locus-tag	class	description
IMCC25003_RS00005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IMCC25003_RS00010	COG2177	Part of the ABC transporter FtsEX involved in
IMCC25003_RS00015	COG2884	Cell division ATP-binding protein ftsE
IMCC25003_RS00020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IMCC25003_RS00070	COG0508	dehydrogenase complex catalyzes the overall conversion of
IMCC25003_RS00070	COG0567	Dehydrogenase, E1 component
IMCC25003_RS00075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IMCC25003_RS00100	COG1595	DNA-templated transcription, initiation
IMCC25003_RS00105	COG2135	peptidase activity
IMCC25003_RS00110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IMCC25003_RS00115	COG1162	GTPase activity
IMCC25003_RS00120	COG0483	inositol monophosphate 1-phosphatase activity
IMCC25003_RS00130	COG1183	phosphatidylcholine synthase activity
IMCC25003_RS00145	COG1615	UPF0182 protein
IMCC25003_RS00150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IMCC25003_RS00200	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IMCC25003_RS00210	COG0210	DNA helicase
IMCC25003_RS00215	COG1217	gtp-binding protein TYPA
IMCC25003_RS00220	COG0012	GTP binding
IMCC25003_RS00240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IMCC25003_RS00245	COG1570	exodeoxyribonuclease VII activity
IMCC25003_RS00250	COG1722	exodeoxyribonuclease VII activity
IMCC25003_RS00255	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IMCC25003_RS00255	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IMCC25003_RS00265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IMCC25003_RS00285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IMCC25003_RS00350	COG0148	phosphopyruvate hydratase activity
IMCC25003_RS00370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IMCC25003_RS00375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IMCC25003_RS00380	COG0193	aminoacyl-tRNA hydrolase activity
IMCC25003_RS00385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IMCC25003_RS00390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IMCC25003_RS00395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IMCC25003_RS00410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IMCC25003_RS00415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IMCC25003_RS00420	COG0084	hydrolase, TatD family'
IMCC25003_RS00425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMCC25003_RS00455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IMCC25003_RS00460	COG1960	acyl-CoA dehydrogenase activity
IMCC25003_RS00480	COG2409	Drug exporters of the RND superfamily
IMCC25003_RS00485	COG0788	formyltetrahydrofolate deformylase activity
IMCC25003_RS00505	COG0300	oxidoreductase activity
IMCC25003_RS00510	COG0513	Belongs to the DEAD box helicase family
IMCC25003_RS00520	COG5002	protein histidine kinase activity
IMCC25003_RS00520	COG5001	Diguanylate cyclase
IMCC25003_RS00520	COG3447	MASE1 domain protein
IMCC25003_RS00525	COG0415	Belongs to the DNA photolyase family
IMCC25003_RS00535	COG0259	pyridoxamine-phosphate oxidase activity
IMCC25003_RS00540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IMCC25003_RS00570	COG0459	protein refolding
IMCC25003_RS00580	COG0702	epimerase
IMCC25003_RS00585	COG1252	NADH dehydrogenase
IMCC25003_RS00590	COG0596	Alpha beta hydrolase
IMCC25003_RS00605	COG3250	beta-galactosidase activity
IMCC25003_RS00620	COG0215	cysteine-tRNA ligase activity
IMCC25003_RS00625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IMCC25003_RS00625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IMCC25003_RS00630	COG1329	Transcriptional regulator
IMCC25003_RS00640	COG0588	phosphoglycerate mutase activity
IMCC25003_RS00650	COG0438	transferase activity, transferring glycosyl groups
IMCC25003_RS00660	COG4044	May play a role in the intracellular transport of hydrophobic ligands
IMCC25003_RS00675	COG0735	belongs to the Fur family
IMCC25003_RS00700	COG0745	RESPONSE REGULATOR receiver
IMCC25003_RS00705	COG0456	acetyltransferase
IMCC25003_RS00710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IMCC25003_RS00725	COG4702	Belongs to the UPF0303 family
IMCC25003_RS00790	COG1216	Glycosyl transferase, family 2
IMCC25003_RS00830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IMCC25003_RS00835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IMCC25003_RS00835	COG2755	lipolytic protein G-D-S-L family
IMCC25003_RS00845	COG0463	Glycosyl transferase, family 2
IMCC25003_RS00870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IMCC25003_RS00875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IMCC25003_RS00880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IMCC25003_RS00885	COG3959	Transketolase, thiamine diphosphate binding domain
IMCC25003_RS00895	COG0470	DNA polymerase III
IMCC25003_RS00900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IMCC25003_RS00910	COG1754	DNA topoisomerase type I activity
IMCC25003_RS00910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IMCC25003_RS00915	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IMCC25003_RS00920	COG2723	6-phospho-beta-galactosidase activity
IMCC25003_RS00925	COG0395	ABC-type sugar transport system, permease component
IMCC25003_RS00930	COG1175	transmembrane transport
IMCC25003_RS00935	COG1653	transport
IMCC25003_RS00940	COG1609	Transcriptional regulator
IMCC25003_RS00945	COG0586	Pfam SNARE associated Golgi protein
IMCC25003_RS00950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IMCC25003_RS00965	COG0789	Transcriptional regulator
IMCC25003_RS00970	COG0484	heat shock protein binding
IMCC25003_RS00975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IMCC25003_RS00980	COG0443	Heat shock 70 kDa protein
IMCC25003_RS00985	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IMCC25003_RS00990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IMCC25003_RS00995	COG0592	DNA-directed DNA polymerase activity
IMCC25003_RS01000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IMCC25003_RS01005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IMCC25003_RS01010	COG0594	ribonuclease P activity
IMCC25003_RS01015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IMCC25003_RS01020	COG0706	membrane insertase activity
IMCC25003_RS01030	COG0357	Ribosomal RNA small subunit methyltransferase G
IMCC25003_RS01035	COG1192	Involved in chromosome partitioning
IMCC25003_RS01045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMCC25003_RS01050	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMCC25003_RS01055	COG3118	belongs to the thioredoxin family
IMCC25003_RS01060	COG0492	ferredoxin-NADP+ reductase activity
IMCC25003_RS01080	COG0617	tRNA 3'-terminal CCA addition
IMCC25003_RS01095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IMCC25003_RS01105	COG0360	Binds together with S18 to 16S ribosomal RNA
IMCC25003_RS01110	COG0629	single-stranded DNA binding
IMCC25003_RS01115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IMCC25003_RS01120	COG0359	binds to the 23S rRNA
IMCC25003_RS01125	COG0598	Magnesium transport protein CorA
IMCC25003_RS01130	COG0305	Participates in initiation and elongation during chromosome replication
IMCC25003_RS01140	COG1960	acyl-CoA dehydrogenase activity
IMCC25003_RS01145	COG0717	Belongs to the dCTP deaminase family
IMCC25003_RS01150	COG1704	LemA family
IMCC25003_RS01155	COG0501	Belongs to the peptidase M48B family
IMCC25003_RS01160	COG2205	protein histidine kinase activity
IMCC25003_RS01165	COG0745	RESPONSE REGULATOR receiver
IMCC25003_RS01170	COG0187	DNA topoisomerase II activity
IMCC25003_RS01175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IMCC25003_RS01200	COG0457	Tetratricopeptide repeat
IMCC25003_RS01200	COG0705	Rhomboid family
IMCC25003_RS01205	COG2181	nitrate reductase activity
IMCC25003_RS01205	COG0247	lactate metabolic process
IMCC25003_RS01225	COG0515	serine threonine protein kinase
IMCC25003_RS01245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IMCC25003_RS01250	COG0561	phosphatase activity
IMCC25003_RS01265	COG1053	succinate dehydrogenase
IMCC25003_RS01270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IMCC25003_RS01275	COG1950	PFAM Membrane protein of
IMCC25003_RS01280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IMCC25003_RS01290	COG0006	proline dipeptidase activity
IMCC25003_RS01295	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IMCC25003_RS01295	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IMCC25003_RS01295	COG0506	proline dehydrogenase activity
IMCC25003_RS01310	COG2376	Dihydroxyacetone kinase
IMCC25003_RS01320	COG1129	ABC transporter
IMCC25003_RS01325	COG1172	Belongs to the binding-protein-dependent transport system permease family
IMCC25003_RS01330	COG1172	Belongs to the binding-protein-dependent transport system permease family
IMCC25003_RS01335	COG1363	Peptidase, m42
IMCC25003_RS01345	COG1063	alcohol dehydrogenase
IMCC25003_RS01355	COG2084	Dehydrogenase
IMCC25003_RS01360	COG0434	BtpA family
IMCC25003_RS01365	COG1349	DNA-binding transcription factor activity
IMCC25003_RS01385	COG0737	Belongs to the 5'-nucleotidase family
IMCC25003_RS01385	COG1525	nuclease
IMCC25003_RS01385	COG4085	toxin activity
IMCC25003_RS01405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IMCC25003_RS01430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IMCC25003_RS01435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IMCC25003_RS01440	COG0586	Pfam SNARE associated Golgi protein
IMCC25003_RS01450	COG3483	tryptophan 2,3-dioxygenase activity
IMCC25003_RS01460	COG0488	(ABC) transporter
IMCC25003_RS01480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IMCC25003_RS01495	COG0531	amino acid
IMCC25003_RS01540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IMCC25003_RS01555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IMCC25003_RS01560	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IMCC25003_RS01570	COG1610	YqeY-like protein
IMCC25003_RS01600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IMCC25003_RS01605	COG0191	fructose-bisphosphate aldolase activity
IMCC25003_RS01610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IMCC25003_RS01615	COG0151	Belongs to the GarS family
IMCC25003_RS01620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IMCC25003_RS01625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IMCC25003_RS01630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IMCC25003_RS01635	COG0047	phosphoribosylformylglycinamidine synthase activity
IMCC25003_RS01640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IMCC25003_RS01680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IMCC25003_RS01715	COG0438	transferase activity, transferring glycosyl groups
IMCC25003_RS01720	COG0009	L-threonylcarbamoyladenylate synthase
IMCC25003_RS01735	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IMCC25003_RS01760	COG2027	D-alanyl-D-alanine carboxypeptidase
IMCC25003_RS01770	COG0109	protoheme IX farnesyltransferase activity
IMCC25003_RS01795	COG0037	tRNA processing
IMCC25003_RS01810	COG0302	gtp cyclohydrolase
IMCC25003_RS01815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IMCC25003_RS01825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IMCC25003_RS01830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IMCC25003_RS01835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IMCC25003_RS01845	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IMCC25003_RS01850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IMCC25003_RS01855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IMCC25003_RS01865	COG1194	a g-specific adenine glycosylase
IMCC25003_RS01870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IMCC25003_RS01880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IMCC25003_RS01900	COG1061	Type III restriction enzyme res subunit
IMCC25003_RS01920	COG0406	alpha-ribazole phosphatase activity
IMCC25003_RS01925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMCC25003_RS01930	COG0785	Cytochrome C biogenesis protein
IMCC25003_RS01935	COG1333	cytochrome c biogenesis protein
IMCC25003_RS01940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IMCC25003_RS01965	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IMCC25003_RS01970	COG4948	Mandelate Racemase Muconate Lactonizing
IMCC25003_RS01975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IMCC25003_RS01980	COG1169	isochorismate synthase
IMCC25003_RS01985	COG1268	BioY protein
IMCC25003_RS01990	COG2226	methyltransferase
IMCC25003_RS02005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IMCC25003_RS02010	COG0649	NAD binding
IMCC25003_RS02020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IMCC25003_RS02025	COG1034	ATP synthesis coupled electron transport
IMCC25003_RS02030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IMCC25003_RS02035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IMCC25003_RS02040	COG0839	Belongs to the complex I subunit 6 family
IMCC25003_RS02065	COG0142	geranyltranstransferase activity
IMCC25003_RS02075	COG1666	GTP binding
IMCC25003_RS02085	COG1172	Belongs to the binding-protein-dependent transport system permease family
IMCC25003_RS02125	COG4948	Mandelate Racemase Muconate Lactonizing
IMCC25003_RS02135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMCC25003_RS02150	COG0395	ABC-type sugar transport system, permease component
IMCC25003_RS02155	COG1832	CoA-binding protein
IMCC25003_RS02180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IMCC25003_RS02185	COG2030	dehydratase
IMCC25003_RS02195	COG0215	cysteine-tRNA ligase activity
IMCC25003_RS02200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IMCC25003_RS02205	COG0436	Aminotransferase
IMCC25003_RS02215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IMCC25003_RS02225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IMCC25003_RS02230	COG0081	regulation of translation
IMCC25003_RS02235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IMCC25003_RS02240	COG0222	ribosome binding
IMCC25003_RS02245	COG0085	RNA polymerase activity
IMCC25003_RS02250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IMCC25003_RS02260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IMCC25003_RS02265	COG0049	tRNA binding
IMCC25003_RS02270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IMCC25003_RS02275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IMCC25003_RS02280	COG0051	transcription antitermination factor activity, RNA binding
IMCC25003_RS02285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IMCC25003_RS02290	COG0088	Forms part of the polypeptide exit tunnel
IMCC25003_RS02295	COG0089	rRNA binding
IMCC25003_RS02305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IMCC25003_RS02310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IMCC25003_RS02315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IMCC25003_RS02320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IMCC25003_RS02325	COG0255	Belongs to the universal ribosomal protein uL29 family
IMCC25003_RS02330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IMCC25003_RS02335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IMCC25003_RS02340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IMCC25003_RS02345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IMCC25003_RS02350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IMCC25003_RS02355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IMCC25003_RS02360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IMCC25003_RS02370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IMCC25003_RS02375	COG1841	ribosomal large subunit assembly
IMCC25003_RS02380	COG0200	Binds to the 23S rRNA
IMCC25003_RS02390	COG0563	adenylate kinase activity
IMCC25003_RS02395	COG0024	Methionine aminopeptidase
IMCC25003_RS02420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IMCC25003_RS02425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IMCC25003_RS02430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IMCC25003_RS02435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IMCC25003_RS02440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IMCC25003_RS02445	COG0202	RNA polymerase activity
IMCC25003_RS02450	COG0203	ribosomal protein L17
IMCC25003_RS02455	COG0101	tRNA pseudouridine synthase activity
IMCC25003_RS02460	COG0488	(ABC) transporter
IMCC25003_RS02465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IMCC25003_RS02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IMCC25003_RS02475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IMCC25003_RS02480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IMCC25003_RS02490	COG0736	holo-[acyl-carrier-protein] synthase activity
IMCC25003_RS02495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IMCC25003_RS02510	COG0559	Belongs to the binding-protein-dependent transport system permease family
IMCC25003_RS02515	COG0559	Belongs to the binding-protein-dependent transport system permease family
IMCC25003_RS02530	COG0802	atpase or kinase
IMCC25003_RS02535	COG1214	PFAM Peptidase M22, glycoprotease
IMCC25003_RS02535	COG0456	acetyltransferase
IMCC25003_RS02540	COG0456	acetyltransferase
IMCC25003_RS02540	COG1214	PFAM Peptidase M22, glycoprotease
IMCC25003_RS02545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IMCC25003_RS02550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IMCC25003_RS02575	COG0516	GMP reductase activity
IMCC25003_RS02580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IMCC25003_RS02580	COG0519	Catalyzes the synthesis of GMP from XMP
IMCC25003_RS02585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IMCC25003_RS02590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IMCC25003_RS02600	COG0045	succinate-CoA ligase (ADP-forming) activity
IMCC25003_RS02625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IMCC25003_RS02635	COG0039	L-malate dehydrogenase activity
IMCC25003_RS02640	COG0538	isocitrate dehydrogenase activity
IMCC25003_RS02650	COG3842	ATPase activity
IMCC25003_RS02655	COG1253	flavin adenine dinucleotide binding
IMCC25003_RS02660	COG0180	Tryptophanyl-tRNA synthetase
IMCC25003_RS02665	COG1744	ABC transporter substrate-binding protein PnrA-like
IMCC25003_RS02670	COG1744	ABC transporter substrate-binding protein PnrA-like
IMCC25003_RS02675	COG3845	ABC transporter
IMCC25003_RS02680	COG4603	Belongs to the binding-protein-dependent transport system permease family
IMCC25003_RS02685	COG1079	Belongs to the binding-protein-dependent transport system permease family
IMCC25003_RS02700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IMCC25003_RS02705	COG1012	belongs to the aldehyde dehydrogenase family
IMCC25003_RS02710	COG1012	belongs to the aldehyde dehydrogenase family
IMCC25003_RS02720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IMCC25003_RS02730	COG4770	biotin carboxylase activity
IMCC25003_RS02735	COG0424	maF-like protein
IMCC25003_RS02745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IMCC25003_RS02760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IMCC25003_RS02765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IMCC25003_RS02770	COG1316	TRANSCRIPTIONal
IMCC25003_RS02795	COG2171	N-acyltransferase activity
IMCC25003_RS02800	COG1611	Belongs to the LOG family
IMCC25003_RS02820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IMCC25003_RS02830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMCC25003_RS02835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IMCC25003_RS02840	COG0489	protein tyrosine kinase activity
IMCC25003_RS02840	COG2151	metal-sulfur cluster biosynthetic enzyme
IMCC25003_RS02850	COG2239	Acts as a magnesium transporter
IMCC25003_RS02865	COG2095	MarC family integral membrane protein
IMCC25003_RS02870	COG0513	Belongs to the DEAD box helicase family
IMCC25003_RS02890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IMCC25003_RS02900	COG0215	cysteine-tRNA ligase activity
IMCC25003_RS02905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IMCC25003_RS02940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IMCC25003_RS02945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IMCC25003_RS02950	COG0745	RESPONSE REGULATOR receiver
IMCC25003_RS02955	COG5000	phosphorelay sensor kinase activity
IMCC25003_RS02955	COG5002	protein histidine kinase activity
IMCC25003_RS02960	COG1040	competence protein
IMCC25003_RS02965	COG0653	protein targeting
IMCC25003_RS02980	COG2894	cell division
IMCC25003_RS03005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMCC25003_RS03040	COG0745	RESPONSE REGULATOR receiver
IMCC25003_RS03045	COG5002	protein histidine kinase activity
IMCC25003_RS03055	COG0137	argininosuccinate synthase activity
IMCC25003_RS03060	COG0545	Peptidyl-prolyl cis-trans isomerase
IMCC25003_RS03065	COG0366	Alpha amylase catalytic
IMCC25003_RS03090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IMCC25003_RS03105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IMCC25003_RS03130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IMCC25003_RS03155	COG2814	Major facilitator Superfamily
IMCC25003_RS03165	COG0668	transmembrane transport
IMCC25003_RS03185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IMCC25003_RS03190	COG0698	ribose 5-phosphate isomerase
IMCC25003_RS03215	COG0544	peptidyl-prolyl cis-trans isomerase activity
IMCC25003_RS03220	COG0740	serine-type endopeptidase activity
IMCC25003_RS03225	COG0740	serine-type endopeptidase activity
IMCC25003_RS03235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IMCC25003_RS03240	COG0525	valine-tRNA ligase activity
IMCC25003_RS03245	COG0285	dihydrofolate synthase activity
IMCC25003_RS03255	COG0105	UTP biosynthetic process
IMCC25003_RS03260	COG1077	Cell shape determining protein MreB Mrl
IMCC25003_RS03280	COG0772	Belongs to the SEDS family
IMCC25003_RS03285	COG1530	ribonuclease E activity
IMCC25003_RS03290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IMCC25003_RS03295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IMCC25003_RS03300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IMCC25003_RS03305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IMCC25003_RS03310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IMCC25003_RS03315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IMCC25003_RS03320	COG0154	amidase activity
IMCC25003_RS03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IMCC25003_RS03335	COG0129	dihydroxy-acid dehydratase activity
IMCC25003_RS03345	COG0440	acetolactate synthase activity
IMCC25003_RS03350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IMCC25003_RS03360	COG0473	3-isopropylmalate dehydrogenase activity
IMCC25003_RS03365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IMCC25003_RS03370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IMCC25003_RS03390	COG0052	Belongs to the universal ribosomal protein uS2 family
IMCC25003_RS03395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IMCC25003_RS03400	COG0528	UMP kinase activity
IMCC25003_RS03405	COG0233	cytoplasmic translational termination
IMCC25003_RS03415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IMCC25003_RS03425	COG1012	belongs to the aldehyde dehydrogenase family
IMCC25003_RS03435	COG3842	ATPase activity
IMCC25003_RS03440	COG1176	ABC-type spermidine putrescine transport system, permease component I
IMCC25003_RS03455	COG0750	zinc metalloprotease
IMCC25003_RS03460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IMCC25003_RS03465	COG0442	prolyl-tRNA aminoacylation
IMCC25003_RS03470	COG0730	response to heat
IMCC25003_RS03475	COG0779	Required for maturation of 30S ribosomal subunits
IMCC25003_RS03485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IMCC25003_RS03485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IMCC25003_RS03490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IMCC25003_RS03495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IMCC25003_RS03510	COG1185	polyribonucleotide nucleotidyltransferase activity
IMCC25003_RS03515	COG0612	Peptidase, M16
IMCC25003_RS03520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IMCC25003_RS03540	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IMCC25003_RS03545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IMCC25003_RS03550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IMCC25003_RS03555	COG1674	ftsk spoiiie
IMCC25003_RS03565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IMCC25003_RS03575	COG1058	Belongs to the CinA family
IMCC25003_RS03575	COG1546	Belongs to the CinA family
IMCC25003_RS03580	COG1396	sequence-specific DNA binding
IMCC25003_RS03610	COG2137	regulation of response to DNA damage stimulus
IMCC25003_RS03620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IMCC25003_RS03625	COG0066	3-isopropylmalate dehydratase activity
IMCC25003_RS03630	COG0776	regulation of translation
IMCC25003_RS03640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IMCC25003_RS03645	COG1181	Belongs to the D-alanine--D-alanine ligase family
IMCC25003_RS03660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IMCC25003_RS03670	COG0742	ribosomal rna small subunit methyltransferase
IMCC25003_RS03675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IMCC25003_RS03690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IMCC25003_RS03695	COG0571	ribonuclease III activity
IMCC25003_RS03705	COG0552	protein localization to endoplasmic reticulum
IMCC25003_RS03720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IMCC25003_RS03725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IMCC25003_RS03730	COG0228	four-way junction DNA binding
IMCC25003_RS03735	COG1837	Belongs to the UPF0109 family
IMCC25003_RS03740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IMCC25003_RS03745	COG0336	Belongs to the RNA methyltransferase TrmD family
IMCC25003_RS03755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IMCC25003_RS03760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IMCC25003_RS03765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IMCC25003_RS03770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IMCC25003_RS03790	COG0756	dUTP diphosphatase activity
IMCC25003_RS03805	COG0569	domain protein
IMCC25003_RS03810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IMCC25003_RS03815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IMCC25003_RS03820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IMCC25003_RS03825	COG1024	Enoyl-CoA hydratase
IMCC25003_RS03825	COG1250	3-hydroxyacyl-CoA dehydrogenase
IMCC25003_RS03830	COG0183	Belongs to the thiolase family
IMCC25003_RS03835	COG0672	)-iron permease
IMCC25003_RS03860	COG0791	NLP P60 protein
IMCC25003_RS03865	COG0438	transferase activity, transferring glycosyl groups
IMCC25003_RS03890	COG1940	carbohydrate kinase activity
IMCC25003_RS03910	COG1280	lysine exporter protein (LysE YggA)
IMCC25003_RS03920	COG1260	myo-inositol-1-phosphate synthase
IMCC25003_RS03925	COG1024	Enoyl-CoA hydratase
IMCC25003_RS03930	COG0300	oxidoreductase activity
IMCC25003_RS03935	COG1126	abc transporter atp-binding protein
IMCC25003_RS03940	COG0765	amino acid transport
IMCC25003_RS03945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IMCC25003_RS03955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IMCC25003_RS03960	COG0174	glutamine synthetase
IMCC25003_RS03980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IMCC25003_RS03985	COG0321	lipoyl(octanoyl) transferase activity
IMCC25003_RS03990	COG2409	Drug exporters of the RND superfamily
IMCC25003_RS03995	COG0673	inositol 2-dehydrogenase activity
IMCC25003_RS04000	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IMCC25003_RS04005	COG1090	epimerase
IMCC25003_RS04010	COG0508	dehydrogenase complex catalyzes the overall conversion of
IMCC25003_RS04015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IMCC25003_RS04020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IMCC25003_RS04025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IMCC25003_RS04035	COG3845	ABC transporter
IMCC25003_RS04040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IMCC25003_RS04050	COG0667	Aldo Keto reductase
IMCC25003_RS04060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IMCC25003_RS04070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IMCC25003_RS04080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IMCC25003_RS04085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IMCC25003_RS04100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IMCC25003_RS04105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IMCC25003_RS04110	COG0723	plastoquinol--plastocyanin reductase activity
IMCC25003_RS04120	COG1845	cytochrome c oxidase, subunit III
IMCC25003_RS04130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IMCC25003_RS04145	COG2986	histidine ammonia-lyase
IMCC25003_RS04150	COG1228	amidohydrolase
IMCC25003_RS04155	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IMCC25003_RS04190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IMCC25003_RS04195	COG3938	Belongs to the proline racemase family
IMCC25003_RS04205	COG0697	spore germination
IMCC25003_RS04235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IMCC25003_RS04245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IMCC25003_RS04260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IMCC25003_RS04265	COG1560	Kdo2-lipid A biosynthetic process
IMCC25003_RS04270	COG0438	transferase activity, transferring glycosyl groups
IMCC25003_RS04290	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IMCC25003_RS04295	COG0217	transcriptional regulatory protein
IMCC25003_RS04300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IMCC25003_RS04305	COG0632	four-way junction helicase activity
IMCC25003_RS04310	COG2255	four-way junction helicase activity
IMCC25003_RS04315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IMCC25003_RS04320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IMCC25003_RS04325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IMCC25003_RS04330	COG1196	nuclear chromosome segregation
IMCC25003_RS04335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMCC25003_RS04340	COG0124	histidyl-tRNA synthetase
IMCC25003_RS04345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IMCC25003_RS04355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IMCC25003_RS04360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IMCC25003_RS04370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IMCC25003_RS04380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IMCC25003_RS04385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IMCC25003_RS04390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IMCC25003_RS04395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IMCC25003_RS04400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IMCC25003_RS04405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IMCC25003_RS04415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IMCC25003_RS04420	COG0540	Belongs to the ATCase OTCase family
IMCC25003_RS04425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IMCC25003_RS04430	COG0505	Belongs to the CarA family
IMCC25003_RS04435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IMCC25003_RS04440	COG0543	2 iron, 2 sulfur cluster binding
IMCC25003_RS04445	COG0167	dihydroorotate dehydrogenase activity
IMCC25003_RS04450	COG0284	orotidine-5'-phosphate decarboxylase activity
IMCC25003_RS04455	COG0194	GDP metabolic process
IMCC25003_RS04460	COG1758	RNA polymerase activity
IMCC25003_RS04470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IMCC25003_RS04480	COG0242	peptide deformylase activity
IMCC25003_RS04485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IMCC25003_RS04495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IMCC25003_RS04500	COG0140	phosphoribosyl-ATP diphosphatase activity
IMCC25003_RS04505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IMCC25003_RS04510	COG3830	Belongs to the UPF0237 family
IMCC25003_RS04510	COG0560	Phosphoserine phosphatase
IMCC25003_RS04515	COG1119	ATPase activity
IMCC25003_RS04520	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IMCC25003_RS04525	COG2252	PERMEase
IMCC25003_RS04530	COG2364	Membrane
IMCC25003_RS04535	COG1811	Na channel or pump
IMCC25003_RS04540	COG1064	alcohol dehydrogenase
IMCC25003_RS04545	COG1435	thymidine kinase activity
IMCC25003_RS04550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IMCC25003_RS04550	COG2755	lipolytic protein G-D-S-L family
IMCC25003_RS04555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IMCC25003_RS04565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IMCC25003_RS04570	COG0667	Aldo Keto reductase
IMCC25003_RS04590	COG0215	cysteine-tRNA ligase activity
IMCC25003_RS04600	COG0646	methionine synthase
IMCC25003_RS04600	COG1410	methionine synthase
IMCC25003_RS04615	COG2378	regulation of single-species biofilm formation
IMCC25003_RS04625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IMCC25003_RS04630	COG0805	protein transport
IMCC25003_RS04645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IMCC25003_RS04650	COG0463	Glycosyl transferase, family 2
IMCC25003_RS04655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IMCC25003_RS04655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IMCC25003_RS04685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IMCC25003_RS04690	COG1160	GTP binding
IMCC25003_RS04710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IMCC25003_RS04715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IMCC25003_RS04735	COG0504	CTP synthase activity
IMCC25003_RS04740	COG0497	DNA recombination
IMCC25003_RS04745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IMCC25003_RS04785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IMCC25003_RS04790	COG0165	Argininosuccinate lyase
IMCC25003_RS04795	COG1438	arginine binding
IMCC25003_RS04800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IMCC25003_RS04810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IMCC25003_RS04815	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IMCC25003_RS04820	COG0072	phenylalanine-tRNA ligase activity
IMCC25003_RS04820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMCC25003_RS04825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IMCC25003_RS04830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IMCC25003_RS04835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IMCC25003_RS04840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IMCC25003_RS04845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IMCC25003_RS04850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IMCC25003_RS04870	COG1132	(ABC) transporter
IMCC25003_RS04875	COG2151	metal-sulfur cluster biosynthetic enzyme
IMCC25003_RS04880	COG0822	iron-sulfur transferase activity
IMCC25003_RS04885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IMCC25003_RS04890	COG0396	ATPase activity
IMCC25003_RS04895	COG2146	nitrite reductase [NAD(P)H] activity
IMCC25003_RS04900	COG0719	Fe-S assembly protein
IMCC25003_RS04915	COG1612	heme a metabolic process
IMCC25003_RS04920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IMCC25003_RS04925	COG0166	Belongs to the GPI family
IMCC25003_RS04940	COG0149	triose-phosphate isomerase activity
IMCC25003_RS04945	COG0126	phosphoglycerate kinase activity
IMCC25003_RS04950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IMCC25003_RS04955	COG1481	regulation of sporulation
IMCC25003_RS04965	COG1660	Displays ATPase and GTPase activities
IMCC25003_RS04970	COG0322	excinuclease ABC activity
IMCC25003_RS04975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IMCC25003_RS04980	COG0556	nucleotide-excision repair
IMCC25003_RS04985	COG0237	dephospho-CoA kinase activity
IMCC25003_RS04990	COG0539	negative regulation of cytoplasmic translation
IMCC25003_RS05005	COG2050	protein possibly involved in aromatic compounds catabolism
IMCC25003_RS05055	COG0067	glutamate synthase
IMCC25003_RS05055	COG0069	glutamate synthase activity
IMCC25003_RS05055	COG0070	glutamate synthase
IMCC25003_RS05065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IMCC25003_RS05080	COG0159	tryptophan synthase activity
IMCC25003_RS05085	COG0133	tryptophan synthase activity
IMCC25003_RS05090	COG0134	indole-3-glycerol-phosphate synthase activity
IMCC25003_RS05095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IMCC25003_RS05100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IMCC25003_RS05105	COG0107	imidazoleglycerol-phosphate synthase activity
IMCC25003_RS05110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IMCC25003_RS05120	COG0131	Imidazoleglycerol-phosphate dehydratase
IMCC25003_RS05125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IMCC25003_RS05130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IMCC25003_RS05145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IMCC25003_RS05155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IMCC25003_RS05165	COG1799	cell septum assembly
IMCC25003_RS05170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IMCC25003_RS05175	COG1496	oxidoreductase activity
IMCC25003_RS05180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IMCC25003_RS05190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IMCC25003_RS05195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IMCC25003_RS05205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IMCC25003_RS05210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IMCC25003_RS05215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IMCC25003_RS05220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IMCC25003_RS05225	COG0768	penicillin binding
IMCC25003_RS05235	COG0275	rRNA processing
IMCC25003_RS05240	COG2001	Belongs to the MraZ family
IMCC25003_RS05250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IMCC25003_RS05255	COG0587	DNA-directed DNA polymerase activity
IMCC25003_RS05270	COG0730	response to heat
IMCC25003_RS05275	COG2271	Major facilitator Superfamily
IMCC25003_RS05285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IMCC25003_RS05305	COG0463	Glycosyl transferase, family 2
IMCC25003_RS05315	COG1183	phosphatidylcholine synthase activity
IMCC25003_RS05325	COG0142	geranyltranstransferase activity
IMCC25003_RS05345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IMCC25003_RS05345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IMCC25003_RS05350	COG2815	serine threonine protein kinase
IMCC25003_RS05350	COG0515	serine threonine protein kinase
IMCC25003_RS05355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IMCC25003_RS05370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IMCC25003_RS05375	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IMCC25003_RS05380	COG0205	6-phosphofructokinase activity
IMCC25003_RS05385	COG1070	Carbohydrate kinase
IMCC25003_RS05390	COG3046	protein related to deoxyribodipyrimidine photolyase
IMCC25003_RS05395	COG0657	acetylesterase activity
IMCC25003_RS05400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IMCC25003_RS05405	COG0297	glycogen (starch) synthase activity
IMCC25003_RS05415	COG1968	undecaprenyl-diphosphatase activity
IMCC25003_RS05420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IMCC25003_RS05435	COG0792	nuclease activity
IMCC25003_RS05440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IMCC25003_RS05445	COG0681	Belongs to the peptidase S26 family
IMCC25003_RS05450	COG0335	large ribosomal subunit rRNA binding
IMCC25003_RS05470	COG2313	pseudouridylate synthase activity
IMCC25003_RS05475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IMCC25003_RS05480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IMCC25003_RS05490	COG0488	(ABC) transporter
IMCC25003_RS05510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IMCC25003_RS05515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IMCC25003_RS05535	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IMCC25003_RS05540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMCC25003_RS05545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IMCC25003_RS05570	COG0697	spore germination
IMCC25003_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
IMCC25003_RS05585	COG4948	Mandelate Racemase Muconate Lactonizing
IMCC25003_RS05600	COG1174	glycine betaine transport
IMCC25003_RS05610	COG1174	glycine betaine transport
IMCC25003_RS05625	COG3384	dioxygenase
IMCC25003_RS05635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IMCC25003_RS05640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IMCC25003_RS05655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IMCC25003_RS05660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IMCC25003_RS05665	COG1388	LysM domain
IMCC25003_RS05670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IMCC25003_RS05700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IMCC25003_RS05700	COG0519	Catalyzes the synthesis of GMP from XMP
IMCC25003_RS05705	COG1028	Short-chain dehydrogenase reductase Sdr
IMCC25003_RS05710	COG1012	belongs to the aldehyde dehydrogenase family
IMCC25003_RS05895	COG0179	Fumarylacetoacetate (FAA) hydrolase
IMCC25003_RS05900	COG1929	Belongs to the glycerate kinase type-1 family
IMCC25003_RS05905	COG0833	amino acid
IMCC25003_RS05915	COG0277	FAD linked oxidase domain protein
IMCC25003_RS05930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IMCC25003_RS05930	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IMCC25003_RS05935	COG0179	Fumarylacetoacetate (FAA) hydrolase
IMCC25003_RS05960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IMCC25003_RS05965	COG0484	heat shock protein binding
IMCC25003_RS05970	COG1420	regulation of RNA biosynthetic process
IMCC25003_RS05980	COG0481	GTPase activity
IMCC25003_RS05985	COG0268	Binds directly to 16S ribosomal RNA
IMCC25003_RS06005	COG0495	leucyl-tRNA aminoacylation
IMCC25003_RS06015	COG0406	alpha-ribazole phosphatase activity
IMCC25003_RS06020	COG0799	negative regulation of ribosome biogenesis
IMCC25003_RS06025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IMCC25003_RS06030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IMCC25003_RS06035	COG0482	sulfurtransferase activity
IMCC25003_RS06045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IMCC25003_RS06055	COG0438	transferase activity, transferring glycosyl groups
IMCC25003_RS06055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IMCC25003_RS06060	COG0438	transferase activity, transferring glycosyl groups
IMCC25003_RS06080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IMCC25003_RS06085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IMCC25003_RS06115	COG1278	Cold shock
IMCC25003_RS06140	COG0686	Belongs to the AlaDH PNT family
IMCC25003_RS06155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IMCC25003_RS06160	COG0494	nUDIX hydrolase
IMCC25003_RS06160	COG0406	alpha-ribazole phosphatase activity
IMCC25003_RS06180	COG5002	protein histidine kinase activity
IMCC25003_RS06185	COG0745	RESPONSE REGULATOR receiver
IMCC25003_RS06195	COG2197	response regulator
IMCC25003_RS06210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IMCC25003_RS06215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IMCC25003_RS06225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IMCC25003_RS06235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMCC25003_RS06240	COG0723	plastoquinol--plastocyanin reductase activity
IMCC25003_RS06255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IMCC25003_RS06270	COG0423	glycine-tRNA ligase activity
IMCC25003_RS06285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IMCC25003_RS06290	COG1381	Involved in DNA repair and RecF pathway recombination
IMCC25003_RS06295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IMCC25003_RS06315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IMCC25003_RS06315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IMCC25003_RS06320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IMCC25003_RS06340	COG3590	peptidase
IMCC25003_RS06350	COG4608	Belongs to the ABC transporter superfamily
IMCC25003_RS06355	COG0444	Belongs to the ABC transporter superfamily
IMCC25003_RS06365	COG4166	transmembrane transport
IMCC25003_RS06370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IMCC25003_RS06395	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IMCC25003_RS06400	COG0363	glucosamine-6-phosphate deaminase activity
IMCC25003_RS06410	COG2909	trisaccharide binding
IMCC25003_RS06420	COG1982	Orn Lys Arg decarboxylase major
IMCC25003_RS06465	COG3962	Belongs to the TPP enzyme family
IMCC25003_RS06480	COG0673	inositol 2-dehydrogenase activity
IMCC25003_RS06485	COG0673	inositol 2-dehydrogenase activity
IMCC25003_RS06490	COG0697	spore germination
IMCC25003_RS06520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IMCC25003_RS06520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IMCC25003_RS06525	COG2311	Membrane
IMCC25003_RS06545	COG1063	alcohol dehydrogenase
IMCC25003_RS06555	COG0395	ABC-type sugar transport system, permease component
IMCC25003_RS06615	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IMCC25003_RS06620	COG0366	Alpha amylase catalytic
IMCC25003_RS06625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IMCC25003_RS06655	COG1012	belongs to the aldehyde dehydrogenase family
IMCC25003_RS06665	COG1131	(ABC) transporter
IMCC25003_RS06700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IMCC25003_RS06705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IMCC25003_RS06710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IMCC25003_RS06715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IMCC25003_RS06720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IMCC25003_RS06725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IMCC25003_RS06730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IMCC25003_RS06735	COG0356	it plays a direct role in the translocation of protons across the membrane
IMCC25003_RS06755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IMCC25003_RS06765	COG2890	protein-(glutamine-N5) methyltransferase activity
IMCC25003_RS06770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IMCC25003_RS06775	COG0254	rRNA binding
IMCC25003_RS06790	COG0083	homoserine kinase activity
IMCC25003_RS06795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IMCC25003_RS06800	COG0460	homoserine dehydrogenase
IMCC25003_RS06810	COG0018	arginyl-trna synthetase
IMCC25003_RS06815	COG4213	ABC transporter substrate-binding protein
IMCC25003_RS06825	COG4214	carbohydrate transport
IMCC25003_RS06880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IMCC25003_RS06885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IMCC25003_RS06890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IMCC25003_RS06915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IMCC25003_RS06935	COG1054	Belongs to the UPF0176 family
IMCC25003_RS06945	COG1741	Belongs to the pirin family
IMCC25003_RS06970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline