locus-tag	class	description
APP7_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APP7_RS00010	COG0592	DNA-directed DNA polymerase activity
APP7_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APP7_RS00040	COG0616	signal peptide processing
APP7_RS00045	COG2001	Belongs to the MraZ family
APP7_RS00055	COG3116	cell division
APP7_RS00060	COG0768	penicillin binding
APP7_RS00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APP7_RS00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APP7_RS00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APP7_RS00085	COG0772	Belongs to the SEDS family
APP7_RS00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
APP7_RS00110	COG0849	cell division
APP7_RS00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APP7_RS00125	COG0497	DNA recombination
APP7_RS00130	COG4172	Belongs to the ABC transporter superfamily
APP7_RS00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APP7_RS00140	COG0601	transmembrane transport
APP7_RS00170	COG0012	GTP binding
APP7_RS00175	COG2020	methyltransferase activity
APP7_RS00185	COG3133	Outer membrane lipoprotein
APP7_RS00190	COG3102	Protein conserved in bacteria
APP7_RS00195	COG0018	arginyl-trna synthetase
APP7_RS00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APP7_RS00215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APP7_RS00225	COG0196	riboflavin kinase activity
APP7_RS00230	COG3172	ATPase kinase involved in NAD metabolism
APP7_RS00235	COG2129	metallophosphoesterase
APP7_RS00240	COG0745	RESPONSE REGULATOR receiver
APP7_RS00250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APP7_RS00255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APP7_RS00265	COG1217	gtp-binding protein TYPA
APP7_RS00270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APP7_RS00280	COG1561	YicC-like family, N-terminal region
APP7_RS00285	COG0354	folic acid binding
APP7_RS00290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APP7_RS00295	COG2197	response regulator
APP7_RS00305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APP7_RS00340	COG0747	negative chemotaxis
APP7_RS00345	COG0747	negative chemotaxis
APP7_RS00350	COG0601	transmembrane transport
APP7_RS00355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APP7_RS00360	COG0444	Belongs to the ABC transporter superfamily
APP7_RS00365	COG4608	Belongs to the ABC transporter superfamily
APP7_RS00380	COG0251	oxidation-reduction process
APP7_RS00385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APP7_RS00390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APP7_RS00395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APP7_RS00400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APP7_RS00405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APP7_RS00410	COG0848	biopolymer transport protein
APP7_RS00415	COG0811	peptide transport
APP7_RS00425	COG3118	belongs to the thioredoxin family
APP7_RS00430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_RS00430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APP7_RS00430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APP7_RS00435	COG1461	Dihydroxyacetone kinase
APP7_RS00440	COG2376	Dihydroxyacetone kinase
APP7_RS00445	COG0492	ferredoxin-NADP+ reductase activity
APP7_RS00470	COG3030	protein affecting phage T7 exclusion by the F plasmid
APP7_RS00485	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
APP7_RS00510	COG3978	acetolactate synthase activity
APP7_RS00525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APP7_RS00530	COG0437	4 iron, 4 sulfur cluster binding
APP7_RS00535	COG3301	Polysulphide reductase, NrfD
APP7_RS00565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APP7_RS00570	COG1414	Transcriptional regulator
APP7_RS00575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APP7_RS00580	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APP7_RS00590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APP7_RS00595	COG3068	Protein conserved in bacteria
APP7_RS00620	COG1278	Cold shock
APP7_RS00625	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
APP7_RS00630	COG0793	Belongs to the peptidase S41A family
APP7_RS00640	COG3108	Peptidase M15
APP7_RS00645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP7_RS00660	COG0537	adenosine 5'-monophosphoramidase activity
APP7_RS00665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP7_RS00670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP7_RS00680	COG1162	GTPase activity
APP7_RS00685	COG0583	DNA-binding transcription factor activity
APP7_RS00690	COG1011	Hydrolase
APP7_RS00695	COG0583	DNA-binding transcription factor activity
APP7_RS00705	COG0252	asparaginase activity
APP7_RS00715	COG5413	integral membrane protein
APP7_RS00730	COG3835	regulator
APP7_RS00735	COG2610	gluconate transmembrane transporter activity
APP7_RS00740	COG1929	Belongs to the glycerate kinase type-1 family
APP7_RS00745	COG1254	Belongs to the acylphosphatase family
APP7_RS00750	COG3593	DNA synthesis involved in DNA repair
APP7_RS00755	COG1611	Belongs to the LOG family
APP7_RS00760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APP7_RS00770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP7_RS00775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APP7_RS00775	COG0316	Belongs to the HesB IscA family
APP7_RS00780	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APP7_RS00785	COG1805	sodium ion transport
APP7_RS00790	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APP7_RS00795	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APP7_RS00805	COG2871	sodium ion transport
APP7_RS00810	COG1477	protein flavinylation
APP7_RS00815	COG2991	Protein conserved in bacteria
APP7_RS00825	COG2814	Major facilitator Superfamily
APP7_RS00830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APP7_RS00840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APP7_RS00860	COG4657	Part of a membrane complex involved in electron transport
APP7_RS00865	COG2878	Part of a membrane complex involved in electron transport
APP7_RS00870	COG4656	Part of a membrane complex involved in electron transport
APP7_RS00895	COG1560	Kdo2-lipid A biosynthetic process
APP7_RS00900	COG0402	S-adenosylhomocysteine deaminase activity
APP7_RS00905	COG4143	(ABC) transporter
APP7_RS00910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APP7_RS00915	COG0617	tRNA 3'-terminal CCA addition
APP7_RS00920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APP7_RS00930	COG2911	Protein conserved in bacteria
APP7_RS00940	COG0346	lactoylglutathione lyase activity
APP7_RS00945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APP7_RS00955	COG1605	Chorismate mutase
APP7_RS00955	COG0287	Prephenate dehydrogenase
APP7_RS00960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APP7_RS00965	COG0859	PFAM glycosyl transferase family 9
APP7_RS00970	COG0469	pyruvate kinase activity
APP7_RS00975	COG2062	phosphohistidine phosphatase, SixA
APP7_RS00980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APP7_RS00985	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APP7_RS00990	COG0733	neurotransmitter:sodium symporter activity
APP7_RS00995	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APP7_RS01000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APP7_RS01005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APP7_RS01010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APP7_RS01015	COG4972	Pilus assembly protein
APP7_RS01035	COG4796	Type ii and iii secretion system protein
APP7_RS01040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APP7_RS01045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APP7_RS01050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APP7_RS01055	COG1280	lysine exporter protein (LysE YggA)
APP7_RS01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APP7_RS01070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APP7_RS01075	COG2801	Transposase and inactivated derivatives
APP7_RS01080	COG2963	transposase activity
APP7_RS01090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APP7_RS01145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APP7_RS01150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APP7_RS01170	COG1253	flavin adenine dinucleotide binding
APP7_RS01175	COG0564	pseudouridine synthase activity
APP7_RS01180	COG0588	phosphoglycerate mutase activity
APP7_RS01190	COG1678	Uncharacterized ACR, COG1678
APP7_RS01195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APP7_RS01205	COG0271	Belongs to the BolA IbaG family
APP7_RS01240	COG0494	nUDIX hydrolase
APP7_RS01245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APP7_RS01255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APP7_RS01265	COG4771	TonB-dependent receptor
APP7_RS01265	COG1629	transport
APP7_RS01270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APP7_RS01275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APP7_RS01280	COG0083	homoserine kinase activity
APP7_RS01285	COG0527	aspartate kinase activity
APP7_RS01285	COG0460	homoserine dehydrogenase
APP7_RS01290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APP7_RS01295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APP7_RS01300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APP7_RS01325	COG2195	Cleaves the N-terminal amino acid of tripeptides
APP7_RS01330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APP7_RS01335	COG0194	GDP metabolic process
APP7_RS01340	COG1538	Outer membrane efflux protein
APP7_RS01345	COG2914	Belongs to the UPF0125 (RnfH) family
APP7_RS01350	COG2867	negative regulation of translational initiation
APP7_RS01355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APP7_RS01360	COG4149	molybdate abc transporter
APP7_RS01365	COG0725	ABC transporter, periplasmic molybdate-binding protein
APP7_RS01370	COG0842	Transport permease protein
APP7_RS01375	COG1131	(ABC) transporter
APP7_RS01380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APP7_RS01385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APP7_RS01395	COG0251	oxidation-reduction process
APP7_RS01405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APP7_RS01410	COG1121	(ABC) transporter
APP7_RS01420	COG2920	part of a sulfur-relay system
APP7_RS01425	COG0670	Belongs to the BI1 family
APP7_RS01430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APP7_RS01445	COG0084	hydrolase, TatD family'
APP7_RS01450	COG0210	DNA helicase
APP7_RS01455	COG3842	ATPase activity
APP7_RS01460	COG1176	ABC-type spermidine putrescine transport system, permease component I
APP7_RS01465	COG1177	transmembrane transport
APP7_RS01490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APP7_RS01510	COG0732	type I restriction modification DNA specificity domain
APP7_RS01525	COG0488	(ABC) transporter
APP7_RS01530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APP7_RS01540	COG1271	oxidase subunit
APP7_RS01545	COG1294	oxidase, subunit
APP7_RS01555	COG0824	Thioesterase
APP7_RS01560	COG0811	peptide transport
APP7_RS01565	COG0848	biopolymer transport protein
APP7_RS01570	COG3064	Membrane
APP7_RS01570	COG3064	Membrane
APP7_RS01590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APP7_RS01595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APP7_RS01605	COG0488	(ABC) transporter
APP7_RS01615	COG0303	'Molybdopterin
APP7_RS01620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APP7_RS01630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APP7_RS01635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APP7_RS01645	COG0564	pseudouridine synthase activity
APP7_RS01650	COG3023	N-Acetylmuramoyl-L-alanine amidase
APP7_RS01655	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APP7_RS01660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APP7_RS01665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APP7_RS01670	COG0626	cystathionine gamma-synthase activity
APP7_RS01675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APP7_RS01690	COG1702	phosphate starvation-inducible protein PhoH
APP7_RS01700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APP7_RS01705	COG0709	Synthesizes selenophosphate from selenide and ATP
APP7_RS01715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP7_RS01735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP7_RS01745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_RS01750	COG1137	ATPase activity
APP7_RS01755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APP7_RS01765	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APP7_RS01770	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APP7_RS01780	COG1704	LemA family
APP7_RS01785	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APP7_RS01785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP7_RS01785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP7_RS01790	COG1105	Belongs to the carbohydrate kinase PfkB family
APP7_RS01795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_RS01795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_RS01805	COG1523	belongs to the glycosyl hydrolase 13 family
APP7_RS01810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APP7_RS01815	COG0297	glycogen (starch) synthase activity
APP7_RS01820	COG0058	SHG alpha-glucan phosphorylase activity
APP7_RS01840	COG1187	pseudouridine synthase activity
APP7_RS01845	COG2814	Major facilitator Superfamily
APP7_RS01855	COG0210	DNA helicase
APP7_RS01885	COG0640	Transcriptional regulator
APP7_RS01925	COG2814	Major facilitator Superfamily
APP7_RS01935	COG3381	protein complex oligomerization
APP7_RS01945	COG0791	NLP P60 protein
APP7_RS01950	COG2932	Transcriptional regulator
APP7_RS01955	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
APP7_RS01960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APP7_RS01965	COG2990	Protein conserved in bacteria
APP7_RS01975	COG1643	Atp-dependent helicase
APP7_RS01980	COG2707	UPF0756 membrane protein
APP7_RS01990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APP7_RS01995	COG0534	Mate efflux family protein
APP7_RS02000	COG1074	ATP-dependent DNA helicase activity
APP7_RS02005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APP7_RS02010	COG4535	Mg2 and Co2 transporter CorC
APP7_RS02020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APP7_RS02025	COG2826	transposase and inactivated derivatives, IS30 family
APP7_RS02030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APP7_RS02035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APP7_RS02040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APP7_RS02045	COG2271	Major facilitator Superfamily
APP7_RS02050	COG0584	glycerophosphoryl diester phosphodiesterase
APP7_RS02055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APP7_RS02060	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
APP7_RS02065	COG0247	lactate metabolic process
APP7_RS02095	COG0517	IMP dehydrogenase activity
APP7_RS02095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APP7_RS02105	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APP7_RS02110	COG0385	Bile acid
APP7_RS02115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_RS02120	COG0561	phosphatase activity
APP7_RS02130	COG1595	DNA-templated transcription, initiation
APP7_RS02135	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APP7_RS02145	COG0318	PFAM AMP-dependent synthetase and ligase
APP7_RS02150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APP7_RS02160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APP7_RS02165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APP7_RS02170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APP7_RS02170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APP7_RS02185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APP7_RS02200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APP7_RS02205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APP7_RS02220	COG0750	zinc metalloprotease
APP7_RS02225	COG0575	Belongs to the CDS family
APP7_RS02230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APP7_RS02245	COG0671	phosphoesterase, PA-phosphatase related
APP7_RS02250	COG1534	Rna-binding protein
APP7_RS02255	COG0463	Glycosyl transferase, family 2
APP7_RS02260	COG1686	Belongs to the peptidase S11 family
APP7_RS02265	COG0859	PFAM glycosyl transferase family 9
APP7_RS02275	COG0328	RNA-DNA hybrid ribonuclease activity
APP7_RS02280	COG1286	toxin biosynthetic process
APP7_RS02285	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APP7_RS02295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APP7_RS02300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APP7_RS02310	COG0251	oxidation-reduction process
APP7_RS02315	COG1496	oxidoreductase activity
APP7_RS02325	COG0582	viral genome integration into host DNA
APP7_RS02385	COG3723	Recombinational DNA repair protein, rece pathway
APP7_RS02490	COG3179	chitinase
APP7_RS02520	COG0740	serine-type endopeptidase activity
APP7_RS02605	COG5645	(Lipo)protein
APP7_RS02620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APP7_RS02630	COG1792	Involved in formation and maintenance of cell shape
APP7_RS02635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APP7_RS02640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APP7_RS02645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP7_RS02650	COG0121	glutamine amidotransferase
APP7_RS02655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APP7_RS02660	COG2949	membrane
APP7_RS02670	COG2826	transposase and inactivated derivatives, IS30 family
APP7_RS02680	COG1556	Lactate utilization protein
APP7_RS02685	COG1139	Iron-sulfur cluster binding protein
APP7_RS02690	COG0247	lactate metabolic process
APP7_RS02695	COG1620	l-lactate permease
APP7_RS02700	COG2916	Histone family protein nucleoid-structuring protein H-NS
APP7_RS02705	COG1757	Na H antiporter
APP7_RS02710	COG1879	ABC-type sugar transport system periplasmic component
APP7_RS02715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APP7_RS02725	COG2990	Protein conserved in bacteria
APP7_RS02730	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP7_RS02735	COG0567	Dehydrogenase, E1 component
APP7_RS02740	COG1121	(ABC) transporter
APP7_RS02745	COG0739	heme binding
APP7_RS02750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APP7_RS02755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APP7_RS02765	COG0561	phosphatase activity
APP7_RS02770	COG3850	Histidine kinase
APP7_RS02780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APP7_RS02790	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APP7_RS02800	COG4221	oxidoreductase activity
APP7_RS02825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APP7_RS02825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APP7_RS02835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APP7_RS02845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP7_RS02850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APP7_RS02875	COG0640	Transcriptional regulator
APP7_RS02885	COG0189	ligase activity
APP7_RS02890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APP7_RS02895	COG0280	phosphate acetyltransferase
APP7_RS02895	COG0281	malic enzyme
APP7_RS02905	COG3683	transport system, periplasmic component
APP7_RS02910	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APP7_RS02915	COG1115	amino acid carrier protein
APP7_RS02920	COG1116	anion transmembrane transporter activity
APP7_RS02925	COG1116	anion transmembrane transporter activity
APP7_RS02930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP7_RS02940	COG2104	thiamine diphosphate biosynthetic process
APP7_RS02950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APP7_RS02955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APP7_RS02960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP7_RS02975	COG0481	GTPase activity
APP7_RS02980	COG0681	Belongs to the peptidase S26 family
APP7_RS02985	COG0571	ribonuclease III activity
APP7_RS02990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APP7_RS03080	COG0433	COG0433 Predicted ATPase
APP7_RS03085	COG1840	ABC-type Fe3 transport system, periplasmic component
APP7_RS03100	COG4178	(ABC) transporter
APP7_RS03110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APP7_RS03115	COG2194	sulfuric ester hydrolase activity
APP7_RS03120	COG0528	UMP kinase activity
APP7_RS03125	COG0233	cytoplasmic translational termination
APP7_RS03130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APP7_RS03145	COG0590	tRNA wobble adenosine to inosine editing
APP7_RS03150	COG0513	Belongs to the DEAD box helicase family
APP7_RS03155	COG4785	May be involved in cell division
APP7_RS03160	COG1185	polyribonucleotide nucleotidyltransferase activity
APP7_RS03165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APP7_RS03180	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APP7_RS03195	COG3083	sulfuric ester hydrolase activity
APP7_RS03200	COG3082	Protein of unknown function (DUF1414)
APP7_RS03205	COG1309	transcriptional regulator
APP7_RS03210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_RS03230	COG3955	Domain of unknown function (DUF1919)
APP7_RS03235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APP7_RS03250	COG0517	IMP dehydrogenase activity
APP7_RS03250	COG0516	GMP reductase activity
APP7_RS03255	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APP7_RS03260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APP7_RS03265	COG0814	amino acid
APP7_RS03270	COG0814	amino acid
APP7_RS03280	COG3105	Protein conserved in bacteria
APP7_RS03285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APP7_RS03310	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
APP7_RS03315	COG1823	symporter activity
APP7_RS03320	COG0778	Nitroreductase
APP7_RS03330	COG0072	phenylalanine-tRNA ligase activity
APP7_RS03335	COG0776	regulation of translation
APP7_RS03340	COG0791	NLP P60 protein
APP7_RS03345	COG2801	Transposase and inactivated derivatives
APP7_RS03350	COG2963	transposase activity
APP7_RS03355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APP7_RS03360	COG1846	Transcriptional regulator
APP7_RS03360	COG1940	carbohydrate kinase activity
APP7_RS03365	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APP7_RS03370	COG1522	sequence-specific DNA binding
APP7_RS03375	COG1674	ftsk spoiiie
APP7_RS03380	COG2321	neutral zinc metallopeptidase
APP7_RS03385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APP7_RS03390	COG1214	PFAM Peptidase M22, glycoprotease
APP7_RS03395	COG1435	thymidine kinase activity
APP7_RS03400	COG3074	FtsZ-dependent cytokinesis
APP7_RS03405	COG1494	fructose-1,6-bisphosphatase
APP7_RS03410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APP7_RS03415	COG1136	(ABC) transporter
APP7_RS03415	COG0577	efflux transmembrane transporter activity
APP7_RS03420	COG2205	protein histidine kinase activity
APP7_RS03425	COG0745	RESPONSE REGULATOR receiver
APP7_RS03430	COG3956	TIGRFAM MazG family protein
APP7_RS03440	COG0285	dihydrofolate synthase activity
APP7_RS03450	COG0779	Required for maturation of 30S ribosomal subunits
APP7_RS03455	COG0195	Participates in both transcription termination and antitermination
APP7_RS03460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APP7_RS03465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APP7_RS03470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APP7_RS03475	COG2951	lytic endotransglycosylase activity
APP7_RS03485	COG0857	belongs to the CobB CobQ family
APP7_RS03485	COG0280	phosphate acetyltransferase
APP7_RS03495	COG0737	Belongs to the 5'-nucleotidase family
APP7_RS03515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APP7_RS03525	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APP7_RS03535	COG0589	response to stress
APP7_RS03545	COG2969	positive regulation of protein catabolic process
APP7_RS03550	COG0625	glutathione transferase activity
APP7_RS03555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APP7_RS03565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APP7_RS03570	COG1448	Aminotransferase
APP7_RS03575	COG0006	proline dipeptidase activity
APP7_RS03585	COG1487	ribonuclease activity
APP7_RS03595	COG0556	nucleotide-excision repair
APP7_RS03600	COG2822	iron ion transport
APP7_RS03605	COG2837	iron assimilation
APP7_RS03615	COG0613	PHP domain protein
APP7_RS03625	COG2925	Exonuclease
APP7_RS03630	COG0038	chloride channel
APP7_RS03635	COG0017	Asparaginyl-tRNA synthetase
APP7_RS03640	COG1509	lysine 2,3-aminomutase activity
APP7_RS03650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APP7_RS03655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APP7_RS03660	COG2814	Major facilitator Superfamily
APP7_RS03665	COG0741	lytic transglycosylase activity
APP7_RS03670	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APP7_RS03675	COG0626	cystathionine gamma-synthase activity
APP7_RS03680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APP7_RS03700	COG2363	Small membrane protein
APP7_RS03705	COG0277	FAD linked oxidase domain protein
APP7_RS03710	COG0243	molybdopterin cofactor binding
APP7_RS03715	COG3005	denitrification pathway
APP7_RS03725	COG0315	cyclic pyranopterin monophosphate synthase activity
APP7_RS03730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APP7_RS03735	COG0314	molybdopterin synthase activity
APP7_RS03740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APP7_RS03745	COG1444	tRNA N-acetyltransferase activity
APP7_RS03755	COG0583	DNA-binding transcription factor activity
APP7_RS03780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APP7_RS03785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APP7_RS03800	COG1737	Transcriptional regulator
APP7_RS03805	COG2731	YhcH YjgK YiaL family protein
APP7_RS03810	COG0248	Ppx GppA phosphatase
APP7_RS03820	COG0527	aspartate kinase activity
APP7_RS03825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APP7_RS03830	COG3100	YcgL domain-containing protein
APP7_RS03835	COG0305	Participates in initiation and elongation during chromosome replication
APP7_RS03840	COG4607	ABC-type enterochelin transport system periplasmic component
APP7_RS03845	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP7_RS03850	COG4605	iron ion homeostasis
APP7_RS03855	COG4604	ABC transporter, ATP-binding protein
APP7_RS03860	COG1392	Phosphate transport regulator
APP7_RS03865	COG0306	phosphate transporter
APP7_RS03870	COG4991	sh3 domain protein
APP7_RS03880	COG3945	hemerythrin HHE cation binding domain
APP7_RS03885	COG0343	queuine tRNA-ribosyltransferase activity
APP7_RS03895	COG1278	Cold shock
APP7_RS03900	COG0288	reversible hydration of carbon dioxide
APP7_RS03905	COG0028	Belongs to the TPP enzyme family
APP7_RS03910	COG0440	acetolactate synthase activity
APP7_RS03915	COG0312	modulator of DNA gyrase
APP7_RS03920	COG3028	Belongs to the UPF0307 family
APP7_RS03935	COG1811	Na channel or pump
APP7_RS03940	COG3787	Belongs to the UPF0306 family
APP7_RS03945	COG0023	Translation Initiation Factor
APP7_RS03950	COG0284	orotidine-5'-phosphate decarboxylase activity
APP7_RS03955	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APP7_RS03960	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APP7_RS03965	COG0776	regulation of translation
APP7_RS03970	COG0539	negative regulation of cytoplasmic translation
APP7_RS03990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APP7_RS04000	COG1785	Belongs to the alkaline phosphatase family
APP7_RS04005	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
APP7_RS04015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APP7_RS04015	COG3264	Mechanosensitive ion channel
APP7_RS04020	COG3264	Mechanosensitive ion channel
APP7_RS04020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APP7_RS04025	COG0318	PFAM AMP-dependent synthetase and ligase
APP7_RS04030	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APP7_RS04035	COG0596	Alpha beta hydrolase
APP7_RS04045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APP7_RS04065	COG1380	Effector of murein hydrolase LrgA
APP7_RS04070	COG1346	cytolysis
APP7_RS04075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APP7_RS04085	COG0582	viral genome integration into host DNA
APP7_RS04140	COG4626	Terminase
APP7_RS04140	COG1802	Transcriptional regulator
APP7_RS04185	COG3036	rescue of stalled ribosome
APP7_RS04190	COG2226	methyltransferase
APP7_RS04210	COG0658	competence protein
APP7_RS04210	COG2333	competence protein COMEC
APP7_RS04215	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APP7_RS04220	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APP7_RS04225	COG0737	Belongs to the 5'-nucleotidase family
APP7_RS04245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APP7_RS04250	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP7_RS04255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APP7_RS04265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APP7_RS04280	COG1132	(ABC) transporter
APP7_RS04285	COG1346	cytolysis
APP7_RS04295	COG1199	ATP-dependent helicase activity
APP7_RS04305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APP7_RS04310	COG0629	single-stranded DNA binding
APP7_RS04335	COG2070	2-Nitropropane dioxygenase
APP7_RS04345	COG2315	Protein conserved in bacteria
APP7_RS04350	COG4172	Belongs to the ABC transporter superfamily
APP7_RS04355	COG4171	peptide transport system, permease
APP7_RS04360	COG4168	peptide transport system, permease
APP7_RS04365	COG4166	transmembrane transport
APP7_RS04370	COG3283	Transcriptional regulator of aromatic amino acids metabolism
APP7_RS04375	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APP7_RS04385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APP7_RS04400	COG1368	sulfuric ester hydrolase activity
APP7_RS04405	COG3217	Mosc domain protein beta barrel domain protein
APP7_RS04405	COG0633	Ferredoxin
APP7_RS04410	COG1722	exodeoxyribonuclease VII activity
APP7_RS04415	COG0142	geranyltranstransferase activity
APP7_RS04430	COG1530	ribonuclease E activity
APP7_RS04435	COG1944	ATP diphosphatase activity
APP7_RS04450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APP7_RS04470	COG2351	hydroxyisourate hydrolase activity
APP7_RS04475	COG1609	Transcriptional regulator
APP7_RS04480	COG0586	Pfam SNARE associated Golgi protein
APP7_RS04485	COG0187	DNA topoisomerase II activity
APP7_RS04490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APP7_RS04495	COG1349	DNA-binding transcription factor activity
APP7_RS04500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APP7_RS04505	COG2915	High frequency lysogenization protein hflD homolog
APP7_RS04510	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APP7_RS04515	COG4988	ABC transporter
APP7_RS04520	COG2911	Protein conserved in bacteria
APP7_RS04525	COG0729	surface antigen
APP7_RS04530	COG2861	carbohydrate metabolic process
APP7_RS04535	COG4942	peptidase
APP7_RS04540	COG0588	phosphoglycerate mutase activity
APP7_RS04550	COG0572	uridine kinase
APP7_RS04555	COG0717	Belongs to the dCTP deaminase family
APP7_RS04560	COG1309	transcriptional regulator
APP7_RS04565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_RS04575	COG0842	Transport permease protein
APP7_RS04585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APP7_RS04590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APP7_RS04595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APP7_RS04605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APP7_RS04610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APP7_RS04615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APP7_RS04630	COG0444	Belongs to the ABC transporter superfamily
APP7_RS04635	COG4608	Belongs to the ABC transporter superfamily
APP7_RS04645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APP7_RS04655	COG0747	negative chemotaxis
APP7_RS04660	COG0814	amino acid
APP7_RS04665	COG1760	l-serine dehydratase
APP7_RS04675	COG0134	indole-3-glycerol-phosphate synthase activity
APP7_RS04675	COG0135	phosphoribosylanthranilate isomerase activity
APP7_RS04680	COG3177	Filamentation induced by cAMP protein fic
APP7_RS04685	COG3098	single-species biofilm formation
APP7_RS04690	COG0564	pseudouridine synthase activity
APP7_RS04700	COG3025	triphosphatase activity
APP7_RS04705	COG3106	COG3106 Predicted ATPase
APP7_RS04710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APP7_RS04720	COG1473	amidohydrolase
APP7_RS04725	COG3069	C4-dicarboxylate transmembrane transporter activity
APP7_RS04740	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
APP7_RS04745	COG1466	dna polymerase III delta subunit
APP7_RS04750	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APP7_RS04755	COG0237	dephospho-CoA kinase activity
APP7_RS04765	COG1459	type II secretion system
APP7_RS04770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APP7_RS04775	COG4969	Belongs to the N-Me-Phe pilin family
APP7_RS04780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APP7_RS04790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APP7_RS04795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APP7_RS04800	COG0730	response to heat
APP7_RS04805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APP7_RS04810	COG0183	Belongs to the thiolase family
APP7_RS04815	COG1250	3-hydroxyacyl-CoA dehydrogenase
APP7_RS04815	COG1024	Enoyl-CoA hydratase
APP7_RS04830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APP7_RS04835	COG3383	formate dehydrogenase (NAD+) activity
APP7_RS04835	COG0243	molybdopterin cofactor binding
APP7_RS04840	COG0243	molybdopterin cofactor binding
APP7_RS04840	COG3383	formate dehydrogenase (NAD+) activity
APP7_RS04845	COG0437	4 iron, 4 sulfur cluster binding
APP7_RS04850	COG2864	formate dehydrogenase
APP7_RS04855	COG3058	Necessary for formate dehydrogenase activity
APP7_RS04885	COG1560	Kdo2-lipid A biosynthetic process
APP7_RS04890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APP7_RS04900	COG0302	gtp cyclohydrolase
APP7_RS04905	COG3642	lipopolysaccharide core region biosynthetic process
APP7_RS04915	COG0110	maltose O-acetyltransferase activity
APP7_RS04925	COG0583	DNA-binding transcription factor activity
APP7_RS04945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APP7_RS04955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APP7_RS04960	COG0617	tRNA 3'-terminal CCA addition
APP7_RS04965	COG2963	transposase activity
APP7_RS04970	COG2801	Transposase and inactivated derivatives
APP7_RS04990	COG2975	iron-sulfur cluster assembly
APP7_RS04995	COG0633	Ferredoxin
APP7_RS05015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APP7_RS05025	COG0822	iron-sulfur transferase activity
APP7_RS05030	COG1104	cysteine desulfurase activity
APP7_RS05035	COG1959	2 iron, 2 sulfur cluster binding
APP7_RS05045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APP7_RS05050	COG0784	Response regulator, receiver
APP7_RS05050	COG2198	Histidine kinase
APP7_RS05050	COG5002	protein histidine kinase activity
APP7_RS05055	COG0697	spore germination
APP7_RS05060	COG2840	Smr protein MutS2
APP7_RS05065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APP7_RS05070	COG2226	methyltransferase
APP7_RS05075	COG2830	Protein of unknown function (DUF452)
APP7_RS05080	COG0156	8-amino-7-oxononanoate synthase activity
APP7_RS05085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APP7_RS05095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APP7_RS05100	COG2027	D-alanyl-D-alanine carboxypeptidase
APP7_RS05115	COG2801	Transposase and inactivated derivatives
APP7_RS05135	COG1444	tRNA N-acetyltransferase activity
APP7_RS05140	COG0138	bifunctional purine biosynthesis protein purh
APP7_RS05145	COG2801	Transposase and inactivated derivatives
APP7_RS05165	COG3210	domain, Protein
APP7_RS05170	COG2831	hemolysin activation secretion protein
APP7_RS05175	COG2831	hemolysin activation secretion protein
APP7_RS05185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APP7_RS05205	COG0786	glutamate:sodium symporter activity
APP7_RS05220	COG2350	Protein conserved in bacteria
APP7_RS05225	COG1607	acyl-coa hydrolase
APP7_RS05240	COG3092	negative regulation of chromosome organization
APP7_RS05250	COG2056	Na+-H+ antiporter family
APP7_RS05255	COG0708	Exodeoxyribonuclease III
APP7_RS05260	COG0583	DNA-binding transcription factor activity
APP7_RS05280	COG0254	rRNA binding
APP7_RS05295	COG0753	catalase activity
APP7_RS05300	COG2963	transposase activity
APP7_RS05305	COG2801	Transposase and inactivated derivatives
APP7_RS05310	COG1408	metallophosphoesterase
APP7_RS05315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP7_RS05320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP7_RS05325	COG1085	galactose-1-phosphate uridylyltransferase
APP7_RS05335	COG2017	converts alpha-aldose to the beta-anomer
APP7_RS05365	COG2826	transposase and inactivated derivatives, IS30 family
APP7_RS05380	COG0489	protein tyrosine kinase activity
APP7_RS05390	COG2095	MarC family integral membrane protein
APP7_RS05395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APP7_RS05405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APP7_RS05410	COG2354	Protein conserved in bacteria
APP7_RS05415	COG3071	HemY protein
APP7_RS05420	COG2959	enzyme of heme biosynthesis
APP7_RS05430	COG0181	hydroxymethylbilane synthase activity
APP7_RS05435	COG1012	belongs to the aldehyde dehydrogenase family
APP7_RS05435	COG1454	alcohol dehydrogenase
APP7_RS05450	COG0813	purine-nucleoside phosphorylase activity
APP7_RS05460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APP7_RS05465	COG2364	Membrane
APP7_RS05470	COG0800	Aldolase
APP7_RS05475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP7_RS05480	COG1904	glucuronate isomerase
APP7_RS05490	COG2186	Transcriptional regulator
APP7_RS05500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APP7_RS05500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APP7_RS05505	COG1216	Glycosyl transferase, family 2
APP7_RS05510	COG1216	Glycosyl transferase, family 2
APP7_RS05520	COG3306	glycosyltransferase involved in LPS biosynthesis
APP7_RS05530	COG5039	Polysaccharide pyruvyl transferase
APP7_RS05535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APP7_RS05540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APP7_RS05545	COG1605	Chorismate mutase
APP7_RS05545	COG0077	Prephenate dehydratase
APP7_RS05550	COG0339	signal peptide processing
APP7_RS05555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APP7_RS05560	COG1882	Formate acetyltransferase
APP7_RS05565	COG2116	formate transmembrane transporter activity
APP7_RS05570	COG1238	metal cluster binding
APP7_RS05575	COG0501	Belongs to the peptidase M48B family
APP7_RS05585	COG2431	L-lysine efflux transmembrane transporter activity
APP7_RS05590	COG1169	isochorismate synthase
APP7_RS05595	COG0436	Aminotransferase
APP7_RS05605	COG2962	Rard protein
APP7_RS05610	COG1280	lysine exporter protein (LysE YggA)
APP7_RS05615	COG1629	transport
APP7_RS05615	COG4771	TonB-dependent receptor
APP7_RS05620	COG0748	coenzyme F420 binding
APP7_RS05630	COG3088	subunit of a heme lyase
APP7_RS05630	COG4235	cytochrome complex assembly
APP7_RS05635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP7_RS05640	COG1138	Cytochrome C-type biogenesis protein
APP7_RS05655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APP7_RS05660	COG2963	transposase activity
APP7_RS05665	COG2963	transposase activity
APP7_RS05670	COG2801	Transposase and inactivated derivatives
APP7_RS05675	COG2801	Transposase and inactivated derivatives
APP7_RS05680	COG3111	PFAM Bacterial OB fold (BOF) protein
APP7_RS05695	COG0745	RESPONSE REGULATOR receiver
APP7_RS05700	COG0642	Histidine kinase
APP7_RS05705	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APP7_RS05710	COG1862	Preprotein translocase
APP7_RS05715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APP7_RS05720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APP7_RS05725	COG1528	Iron-storage protein
APP7_RS05730	COG1528	Iron-storage protein
APP7_RS05735	COG2252	PERMEase
APP7_RS05740	COG0424	maF-like protein
APP7_RS05750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP7_RS05750	COG0301	tRNA thio-modification
APP7_RS05760	COG0330	HflC and HflK could
APP7_RS05765	COG0330	HflC and HflK could
APP7_RS05770	COG3118	belongs to the thioredoxin family
APP7_RS05790	COG0531	amino acid
APP7_RS05795	COG0531	amino acid
APP7_RS05810	COG3047	cAMP biosynthetic process
APP7_RS05820	COG0798	PFAM Bile acid sodium symporter
APP7_RS05825	COG1393	Belongs to the ArsC family
APP7_RS05835	COG1027	Aspartate ammonia-lyase
APP7_RS05845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APP7_RS05850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APP7_RS05850	COG3064	Membrane
APP7_RS05850	COG3583	domain protein
APP7_RS05860	COG0720	synthase
APP7_RS05865	COG0602	queuosine metabolic process
APP7_RS05890	COG0795	lipopolysaccharide-transporting ATPase activity
APP7_RS05895	COG0795	lipopolysaccharide-transporting ATPase activity
APP7_RS05905	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APP7_RS05920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APP7_RS05940	COG0861	Integral membrane protein TerC family
APP7_RS05945	COG1472	Belongs to the glycosyl hydrolase 3 family
APP7_RS05950	COG2826	transposase and inactivated derivatives, IS30 family
APP7_RS05960	COG0148	phosphopyruvate hydratase activity
APP7_RS05965	COG1051	belongs to the nudix hydrolase family
APP7_RS05970	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
APP7_RS05995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APP7_RS06000	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APP7_RS06005	COG0564	pseudouridine synthase activity
APP7_RS06015	COG0205	6-phosphofructokinase activity
APP7_RS06020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APP7_RS06025	COG1525	nuclease
APP7_RS06030	COG1115	amino acid carrier protein
APP7_RS06035	COG0628	permease
APP7_RS06045	COG0826	peptidase U32
APP7_RS06050	COG3307	-O-antigen
APP7_RS06055	COG1519	Transferase
APP7_RS06065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APP7_RS06070	COG0802	atpase or kinase
APP7_RS06075	COG1388	LysM domain
APP7_RS06075	COG0860	N-Acetylmuramoyl-L-alanine amidase
APP7_RS06080	COG0166	Belongs to the GPI family
APP7_RS06085	COG2960	long-chain fatty acid transporting porin activity
APP7_RS06110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APP7_RS06130	COG2137	regulation of response to DNA damage stimulus
APP7_RS06135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APP7_RS06140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APP7_RS06150	COG1322	Protein conserved in bacteria
APP7_RS06155	COG0512	Glutamine amidotransferase of anthranilate synthase
APP7_RS06170	COG0494	nUDIX hydrolase
APP7_RS06175	COG0217	transcriptional regulatory protein
APP7_RS06185	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APP7_RS06190	COG0612	Peptidase, M16
APP7_RS06200	COG0471	metal ion transport
APP7_RS06205	COG0583	DNA-binding transcription factor activity
APP7_RS06210	COG3266	domain, Protein
APP7_RS06215	COG1187	pseudouridine synthase activity
APP7_RS06220	COG0009	L-threonylcarbamoyladenylate synthase
APP7_RS06230	COG2837	iron assimilation
APP7_RS06235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APP7_RS06240	COG0512	Glutamine amidotransferase of anthranilate synthase
APP7_RS06250	COG2226	methyltransferase
APP7_RS06255	COG2268	Band 7 protein
APP7_RS06260	COG2841	Protein conserved in bacteria
APP7_RS06275	COG2965	DNA replication, synthesis of RNA primer
APP7_RS06290	COG3201	nicotinamide mononucleotide transporter
APP7_RS06295	COG2976	Protein conserved in bacteria
APP7_RS06305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APP7_RS06310	COG1426	Protein conserved in bacteria
APP7_RS06315	COG0659	secondary active sulfate transmembrane transporter activity
APP7_RS06325	COG0673	inositol 2-dehydrogenase activity
APP7_RS06330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APP7_RS06330	COG0475	glutathione-regulated potassium exporter activity
APP7_RS06360	COG2207	Transcriptional regulator
APP7_RS06370	COG1902	pentaerythritol trinitrate reductase activity
APP7_RS06375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APP7_RS06380	COG2084	Dehydrogenase
APP7_RS06385	COG0778	Nitroreductase
APP7_RS06390	COG2095	MarC family integral membrane protein
APP7_RS06405	COG0625	glutathione transferase activity
APP7_RS06420	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APP7_RS06425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APP7_RS06440	COG1275	C4-dicarboxylate transporter malic acid transport protein
APP7_RS06445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APP7_RS06455	COG1132	(ABC) transporter
APP7_RS06460	COG1854	S-ribosylhomocysteine lyase activity
APP7_RS06465	COG3008	intermembrane lipid transfer
APP7_RS06470	COG0735	belongs to the Fur family
APP7_RS06475	COG0716	FMN binding
APP7_RS06485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APP7_RS06490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APP7_RS06495	COG2252	PERMEase
APP7_RS06500	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APP7_RS06505	COG2081	HI0933 family
APP7_RS06510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APP7_RS06520	COG0560	Phosphoserine phosphatase
APP7_RS06535	COG0058	SHG alpha-glucan phosphorylase activity
APP7_RS06540	COG2909	trisaccharide binding
APP7_RS06550	COG4580	involved in the transport of maltose and maltodextrins
APP7_RS06555	COG3842	ATPase activity
APP7_RS06570	COG3833	ABC-type maltose transport systems, permease component
APP7_RS06575	COG1640	4-alpha-glucanotransferase
APP7_RS06580	COG1966	Carbon starvation protein
APP7_RS06585	COG0084	hydrolase, TatD family'
APP7_RS06590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APP7_RS06600	COG0778	Nitroreductase
APP7_RS06615	COG4172	Belongs to the ABC transporter superfamily
APP7_RS06620	COG0191	fructose-bisphosphate aldolase activity
APP7_RS06625	COG0126	phosphoglycerate kinase activity
APP7_RS06630	COG0471	metal ion transport
APP7_RS06635	COG0471	metal ion transport
APP7_RS06640	COG0471	metal ion transport
APP7_RS06645	COG0187	DNA topoisomerase II activity
APP7_RS06650	COG5002	protein histidine kinase activity
APP7_RS06655	COG0745	RESPONSE REGULATOR receiver
APP7_RS06680	COG0789	Transcriptional regulator
APP7_RS06700	COG0300	oxidoreductase activity
APP7_RS06705	COG0778	Nitroreductase
APP7_RS06710	COG0616	signal peptide processing
APP7_RS06715	COG3719	Belongs to the RNase T2 family
APP7_RS06725	COG1252	NADH dehydrogenase
APP7_RS06730	COG2183	response to ionizing radiation
APP7_RS06735	COG3063	Type IV pilus biogenesis stability protein PilW
APP7_RS06775	COG2161	toxin-antitoxin pair type II binding
APP7_RS06780	COG4115	mRNA cleavage
APP7_RS06785	COG2835	tetraacyldisaccharide 4'-kinase activity
APP7_RS06795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APP7_RS06805	COG2166	iron-sulfur cluster assembly
APP7_RS06825	COG0488	(ABC) transporter
APP7_RS06830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APP7_RS06850	COG5007	Belongs to the BolA IbaG family
APP7_RS06860	COG2854	intermembrane phospholipid transfer
APP7_RS06865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APP7_RS06870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APP7_RS06875	COG1127	ABC transporter
APP7_RS06880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APP7_RS06885	COG1090	epimerase
APP7_RS06915	COG2814	Major facilitator Superfamily
APP7_RS06945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APP7_RS06955	COG1794	racemase activity, acting on amino acids and derivatives
APP7_RS06960	COG2814	Major facilitator Superfamily
APP7_RS06965	COG0363	glucosamine-6-phosphate deaminase activity
APP7_RS06970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APP7_RS06975	COG1218	3'(2'),5'-bisphosphate nucleotidase
APP7_RS06980	COG0494	nUDIX hydrolase
APP7_RS06985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APP7_RS06995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APP7_RS07005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APP7_RS07020	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APP7_RS07025	COG1178	ABC-type Fe3 transport system permease component
APP7_RS07030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_RS07035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APP7_RS07040	COG2190	(PTS) system
APP7_RS07045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APP7_RS07050	COG0210	DNA helicase
APP7_RS07055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APP7_RS07060	COG0409	Hydrogenase expression formation protein
APP7_RS07065	COG0309	Hydrogenase expression formation protein (HypE)
APP7_RS07070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APP7_RS07075	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APP7_RS07080	COG0437	4 iron, 4 sulfur cluster binding
APP7_RS07085	COG5557	Pfam Polysulphide reductase, NrfD
APP7_RS07090	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APP7_RS07095	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APP7_RS07100	COG1773	rubredoxin
APP7_RS07105	COG0298	carbon dioxide binding
APP7_RS07110	COG0375	protein maturation
APP7_RS07145	COG0308	aminopeptidase N
APP7_RS07150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APP7_RS07155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APP7_RS07160	COG0295	cytidine deaminase activity
APP7_RS07165	COG2177	Part of the ABC transporter FtsEX involved in
APP7_RS07170	COG2884	Cell division ATP-binding protein ftsE
APP7_RS07175	COG0552	protein localization to endoplasmic reticulum
APP7_RS07180	COG0742	ribosomal rna small subunit methyltransferase
APP7_RS07185	COG3099	Belongs to the UPF0263 family
APP7_RS07190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APP7_RS07200	COG4160	amino acid transport
APP7_RS07205	COG4215	(ABC) transporter
APP7_RS07210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APP7_RS07215	COG1126	abc transporter atp-binding protein
APP7_RS07220	COG1881	PFAM PEBP family protein
APP7_RS07230	COG3620	sequence-specific DNA binding
APP7_RS07240	COG4232	protein-disulfide reductase activity
APP7_RS07245	COG3101	peptidyl-lysine hydroxylation
APP7_RS07255	COG3107	peptidoglycan biosynthetic process
APP7_RS07260	COG0792	nuclease activity
APP7_RS07265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APP7_RS07295	COG1138	Cytochrome C-type biogenesis protein
APP7_RS07305	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP7_RS07310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP7_RS07315	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP7_RS07320	COG4133	protoheme IX ABC transporter activity
APP7_RS07325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APP7_RS07365	COG3630	sodium ion export across plasma membrane
APP7_RS07375	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APP7_RS07380	COG2824	Alkylphosphonate utilization operon protein PhnA
APP7_RS07385	COG1858	cytochrome C peroxidase
APP7_RS07395	COG0762	integral membrane protein
APP7_RS07400	COG3171	Protein conserved in bacteria
APP7_RS07405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APP7_RS07410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APP7_RS07415	COG0416	fatty acid biosynthetic process
APP7_RS07425	COG1399	metal-binding, possibly nucleic acid-binding protein
APP7_RS07430	COG4137	Cytochrome C assembly protein
APP7_RS07435	COG4536	flavin adenine dinucleotide binding
APP7_RS07440	COG0733	neurotransmitter:sodium symporter activity
APP7_RS07450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP7_RS07450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_RS07455	COG3715	PTS system
APP7_RS07460	COG3716	PTS system mannose fructose sorbose family IID component
APP7_RS07495	COG1840	ABC-type Fe3 transport system, periplasmic component
APP7_RS07510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APP7_RS07525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APP7_RS07530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APP7_RS07550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APP7_RS07560	COG1720	tRNA m6t6A37 methyltransferase activity
APP7_RS07565	COG4804	nuclease activity
APP7_RS07570	COG1575	Belongs to the MenA family. Type 1 subfamily
APP7_RS07580	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APP7_RS07585	COG1088	dTDP-glucose 4,6-dehydratase activity
APP7_RS07610	COG1215	transferase activity, transferring glycosyl groups
APP7_RS07630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APP7_RS07635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APP7_RS07645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APP7_RS07650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APP7_RS07660	COG0557	exoribonuclease II activity
APP7_RS07665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP7_RS07670	COG1309	transcriptional regulator
APP7_RS07675	COG0583	DNA-binding transcription factor activity
APP7_RS07680	COG0678	peroxiredoxin activity
APP7_RS07680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APP7_RS07690	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APP7_RS07700	COG1755	Isoprenylcysteine carboxyl methyltransferase
APP7_RS07710	COG1530	ribonuclease E activity
APP7_RS07720	COG2963	transposase activity
APP7_RS07730	COG2249	NAD(P)H dehydrogenase (quinone) activity
APP7_RS07735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APP7_RS07745	COG0243	molybdopterin cofactor binding
APP7_RS07750	COG0437	4 iron, 4 sulfur cluster binding
APP7_RS07755	COG0348	domain, Protein
APP7_RS07760	COG3043	anaerobic respiration
APP7_RS07765	COG3005	denitrification pathway
APP7_RS07775	COG2050	protein possibly involved in aromatic compounds catabolism
APP7_RS07780	COG0247	lactate metabolic process
APP7_RS07780	COG0277	FAD linked oxidase domain protein
APP7_RS07790	COG1879	ABC-type sugar transport system periplasmic component
APP7_RS07795	COG1129	ABC transporter
APP7_RS07800	COG4211	Belongs to the binding-protein-dependent transport system permease family
APP7_RS07825	COG1022	Amp-dependent synthetase and ligase
APP7_RS07830	COG4989	oxidoreductase activity
APP7_RS07835	COG3691	Protein conserved in bacteria
APP7_RS07840	COG0814	amino acid
APP7_RS07850	COG2918	glutathione biosynthetic process
APP7_RS07850	COG1181	Belongs to the D-alanine--D-alanine ligase family
APP7_RS07860	COG4974	Belongs to the 'phage' integrase family
APP7_RS07865	COG0732	type I restriction modification DNA specificity domain
APP7_RS07890	COG1555	photosystem II stabilization
APP7_RS07895	COG3061	Opacity-associated protein A
APP7_RS07895	COG3266	domain, Protein
APP7_RS07905	COG0859	PFAM glycosyl transferase family 9
APP7_RS07910	COG0859	PFAM glycosyl transferase family 9
APP7_RS07915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APP7_RS07920	COG0049	tRNA binding
APP7_RS07925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APP7_RS07930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APP7_RS07945	COG2801	Transposase and inactivated derivatives
APP7_RS07965	COG0825	malonyl-CoA metabolic process
APP7_RS07975	COG0204	Acyl-transferase
APP7_RS07980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APP7_RS08005	COG0783	Belongs to the Dps family
APP7_RS08020	COG1289	transmembrane transporter activity
APP7_RS08025	COG1803	Methylglyoxal synthase
APP7_RS08030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APP7_RS08035	COG2963	transposase activity
APP7_RS08040	COG2801	Transposase and inactivated derivatives
APP7_RS08055	COG2153	protein acetylation
APP7_RS08060	COG2927	DNA polymerase III (CHI subunit)
APP7_RS08065	COG1652	LysM domain
APP7_RS08075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP7_RS08085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APP7_RS08090	COG1045	serine acetyltransferase
APP7_RS08095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APP7_RS08125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP7_RS08140	COG0521	Mo-molybdopterin cofactor biosynthetic process
APP7_RS08150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APP7_RS08160	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APP7_RS08175	COG0625	glutathione transferase activity
APP7_RS08180	COG0019	diaminopimelate decarboxylase activity
APP7_RS08190	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APP7_RS08195	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APP7_RS08200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APP7_RS08205	COG1053	succinate dehydrogenase
APP7_RS08210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APP7_RS08220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APP7_RS08225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APP7_RS08275	COG4974	Belongs to the 'phage' integrase family
APP7_RS08335	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APP7_RS08355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APP7_RS08360	COG2244	polysaccharide biosynthetic process
APP7_RS08365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APP7_RS08375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APP7_RS08380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APP7_RS08385	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APP7_RS08405	COG0728	peptidoglycan biosynthetic process
APP7_RS08410	COG0268	Binds directly to 16S ribosomal RNA
APP7_RS08415	COG0569	domain protein
APP7_RS08420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APP7_RS08425	COG3276	selenocysteine insertion sequence binding
APP7_RS08440	COG0716	FMN binding
APP7_RS08460	COG1629	transport
APP7_RS08460	COG4771	TonB-dependent receptor
APP7_RS08485	COG2431	L-lysine efflux transmembrane transporter activity
APP7_RS08490	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APP7_RS08520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APP7_RS08530	COG2826	transposase and inactivated derivatives, IS30 family
APP7_RS08555	COG1119	ATPase activity
APP7_RS08570	COG1739	Uncharacterized protein family UPF0029
APP7_RS08575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APP7_RS08580	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APP7_RS08585	COG1970	mechanosensitive ion channel activity
APP7_RS08590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APP7_RS08595	COG0321	lipoyl(octanoyl) transferase activity
APP7_RS08600	COG2921	Belongs to the UPF0250 family
APP7_RS08605	COG1686	Belongs to the peptidase S11 family
APP7_RS08610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APP7_RS08615	COG0772	Belongs to the SEDS family
APP7_RS08620	COG0768	penicillin binding
APP7_RS08625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APP7_RS08630	COG0799	negative regulation of ribosome biogenesis
APP7_RS08640	COG1126	abc transporter atp-binding protein
APP7_RS08645	COG0765	amino acid transport
APP7_RS08650	COG3681	Belongs to the UPF0597 family
APP7_RS08655	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
APP7_RS08665	COG3691	Protein conserved in bacteria
APP7_RS08715	COG0831	urea catabolic process
APP7_RS08725	COG1122	ATPase activity
APP7_RS08730	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APP7_RS08740	COG0310	cobalt ion transport
APP7_RS08745	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
APP7_RS08750	COG0583	DNA-binding transcription factor activity
APP7_RS08760	COG0490	domain, Protein
APP7_RS08760	COG0471	metal ion transport
APP7_RS08765	COG3722	fumarate hydratase activity
APP7_RS08780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APP7_RS08785	COG1349	DNA-binding transcription factor activity
APP7_RS08810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APP7_RS08815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APP7_RS08820	COG2900	Belongs to the SlyX family
APP7_RS08825	COG0545	Peptidyl-prolyl cis-trans isomerase
APP7_RS08830	COG2964	Protein conserved in bacteria
APP7_RS08835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APP7_RS08845	COG2168	tRNA wobble position uridine thiolation
APP7_RS08875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APP7_RS08880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APP7_RS08890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APP7_RS08925	COG0561	phosphatase activity
APP7_RS08930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APP7_RS08935	COG3012	SEC-C Motif Domain Protein
APP7_RS08945	COG3716	PTS system mannose fructose sorbose family IID component
APP7_RS08950	COG3715	PTS system
APP7_RS08955	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP7_RS08955	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_RS08960	COG2610	gluconate transmembrane transporter activity
APP7_RS08965	COG3265	gluconokinase activity
APP7_RS08970	COG1609	Transcriptional regulator
APP7_RS08990	COG1172	Belongs to the binding-protein-dependent transport system permease family
APP7_RS08995	COG1879	ABC-type sugar transport system periplasmic component
APP7_RS09000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP7_RS09005	COG0243	molybdopterin cofactor binding
APP7_RS09010	COG0437	4 iron, 4 sulfur cluster binding
APP7_RS09015	COG3302	dmso reductase anchor subunit
APP7_RS09020	COG3381	protein complex oligomerization
APP7_RS09025	COG2221	Nitrite and sulphite reductase 4Fe-4S
APP7_RS09025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APP7_RS09055	COG1349	DNA-binding transcription factor activity
APP7_RS09060	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
APP7_RS09065	COG1070	Carbohydrate kinase
APP7_RS09070	COG4154	Belongs to the RbsD FucU family
APP7_RS09075	COG0235	Class ii aldolase
APP7_RS09080	COG0738	Major facilitator superfamily
APP7_RS09085	COG1454	alcohol dehydrogenase
APP7_RS09090	COG3477	response to acidic pH
APP7_RS09095	COG0765	amino acid transport
APP7_RS09105	COG1126	abc transporter atp-binding protein
APP7_RS09110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APP7_RS09130	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APP7_RS09155	COG3623	hexulose-6-phosphate isomerase
APP7_RS09160	COG0235	Class ii aldolase
APP7_RS09165	COG0545	Peptidyl-prolyl cis-trans isomerase
APP7_RS09185	COG4783	chaperone-mediated protein folding
APP7_RS09200	COG0758	DNA mediated transformation
APP7_RS09205	COG1297	OPT oligopeptide transporter protein
APP7_RS09220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APP7_RS09230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APP7_RS09235	COG0081	regulation of translation
APP7_RS09240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APP7_RS09245	COG0222	ribosome binding
APP7_RS09280	COG0085	RNA polymerase activity
APP7_RS09300	COG1487	ribonuclease activity
APP7_RS09320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APP7_RS09325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APP7_RS09330	COG1489	DNA binding
APP7_RS09335	COG0346	lactoylglutathione lyase activity
APP7_RS09340	COG1194	a g-specific adenine glycosylase
APP7_RS09345	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APP7_RS09350	COG0741	lytic transglycosylase activity
APP7_RS09385	COG0305	Participates in initiation and elongation during chromosome replication
APP7_RS09460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APP7_RS09475	COG0737	Belongs to the 5'-nucleotidase family
APP7_RS09480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP7_RS09485	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APP7_RS09490	COG0606	chelatase, subunit chli
APP7_RS09500	COG0210	DNA helicase
APP7_RS09530	COG0640	Transcriptional regulator
APP7_RS09570	COG0606	chelatase, subunit chli
APP7_RS09580	COG2267	carboxylic ester hydrolase activity
APP7_RS09595	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APP7_RS09605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APP7_RS09610	COG0363	glucosamine-6-phosphate deaminase activity
APP7_RS09615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APP7_RS09630	COG0051	transcription antitermination factor activity, RNA binding
APP7_RS09635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APP7_RS09640	COG0088	Forms part of the polypeptide exit tunnel
APP7_RS09645	COG0089	rRNA binding
APP7_RS09650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APP7_RS09655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APP7_RS09660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APP7_RS09665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APP7_RS09670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APP7_RS09675	COG0255	Belongs to the universal ribosomal protein uL29 family
APP7_RS09680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APP7_RS09690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APP7_RS09695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APP7_RS09700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APP7_RS09705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APP7_RS09710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APP7_RS09715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APP7_RS09720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APP7_RS09725	COG1841	ribosomal large subunit assembly
APP7_RS09735	COG0201	protein transport
APP7_RS09745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APP7_RS09750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APP7_RS09755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APP7_RS09760	COG0202	RNA polymerase activity
APP7_RS09770	COG0228	four-way junction DNA binding
APP7_RS09775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APP7_RS09780	COG0336	Belongs to the RNA methyltransferase TrmD family
APP7_RS09785	COG0335	large ribosomal subunit rRNA binding
APP7_RS09790	COG2850	peptidyl-arginine hydroxylation
APP7_RS09795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP7_RS09800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP7_RS09845	COG2852	Protein conserved in bacteria
APP7_RS09860	COG4106	trans-aconitate 2-methyltransferase activity
APP7_RS09875	COG2832	Protein of unknown function (DUF454)
APP7_RS09885	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APP7_RS09895	COG0084	hydrolase, TatD family'
APP7_RS09910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_RS09920	COG0470	DNA polymerase III
APP7_RS09925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APP7_RS09930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APP7_RS09950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APP7_RS09955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APP7_RS09960	COG0254	rRNA binding
APP7_RS09965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APP7_RS09970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP7_RS09975	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APP7_RS09990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APP7_RS10015	COG1595	DNA-templated transcription, initiation
APP7_RS10020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APP7_RS10030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APP7_RS10050	COG2502	aspartate--ammonia ligase
APP7_RS10055	COG1522	sequence-specific DNA binding
APP7_RS10060	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APP7_RS10100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APP7_RS10125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APP7_RS10135	COG4208	sulfate ABC transporter
APP7_RS10140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APP7_RS10145	COG1304	FMN binding
APP7_RS10150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APP7_RS10150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APP7_RS10155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APP7_RS10170	COG2995	paraquat-inducible protein a
APP7_RS10175	COG1305	Transglutaminase-like
APP7_RS10185	COG2608	mercury ion transmembrane transporter activity
APP7_RS10190	COG1979	alcohol dehydrogenase
APP7_RS10195	COG0583	DNA-binding transcription factor activity
APP7_RS10200	COG2171	N-acyltransferase activity
APP7_RS10205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APP7_RS10215	COG0511	ligase activity, forming carbon-carbon bonds
APP7_RS10220	COG0439	Biotin carboxylase
APP7_RS10230	COG3084	Protein conserved in bacteria
APP7_RS10235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APP7_RS10240	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APP7_RS10240	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APP7_RS10245	COG0742	ribosomal rna small subunit methyltransferase
APP7_RS10250	COG1876	peptidase activity
APP7_RS10255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APP7_RS10260	COG1393	Belongs to the ArsC family
APP7_RS10270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APP7_RS10275	COG0564	pseudouridine synthase activity
APP7_RS10285	COG0668	transmembrane transport
APP7_RS10290	COG0439	Biotin carboxylase
APP7_RS10300	COG1025	Belongs to the peptidase M16 family
APP7_RS10305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APP7_RS10330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APP7_RS10335	COG1067	ATP-dependent peptidase activity
APP7_RS10340	COG3120	sequence-specific DNA binding
APP7_RS10345	COG0180	Tryptophanyl-tRNA synthetase
APP7_RS10350	COG0546	phosphoglycolate phosphatase activity
APP7_RS10365	COG0730	response to heat
APP7_RS10380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APP7_RS10395	COG2116	formate transmembrane transporter activity
APP7_RS10405	COG2801	Transposase and inactivated derivatives
APP7_RS10410	COG2801	Transposase and inactivated derivatives
APP7_RS10415	COG2963	transposase activity
APP7_RS10435	COG1070	Carbohydrate kinase
APP7_RS10440	COG2115	Belongs to the xylose isomerase family
APP7_RS10445	COG4213	ABC transporter substrate-binding protein
APP7_RS10450	COG1129	ABC transporter
APP7_RS10455	COG4214	carbohydrate transport
APP7_RS10460	COG2207	Transcriptional regulator
APP7_RS10460	COG1609	Transcriptional regulator
APP7_RS10465	COG3590	peptidase
APP7_RS10475	COG4145	pantothenate transmembrane transporter activity
APP7_RS10480	COG3924	membrane
APP7_RS10485	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
APP7_RS10490	COG2853	Lipoprotein
APP7_RS10495	COG0676	glucose-6-phosphate 1-epimerase activity
APP7_RS10510	COG0726	polysaccharide deacetylase
APP7_RS10510	COG1649	PFAM Uncharacterised BCR, COG1649
APP7_RS10515	COG1215	transferase activity, transferring glycosyl groups
APP7_RS10525	COG0149	triose-phosphate isomerase activity
APP7_RS10535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APP7_RS10540	COG1238	metal cluster binding
APP7_RS10555	COG4942	peptidase
APP7_RS10555	COG1388	LysM domain
APP7_RS10560	COG2818	Glycosylase
APP7_RS10570	COG0700	Nucleoside recognition
APP7_RS10575	COG3366	ferrous iron transmembrane transporter activity
APP7_RS10585	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APP7_RS10590	COG0594	ribonuclease P activity
APP7_RS10595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APP7_RS10600	COG0174	glutamine synthetase
APP7_RS10605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APP7_RS10610	COG0494	nUDIX hydrolase
APP7_RS10640	COG1490	D-aminoacyl-tRNA deacylase activity
APP7_RS10645	COG1295	ribonuclease BN
APP7_RS10685	COG1064	alcohol dehydrogenase
APP7_RS10695	COG1923	regulation of RNA biosynthetic process
APP7_RS10700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APP7_RS10705	COG1611	Belongs to the LOG family
APP7_RS10710	COG1694	Mazg nucleotide pyrophosphohydrolase
APP7_RS10725	COG1309	transcriptional regulator
APP7_RS10735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APP7_RS10740	COG2003	Belongs to the UPF0758 family
APP7_RS10745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APP7_RS10750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APP7_RS10765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APP7_RS10770	COG0076	glutamate decarboxylase activity
APP7_RS10775	COG0425	Belongs to the sulfur carrier protein TusA family
APP7_RS10780	COG2391	methyltransferase activity
APP7_RS10785	COG3085	chromosome segregation
APP7_RS10805	COG0598	Magnesium transport protein CorA
APP7_RS10810	COG2226	methyltransferase
APP7_RS10825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APP7_RS10830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APP7_RS10835	COG0805	protein transport
APP7_RS10855	COG1114	Component of the transport system for branched-chain amino acids
APP7_RS10860	COG1028	Short-chain dehydrogenase reductase Sdr
APP7_RS10865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APP7_RS10870	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APP7_RS10875	COG0142	geranyltranstransferase activity
APP7_RS10885	COG0431	NADPH-dependent FMN reductase
APP7_RS10890	COG2259	Doxx family
APP7_RS10900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APP7_RS10905	COG0697	spore germination
APP7_RS10910	COG4783	chaperone-mediated protein folding
APP7_RS10920	COG1040	competence protein
APP7_RS10935	COG0456	acetyltransferase
APP7_RS10940	COG0513	Belongs to the DEAD box helicase family
APP7_RS10950	COG0747	negative chemotaxis
APP7_RS10960	COG1584	GPR1 FUN34 yaaH family protein
APP7_RS10965	COG1120	ATPase activity
APP7_RS10970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP7_RS10975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP7_RS11000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APP7_RS11005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APP7_RS11025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APP7_RS11040	COG0140	phosphoribosyl-ATP diphosphatase activity
APP7_RS11040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APP7_RS11045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APP7_RS11050	COG0024	Methionine aminopeptidase
APP7_RS11065	COG1621	beta-fructofuranosidase activity
APP7_RS11070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP7_RS11080	COG4591	ABC-type transport system involved in lipoprotein release permease component
APP7_RS11085	COG1136	(ABC) transporter
APP7_RS11090	COG4591	ABC-type transport system involved in lipoprotein release permease component
APP7_RS11095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APP7_RS11205	COG5295	Hep Hag repeat protein
APP7_RS11205	COG5295	Hep Hag repeat protein
APP7_RS11205	COG5295	Hep Hag repeat protein