locus-tag	class	description
B1s21122_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1s21122_RS00010	COG0592	DNA-directed DNA polymerase activity
B1s21122_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1s21122_RS00025	COG0187	DNA topoisomerase II activity
B1s21122_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1s21122_RS00065	COG0515	serine threonine protein kinase
B1s21122_RS00080	COG0077	Prephenate dehydratase
B1s21122_RS00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1s21122_RS00105	COG1053	succinate dehydrogenase
B1s21122_RS00120	COG0006	proline dipeptidase activity
B1s21122_RS00130	COG1086	Polysaccharide biosynthesis protein
B1s21122_RS00135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1s21122_RS00150	COG0706	membrane insertase activity
B1s21122_RS00160	COG0357	Ribosomal RNA small subunit methyltransferase G
B1s21122_RS00165	COG1192	Involved in chromosome partitioning
B1s21122_RS00175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1s21122_RS00185	COG3118	belongs to the thioredoxin family
B1s21122_RS00190	COG0492	ferredoxin-NADP+ reductase activity
B1s21122_RS00210	COG0617	tRNA 3'-terminal CCA addition
B1s21122_RS00225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1s21122_RS00235	COG0360	Binds together with S18 to 16S ribosomal RNA
B1s21122_RS00245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1s21122_RS00250	COG0359	binds to the 23S rRNA
B1s21122_RS00255	COG0305	Participates in initiation and elongation during chromosome replication
B1s21122_RS00270	COG1960	acyl-CoA dehydrogenase activity
B1s21122_RS00275	COG0717	Belongs to the dCTP deaminase family
B1s21122_RS00280	COG2205	protein histidine kinase activity
B1s21122_RS00285	COG0745	RESPONSE REGULATOR receiver
B1s21122_RS00290	COG0247	lactate metabolic process
B1s21122_RS00290	COG2181	nitrate reductase activity
B1s21122_RS00295	COG0443	Heat shock 70 kDa protein
B1s21122_RS00300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1s21122_RS00305	COG0484	heat shock protein binding
B1s21122_RS00310	COG0789	Transcriptional regulator
B1s21122_RS00315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1s21122_RS00325	COG0438	transferase activity, transferring glycosyl groups
B1s21122_RS00330	COG0586	Pfam SNARE associated Golgi protein
B1s21122_RS00335	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1s21122_RS00340	COG1754	DNA topoisomerase type I activity
B1s21122_RS00340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1s21122_RS00345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1s21122_RS00350	COG0470	DNA polymerase III
B1s21122_RS00360	COG0513	Belongs to the DEAD box helicase family
B1s21122_RS00375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1s21122_RS00395	COG2027	D-alanyl-D-alanine carboxypeptidase
B1s21122_RS00400	COG0109	protoheme IX farnesyltransferase activity
B1s21122_RS00415	COG0791	NLP P60 protein
B1s21122_RS00420	COG0037	tRNA processing
B1s21122_RS00435	COG0302	gtp cyclohydrolase
B1s21122_RS00440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1s21122_RS00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1s21122_RS00450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1s21122_RS00455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1s21122_RS00460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1s21122_RS00470	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1s21122_RS00475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1s21122_RS00480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1s21122_RS00490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B1s21122_RS00525	COG1061	Type III restriction enzyme res subunit
B1s21122_RS00545	COG0406	alpha-ribazole phosphatase activity
B1s21122_RS00555	COG0785	Cytochrome C biogenesis protein
B1s21122_RS00560	COG1333	cytochrome c biogenesis protein
B1s21122_RS00565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1s21122_RS00590	COG4948	Mandelate Racemase Muconate Lactonizing
B1s21122_RS00595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B1s21122_RS00600	COG1169	isochorismate synthase
B1s21122_RS00605	COG2226	methyltransferase
B1s21122_RS00620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1s21122_RS00625	COG0649	NAD binding
B1s21122_RS00635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B1s21122_RS00640	COG1034	ATP synthesis coupled electron transport
B1s21122_RS00645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1s21122_RS00650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1s21122_RS00655	COG0839	Belongs to the complex I subunit 6 family
B1s21122_RS00680	COG0142	geranyltranstransferase activity
B1s21122_RS00725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1s21122_RS00735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1s21122_RS00740	COG0436	Aminotransferase
B1s21122_RS00755	COG0250	Participates in transcription elongation, termination and antitermination
B1s21122_RS00760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1s21122_RS00765	COG0081	regulation of translation
B1s21122_RS00775	COG0222	ribosome binding
B1s21122_RS00780	COG0085	RNA polymerase activity
B1s21122_RS00785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1s21122_RS00800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1s21122_RS00805	COG0049	tRNA binding
B1s21122_RS00810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1s21122_RS00815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1s21122_RS00820	COG0051	transcription antitermination factor activity, RNA binding
B1s21122_RS00825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1s21122_RS00830	COG0088	Forms part of the polypeptide exit tunnel
B1s21122_RS00835	COG0089	rRNA binding
B1s21122_RS00840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1s21122_RS00850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1s21122_RS00855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1s21122_RS00860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1s21122_RS00865	COG0255	Belongs to the universal ribosomal protein uL29 family
B1s21122_RS00870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1s21122_RS00875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1s21122_RS00880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1s21122_RS00885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1s21122_RS00890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1s21122_RS00895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1s21122_RS00900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1s21122_RS00910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1s21122_RS00915	COG1841	ribosomal large subunit assembly
B1s21122_RS00920	COG0200	Binds to the 23S rRNA
B1s21122_RS00930	COG0563	adenylate kinase activity
B1s21122_RS00935	COG0024	Methionine aminopeptidase
B1s21122_RS00940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1s21122_RS00945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1s21122_RS00950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1s21122_RS00955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1s21122_RS00960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1s21122_RS00970	COG0203	ribosomal protein L17
B1s21122_RS00975	COG0101	tRNA pseudouridine synthase activity
B1s21122_RS00980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1s21122_RS00985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1s21122_RS00990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1s21122_RS00995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1s21122_RS01005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1s21122_RS01040	COG0802	atpase or kinase
B1s21122_RS01045	COG0456	acetyltransferase
B1s21122_RS01045	COG1214	PFAM Peptidase M22, glycoprotease
B1s21122_RS01050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1s21122_RS01060	COG0459	protein refolding
B1s21122_RS01065	COG1940	carbohydrate kinase activity
B1s21122_RS01070	COG0516	GMP reductase activity
B1s21122_RS01075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1s21122_RS01090	COG0045	succinate-CoA ligase (ADP-forming) activity
B1s21122_RS01105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1s21122_RS01115	COG0039	L-malate dehydrogenase activity
B1s21122_RS01120	COG0538	isocitrate dehydrogenase activity
B1s21122_RS01125	COG3842	ATPase activity
B1s21122_RS01130	COG1253	flavin adenine dinucleotide binding
B1s21122_RS01135	COG0180	Tryptophanyl-tRNA synthetase
B1s21122_RS01150	COG3845	ABC transporter
B1s21122_RS01155	COG4603	Belongs to the binding-protein-dependent transport system permease family
B1s21122_RS01160	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1s21122_RS01175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1s21122_RS01180	COG1012	belongs to the aldehyde dehydrogenase family
B1s21122_RS01185	COG1012	belongs to the aldehyde dehydrogenase family
B1s21122_RS01190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B1s21122_RS01195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1s21122_RS01205	COG0424	maF-like protein
B1s21122_RS01210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B1s21122_RS01220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1s21122_RS01225	COG1316	TRANSCRIPTIONal
B1s21122_RS01260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1s21122_RS01270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1s21122_RS01275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1s21122_RS01290	COG2239	Acts as a magnesium transporter
B1s21122_RS01315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1s21122_RS01325	COG0215	cysteine-tRNA ligase activity
B1s21122_RS01345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B1s21122_RS01370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1s21122_RS01375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1s21122_RS01385	COG5002	protein histidine kinase activity
B1s21122_RS01385	COG5000	phosphorelay sensor kinase activity
B1s21122_RS01395	COG0653	protein targeting
B1s21122_RS01425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1s21122_RS01430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1s21122_RS01465	COG0277	FAD linked oxidase domain protein
B1s21122_RS01470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1s21122_RS01480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1s21122_RS01505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1s21122_RS01510	COG2884	Cell division ATP-binding protein ftsE
B1s21122_RS01515	COG2177	Part of the ABC transporter FtsEX involved in
B1s21122_RS01520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1s21122_RS01540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B1s21122_RS01645	COG0456	acetyltransferase
B1s21122_RS01660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1s21122_RS01690	COG1054	Belongs to the UPF0176 family
B1s21122_RS01695	COG2197	response regulator
B1s21122_RS01705	COG0343	queuine tRNA-ribosyltransferase activity
B1s21122_RS01715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1s21122_RS01730	COG0444	Belongs to the ABC transporter superfamily
B1s21122_RS01735	COG4608	Belongs to the ABC transporter superfamily
B1s21122_RS01740	COG3590	peptidase
B1s21122_RS01755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1s21122_RS01760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1s21122_RS01760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1s21122_RS01770	COG1045	serine acetyltransferase
B1s21122_RS01790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1s21122_RS01795	COG1381	Involved in DNA repair and RecF pathway recombination
B1s21122_RS01800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1s21122_RS01810	COG0423	glycine-tRNA ligase activity
B1s21122_RS01830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1s21122_RS01885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1s21122_RS01910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1s21122_RS01920	COG1175	transmembrane transport
B1s21122_RS01925	COG0395	ABC-type sugar transport system, permease component
B1s21122_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
B1s21122_RS01960	COG3254	rhamnose metabolic process
B1s21122_RS01965	COG4948	Mandelate Racemase Muconate Lactonizing
B1s21122_RS01980	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1s21122_RS01990	COG1129	ABC transporter
B1s21122_RS02005	COG2040	homocysteine
B1s21122_RS02020	COG1278	Cold shock
B1s21122_RS02040	COG0438	transferase activity, transferring glycosyl groups
B1s21122_RS02045	COG0438	transferase activity, transferring glycosyl groups
B1s21122_RS02055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B1s21122_RS02065	COG0482	sulfurtransferase activity
B1s21122_RS02070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1s21122_RS02075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1s21122_RS02100	COG0495	leucyl-tRNA aminoacylation
B1s21122_RS02115	COG2135	peptidase activity
B1s21122_RS02125	COG0587	DNA-directed DNA polymerase activity
B1s21122_RS02135	COG3046	protein related to deoxyribodipyrimidine photolyase
B1s21122_RS02175	COG3938	Belongs to the proline racemase family
B1s21122_RS02255	COG0519	Catalyzes the synthesis of GMP from XMP
B1s21122_RS02260	COG2721	sulfolactate sulfo-lyase activity
B1s21122_RS02270	COG2721	sulfolactate sulfo-lyase activity
B1s21122_RS02275	COG1070	Carbohydrate kinase
B1s21122_RS02290	COG1070	Carbohydrate kinase
B1s21122_RS02295	COG1129	ABC transporter
B1s21122_RS02300	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1s21122_RS02315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1s21122_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
B1s21122_RS02325	COG1879	ABC-type sugar transport system periplasmic component
B1s21122_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
B1s21122_RS02345	COG3347	Dehydrogenase
B1s21122_RS02350	COG1070	Carbohydrate kinase
B1s21122_RS02355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1s21122_RS02365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1s21122_RS02370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1s21122_RS02400	COG0686	Belongs to the AlaDH PNT family
B1s21122_RS02410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1s21122_RS02415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1s21122_RS02430	COG0187	DNA topoisomerase II activity
B1s21122_RS02435	COG0488	(ABC) transporter
B1s21122_RS02440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1s21122_RS02455	COG0483	inositol monophosphate 1-phosphatase activity
B1s21122_RS02460	COG0335	large ribosomal subunit rRNA binding
B1s21122_RS02465	COG1837	Belongs to the UPF0109 family
B1s21122_RS02470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1s21122_RS02475	COG0336	Belongs to the RNA methyltransferase TrmD family
B1s21122_RS02495	COG0756	dUTP diphosphatase activity
B1s21122_RS02510	COG0569	domain protein
B1s21122_RS02515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1s21122_RS02520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1s21122_RS02525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1s21122_RS02530	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1s21122_RS02530	COG1024	Enoyl-CoA hydratase
B1s21122_RS02535	COG0183	Belongs to the thiolase family
B1s21122_RS02540	COG0672	)-iron permease
B1s21122_RS02575	COG0438	transferase activity, transferring glycosyl groups
B1s21122_RS02580	COG2197	response regulator
B1s21122_RS02600	COG1940	carbohydrate kinase activity
B1s21122_RS02630	COG1260	myo-inositol-1-phosphate synthase
B1s21122_RS02640	COG1024	Enoyl-CoA hydratase
B1s21122_RS02645	COG0300	oxidoreductase activity
B1s21122_RS02650	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B1s21122_RS02665	COG0174	glutamine synthetase
B1s21122_RS02680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1s21122_RS02685	COG0321	lipoyl(octanoyl) transferase activity
B1s21122_RS02690	COG2409	Drug exporters of the RND superfamily
B1s21122_RS02695	COG0673	inositol 2-dehydrogenase activity
B1s21122_RS02700	COG1231	oxidoreductase activity
B1s21122_RS02705	COG1090	epimerase
B1s21122_RS02710	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1s21122_RS02715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1s21122_RS02720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1s21122_RS02725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1s21122_RS02735	COG0667	Aldo Keto reductase
B1s21122_RS02745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1s21122_RS02755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1s21122_RS02765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1s21122_RS02770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1s21122_RS02785	COG1012	belongs to the aldehyde dehydrogenase family
B1s21122_RS02790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1s21122_RS02795	COG0723	plastoquinol--plastocyanin reductase activity
B1s21122_RS02800	COG2010	Cytochrome c
B1s21122_RS02805	COG1845	cytochrome c oxidase, subunit III
B1s21122_RS02815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1s21122_RS02825	COG2095	MarC family integral membrane protein
B1s21122_RS02835	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B1s21122_RS02840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1s21122_RS02850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1s21122_RS02850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1s21122_RS02855	COG1960	acyl-CoA dehydrogenase activity
B1s21122_RS02865	COG1012	belongs to the aldehyde dehydrogenase family
B1s21122_RS02870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B1s21122_RS02885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1s21122_RS02890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1s21122_RS02910	COG3588	fructose-bisphosphate aldolase
B1s21122_RS02950	COG0512	Glutamine amidotransferase of anthranilate synthase
B1s21122_RS02950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1s21122_RS02955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1s21122_RS02965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1s21122_RS02985	COG1560	Kdo2-lipid A biosynthetic process
B1s21122_RS03005	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B1s21122_RS03010	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B1s21122_RS03015	COG0217	transcriptional regulatory protein
B1s21122_RS03020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1s21122_RS03025	COG0632	four-way junction helicase activity
B1s21122_RS03030	COG2255	four-way junction helicase activity
B1s21122_RS03035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1s21122_RS03040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1s21122_RS03045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1s21122_RS03050	COG1196	nuclear chromosome segregation
B1s21122_RS03055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1s21122_RS03060	COG0124	histidyl-tRNA synthetase
B1s21122_RS03065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1s21122_RS03075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1s21122_RS03080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1s21122_RS03085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1s21122_RS03100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1s21122_RS03105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1s21122_RS03110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1s21122_RS03115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1s21122_RS03120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1s21122_RS03125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1s21122_RS03135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1s21122_RS03140	COG0540	Belongs to the ATCase OTCase family
B1s21122_RS03145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1s21122_RS03150	COG0505	Belongs to the CarA family
B1s21122_RS03155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1s21122_RS03165	COG0167	dihydroorotate dehydrogenase activity
B1s21122_RS03170	COG0284	orotidine-5'-phosphate decarboxylase activity
B1s21122_RS03175	COG0194	GDP metabolic process
B1s21122_RS03180	COG1758	RNA polymerase activity
B1s21122_RS03190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1s21122_RS03200	COG0242	peptide deformylase activity
B1s21122_RS03205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1s21122_RS03215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1s21122_RS03220	COG0560	Phosphoserine phosphatase
B1s21122_RS03220	COG3830	Belongs to the UPF0237 family
B1s21122_RS03225	COG1119	ATPase activity
B1s21122_RS03230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1s21122_RS03235	COG2252	PERMEase
B1s21122_RS03240	COG2364	Membrane
B1s21122_RS03245	COG1968	undecaprenyl-diphosphatase activity
B1s21122_RS03255	COG1064	alcohol dehydrogenase
B1s21122_RS03260	COG1435	thymidine kinase activity
B1s21122_RS03265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1s21122_RS03275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1s21122_RS03280	COG0667	Aldo Keto reductase
B1s21122_RS03285	COG0406	alpha-ribazole phosphatase activity
B1s21122_RS03300	COG0215	cysteine-tRNA ligase activity
B1s21122_RS03305	COG1410	methionine synthase
B1s21122_RS03305	COG0646	methionine synthase
B1s21122_RS03310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1s21122_RS03320	COG0545	Peptidyl-prolyl cis-trans isomerase
B1s21122_RS03335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1s21122_RS03340	COG0805	protein transport
B1s21122_RS03345	COG1597	lipid kinase activity
B1s21122_RS03355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1s21122_RS03365	COG1216	Glycosyl transferase, family 2
B1s21122_RS03370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1s21122_RS03370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1s21122_RS03395	COG0509	glycine decarboxylation via glycine cleavage system
B1s21122_RS03405	COG1160	GTP binding
B1s21122_RS03420	COG1187	pseudouridine synthase activity
B1s21122_RS03425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1s21122_RS03430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1s21122_RS03450	COG0504	CTP synthase activity
B1s21122_RS03455	COG0497	DNA recombination
B1s21122_RS03460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1s21122_RS03485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1s21122_RS03490	COG0165	Argininosuccinate lyase
B1s21122_RS03500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1s21122_RS03505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1s21122_RS03510	COG0072	phenylalanine-tRNA ligase activity
B1s21122_RS03510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1s21122_RS03520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1s21122_RS03525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1s21122_RS03530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1s21122_RS03535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1s21122_RS03540	COG2233	PERMEase
B1s21122_RS03550	COG1132	(ABC) transporter
B1s21122_RS03555	COG2151	metal-sulfur cluster biosynthetic enzyme
B1s21122_RS03560	COG0822	iron-sulfur transferase activity
B1s21122_RS03570	COG0396	ATPase activity
B1s21122_RS03575	COG2146	nitrite reductase [NAD(P)H] activity
B1s21122_RS03580	COG0719	Fe-S assembly protein
B1s21122_RS03605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1s21122_RS03610	COG0166	Belongs to the GPI family
B1s21122_RS03625	COG0149	triose-phosphate isomerase activity
B1s21122_RS03630	COG0126	phosphoglycerate kinase activity
B1s21122_RS03635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1s21122_RS03640	COG1481	regulation of sporulation
B1s21122_RS03650	COG1660	Displays ATPase and GTPase activities
B1s21122_RS03655	COG0322	excinuclease ABC activity
B1s21122_RS03660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1s21122_RS03665	COG0556	nucleotide-excision repair
B1s21122_RS03670	COG0237	dephospho-CoA kinase activity
B1s21122_RS03670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B1s21122_RS03675	COG0539	negative regulation of cytoplasmic translation
B1s21122_RS03690	COG2050	protein possibly involved in aromatic compounds catabolism
B1s21122_RS03705	COG0469	pyruvate kinase activity
B1s21122_RS03715	COG0067	glutamate synthase
B1s21122_RS03715	COG0069	glutamate synthase activity
B1s21122_RS03715	COG0070	glutamate synthase
B1s21122_RS03725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1s21122_RS03740	COG0159	tryptophan synthase activity
B1s21122_RS03745	COG0133	tryptophan synthase activity
B1s21122_RS03750	COG0134	indole-3-glycerol-phosphate synthase activity
B1s21122_RS03755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1s21122_RS03760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1s21122_RS03775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1s21122_RS03780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B1s21122_RS03785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1s21122_RS03795	COG1799	cell septum assembly
B1s21122_RS03800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B1s21122_RS03805	COG1496	oxidoreductase activity
B1s21122_RS03810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1s21122_RS03820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1s21122_RS03825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1s21122_RS03835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1s21122_RS03840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1s21122_RS03845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1s21122_RS03850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1s21122_RS03855	COG0768	penicillin binding
B1s21122_RS03865	COG0275	rRNA processing
B1s21122_RS03870	COG2001	Belongs to the MraZ family
B1s21122_RS03880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1s21122_RS03890	COG0730	response to heat
B1s21122_RS03900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1s21122_RS03905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1s21122_RS03910	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1s21122_RS03910	COG0596	Alpha beta hydrolase
B1s21122_RS03925	COG1216	Glycosyl transferase, family 2
B1s21122_RS03935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1s21122_RS03945	COG0142	geranyltranstransferase activity
B1s21122_RS03970	COG3201	nicotinamide mononucleotide transporter
B1s21122_RS03980	COG0515	serine threonine protein kinase
B1s21122_RS03980	COG2815	serine threonine protein kinase
B1s21122_RS03985	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1s21122_RS04005	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B1s21122_RS04010	COG0205	6-phosphofructokinase activity
B1s21122_RS04020	COG0697	spore germination
B1s21122_RS04035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1s21122_RS04040	COG0681	Belongs to the peptidase S26 family
B1s21122_RS04045	COG0228	four-way junction DNA binding
B1s21122_RS04070	COG1196	nuclear chromosome segregation
B1s21122_RS04075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1s21122_RS04080	COG0571	ribonuclease III activity
B1s21122_RS04085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1s21122_RS04100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1s21122_RS04105	COG0742	ribosomal rna small subunit methyltransferase
B1s21122_RS04115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1s21122_RS04120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B1s21122_RS04140	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1s21122_RS04145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1s21122_RS04160	COG0066	3-isopropylmalate dehydratase activity
B1s21122_RS04165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1s21122_RS04170	COG1414	Transcriptional regulator
B1s21122_RS04185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B1s21122_RS04185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1s21122_RS04190	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1s21122_RS04200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1s21122_RS04210	COG0537	adenosine 5'-monophosphoramidase activity
B1s21122_RS04220	COG0484	heat shock protein binding
B1s21122_RS04225	COG1420	regulation of RNA biosynthetic process
B1s21122_RS04235	COG0481	GTPase activity
B1s21122_RS04240	COG0268	Binds directly to 16S ribosomal RNA
B1s21122_RS04250	COG2333	competence protein COMEC
B1s21122_RS04250	COG0658	competence protein
B1s21122_RS04255	COG1596	polysaccharide export
B1s21122_RS04255	COG1555	photosystem II stabilization
B1s21122_RS04285	COG3938	Belongs to the proline racemase family
B1s21122_RS04290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1s21122_RS04295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1s21122_RS04300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1s21122_RS04305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1s21122_RS04315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1s21122_RS04330	COG1396	sequence-specific DNA binding
B1s21122_RS04335	COG1058	Belongs to the CinA family
B1s21122_RS04335	COG1546	Belongs to the CinA family
B1s21122_RS04345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1s21122_RS04355	COG1674	ftsk spoiiie
B1s21122_RS04365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1s21122_RS04370	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B1s21122_RS04390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1s21122_RS04395	COG0612	Peptidase, M16
B1s21122_RS04400	COG1185	polyribonucleotide nucleotidyltransferase activity
B1s21122_RS04405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1s21122_RS04420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1s21122_RS04425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1s21122_RS04425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1s21122_RS04430	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B1s21122_RS04435	COG0195	Participates in both transcription termination and antitermination
B1s21122_RS04440	COG0779	Required for maturation of 30S ribosomal subunits
B1s21122_RS04450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1s21122_RS04455	COG0750	zinc metalloprotease
B1s21122_RS04465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1s21122_RS04470	COG0010	Belongs to the arginase family
B1s21122_RS04485	COG1177	transmembrane transport
B1s21122_RS04490	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1s21122_RS04495	COG3842	ATPase activity
B1s21122_RS04505	COG1012	belongs to the aldehyde dehydrogenase family
B1s21122_RS04510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1s21122_RS04515	COG0575	Belongs to the CDS family
B1s21122_RS04520	COG0233	cytoplasmic translational termination
B1s21122_RS04525	COG0528	UMP kinase activity
B1s21122_RS04530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1s21122_RS04535	COG0052	Belongs to the universal ribosomal protein uS2 family
B1s21122_RS04545	COG4974	Belongs to the 'phage' integrase family
B1s21122_RS04550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1s21122_RS04555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1s21122_RS04560	COG0473	3-isopropylmalate dehydrogenase activity
B1s21122_RS04565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1s21122_RS04570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1s21122_RS04575	COG0440	acetolactate synthase activity
B1s21122_RS04585	COG0129	dihydroxy-acid dehydratase activity
B1s21122_RS04590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1s21122_RS04595	COG0154	amidase activity
B1s21122_RS04600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1s21122_RS04610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1s21122_RS04615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1s21122_RS04620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1s21122_RS04625	COG1530	ribonuclease E activity
B1s21122_RS04630	COG0772	Belongs to the SEDS family
B1s21122_RS04650	COG1077	Cell shape determining protein MreB Mrl
B1s21122_RS04655	COG0105	UTP biosynthetic process
B1s21122_RS04665	COG0285	dihydrofolate synthase activity
B1s21122_RS04670	COG0525	valine-tRNA ligase activity
B1s21122_RS04675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1s21122_RS04685	COG0740	serine-type endopeptidase activity
B1s21122_RS04690	COG0740	serine-type endopeptidase activity
B1s21122_RS04695	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1s21122_RS04720	COG0698	ribose 5-phosphate isomerase
B1s21122_RS04740	COG0668	transmembrane transport
B1s21122_RS04750	COG2271	Major facilitator Superfamily
B1s21122_RS04770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1s21122_RS04780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1s21122_RS04790	COG0573	inorganic phosphate transmembrane transporter activity
B1s21122_RS04805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1s21122_RS04820	COG0438	transferase activity, transferring glycosyl groups
B1s21122_RS04865	COG0489	protein tyrosine kinase activity
B1s21122_RS04895	COG0372	Belongs to the citrate synthase family
B1s21122_RS04900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B1s21122_RS04905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1s21122_RS04965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B1s21122_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
B1s21122_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
B1s21122_RS04990	COG0148	phosphopyruvate hydratase activity
B1s21122_RS04995	COG0129	dihydroxy-acid dehydratase activity
B1s21122_RS05000	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1s21122_RS05015	COG1131	(ABC) transporter
B1s21122_RS05040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1s21122_RS05050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1s21122_RS05055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1s21122_RS05060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1s21122_RS05065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1s21122_RS05070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1s21122_RS05075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1s21122_RS05080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1s21122_RS05085	COG0356	it plays a direct role in the translocation of protons across the membrane
B1s21122_RS05100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1s21122_RS05105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1s21122_RS05120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1s21122_RS05125	COG0254	rRNA binding
B1s21122_RS05135	COG0083	homoserine kinase activity
B1s21122_RS05140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1s21122_RS05145	COG0460	homoserine dehydrogenase
B1s21122_RS05155	COG0018	arginyl-trna synthetase
B1s21122_RS05180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1s21122_RS05185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1s21122_RS05190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1s21122_RS05205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1s21122_RS05220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1s21122_RS05240	COG1741	Belongs to the pirin family
B1s21122_RS05250	COG0137	argininosuccinate synthase activity
B1s21122_RS05285	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1s21122_RS05285	COG0567	Dehydrogenase, E1 component
B1s21122_RS05310	COG1595	DNA-templated transcription, initiation
B1s21122_RS05315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1s21122_RS05320	COG1162	GTPase activity
B1s21122_RS05335	COG1615	UPF0182 protein
B1s21122_RS05340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1s21122_RS05385	COG0210	DNA helicase
B1s21122_RS05390	COG0210	DNA helicase
B1s21122_RS05395	COG1217	gtp-binding protein TYPA
B1s21122_RS05400	COG0012	GTP binding
B1s21122_RS05405	COG1322	Protein conserved in bacteria
B1s21122_RS05415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1s21122_RS05435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1s21122_RS05455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1s21122_RS05505	COG0148	phosphopyruvate hydratase activity
B1s21122_RS05525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1s21122_RS05530	COG0574	Belongs to the PEP-utilizing enzyme family
B1s21122_RS05530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1s21122_RS05535	COG0193	aminoacyl-tRNA hydrolase activity
B1s21122_RS05540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1s21122_RS05550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1s21122_RS05565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1s21122_RS05570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1s21122_RS05575	COG0084	hydrolase, TatD family'
B1s21122_RS05580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1s21122_RS05610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1s21122_RS05615	COG1960	acyl-CoA dehydrogenase activity
B1s21122_RS05635	COG2409	Drug exporters of the RND superfamily
B1s21122_RS05650	COG0300	oxidoreductase activity
B1s21122_RS05665	COG3447	MASE1 domain protein
B1s21122_RS05665	COG5001	Diguanylate cyclase
B1s21122_RS05665	COG5002	protein histidine kinase activity
B1s21122_RS05680	COG0415	Belongs to the DNA photolyase family
B1s21122_RS05690	COG0259	pyridoxamine-phosphate oxidase activity
B1s21122_RS05695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1s21122_RS05705	COG1278	Cold shock
B1s21122_RS05715	COG0459	protein refolding
B1s21122_RS05725	COG0076	glutamate decarboxylase activity
B1s21122_RS05730	COG0702	epimerase
B1s21122_RS05735	COG1252	NADH dehydrogenase
B1s21122_RS05755	COG0248	Ppx GppA phosphatase
B1s21122_RS05760	COG0494	nUDIX hydrolase
B1s21122_RS05760	COG0406	alpha-ribazole phosphatase activity
B1s21122_RS05765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B1s21122_RS05780	COG0215	cysteine-tRNA ligase activity
B1s21122_RS05790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1s21122_RS05790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1s21122_RS05810	COG5002	protein histidine kinase activity
B1s21122_RS05820	COG0588	phosphoglycerate mutase activity
B1s21122_RS05830	COG1132	(ABC) transporter
B1s21122_RS05835	COG0438	transferase activity, transferring glycosyl groups
B1s21122_RS05845	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B1s21122_RS05870	COG0745	RESPONSE REGULATOR receiver
B1s21122_RS05875	COG0454	-acetyltransferase
B1s21122_RS05875	COG0456	acetyltransferase
B1s21122_RS05890	COG4702	Belongs to the UPF0303 family
B1s21122_RS05895	COG1088	dTDP-glucose 4,6-dehydratase activity
B1s21122_RS05925	COG0009	L-threonylcarbamoyladenylate synthase
B1s21122_RS05955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1s21122_RS05990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1s21122_RS05995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1s21122_RS06000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1s21122_RS06035	COG1610	YqeY-like protein
B1s21122_RS06040	COG1408	metallophosphoesterase
B1s21122_RS06050	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B1s21122_RS06055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1s21122_RS06070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1s21122_RS06095	COG0531	amino acid
B1s21122_RS06100	COG0590	tRNA wobble adenosine to inosine editing
B1s21122_RS06110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1s21122_RS06120	COG0586	Pfam SNARE associated Golgi protein
B1s21122_RS06130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1s21122_RS06145	COG2271	Major facilitator Superfamily
B1s21122_RS06150	COG4948	Mandelate Racemase Muconate Lactonizing
B1s21122_RS06185	COG1216	Glycosyl transferase, family 2
B1s21122_RS06195	COG1216	Glycosyl transferase, family 2
B1s21122_RS06205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1s21122_RS06225	COG1083	cytidylyl-transferase
B1s21122_RS06235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1s21122_RS06265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1s21122_RS06285	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1s21122_RS06295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1s21122_RS06305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B1s21122_RS06310	COG0579	oxidoreductase
B1s21122_RS06315	COG0463	Glycosyl transferase, family 2
B1s21122_RS06320	COG2089	acid synthase
B1s21122_RS06330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1s21122_RS06335	COG1086	Polysaccharide biosynthesis protein