locus-tag	class	description
B1sIIB91_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1sIIB91_RS00010	COG0592	DNA-directed DNA polymerase activity
B1sIIB91_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1sIIB91_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B1sIIB91_RS00025	COG0187	DNA topoisomerase II activity
B1sIIB91_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1sIIB91_RS00055	COG0443	Heat shock 70 kDa protein
B1sIIB91_RS00060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1sIIB91_RS00065	COG0484	heat shock protein binding
B1sIIB91_RS00070	COG0789	Transcriptional regulator
B1sIIB91_RS00075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1sIIB91_RS00080	COG0586	Pfam SNARE associated Golgi protein
B1sIIB91_RS00085	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1sIIB91_RS00090	COG1754	DNA topoisomerase type I activity
B1sIIB91_RS00090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1sIIB91_RS00095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1sIIB91_RS00100	COG0470	DNA polymerase III
B1sIIB91_RS00110	COG0513	Belongs to the DEAD box helicase family
B1sIIB91_RS00145	COG0109	protoheme IX farnesyltransferase activity
B1sIIB91_RS00160	COG0791	NLP P60 protein
B1sIIB91_RS00165	COG0037	tRNA processing
B1sIIB91_RS00180	COG0302	gtp cyclohydrolase
B1sIIB91_RS00185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1sIIB91_RS00190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1sIIB91_RS00200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1sIIB91_RS00205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1sIIB91_RS00215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1sIIB91_RS00220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1sIIB91_RS00225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1sIIB91_RS00235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B1sIIB91_RS00245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1sIIB91_RS00270	COG1061	Type III restriction enzyme res subunit
B1sIIB91_RS00290	COG0406	alpha-ribazole phosphatase activity
B1sIIB91_RS00300	COG0785	Cytochrome C biogenesis protein
B1sIIB91_RS00305	COG1333	cytochrome c biogenesis protein
B1sIIB91_RS00310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1sIIB91_RS00340	COG4948	Mandelate Racemase Muconate Lactonizing
B1sIIB91_RS00345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B1sIIB91_RS00350	COG1169	isochorismate synthase
B1sIIB91_RS00355	COG2226	methyltransferase
B1sIIB91_RS00370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1sIIB91_RS00375	COG0649	NAD binding
B1sIIB91_RS00385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B1sIIB91_RS00390	COG1034	ATP synthesis coupled electron transport
B1sIIB91_RS00395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1sIIB91_RS00400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1sIIB91_RS00405	COG0839	Belongs to the complex I subunit 6 family
B1sIIB91_RS00430	COG0142	geranyltranstransferase activity
B1sIIB91_RS00440	COG1666	GTP binding
B1sIIB91_RS00455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1sIIB91_RS00470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1sIIB91_RS00480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1sIIB91_RS00485	COG0436	Aminotransferase
B1sIIB91_RS00505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1sIIB91_RS00510	COG0081	regulation of translation
B1sIIB91_RS00520	COG0222	ribosome binding
B1sIIB91_RS00525	COG0085	RNA polymerase activity
B1sIIB91_RS00530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1sIIB91_RS00540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1sIIB91_RS00545	COG0049	tRNA binding
B1sIIB91_RS00550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1sIIB91_RS00555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1sIIB91_RS00560	COG0051	transcription antitermination factor activity, RNA binding
B1sIIB91_RS00565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1sIIB91_RS00570	COG0088	Forms part of the polypeptide exit tunnel
B1sIIB91_RS00575	COG0089	rRNA binding
B1sIIB91_RS00580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1sIIB91_RS00590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1sIIB91_RS00595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1sIIB91_RS00600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1sIIB91_RS00605	COG0255	Belongs to the universal ribosomal protein uL29 family
B1sIIB91_RS00610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1sIIB91_RS00615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1sIIB91_RS00620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1sIIB91_RS00625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1sIIB91_RS00630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1sIIB91_RS00635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1sIIB91_RS00640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1sIIB91_RS00645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1sIIB91_RS00650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1sIIB91_RS00655	COG1841	ribosomal large subunit assembly
B1sIIB91_RS00660	COG0200	Binds to the 23S rRNA
B1sIIB91_RS00670	COG0563	adenylate kinase activity
B1sIIB91_RS00675	COG0024	Methionine aminopeptidase
B1sIIB91_RS00680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1sIIB91_RS00685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1sIIB91_RS00690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1sIIB91_RS00695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1sIIB91_RS00700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1sIIB91_RS00710	COG0203	ribosomal protein L17
B1sIIB91_RS00715	COG0101	tRNA pseudouridine synthase activity
B1sIIB91_RS00720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1sIIB91_RS00725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1sIIB91_RS00730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1sIIB91_RS00735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1sIIB91_RS00745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1sIIB91_RS00750	COG0411	ABC transporter
B1sIIB91_RS00780	COG0802	atpase or kinase
B1sIIB91_RS00785	COG0456	acetyltransferase
B1sIIB91_RS00785	COG1214	PFAM Peptidase M22, glycoprotease
B1sIIB91_RS00790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1sIIB91_RS00800	COG0459	protein refolding
B1sIIB91_RS00810	COG0516	GMP reductase activity
B1sIIB91_RS00815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1sIIB91_RS00830	COG0045	succinate-CoA ligase (ADP-forming) activity
B1sIIB91_RS00855	COG0039	L-malate dehydrogenase activity
B1sIIB91_RS00865	COG3842	ATPase activity
B1sIIB91_RS00870	COG1253	flavin adenine dinucleotide binding
B1sIIB91_RS00875	COG0180	Tryptophanyl-tRNA synthetase
B1sIIB91_RS00880	COG1744	ABC transporter substrate-binding protein PnrA-like
B1sIIB91_RS00885	COG3845	ABC transporter
B1sIIB91_RS00890	COG4603	Belongs to the binding-protein-dependent transport system permease family
B1sIIB91_RS00895	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1sIIB91_RS00910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1sIIB91_RS00915	COG1012	belongs to the aldehyde dehydrogenase family
B1sIIB91_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
B1sIIB91_RS00925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B1sIIB91_RS00930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1sIIB91_RS00940	COG0424	maF-like protein
B1sIIB91_RS00945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B1sIIB91_RS00955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1sIIB91_RS00960	COG1316	TRANSCRIPTIONal
B1sIIB91_RS00965	COG1215	transferase activity, transferring glycosyl groups
B1sIIB91_RS00970	COG2171	N-acyltransferase activity
B1sIIB91_RS00995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1sIIB91_RS01005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1sIIB91_RS01010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1sIIB91_RS01015	COG2151	metal-sulfur cluster biosynthetic enzyme
B1sIIB91_RS01015	COG0489	protein tyrosine kinase activity
B1sIIB91_RS01025	COG2239	Acts as a magnesium transporter
B1sIIB91_RS01035	COG0613	PHP domain protein
B1sIIB91_RS01050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1sIIB91_RS01060	COG0215	cysteine-tRNA ligase activity
B1sIIB91_RS01105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1sIIB91_RS01110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1sIIB91_RS01115	COG0745	RESPONSE REGULATOR receiver
B1sIIB91_RS01120	COG5000	phosphorelay sensor kinase activity
B1sIIB91_RS01120	COG5002	protein histidine kinase activity
B1sIIB91_RS01130	COG0653	protein targeting
B1sIIB91_RS01150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1sIIB91_RS01155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1sIIB91_RS01160	COG0626	cystathionine gamma-synthase activity
B1sIIB91_RS01190	COG0277	FAD linked oxidase domain protein
B1sIIB91_RS01195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1sIIB91_RS01205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1sIIB91_RS01215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1sIIB91_RS01220	COG2884	Cell division ATP-binding protein ftsE
B1sIIB91_RS01225	COG2177	Part of the ABC transporter FtsEX involved in
B1sIIB91_RS01230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1sIIB91_RS01245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B1sIIB91_RS01270	COG0531	amino acid
B1sIIB91_RS01275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1sIIB91_RS01345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1sIIB91_RS01350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1sIIB91_RS01360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1sIIB91_RS01365	COG0428	transporter
B1sIIB91_RS01380	COG1070	Carbohydrate kinase
B1sIIB91_RS01400	COG1063	alcohol dehydrogenase
B1sIIB91_RS01405	COG1028	Short-chain dehydrogenase reductase Sdr
B1sIIB91_RS01410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1sIIB91_RS01415	COG1869	D-ribose catabolic process
B1sIIB91_RS01425	COG3962	Belongs to the TPP enzyme family
B1sIIB91_RS01430	COG1082	Xylose isomerase domain protein TIM barrel
B1sIIB91_RS01435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1sIIB91_RS01440	COG3718	enzyme involved in inositol metabolism
B1sIIB91_RS01445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1sIIB91_RS01450	COG0456	acetyltransferase
B1sIIB91_RS01470	COG2318	DinB family
B1sIIB91_RS01475	COG1054	Belongs to the UPF0176 family
B1sIIB91_RS01485	COG0343	queuine tRNA-ribosyltransferase activity
B1sIIB91_RS01490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1sIIB91_RS01495	COG4166	transmembrane transport
B1sIIB91_RS01505	COG0444	Belongs to the ABC transporter superfamily
B1sIIB91_RS01510	COG4608	Belongs to the ABC transporter superfamily
B1sIIB91_RS01515	COG3590	peptidase
B1sIIB91_RS01525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1sIIB91_RS01530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1sIIB91_RS01530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1sIIB91_RS01540	COG1045	serine acetyltransferase
B1sIIB91_RS01555	COG2124	cytochrome p450
B1sIIB91_RS01560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1sIIB91_RS01565	COG1381	Involved in DNA repair and RecF pathway recombination
B1sIIB91_RS01570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1sIIB91_RS01580	COG0423	glycine-tRNA ligase activity
B1sIIB91_RS01595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1sIIB91_RS01640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1sIIB91_RS01670	COG0572	uridine kinase
B1sIIB91_RS01675	COG1070	Carbohydrate kinase
B1sIIB91_RS01690	COG0673	inositol 2-dehydrogenase activity
B1sIIB91_RS01705	COG1278	Cold shock
B1sIIB91_RS01725	COG0438	transferase activity, transferring glycosyl groups
B1sIIB91_RS01730	COG0438	transferase activity, transferring glycosyl groups
B1sIIB91_RS01730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1sIIB91_RS01740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B1sIIB91_RS01750	COG0482	sulfurtransferase activity
B1sIIB91_RS01755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1sIIB91_RS01760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1sIIB91_RS01785	COG0495	leucyl-tRNA aminoacylation
B1sIIB91_RS01810	COG3046	protein related to deoxyribodipyrimidine photolyase
B1sIIB91_RS01845	COG0483	inositol monophosphate 1-phosphatase activity
B1sIIB91_RS01850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1sIIB91_RS01865	COG3842	ATPase activity
B1sIIB91_RS01870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B1sIIB91_RS01875	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1sIIB91_RS01880	COG1177	transmembrane transport
B1sIIB91_RS01885	COG2133	pyrroloquinoline quinone binding
B1sIIB91_RS01895	COG2376	Dihydroxyacetone kinase
B1sIIB91_RS01905	COG1129	ABC transporter
B1sIIB91_RS01910	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1sIIB91_RS01920	COG1363	Peptidase, m42
B1sIIB91_RS01930	COG1063	alcohol dehydrogenase
B1sIIB91_RS01940	COG2084	Dehydrogenase
B1sIIB91_RS01945	COG0434	BtpA family
B1sIIB91_RS01955	COG0667	Aldo Keto reductase
B1sIIB91_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
B1sIIB91_RS01975	COG1063	alcohol dehydrogenase
B1sIIB91_RS01990	COG1175	transmembrane transport
B1sIIB91_RS02030	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B1sIIB91_RS02065	COG0531	amino acid
B1sIIB91_RS02075	COG1012	belongs to the aldehyde dehydrogenase family
B1sIIB91_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
B1sIIB91_RS02085	COG0531	amino acid
B1sIIB91_RS02090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1sIIB91_RS02120	COG4214	carbohydrate transport
B1sIIB91_RS02125	COG1879	ABC-type sugar transport system periplasmic component
B1sIIB91_RS02145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1sIIB91_RS02155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1sIIB91_RS02160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1sIIB91_RS02180	COG0686	Belongs to the AlaDH PNT family
B1sIIB91_RS02190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1sIIB91_RS02195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1sIIB91_RS02210	COG0187	DNA topoisomerase II activity
B1sIIB91_RS02215	COG0488	(ABC) transporter
B1sIIB91_RS02220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1sIIB91_RS02235	COG0483	inositol monophosphate 1-phosphatase activity
B1sIIB91_RS02240	COG0335	large ribosomal subunit rRNA binding
B1sIIB91_RS02245	COG1837	Belongs to the UPF0109 family
B1sIIB91_RS02250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1sIIB91_RS02255	COG0336	Belongs to the RNA methyltransferase TrmD family
B1sIIB91_RS02275	COG0756	dUTP diphosphatase activity
B1sIIB91_RS02290	COG0569	domain protein
B1sIIB91_RS02295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1sIIB91_RS02300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1sIIB91_RS02305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1sIIB91_RS02310	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1sIIB91_RS02310	COG1024	Enoyl-CoA hydratase
B1sIIB91_RS02315	COG0183	Belongs to the thiolase family
B1sIIB91_RS02320	COG0672	)-iron permease
B1sIIB91_RS02355	COG0438	transferase activity, transferring glycosyl groups
B1sIIB91_RS02380	COG1940	carbohydrate kinase activity
B1sIIB91_RS02415	COG3347	Dehydrogenase
B1sIIB91_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
B1sIIB91_RS02420	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B1sIIB91_RS02430	COG0174	glutamine synthetase
B1sIIB91_RS02445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1sIIB91_RS02450	COG0321	lipoyl(octanoyl) transferase activity
B1sIIB91_RS02455	COG2409	Drug exporters of the RND superfamily
B1sIIB91_RS02460	COG0673	inositol 2-dehydrogenase activity
B1sIIB91_RS02465	COG1090	epimerase
B1sIIB91_RS02475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1sIIB91_RS02480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1sIIB91_RS02485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1sIIB91_RS02495	COG0667	Aldo Keto reductase
B1sIIB91_RS02505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1sIIB91_RS02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1sIIB91_RS02525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1sIIB91_RS02530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1sIIB91_RS02545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B1sIIB91_RS02550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1sIIB91_RS02555	COG0723	plastoquinol--plastocyanin reductase activity
B1sIIB91_RS02560	COG2010	Cytochrome c
B1sIIB91_RS02565	COG1845	cytochrome c oxidase, subunit III
B1sIIB91_RS02575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1sIIB91_RS02585	COG2095	MarC family integral membrane protein
B1sIIB91_RS02590	COG3844	kynureninase activity
B1sIIB91_RS02595	COG3483	tryptophan 2,3-dioxygenase activity
B1sIIB91_RS02600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1sIIB91_RS02615	COG3588	fructose-bisphosphate aldolase
B1sIIB91_RS02655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1sIIB91_RS02665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1sIIB91_RS02685	COG1560	Kdo2-lipid A biosynthetic process
B1sIIB91_RS02710	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B1sIIB91_RS02715	COG0217	transcriptional regulatory protein
B1sIIB91_RS02720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1sIIB91_RS02725	COG0632	four-way junction helicase activity
B1sIIB91_RS02730	COG2255	four-way junction helicase activity
B1sIIB91_RS02735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1sIIB91_RS02740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1sIIB91_RS02745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1sIIB91_RS02750	COG1196	nuclear chromosome segregation
B1sIIB91_RS02760	COG0124	histidyl-tRNA synthetase
B1sIIB91_RS02765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1sIIB91_RS02775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1sIIB91_RS02780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1sIIB91_RS02790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1sIIB91_RS02800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1sIIB91_RS02805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1sIIB91_RS02810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1sIIB91_RS02820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1sIIB91_RS02825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1sIIB91_RS02835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1sIIB91_RS02840	COG0540	Belongs to the ATCase OTCase family
B1sIIB91_RS02845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1sIIB91_RS02850	COG0505	Belongs to the CarA family
B1sIIB91_RS02855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1sIIB91_RS02865	COG0167	dihydroorotate dehydrogenase activity
B1sIIB91_RS02870	COG0284	orotidine-5'-phosphate decarboxylase activity
B1sIIB91_RS02875	COG0194	GDP metabolic process
B1sIIB91_RS02880	COG1758	RNA polymerase activity
B1sIIB91_RS02890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1sIIB91_RS02900	COG0242	peptide deformylase activity
B1sIIB91_RS02905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1sIIB91_RS02915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1sIIB91_RS02925	COG1119	ATPase activity
B1sIIB91_RS02930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1sIIB91_RS02935	COG2252	PERMEase
B1sIIB91_RS02940	COG2364	Membrane
B1sIIB91_RS02945	COG1968	undecaprenyl-diphosphatase activity
B1sIIB91_RS02955	COG1064	alcohol dehydrogenase
B1sIIB91_RS02960	COG1435	thymidine kinase activity
B1sIIB91_RS02965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1sIIB91_RS02975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1sIIB91_RS02980	COG0667	Aldo Keto reductase
B1sIIB91_RS02985	COG0406	alpha-ribazole phosphatase activity
B1sIIB91_RS03000	COG0215	cysteine-tRNA ligase activity
B1sIIB91_RS03005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1sIIB91_RS03015	COG0545	Peptidyl-prolyl cis-trans isomerase
B1sIIB91_RS03030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1sIIB91_RS03035	COG0805	protein transport
B1sIIB91_RS03040	COG1597	lipid kinase activity
B1sIIB91_RS03050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1sIIB91_RS03060	COG0463	Glycosyl transferase, family 2
B1sIIB91_RS03065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1sIIB91_RS03065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1sIIB91_RS03090	COG0509	glycine decarboxylation via glycine cleavage system
B1sIIB91_RS03095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1sIIB91_RS03100	COG1160	GTP binding
B1sIIB91_RS03110	COG4401	Chorismate mutase type I
B1sIIB91_RS03115	COG1187	pseudouridine synthase activity
B1sIIB91_RS03120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1sIIB91_RS03125	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1sIIB91_RS03145	COG0504	CTP synthase activity
B1sIIB91_RS03150	COG0497	DNA recombination
B1sIIB91_RS03155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1sIIB91_RS03180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1sIIB91_RS03185	COG0165	Argininosuccinate lyase
B1sIIB91_RS03190	COG1438	arginine binding
B1sIIB91_RS03195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1sIIB91_RS03200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1sIIB91_RS03205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1sIIB91_RS03205	COG0072	phenylalanine-tRNA ligase activity
B1sIIB91_RS03210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1sIIB91_RS03215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1sIIB91_RS03220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1sIIB91_RS03225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1sIIB91_RS03230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1sIIB91_RS03240	COG1132	(ABC) transporter
B1sIIB91_RS03245	COG2151	metal-sulfur cluster biosynthetic enzyme
B1sIIB91_RS03250	COG0822	iron-sulfur transferase activity
B1sIIB91_RS03260	COG0396	ATPase activity
B1sIIB91_RS03270	COG0719	Fe-S assembly protein
B1sIIB91_RS03290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B1sIIB91_RS03295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1sIIB91_RS03300	COG0166	Belongs to the GPI family
B1sIIB91_RS03320	COG0126	phosphoglycerate kinase activity
B1sIIB91_RS03325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1sIIB91_RS03330	COG1481	regulation of sporulation
B1sIIB91_RS03340	COG1660	Displays ATPase and GTPase activities
B1sIIB91_RS03345	COG0322	excinuclease ABC activity
B1sIIB91_RS03350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1sIIB91_RS03355	COG0556	nucleotide-excision repair
B1sIIB91_RS03360	COG0237	dephospho-CoA kinase activity
B1sIIB91_RS03365	COG0539	negative regulation of cytoplasmic translation
B1sIIB91_RS03375	COG2050	protein possibly involved in aromatic compounds catabolism
B1sIIB91_RS03415	COG0469	pyruvate kinase activity
B1sIIB91_RS03425	COG0067	glutamate synthase
B1sIIB91_RS03425	COG0070	glutamate synthase
B1sIIB91_RS03425	COG0069	glutamate synthase activity
B1sIIB91_RS03435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1sIIB91_RS03450	COG0159	tryptophan synthase activity
B1sIIB91_RS03455	COG0133	tryptophan synthase activity
B1sIIB91_RS03460	COG0134	indole-3-glycerol-phosphate synthase activity
B1sIIB91_RS03465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1sIIB91_RS03470	COG0587	DNA-directed DNA polymerase activity
B1sIIB91_RS03490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1sIIB91_RS03500	COG1799	cell septum assembly
B1sIIB91_RS03510	COG1496	oxidoreductase activity
B1sIIB91_RS03515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1sIIB91_RS03525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1sIIB91_RS03530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1sIIB91_RS03540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1sIIB91_RS03545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1sIIB91_RS03550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1sIIB91_RS03555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1sIIB91_RS03560	COG0768	penicillin binding
B1sIIB91_RS03570	COG0275	rRNA processing
B1sIIB91_RS03575	COG2001	Belongs to the MraZ family
B1sIIB91_RS03585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1sIIB91_RS03595	COG0730	response to heat
B1sIIB91_RS03605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1sIIB91_RS03610	COG1054	Belongs to the UPF0176 family
B1sIIB91_RS03630	COG0463	Glycosyl transferase, family 2
B1sIIB91_RS03640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1sIIB91_RS03645	COG0142	geranyltranstransferase activity
B1sIIB91_RS03675	COG0572	uridine kinase
B1sIIB91_RS03680	COG2815	serine threonine protein kinase
B1sIIB91_RS03680	COG0515	serine threonine protein kinase
B1sIIB91_RS03685	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1sIIB91_RS03705	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B1sIIB91_RS03710	COG0205	6-phosphofructokinase activity
B1sIIB91_RS03715	COG2272	Belongs to the type-B carboxylesterase lipase family
B1sIIB91_RS03735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1sIIB91_RS03740	COG0681	Belongs to the peptidase S26 family
B1sIIB91_RS03745	COG0228	four-way junction DNA binding
B1sIIB91_RS03750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1sIIB91_RS03775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1sIIB91_RS03780	COG0571	ribonuclease III activity
B1sIIB91_RS03785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1sIIB91_RS03800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1sIIB91_RS03805	COG0742	ribosomal rna small subunit methyltransferase
B1sIIB91_RS03815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1sIIB91_RS03820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B1sIIB91_RS03845	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1sIIB91_RS03850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1sIIB91_RS03860	COG0776	regulation of translation
B1sIIB91_RS03865	COG0066	3-isopropylmalate dehydratase activity
B1sIIB91_RS03870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1sIIB91_RS03875	COG1414	Transcriptional regulator
B1sIIB91_RS03890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1sIIB91_RS03895	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1sIIB91_RS03905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1sIIB91_RS03915	COG0537	adenosine 5'-monophosphoramidase activity
B1sIIB91_RS03925	COG0484	heat shock protein binding
B1sIIB91_RS03930	COG1420	regulation of RNA biosynthetic process
B1sIIB91_RS03940	COG0481	GTPase activity
B1sIIB91_RS03945	COG0268	Binds directly to 16S ribosomal RNA
B1sIIB91_RS03955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1sIIB91_RS03960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1sIIB91_RS03965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1sIIB91_RS03970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1sIIB91_RS03980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1sIIB91_RS04000	COG1058	Belongs to the CinA family
B1sIIB91_RS04000	COG1546	Belongs to the CinA family
B1sIIB91_RS04010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1sIIB91_RS04020	COG1674	ftsk spoiiie
B1sIIB91_RS04030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1sIIB91_RS04035	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B1sIIB91_RS04055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1sIIB91_RS04060	COG0612	Peptidase, M16
B1sIIB91_RS04065	COG1185	polyribonucleotide nucleotidyltransferase activity
B1sIIB91_RS04070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1sIIB91_RS04080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1sIIB91_RS04085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1sIIB91_RS04090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1sIIB91_RS04090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1sIIB91_RS04105	COG0779	Required for maturation of 30S ribosomal subunits
B1sIIB91_RS04115	COG0442	prolyl-tRNA aminoacylation
B1sIIB91_RS04120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1sIIB91_RS04125	COG0750	zinc metalloprotease
B1sIIB91_RS04130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1sIIB91_RS04140	COG0010	Belongs to the arginase family
B1sIIB91_RS04150	COG1177	transmembrane transport
B1sIIB91_RS04155	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1sIIB91_RS04160	COG3842	ATPase activity
B1sIIB91_RS04170	COG1012	belongs to the aldehyde dehydrogenase family
B1sIIB91_RS04175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1sIIB91_RS04180	COG0575	Belongs to the CDS family
B1sIIB91_RS04185	COG0233	cytoplasmic translational termination
B1sIIB91_RS04190	COG0528	UMP kinase activity
B1sIIB91_RS04195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1sIIB91_RS04200	COG0052	Belongs to the universal ribosomal protein uS2 family
B1sIIB91_RS04210	COG4974	Belongs to the 'phage' integrase family
B1sIIB91_RS04215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1sIIB91_RS04220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1sIIB91_RS04225	COG0473	3-isopropylmalate dehydrogenase activity
B1sIIB91_RS04235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1sIIB91_RS04240	COG0440	acetolactate synthase activity
B1sIIB91_RS04250	COG0129	dihydroxy-acid dehydratase activity
B1sIIB91_RS04255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1sIIB91_RS04260	COG0154	amidase activity
B1sIIB91_RS04265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1sIIB91_RS04270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1sIIB91_RS04280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1sIIB91_RS04285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1sIIB91_RS04290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1sIIB91_RS04295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1sIIB91_RS04300	COG1530	ribonuclease E activity
B1sIIB91_RS04305	COG0772	Belongs to the SEDS family
B1sIIB91_RS04325	COG1077	Cell shape determining protein MreB Mrl
B1sIIB91_RS04330	COG0105	UTP biosynthetic process
B1sIIB91_RS04340	COG0285	dihydrofolate synthase activity
B1sIIB91_RS04345	COG0525	valine-tRNA ligase activity
B1sIIB91_RS04350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1sIIB91_RS04355	COG0740	serine-type endopeptidase activity
B1sIIB91_RS04360	COG0740	serine-type endopeptidase activity
B1sIIB91_RS04365	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1sIIB91_RS04390	COG0698	ribose 5-phosphate isomerase
B1sIIB91_RS04395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1sIIB91_RS04410	COG0668	transmembrane transport
B1sIIB91_RS04420	COG2271	Major facilitator Superfamily
B1sIIB91_RS04440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1sIIB91_RS04450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1sIIB91_RS04460	COG0573	inorganic phosphate transmembrane transporter activity
B1sIIB91_RS04475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B1sIIB91_RS04560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B1sIIB91_RS04600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1sIIB91_RS04605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1sIIB91_RS04610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1sIIB91_RS04615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1sIIB91_RS04620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1sIIB91_RS04625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1sIIB91_RS04630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1sIIB91_RS04635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1sIIB91_RS04640	COG0356	it plays a direct role in the translocation of protons across the membrane
B1sIIB91_RS04655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1sIIB91_RS04660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1sIIB91_RS04665	COG0009	L-threonylcarbamoyladenylate synthase
B1sIIB91_RS04675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1sIIB91_RS04680	COG0254	rRNA binding
B1sIIB91_RS04690	COG0083	homoserine kinase activity
B1sIIB91_RS04695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1sIIB91_RS04700	COG0460	homoserine dehydrogenase
B1sIIB91_RS04710	COG0018	arginyl-trna synthetase
B1sIIB91_RS04735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1sIIB91_RS04740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1sIIB91_RS04745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1sIIB91_RS04760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1sIIB91_RS04775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1sIIB91_RS04800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1sIIB91_RS04820	COG0137	argininosuccinate synthase activity
B1sIIB91_RS04835	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1sIIB91_RS04835	COG0567	Dehydrogenase, E1 component
B1sIIB91_RS04860	COG1595	DNA-templated transcription, initiation
B1sIIB91_RS04865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1sIIB91_RS04870	COG1162	GTPase activity
B1sIIB91_RS04885	COG1615	UPF0182 protein
B1sIIB91_RS04890	COG3480	Lon protease (S16) C-terminal proteolytic domain
B1sIIB91_RS04935	COG0210	DNA helicase
B1sIIB91_RS04940	COG0210	DNA helicase
B1sIIB91_RS04945	COG1217	gtp-binding protein TYPA
B1sIIB91_RS04955	COG1322	Protein conserved in bacteria
B1sIIB91_RS04965	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1sIIB91_RS04980	COG1063	alcohol dehydrogenase
B1sIIB91_RS04985	COG1063	alcohol dehydrogenase
B1sIIB91_RS04990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1sIIB91_RS05015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1sIIB91_RS05035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1sIIB91_RS05050	COG2271	Major facilitator Superfamily
B1sIIB91_RS05080	COG0148	phosphopyruvate hydratase activity
B1sIIB91_RS05100	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1sIIB91_RS05105	COG0193	aminoacyl-tRNA hydrolase activity
B1sIIB91_RS05110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1sIIB91_RS05120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1sIIB91_RS05125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1sIIB91_RS05135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1sIIB91_RS05140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1sIIB91_RS05145	COG0084	hydrolase, TatD family'
B1sIIB91_RS05150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1sIIB91_RS05180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1sIIB91_RS05185	COG1960	acyl-CoA dehydrogenase activity
B1sIIB91_RS05205	COG2409	Drug exporters of the RND superfamily
B1sIIB91_RS05220	COG0300	oxidoreductase activity
B1sIIB91_RS05240	COG0415	Belongs to the DNA photolyase family
B1sIIB91_RS05250	COG0259	pyridoxamine-phosphate oxidase activity
B1sIIB91_RS05255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1sIIB91_RS05285	COG0459	protein refolding
B1sIIB91_RS05295	COG0702	epimerase
B1sIIB91_RS05300	COG1252	NADH dehydrogenase
B1sIIB91_RS05320	COG0248	Ppx GppA phosphatase
B1sIIB91_RS05325	COG0406	alpha-ribazole phosphatase activity
B1sIIB91_RS05325	COG0494	nUDIX hydrolase
B1sIIB91_RS05330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B1sIIB91_RS05345	COG0215	cysteine-tRNA ligase activity
B1sIIB91_RS05350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1sIIB91_RS05350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1sIIB91_RS05370	COG5002	protein histidine kinase activity
B1sIIB91_RS05390	COG0588	phosphoglycerate mutase activity
B1sIIB91_RS05405	COG0438	transferase activity, transferring glycosyl groups
B1sIIB91_RS05410	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B1sIIB91_RS05435	COG0745	RESPONSE REGULATOR receiver
B1sIIB91_RS05440	COG0454	-acetyltransferase
B1sIIB91_RS05440	COG0456	acetyltransferase
B1sIIB91_RS05455	COG4702	Belongs to the UPF0303 family
B1sIIB91_RS05485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1sIIB91_RS05490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1sIIB91_RS05520	COG1215	transferase activity, transferring glycosyl groups
B1sIIB91_RS05545	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B1sIIB91_RS05580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B1sIIB91_RS05590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1sIIB91_RS05595	COG0579	oxidoreductase
B1sIIB91_RS05610	COG0009	L-threonylcarbamoyladenylate synthase
B1sIIB91_RS05665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1sIIB91_RS05670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1sIIB91_RS05675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1sIIB91_RS05685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1sIIB91_RS05700	COG0251	oxidation-reduction process
B1sIIB91_RS05705	COG1610	YqeY-like protein
B1sIIB91_RS05725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1sIIB91_RS05760	COG0531	amino acid
B1sIIB91_RS05765	COG0590	tRNA wobble adenosine to inosine editing
B1sIIB91_RS05775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1sIIB91_RS05780	COG0586	Pfam SNARE associated Golgi protein
B1sIIB91_RS05805	COG0006	proline dipeptidase activity
B1sIIB91_RS05815	COG1053	succinate dehydrogenase
B1sIIB91_RS05835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1sIIB91_RS05840	COG0077	Prephenate dehydratase
B1sIIB91_RS05855	COG2815	serine threonine protein kinase
B1sIIB91_RS05855	COG0515	serine threonine protein kinase
B1sIIB91_RS05870	COG0247	lactate metabolic process
B1sIIB91_RS05870	COG2181	nitrate reductase activity
B1sIIB91_RS05875	COG0745	RESPONSE REGULATOR receiver
B1sIIB91_RS05880	COG2205	protein histidine kinase activity
B1sIIB91_RS05885	COG0717	Belongs to the dCTP deaminase family
B1sIIB91_RS05890	COG1960	acyl-CoA dehydrogenase activity
B1sIIB91_RS05905	COG0305	Participates in initiation and elongation during chromosome replication
B1sIIB91_RS05910	COG0359	binds to the 23S rRNA
B1sIIB91_RS05915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1sIIB91_RS05925	COG0360	Binds together with S18 to 16S ribosomal RNA
B1sIIB91_RS05935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1sIIB91_RS05950	COG0617	tRNA 3'-terminal CCA addition
B1sIIB91_RS05965	COG0728	peptidoglycan biosynthetic process
B1sIIB91_RS05970	COG0492	ferredoxin-NADP+ reductase activity
B1sIIB91_RS05975	COG3118	belongs to the thioredoxin family
B1sIIB91_RS05980	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1sIIB91_RS05980	COG3409	Peptidoglycan-binding domain 1 protein
B1sIIB91_RS05985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1sIIB91_RS05995	COG1192	Involved in chromosome partitioning
B1sIIB91_RS06000	COG0357	Ribosomal RNA small subunit methyltransferase G
B1sIIB91_RS06010	COG0706	membrane insertase activity
B1sIIB91_RS06015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1sIIB91_RS06025	COG0230	Belongs to the bacterial ribosomal protein bL34 family