095_RS07485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1095_RS07490	COG1755	Isoprenylcysteine carboxyl methyltransferase
D1095_RS07500	COG1530	ribonuclease E activity
D1095_RS07515	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1095_RS07520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1095_RS07530	COG0243	molybdopterin cofactor binding
D1095_RS07535	COG0437	4 iron, 4 sulfur cluster binding
D1095_RS07540	COG0348	domain, Protein
D1095_RS07545	COG3043	anaerobic respiration
D1095_RS07550	COG3005	denitrification pathway
D1095_RS07560	COG2050	protein possibly involved in aromatic compounds catabolism
D1095_RS07565	COG0277	FAD linked oxidase domain protein
D1095_RS07565	COG0247	lactate metabolic process
D1095_RS07570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1095_RS07570	COG2885	chlorophyll binding
D1095_RS07575	COG1879	ABC-type sugar transport system periplasmic component
D1095_RS07580	COG1129	ABC transporter
D1095_RS07585	COG4211	Belongs to the binding-protein-dependent transport system permease family
D1095_RS07610	COG1022	Amp-dependent synthetase and ligase
D1095_RS07615	COG4989	oxidoreductase activity
D1095_RS07620	COG3691	Protein conserved in bacteria
D1095_RS07625	COG0814	amino acid
D1095_RS07645	COG4974	Belongs to the 'phage' integrase family
D1095_RS07650	COG0732	type I restriction modification DNA specificity domain
D1095_RS07675	COG1555	photosystem II stabilization
D1095_RS07680	COG3061	Opacity-associated protein A
D1095_RS07680	COG3266	domain, Protein
D1095_RS07690	COG0859	PFAM glycosyl transferase family 9
D1095_RS07695	COG0859	PFAM glycosyl transferase family 9
D1095_RS07700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1095_RS07705	COG0049	tRNA binding
D1095_RS07710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1095_RS07715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1095_RS07720	COG1045	serine acetyltransferase
D1095_RS07725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1095_RS07735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1095_RS07740	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1095_RS07745	COG1652	LysM domain
D1095_RS07750	COG2927	DNA polymerase III (CHI subunit)
D1095_RS07755	COG2153	protein acetylation
D1095_RS07780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1095_RS07785	COG1803	Methylglyoxal synthase
D1095_RS07790	COG1289	transmembrane transporter activity
D1095_RS07805	COG0783	Belongs to the Dps family
D1095_RS07830	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D1095_RS07835	COG0204	Acyl-transferase
D1095_RS07845	COG0825	malonyl-CoA metabolic process
D1095_RS07865	COG2801	Transposase and inactivated derivatives
D1095_RS07875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1095_RS07900	COG1072	(Pantothenic acid kinase))
D1095_RS07905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1095_RS07920	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1095_RS07930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1095_RS07940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1095_RS07955	COG0625	glutathione transferase activity
D1095_RS07960	COG0019	diaminopimelate decarboxylase activity
D1095_RS07970	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D1095_RS07975	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D1095_RS07980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1095_RS07985	COG1053	succinate dehydrogenase
D1095_RS07990	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D1095_RS08000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1095_RS08005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1095_RS08015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1095_RS08025	COG2264	protein methyltransferase activity
D1095_RS08055	COG4974	Belongs to the 'phage' integrase family
D1095_RS08110	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D1095_RS08125	COG1151	hydroxylamine reductase activity
D1095_RS08130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1095_RS08135	COG2244	polysaccharide biosynthetic process
D1095_RS08140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1095_RS08150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1095_RS08155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D1095_RS08160	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D1095_RS08180	COG0728	peptidoglycan biosynthetic process
D1095_RS08185	COG0268	Binds directly to 16S ribosomal RNA
D1095_RS08190	COG0569	domain protein
D1095_RS08195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1095_RS08200	COG3276	selenocysteine insertion sequence binding
D1095_RS08205	COG1921	L-seryl-tRNASec selenium transferase activity
D1095_RS08215	COG0716	FMN binding
D1095_RS08235	COG1629	transport
D1095_RS08235	COG4771	TonB-dependent receptor
D1095_RS08265	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D1095_RS08305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1095_RS08335	COG1119	ATPase activity
D1095_RS08340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1095_RS08350	COG1739	Uncharacterized protein family UPF0029
D1095_RS08355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1095_RS08360	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D1095_RS08365	COG1970	mechanosensitive ion channel activity
D1095_RS08370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1095_RS08375	COG0321	lipoyl(octanoyl) transferase activity
D1095_RS08380	COG2921	Belongs to the UPF0250 family
D1095_RS08385	COG1686	Belongs to the peptidase S11 family
D1095_RS08390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1095_RS08395	COG0772	Belongs to the SEDS family
D1095_RS08400	COG0768	penicillin binding
D1095_RS08405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1095_RS08410	COG0799	negative regulation of ribosome biogenesis
D1095_RS08420	COG1126	abc transporter atp-binding protein
D1095_RS08430	COG3681	Belongs to the UPF0597 family
D1095_RS08435	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D1095_RS08445	COG3691	Protein conserved in bacteria
D1095_RS08490	COG0832	Belongs to the urease beta subunit family
D1095_RS08495	COG0831	urea catabolic process
D1095_RS08505	COG1122	ATPase activity
D1095_RS08510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D1095_RS08515	COG0310	cobalt ion transport
D1095_RS08520	COG0310	cobalt ion transport
D1095_RS08525	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D1095_RS08530	COG0583	DNA-binding transcription factor activity
D1095_RS08540	COG0490	domain, Protein
D1095_RS08540	COG0471	metal ion transport
D1095_RS08545	COG3722	fumarate hydratase activity
D1095_RS08560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1095_RS08565	COG1349	DNA-binding transcription factor activity
D1095_RS08580	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
D1095_RS08585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1095_RS08590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1095_RS08595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1095_RS08600	COG2900	Belongs to the SlyX family
D1095_RS08605	COG0545	Peptidyl-prolyl cis-trans isomerase
D1095_RS08610	COG2964	Protein conserved in bacteria
D1095_RS08615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1095_RS08625	COG2168	tRNA wobble position uridine thiolation
D1095_RS08660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1095_RS08665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1095_RS08670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1095_RS08675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1095_RS08700	COG0357	Ribosomal RNA small subunit methyltransferase G
D1095_RS08705	COG0445	tRNA wobble uridine modification
D1095_RS08710	COG0561	phosphatase activity
D1095_RS08715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1095_RS08720	COG3012	SEC-C Motif Domain Protein
D1095_RS08730	COG3716	PTS system mannose fructose sorbose family IID component
D1095_RS08735	COG3715	PTS system
D1095_RS08740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_RS08740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1095_RS08745	COG2610	gluconate transmembrane transporter activity
D1095_RS08750	COG3265	gluconokinase activity
D1095_RS08755	COG1609	Transcriptional regulator
D1095_RS08760	COG1609	Transcriptional regulator
D1095_RS08765	COG1869	D-ribose catabolic process
D1095_RS08775	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1095_RS08780	COG1879	ABC-type sugar transport system periplasmic component
D1095_RS08785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1095_RS08790	COG0243	molybdopterin cofactor binding
D1095_RS08795	COG0437	4 iron, 4 sulfur cluster binding
D1095_RS08800	COG3302	dmso reductase anchor subunit
D1095_RS08805	COG3381	protein complex oligomerization
D1095_RS08810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1095_RS08810	COG2221	Nitrite and sulphite reductase 4Fe-4S
D1095_RS08835	COG1349	DNA-binding transcription factor activity
D1095_RS08840	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
D1095_RS08845	COG1070	Carbohydrate kinase
D1095_RS08850	COG4154	Belongs to the RbsD FucU family
D1095_RS08855	COG0235	Class ii aldolase
D1095_RS08860	COG0738	Major facilitator superfamily
D1095_RS08865	COG1454	alcohol dehydrogenase
D1095_RS08870	COG3477	response to acidic pH
D1095_RS08875	COG0765	amino acid transport
D1095_RS08885	COG1126	abc transporter atp-binding protein
D1095_RS08890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1095_RS08910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D1095_RS08935	COG3623	hexulose-6-phosphate isomerase
D1095_RS08940	COG0235	Class ii aldolase
D1095_RS08945	COG0545	Peptidyl-prolyl cis-trans isomerase
D1095_RS08970	COG4783	chaperone-mediated protein folding
D1095_RS08975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1095_RS08985	COG0758	DNA mediated transformation
D1095_RS08990	COG1297	OPT oligopeptide transporter protein
D1095_RS09005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1095_RS09015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1095_RS09020	COG0081	regulation of translation
D1095_RS09025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1095_RS09030	COG0222	ribosome binding
D1095_RS09075	COG0827	DNA restriction-modification system
D1095_RS09095	COG1487	ribonuclease activity
D1095_RS09115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D1095_RS09120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1095_RS09130	COG0346	lactoylglutathione lyase activity
D1095_RS09135	COG1194	a g-specific adenine glycosylase
D1095_RS09140	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D1095_RS09145	COG0741	lytic transglycosylase activity
D1095_RS09175	COG0305	Participates in initiation and elongation during chromosome replication
D1095_RS09230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1095_RS09245	COG0737	Belongs to the 5'-nucleotidase family
D1095_RS09250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1095_RS09255	COG0606	chelatase, subunit chli
D1095_RS09265	COG2267	carboxylic ester hydrolase activity
D1095_RS09270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D1095_RS09280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D1095_RS09290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1095_RS09300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1095_RS09320	COG0051	transcription antitermination factor activity, RNA binding
D1095_RS09325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1095_RS09330	COG0088	Forms part of the polypeptide exit tunnel
D1095_RS09335	COG0089	rRNA binding
D1095_RS09340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1095_RS09345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1095_RS09350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1095_RS09355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1095_RS09360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1095_RS09365	COG0255	Belongs to the universal ribosomal protein uL29 family
D1095_RS09370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1095_RS09380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1095_RS09385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1095_RS09390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1095_RS09395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1095_RS09400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1095_RS09405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1095_RS09410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1095_RS09415	COG1841	ribosomal large subunit assembly
D1095_RS09420	COG0200	Binds to the 23S rRNA
D1095_RS09425	COG0201	protein transport
D1095_RS09435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1095_RS09440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1095_RS09445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1095_RS09450	COG0202	RNA polymerase activity
D1095_RS09460	COG0228	four-way junction DNA binding
D1095_RS09465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1095_RS09470	COG0336	Belongs to the RNA methyltransferase TrmD family
D1095_RS09475	COG0335	large ribosomal subunit rRNA binding
D1095_RS09480	COG2850	peptidyl-arginine hydroxylation
D1095_RS09485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1095_RS09490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1095_RS09535	COG2852	Protein conserved in bacteria
D1095_RS09560	COG2832	Protein of unknown function (DUF454)
D1095_RS09570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1095_RS09580	COG0084	hydrolase, TatD family'
D1095_RS09595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_RS09605	COG0470	DNA polymerase III
D1095_RS09610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1095_RS09615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1095_RS09630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1095_RS09635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1095_RS09640	COG0254	rRNA binding
D1095_RS09645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1095_RS09650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1095_RS09655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1095_RS09660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1095_RS09670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1095_RS09685	COG0442	prolyl-tRNA aminoacylation
D1095_RS09695	COG1595	DNA-templated transcription, initiation
D1095_RS09700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1095_RS09710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1095_RS09735	COG2502	aspartate--ammonia ligase
D1095_RS09740	COG1522	sequence-specific DNA binding
D1095_RS09745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D1095_RS09750	COG3161	chorismate lyase activity
D1095_RS09785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1095_RS09810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D1095_RS09820	COG4208	sulfate ABC transporter
D1095_RS09825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1095_RS09830	COG1304	FMN binding
D1095_RS09840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1095_RS09850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1095_RS09855	COG2995	paraquat-inducible protein a
D1095_RS09860	COG1305	Transglutaminase-like
D1095_RS09870	COG2608	mercury ion transmembrane transporter activity
D1095_RS09875	COG1979	alcohol dehydrogenase
D1095_RS09880	COG0583	DNA-binding transcription factor activity
D1095_RS09885	COG2171	N-acyltransferase activity
D1095_RS09890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1095_RS09900	COG0511	ligase activity, forming carbon-carbon bonds
D1095_RS09905	COG0439	Biotin carboxylase
D1095_RS09915	COG3084	Protein conserved in bacteria
D1095_RS09920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1095_RS09925	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1095_RS09925	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1095_RS09935	COG1876	peptidase activity
D1095_RS09940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1095_RS09945	COG1393	Belongs to the ArsC family
D1095_RS09955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1095_RS09960	COG0564	pseudouridine synthase activity
D1095_RS09970	COG0668	transmembrane transport
D1095_RS09975	COG0439	Biotin carboxylase
D1095_RS09985	COG1025	Belongs to the peptidase M16 family
D1095_RS09990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D1095_RS10015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1095_RS10020	COG1067	ATP-dependent peptidase activity
D1095_RS10025	COG3120	sequence-specific DNA binding
D1095_RS10030	COG0180	Tryptophanyl-tRNA synthetase
D1095_RS10055	COG0730	response to heat
D1095_RS10070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1095_RS10080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1095_RS10085	COG2116	formate transmembrane transporter activity
D1095_RS10110	COG0443	Heat shock 70 kDa protein
D1095_RS10115	COG1070	Carbohydrate kinase
D1095_RS10120	COG2115	Belongs to the xylose isomerase family
D1095_RS10125	COG4213	ABC transporter substrate-binding protein
D1095_RS10130	COG1129	ABC transporter
D1095_RS10135	COG4214	carbohydrate transport
D1095_RS10140	COG1609	Transcriptional regulator
D1095_RS10140	COG2207	Transcriptional regulator
D1095_RS10145	COG3590	peptidase
D1095_RS10155	COG4145	pantothenate transmembrane transporter activity
D1095_RS10160	COG3924	membrane
D1095_RS10165	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D1095_RS10170	COG2853	Lipoprotein
D1095_RS10175	COG0676	glucose-6-phosphate 1-epimerase activity
D1095_RS10190	COG0726	polysaccharide deacetylase
D1095_RS10190	COG1649	PFAM Uncharacterised BCR, COG1649
D1095_RS10195	COG1215	transferase activity, transferring glycosyl groups
D1095_RS10205	COG0149	triose-phosphate isomerase activity
D1095_RS10215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1095_RS10220	COG1238	metal cluster binding
D1095_RS10235	COG1388	LysM domain
D1095_RS10235	COG4942	peptidase
D1095_RS10240	COG2818	Glycosylase
D1095_RS10250	COG0700	Nucleoside recognition
D1095_RS10255	COG3366	ferrous iron transmembrane transporter activity
D1095_RS10265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1095_RS10270	COG0594	ribonuclease P activity
D1095_RS10275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1095_RS10280	COG0174	glutamine synthetase
D1095_RS10285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1095_RS10290	COG0494	nUDIX hydrolase
D1095_RS10320	COG1490	D-aminoacyl-tRNA deacylase activity
D1095_RS10325	COG1295	ribonuclease BN
D1095_RS10330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1095_RS10335	COG1629	transport
D1095_RS10335	COG4771	TonB-dependent receptor
D1095_RS10345	COG1629	transport
D1095_RS10345	COG4771	TonB-dependent receptor
D1095_RS10365	COG1064	alcohol dehydrogenase
D1095_RS10375	COG1923	regulation of RNA biosynthetic process
D1095_RS10380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1095_RS10385	COG1611	Belongs to the LOG family
D1095_RS10390	COG1694	Mazg nucleotide pyrophosphohydrolase
D1095_RS10405	COG1309	transcriptional regulator
D1095_RS10415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1095_RS10420	COG2003	Belongs to the UPF0758 family
D1095_RS10425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1095_RS10430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1095_RS10440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1095_RS10445	COG0076	glutamate decarboxylase activity
D1095_RS10450	COG0425	Belongs to the sulfur carrier protein TusA family
D1095_RS10455	COG2391	methyltransferase activity
D1095_RS10460	COG3085	chromosome segregation
D1095_RS10480	COG0598	Magnesium transport protein CorA
D1095_RS10485	COG2226	methyltransferase
D1095_RS10500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1095_RS10505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1095_RS10510	COG0805	protein transport
D1095_RS10530	COG1114	Component of the transport system for branched-chain amino acids
D1095_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
D1095_RS10540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1095_RS10545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1095_RS10550	COG0142	geranyltranstransferase activity
D1095_RS10560	COG0431	NADPH-dependent FMN reductase
D1095_RS10565	COG2259	Doxx family
D1095_RS10570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1095_RS10575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1095_RS10580	COG0697	spore germination
D1095_RS10585	COG4783	chaperone-mediated protein folding
D1095_RS10595	COG1040	competence protein
D1095_RS10600	COG2813	Specifically methylates the guanine in position
D1095_RS10610	COG0456	acetyltransferase
D1095_RS10615	COG0513	Belongs to the DEAD box helicase family
D1095_RS10625	COG0747	negative chemotaxis
D1095_RS10635	COG1584	GPR1 FUN34 yaaH family protein
D1095_RS10640	COG1120	ATPase activity
D1095_RS10645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1095_RS10650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1095_RS10675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1095_RS10680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1095_RS10705	COG4804	nuclease activity
D1095_RS10710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1095_RS10730	COG0140	phosphoribosyl-ATP diphosphatase activity
D1095_RS10730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1095_RS10735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D1095_RS10740	COG0024	Methionine aminopeptidase
D1095_RS10755	COG1621	beta-fructofuranosidase activity
D1095_RS10760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1095_RS10770	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1095_RS10775	COG1136	(ABC) transporter
D1095_RS10780	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1095_RS10785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family