locus-tag	class	description
Actkin_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Actkin_RS00015	COG0592	DNA-directed DNA polymerase activity
Actkin_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Actkin_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Actkin_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
Actkin_RS00035	COG0187	DNA topoisomerase II activity
Actkin_RS00110	COG0546	phosphoglycolate phosphatase activity
Actkin_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Actkin_RS00155	COG0457	Tetratricopeptide repeat
Actkin_RS00155	COG0705	Rhomboid family
Actkin_RS00170	COG3764	Sortase (surface protein transpeptidase)
Actkin_RS00190	COG2815	serine threonine protein kinase
Actkin_RS00190	COG0515	serine threonine protein kinase
Actkin_RS00195	COG0515	serine threonine protein kinase
Actkin_RS00200	COG0768	penicillin binding
Actkin_RS00215	COG1716	ATPase activity
Actkin_RS00220	COG1716	ATPase activity
Actkin_RS00235	COG0702	epimerase
Actkin_RS00250	COG1309	transcriptional regulator
Actkin_RS00345	COG0667	Aldo Keto reductase
Actkin_RS00350	COG0405	Gamma-glutamyltransferase
Actkin_RS00360	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS00370	COG0477	Major facilitator Superfamily
Actkin_RS00380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS00400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Actkin_RS00405	COG0515	serine threonine protein kinase
Actkin_RS00440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Actkin_RS00445	COG3275	phosphorelay sensor kinase activity
Actkin_RS00465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS00475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS00480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Actkin_RS00480	COG0425	Belongs to the sulfur carrier protein TusA family
Actkin_RS00510	COG0653	protein targeting
Actkin_RS00520	COG1528	Iron-storage protein
Actkin_RS00535	COG3285	dna ligase
Actkin_RS00535	COG1793	dna ligase
Actkin_RS00540	COG3285	dna ligase
Actkin_RS00540	COG1793	dna ligase
Actkin_RS00600	COG1271	oxidase subunit
Actkin_RS00605	COG1294	oxidase, subunit
Actkin_RS00610	COG4988	ABC transporter
Actkin_RS00625	COG1072	(Pantothenic acid kinase))
Actkin_RS00630	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Actkin_RS00640	COG0406	alpha-ribazole phosphatase activity
Actkin_RS00655	COG0477	Major facilitator Superfamily
Actkin_RS00665	COG2197	response regulator
Actkin_RS00715	COG1690	Belongs to the RtcB family
Actkin_RS00735	COG0754	glutathionylspermidine amidase activity
Actkin_RS00740	COG3766	membrane
Actkin_RS00745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Actkin_RS00750	COG0579	oxidoreductase
Actkin_RS00775	COG1216	Glycosyl transferase, family 2
Actkin_RS00780	COG1216	Glycosyl transferase, family 2
Actkin_RS00790	COG0561	phosphatase activity
Actkin_RS00805	COG0671	phosphoesterase, PA-phosphatase related
Actkin_RS00810	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Actkin_RS00825	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS00830	COG0277	FAD linked oxidase domain protein
Actkin_RS00845	COG1216	Glycosyl transferase, family 2
Actkin_RS00870	COG2089	acid synthase
Actkin_RS00875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Actkin_RS00880	COG1086	Polysaccharide biosynthesis protein
Actkin_RS00885	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Actkin_RS00910	COG2234	aminopeptidase activity
Actkin_RS00915	COG2234	aminopeptidase activity
Actkin_RS00925	COG0697	spore germination
Actkin_RS00930	COG1846	Transcriptional regulator
Actkin_RS00960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Actkin_RS00970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Actkin_RS00990	COG0252	asparaginase activity
Actkin_RS00995	COG0596	Alpha beta hydrolase
Actkin_RS01005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS01020	COG2814	Major facilitator Superfamily
Actkin_RS01025	COG3559	Exporter of polyketide antibiotics
Actkin_RS01030	COG1131	(ABC) transporter
Actkin_RS01075	COG0287	Prephenate dehydrogenase
Actkin_RS01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS01100	COG1278	Cold shock
Actkin_RS01115	COG0860	N-Acetylmuramoyl-L-alanine amidase
Actkin_RS01115	COG2247	cell wall binding repeat
Actkin_RS01135	COG0006	proline dipeptidase activity
Actkin_RS01165	COG1473	amidohydrolase
Actkin_RS01180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Actkin_RS01185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Actkin_RS01195	COG0747	negative chemotaxis
Actkin_RS01200	COG0601	transmembrane transport
Actkin_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_RS01215	COG4608	Belongs to the ABC transporter superfamily
Actkin_RS01260	COG0657	acetylesterase activity
Actkin_RS01295	COG1408	metallophosphoesterase
Actkin_RS01300	COG1610	YqeY-like protein
Actkin_RS01305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Actkin_RS01360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_RS01365	COG0592	DNA-directed DNA polymerase activity
Actkin_RS01405	COG0596	Alpha beta hydrolase
Actkin_RS01415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Actkin_RS01430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_RS01435	COG3706	GGDEF domain
Actkin_RS01450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Actkin_RS01455	COG1737	Transcriptional regulator
Actkin_RS01460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Actkin_RS01465	COG3876	Protein conserved in bacteria
Actkin_RS01470	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_RS01520	COG0346	lactoylglutathione lyase activity
Actkin_RS01525	COG1111	helicase
Actkin_RS01525	COG1205	dead DEAH box helicase
Actkin_RS01530	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Actkin_RS01545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Actkin_RS01545	COG1754	DNA topoisomerase type I activity
Actkin_RS01550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Actkin_RS01555	COG0470	DNA polymerase III
Actkin_RS01580	COG0583	DNA-binding transcription factor activity
Actkin_RS01585	COG0515	serine threonine protein kinase
Actkin_RS01585	COG2815	serine threonine protein kinase
Actkin_RS01615	COG0583	DNA-binding transcription factor activity
Actkin_RS01640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Actkin_RS01645	COG2027	D-alanyl-D-alanine carboxypeptidase
Actkin_RS01655	COG0037	tRNA processing
Actkin_RS01685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Actkin_RS01690	COG0302	gtp cyclohydrolase
Actkin_RS01700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Actkin_RS01730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Actkin_RS01735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Actkin_RS01740	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Actkin_RS01790	COG1515	deoxyribonuclease V activity
Actkin_RS01795	COG3903	Transcriptional regulator
Actkin_RS01795	COG3629	intracellular signal transduction
Actkin_RS01825	COG1194	a g-specific adenine glycosylase
Actkin_RS01840	COG1609	Transcriptional regulator
Actkin_RS01850	COG3842	ATPase activity
Actkin_RS01855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Actkin_RS01870	COG0842	Transport permease protein
Actkin_RS01875	COG0842	Transport permease protein
Actkin_RS01875	COG1511	domain protein
Actkin_RS01880	COG1131	(ABC) transporter
Actkin_RS01910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Actkin_RS01915	COG0596	Alpha beta hydrolase
Actkin_RS01930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_RS01935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Actkin_RS01940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Actkin_RS01945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS01955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS01960	COG3903	Transcriptional regulator
Actkin_RS01960	COG3629	intracellular signal transduction
Actkin_RS01965	COG1819	glycosyl
Actkin_RS01980	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Actkin_RS02005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_RS02010	COG0215	cysteine-tRNA ligase activity
Actkin_RS02020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Actkin_RS02025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Actkin_RS02030	COG1329	Transcriptional regulator
Actkin_RS02035	COG2847	Copper chaperone PCu(A)C
Actkin_RS02040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Actkin_RS02060	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Actkin_RS02145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_RS02155	COG4399	Belongs to the UPF0754 family
Actkin_RS02160	COG0456	acetyltransferase
Actkin_RS02165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Actkin_RS02170	COG1917	Cupin 2, conserved barrel domain protein
Actkin_RS02175	COG5285	phytanoyl-CoA dioxygenase
Actkin_RS02180	COG3903	Transcriptional regulator
Actkin_RS02180	COG3629	intracellular signal transduction
Actkin_RS02195	COG2971	BadF BadG BcrA BcrD
Actkin_RS02205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Actkin_RS02210	COG2188	Transcriptional regulator
Actkin_RS02220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Actkin_RS02225	COG0352	thiamine-phosphate diphosphorylase activity
Actkin_RS02230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_RS02230	COG2022	thiamine diphosphate biosynthetic process
Actkin_RS02240	COG2022	thiamine diphosphate biosynthetic process
Actkin_RS02265	COG0351	phosphomethylpyrimidine kinase
Actkin_RS02270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Actkin_RS02280	COG1280	lysine exporter protein (LysE YggA)
Actkin_RS02300	COG0242	peptide deformylase activity
Actkin_RS02305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Actkin_RS02315	COG0688	phosphatidylethanolamine metabolic process
Actkin_RS02335	COG0459	protein refolding
Actkin_RS02345	COG1061	Type III restriction enzyme res subunit
Actkin_RS02360	COG1116	anion transmembrane transporter activity
Actkin_RS02365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Actkin_RS02370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Actkin_RS02385	COG2018	Roadblock/LC7 domain
Actkin_RS02420	COG0315	cyclic pyranopterin monophosphate synthase activity
Actkin_RS02435	COG1388	LysM domain
Actkin_RS02480	COG3304	Inner membrane component domain
Actkin_RS02485	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS02490	COG0546	phosphoglycolate phosphatase activity
Actkin_RS02500	COG1278	Cold shock
Actkin_RS02510	COG2814	Major facilitator Superfamily
Actkin_RS02540	COG2252	PERMEase
Actkin_RS02550	COG2814	Major facilitator Superfamily
Actkin_RS02565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_RS02575	COG1132	(ABC) transporter
Actkin_RS02580	COG1132	(ABC) transporter
Actkin_RS02590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_RS02590	COG2207	Transcriptional regulator
Actkin_RS02620	COG0259	pyridoxamine-phosphate oxidase activity
Actkin_RS02625	COG2814	Major facilitator Superfamily
Actkin_RS02630	COG0640	Transcriptional regulator
Actkin_RS02640	COG2017	converts alpha-aldose to the beta-anomer
Actkin_RS02645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Actkin_RS02655	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS02670	COG0415	Belongs to the DNA photolyase family
Actkin_RS02680	COG1668	transmembrane transport
Actkin_RS02710	COG0277	FAD linked oxidase domain protein
Actkin_RS02720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_RS02740	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS02750	COG1169	isochorismate synthase
Actkin_RS02760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_RS02765	COG2197	response regulator
Actkin_RS02770	COG0477	Major facilitator Superfamily
Actkin_RS02775	COG1022	Amp-dependent synthetase and ligase
Actkin_RS02845	COG1695	Transcriptional regulator
Actkin_RS02850	COG0446	pyridine nucleotide-disulphide oxidoreductase
Actkin_RS02850	COG1902	pentaerythritol trinitrate reductase activity
Actkin_RS02890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Actkin_RS02895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Actkin_RS02900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Actkin_RS02905	COG3706	GGDEF domain
Actkin_RS02910	COG2197	response regulator
Actkin_RS02920	COG1668	transmembrane transport
Actkin_RS02925	COG4152	abc transporter atp-binding protein
Actkin_RS02955	COG3629	intracellular signal transduction
Actkin_RS02955	COG3903	Transcriptional regulator
Actkin_RS03000	COG0018	arginyl-trna synthetase
Actkin_RS03005	COG0124	histidyl-tRNA synthetase
Actkin_RS03010	COG0588	phosphoglycerate mutase activity
Actkin_RS03015	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_RS03025	COG0745	RESPONSE REGULATOR receiver
Actkin_RS03030	COG2205	protein histidine kinase activity
Actkin_RS03035	COG1349	DNA-binding transcription factor activity
Actkin_RS03055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Actkin_RS03065	COG0745	RESPONSE REGULATOR receiver
Actkin_RS03070	COG5002	protein histidine kinase activity
Actkin_RS03075	COG0315	cyclic pyranopterin monophosphate synthase activity
Actkin_RS03075	COG0521	Mo-molybdopterin cofactor biosynthetic process
Actkin_RS03085	COG1970	mechanosensitive ion channel activity
Actkin_RS03100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Actkin_RS03105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Actkin_RS03115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Actkin_RS03180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Actkin_RS03190	COG0515	serine threonine protein kinase
Actkin_RS03200	COG4977	sequence-specific DNA binding
Actkin_RS03240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_RS03245	COG0084	hydrolase, TatD family'
Actkin_RS03255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Actkin_RS03260	COG0193	aminoacyl-tRNA hydrolase activity
Actkin_RS03265	COG3599	regulation of cell shape
Actkin_RS03270	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS03275	COG0488	(ABC) transporter
Actkin_RS03295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Actkin_RS03300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Actkin_RS03305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Actkin_RS03330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Actkin_RS03370	COG2133	pyrroloquinoline quinone binding
Actkin_RS03375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS03400	COG3956	TIGRFAM MazG family protein
Actkin_RS03410	COG0793	Belongs to the peptidase S41A family
Actkin_RS03410	COG4946	Tricorn protease homolog
Actkin_RS03415	COG4106	trans-aconitate 2-methyltransferase activity
Actkin_RS03430	COG0148	phosphopyruvate hydratase activity
Actkin_RS03490	COG0714	Associated with various cellular activities
Actkin_RS03535	COG2267	carboxylic ester hydrolase activity
Actkin_RS03550	COG0183	Belongs to the thiolase family
Actkin_RS03555	COG2755	lipolytic protein G-D-S-L family
Actkin_RS03615	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Actkin_RS03625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Actkin_RS03635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_RS03645	COG3541	Predicted nucleotidyltransferase
Actkin_RS03655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Actkin_RS03665	COG1331	Highly conserved protein containing a thioredoxin domain
Actkin_RS03675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Actkin_RS03690	COG1832	CoA-binding protein
Actkin_RS03700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Actkin_RS03715	COG0419	ATPase involved in DNA repair
Actkin_RS03720	COG0420	3'-5' exonuclease activity
Actkin_RS03735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Actkin_RS03745	COG1570	exodeoxyribonuclease VII activity
Actkin_RS03755	COG1722	exodeoxyribonuclease VII activity
Actkin_RS03780	COG0492	ferredoxin-NADP+ reductase activity
Actkin_RS03785	COG0114	fumarate hydratase activity
Actkin_RS03795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS03805	COG1793	dna ligase
Actkin_RS03815	COG1404	Belongs to the peptidase S8 family
Actkin_RS03820	COG0012	GTP binding
Actkin_RS03830	COG3654	unkown
Actkin_RS03850	COG1840	ABC-type Fe3 transport system, periplasmic component
Actkin_RS03855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Actkin_RS03860	COG3842	ATPase activity
Actkin_RS03875	COG1131	(ABC) transporter
Actkin_RS03885	COG0745	RESPONSE REGULATOR receiver
Actkin_RS03890	COG0642	Histidine kinase
Actkin_RS03900	COG0180	Tryptophanyl-tRNA synthetase
Actkin_RS03910	COG1217	gtp-binding protein TYPA
Actkin_RS03930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_RS03940	COG4608	Belongs to the ABC transporter superfamily
Actkin_RS03945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_RS03960	COG0456	acetyltransferase
Actkin_RS04000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_RS04010	COG1611	Belongs to the LOG family
Actkin_RS04015	COG1611	Belongs to the LOG family
Actkin_RS04025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Actkin_RS04030	COG0463	Glycosyl transferase, family 2
Actkin_RS04035	COG1132	(ABC) transporter
Actkin_RS04045	COG4988	ABC transporter
Actkin_RS04050	COG1294	oxidase, subunit
Actkin_RS04055	COG1271	oxidase subunit
Actkin_RS04080	COG2818	Glycosylase
Actkin_RS04085	COG1024	Enoyl-CoA hydratase
Actkin_RS04100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Actkin_RS04110	COG0297	glycogen (starch) synthase activity
Actkin_RS04115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Actkin_RS04120	COG4122	O-methyltransferase activity
Actkin_RS04125	COG1595	DNA-templated transcription, initiation
Actkin_RS04135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Actkin_RS04140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Actkin_RS04160	COG2239	Acts as a magnesium transporter
Actkin_RS04175	COG2301	Belongs to the HpcH HpaI aldolase family
Actkin_RS04180	COG2301	Belongs to the HpcH HpaI aldolase family
Actkin_RS04185	COG4221	oxidoreductase activity
Actkin_RS04185	COG3321	synthase
Actkin_RS04185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS04230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS04245	COG1595	DNA-templated transcription, initiation
Actkin_RS04335	COG0598	Magnesium transport protein CorA
Actkin_RS04370	COG2095	MarC family integral membrane protein
Actkin_RS04400	COG0513	Belongs to the DEAD box helicase family
Actkin_RS04455	COG1309	transcriptional regulator
Actkin_RS04480	COG0243	molybdopterin cofactor binding
Actkin_RS04485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Actkin_RS04490	COG2223	nitrite transmembrane transporter activity
Actkin_RS04500	COG2146	nitrite reductase [NAD(P)H] activity
Actkin_RS04500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Actkin_RS04535	COG3695	enzyme binding
Actkin_RS04555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Actkin_RS04585	COG0612	Peptidase, M16
Actkin_RS04625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Actkin_RS04655	COG1309	transcriptional regulator
Actkin_RS04665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Actkin_RS04730	COG0557	exoribonuclease II activity
Actkin_RS04750	COG0435	Glutathione S-transferase
Actkin_RS04755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Actkin_RS04760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Actkin_RS04760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Actkin_RS04765	COG0653	protein targeting
Actkin_RS04775	COG0477	Major facilitator Superfamily
Actkin_RS04795	COG0174	glutamine synthetase
Actkin_RS04800	COG0154	amidase activity
Actkin_RS04835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Actkin_RS04905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Actkin_RS04925	COG3480	Lon protease (S16) C-terminal proteolytic domain
Actkin_RS04935	COG1615	UPF0182 protein
Actkin_RS04985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Actkin_RS04990	COG2884	Cell division ATP-binding protein ftsE
Actkin_RS04995	COG2177	Part of the ABC transporter FtsEX involved in
Actkin_RS05000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Actkin_RS05010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Actkin_RS05025	COG4585	Histidine kinase
Actkin_RS05045	COG0737	Belongs to the 5'-nucleotidase family
Actkin_RS05050	COG4585	Histidine kinase
Actkin_RS05055	COG2197	response regulator
Actkin_RS05080	COG0667	Aldo Keto reductase
Actkin_RS05090	COG2226	methyltransferase
Actkin_RS05145	COG0657	acetylesterase activity
Actkin_RS05295	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Actkin_RS05305	COG1643	Atp-dependent helicase
Actkin_RS05340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Actkin_RS05360	COG1476	TRANSCRIPTIONal
Actkin_RS05405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Actkin_RS05415	COG1404	Belongs to the peptidase S8 family
Actkin_RS05425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Actkin_RS05470	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Actkin_RS05475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS05480	COG1104	cysteine desulfurase activity
Actkin_RS05490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Actkin_RS05495	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS05510	COG3764	Sortase (surface protein transpeptidase)
Actkin_RS05520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS05530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Actkin_RS05535	COG0800	Aldolase
Actkin_RS05570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Actkin_RS05575	COG0191	fructose-bisphosphate aldolase activity
Actkin_RS05610	COG1278	Cold shock
Actkin_RS05635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Actkin_RS05640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Actkin_RS05665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Actkin_RS05670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Actkin_RS05700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Actkin_RS05715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Actkin_RS05720	COG1335	isochorismatase
Actkin_RS05725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Actkin_RS05730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Actkin_RS05780	COG0667	Aldo Keto reductase
Actkin_RS05795	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Actkin_RS05805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Actkin_RS05815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Actkin_RS05820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Actkin_RS05895	COG1309	transcriptional regulator
Actkin_RS05950	COG2226	methyltransferase
Actkin_RS05980	COG1316	TRANSCRIPTIONal
Actkin_RS05985	COG4935	Belongs to the peptidase S8 family
Actkin_RS05985	COG2234	aminopeptidase activity
Actkin_RS06005	COG3629	intracellular signal transduction
Actkin_RS06005	COG3903	Transcriptional regulator
Actkin_RS06010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_RS06015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Actkin_RS06020	COG1834	amidinotransferase
Actkin_RS06030	COG0475	glutathione-regulated potassium exporter activity
Actkin_RS06050	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Actkin_RS06060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_RS06085	COG4865	methylaspartate mutase activity
Actkin_RS06090	COG0017	Asparaginyl-tRNA synthetase
Actkin_RS06165	COG1376	ErfK ybiS ycfS ynhG family protein
Actkin_RS06180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Actkin_RS06185	COG0433	COG0433 Predicted ATPase
Actkin_RS06220	COG2814	Major facilitator Superfamily
Actkin_RS06260	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS06265	COG1309	transcriptional regulator
Actkin_RS06270	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS06345	COG3795	YCII-related domain
Actkin_RS06350	COG4941	Belongs to the sigma-70 factor family
Actkin_RS06360	COG4941	Belongs to the sigma-70 factor family
Actkin_RS06370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_RS06375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Actkin_RS06390	COG2132	Multicopper oxidase
Actkin_RS06410	COG0646	methionine synthase
Actkin_RS06410	COG1410	methionine synthase
Actkin_RS06445	COG1653	transport
Actkin_RS06460	COG3903	Transcriptional regulator
Actkin_RS06460	COG3629	intracellular signal transduction
Actkin_RS06465	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Actkin_RS06530	COG1609	Transcriptional regulator
Actkin_RS06535	COG2223	nitrite transmembrane transporter activity
Actkin_RS06560	COG2902	Dehydrogenase
Actkin_RS06580	COG0366	Alpha amylase catalytic
Actkin_RS06590	COG0668	transmembrane transport
Actkin_RS06615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Actkin_RS06625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Actkin_RS06660	COG4552	Acetyltransferase involved in intracellular survival and related
Actkin_RS06695	COG0544	peptidyl-prolyl cis-trans isomerase activity
Actkin_RS06700	COG0740	serine-type endopeptidase activity
Actkin_RS06705	COG0740	serine-type endopeptidase activity
Actkin_RS06720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Actkin_RS06725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Actkin_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS06780	COG0525	valine-tRNA ligase activity
Actkin_RS06785	COG0525	valine-tRNA ligase activity
Actkin_RS06800	COG0477	Major facilitator Superfamily
Actkin_RS06815	COG2175	clavaminate synthase activity
Actkin_RS06820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_RS06820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_RS06830	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Actkin_RS06835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Actkin_RS06845	COG0285	dihydrofolate synthase activity
Actkin_RS06875	COG0105	UTP biosynthetic process
Actkin_RS06880	COG1131	(ABC) transporter
Actkin_RS06920	COG1530	ribonuclease E activity
Actkin_RS06920	COG1530	ribonuclease E activity
Actkin_RS06925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Actkin_RS06930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Actkin_RS06935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Actkin_RS06955	COG0514	ATP-dependent DNA helicase (RecQ)
Actkin_RS06960	COG0778	Nitroreductase
Actkin_RS06960	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Actkin_RS06965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Actkin_RS06970	COG0799	negative regulation of ribosome biogenesis
Actkin_RS06980	COG2755	lipolytic protein G-D-S-L family
Actkin_RS06985	COG1307	EDD domain protein, DegV family
Actkin_RS06995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_RS07030	COG0268	Binds directly to 16S ribosomal RNA
Actkin_RS07080	COG2070	2-Nitropropane dioxygenase
Actkin_RS07090	COG0604	alcohol dehydrogenase
Actkin_RS07105	COG2732	(Barnase) inhibitor
Actkin_RS07120	COG2267	carboxylic ester hydrolase activity
Actkin_RS07140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Actkin_RS07185	COG1309	transcriptional regulator
Actkin_RS07190	COG2124	cytochrome p450
Actkin_RS07210	COG1420	regulation of RNA biosynthetic process
Actkin_RS07215	COG0484	heat shock protein binding
Actkin_RS07225	COG0537	adenosine 5'-monophosphoramidase activity
Actkin_RS07245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Actkin_RS07265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Actkin_RS07280	COG1381	Involved in DNA repair and RecF pathway recombination
Actkin_RS07285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Actkin_RS07295	COG0701	Predicted permease
Actkin_RS07325	COG0423	glycine-tRNA ligase activity
Actkin_RS07355	COG1595	DNA-templated transcription, initiation
Actkin_RS07370	COG4106	trans-aconitate 2-methyltransferase activity
Actkin_RS07410	COG1733	regulation of RNA biosynthetic process
Actkin_RS07440	COG0477	Major facilitator Superfamily
Actkin_RS07475	COG0714	Associated with various cellular activities
Actkin_RS07555	COG0028	Belongs to the TPP enzyme family
Actkin_RS07580	COG1309	transcriptional regulator
Actkin_RS07585	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Actkin_RS07590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Actkin_RS07630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_RS07635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Actkin_RS07650	COG0668	transmembrane transport
Actkin_RS07655	COG3201	nicotinamide mononucleotide transporter
Actkin_RS07660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Actkin_RS07690	COG0586	Pfam SNARE associated Golgi protein
Actkin_RS07695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Actkin_RS07720	COG0321	lipoyl(octanoyl) transferase activity
Actkin_RS07735	COG0508	dehydrogenase complex catalyzes the overall conversion of
Actkin_RS07740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Actkin_RS07750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Actkin_RS07760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Actkin_RS07765	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Actkin_RS07770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Actkin_RS07795	COG0667	Aldo Keto reductase
Actkin_RS07810	COG1929	Belongs to the glycerate kinase type-1 family
Actkin_RS07825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_RS07850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Actkin_RS07860	COG0436	Aminotransferase
Actkin_RS07870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Actkin_RS07880	COG1845	cytochrome c oxidase, subunit III
Actkin_RS07885	COG2010	Cytochrome c
Actkin_RS07895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Actkin_RS07925	COG1876	peptidase activity
Actkin_RS07945	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS07970	COG0003	Pfam Anion-transporting ATPase
Actkin_RS07980	COG1940	carbohydrate kinase activity
Actkin_RS08025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Actkin_RS08035	COG2815	serine threonine protein kinase
Actkin_RS08035	COG0515	serine threonine protein kinase
Actkin_RS08060	COG0142	geranyltranstransferase activity
Actkin_RS08110	COG1201	RNA secondary structure unwinding
Actkin_RS08115	COG0443	Heat shock 70 kDa protein
Actkin_RS08125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Actkin_RS08130	COG2137	regulation of response to DNA damage stimulus
Actkin_RS08145	COG1053	succinate dehydrogenase
Actkin_RS08155	COG0765	amino acid transport
Actkin_RS08160	COG0765	amino acid transport
Actkin_RS08170	COG1126	abc transporter atp-binding protein
Actkin_RS08175	COG0745	RESPONSE REGULATOR receiver
Actkin_RS08190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Actkin_RS08200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Actkin_RS08205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Actkin_RS08215	COG1196	nuclear chromosome segregation
Actkin_RS08230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Actkin_RS08240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Actkin_RS08250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Actkin_RS08255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Actkin_RS08260	COG2321	neutral zinc metallopeptidase
Actkin_RS08270	COG4279	zinc finger
Actkin_RS08275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Actkin_RS08280	COG1505	serine-type exopeptidase activity
Actkin_RS08300	COG2936	dipeptidyl-peptidase activity
Actkin_RS08305	COG0739	heme binding
Actkin_RS08305	COG1196	nuclear chromosome segregation
Actkin_RS08305	COG0741	lytic transglycosylase activity
Actkin_RS08315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Actkin_RS08320	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Actkin_RS08340	COG0123	including yeast histone deacetylase and acetoin utilization protein
Actkin_RS08385	COG1490	D-aminoacyl-tRNA deacylase activity
Actkin_RS08390	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Actkin_RS08400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_RS08415	COG4555	ABC transporter
Actkin_RS08420	COG2313	pseudouridylate synthase activity
Actkin_RS08440	COG4213	ABC transporter substrate-binding protein
Actkin_RS08450	COG4214	carbohydrate transport
Actkin_RS08480	COG0483	inositol monophosphate 1-phosphatase activity
Actkin_RS08500	COG0756	dUTP diphosphatase activity
Actkin_RS08510	COG1280	lysine exporter protein (LysE YggA)
Actkin_RS08540	COG0569	domain protein
Actkin_RS08545	COG0531	amino acid
Actkin_RS08550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Actkin_RS08560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Actkin_RS08580	COG0235	Class ii aldolase
Actkin_RS08585	COG0745	RESPONSE REGULATOR receiver
Actkin_RS08590	COG2205	protein histidine kinase activity
Actkin_RS08600	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_RS08600	COG1024	Enoyl-CoA hydratase
Actkin_RS08605	COG0183	Belongs to the thiolase family
Actkin_RS08625	COG0673	inositol 2-dehydrogenase activity
Actkin_RS08650	COG0693	protein deglycase activity
Actkin_RS08660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Actkin_RS08670	COG3253	May function as heme-dependent peroxidase
Actkin_RS08685	COG3220	belongs to the UPF0276 family
Actkin_RS08735	COG1793	dna ligase
Actkin_RS08770	COG1302	Protein conserved in bacteria
Actkin_RS08815	COG0640	Transcriptional regulator
Actkin_RS08840	COG1132	(ABC) transporter
Actkin_RS08845	COG1132	(ABC) transporter
Actkin_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS08865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Actkin_RS08885	COG4991	sh3 domain protein
Actkin_RS08890	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS08895	COG0488	(ABC) transporter
Actkin_RS08905	COG1132	(ABC) transporter
Actkin_RS08920	COG4821	SIS domain
Actkin_RS08930	COG0596	Alpha beta hydrolase
Actkin_RS08935	COG0596	Alpha beta hydrolase
Actkin_RS08950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Actkin_RS08955	COG1316	TRANSCRIPTIONal
Actkin_RS08970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Actkin_RS08980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_RS08985	COG2326	polyphosphate kinase activity
Actkin_RS08990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Actkin_RS09040	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS09045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_RS09075	COG1309	transcriptional regulator
Actkin_RS09080	COG0183	Belongs to the thiolase family
Actkin_RS09085	COG1024	Enoyl-CoA hydratase
Actkin_RS09085	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_RS09105	COG2351	hydroxyisourate hydrolase activity
Actkin_RS09135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Actkin_RS09150	COG3835	regulator
Actkin_RS09160	COG1120	ATPase activity
Actkin_RS09165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS09175	COG0477	Major facilitator Superfamily
Actkin_RS09180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS09185	COG1535	isochorismatase
Actkin_RS09185	COG3433	isochorismatase activity
Actkin_RS09235	COG0515	serine threonine protein kinase
Actkin_RS09245	COG1132	(ABC) transporter
Actkin_RS09255	COG1132	(ABC) transporter
Actkin_RS09270	COG0395	ABC-type sugar transport system, permease component
Actkin_RS09285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS09295	COG1063	alcohol dehydrogenase
Actkin_RS09305	COG1404	Belongs to the peptidase S8 family
Actkin_RS09325	COG0601	transmembrane transport
Actkin_RS09330	COG0444	Belongs to the ABC transporter superfamily
Actkin_RS09335	COG4608	Belongs to the ABC transporter superfamily
Actkin_RS09365	COG0667	Aldo Keto reductase
Actkin_RS09385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Actkin_RS09425	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS09445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS09455	COG0586	Pfam SNARE associated Golgi protein
Actkin_RS09475	COG1132	(ABC) transporter
Actkin_RS09515	COG1940	carbohydrate kinase activity
Actkin_RS09515	COG1846	Transcriptional regulator
Actkin_RS09525	COG1175	transmembrane transport
Actkin_RS09530	COG0395	ABC-type sugar transport system, permease component
Actkin_RS09535	COG1486	melibiose metabolic process
Actkin_RS09570	COG4941	Belongs to the sigma-70 factor family
Actkin_RS09590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS09620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Actkin_RS09635	COG3568	Endonuclease Exonuclease Phosphatase
Actkin_RS09650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS09665	COG0477	Major facilitator Superfamily
Actkin_RS09725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Actkin_RS09730	COG1115	amino acid carrier protein
Actkin_RS09735	COG0697	spore germination
Actkin_RS09770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Actkin_RS09775	COG1120	ATPase activity
Actkin_RS09780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS09785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS09790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_RS09805	COG1560	Kdo2-lipid A biosynthetic process
Actkin_RS09810	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS09830	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Actkin_RS09850	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Actkin_RS09855	COG0217	transcriptional regulatory protein
Actkin_RS09875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Actkin_RS09880	COG0632	four-way junction helicase activity
Actkin_RS09885	COG2255	four-way junction helicase activity
Actkin_RS09890	COG1862	Preprotein translocase
Actkin_RS09900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Actkin_RS09905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Actkin_RS09910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Actkin_RS09940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Actkin_RS09950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Actkin_RS10015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Actkin_RS10030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Actkin_RS10070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Actkin_RS10085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Actkin_RS10095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Actkin_RS10100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Actkin_RS10105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Actkin_RS10110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Actkin_RS10125	COG0006	proline dipeptidase activity
Actkin_RS10130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Actkin_RS10135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Actkin_RS10150	COG0540	Belongs to the ATCase OTCase family
Actkin_RS10165	COG0505	Belongs to the CarA family
Actkin_RS10175	COG0284	orotidine-5'-phosphate decarboxylase activity
Actkin_RS10185	COG0194	GDP metabolic process
Actkin_RS10190	COG1758	RNA polymerase activity
Actkin_RS10200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Actkin_RS10215	COG0242	peptide deformylase activity
Actkin_RS10220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Actkin_RS10235	COG0252	asparaginase activity
Actkin_RS10250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Actkin_RS10255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Actkin_RS10260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Actkin_RS10265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_RS10270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Actkin_RS10280	COG0137	argininosuccinate synthase activity
Actkin_RS10285	COG0165	Argininosuccinate lyase
Actkin_RS10290	COG2094	Belongs to the DNA glycosylase MPG family
Actkin_RS10295	COG3903	Transcriptional regulator
Actkin_RS10295	COG3629	intracellular signal transduction
Actkin_RS10300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Actkin_RS10325	COG0647	UMP catabolic process
Actkin_RS10340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Actkin_RS10365	COG0504	CTP synthase activity
Actkin_RS10370	COG0494	nUDIX hydrolase
Actkin_RS10390	COG0640	Transcriptional regulator
Actkin_RS10410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Actkin_RS10425	COG0475	glutathione-regulated potassium exporter activity
Actkin_RS10440	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS10450	COG1024	Enoyl-CoA hydratase
Actkin_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS10475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS10500	COG0640	Transcriptional regulator
Actkin_RS10515	COG1160	GTP binding
Actkin_RS10525	COG2197	response regulator
Actkin_RS10530	COG4585	Histidine kinase
Actkin_RS10540	COG4974	Belongs to the 'phage' integrase family
Actkin_RS10630	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS10630	COG1216	Glycosyl transferase, family 2
Actkin_RS10680	COG1518	maintenance of DNA repeat elements
Actkin_RS10925	COG3903	Transcriptional regulator
Actkin_RS10925	COG3629	intracellular signal transduction
Actkin_RS10930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Actkin_RS10995	COG0583	DNA-binding transcription factor activity
Actkin_RS11055	COG2318	DinB family
Actkin_RS11070	COG0596	Alpha beta hydrolase
Actkin_RS11115	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Actkin_RS11125	COG1764	response to oxidative stress
Actkin_RS11135	COG0142	geranyltranstransferase activity
Actkin_RS11155	COG0644	oxidoreductase
Actkin_RS11190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Actkin_RS11235	COG0517	IMP dehydrogenase activity
Actkin_RS11235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Actkin_RS11235	COG0617	tRNA 3'-terminal CCA addition
Actkin_RS11265	COG0515	serine threonine protein kinase
Actkin_RS11280	COG1653	transport
Actkin_RS11330	COG2197	response regulator
Actkin_RS11350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Actkin_RS11375	COG3629	intracellular signal transduction
Actkin_RS11375	COG3903	Transcriptional regulator
Actkin_RS11390	COG0640	Transcriptional regulator
Actkin_RS11400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_RS11425	COG0477	Major facilitator Superfamily
Actkin_RS11445	COG2211	Major facilitator Superfamily
Actkin_RS11465	COG2255	four-way junction helicase activity
Actkin_RS11475	COG0539	negative regulation of cytoplasmic translation
Actkin_RS11480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Actkin_RS11530	COG4585	Histidine kinase
Actkin_RS11535	COG2197	response regulator
Actkin_RS11550	COG0531	amino acid
Actkin_RS11580	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_RS11580	COG1672	PFAM Archaeal ATPase
Actkin_RS11605	COG0574	Belongs to the PEP-utilizing enzyme family
Actkin_RS11605	COG3848	Pyruvate phosphate dikinase
Actkin_RS11630	COG0745	RESPONSE REGULATOR receiver
Actkin_RS11635	COG2205	protein histidine kinase activity
Actkin_RS11640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Actkin_RS11645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Actkin_RS11650	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_RS11710	COG3290	protein histidine kinase activity
Actkin_RS11735	COG3629	intracellular signal transduction
Actkin_RS11735	COG3903	Transcriptional regulator
Actkin_RS11750	COG1309	transcriptional regulator
Actkin_RS11760	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS11765	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS11795	COG0183	Belongs to the thiolase family
Actkin_RS11805	COG1024	Enoyl-CoA hydratase
Actkin_RS11810	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS11835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS11845	COG1404	Belongs to the peptidase S8 family
Actkin_RS11875	COG2076	Multidrug Resistance protein
Actkin_RS11885	COG3795	YCII-related domain
Actkin_RS11890	COG4941	Belongs to the sigma-70 factor family
Actkin_RS11895	COG3153	acetyltransferase
Actkin_RS11910	COG2267	carboxylic ester hydrolase activity
Actkin_RS11920	COG2207	Transcriptional regulator
Actkin_RS11920	COG3708	Transcriptional regulator
Actkin_RS11950	COG3938	Belongs to the proline racemase family
Actkin_RS11955	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS11965	COG2124	cytochrome p450
Actkin_RS11975	COG5001	Diguanylate cyclase
Actkin_RS11990	COG0513	Belongs to the DEAD box helicase family
Actkin_RS12000	COG0740	serine-type endopeptidase activity
Actkin_RS12005	COG0740	serine-type endopeptidase activity
Actkin_RS12020	COG0326	Molecular chaperone. Has ATPase activity
Actkin_RS12030	COG1131	(ABC) transporter
Actkin_RS12045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Actkin_RS12095	COG2124	cytochrome p450
Actkin_RS12110	COG2813	Specifically methylates the guanine in position
Actkin_RS12135	COG2124	cytochrome p450
Actkin_RS12140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_RS12160	COG2124	cytochrome p450
Actkin_RS12220	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_RS12225	COG0463	Glycosyl transferase, family 2
Actkin_RS12270	COG3629	intracellular signal transduction
Actkin_RS12270	COG3903	Transcriptional regulator
Actkin_RS12315	COG3903	Transcriptional regulator
Actkin_RS12315	COG3629	intracellular signal transduction
Actkin_RS12320	COG1595	DNA-templated transcription, initiation
Actkin_RS12345	COG0402	S-adenosylhomocysteine deaminase activity
Actkin_RS12365	COG2197	response regulator
Actkin_RS12390	COG3629	intracellular signal transduction
Actkin_RS12395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Actkin_RS12415	COG3629	intracellular signal transduction
Actkin_RS12415	COG3903	Transcriptional regulator
Actkin_RS12430	COG3629	intracellular signal transduction
Actkin_RS12435	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS12445	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Actkin_RS12465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_RS12475	COG0367	asparagine synthase
Actkin_RS12505	COG2124	cytochrome p450
Actkin_RS12595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Actkin_RS12595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Actkin_RS12605	COG1695	Transcriptional regulator
Actkin_RS12625	COG0531	amino acid
Actkin_RS12695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS12700	COG1404	Belongs to the peptidase S8 family
Actkin_RS12710	COG1733	regulation of RNA biosynthetic process
Actkin_RS12745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_RS12750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_RS12755	COG1215	transferase activity, transferring glycosyl groups
Actkin_RS12765	COG1215	transferase activity, transferring glycosyl groups
Actkin_RS12775	COG1215	transferase activity, transferring glycosyl groups
Actkin_RS12785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS12795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS12810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Actkin_RS12815	COG1573	uracil-dna glycosylase
Actkin_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS12825	COG0248	Ppx GppA phosphatase
Actkin_RS12900	COG0488	(ABC) transporter
Actkin_RS12915	COG1309	transcriptional regulator
Actkin_RS12930	COG0765	amino acid transport
Actkin_RS12950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_RS12950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_RS12950	COG1703	isobutyryl-CoA mutase activity
Actkin_RS12985	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_RS13005	COG2723	6-phospho-beta-galactosidase activity
Actkin_RS13010	COG2211	Major facilitator Superfamily
Actkin_RS13015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Actkin_RS13080	COG0659	secondary active sulfate transmembrane transporter activity
Actkin_RS13100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Actkin_RS13110	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
Actkin_RS13120	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_RS13130	COG2329	Antibiotic biosynthesis monooxygenase
Actkin_RS13140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Actkin_RS13145	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Actkin_RS13150	COG0235	Class ii aldolase
Actkin_RS13155	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Actkin_RS13180	COG0187	DNA topoisomerase II activity
Actkin_RS13185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Actkin_RS13185	COG1372	Participates in initiation and elongation during chromosome replication
Actkin_RS13200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Actkin_RS13230	COG3321	synthase
Actkin_RS13230	COG0604	alcohol dehydrogenase
Actkin_RS13235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Actkin_RS13250	COG1819	glycosyl
Actkin_RS13255	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS13275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Actkin_RS13340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Actkin_RS13350	COG0673	inositol 2-dehydrogenase activity
Actkin_RS13360	COG0395	ABC-type sugar transport system, permease component
Actkin_RS13365	COG1175	transmembrane transport
Actkin_RS13390	COG3835	regulator
Actkin_RS13420	COG0477	Major facilitator Superfamily
Actkin_RS13425	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS13435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_RS13475	COG1132	(ABC) transporter
Actkin_RS13485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_RS13490	COG3275	phosphorelay sensor kinase activity
Actkin_RS13495	COG3279	Response regulator of the LytR AlgR family
Actkin_RS13505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS13515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS13530	COG2030	dehydratase
Actkin_RS13530	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS13560	COG1846	Transcriptional regulator
Actkin_RS13565	COG3433	isochorismatase activity
Actkin_RS13565	COG1535	isochorismatase
Actkin_RS13575	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_RS13580	COG0395	ABC-type sugar transport system, permease component
Actkin_RS13585	COG1175	transmembrane transport
Actkin_RS13590	COG2182	Extracellular solute-binding protein
Actkin_RS13595	COG2188	Transcriptional regulator
Actkin_RS13610	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Actkin_RS13625	COG1414	Transcriptional regulator
Actkin_RS13630	COG0251	oxidation-reduction process
Actkin_RS13655	COG2018	Roadblock/LC7 domain
Actkin_RS13695	COG3033	Beta-eliminating lyase
Actkin_RS13705	COG1253	flavin adenine dinucleotide binding
Actkin_RS13710	COG1253	flavin adenine dinucleotide binding
Actkin_RS13725	COG0745	RESPONSE REGULATOR receiver
Actkin_RS13730	COG4251	negative regulation of phosphorylation
Actkin_RS13735	COG0784	Response regulator, receiver
Actkin_RS13755	COG1643	Atp-dependent helicase
Actkin_RS13785	COG0215	cysteine-tRNA ligase activity
Actkin_RS13805	COG1063	alcohol dehydrogenase
Actkin_RS13810	COG3387	PFAM Glycoside hydrolase 15-related
Actkin_RS13825	COG0140	phosphoribosyl-ATP diphosphatase activity
Actkin_RS13830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Actkin_RS13840	COG1994	Peptidase M50
Actkin_RS13840	COG0517	IMP dehydrogenase activity
Actkin_RS13865	COG1222	aaa ATPase
Actkin_RS13900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Actkin_RS13905	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Actkin_RS13915	COG1404	Belongs to the peptidase S8 family
Actkin_RS13920	COG0583	DNA-binding transcription factor activity
Actkin_RS13925	COG1597	lipid kinase activity
Actkin_RS13930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Actkin_RS13940	COG2378	regulation of single-species biofilm formation
Actkin_RS13950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Actkin_RS13975	COG4552	Acetyltransferase involved in intracellular survival and related
Actkin_RS13985	COG1595	DNA-templated transcription, initiation
Actkin_RS13990	COG1609	Transcriptional regulator
Actkin_RS14000	COG3250	beta-galactosidase activity
Actkin_RS14000	COG5297	Belongs to the glycosyl hydrolase family 6
Actkin_RS14055	COG2318	DinB family
Actkin_RS14085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS14100	COG2205	protein histidine kinase activity
Actkin_RS14105	COG0745	RESPONSE REGULATOR receiver
Actkin_RS14115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Actkin_RS14115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Actkin_RS14125	COG2084	Dehydrogenase
Actkin_RS14130	COG3467	pyridoxamine 5'-phosphate
Actkin_RS14175	COG2197	response regulator
Actkin_RS14180	COG4585	Histidine kinase
Actkin_RS14210	COG1073	alpha beta
Actkin_RS14220	COG4608	Belongs to the ABC transporter superfamily
Actkin_RS14240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_RS14260	COG0583	DNA-binding transcription factor activity
Actkin_RS14270	COG5520	Belongs to the glycosyl hydrolase 30 family
Actkin_RS14270	COG3291	Pkd domain containing protein
Actkin_RS14270	COG4447	cellulose binding
Actkin_RS14310	COG3903	Transcriptional regulator
Actkin_RS14310	COG3629	intracellular signal transduction
Actkin_RS14315	COG1335	isochorismatase
Actkin_RS14325	COG1132	(ABC) transporter
Actkin_RS14325	COG2375	cellular response to nickel ion
Actkin_RS14330	COG1132	(ABC) transporter
Actkin_RS14335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Actkin_RS14345	COG1172	Belongs to the binding-protein-dependent transport system permease family
Actkin_RS14350	COG1172	Belongs to the binding-protein-dependent transport system permease family
Actkin_RS14360	COG1879	ABC-type sugar transport system periplasmic component
Actkin_RS14365	COG1609	Transcriptional regulator
Actkin_RS14380	COG2160	L-arabinose isomerase activity
Actkin_RS14395	COG3940	Belongs to the glycosyl hydrolase 43 family
Actkin_RS14410	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_RS14415	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Actkin_RS14455	COG0154	amidase activity
Actkin_RS14480	COG0346	lactoylglutathione lyase activity
Actkin_RS14520	COG3835	regulator
Actkin_RS14535	COG3209	COG3209 Rhs family protein
Actkin_RS14565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Actkin_RS14570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Actkin_RS14620	COG2755	lipolytic protein G-D-S-L family
Actkin_RS14635	COG3963	phosphatidate phosphatase activity
Actkin_RS14640	COG2409	Drug exporters of the RND superfamily
Actkin_RS14655	COG1113	amino acid transport
Actkin_RS14660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Actkin_RS14675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Actkin_RS14695	COG1595	DNA-templated transcription, initiation
Actkin_RS14715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Actkin_RS14735	COG3251	PFAM MbtH domain protein
Actkin_RS14745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS14755	COG4935	Belongs to the peptidase S8 family
Actkin_RS14755	COG2234	aminopeptidase activity
Actkin_RS14765	COG0861	Integral membrane protein TerC family
Actkin_RS14785	COG0745	RESPONSE REGULATOR receiver
Actkin_RS14790	COG2205	protein histidine kinase activity
Actkin_RS14800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Actkin_RS14810	COG0673	inositol 2-dehydrogenase activity
Actkin_RS14820	COG1175	transmembrane transport
Actkin_RS14825	COG0395	ABC-type sugar transport system, permease component
Actkin_RS14840	COG2011	ABC-type metal ion transport system permease component
Actkin_RS14855	COG3693	PFAM glycoside hydrolase, family 10
Actkin_RS14865	COG1695	Transcriptional regulator
Actkin_RS14875	COG0308	aminopeptidase N
Actkin_RS14885	COG2197	response regulator
Actkin_RS14900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Actkin_RS14910	COG3647	Membrane
Actkin_RS14915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Actkin_RS14920	COG4585	Histidine kinase
Actkin_RS14925	COG2197	response regulator
Actkin_RS14945	COG2226	methyltransferase
Actkin_RS14945	COG2867	negative regulation of translational initiation
Actkin_RS14950	COG2124	cytochrome p450
Actkin_RS14955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Actkin_RS14960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Actkin_RS14980	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Actkin_RS15005	COG1819	glycosyl
Actkin_RS15025	COG1657	PFAM Prenyltransferase squalene oxidase
Actkin_RS15035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_RS15045	COG3903	Transcriptional regulator
Actkin_RS15045	COG3629	intracellular signal transduction
Actkin_RS15055	COG1672	PFAM Archaeal ATPase
Actkin_RS15055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_RS15085	COG0745	RESPONSE REGULATOR receiver
Actkin_RS15090	COG3629	intracellular signal transduction
Actkin_RS15090	COG3903	Transcriptional regulator
Actkin_RS15115	COG0667	Aldo Keto reductase
Actkin_RS15120	COG0515	serine threonine protein kinase
Actkin_RS15135	COG0714	Associated with various cellular activities
Actkin_RS15145	COG5002	protein histidine kinase activity
Actkin_RS15150	COG0745	RESPONSE REGULATOR receiver
Actkin_RS15165	COG0745	RESPONSE REGULATOR receiver
Actkin_RS15180	COG2814	Major facilitator Superfamily
Actkin_RS15235	COG1556	Lactate utilization protein
Actkin_RS15240	COG1139	Iron-sulfur cluster binding protein
Actkin_RS15245	COG0247	lactate metabolic process
Actkin_RS15250	COG2188	Transcriptional regulator
Actkin_RS15255	COG0514	ATP-dependent DNA helicase (RecQ)
Actkin_RS15290	COG1609	Transcriptional regulator
Actkin_RS15295	COG3693	PFAM glycoside hydrolase, family 10
Actkin_RS15295	COG2382	esterase
Actkin_RS15295	COG3507	Belongs to the glycosyl hydrolase 43 family
Actkin_RS15325	COG3845	ABC transporter
Actkin_RS15340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_RS15350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS15355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS15360	COG1120	ATPase activity
Actkin_RS15365	COG1132	(ABC) transporter
Actkin_RS15365	COG2375	cellular response to nickel ion
Actkin_RS15390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS15395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS15455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Actkin_RS15460	COG1136	(ABC) transporter
Actkin_RS15460	COG0577	efflux transmembrane transporter activity
Actkin_RS15470	COG1509	lysine 2,3-aminomutase activity
Actkin_RS15475	COG0604	alcohol dehydrogenase
Actkin_RS15485	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Actkin_RS15490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_RS15495	COG1607	acyl-coa hydrolase
Actkin_RS15500	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS15510	COG0463	Glycosyl transferase, family 2
Actkin_RS15525	COG1435	thymidine kinase activity
Actkin_RS15530	COG2270	Major facilitator Superfamily
Actkin_RS15550	COG5001	Diguanylate cyclase
Actkin_RS15550	COG5002	protein histidine kinase activity
Actkin_RS15555	COG4974	Belongs to the 'phage' integrase family
Actkin_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS15575	COG1595	DNA-templated transcription, initiation
Actkin_RS15580	COG0346	lactoylglutathione lyase activity
Actkin_RS15605	COG0564	pseudouridine synthase activity
Actkin_RS15625	COG0657	acetylesterase activity
Actkin_RS15635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Actkin_RS15670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_RS15725	COG1619	proteins homologs of microcin C7 resistance protein MccF
Actkin_RS15730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_RS15740	COG0542	response to heat
Actkin_RS15750	COG4172	Belongs to the ABC transporter superfamily
Actkin_RS15755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_RS15760	COG0601	transmembrane transport
Actkin_RS15765	COG4533	DNA binding
Actkin_RS15770	COG2362	D-Aminopeptidase
Actkin_RS15790	COG1968	undecaprenyl-diphosphatase activity
Actkin_RS15795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS15800	COG0667	Aldo Keto reductase
Actkin_RS15825	COG0596	Alpha beta hydrolase
Actkin_RS15830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_RS15885	COG1040	competence protein
Actkin_RS15890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Actkin_RS15890	COG0758	DNA mediated transformation
Actkin_RS15980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Actkin_RS15990	COG0517	IMP dehydrogenase activity
Actkin_RS15990	COG0617	tRNA 3'-terminal CCA addition
Actkin_RS15990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Actkin_RS15995	COG0071	Belongs to the small heat shock protein (HSP20) family
Actkin_RS16015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Actkin_RS16020	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Actkin_RS16065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Actkin_RS16075	COG0515	serine threonine protein kinase
Actkin_RS16080	COG0842	Transport permease protein
Actkin_RS16080	COG1131	(ABC) transporter
Actkin_RS16080	COG1716	ATPase activity
Actkin_RS16090	COG3629	intracellular signal transduction
Actkin_RS16090	COG3903	Transcriptional regulator
Actkin_RS16175	COG1309	transcriptional regulator
Actkin_RS16205	COG0366	Alpha amylase catalytic
Actkin_RS16210	COG0395	ABC-type sugar transport system, permease component
Actkin_RS16215	COG1175	transmembrane transport
Actkin_RS16225	COG1846	Transcriptional regulator
Actkin_RS16225	COG1940	carbohydrate kinase activity
Actkin_RS16235	COG0456	acetyltransferase
Actkin_RS16245	COG0583	DNA-binding transcription factor activity
Actkin_RS16250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Actkin_RS16255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS16270	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS16275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_RS16305	COG1917	Cupin 2, conserved barrel domain protein
Actkin_RS16310	COG5285	phytanoyl-CoA dioxygenase
Actkin_RS16320	COG1309	transcriptional regulator
Actkin_RS16340	COG1595	DNA-templated transcription, initiation
Actkin_RS16355	COG2226	methyltransferase
Actkin_RS16365	COG2247	cell wall binding repeat
Actkin_RS16365	COG0860	N-Acetylmuramoyl-L-alanine amidase
Actkin_RS16390	COG2124	cytochrome p450
Actkin_RS16400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Actkin_RS16420	COG2234	aminopeptidase activity
Actkin_RS16420	COG4935	Belongs to the peptidase S8 family
Actkin_RS16430	COG2197	response regulator
Actkin_RS16445	COG2323	membrane
Actkin_RS16450	COG0789	Transcriptional regulator
Actkin_RS16465	COG1021	2,3-dihydroxybenzoate-AMP ligase
Actkin_RS16485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS16485	COG2226	methyltransferase
Actkin_RS16485	COG3433	isochorismatase activity
Actkin_RS16490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS16510	COG1132	(ABC) transporter
Actkin_RS16510	COG2375	cellular response to nickel ion
Actkin_RS16530	COG2124	cytochrome p450
Actkin_RS16545	COG0475	glutathione-regulated potassium exporter activity
Actkin_RS16550	COG1672	PFAM Archaeal ATPase
Actkin_RS16550	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_RS16570	COG2234	aminopeptidase activity
Actkin_RS16570	COG4935	Belongs to the peptidase S8 family
Actkin_RS16610	COG0583	DNA-binding transcription factor activity
Actkin_RS16615	COG2855	membrane
Actkin_RS16635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Actkin_RS16655	COG0596	Alpha beta hydrolase
Actkin_RS16675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS16680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Actkin_RS16690	COG4941	Belongs to the sigma-70 factor family
Actkin_RS16695	COG3795	YCII-related domain
Actkin_RS16710	COG2311	Membrane
Actkin_RS16745	COG0531	amino acid
Actkin_RS16800	COG2066	Belongs to the glutaminase family
Actkin_RS16820	COG2130	NADP-dependent
Actkin_RS16825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Actkin_RS16840	COG0477	Major facilitator Superfamily
Actkin_RS16850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Actkin_RS16880	COG0110	maltose O-acetyltransferase activity
Actkin_RS16905	COG1674	ftsk spoiiie
Actkin_RS16955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Actkin_RS17005	COG1733	regulation of RNA biosynthetic process
Actkin_RS17020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Actkin_RS17025	COG2188	Transcriptional regulator
Actkin_RS17040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Actkin_RS17070	COG4977	sequence-specific DNA binding
Actkin_RS17105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Actkin_RS17120	COG0798	PFAM Bile acid sodium symporter
Actkin_RS17130	COG1408	metallophosphoesterase
Actkin_RS17160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Actkin_RS17180	COG2197	response regulator
Actkin_RS17185	COG4585	Histidine kinase
Actkin_RS17190	COG1136	(ABC) transporter
Actkin_RS17230	COG2197	response regulator
Actkin_RS17240	COG0443	Heat shock 70 kDa protein
Actkin_RS17245	COG0464	growth
Actkin_RS17310	COG1674	ftsk spoiiie
Actkin_RS17335	COG1131	(ABC) transporter
Actkin_RS17360	COG3842	ATPase activity
Actkin_RS17370	COG0395	ABC-type sugar transport system, permease component
Actkin_RS17385	COG1131	(ABC) transporter
Actkin_RS17410	COG1846	Transcriptional regulator
Actkin_RS17415	COG0702	epimerase
Actkin_RS17420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Actkin_RS17435	COG1120	ATPase activity
Actkin_RS17445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS17450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_RS17470	COG0640	Transcriptional regulator
Actkin_RS17475	COG1309	transcriptional regulator
Actkin_RS17500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Actkin_RS17530	COG0641	radical SAM
Actkin_RS17545	COG0789	Transcriptional regulator
Actkin_RS17550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Actkin_RS17555	COG4585	Histidine kinase
Actkin_RS17560	COG2197	response regulator
Actkin_RS17615	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS17620	COG0596	Alpha beta hydrolase
Actkin_RS17650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS17665	COG2018	Roadblock/LC7 domain
Actkin_RS17685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_RS17690	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS17695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_RS17695	COG0723	plastoquinol--plastocyanin reductase activity
Actkin_RS17760	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Actkin_RS17760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Actkin_RS17765	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS17775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Actkin_RS17775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Actkin_RS17780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Actkin_RS17785	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS17795	COG0859	PFAM glycosyl transferase family 9
Actkin_RS17840	COG1295	ribonuclease BN
Actkin_RS17840	COG1959	2 iron, 2 sulfur cluster binding
Actkin_RS17850	COG1846	Transcriptional regulator
Actkin_RS17865	COG1725	Transcriptional regulator
Actkin_RS17870	COG1131	(ABC) transporter
Actkin_RS17880	COG0753	catalase activity
Actkin_RS17890	COG0076	glutamate decarboxylase activity
Actkin_RS17910	COG2409	Drug exporters of the RND superfamily
Actkin_RS17935	COG0542	response to heat
Actkin_RS17940	COG2072	flavoprotein involved in K transport
Actkin_RS17955	COG1247	-acetyltransferase
Actkin_RS17985	COG2226	methyltransferase
Actkin_RS17990	COG2076	Multidrug Resistance protein
Actkin_RS18000	COG1881	PFAM PEBP family protein
Actkin_RS18010	COG0596	Alpha beta hydrolase
Actkin_RS18020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Actkin_RS18085	COG0559	Belongs to the binding-protein-dependent transport system permease family
Actkin_RS18095	COG0683	leucine binding
Actkin_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS18150	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS18165	COG0410	ABC transporter
Actkin_RS18185	COG1309	transcriptional regulator
Actkin_RS18200	COG2124	cytochrome p450
Actkin_RS18240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Actkin_RS18250	COG3706	GGDEF domain
Actkin_RS18375	COG0745	RESPONSE REGULATOR receiver
Actkin_RS18380	COG2205	protein histidine kinase activity
Actkin_RS18385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Actkin_RS18395	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Actkin_RS18415	COG2816	NAD+ diphosphatase activity
Actkin_RS18435	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS18440	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS18450	COG1501	Belongs to the glycosyl hydrolase 31 family
Actkin_RS18460	COG1349	DNA-binding transcription factor activity
Actkin_RS18465	COG1940	carbohydrate kinase activity
Actkin_RS18475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Actkin_RS18500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Actkin_RS18525	COG1674	ftsk spoiiie
Actkin_RS18535	COG0667	Aldo Keto reductase
Actkin_RS18555	COG2318	DinB family
Actkin_RS18580	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_RS18580	COG1672	PFAM Archaeal ATPase
Actkin_RS18590	COG0366	Alpha amylase catalytic
Actkin_RS18595	COG1609	Transcriptional regulator
Actkin_RS18620	COG1486	melibiose metabolic process
Actkin_RS18625	COG0395	ABC-type sugar transport system, permease component
Actkin_RS18630	COG1175	transmembrane transport
Actkin_RS18635	COG1653	transport
Actkin_RS18640	COG1940	carbohydrate kinase activity
Actkin_RS18640	COG1846	Transcriptional regulator
Actkin_RS18650	COG0745	RESPONSE REGULATOR receiver
Actkin_RS18655	COG5002	protein histidine kinase activity
Actkin_RS18680	COG0745	RESPONSE REGULATOR receiver
Actkin_RS18730	COG2197	response regulator
Actkin_RS18740	COG4585	Histidine kinase
Actkin_RS18770	COG1917	Cupin 2, conserved barrel domain protein
Actkin_RS18770	COG4977	sequence-specific DNA binding
Actkin_RS18800	COG1937	Protein conserved in bacteria
Actkin_RS18810	COG1070	Carbohydrate kinase
Actkin_RS18815	COG2115	Belongs to the xylose isomerase family
Actkin_RS18830	COG2814	Major facilitator Superfamily
Actkin_RS18835	COG3118	belongs to the thioredoxin family
Actkin_RS18845	COG0583	DNA-binding transcription factor activity
Actkin_RS18855	COG1953	Uracil, thiamine, allantoin
Actkin_RS18900	COG0009	L-threonylcarbamoyladenylate synthase
Actkin_RS18910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Actkin_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS18925	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS18930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Actkin_RS18940	COG3384	dioxygenase
Actkin_RS18950	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS18955	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS18975	COG0657	acetylesterase activity
Actkin_RS18995	COG1063	alcohol dehydrogenase
Actkin_RS19040	COG1309	transcriptional regulator
Actkin_RS19045	COG1132	(ABC) transporter
Actkin_RS19050	COG1309	transcriptional regulator
Actkin_RS19080	COG4733	cellulase activity
Actkin_RS19080	COG5297	Belongs to the glycosyl hydrolase family 6
Actkin_RS19110	COG1609	Transcriptional regulator
Actkin_RS19115	COG1609	Transcriptional regulator
Actkin_RS19155	COG0655	NAD(P)H dehydrogenase (quinone) activity
Actkin_RS19180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Actkin_RS19185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Actkin_RS19205	COG2188	Transcriptional regulator
Actkin_RS19220	COG2234	aminopeptidase activity
Actkin_RS19220	COG4935	Belongs to the peptidase S8 family
Actkin_RS19265	COG3265	gluconokinase activity
Actkin_RS19280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Actkin_RS19290	COG3447	MASE1 domain protein
Actkin_RS19290	COG5001	Diguanylate cyclase
Actkin_RS19290	COG5002	protein histidine kinase activity
Actkin_RS19295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Actkin_RS19310	COG2151	metal-sulfur cluster biosynthetic enzyme
Actkin_RS19315	COG0822	iron-sulfur transferase activity
Actkin_RS19325	COG0396	ATPase activity
Actkin_RS19330	COG2146	nitrite reductase [NAD(P)H] activity
Actkin_RS19435	COG0109	protoheme IX farnesyltransferase activity
Actkin_RS19445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Actkin_RS19450	COG0166	Belongs to the GPI family
Actkin_RS19465	COG0363	glucosamine-6-phosphate deaminase activity
Actkin_RS19475	COG0477	Major facilitator Superfamily
Actkin_RS19485	COG0584	glycerophosphoryl diester phosphodiesterase
Actkin_RS19500	COG4585	Histidine kinase
Actkin_RS19530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Actkin_RS19535	COG0149	triose-phosphate isomerase activity
Actkin_RS19540	COG0126	phosphoglycerate kinase activity
Actkin_RS19555	COG1481	regulation of sporulation
Actkin_RS19565	COG1660	Displays ATPase and GTPase activities
Actkin_RS19570	COG0322	excinuclease ABC activity
Actkin_RS19585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Actkin_RS19590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Actkin_RS19590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Actkin_RS19610	COG2258	MOSC domain
Actkin_RS19615	COG0494	nUDIX hydrolase
Actkin_RS19630	COG0072	phenylalanine-tRNA ligase activity
Actkin_RS19630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_RS19635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Actkin_RS19640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_RS19645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Actkin_RS19650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Actkin_RS19665	COG4565	transcriptional regulatory protein
Actkin_RS19670	COG3290	protein histidine kinase activity
Actkin_RS19675	COG1301	dicarboxylic acid transport
Actkin_RS19710	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Actkin_RS19730	COG0328	RNA-DNA hybrid ribonuclease activity
Actkin_RS19740	COG1404	Belongs to the peptidase S8 family
Actkin_RS19760	COG0596	Alpha beta hydrolase
Actkin_RS19765	COG2124	cytochrome p450
Actkin_RS19775	COG0673	inositol 2-dehydrogenase activity
Actkin_RS19800	COG1506	peptidase
Actkin_RS19800	COG4946	Tricorn protease homolog
Actkin_RS19800	COG0823	Involved in the tonB-independent uptake of proteins
Actkin_RS19860	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Actkin_RS19890	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS19895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Actkin_RS19945	COG2304	oxidoreductase activity
Actkin_RS19955	COG0714	Associated with various cellular activities
Actkin_RS19960	COG0746	molybdenum cofactor guanylyltransferase activity
Actkin_RS19975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_RS19980	COG2188	Transcriptional regulator
Actkin_RS19985	COG0730	response to heat
Actkin_RS19990	COG1316	TRANSCRIPTIONal
Actkin_RS20005	COG1357	PFAM Pentapeptide repeats (8 copies)
Actkin_RS20025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS20040	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS20040	COG3321	synthase
Actkin_RS20040	COG0604	alcohol dehydrogenase
Actkin_RS20050	COG2197	response regulator
Actkin_RS20055	COG4585	Histidine kinase
Actkin_RS20060	COG0577	efflux transmembrane transporter activity
Actkin_RS20060	COG1136	(ABC) transporter
Actkin_RS20070	COG3883	PFAM NLP P60 protein
Actkin_RS20070	COG0791	NLP P60 protein
Actkin_RS20085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Actkin_RS20090	COG3629	intracellular signal transduction
Actkin_RS20090	COG3903	Transcriptional regulator
Actkin_RS20100	COG0702	epimerase
Actkin_RS20110	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Actkin_RS20120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Actkin_RS20125	COG3572	ergothioneine biosynthetic process
Actkin_RS20130	COG1309	transcriptional regulator
Actkin_RS20145	COG1253	flavin adenine dinucleotide binding
Actkin_RS20160	COG3469	chitinase activity
Actkin_RS20175	COG4585	Histidine kinase
Actkin_RS20180	COG2197	response regulator
Actkin_RS20195	COG2304	oxidoreductase activity
Actkin_RS20240	COG3629	intracellular signal transduction
Actkin_RS20240	COG3903	Transcriptional regulator
Actkin_RS20245	COG0656	L-ascorbic acid biosynthetic process
Actkin_RS20250	COG1185	polyribonucleotide nucleotidyltransferase activity
Actkin_RS20265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Actkin_RS20265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Actkin_RS20285	COG1716	ATPase activity
Actkin_RS20295	COG0693	protein deglycase activity
Actkin_RS20305	COG1024	Enoyl-CoA hydratase
Actkin_RS20375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Actkin_RS20375	COG0237	dephospho-CoA kinase activity
Actkin_RS20385	COG0539	negative regulation of cytoplasmic translation
Actkin_RS20400	COG0667	Aldo Keto reductase
Actkin_RS20410	COG1511	domain protein
Actkin_RS20430	COG0778	Nitroreductase
Actkin_RS20480	COG1366	Belongs to the anti-sigma-factor antagonist family
Actkin_RS20535	COG1234	tRNA 3'-trailer cleavage
Actkin_RS20555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Actkin_RS20570	COG0395	ABC-type sugar transport system, permease component
Actkin_RS20600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS20610	COG0439	Biotin carboxylase
Actkin_RS20620	COG1793	dna ligase
Actkin_RS20630	COG1278	Cold shock
Actkin_RS20675	COG1937	Protein conserved in bacteria
Actkin_RS20695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Actkin_RS20700	COG2226	methyltransferase
Actkin_RS20710	COG0697	spore germination
Actkin_RS20715	COG1846	Transcriptional regulator
Actkin_RS20755	COG2259	Doxx family
Actkin_RS20785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Actkin_RS20800	COG0583	DNA-binding transcription factor activity
Actkin_RS20805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS20810	COG1846	Transcriptional regulator
Actkin_RS20835	COG4257	antibiotic catabolic process
Actkin_RS20840	COG0110	maltose O-acetyltransferase activity
Actkin_RS20855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Actkin_RS20875	COG0596	Alpha beta hydrolase
Actkin_RS20890	COG0596	Alpha beta hydrolase
Actkin_RS20910	COG0488	(ABC) transporter
Actkin_RS20915	COG2124	cytochrome p450
Actkin_RS20980	COG0702	epimerase
Actkin_RS20985	COG3321	synthase
Actkin_RS20985	COG0604	alcohol dehydrogenase
Actkin_RS21025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_RS21025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_RS21030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_RS21045	COG0277	FAD linked oxidase domain protein
Actkin_RS21050	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_RS21065	COG1470	cell adhesion involved in biofilm formation
Actkin_RS21065	COG0366	Alpha amylase catalytic
Actkin_RS21085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Actkin_RS21100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS21115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_RS21120	COG4172	Belongs to the ABC transporter superfamily
Actkin_RS21160	COG1595	DNA-templated transcription, initiation
Actkin_RS21165	COG1252	NADH dehydrogenase
Actkin_RS21170	COG0583	DNA-binding transcription factor activity
Actkin_RS21200	COG1404	Belongs to the peptidase S8 family
Actkin_RS21210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS21230	COG4941	Belongs to the sigma-70 factor family
Actkin_RS21280	COG3973	AAA domain
Actkin_RS21285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_RS21300	COG1120	ATPase activity
Actkin_RS21305	COG4139	cobalamin transport
Actkin_RS21340	COG1120	ATPase activity
Actkin_RS21345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Actkin_RS21370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_RS21375	COG1120	ATPase activity
Actkin_RS21415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS21445	COG0747	negative chemotaxis
Actkin_RS21455	COG0444	Belongs to the ABC transporter superfamily
Actkin_RS21460	COG4172	Belongs to the ABC transporter superfamily
Actkin_RS21520	COG1309	transcriptional regulator
Actkin_RS21525	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS21545	COG1309	transcriptional regulator
Actkin_RS21655	COG0443	Heat shock 70 kDa protein
Actkin_RS21675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Actkin_RS21740	COG3883	PFAM NLP P60 protein
Actkin_RS21740	COG0791	NLP P60 protein
Actkin_RS21790	COG1475	DNA binding
Actkin_RS21825	COG3340	Belongs to the peptidase S51 family
Actkin_RS21865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Actkin_RS21870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Actkin_RS21885	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Actkin_RS21890	COG1518	maintenance of DNA repeat elements
Actkin_RS21915	COG1203	CRISPR-associated helicase, Cas3
Actkin_RS21945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Actkin_RS21950	COG4865	methylaspartate mutase activity
Actkin_RS21970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS21980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS21985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_RS21995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS21995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS22010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Actkin_RS22015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Actkin_RS22020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_RS22060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_RS22065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_RS22100	COG2226	methyltransferase
Actkin_RS22105	COG0586	Pfam SNARE associated Golgi protein
Actkin_RS22110	COG4585	Histidine kinase
Actkin_RS22115	COG2197	response regulator
Actkin_RS22155	COG0644	oxidoreductase
Actkin_RS22160	COG4221	oxidoreductase activity
Actkin_RS22170	COG0402	S-adenosylhomocysteine deaminase activity
Actkin_RS22180	COG0477	Major facilitator Superfamily
Actkin_RS22245	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_RS22265	COG0673	inositol 2-dehydrogenase activity
Actkin_RS22270	COG1609	Transcriptional regulator
Actkin_RS22275	COG0640	Transcriptional regulator
Actkin_RS22290	COG4585	Histidine kinase
Actkin_RS22295	COG2197	response regulator
Actkin_RS22305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Actkin_RS22310	COG4208	sulfate ABC transporter
Actkin_RS22320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Actkin_RS22325	COG1414	Transcriptional regulator
Actkin_RS22375	COG2409	Drug exporters of the RND superfamily
Actkin_RS22385	COG3795	YCII-related domain
Actkin_RS22390	COG4941	Belongs to the sigma-70 factor family
Actkin_RS22400	COG1278	Cold shock
Actkin_RS22405	COG0300	oxidoreductase activity
Actkin_RS22410	COG0667	Aldo Keto reductase
Actkin_RS22425	COG2353	YceI-like domain
Actkin_RS22490	COG0514	ATP-dependent DNA helicase (RecQ)
Actkin_RS22500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Actkin_RS22500	COG2010	Cytochrome c
Actkin_RS22510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Actkin_RS22555	COG3030	protein affecting phage T7 exclusion by the F plasmid
Actkin_RS22560	COG0069	glutamate synthase activity
Actkin_RS22560	COG0067	glutamate synthase
Actkin_RS22560	COG0070	glutamate synthase
Actkin_RS22585	COG1660	Displays ATPase and GTPase activities
Actkin_RS22595	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Actkin_RS22600	COG1846	Transcriptional regulator
Actkin_RS22605	COG1764	response to oxidative stress
Actkin_RS22620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Actkin_RS22635	COG5297	Belongs to the glycosyl hydrolase family 6
Actkin_RS22640	COG1760	l-serine dehydratase
Actkin_RS22645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Actkin_RS22650	COG0509	glycine decarboxylation via glycine cleavage system
Actkin_RS22655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Actkin_RS22660	COG1122	ATPase activity
Actkin_RS22675	COG0310	cobalt ion transport
Actkin_RS22710	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS22725	COG1595	DNA-templated transcription, initiation
Actkin_RS22740	COG2018	Roadblock/LC7 domain
Actkin_RS22755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS22765	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Actkin_RS22770	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Actkin_RS22790	COG1136	(ABC) transporter
Actkin_RS22800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_RS22850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_RS22880	COG2814	Major facilitator Superfamily
Actkin_RS22895	COG1566	PFAM secretion protein HlyD family protein
Actkin_RS22915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Actkin_RS22920	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS22950	COG2197	response regulator
Actkin_RS23070	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS23080	COG2197	response regulator
Actkin_RS23105	COG1946	Acyl-CoA thioesterase
Actkin_RS23130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Actkin_RS23140	COG0067	glutamate synthase
Actkin_RS23140	COG0069	glutamate synthase activity
Actkin_RS23140	COG0070	glutamate synthase
Actkin_RS23150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Actkin_RS23160	COG0159	tryptophan synthase activity
Actkin_RS23165	COG0133	tryptophan synthase activity
Actkin_RS23170	COG0134	indole-3-glycerol-phosphate synthase activity
Actkin_RS23180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Actkin_RS23190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Actkin_RS23200	COG0107	imidazoleglycerol-phosphate synthase activity
Actkin_RS23235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Actkin_RS23240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Actkin_RS23255	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Actkin_RS23280	COG0131	Imidazoleglycerol-phosphate dehydratase
Actkin_RS23285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Actkin_RS23290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Actkin_RS23295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Actkin_RS23315	COG0157	Belongs to the NadC ModD family
Actkin_RS23325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Actkin_RS23350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Actkin_RS23355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Actkin_RS23365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Actkin_RS23380	COG2124	cytochrome p450
Actkin_RS23410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Actkin_RS23415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Actkin_RS23425	COG1872	DUF167
Actkin_RS23450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Actkin_RS23500	COG1799	cell septum assembly
Actkin_RS23545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Actkin_RS23550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Actkin_RS23560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Actkin_RS23565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Actkin_RS23580	COG0768	penicillin binding
Actkin_RS23590	COG0275	rRNA processing
Actkin_RS23595	COG2001	Belongs to the MraZ family
Actkin_RS23600	COG0714	Associated with various cellular activities
Actkin_RS23610	COG1305	Transglutaminase-like
Actkin_RS23625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Actkin_RS23625	COG1796	DNA polymerase
Actkin_RS23670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Actkin_RS23675	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_RS23680	COG1192	Involved in chromosome partitioning
Actkin_RS23685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Actkin_RS23700	COG0167	dihydroorotate dehydrogenase activity
Actkin_RS23705	COG2233	PERMEase
Actkin_RS23720	COG1842	Phage shock protein A
Actkin_RS23725	COG1396	sequence-specific DNA binding
Actkin_RS23730	COG1546	Belongs to the CinA family
Actkin_RS23730	COG1058	Belongs to the CinA family
Actkin_RS23740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Actkin_RS23750	COG0183	Belongs to the thiolase family
Actkin_RS23755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Actkin_RS23770	COG1674	ftsk spoiiie
Actkin_RS23780	COG0366	Alpha amylase catalytic
Actkin_RS23800	COG0659	secondary active sulfate transmembrane transporter activity
Actkin_RS23820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Actkin_RS23825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Actkin_RS23835	COG0515	serine threonine protein kinase
Actkin_RS23860	COG3214	Protein conserved in bacteria
Actkin_RS23865	COG0697	spore germination
Actkin_RS23905	COG0477	Major facilitator Superfamily
Actkin_RS23910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Actkin_RS23920	COG0697	spore germination
Actkin_RS23925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Actkin_RS23930	COG0137	argininosuccinate synthase activity
Actkin_RS23945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Actkin_RS23955	COG1185	polyribonucleotide nucleotidyltransferase activity
Actkin_RS23960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Actkin_RS23980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Actkin_RS23985	COG2223	nitrite transmembrane transporter activity
Actkin_RS24000	COG1271	oxidase subunit
Actkin_RS24015	COG3842	ATPase activity
Actkin_RS24020	COG0395	ABC-type sugar transport system, permease component
Actkin_RS24030	COG1653	transport
Actkin_RS24060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Actkin_RS24070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Actkin_RS24070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Actkin_RS24085	COG0779	Required for maturation of 30S ribosomal subunits
Actkin_RS24125	COG0442	prolyl-tRNA aminoacylation
Actkin_RS24130	COG0235	Class ii aldolase
Actkin_RS24130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Actkin_RS24140	COG3022	response to hydroperoxide
Actkin_RS24150	COG0513	Belongs to the DEAD box helicase family
Actkin_RS24165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Actkin_RS24165	COG1648	precorrin-2 dehydrogenase activity
Actkin_RS24170	COG0745	RESPONSE REGULATOR receiver
Actkin_RS24175	COG1404	Belongs to the peptidase S8 family
Actkin_RS24175	COG4412	M6 family metalloprotease domain protein
Actkin_RS24205	COG0156	8-amino-7-oxononanoate synthase activity
Actkin_RS24235	COG1881	PFAM PEBP family protein
Actkin_RS24250	COG1492	cobalamin metabolic process
Actkin_RS24270	COG0456	acetyltransferase
Actkin_RS24275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Actkin_RS24280	COG0750	zinc metalloprotease
Actkin_RS24285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Actkin_RS24310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Actkin_RS24320	COG2226	methyltransferase
Actkin_RS24335	COG0233	cytoplasmic translational termination
Actkin_RS24340	COG0528	UMP kinase activity
Actkin_RS24345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Actkin_RS24350	COG0052	Belongs to the universal ribosomal protein uS2 family
Actkin_RS24360	COG1191	sigma factor activity
Actkin_RS24380	COG0792	nuclease activity
Actkin_RS24390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Actkin_RS24395	COG0681	Belongs to the peptidase S26 family
Actkin_RS24400	COG0681	Belongs to the peptidase S26 family
Actkin_RS24405	COG0681	Belongs to the peptidase S26 family
Actkin_RS24410	COG0335	large ribosomal subunit rRNA binding
Actkin_RS24415	COG0336	Belongs to the RNA methyltransferase TrmD family
Actkin_RS24420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Actkin_RS24435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Actkin_RS24455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Actkin_RS24465	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Actkin_RS24485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_RS24505	COG0302	gtp cyclohydrolase
Actkin_RS24515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Actkin_RS24525	COG2508	Transcriptional regulator
Actkin_RS24530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_RS24535	COG4266	Belongs to the allantoicase family
Actkin_RS24540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Actkin_RS24550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Actkin_RS24560	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Actkin_RS24565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS24585	COG1196	nuclear chromosome segregation
Actkin_RS24600	COG1254	Belongs to the acylphosphatase family
Actkin_RS24610	COG2340	Cysteine-rich secretory protein family
Actkin_RS24620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Actkin_RS24625	COG0571	ribonuclease III activity
Actkin_RS24630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Actkin_RS24660	COG0742	ribosomal rna small subunit methyltransferase
Actkin_RS24665	COG3973	AAA domain
Actkin_RS24670	COG0640	Transcriptional regulator
Actkin_RS24675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Actkin_RS24690	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Actkin_RS24745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Actkin_RS24755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Actkin_RS24760	COG1461	Dihydroxyacetone kinase
Actkin_RS24770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS24785	COG1595	DNA-templated transcription, initiation
Actkin_RS24795	COG0626	cystathionine gamma-synthase activity
Actkin_RS24800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Actkin_RS24810	COG1920	GTP binding
Actkin_RS24820	COG0406	alpha-ribazole phosphatase activity
Actkin_RS24820	COG0494	nUDIX hydrolase
Actkin_RS24830	COG0066	3-isopropylmalate dehydratase activity
Actkin_RS24835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Actkin_RS24855	COG0546	phosphoglycolate phosphatase activity
Actkin_RS24860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Actkin_RS24910	COG0641	radical SAM
Actkin_RS24935	COG0179	Fumarylacetoacetate (FAA) hydrolase
Actkin_RS24940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Actkin_RS24955	COG0473	3-isopropylmalate dehydrogenase activity
Actkin_RS24985	COG0129	dihydroxy-acid dehydratase activity
Actkin_RS25000	COG0440	acetolactate synthase activity
Actkin_RS25005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Actkin_RS25020	COG2259	Doxx family
Actkin_RS25035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Actkin_RS25045	COG0154	amidase activity
Actkin_RS25050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Actkin_RS25055	COG0849	cell division
Actkin_RS25060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Actkin_RS25070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Actkin_RS25085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Actkin_RS25090	COG1053	succinate dehydrogenase
Actkin_RS25105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Actkin_RS25120	COG0577	efflux transmembrane transporter activity
Actkin_RS25120	COG1136	(ABC) transporter
Actkin_RS25155	COG0482	sulfurtransferase activity
Actkin_RS25165	COG2814	Major facilitator Superfamily
Actkin_RS25180	COG2205	protein histidine kinase activity
Actkin_RS25185	COG0745	RESPONSE REGULATOR receiver
Actkin_RS25210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Actkin_RS25240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS25260	COG2226	methyltransferase
Actkin_RS25265	COG0110	maltose O-acetyltransferase activity
Actkin_RS25305	COG1119	ATPase activity
Actkin_RS25320	COG0135	phosphoribosylanthranilate isomerase activity
Actkin_RS25335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Actkin_RS25340	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Actkin_RS25350	COG0366	Alpha amylase catalytic
Actkin_RS25355	COG0366	Alpha amylase catalytic
Actkin_RS25360	COG0058	SHG alpha-glucan phosphorylase activity
Actkin_RS25390	COG1846	Transcriptional regulator
Actkin_RS25400	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS25415	COG1131	(ABC) transporter
Actkin_RS25425	COG1703	isobutyryl-CoA mutase activity
Actkin_RS25430	COG0183	Belongs to the thiolase family
Actkin_RS25435	COG0346	lactoylglutathione lyase activity
Actkin_RS25445	COG0583	DNA-binding transcription factor activity
Actkin_RS25455	COG3104	oligopeptide transport
Actkin_RS25485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_RS25490	COG4106	trans-aconitate 2-methyltransferase activity
Actkin_RS25515	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_RS25535	COG2376	Dihydroxyacetone kinase
Actkin_RS25545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_RS25550	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Actkin_RS25560	COG0405	Gamma-glutamyltransferase
Actkin_RS25570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_RS25570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_RS25580	COG0765	amino acid transport
Actkin_RS25585	COG0765	amino acid transport
Actkin_RS25590	COG1126	abc transporter atp-binding protein
Actkin_RS25600	COG1024	Enoyl-CoA hydratase
Actkin_RS25620	COG4585	Histidine kinase
Actkin_RS25625	COG2197	response regulator
Actkin_RS25660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Actkin_RS25665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Actkin_RS25670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Actkin_RS25675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Actkin_RS25680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Actkin_RS25685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Actkin_RS25690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Actkin_RS25695	COG0356	it plays a direct role in the translocation of protons across the membrane
Actkin_RS25705	COG2226	methyltransferase
Actkin_RS25735	COG2226	methyltransferase
Actkin_RS25765	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_RS25780	COG0254	rRNA binding
Actkin_RS25805	COG0083	homoserine kinase activity
Actkin_RS25810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Actkin_RS25820	COG0019	diaminopimelate decarboxylase activity
Actkin_RS25825	COG0018	arginyl-trna synthetase
Actkin_RS25850	COG1902	pentaerythritol trinitrate reductase activity
Actkin_RS25855	COG1846	Transcriptional regulator
Actkin_RS25870	COG0659	secondary active sulfate transmembrane transporter activity
Actkin_RS25875	COG3002	Belongs to the UPF0753 family
Actkin_RS25880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Actkin_RS25925	COG3842	ATPase activity
Actkin_RS25955	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Actkin_RS26080	COG3973	AAA domain
Actkin_RS26085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_RS26090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Actkin_RS26100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Actkin_RS26110	COG3629	intracellular signal transduction
Actkin_RS26110	COG3903	Transcriptional regulator
Actkin_RS26140	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS26180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Actkin_RS26200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS26205	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS26230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_RS26235	COG0477	Major facilitator Superfamily
Actkin_RS26260	COG0596	Alpha beta hydrolase
Actkin_RS26265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Actkin_RS26265	COG2755	lipolytic protein G-D-S-L family
Actkin_RS26275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_RS26305	COG2814	Major facilitator Superfamily
Actkin_RS26325	COG2022	thiamine diphosphate biosynthetic process
Actkin_RS26335	COG0159	tryptophan synthase activity
Actkin_RS26340	COG0134	indole-3-glycerol-phosphate synthase activity
Actkin_RS26350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS26360	COG2226	methyltransferase
Actkin_RS26380	COG2124	cytochrome p450
Actkin_RS26420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Actkin_RS26425	COG0569	domain protein
Actkin_RS26440	COG1510	regulation of RNA biosynthetic process
Actkin_RS26525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Actkin_RS26540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_RS26600	COG0395	ABC-type sugar transport system, permease component
Actkin_RS26620	COG0515	serine threonine protein kinase
Actkin_RS26620	COG2815	serine threonine protein kinase
Actkin_RS26645	COG2076	Multidrug Resistance protein
Actkin_RS26650	COG0242	peptide deformylase activity
Actkin_RS26655	COG4948	Mandelate Racemase Muconate Lactonizing
Actkin_RS26665	COG0667	Aldo Keto reductase
Actkin_RS26735	COG5522	Integral membrane protein (intg_mem_TP0381)
Actkin_RS26760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_RS26770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Actkin_RS26775	COG0109	protoheme IX farnesyltransferase activity
Actkin_RS26780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Actkin_RS26800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_RS26810	COG0673	inositol 2-dehydrogenase activity
Actkin_RS26820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS26900	COG2226	methyltransferase
Actkin_RS26905	COG1324	tolerance protein
Actkin_RS26995	COG0626	cystathionine gamma-synthase activity
Actkin_RS27095	COG2226	methyltransferase
Actkin_RS27115	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS27140	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS27150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_RS27155	COG2755	lipolytic protein G-D-S-L family
Actkin_RS27170	COG2203	Gaf domain
Actkin_RS27170	COG5001	Diguanylate cyclase
Actkin_RS27170	COG3706	GGDEF domain
Actkin_RS27170	COG4251	negative regulation of phosphorylation
Actkin_RS27185	COG2755	lipolytic protein G-D-S-L family
Actkin_RS27190	COG2508	Transcriptional regulator
Actkin_RS27190	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Actkin_RS27195	COG0686	Belongs to the AlaDH PNT family
Actkin_RS27220	COG1132	(ABC) transporter
Actkin_RS27235	COG0508	dehydrogenase complex catalyzes the overall conversion of
Actkin_RS27235	COG0567	Dehydrogenase, E1 component
Actkin_RS27260	COG0667	Aldo Keto reductase
Actkin_RS27280	COG1228	amidohydrolase
Actkin_RS27295	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Actkin_RS27300	COG2986	histidine ammonia-lyase
Actkin_RS27315	COG1414	Transcriptional regulator
Actkin_RS27375	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Actkin_RS27400	COG2186	Transcriptional regulator
Actkin_RS27450	COG0406	alpha-ribazole phosphatase activity
Actkin_RS27465	COG1597	lipid kinase activity
Actkin_RS27480	COG5662	AntiSigma factor
Actkin_RS27485	COG1595	DNA-templated transcription, initiation
Actkin_RS27505	COG2135	peptidase activity
Actkin_RS27510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Actkin_RS27515	COG1162	GTPase activity
Actkin_RS27530	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS27555	COG0653	protein targeting
Actkin_RS27565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Actkin_RS27575	COG5002	protein histidine kinase activity
Actkin_RS27580	COG0745	RESPONSE REGULATOR receiver
Actkin_RS27595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Actkin_RS27620	COG1482	cell wall glycoprotein biosynthetic process
Actkin_RS27630	COG2835	tetraacyldisaccharide 4'-kinase activity
Actkin_RS27635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Actkin_RS27660	COG1994	Peptidase M50
Actkin_RS27665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Actkin_RS27670	COG0778	Nitroreductase
Actkin_RS27670	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Actkin_RS27695	COG0662	Cupin 2, conserved barrel domain protein
Actkin_RS27695	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Actkin_RS27715	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS27750	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS27765	COG1316	TRANSCRIPTIONal
Actkin_RS27770	COG1316	TRANSCRIPTIONal
Actkin_RS27790	COG2318	DinB family
Actkin_RS27805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_RS27860	COG2205	protein histidine kinase activity
Actkin_RS27865	COG0745	RESPONSE REGULATOR receiver
Actkin_RS27870	COG0483	inositol monophosphate 1-phosphatase activity
Actkin_RS27895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Actkin_RS27895	COG1473	amidohydrolase
Actkin_RS28220	COG0515	serine threonine protein kinase
Actkin_RS28255	COG4770	biotin carboxylase activity
Actkin_RS28265	COG1301	dicarboxylic acid transport
Actkin_RS28285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_RS28295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Actkin_RS28295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Actkin_RS28330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Actkin_RS28335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Actkin_RS28340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Actkin_RS28370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Actkin_RS28380	COG0702	epimerase
Actkin_RS28385	COG1733	regulation of RNA biosynthetic process
Actkin_RS28425	COG0667	Aldo Keto reductase
Actkin_RS28430	COG0789	Transcriptional regulator
Actkin_RS28440	COG3509	depolymerase
Actkin_RS28445	COG3654	unkown
Actkin_RS28480	COG2226	methyltransferase
Actkin_RS28490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Actkin_RS28495	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS28525	COG3220	belongs to the UPF0276 family
Actkin_RS28555	COG0791	NLP P60 protein
Actkin_RS28555	COG3883	PFAM NLP P60 protein
Actkin_RS28580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Actkin_RS28590	COG0477	Major facilitator Superfamily
Actkin_RS28625	COG1079	Belongs to the binding-protein-dependent transport system permease family
Actkin_RS28630	COG4603	Belongs to the binding-protein-dependent transport system permease family
Actkin_RS28635	COG3845	ABC transporter
Actkin_RS28640	COG1744	ABC transporter substrate-binding protein PnrA-like
Actkin_RS28655	COG2009	succinate dehydrogenase
Actkin_RS28665	COG1053	succinate dehydrogenase
Actkin_RS28670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Actkin_RS28730	COG3507	Belongs to the glycosyl hydrolase 43 family
Actkin_RS28735	COG0673	inositol 2-dehydrogenase activity
Actkin_RS28740	COG1879	ABC-type sugar transport system periplasmic component
Actkin_RS28745	COG1172	Belongs to the binding-protein-dependent transport system permease family
Actkin_RS28750	COG1129	ABC transporter
Actkin_RS28770	COG1940	carbohydrate kinase activity
Actkin_RS28795	COG3903	Transcriptional regulator
Actkin_RS28795	COG3629	intracellular signal transduction
Actkin_RS28815	COG0439	Biotin carboxylase
Actkin_RS28820	COG0511	ligase activity, forming carbon-carbon bonds
Actkin_RS28825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Actkin_RS28825	COG0825	malonyl-CoA metabolic process
Actkin_RS28845	COG2124	cytochrome p450
Actkin_RS28890	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS28905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_RS28910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_RS28940	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS28950	COG1597	lipid kinase activity
Actkin_RS28970	COG3268	Saccharopine dehydrogenase
Actkin_RS28975	COG1940	carbohydrate kinase activity
Actkin_RS28985	COG1686	Belongs to the peptidase S11 family
Actkin_RS28990	COG1295	ribonuclease BN
Actkin_RS28995	COG0180	Tryptophanyl-tRNA synthetase
Actkin_RS29040	COG0477	Major facilitator Superfamily
Actkin_RS29055	COG2815	serine threonine protein kinase
Actkin_RS29055	COG0515	serine threonine protein kinase
Actkin_RS29075	COG0039	L-malate dehydrogenase activity
Actkin_RS29090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Actkin_RS29130	COG0587	DNA-directed DNA polymerase activity
Actkin_RS29175	COG0045	succinate-CoA ligase (ADP-forming) activity
Actkin_RS29190	COG0739	heme binding
Actkin_RS29200	COG1605	Chorismate mutase
Actkin_RS29200	COG0077	Prephenate dehydratase
Actkin_RS29225	COG0515	serine threonine protein kinase
Actkin_RS29230	COG2815	serine threonine protein kinase
Actkin_RS29230	COG0515	serine threonine protein kinase
Actkin_RS29235	COG0583	DNA-binding transcription factor activity
Actkin_RS29265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Actkin_RS29265	COG0519	Catalyzes the synthesis of GMP from XMP
Actkin_RS29270	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_RS29275	COG0277	FAD linked oxidase domain protein
Actkin_RS29285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_RS29295	COG2814	Major facilitator Superfamily
Actkin_RS29310	COG0516	GMP reductase activity
Actkin_RS29345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Actkin_RS29360	COG0459	protein refolding
Actkin_RS29365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Actkin_RS29385	COG3540	Alkaline phosphatase
Actkin_RS29395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Actkin_RS29400	COG0456	acetyltransferase
Actkin_RS29410	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS29415	COG0825	malonyl-CoA metabolic process
Actkin_RS29415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Actkin_RS29420	COG0802	atpase or kinase
Actkin_RS29430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Actkin_RS29480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Actkin_RS29485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Actkin_RS29490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Actkin_RS29510	COG1674	ftsk spoiiie
Actkin_RS29525	COG1404	Belongs to the peptidase S8 family
Actkin_RS29565	COG0203	ribosomal protein L17
Actkin_RS29570	COG0202	RNA polymerase activity
Actkin_RS29575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Actkin_RS29580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Actkin_RS29585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Actkin_RS29590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Actkin_RS29595	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Actkin_RS29600	COG0667	Aldo Keto reductase
Actkin_RS29610	COG0563	adenylate kinase activity
Actkin_RS29620	COG0200	Binds to the 23S rRNA
Actkin_RS29625	COG1841	ribosomal large subunit assembly
Actkin_RS29630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Actkin_RS29635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Actkin_RS29640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Actkin_RS29645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Actkin_RS29650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Actkin_RS29655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Actkin_RS29660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Actkin_RS29665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Actkin_RS29670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Actkin_RS29675	COG0255	Belongs to the universal ribosomal protein uL29 family
Actkin_RS29680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Actkin_RS29685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Actkin_RS29690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Actkin_RS29695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Actkin_RS29700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Actkin_RS29705	COG0089	rRNA binding
Actkin_RS29710	COG0088	Forms part of the polypeptide exit tunnel
Actkin_RS29715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Actkin_RS29720	COG0051	transcription antitermination factor activity, RNA binding
Actkin_RS29725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Actkin_RS29730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Actkin_RS29735	COG0049	tRNA binding
Actkin_RS29740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Actkin_RS29795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Actkin_RS29800	COG0085	RNA polymerase activity
Actkin_RS29820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Actkin_RS29845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Actkin_RS29890	COG0081	regulation of translation
Actkin_RS29910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS29920	COG2030	dehydratase
Actkin_RS29985	COG2267	carboxylic ester hydrolase activity
Actkin_RS30005	COG1666	GTP binding
Actkin_RS30020	COG0501	Belongs to the peptidase M48B family
Actkin_RS30045	COG1834	amidinotransferase
Actkin_RS30050	COG1522	sequence-specific DNA binding
Actkin_RS30060	COG0674	pyruvate-flavodoxin oxidoreductase activity
Actkin_RS30060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Actkin_RS30065	COG1013	pyruvate-flavodoxin oxidoreductase activity
Actkin_RS30080	COG0142	geranyltranstransferase activity
Actkin_RS30085	COG1007	ATP synthesis coupled electron transport
Actkin_RS30100	COG0713	ATP synthesis coupled electron transport
Actkin_RS30105	COG0839	Belongs to the complex I subunit 6 family
Actkin_RS30110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Actkin_RS30115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Actkin_RS30120	COG1034	ATP synthesis coupled electron transport
Actkin_RS30135	COG0649	NAD binding
Actkin_RS30140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Actkin_RS30145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Actkin_RS30155	COG0644	oxidoreductase
Actkin_RS30185	COG2226	methyltransferase
Actkin_RS30190	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS30195	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS30210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Actkin_RS30215	COG2151	metal-sulfur cluster biosynthetic enzyme
Actkin_RS30220	COG3396	Phenylacetate-CoA oxygenase
Actkin_RS30225	COG3460	Phenylacetate-CoA oxygenase
Actkin_RS30230	COG3396	Phenylacetate-CoA oxygenase
Actkin_RS30245	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Actkin_RS30250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Actkin_RS30270	COG3629	intracellular signal transduction
Actkin_RS30270	COG3903	Transcriptional regulator
Actkin_RS30310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Actkin_RS30325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Actkin_RS30335	COG0785	Cytochrome C biogenesis protein
Actkin_RS30345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Actkin_RS30350	COG0406	alpha-ribazole phosphatase activity
Actkin_RS30355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Actkin_RS30405	COG1648	precorrin-2 dehydrogenase activity
Actkin_RS30405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Actkin_RS30410	COG0181	hydroxymethylbilane synthase activity
Actkin_RS30415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Actkin_RS30420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Actkin_RS30440	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_RS30445	COG1595	DNA-templated transcription, initiation
Actkin_RS30475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Actkin_RS30485	COG0506	proline dehydrogenase activity
Actkin_RS30490	COG1082	Xylose isomerase domain protein TIM barrel
Actkin_RS30510	COG5002	protein histidine kinase activity
Actkin_RS30515	COG0588	phosphoglycerate mutase activity
Actkin_RS30530	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS30540	COG1376	ErfK ybiS ycfS ynhG family protein
Actkin_RS30550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Actkin_RS30565	COG2197	response regulator
Actkin_RS30610	COG3973	AAA domain
Actkin_RS30615	COG2843	Capsule synthesis protein
Actkin_RS30685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Actkin_RS30690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Actkin_RS30695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Actkin_RS30695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Actkin_RS30705	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS30735	COG1136	(ABC) transporter
Actkin_RS30755	COG2733	membrane
Actkin_RS30770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS30780	COG0387	Pfam Sodium calcium exchanger
Actkin_RS30810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Actkin_RS30815	COG0438	transferase activity, transferring glycosyl groups
Actkin_RS30855	COG2244	polysaccharide biosynthetic process
Actkin_RS30860	COG0463	Glycosyl transferase, family 2
Actkin_RS30865	COG1595	DNA-templated transcription, initiation
Actkin_RS30910	COG0367	asparagine synthase
Actkin_RS30930	COG0673	inositol 2-dehydrogenase activity
Actkin_RS30965	COG1278	Cold shock
Actkin_RS30985	COG1408	metallophosphoesterase
Actkin_RS30990	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS30995	COG0515	serine threonine protein kinase
Actkin_RS31035	COG2255	four-way junction helicase activity
Actkin_RS31090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Actkin_RS31125	COG0673	inositol 2-dehydrogenase activity
Actkin_RS31160	COG0704	Plays a role in the regulation of phosphate uptake
Actkin_RS31165	COG1316	TRANSCRIPTIONal
Actkin_RS31205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Actkin_RS31225	COG0456	acetyltransferase
Actkin_RS31225	COG0454	-acetyltransferase
Actkin_RS31230	COG0745	RESPONSE REGULATOR receiver
Actkin_RS31250	COG2897	thiosulfate sulfurtransferase activity
Actkin_RS31260	COG4044	May play a role in the intracellular transport of hydrophobic ligands
Actkin_RS31280	COG0735	belongs to the Fur family
Actkin_RS31290	COG3246	L-lysine catabolic process to acetate
Actkin_RS31330	COG3290	protein histidine kinase activity
Actkin_RS31335	COG4565	transcriptional regulatory protein
Actkin_RS31340	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Actkin_RS31405	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_RS31415	COG2814	Major facilitator Superfamily
Actkin_RS31435	COG2271	Major facilitator Superfamily
Actkin_RS31445	COG2181	nitrate reductase activity
Actkin_RS31445	COG0247	lactate metabolic process
Actkin_RS31480	COG0542	response to heat
Actkin_RS31490	COG2871	sodium ion transport
Actkin_RS31495	COG0789	Transcriptional regulator
Actkin_RS31500	COG0484	heat shock protein binding
Actkin_RS31505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Actkin_RS31510	COG0443	Heat shock 70 kDa protein
Actkin_RS31530	COG0277	FAD linked oxidase domain protein
Actkin_RS31555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Actkin_RS31565	COG0586	Pfam SNARE associated Golgi protein
Actkin_RS31575	COG1609	Transcriptional regulator
Actkin_RS31590	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS31600	COG0243	molybdopterin cofactor binding
Actkin_RS31615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_RS31640	COG4221	oxidoreductase activity
Actkin_RS31675	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS31695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Actkin_RS31705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Actkin_RS31720	COG1595	DNA-templated transcription, initiation
Actkin_RS31730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Actkin_RS31740	COG0436	Aminotransferase
Actkin_RS31795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Actkin_RS31800	COG0047	phosphoribosylformylglycinamidine synthase activity
Actkin_RS31805	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Actkin_RS31815	COG0456	acetyltransferase
Actkin_RS31820	COG1960	acyl-CoA dehydrogenase activity
Actkin_RS31825	COG2197	response regulator
Actkin_RS31865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Actkin_RS31905	COG0584	glycerophosphoryl diester phosphodiesterase
Actkin_RS31910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Actkin_RS31930	COG1309	transcriptional regulator
Actkin_RS31945	COG0508	dehydrogenase complex catalyzes the overall conversion of
Actkin_RS31950	COG0022	dehydrogenase e1 component
Actkin_RS31960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_RS31965	COG2319	Wd-40 repeat
Actkin_RS31980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Actkin_RS31985	COG0765	amino acid transport
Actkin_RS32000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Actkin_RS32010	COG4935	Belongs to the peptidase S8 family
Actkin_RS32010	COG2234	aminopeptidase activity
Actkin_RS32015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Actkin_RS32040	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS32045	COG0183	Belongs to the thiolase family
Actkin_RS32085	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Actkin_RS32095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Actkin_RS32100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Actkin_RS32110	COG4585	Histidine kinase
Actkin_RS32120	COG3311	Transcriptional regulator
Actkin_RS32130	COG1569	PIN domain
Actkin_RS32135	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_RS32165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Actkin_RS32170	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
Actkin_RS32175	COG0402	S-adenosylhomocysteine deaminase activity
Actkin_RS32190	COG4221	oxidoreductase activity
Actkin_RS32200	COG1260	myo-inositol-1-phosphate synthase
Actkin_RS32215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Actkin_RS32250	COG0360	Binds together with S18 to 16S ribosomal RNA
Actkin_RS32260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Actkin_RS32265	COG0359	binds to the 23S rRNA
Actkin_RS32345	COG1063	alcohol dehydrogenase
Actkin_RS32355	COG0583	DNA-binding transcription factor activity
Actkin_RS32370	COG2409	Drug exporters of the RND superfamily
Actkin_RS32375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_RS32385	COG0495	leucyl-tRNA aminoacylation
Actkin_RS32395	COG1678	Uncharacterized ACR, COG1678
Actkin_RS32405	COG0617	tRNA 3'-terminal CCA addition
Actkin_RS32430	COG1595	DNA-templated transcription, initiation
Actkin_RS32445	COG3118	belongs to the thioredoxin family
Actkin_RS32445	COG0492	ferredoxin-NADP+ reductase activity
Actkin_RS32450	COG3409	Peptidoglycan-binding domain 1 protein
Actkin_RS32450	COG0860	N-Acetylmuramoyl-L-alanine amidase
Actkin_RS32460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_RS32465	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_RS32480	COG1192	Involved in chromosome partitioning
Actkin_RS32485	COG0357	Ribosomal RNA small subunit methyltransferase G
Actkin_RS32495	COG0706	membrane insertase activity
Actkin_RS32500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Actkin_RS32505	COG0594	ribonuclease P activity
Actkin_RS32510	COG0230	Belongs to the bacterial ribosomal protein bL34 family