locus-tag	class	description
APJL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APJL_RS00010	COG0592	DNA-directed DNA polymerase activity
APJL_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APJL_RS00040	COG0616	signal peptide processing
APJL_RS00055	COG3116	cell division
APJL_RS00060	COG0768	penicillin binding
APJL_RS00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APJL_RS00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APJL_RS00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APJL_RS00085	COG0772	Belongs to the SEDS family
APJL_RS00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APJL_RS00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
APJL_RS00110	COG0849	cell division
APJL_RS00125	COG0497	DNA recombination
APJL_RS00130	COG4172	Belongs to the ABC transporter superfamily
APJL_RS00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APJL_RS00140	COG0601	transmembrane transport
APJL_RS00170	COG0012	GTP binding
APJL_RS00175	COG2020	methyltransferase activity
APJL_RS00185	COG3133	Outer membrane lipoprotein
APJL_RS00190	COG3102	Protein conserved in bacteria
APJL_RS00195	COG0018	arginyl-trna synthetase
APJL_RS00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APJL_RS00215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APJL_RS00220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APJL_RS00225	COG0196	riboflavin kinase activity
APJL_RS00230	COG3172	ATPase kinase involved in NAD metabolism
APJL_RS00235	COG2129	metallophosphoesterase
APJL_RS00240	COG0745	RESPONSE REGULATOR receiver
APJL_RS00250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APJL_RS00255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APJL_RS00260	COG1217	gtp-binding protein TYPA
APJL_RS00265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APJL_RS00270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APJL_RS00275	COG1561	YicC-like family, N-terminal region
APJL_RS00280	COG0354	folic acid binding
APJL_RS00285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APJL_RS00290	COG2197	response regulator
APJL_RS00300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APJL_RS00335	COG0747	negative chemotaxis
APJL_RS00340	COG0747	negative chemotaxis
APJL_RS00345	COG0601	transmembrane transport
APJL_RS00350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APJL_RS00355	COG0444	Belongs to the ABC transporter superfamily
APJL_RS00360	COG4608	Belongs to the ABC transporter superfamily
APJL_RS00375	COG0251	oxidation-reduction process
APJL_RS00380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APJL_RS00385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APJL_RS00390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APJL_RS00395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APJL_RS00400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APJL_RS00405	COG0848	biopolymer transport protein
APJL_RS00410	COG0811	peptide transport
APJL_RS00420	COG3118	belongs to the thioredoxin family
APJL_RS00425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APJL_RS00425	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APJL_RS00425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APJL_RS00430	COG1461	Dihydroxyacetone kinase
APJL_RS00435	COG2376	Dihydroxyacetone kinase
APJL_RS00440	COG0492	ferredoxin-NADP+ reductase activity
APJL_RS00450	COG3753	Protein conserved in bacteria
APJL_RS00470	COG3030	protein affecting phage T7 exclusion by the F plasmid
APJL_RS00475	COG0006	proline dipeptidase activity
APJL_RS00485	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
APJL_RS00510	COG3978	acetolactate synthase activity
APJL_RS00525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APJL_RS00530	COG0437	4 iron, 4 sulfur cluster binding
APJL_RS00535	COG3301	Polysulphide reductase, NrfD
APJL_RS00560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APJL_RS00565	COG1414	Transcriptional regulator
APJL_RS00570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APJL_RS00590	COG3068	Protein conserved in bacteria
APJL_RS00615	COG1278	Cold shock
APJL_RS00620	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
APJL_RS00625	COG0793	Belongs to the peptidase S41A family
APJL_RS00630	COG2989	Protein conserved in bacteria
APJL_RS00635	COG3108	Peptidase M15
APJL_RS00640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APJL_RS00655	COG0537	adenosine 5'-monophosphoramidase activity
APJL_RS00660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APJL_RS00665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APJL_RS00675	COG1162	GTPase activity
APJL_RS00680	COG0583	DNA-binding transcription factor activity
APJL_RS00685	COG1011	Hydrolase
APJL_RS00690	COG0583	DNA-binding transcription factor activity
APJL_RS00700	COG0252	asparaginase activity
APJL_RS00710	COG5413	integral membrane protein
APJL_RS00725	COG3835	regulator
APJL_RS00730	COG2610	gluconate transmembrane transporter activity
APJL_RS00735	COG1929	Belongs to the glycerate kinase type-1 family
APJL_RS00740	COG1254	Belongs to the acylphosphatase family
APJL_RS00745	COG3593	DNA synthesis involved in DNA repair
APJL_RS00750	COG1611	Belongs to the LOG family
APJL_RS00755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APJL_RS00765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APJL_RS00770	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APJL_RS00770	COG0316	Belongs to the HesB IscA family
APJL_RS00780	COG1805	sodium ion transport
APJL_RS00785	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APJL_RS00790	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APJL_RS00795	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APJL_RS00800	COG2871	sodium ion transport
APJL_RS00805	COG1477	protein flavinylation
APJL_RS00810	COG2991	Protein conserved in bacteria
APJL_RS00820	COG2814	Major facilitator Superfamily
APJL_RS00825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APJL_RS00835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APJL_RS00850	COG4657	Part of a membrane complex involved in electron transport
APJL_RS00855	COG2878	Part of a membrane complex involved in electron transport
APJL_RS00860	COG4656	Part of a membrane complex involved in electron transport
APJL_RS00885	COG1560	Kdo2-lipid A biosynthetic process
APJL_RS00890	COG0402	S-adenosylhomocysteine deaminase activity
APJL_RS00895	COG4143	(ABC) transporter
APJL_RS00900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APJL_RS00905	COG0617	tRNA 3'-terminal CCA addition
APJL_RS00910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APJL_RS00920	COG2911	Protein conserved in bacteria
APJL_RS00930	COG0346	lactoylglutathione lyase activity
APJL_RS00935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APJL_RS00945	COG1605	Chorismate mutase
APJL_RS00945	COG0287	Prephenate dehydrogenase
APJL_RS00950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APJL_RS00955	COG0859	PFAM glycosyl transferase family 9
APJL_RS00960	COG0469	pyruvate kinase activity
APJL_RS00965	COG2062	phosphohistidine phosphatase, SixA
APJL_RS00970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APJL_RS00975	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APJL_RS00980	COG0733	neurotransmitter:sodium symporter activity
APJL_RS00985	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APJL_RS00990	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APJL_RS00995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APJL_RS01000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APJL_RS01005	COG4972	Pilus assembly protein
APJL_RS01025	COG4796	Type ii and iii secretion system protein
APJL_RS01030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APJL_RS01035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APJL_RS01040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APJL_RS01045	COG1280	lysine exporter protein (LysE YggA)
APJL_RS01050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APJL_RS01060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APJL_RS01065	COG2801	Transposase and inactivated derivatives
APJL_RS01070	COG2963	transposase activity
APJL_RS01075	COG2963	transposase activity
APJL_RS01085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APJL_RS01140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APJL_RS01145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APJL_RS01150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APJL_RS01165	COG2963	transposase activity
APJL_RS01170	COG2801	Transposase and inactivated derivatives
APJL_RS01175	COG2801	Transposase and inactivated derivatives
APJL_RS01180	COG1253	flavin adenine dinucleotide binding
APJL_RS01185	COG0564	pseudouridine synthase activity
APJL_RS01190	COG0406	alpha-ribazole phosphatase activity
APJL_RS01195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APJL_RS01200	COG1678	Uncharacterized ACR, COG1678
APJL_RS01205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APJL_RS01215	COG0271	Belongs to the BolA IbaG family
APJL_RS01240	COG0653	protein targeting
APJL_RS01250	COG0494	nUDIX hydrolase
APJL_RS01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APJL_RS01265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APJL_RS01275	COG1629	transport
APJL_RS01275	COG4771	TonB-dependent receptor
APJL_RS01285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APJL_RS01290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APJL_RS01295	COG0083	homoserine kinase activity
APJL_RS01305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APJL_RS01310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APJL_RS01315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APJL_RS01345	COG2195	Cleaves the N-terminal amino acid of tripeptides
APJL_RS01350	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APJL_RS01355	COG0194	GDP metabolic process
APJL_RS01360	COG1538	Outer membrane efflux protein
APJL_RS01365	COG2914	Belongs to the UPF0125 (RnfH) family
APJL_RS01370	COG2867	negative regulation of translational initiation
APJL_RS01375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APJL_RS01380	COG4149	molybdate abc transporter
APJL_RS01385	COG0725	ABC transporter, periplasmic molybdate-binding protein
APJL_RS01390	COG0842	Transport permease protein
APJL_RS01395	COG1131	(ABC) transporter
APJL_RS01400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APJL_RS01405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APJL_RS01420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APJL_RS01425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APJL_RS01430	COG1121	(ABC) transporter
APJL_RS01440	COG2920	part of a sulfur-relay system
APJL_RS01445	COG0670	Belongs to the BI1 family
APJL_RS01450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APJL_RS01465	COG0084	hydrolase, TatD family'
APJL_RS01470	COG0210	DNA helicase
APJL_RS01475	COG3842	ATPase activity
APJL_RS01480	COG1176	ABC-type spermidine putrescine transport system, permease component I
APJL_RS01485	COG1177	transmembrane transport
APJL_RS01495	COG2255	four-way junction helicase activity
APJL_RS01500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APJL_RS01505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APJL_RS01540	COG0488	(ABC) transporter
APJL_RS01545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APJL_RS01555	COG1271	oxidase subunit
APJL_RS01560	COG1294	oxidase, subunit
APJL_RS01570	COG0824	Thioesterase
APJL_RS01575	COG0811	peptide transport
APJL_RS01580	COG0848	biopolymer transport protein
APJL_RS01585	COG3064	Membrane
APJL_RS01585	COG3064	Membrane
APJL_RS01590	COG0823	Involved in the tonB-independent uptake of proteins
APJL_RS01605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APJL_RS01610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APJL_RS01620	COG0488	(ABC) transporter
APJL_RS01635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APJL_RS01645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APJL_RS01650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APJL_RS01660	COG0564	pseudouridine synthase activity
APJL_RS01665	COG3023	N-Acetylmuramoyl-L-alanine amidase
APJL_RS01670	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APJL_RS01675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APJL_RS01680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APJL_RS01685	COG0626	cystathionine gamma-synthase activity
APJL_RS01690	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APJL_RS01705	COG1702	phosphate starvation-inducible protein PhoH
APJL_RS01715	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APJL_RS01720	COG0709	Synthesizes selenophosphate from selenide and ATP
APJL_RS01730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APJL_RS01750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APJL_RS01755	COG1660	Displays ATPase and GTPase activities
APJL_RS01760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APJL_RS01765	COG1137	ATPase activity
APJL_RS01770	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APJL_RS01780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APJL_RS01785	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APJL_RS01795	COG1704	LemA family
APJL_RS01800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APJL_RS01800	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APJL_RS01800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APJL_RS01805	COG1105	Belongs to the carbohydrate kinase PfkB family
APJL_RS01810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APJL_RS01810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APJL_RS01820	COG1523	belongs to the glycosyl hydrolase 13 family
APJL_RS01825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APJL_RS01830	COG0297	glycogen (starch) synthase activity
APJL_RS01835	COG0058	SHG alpha-glucan phosphorylase activity
APJL_RS01855	COG1187	pseudouridine synthase activity
APJL_RS01860	COG2814	Major facilitator Superfamily
APJL_RS01870	COG3381	protein complex oligomerization
APJL_RS01880	COG0791	NLP P60 protein
APJL_RS01885	COG2932	Transcriptional regulator
APJL_RS01890	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
APJL_RS01895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APJL_RS01900	COG2990	Protein conserved in bacteria
APJL_RS01910	COG1643	Atp-dependent helicase
APJL_RS01915	COG2707	UPF0756 membrane protein
APJL_RS01925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APJL_RS01930	COG0534	Mate efflux family protein
APJL_RS01935	COG1074	ATP-dependent DNA helicase activity
APJL_RS01940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APJL_RS01945	COG4535	Mg2 and Co2 transporter CorC
APJL_RS01955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APJL_RS01960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APJL_RS01965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APJL_RS01980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APJL_RS01985	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
APJL_RS01990	COG0247	lactate metabolic process
APJL_RS02025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APJL_RS02025	COG0517	IMP dehydrogenase activity
APJL_RS02035	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APJL_RS02040	COG0385	Bile acid
APJL_RS02045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APJL_RS02050	COG0561	phosphatase activity
APJL_RS02060	COG1595	DNA-templated transcription, initiation
APJL_RS02065	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APJL_RS02075	COG0318	PFAM AMP-dependent synthetase and ligase
APJL_RS02080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APJL_RS02090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APJL_RS02095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APJL_RS02100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APJL_RS02100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APJL_RS02135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APJL_RS02140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APJL_RS02155	COG0750	zinc metalloprotease
APJL_RS02160	COG0575	Belongs to the CDS family
APJL_RS02165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APJL_RS02180	COG0671	phosphoesterase, PA-phosphatase related
APJL_RS02185	COG1534	Rna-binding protein
APJL_RS02190	COG0463	Glycosyl transferase, family 2
APJL_RS02200	COG0859	PFAM glycosyl transferase family 9
APJL_RS02210	COG0328	RNA-DNA hybrid ribonuclease activity
APJL_RS02215	COG1286	toxin biosynthetic process
APJL_RS02220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APJL_RS02230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APJL_RS02235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APJL_RS02245	COG0251	oxidation-reduction process
APJL_RS02250	COG1496	oxidoreductase activity
APJL_RS02260	COG5645	(Lipo)protein
APJL_RS02275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APJL_RS02285	COG1792	Involved in formation and maintenance of cell shape
APJL_RS02290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APJL_RS02295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APJL_RS02300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APJL_RS02305	COG0121	glutamine amidotransferase
APJL_RS02310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APJL_RS02315	COG2949	membrane
APJL_RS02325	COG1556	Lactate utilization protein
APJL_RS02330	COG1139	Iron-sulfur cluster binding protein
APJL_RS02335	COG0247	lactate metabolic process
APJL_RS02340	COG1620	l-lactate permease
APJL_RS02345	COG2916	Histone family protein nucleoid-structuring protein H-NS
APJL_RS02350	COG1757	Na H antiporter
APJL_RS02355	COG1879	ABC-type sugar transport system periplasmic component
APJL_RS02360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APJL_RS02370	COG2990	Protein conserved in bacteria
APJL_RS02375	COG0508	dehydrogenase complex catalyzes the overall conversion of
APJL_RS02380	COG0567	Dehydrogenase, E1 component
APJL_RS02385	COG1121	(ABC) transporter
APJL_RS02390	COG0739	heme binding
APJL_RS02395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APJL_RS02400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APJL_RS02410	COG0561	phosphatase activity
APJL_RS02415	COG3850	Histidine kinase
APJL_RS02425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APJL_RS02435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APJL_RS02445	COG4221	oxidoreductase activity
APJL_RS02470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APJL_RS02470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APJL_RS02490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APJL_RS02495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APJL_RS02520	COG0640	Transcriptional regulator
APJL_RS02530	COG0189	ligase activity
APJL_RS02535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APJL_RS02550	COG3683	transport system, periplasmic component
APJL_RS02555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APJL_RS02560	COG1115	amino acid carrier protein
APJL_RS02570	COG1116	anion transmembrane transporter activity
APJL_RS02580	COG2104	thiamine diphosphate biosynthetic process
APJL_RS02590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APJL_RS02595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APJL_RS02605	COG0351	phosphomethylpyrimidine kinase
APJL_RS02615	COG0481	GTPase activity
APJL_RS02620	COG0681	Belongs to the peptidase S26 family
APJL_RS02695	COG0433	COG0433 Predicted ATPase
APJL_RS02700	COG1840	ABC-type Fe3 transport system, periplasmic component
APJL_RS02720	COG4178	(ABC) transporter
APJL_RS02735	COG2194	sulfuric ester hydrolase activity
APJL_RS02740	COG0528	UMP kinase activity
APJL_RS02745	COG0233	cytoplasmic translational termination
APJL_RS02750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APJL_RS02765	COG0590	tRNA wobble adenosine to inosine editing
APJL_RS02770	COG0513	Belongs to the DEAD box helicase family
APJL_RS02775	COG4785	May be involved in cell division
APJL_RS02785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APJL_RS02795	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APJL_RS02810	COG3083	sulfuric ester hydrolase activity
APJL_RS02820	COG1309	transcriptional regulator
APJL_RS02825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APJL_RS02830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APJL_RS02845	COG3955	Domain of unknown function (DUF1919)
APJL_RS02850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APJL_RS02865	COG0517	IMP dehydrogenase activity
APJL_RS02865	COG0516	GMP reductase activity
APJL_RS02870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APJL_RS02875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APJL_RS02880	COG0814	amino acid
APJL_RS02885	COG0814	amino acid
APJL_RS02895	COG3105	Protein conserved in bacteria
APJL_RS02900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APJL_RS02925	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
APJL_RS02930	COG1823	symporter activity
APJL_RS02935	COG0778	Nitroreductase
APJL_RS02945	COG0072	phenylalanine-tRNA ligase activity
APJL_RS02950	COG0776	regulation of translation
APJL_RS02955	COG0791	NLP P60 protein
APJL_RS02960	COG2801	Transposase and inactivated derivatives
APJL_RS02965	COG2801	Transposase and inactivated derivatives
APJL_RS02970	COG2963	transposase activity
APJL_RS02975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APJL_RS02980	COG1846	Transcriptional regulator
APJL_RS02980	COG1940	carbohydrate kinase activity
APJL_RS02985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APJL_RS02990	COG1522	sequence-specific DNA binding
APJL_RS02995	COG1674	ftsk spoiiie
APJL_RS03000	COG2321	neutral zinc metallopeptidase
APJL_RS03005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APJL_RS03010	COG1214	PFAM Peptidase M22, glycoprotease
APJL_RS03015	COG1435	thymidine kinase activity
APJL_RS03020	COG3074	FtsZ-dependent cytokinesis
APJL_RS03025	COG1494	fructose-1,6-bisphosphatase
APJL_RS03030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APJL_RS03035	COG1136	(ABC) transporter
APJL_RS03035	COG0577	efflux transmembrane transporter activity
APJL_RS03040	COG2205	protein histidine kinase activity
APJL_RS03045	COG0745	RESPONSE REGULATOR receiver
APJL_RS03050	COG3956	TIGRFAM MazG family protein
APJL_RS03060	COG0285	dihydrofolate synthase activity
APJL_RS03070	COG0779	Required for maturation of 30S ribosomal subunits
APJL_RS03075	COG0195	Participates in both transcription termination and antitermination
APJL_RS03085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APJL_RS03090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APJL_RS03095	COG2951	lytic endotransglycosylase activity
APJL_RS03105	COG0280	phosphate acetyltransferase
APJL_RS03105	COG0857	belongs to the CobB CobQ family
APJL_RS03115	COG0737	Belongs to the 5'-nucleotidase family
APJL_RS03135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APJL_RS03145	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APJL_RS03155	COG0589	response to stress
APJL_RS03165	COG2969	positive regulation of protein catabolic process
APJL_RS03170	COG0625	glutathione transferase activity
APJL_RS03175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APJL_RS03185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APJL_RS03190	COG1448	Aminotransferase
APJL_RS03195	COG0006	proline dipeptidase activity
APJL_RS03225	COG1487	ribonuclease activity
APJL_RS03240	COG0556	nucleotide-excision repair
APJL_RS03245	COG2822	iron ion transport
APJL_RS03250	COG2837	iron assimilation
APJL_RS03260	COG0613	PHP domain protein
APJL_RS03270	COG2925	Exonuclease
APJL_RS03275	COG0038	chloride channel
APJL_RS03285	COG1509	lysine 2,3-aminomutase activity
APJL_RS03295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APJL_RS03300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APJL_RS03305	COG2814	Major facilitator Superfamily
APJL_RS03310	COG0741	lytic transglycosylase activity
APJL_RS03315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APJL_RS03320	COG0626	cystathionine gamma-synthase activity
APJL_RS03345	COG2363	Small membrane protein
APJL_RS03350	COG0277	FAD linked oxidase domain protein
APJL_RS03355	COG0243	molybdopterin cofactor binding
APJL_RS03360	COG3005	denitrification pathway
APJL_RS03370	COG0315	cyclic pyranopterin monophosphate synthase activity
APJL_RS03375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APJL_RS03380	COG0314	molybdopterin synthase activity
APJL_RS03385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APJL_RS03390	COG1444	tRNA N-acetyltransferase activity
APJL_RS03400	COG0583	DNA-binding transcription factor activity
APJL_RS03425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APJL_RS03445	COG1737	Transcriptional regulator
APJL_RS03450	COG2731	YhcH YjgK YiaL family protein
APJL_RS03455	COG0248	Ppx GppA phosphatase
APJL_RS03460	COG2926	Belongs to the UPF0265 family
APJL_RS03475	COG3100	YcgL domain-containing protein
APJL_RS03480	COG0305	Participates in initiation and elongation during chromosome replication
APJL_RS03485	COG4607	ABC-type enterochelin transport system periplasmic component
APJL_RS03490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APJL_RS03495	COG4605	iron ion homeostasis
APJL_RS03500	COG4604	ABC transporter, ATP-binding protein
APJL_RS03505	COG1392	Phosphate transport regulator
APJL_RS03510	COG0306	phosphate transporter
APJL_RS03515	COG4991	sh3 domain protein
APJL_RS03525	COG3945	hemerythrin HHE cation binding domain
APJL_RS03540	COG1278	Cold shock
APJL_RS03550	COG0028	Belongs to the TPP enzyme family
APJL_RS03555	COG0440	acetolactate synthase activity
APJL_RS03560	COG0312	modulator of DNA gyrase
APJL_RS03565	COG3028	Belongs to the UPF0307 family
APJL_RS03570	COG3094	Invasion gene expression up-regulator, SirB
APJL_RS03580	COG1811	Na channel or pump
APJL_RS03585	COG3787	Belongs to the UPF0306 family
APJL_RS03590	COG0023	Translation Initiation Factor
APJL_RS03595	COG0284	orotidine-5'-phosphate decarboxylase activity
APJL_RS03600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APJL_RS03605	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APJL_RS03610	COG0776	regulation of translation
APJL_RS03615	COG0539	negative regulation of cytoplasmic translation
APJL_RS03635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APJL_RS03645	COG1785	Belongs to the alkaline phosphatase family
APJL_RS03650	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
APJL_RS03660	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APJL_RS03660	COG3264	Mechanosensitive ion channel
APJL_RS03665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APJL_RS03665	COG3264	Mechanosensitive ion channel
APJL_RS03670	COG0318	PFAM AMP-dependent synthetase and ligase
APJL_RS03675	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APJL_RS03680	COG0596	Alpha beta hydrolase
APJL_RS03690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APJL_RS03710	COG1380	Effector of murein hydrolase LrgA
APJL_RS03715	COG1346	cytolysis
APJL_RS03730	COG3036	rescue of stalled ribosome
APJL_RS03735	COG2226	methyltransferase
APJL_RS03755	COG2333	competence protein COMEC
APJL_RS03755	COG0658	competence protein
APJL_RS03760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APJL_RS03770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APJL_RS03775	COG0737	Belongs to the 5'-nucleotidase family
APJL_RS03800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APJL_RS03805	COG0508	dehydrogenase complex catalyzes the overall conversion of
APJL_RS03810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APJL_RS03820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APJL_RS03835	COG1132	(ABC) transporter
APJL_RS03840	COG1346	cytolysis
APJL_RS03850	COG1199	ATP-dependent helicase activity
APJL_RS03860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APJL_RS03865	COG0629	single-stranded DNA binding
APJL_RS03900	COG2070	2-Nitropropane dioxygenase
APJL_RS03915	COG2315	Protein conserved in bacteria
APJL_RS03920	COG4172	Belongs to the ABC transporter superfamily
APJL_RS03925	COG4171	peptide transport system, permease
APJL_RS03930	COG4168	peptide transport system, permease
APJL_RS03935	COG4166	transmembrane transport
APJL_RS03940	COG3283	Transcriptional regulator of aromatic amino acids metabolism
APJL_RS03945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APJL_RS03950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APJL_RS03955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APJL_RS03965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APJL_RS03970	COG1368	sulfuric ester hydrolase activity
APJL_RS03975	COG0633	Ferredoxin
APJL_RS03975	COG3217	Mosc domain protein beta barrel domain protein
APJL_RS03980	COG1722	exodeoxyribonuclease VII activity
APJL_RS03985	COG0142	geranyltranstransferase activity
APJL_RS03995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APJL_RS04000	COG1530	ribonuclease E activity
APJL_RS04005	COG1944	ATP diphosphatase activity
APJL_RS04020	COG0500	methyltransferase
APJL_RS04030	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APJL_RS04050	COG2351	hydroxyisourate hydrolase activity
APJL_RS04060	COG0586	Pfam SNARE associated Golgi protein
APJL_RS04065	COG0187	DNA topoisomerase II activity
APJL_RS04075	COG1349	DNA-binding transcription factor activity
APJL_RS04080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APJL_RS04090	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APJL_RS04095	COG4988	ABC transporter
APJL_RS04100	COG2911	Protein conserved in bacteria
APJL_RS04105	COG0729	surface antigen
APJL_RS04110	COG2861	carbohydrate metabolic process
APJL_RS04115	COG4942	peptidase
APJL_RS04120	COG0588	phosphoglycerate mutase activity
APJL_RS04130	COG0572	uridine kinase
APJL_RS04135	COG0717	Belongs to the dCTP deaminase family
APJL_RS04140	COG1309	transcriptional regulator
APJL_RS04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APJL_RS04150	COG1129	ABC transporter
APJL_RS04150	COG0842	Transport permease protein
APJL_RS04155	COG0842	Transport permease protein
APJL_RS04165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APJL_RS04170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APJL_RS04175	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APJL_RS04195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APJL_RS04200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APJL_RS04210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APJL_RS04215	COG4166	transmembrane transport
APJL_RS04225	COG0444	Belongs to the ABC transporter superfamily
APJL_RS04230	COG4608	Belongs to the ABC transporter superfamily
APJL_RS04235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APJL_RS04240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APJL_RS04250	COG0747	negative chemotaxis
APJL_RS04255	COG0814	amino acid
APJL_RS04260	COG1760	l-serine dehydratase
APJL_RS04270	COG0135	phosphoribosylanthranilate isomerase activity
APJL_RS04270	COG0134	indole-3-glycerol-phosphate synthase activity
APJL_RS04275	COG3177	Filamentation induced by cAMP protein fic
APJL_RS04280	COG3098	single-species biofilm formation
APJL_RS04285	COG0564	pseudouridine synthase activity
APJL_RS04295	COG3025	triphosphatase activity
APJL_RS04300	COG3106	COG3106 Predicted ATPase
APJL_RS04305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APJL_RS04315	COG1473	amidohydrolase
APJL_RS04320	COG3069	C4-dicarboxylate transmembrane transporter activity
APJL_RS04330	COG0495	leucyl-tRNA aminoacylation
APJL_RS04335	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
APJL_RS04340	COG1466	dna polymerase III delta subunit
APJL_RS04345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APJL_RS04350	COG0237	dephospho-CoA kinase activity
APJL_RS04360	COG1459	type II secretion system
APJL_RS04365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APJL_RS04370	COG4969	Belongs to the N-Me-Phe pilin family
APJL_RS04375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APJL_RS04385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APJL_RS04390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APJL_RS04395	COG0730	response to heat
APJL_RS04405	COG0183	Belongs to the thiolase family
APJL_RS04410	COG1250	3-hydroxyacyl-CoA dehydrogenase
APJL_RS04410	COG1024	Enoyl-CoA hydratase
APJL_RS04425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APJL_RS04430	COG0243	molybdopterin cofactor binding
APJL_RS04430	COG3383	formate dehydrogenase (NAD+) activity
APJL_RS04435	COG3383	formate dehydrogenase (NAD+) activity
APJL_RS04435	COG0243	molybdopterin cofactor binding
APJL_RS04440	COG0437	4 iron, 4 sulfur cluster binding
APJL_RS04445	COG2864	formate dehydrogenase
APJL_RS04450	COG3058	Necessary for formate dehydrogenase activity
APJL_RS04480	COG1560	Kdo2-lipid A biosynthetic process
APJL_RS04485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APJL_RS04495	COG0302	gtp cyclohydrolase
APJL_RS04500	COG3642	lipopolysaccharide core region biosynthetic process
APJL_RS04510	COG0110	maltose O-acetyltransferase activity
APJL_RS04520	COG0583	DNA-binding transcription factor activity
APJL_RS04540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APJL_RS04550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APJL_RS04560	COG2963	transposase activity
APJL_RS04565	COG2801	Transposase and inactivated derivatives
APJL_RS04585	COG2975	iron-sulfur cluster assembly
APJL_RS04590	COG0633	Ferredoxin
APJL_RS04595	COG0443	Heat shock 70 kDa protein
APJL_RS04610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APJL_RS04620	COG0822	iron-sulfur transferase activity
APJL_RS04625	COG1104	cysteine desulfurase activity
APJL_RS04630	COG1959	2 iron, 2 sulfur cluster binding
APJL_RS04640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APJL_RS04645	COG2198	Histidine kinase
APJL_RS04645	COG5002	protein histidine kinase activity
APJL_RS04645	COG0784	Response regulator, receiver
APJL_RS04650	COG0697	spore germination
APJL_RS04655	COG2840	Smr protein MutS2
APJL_RS04660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APJL_RS04665	COG2226	methyltransferase
APJL_RS04670	COG2830	Protein of unknown function (DUF452)
APJL_RS04675	COG0156	8-amino-7-oxononanoate synthase activity
APJL_RS04680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APJL_RS04690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APJL_RS04695	COG2027	D-alanyl-D-alanine carboxypeptidase
APJL_RS04715	COG2801	Transposase and inactivated derivatives
APJL_RS04725	COG2856	Zn peptidase
APJL_RS04730	COG3620	sequence-specific DNA binding
APJL_RS04765	COG1444	tRNA N-acetyltransferase activity
APJL_RS04770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APJL_RS04775	COG0138	bifunctional purine biosynthesis protein purh
APJL_RS04780	COG2801	Transposase and inactivated derivatives
APJL_RS04810	COG3210	domain, Protein
APJL_RS04815	COG2831	hemolysin activation secretion protein
APJL_RS04825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APJL_RS04835	COG3078	GTPase activator activity
APJL_RS04845	COG0786	glutamate:sodium symporter activity
APJL_RS04860	COG2350	Protein conserved in bacteria
APJL_RS04865	COG1607	acyl-coa hydrolase
APJL_RS04880	COG3092	negative regulation of chromosome organization
APJL_RS04890	COG2056	Na+-H+ antiporter family
APJL_RS04895	COG0708	Exodeoxyribonuclease III
APJL_RS04900	COG0583	DNA-binding transcription factor activity
APJL_RS04920	COG0254	rRNA binding
APJL_RS04935	COG0753	catalase activity
APJL_RS04940	COG2963	transposase activity
APJL_RS04945	COG2801	Transposase and inactivated derivatives
APJL_RS04950	COG1408	metallophosphoesterase
APJL_RS04955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APJL_RS04960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APJL_RS04965	COG1085	galactose-1-phosphate uridylyltransferase
APJL_RS04975	COG2017	converts alpha-aldose to the beta-anomer
APJL_RS04995	COG0489	protein tyrosine kinase activity
APJL_RS05005	COG2095	MarC family integral membrane protein
APJL_RS05010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APJL_RS05020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APJL_RS05025	COG2354	Protein conserved in bacteria
APJL_RS05030	COG3071	HemY protein
APJL_RS05035	COG2959	enzyme of heme biosynthesis
APJL_RS05045	COG0181	hydroxymethylbilane synthase activity
APJL_RS05050	COG1454	alcohol dehydrogenase
APJL_RS05050	COG1012	belongs to the aldehyde dehydrogenase family
APJL_RS05075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APJL_RS05080	COG2364	Membrane
APJL_RS05085	COG0800	Aldolase
APJL_RS05090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APJL_RS05095	COG1904	glucuronate isomerase
APJL_RS05105	COG2186	Transcriptional regulator
APJL_RS05115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APJL_RS05115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APJL_RS05120	COG1216	Glycosyl transferase, family 2
APJL_RS05125	COG1216	Glycosyl transferase, family 2
APJL_RS05135	COG3306	glycosyltransferase involved in LPS biosynthesis
APJL_RS05145	COG5039	Polysaccharide pyruvyl transferase
APJL_RS05150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APJL_RS05155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APJL_RS05160	COG0077	Prephenate dehydratase
APJL_RS05160	COG1605	Chorismate mutase
APJL_RS05165	COG0339	signal peptide processing
APJL_RS05170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APJL_RS05175	COG1882	Formate acetyltransferase
APJL_RS05180	COG2116	formate transmembrane transporter activity
APJL_RS05185	COG1238	metal cluster binding
APJL_RS05190	COG0501	Belongs to the peptidase M48B family
APJL_RS05200	COG2431	L-lysine efflux transmembrane transporter activity
APJL_RS05205	COG1169	isochorismate synthase
APJL_RS05210	COG0436	Aminotransferase
APJL_RS05215	COG2962	Rard protein
APJL_RS05220	COG2962	Rard protein
APJL_RS05225	COG1280	lysine exporter protein (LysE YggA)
APJL_RS05230	COG4771	TonB-dependent receptor
APJL_RS05230	COG1629	transport
APJL_RS05235	COG0748	coenzyme F420 binding
APJL_RS05245	COG4235	cytochrome complex assembly
APJL_RS05245	COG3088	subunit of a heme lyase
APJL_RS05250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APJL_RS05255	COG1138	Cytochrome C-type biogenesis protein
APJL_RS05260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APJL_RS05260	COG0475	glutathione-regulated potassium exporter activity
APJL_RS05270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APJL_RS05275	COG2963	transposase activity
APJL_RS05280	COG2801	Transposase and inactivated derivatives
APJL_RS05285	COG3111	PFAM Bacterial OB fold (BOF) protein
APJL_RS05300	COG0745	RESPONSE REGULATOR receiver
APJL_RS05305	COG0642	Histidine kinase
APJL_RS05310	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APJL_RS05315	COG1862	Preprotein translocase
APJL_RS05320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APJL_RS05325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APJL_RS05330	COG1528	Iron-storage protein
APJL_RS05335	COG1528	Iron-storage protein
APJL_RS05340	COG2252	PERMEase
APJL_RS05345	COG0424	maF-like protein
APJL_RS05355	COG0301	tRNA thio-modification
APJL_RS05355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APJL_RS05365	COG0330	HflC and HflK could
APJL_RS05370	COG0330	HflC and HflK could
APJL_RS05375	COG3118	belongs to the thioredoxin family
APJL_RS05395	COG0531	amino acid
APJL_RS05400	COG0531	amino acid
APJL_RS05415	COG3047	cAMP biosynthetic process
APJL_RS05420	COG0542	response to heat
APJL_RS05425	COG0798	PFAM Bile acid sodium symporter
APJL_RS05430	COG1393	Belongs to the ArsC family
APJL_RS05440	COG1027	Aspartate ammonia-lyase
APJL_RS05450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APJL_RS05455	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APJL_RS05455	COG3583	domain protein
APJL_RS05455	COG3064	Membrane
APJL_RS05465	COG0720	synthase
APJL_RS05470	COG0602	queuosine metabolic process
APJL_RS05495	COG0795	lipopolysaccharide-transporting ATPase activity
APJL_RS05500	COG0795	lipopolysaccharide-transporting ATPase activity
APJL_RS05510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APJL_RS05535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APJL_RS05545	COG0861	Integral membrane protein TerC family
APJL_RS05565	COG1051	belongs to the nudix hydrolase family
APJL_RS05570	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
APJL_RS05580	COG1965	Belongs to the frataxin family
APJL_RS05595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APJL_RS05600	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APJL_RS05605	COG0564	pseudouridine synthase activity
APJL_RS05615	COG0205	6-phosphofructokinase activity
APJL_RS05620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APJL_RS05625	COG1525	nuclease
APJL_RS05630	COG1115	amino acid carrier protein
APJL_RS05635	COG0628	permease
APJL_RS05645	COG0826	peptidase U32
APJL_RS05650	COG3307	-O-antigen
APJL_RS05655	COG1519	Transferase
APJL_RS05665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APJL_RS05670	COG0802	atpase or kinase
APJL_RS05675	COG0860	N-Acetylmuramoyl-L-alanine amidase
APJL_RS05675	COG1388	LysM domain
APJL_RS05685	COG2960	long-chain fatty acid transporting porin activity
APJL_RS05710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APJL_RS05720	COG0551	DNA topoisomerase type I activity
APJL_RS05735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APJL_RS05740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APJL_RS05750	COG1322	Protein conserved in bacteria
APJL_RS05755	COG0512	Glutamine amidotransferase of anthranilate synthase
APJL_RS05765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APJL_RS05770	COG0494	nUDIX hydrolase
APJL_RS05785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APJL_RS05790	COG0612	Peptidase, M16
APJL_RS05800	COG0471	metal ion transport
APJL_RS05805	COG0583	DNA-binding transcription factor activity
APJL_RS05810	COG3266	domain, Protein
APJL_RS05815	COG1187	pseudouridine synthase activity
APJL_RS05820	COG0009	L-threonylcarbamoyladenylate synthase
APJL_RS05830	COG2837	iron assimilation
APJL_RS05835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APJL_RS05840	COG0512	Glutamine amidotransferase of anthranilate synthase
APJL_RS05850	COG2226	methyltransferase
APJL_RS05855	COG2268	Band 7 protein
APJL_RS05860	COG2841	Protein conserved in bacteria
APJL_RS05875	COG2965	DNA replication, synthesis of RNA primer
APJL_RS05890	COG3201	nicotinamide mononucleotide transporter
APJL_RS05895	COG2976	Protein conserved in bacteria
APJL_RS05905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APJL_RS05910	COG1426	Protein conserved in bacteria
APJL_RS05915	COG0659	secondary active sulfate transmembrane transporter activity
APJL_RS05925	COG0673	inositol 2-dehydrogenase activity
APJL_RS05930	COG0475	glutathione-regulated potassium exporter activity
APJL_RS05930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APJL_RS05960	COG2207	Transcriptional regulator
APJL_RS05970	COG1902	pentaerythritol trinitrate reductase activity
APJL_RS05975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APJL_RS05980	COG2084	Dehydrogenase
APJL_RS05985	COG0778	Nitroreductase
APJL_RS05990	COG2095	MarC family integral membrane protein
APJL_RS06005	COG0625	glutathione transferase activity
APJL_RS06020	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APJL_RS06025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APJL_RS06040	COG1275	C4-dicarboxylate transporter malic acid transport protein
APJL_RS06045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APJL_RS06055	COG1132	(ABC) transporter
APJL_RS06060	COG1854	S-ribosylhomocysteine lyase activity
APJL_RS06065	COG3008	intermembrane lipid transfer
APJL_RS06070	COG0735	belongs to the Fur family
APJL_RS06075	COG0716	FMN binding
APJL_RS06085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APJL_RS06090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APJL_RS06095	COG2252	PERMEase
APJL_RS06100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APJL_RS06105	COG2081	HI0933 family
APJL_RS06110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APJL_RS06120	COG0560	Phosphoserine phosphatase
APJL_RS06135	COG0058	SHG alpha-glucan phosphorylase activity
APJL_RS06140	COG2909	trisaccharide binding
APJL_RS06150	COG4580	involved in the transport of maltose and maltodextrins
APJL_RS06155	COG3842	ATPase activity
APJL_RS06170	COG3833	ABC-type maltose transport systems, permease component
APJL_RS06175	COG1640	4-alpha-glucanotransferase
APJL_RS06180	COG1966	Carbon starvation protein
APJL_RS06185	COG0084	hydrolase, TatD family'
APJL_RS06190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APJL_RS06200	COG0778	Nitroreductase
APJL_RS06215	COG4172	Belongs to the ABC transporter superfamily
APJL_RS06220	COG0191	fructose-bisphosphate aldolase activity
APJL_RS06225	COG0126	phosphoglycerate kinase activity
APJL_RS06230	COG0471	metal ion transport
APJL_RS06235	COG0471	metal ion transport
APJL_RS06240	COG0471	metal ion transport
APJL_RS06245	COG0187	DNA topoisomerase II activity
APJL_RS06250	COG5002	protein histidine kinase activity
APJL_RS06255	COG0745	RESPONSE REGULATOR receiver
APJL_RS06280	COG0789	Transcriptional regulator
APJL_RS06290	COG2217	Heavy metal translocating P-type atpase
APJL_RS06300	COG0300	oxidoreductase activity
APJL_RS06305	COG0778	Nitroreductase
APJL_RS06310	COG0616	signal peptide processing
APJL_RS06315	COG3719	Belongs to the RNase T2 family
APJL_RS06325	COG1252	NADH dehydrogenase
APJL_RS06330	COG2183	response to ionizing radiation
APJL_RS06335	COG3063	Type IV pilus biogenesis stability protein PilW
APJL_RS06375	COG2161	toxin-antitoxin pair type II binding
APJL_RS06380	COG4115	mRNA cleavage
APJL_RS06385	COG2835	tetraacyldisaccharide 4'-kinase activity
APJL_RS06390	COG1663	tetraacyldisaccharide 4'-kinase activity
APJL_RS06395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APJL_RS06400	COG0740	serine-type endopeptidase activity
APJL_RS06405	COG2166	iron-sulfur cluster assembly
APJL_RS06425	COG0488	(ABC) transporter
APJL_RS06430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APJL_RS06450	COG5007	Belongs to the BolA IbaG family
APJL_RS06460	COG2854	intermembrane phospholipid transfer
APJL_RS06465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APJL_RS06470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APJL_RS06475	COG1127	ABC transporter
APJL_RS06480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APJL_RS06485	COG1090	epimerase
APJL_RS06505	COG0563	adenylate kinase activity
APJL_RS06515	COG2814	Major facilitator Superfamily
APJL_RS06545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APJL_RS06555	COG1794	racemase activity, acting on amino acids and derivatives
APJL_RS06560	COG2814	Major facilitator Superfamily
APJL_RS06565	COG0363	glucosamine-6-phosphate deaminase activity
APJL_RS06570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APJL_RS06575	COG1218	3'(2'),5'-bisphosphate nucleotidase
APJL_RS06580	COG0494	nUDIX hydrolase
APJL_RS06585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APJL_RS06595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APJL_RS06600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APJL_RS06615	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APJL_RS06620	COG1178	ABC-type Fe3 transport system permease component
APJL_RS06625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APJL_RS06630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APJL_RS06635	COG2190	(PTS) system
APJL_RS06645	COG0210	DNA helicase
APJL_RS06650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APJL_RS06655	COG0409	Hydrogenase expression formation protein
APJL_RS06660	COG0309	Hydrogenase expression formation protein (HypE)
APJL_RS06685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APJL_RS06690	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APJL_RS06695	COG0437	4 iron, 4 sulfur cluster binding
APJL_RS06700	COG5557	Pfam Polysulphide reductase, NrfD
APJL_RS06705	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APJL_RS06710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APJL_RS06715	COG1773	rubredoxin
APJL_RS06720	COG0298	carbon dioxide binding
APJL_RS06725	COG0375	protein maturation
APJL_RS06760	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APJL_RS06765	COG0308	aminopeptidase N
APJL_RS06770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APJL_RS06775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APJL_RS06780	COG0295	cytidine deaminase activity
APJL_RS06785	COG2177	Part of the ABC transporter FtsEX involved in
APJL_RS06790	COG2884	Cell division ATP-binding protein ftsE
APJL_RS06795	COG0552	protein localization to endoplasmic reticulum
APJL_RS06800	COG0742	ribosomal rna small subunit methyltransferase
APJL_RS06805	COG3099	Belongs to the UPF0263 family
APJL_RS06810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APJL_RS06820	COG4160	amino acid transport
APJL_RS06825	COG4215	(ABC) transporter
APJL_RS06830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APJL_RS06835	COG1126	abc transporter atp-binding protein
APJL_RS06840	COG1881	PFAM PEBP family protein
APJL_RS06850	COG3620	sequence-specific DNA binding
APJL_RS06860	COG4232	protein-disulfide reductase activity
APJL_RS06865	COG3101	peptidyl-lysine hydroxylation
APJL_RS06875	COG3107	peptidoglycan biosynthetic process
APJL_RS06885	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APJL_RS06915	COG1138	Cytochrome C-type biogenesis protein
APJL_RS06925	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APJL_RS06930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APJL_RS06935	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APJL_RS06940	COG4133	protoheme IX ABC transporter activity
APJL_RS06945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APJL_RS06980	COG3630	sodium ion export across plasma membrane
APJL_RS06990	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APJL_RS06995	COG2824	Alkylphosphonate utilization operon protein PhnA
APJL_RS07000	COG1858	cytochrome C peroxidase
APJL_RS07010	COG0762	integral membrane protein
APJL_RS07015	COG3171	Protein conserved in bacteria
APJL_RS07020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APJL_RS07025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APJL_RS07030	COG0416	fatty acid biosynthetic process
APJL_RS07035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APJL_RS07040	COG1399	metal-binding, possibly nucleic acid-binding protein
APJL_RS07045	COG4137	Cytochrome C assembly protein
APJL_RS07050	COG4536	flavin adenine dinucleotide binding
APJL_RS07055	COG0733	neurotransmitter:sodium symporter activity
APJL_RS07065	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APJL_RS07065	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APJL_RS07070	COG3715	PTS system
APJL_RS07075	COG3716	PTS system mannose fructose sorbose family IID component
APJL_RS07095	COG1840	ABC-type Fe3 transport system, periplasmic component
APJL_RS07110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APJL_RS07125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APJL_RS07135	COG0049	tRNA binding
APJL_RS07140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APJL_RS07145	COG0859	PFAM glycosyl transferase family 9
APJL_RS07150	COG0859	PFAM glycosyl transferase family 9
APJL_RS07160	COG3061	Opacity-associated protein A
APJL_RS07160	COG3266	domain, Protein
APJL_RS07165	COG1555	photosystem II stabilization
APJL_RS07195	COG4974	Belongs to the 'phage' integrase family
APJL_RS07205	COG1181	Belongs to the D-alanine--D-alanine ligase family
APJL_RS07205	COG2918	glutathione biosynthetic process
APJL_RS07215	COG0814	amino acid
APJL_RS07220	COG3691	Protein conserved in bacteria
APJL_RS07230	COG1022	Amp-dependent synthetase and ligase
APJL_RS07255	COG4211	Belongs to the binding-protein-dependent transport system permease family
APJL_RS07260	COG1129	ABC transporter
APJL_RS07265	COG1879	ABC-type sugar transport system periplasmic component
APJL_RS07270	COG2885	chlorophyll binding
APJL_RS07270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APJL_RS07275	COG0247	lactate metabolic process
APJL_RS07275	COG0277	FAD linked oxidase domain protein
APJL_RS07280	COG2050	protein possibly involved in aromatic compounds catabolism
APJL_RS07290	COG3005	denitrification pathway
APJL_RS07295	COG3043	anaerobic respiration
APJL_RS07300	COG0348	domain, Protein
APJL_RS07305	COG0437	4 iron, 4 sulfur cluster binding
APJL_RS07310	COG0243	molybdopterin cofactor binding
APJL_RS07320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APJL_RS07325	COG2249	NAD(P)H dehydrogenase (quinone) activity
APJL_RS07330	COG2801	Transposase and inactivated derivatives
APJL_RS07335	COG2963	transposase activity
APJL_RS07345	COG1530	ribonuclease E activity
APJL_RS07355	COG1755	Isoprenylcysteine carboxyl methyltransferase
APJL_RS07365	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APJL_RS07375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APJL_RS07385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APJL_RS07400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APJL_RS07410	COG1720	tRNA m6t6A37 methyltransferase activity
APJL_RS07415	COG4804	nuclease activity
APJL_RS07420	COG1575	Belongs to the MenA family. Type 1 subfamily
APJL_RS07430	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APJL_RS07440	COG0438	transferase activity, transferring glycosyl groups
APJL_RS07450	COG0438	transferase activity, transferring glycosyl groups
APJL_RS07460	COG2244	polysaccharide biosynthetic process
APJL_RS07465	COG0562	UDP-galactopyranose mutase
APJL_RS07470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APJL_RS07475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APJL_RS07495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APJL_RS07505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APJL_RS07510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APJL_RS07520	COG0557	exoribonuclease II activity
APJL_RS07525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APJL_RS07530	COG1309	transcriptional regulator
APJL_RS07535	COG0583	DNA-binding transcription factor activity
APJL_RS07540	COG0678	peroxiredoxin activity
APJL_RS07540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APJL_RS07565	COG0825	malonyl-CoA metabolic process
APJL_RS07575	COG0204	Acyl-transferase
APJL_RS07580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APJL_RS07605	COG0783	Belongs to the Dps family
APJL_RS07620	COG1289	transmembrane transporter activity
APJL_RS07625	COG1803	Methylglyoxal synthase
APJL_RS07630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APJL_RS07635	COG2963	transposase activity
APJL_RS07640	COG2801	Transposase and inactivated derivatives
APJL_RS07655	COG2153	protein acetylation
APJL_RS07660	COG2927	DNA polymerase III (CHI subunit)
APJL_RS07665	COG1652	LysM domain
APJL_RS07675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APJL_RS07690	COG1045	serine acetyltransferase
APJL_RS07695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APJL_RS07720	COG1072	(Pantothenic acid kinase))
APJL_RS07725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APJL_RS07740	COG0521	Mo-molybdopterin cofactor biosynthetic process
APJL_RS07750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APJL_RS07760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APJL_RS07775	COG0625	glutathione transferase activity
APJL_RS07780	COG0019	diaminopimelate decarboxylase activity
APJL_RS07790	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APJL_RS07795	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APJL_RS07800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APJL_RS07805	COG1053	succinate dehydrogenase
APJL_RS07810	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APJL_RS07820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APJL_RS07825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APJL_RS07875	COG4974	Belongs to the 'phage' integrase family
APJL_RS07930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APJL_RS07945	COG1151	hydroxylamine reductase activity
APJL_RS07950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APJL_RS07955	COG2244	polysaccharide biosynthetic process
APJL_RS07960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APJL_RS07970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APJL_RS07975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APJL_RS07980	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APJL_RS08000	COG0728	peptidoglycan biosynthetic process
APJL_RS08005	COG0268	Binds directly to 16S ribosomal RNA
APJL_RS08010	COG0569	domain protein
APJL_RS08015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APJL_RS08020	COG3276	selenocysteine insertion sequence binding
APJL_RS08025	COG1921	L-seryl-tRNASec selenium transferase activity
APJL_RS08035	COG0716	FMN binding
APJL_RS08055	COG4771	TonB-dependent receptor
APJL_RS08055	COG1629	transport
APJL_RS08080	COG2431	L-lysine efflux transmembrane transporter activity
APJL_RS08085	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APJL_RS08090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APJL_RS08125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APJL_RS08155	COG1119	ATPase activity
APJL_RS08170	COG1739	Uncharacterized protein family UPF0029
APJL_RS08175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APJL_RS08180	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APJL_RS08200	COG2921	Belongs to the UPF0250 family
APJL_RS08205	COG1686	Belongs to the peptidase S11 family
APJL_RS08210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APJL_RS08215	COG0772	Belongs to the SEDS family
APJL_RS08220	COG0768	penicillin binding
APJL_RS08230	COG0799	negative regulation of ribosome biogenesis
APJL_RS08240	COG1126	abc transporter atp-binding protein
APJL_RS08245	COG0765	amino acid transport
APJL_RS08255	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
APJL_RS08265	COG3691	Protein conserved in bacteria
APJL_RS08310	COG0832	Belongs to the urease beta subunit family
APJL_RS08315	COG0831	urea catabolic process
APJL_RS08325	COG1122	ATPase activity
APJL_RS08330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APJL_RS08335	COG0310	cobalt ion transport
APJL_RS08340	COG0310	cobalt ion transport
APJL_RS08345	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
APJL_RS08350	COG0583	DNA-binding transcription factor activity
APJL_RS08360	COG0490	domain, Protein
APJL_RS08360	COG0471	metal ion transport
APJL_RS08365	COG3722	fumarate hydratase activity
APJL_RS08380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APJL_RS08385	COG1349	DNA-binding transcription factor activity
APJL_RS08400	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
APJL_RS08415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APJL_RS08420	COG2900	Belongs to the SlyX family
APJL_RS08425	COG0545	Peptidyl-prolyl cis-trans isomerase
APJL_RS08430	COG2964	Protein conserved in bacteria
APJL_RS08435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APJL_RS08445	COG2168	tRNA wobble position uridine thiolation
APJL_RS08495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APJL_RS08530	COG0561	phosphatase activity
APJL_RS08535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APJL_RS08540	COG3012	SEC-C Motif Domain Protein
APJL_RS08550	COG3716	PTS system mannose fructose sorbose family IID component
APJL_RS08555	COG3715	PTS system
APJL_RS08560	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APJL_RS08560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APJL_RS08565	COG2610	gluconate transmembrane transporter activity
APJL_RS08570	COG3265	gluconokinase activity
APJL_RS08575	COG1609	Transcriptional regulator
APJL_RS08580	COG1609	Transcriptional regulator
APJL_RS08585	COG1869	D-ribose catabolic process
APJL_RS08595	COG1172	Belongs to the binding-protein-dependent transport system permease family
APJL_RS08600	COG1879	ABC-type sugar transport system periplasmic component
APJL_RS08605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APJL_RS08610	COG0243	molybdopterin cofactor binding
APJL_RS08615	COG0437	4 iron, 4 sulfur cluster binding
APJL_RS08620	COG3302	dmso reductase anchor subunit
APJL_RS08625	COG3381	protein complex oligomerization
APJL_RS08630	COG2221	Nitrite and sulphite reductase 4Fe-4S
APJL_RS08630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APJL_RS08660	COG1349	DNA-binding transcription factor activity
APJL_RS08665	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
APJL_RS08670	COG1070	Carbohydrate kinase
APJL_RS08675	COG4154	Belongs to the RbsD FucU family
APJL_RS08680	COG0235	Class ii aldolase
APJL_RS08685	COG0738	Major facilitator superfamily
APJL_RS08690	COG1454	alcohol dehydrogenase
APJL_RS08695	COG3477	response to acidic pH
APJL_RS08700	COG0765	amino acid transport
APJL_RS08710	COG1126	abc transporter atp-binding protein
APJL_RS08715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APJL_RS08735	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APJL_RS08760	COG3623	hexulose-6-phosphate isomerase
APJL_RS08765	COG0235	Class ii aldolase
APJL_RS08780	COG1476	TRANSCRIPTIONal
APJL_RS08790	COG4783	chaperone-mediated protein folding
APJL_RS08795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APJL_RS08805	COG0758	DNA mediated transformation
APJL_RS08810	COG1297	OPT oligopeptide transporter protein
APJL_RS08825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APJL_RS08835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APJL_RS08850	COG0222	ribosome binding
APJL_RS08910	COG1487	ribonuclease activity
APJL_RS08935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APJL_RS08945	COG0346	lactoylglutathione lyase activity
APJL_RS08950	COG1194	a g-specific adenine glycosylase
APJL_RS08955	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APJL_RS08960	COG0741	lytic transglycosylase activity
APJL_RS08985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APJL_RS08990	COG0737	Belongs to the 5'-nucleotidase family
APJL_RS08995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APJL_RS09000	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APJL_RS09005	COG0606	chelatase, subunit chli
APJL_RS09015	COG2267	carboxylic ester hydrolase activity
APJL_RS09050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APJL_RS09065	COG0051	transcription antitermination factor activity, RNA binding
APJL_RS09070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APJL_RS09075	COG0088	Forms part of the polypeptide exit tunnel
APJL_RS09080	COG0089	rRNA binding
APJL_RS09085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APJL_RS09090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APJL_RS09095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APJL_RS09100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APJL_RS09105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APJL_RS09110	COG0255	Belongs to the universal ribosomal protein uL29 family
APJL_RS09115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APJL_RS09130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APJL_RS09140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APJL_RS09145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APJL_RS09150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APJL_RS09155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APJL_RS09160	COG1841	ribosomal large subunit assembly
APJL_RS09165	COG0200	Binds to the 23S rRNA
APJL_RS09170	COG0201	protein transport
APJL_RS09180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APJL_RS09185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APJL_RS09190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APJL_RS09195	COG0202	RNA polymerase activity
APJL_RS09205	COG0228	four-way junction DNA binding
APJL_RS09210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APJL_RS09215	COG0336	Belongs to the RNA methyltransferase TrmD family
APJL_RS09220	COG0335	large ribosomal subunit rRNA binding
APJL_RS09225	COG2850	peptidyl-arginine hydroxylation
APJL_RS09230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APJL_RS09235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APJL_RS09280	COG2852	Protein conserved in bacteria
APJL_RS09305	COG2832	Protein of unknown function (DUF454)
APJL_RS09315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APJL_RS09325	COG0084	hydrolase, TatD family'
APJL_RS09340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APJL_RS09350	COG0470	DNA polymerase III
APJL_RS09355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APJL_RS09360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APJL_RS09380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APJL_RS09385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APJL_RS09390	COG0254	rRNA binding
APJL_RS09395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APJL_RS09400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APJL_RS09405	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APJL_RS09410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APJL_RS09420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APJL_RS09445	COG1595	DNA-templated transcription, initiation
APJL_RS09460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APJL_RS09480	COG2502	aspartate--ammonia ligase
APJL_RS09485	COG1522	sequence-specific DNA binding
APJL_RS09490	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APJL_RS09495	COG3161	chorismate lyase activity
APJL_RS09560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APJL_RS09570	COG4208	sulfate ABC transporter
APJL_RS09575	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APJL_RS09590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APJL_RS09600	COG2963	transposase activity
APJL_RS09605	COG2801	Transposase and inactivated derivatives
APJL_RS09610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APJL_RS09615	COG2995	paraquat-inducible protein a
APJL_RS09620	COG1305	Transglutaminase-like
APJL_RS09630	COG2608	mercury ion transmembrane transporter activity
APJL_RS09635	COG1979	alcohol dehydrogenase
APJL_RS09640	COG0583	DNA-binding transcription factor activity
APJL_RS09645	COG2171	N-acyltransferase activity
APJL_RS09650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APJL_RS09660	COG0511	ligase activity, forming carbon-carbon bonds
APJL_RS09665	COG0439	Biotin carboxylase
APJL_RS09675	COG3084	Protein conserved in bacteria
APJL_RS09680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APJL_RS09690	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APJL_RS09690	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APJL_RS09700	COG1876	peptidase activity
APJL_RS09710	COG1393	Belongs to the ArsC family
APJL_RS09720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APJL_RS09725	COG0564	pseudouridine synthase activity
APJL_RS09735	COG0668	transmembrane transport
APJL_RS09740	COG0439	Biotin carboxylase
APJL_RS09750	COG1025	Belongs to the peptidase M16 family
APJL_RS09755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APJL_RS09780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APJL_RS09785	COG1067	ATP-dependent peptidase activity
APJL_RS09790	COG3120	sequence-specific DNA binding
APJL_RS09795	COG0180	Tryptophanyl-tRNA synthetase
APJL_RS09815	COG0730	response to heat
APJL_RS09830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APJL_RS09840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APJL_RS09845	COG2116	formate transmembrane transporter activity
APJL_RS09855	COG2801	Transposase and inactivated derivatives
APJL_RS09860	COG2963	transposase activity
APJL_RS09880	COG1070	Carbohydrate kinase
APJL_RS09885	COG2115	Belongs to the xylose isomerase family
APJL_RS09890	COG4213	ABC transporter substrate-binding protein
APJL_RS09895	COG1129	ABC transporter
APJL_RS09900	COG4214	carbohydrate transport
APJL_RS09905	COG2207	Transcriptional regulator
APJL_RS09905	COG1609	Transcriptional regulator
APJL_RS09910	COG3590	peptidase
APJL_RS09920	COG4145	pantothenate transmembrane transporter activity
APJL_RS09925	COG3924	membrane
APJL_RS09930	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
APJL_RS09935	COG2853	Lipoprotein
APJL_RS09940	COG0676	glucose-6-phosphate 1-epimerase activity
APJL_RS09955	COG1649	PFAM Uncharacterised BCR, COG1649
APJL_RS09955	COG0726	polysaccharide deacetylase
APJL_RS09960	COG1215	transferase activity, transferring glycosyl groups
APJL_RS09970	COG0149	triose-phosphate isomerase activity
APJL_RS09980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APJL_RS09985	COG1238	metal cluster binding
APJL_RS10000	COG1388	LysM domain
APJL_RS10000	COG4942	peptidase
APJL_RS10005	COG2818	Glycosylase
APJL_RS10015	COG0700	Nucleoside recognition
APJL_RS10020	COG3366	ferrous iron transmembrane transporter activity
APJL_RS10030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APJL_RS10035	COG0594	ribonuclease P activity
APJL_RS10040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APJL_RS10045	COG0174	glutamine synthetase
APJL_RS10050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APJL_RS10055	COG0494	nUDIX hydrolase
APJL_RS10085	COG1490	D-aminoacyl-tRNA deacylase activity
APJL_RS10090	COG1295	ribonuclease BN
APJL_RS10130	COG1064	alcohol dehydrogenase
APJL_RS10145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APJL_RS10150	COG1611	Belongs to the LOG family
APJL_RS10155	COG1694	Mazg nucleotide pyrophosphohydrolase
APJL_RS10170	COG1309	transcriptional regulator
APJL_RS10180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APJL_RS10185	COG2003	Belongs to the UPF0758 family
APJL_RS10190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APJL_RS10195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APJL_RS10210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APJL_RS10215	COG0076	glutamate decarboxylase activity
APJL_RS10220	COG0425	Belongs to the sulfur carrier protein TusA family
APJL_RS10225	COG2391	methyltransferase activity
APJL_RS10230	COG3085	chromosome segregation
APJL_RS10250	COG0598	Magnesium transport protein CorA
APJL_RS10255	COG2226	methyltransferase
APJL_RS10270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APJL_RS10275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APJL_RS10280	COG0805	protein transport
APJL_RS10300	COG1114	Component of the transport system for branched-chain amino acids
APJL_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
APJL_RS10310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APJL_RS10315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APJL_RS10320	COG0142	geranyltranstransferase activity
APJL_RS10330	COG0431	NADPH-dependent FMN reductase
APJL_RS10335	COG2259	Doxx family
APJL_RS10340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APJL_RS10345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APJL_RS10350	COG0697	spore germination
APJL_RS10355	COG4783	chaperone-mediated protein folding
APJL_RS10365	COG1040	competence protein
APJL_RS10380	COG0456	acetyltransferase
APJL_RS10385	COG0513	Belongs to the DEAD box helicase family
APJL_RS10395	COG0747	negative chemotaxis
APJL_RS10405	COG1584	GPR1 FUN34 yaaH family protein
APJL_RS10410	COG1120	ATPase activity
APJL_RS10415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APJL_RS10435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APJL_RS10440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APJL_RS10445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APJL_RS10450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APJL_RS10470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APJL_RS10485	COG0140	phosphoribosyl-ATP diphosphatase activity
APJL_RS10485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APJL_RS10490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APJL_RS10495	COG0024	Methionine aminopeptidase
APJL_RS10515	COG1621	beta-fructofuranosidase activity
APJL_RS10520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APJL_RS10530	COG4591	ABC-type transport system involved in lipoprotein release permease component
APJL_RS10535	COG1136	(ABC) transporter
APJL_RS10540	COG4591	ABC-type transport system involved in lipoprotein release permease component
APJL_RS10545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APJL_RS10575	COG2897	thiosulfate sulfurtransferase activity
APJL_RS10580	COG2391	methyltransferase activity