locus-tag class description HUT06_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HUT06_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT06_RS00015 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT06_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT06_RS00025 ENOG4105K7N UPF0232 protein HUT06_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT06_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT06_RS00040 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) HUT06_RS00075 ENOG4107Y9U Membrane HUT06_RS00085 ENOG4108W6C Dehydrogenase HUT06_RS00110 ENOG4105NPE arsR family transcriptional regulator HUT06_RS00140 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT06_RS00145 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT06_RS00155 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT06_RS00160 ENOG4105EV4 Multidrug resistance protein mdtH HUT06_RS00165 ENOG4105CPF Cell wall formation (By similarity) HUT06_RS00215 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HUT06_RS00220 ENOG4105C1J atp-dependent rna helicase HUT06_RS00245 ENOG4105ZJT Cell division protein CrgA HUT06_RS00255 ENOG4108U4N (sortase) family HUT06_RS00270 ENOG4107TPY serine threonine protein kinase HUT06_RS00275 ENOG4105CJN penicillin-binding protein HUT06_RS00290 ENOG4105HZM Fha domain containing protein HUT06_RS00350 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT06_RS00415 ENOG4107TMB Transcriptional regulator HUT06_RS00455 ENOG410905P Pyridoxamine 5-phosphate HUT06_RS00465 ENOG4108RWP Major Facilitator Superfamily protein HUT06_RS00475 ENOG4105EMU Dehydrogenase HUT06_RS00535 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS00575 ENOG4105KVH Transcriptional regulator HUT06_RS00685 ENOG4107RSM transcriptional regulator HUT06_RS00690 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT06_RS00700 ENOG4108IND Tetr family transcriptional regulator HUT06_RS00715 ENOG4105GFR rna polymerase sigma factor HUT06_RS00735 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT06_RS00740 ENOG4105KME endoribonuclease L-psp HUT06_RS00815 ENOG41082J7 Rhodanese domain protein HUT06_RS00825 ENOG4105BZU Histidine kinase HUT06_RS00835 ENOG4105CEU Arginine dihydrolase HUT06_RS00870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS00875 ENOG4105BZU Histidine kinase HUT06_RS00890 ENOG4105CKK Glycosyl transferase, family 2 HUT06_RS00900 ENOG4108VJY integral membrane protein HUT06_RS00915 ENOG4107ZXU DSBA oxidoreductase HUT06_RS00930 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT06_RS00940 ENOG4108VC7 Protein of unknown function (DUF2587) HUT06_RS00945 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT06_RS00985 ENOG4105EUB pirin domain protein HUT06_RS01025 ENOG4105NAF rna polymerase sigma factor HUT06_RS01030 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS01065 ENOG4105BZU Histidine kinase HUT06_RS01070 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS01075 ENOG4108UGD Serine Threonine protein kinase HUT06_RS01085 ENOG4105C7W Xanthine dehydrogenase HUT06_RS01090 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT06_RS01095 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT06_RS01105 ENOG4108KPJ rna polymerase sigma factor HUT06_RS01115 ENOG4105CB2 alcohol dehydrogenase HUT06_RS01125 ENOG4105CJ1 ABC, transporter HUT06_RS01135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS01140 ENOG4105BZU Histidine kinase HUT06_RS01155 ENOG4108KPJ rna polymerase sigma factor HUT06_RS01195 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT06_RS01255 ENOG4108M8W Monooxygenase HUT06_RS01345 ENOG4108Z6Z Transcriptional regulator HUT06_RS01370 ENOG4105CPC Aldo Keto reductase HUT06_RS01450 ENOG4105RAK Histidine kinase HUT06_RS01455 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HUT06_RS01485 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HUT06_RS01495 ENOG4108HMN Caspase domain HUT06_RS01510 ENOG4105RAK Histidine kinase HUT06_RS01530 ENOG4108SF5 RNA Polymerase HUT06_RS01560 ENOG4108Z40 Transcriptional regulator HUT06_RS01565 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT06_RS01575 ENOG4106HK8 GPR1 FUN34 yaaH family protein HUT06_RS01580 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT06_RS01585 ENOG4105D74 hydrolase HUT06_RS01590 ENOG4105BZU Histidine kinase HUT06_RS01595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS01615 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT06_RS01620 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT06_RS01630 ENOG41082T9 Membrane HUT06_RS01640 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT06_RS01655 ENOG4105C37 (CBS) domain HUT06_RS01660 ENOG4105C37 (CBS) domain HUT06_RS01670 ENOG4107Q25 Serine Threonine protein kinase HUT06_RS01675 ENOG4105D7V transposase HUT06_RS01700 ENOG4107UBR Extracellular solute-binding protein family 3 HUT06_RS01710 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS01725 ENOG4105DZ6 Band 7 protein HUT06_RS01740 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT06_RS01750 ENOG410834F Transcriptional regulator HUT06_RS01755 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HUT06_RS01760 ENOG4105CPC Aldo Keto reductase HUT06_RS01775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT06_RS01785 ENOG4105QVC MOSC domain-containing protein HUT06_RS01795 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT06_RS01800 ENOG4105D7N magnesium and cobalt transport protein CorA HUT06_RS01810 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT06_RS01845 ENOG4105DQR SNARE associated Golgi HUT06_RS01855 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUT06_RS01880 ENOG4107SCA Formamidase (EC 3.5.1.49) HUT06_RS01885 ENOG4105IW1 AmiS UreI transporter HUT06_RS01895 ENOG4105DWV Homoserine O-trans-acetylase HUT06_RS01905 ENOG410834F Transcriptional regulator HUT06_RS01945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT06_RS01950 ENOG4105KNI merR family transcriptional Regulator HUT06_RS01955 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT06_RS01960 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT06_RS01965 ENOG4105CFG Acts as a chaperone (By similarity) HUT06_RS01980 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS01985 ENOG4105BZU Histidine kinase HUT06_RS02000 ENOG4105EMN RNA polymerase sigma factor HUT06_RS02010 ENOG4105DU6 RNA polymerase HUT06_RS02025 ENOG4105C57 major facilitator superfamily HUT06_RS02030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT06_RS02035 ENOG4105CHU acetyl-coa acetyltransferase HUT06_RS02055 ENOG4105DF6 Fe-S oxidoreductase HUT06_RS02080 ENOG4108HQS Glycine betaine HUT06_RS02090 ENOG4105DHP deoxycytidine triphosphate deaminase HUT06_RS02200 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT06_RS02245 ENOG4105EUZ Beta-lactamase domain protein HUT06_RS02255 ENOG4108MP6 LysR family Transcriptional regulator HUT06_RS02300 ENOG4108KPJ rna polymerase sigma factor HUT06_RS02325 ENOG4105F27 Major Facilitator HUT06_RS02345 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT06_RS02365 ENOG4105K63 Thioredoxin HUT06_RS02370 ENOG410901E Membrane HUT06_RS02375 ENOG4105C8V SAICAR synthetase HUT06_RS02385 ENOG4105CXN decarboxylase HUT06_RS02400 ENOG4105KT7 mgtC SapB transporter HUT06_RS02420 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUT06_RS02435 ENOG41062D9 Histidine kinase HUT06_RS02450 ENOG4108KGH TRANSCRIPTIONal HUT06_RS02475 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT06_RS02530 ENOG4107R37 Glutamate dehydrogenase HUT06_RS02535 ENOG4105C7K acetolactate synthase HUT06_RS02555 ENOG4105MP9 class II Aldolase HUT06_RS02570 ENOG4105FDP GntR family transcriptional regulator HUT06_RS02585 ENOG41085W3 Transposase HUT06_RS02600 ENOG4105E7U AraC family transcriptional regulator HUT06_RS02655 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT06_RS02670 ENOG4105C0Z ABC transporter HUT06_RS02675 ENOG4108IV0 ABC, transporter HUT06_RS02685 ENOG4105E2D ec 3.2.1.52 HUT06_RS02690 ENOG4108JQ6 ABC transporter HUT06_RS02695 ENOG4105C3U ABC transporter HUT06_RS02740 ENOG4105ECP epimerase HUT06_RS02745 ENOG4107SVH Potassium channel protein HUT06_RS02765 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HUT06_RS02775 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT06_RS02780 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT06_RS02785 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT06_RS02790 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT06_RS02795 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT06_RS02800 ENOG4105DXM phenylacetic acid degradation protein HUT06_RS02805 ENOG4108IG5 Transcriptional regulator HUT06_RS02845 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS02850 ENOG4105KK4 UPF0060 membrane protein HUT06_RS02855 ENOG4105VUF Transcriptional regulator HUT06_RS02860 ENOG4105DBE peroxidase HUT06_RS02875 ENOG4105CX8 fg-gap repeat protein HUT06_RS02890 ENOG4105CH2 amidohydrolase HUT06_RS02895 ENOG4107ZT3 family UPF0126 HUT06_RS02915 ENOG4105E6M Sulphatase-modifying factor protein HUT06_RS02920 ENOG4105E2D ec 3.2.1.52 HUT06_RS02940 ENOG4105CBG Sulfatase HUT06_RS02975 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS02980 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS02990 ENOG4107EFR Flavocytochrome c HUT06_RS03035 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS03040 ENOG4105BZU Histidine kinase HUT06_RS03045 ENOG4105EYF MMPL domain protein HUT06_RS03095 ENOG4105ZXU NLP P60 protein HUT06_RS03110 ENOG4107S5I aldo keto reductase HUT06_RS03130 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HUT06_RS03150 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT06_RS03180 ENOG4105CGU Enoyl-CoA hydratase HUT06_RS03185 ENOG4105BZU Histidine kinase HUT06_RS03190 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS03200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS03255 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT06_RS03260 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT06_RS03295 ENOG4105DRR Transcriptional regulator, GntR family HUT06_RS03300 ENOG4108UAU isochorismatase HUT06_RS03320 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS03335 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS03340 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT06_RS03405 ENOG4105D5G Transposase HUT06_RS03420 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT06_RS03440 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT06_RS03445 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT06_RS03450 ENOG4107QRG dna polymerase iii HUT06_RS03465 ENOG4105JVQ RNA Polymerase HUT06_RS03475 ENOG4105KJF protein tyrosine phosphatase HUT06_RS03495 ENOG4105MA4 psp1 domain protein HUT06_RS03500 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT06_RS03540 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS03545 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS03610 ENOG4105D3Q Sugar transferase HUT06_RS03630 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT06_RS03655 ENOG4105CAY ferredoxin--nadp reductase HUT06_RS03690 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT06_RS03720 ENOG4105K56 Transcriptional regulator HUT06_RS03775 ENOG4105DRR Transcriptional regulator, GntR family HUT06_RS03780 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS03785 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS03800 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HUT06_RS03820 ENOG4107RGH Aldehyde dehydrogenase HUT06_RS03830 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HUT06_RS03845 ENOG4105C85 amino acid HUT06_RS03855 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HUT06_RS03860 ENOG4105DND Transcriptional regulator HUT06_RS03865 ENOG4106F60 Histidine kinase HUT06_RS03895 ENOG4105CHR reductase HUT06_RS03900 ENOG4107RSM transcriptional regulator HUT06_RS03930 ENOG4107UBR Extracellular solute-binding protein family 3 HUT06_RS03980 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUT06_RS04005 ENOG4105I8R Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT06_RS04020 ENOG4108IND Tetr family transcriptional regulator HUT06_RS04025 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT06_RS04045 ENOG4107ZQV short-chain dehydrogenase reductase HUT06_RS04080 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT06_RS04085 ENOG4105C2J ABC transporter HUT06_RS04090 ENOG4107R9N ABC transporter HUT06_RS04095 ENOG41062B0 ABC transporter, permease HUT06_RS04100 ENOG4105D9P serine threonine protein kinase HUT06_RS04125 ENOG4105DGI Alkaline phosphatase HUT06_RS04190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS04200 ENOG4106NZI LysR family Transcriptional regulator HUT06_RS04210 ENOG4105JVQ RNA Polymerase HUT06_RS04280 ENOG4105CR4 methylisocitrate lyase HUT06_RS04290 ENOG4105C94 Transporter HUT06_RS04320 ENOG4105ECQ AraC Family Transcriptional Regulator HUT06_RS04335 ENOG4105CGH 5'-nucleotidase HUT06_RS04340 ENOG4105J5T Amp-dependent synthetase and ligase HUT06_RS04345 ENOG4105CC9 acyl-Coa dehydrogenase HUT06_RS04350 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS04360 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS04375 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS04400 ENOG4108HRK Histidine kinase HUT06_RS04405 ENOG4108NEV two component transcriptional regulator, LytTR family HUT06_RS04425 ENOG4107QN1 sodium solute HUT06_RS04440 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT06_RS04455 ENOG4107STW synthase HUT06_RS04475 ENOG4105J5G Transferase hexapeptide repeat containing protein HUT06_RS04480 ENOG4105K64 Glycosyl transferase, family 2 HUT06_RS04495 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS04500 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS04505 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HUT06_RS04510 ENOG4105CHR reductase HUT06_RS04515 ENOG4107HP6 Transcriptional regulator HUT06_RS04545 ENOG4107RSM transcriptional regulator HUT06_RS04565 ENOG4105CPQ Dehydrogenase HUT06_RS04570 ENOG4106JUT Streptomycin 3''-adenylyltransferase HUT06_RS04585 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HUT06_RS04590 ENOG4105D7V transposase HUT06_RS04615 ENOG4108IUE nitrate reductase beta subunit HUT06_RS04635 ENOG4105CJ1 ABC, transporter HUT06_RS04645 ENOG4105ENE Histidine kinase HUT06_RS04650 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS04655 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT06_RS04660 ENOG4105EYF MMPL domain protein HUT06_RS04665 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS04670 ENOG4105BZU Histidine kinase HUT06_RS04680 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS04685 ENOG4107SCA Formamidase (EC 3.5.1.49) HUT06_RS04690 ENOG4105CUB amino acid HUT06_RS04755 ENOG4105C0Z ABC transporter HUT06_RS04760 ENOG4108IV0 ABC, transporter HUT06_RS04805 ENOG41081E8 Alpha beta hydrolase HUT06_RS04825 ENOG4108KC1 acyl-Coa dehydrogenase HUT06_RS04835 ENOG4107EFR Flavocytochrome c HUT06_RS04840 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT06_RS04850 ENOG4107EFR Flavocytochrome c HUT06_RS04860 ENOG4107EFR Flavocytochrome c HUT06_RS04895 ENOG4105CHP RNA polymerase HUT06_RS04900 ENOG4105GRZ Ycii-related protein HUT06_RS04960 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS04975 ENOG4107QNJ CoA-transferase subunit B HUT06_RS04985 ENOG4105CHU acetyl-coa acetyltransferase HUT06_RS04990 ENOG4107RSM transcriptional regulator HUT06_RS05010 ENOG4105CUT histidyl-tRNA synthetase HUT06_RS05050 ENOG4105CIG ABC transporter HUT06_RS05060 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT06_RS05070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS05110 ENOG4105EYF MMPL domain protein HUT06_RS05115 ENOG4105DFA alanine racemase domain protein HUT06_RS05120 ENOG4105BZU Histidine kinase HUT06_RS05130 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS05180 ENOG4107QZM n-acetylglutamate synthase HUT06_RS05185 ENOG4105EYF MMPL domain protein HUT06_RS05190 ENOG4105BZU Histidine kinase HUT06_RS05200 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT06_RS05220 ENOG4105GWZ Roadblock lc7 family protein HUT06_RS05235 ENOG4105C5Q Transcriptional regulator HUT06_RS05240 ENOG4105C0B DNA polymerase III (alpha subunit) HUT06_RS05255 ENOG41062D9 Histidine kinase HUT06_RS05265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS05270 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT06_RS05285 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUT06_RS05290 ENOG4108KXV response regulator HUT06_RS05305 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT06_RS05430 ENOG4108WFR AraC Family Transcriptional Regulator HUT06_RS05435 ENOG4107QVI Methyltransferase, type 11 HUT06_RS05440 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT06_RS05475 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS05480 ENOG4105BZU Histidine kinase HUT06_RS05485 ENOG4105CJ1 ABC, transporter HUT06_RS05520 ENOG4108M15 ABC transporter HUT06_RS05560 ENOG4105PFC Transcriptional regulator HUT06_RS05565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT06_RS05600 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT06_RS05610 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS05630 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS05650 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT06_RS05655 ENOG4105CGH 5'-nucleotidase HUT06_RS05660 ENOG4105CJ3 phosphate transporter HUT06_RS05675 ENOG4106F1P AAA ATPase, central domain protein HUT06_RS05680 ENOG4108Z0R Transferase HUT06_RS05690 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT06_RS05695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS05700 ENOG4105BZU Histidine kinase HUT06_RS05715 ENOG4108YZN class I peptide chain release factor HUT06_RS05720 ENOG4107NHD transcriptional regulator HUT06_RS05755 ENOG4105KHC sulfurtransferase HUT06_RS05795 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT06_RS05830 ENOG4105EC2 ftsk spoIIIe HUT06_RS05905 ENOG4107TB5 TRANSCRIPTIONal HUT06_RS05910 ENOG4108RYC glycosyltransferase HUT06_RS05920 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT06_RS05935 ENOG410602S Transferase HUT06_RS05945 ENOG4105EY8 ABC transporter HUT06_RS06030 ENOG4105F1K Glutamine amidotransferase HUT06_RS06070 ENOG41061H0 Monooxygenase HUT06_RS06105 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT06_RS06115 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT06_RS06125 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT06_RS06145 ENOG4105DJ2 Major Facilitator Superfamily HUT06_RS06150 ENOG41073TP transcriptional regulator HUT06_RS06185 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT06_RS06190 ENOG41067SE Tetr family transcriptional regulator HUT06_RS06195 ENOG4105EYF MMPL domain protein HUT06_RS06230 ENOG4107S5I aldo keto reductase HUT06_RS06245 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT06_RS06270 ENOG4105D5G Transposase HUT06_RS06290 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HUT06_RS06295 ENOG4108VJY integral membrane protein HUT06_RS06305 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS06330 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT06_RS06335 ENOG4105EJ2 Transcriptional regulator HUT06_RS06340 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT06_RS06355 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUT06_RS06365 ENOG4108UVJ appr-1-p processing domain protein HUT06_RS06400 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT06_RS06410 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT06_RS06420 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HUT06_RS06430 ENOG4108IG5 Transcriptional regulator HUT06_RS06450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS06470 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT06_RS06475 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS06500 ENOG4105CHP RNA polymerase HUT06_RS06505 ENOG4108VQT Alpha beta hydrolase fold protein HUT06_RS06510 ENOG4105C8N cysteinyl-tRNA synthetase HUT06_RS06515 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT06_RS06520 ENOG4108KTG Membrane protein, drug metabolite transporter HUT06_RS06525 ENOG4105CHP RNA polymerase HUT06_RS06560 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT06_RS06565 ENOG4108UPT UPF0178 protein HUT06_RS06590 ENOG41062D9 Histidine kinase HUT06_RS06605 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS06620 ENOG4105Y3U Transglycosylase-associated protein HUT06_RS06635 ENOG4107QN1 sodium solute HUT06_RS06670 ENOG4105NTW Transcriptional regulator HUT06_RS06675 ENOG4108SPH protein kinase (EC 2.7.11.1) HUT06_RS06680 ENOG4105DU6 RNA polymerase HUT06_RS06690 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT06_RS06735 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT06_RS06780 ENOG4105CFI type iii restriction protein res subunit HUT06_RS06785 ENOG4105YVS arsR family transcriptional regulator HUT06_RS06805 ENOG4108IG5 Transcriptional regulator HUT06_RS06825 ENOG4105VEQ Cold shock protein HUT06_RS06830 ENOG4108N0W Major Facilitator superfamily HUT06_RS06855 ENOG4107SFI Major Facilitator superfamily HUT06_RS06860 ENOG41081HM 2'-5' rna ligase HUT06_RS06885 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT06_RS06905 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT06_RS06910 ENOG4105E8G Major facilitator Superfamily HUT06_RS06915 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HUT06_RS06925 ENOG4108Q50 Histidine kinase HUT06_RS06935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT06_RS06955 ENOG4105F2C Acetyl-CoA acetyltransferase HUT06_RS06960 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS06975 ENOG4105CT1 (ABC) transporter HUT06_RS07000 ENOG4106NZI LysR family Transcriptional regulator HUT06_RS07085 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS07090 ENOG4107SM8 Adenylate Guanylate cyclase HUT06_RS07095 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT06_RS07115 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS07120 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT06_RS07150 ENOG4105C26 Dehydrogenase HUT06_RS07155 ENOG4105C26 Dehydrogenase HUT06_RS07175 ENOG4105C75 arginyL-tRNA synthetase HUT06_RS07180 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HUT06_RS07220 ENOG4108V1U phospholipid-binding protein HUT06_RS07230 ENOG4105D56 permease protein HUT06_RS07245 ENOG4105EY8 ABC transporter HUT06_RS07255 ENOG4105CBD Diacylglycerol kinase HUT06_RS07260 ENOG41073R8 VanW family HUT06_RS07290 ENOG4105E2K Glycosyl transferase (Group 1 HUT06_RS07295 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT06_RS07320 ENOG4105C5H ABC transporter HUT06_RS07330 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT06_RS07335 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HUT06_RS07355 ENOG4105C2X Arabinose 5-phosphate isomerase HUT06_RS07365 ENOG4105EMN RNA polymerase sigma factor HUT06_RS07375 ENOG4108Q50 Histidine kinase HUT06_RS07405 ENOG4107RAN Peptidase, M16 HUT06_RS07410 ENOG4105WN5 stage II sporulation protein HUT06_RS07455 ENOG4106F1P AAA ATPase, central domain protein HUT06_RS07460 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HUT06_RS07470 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT06_RS07485 ENOG4105C7B Threonine dehydratase HUT06_RS07490 ENOG4105CHP RNA polymerase HUT06_RS07495 ENOG4105GRZ Ycii-related protein HUT06_RS07525 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT06_RS07530 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT06_RS07540 ENOG4105EQN UPF0261 protein HUT06_RS07550 ENOG4105YKW HUT06_RS07555 ENOG4105K5B UPF0225 protein HUT06_RS07570 ENOG4105CHP RNA polymerase HUT06_RS07585 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT06_RS07590 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT06_RS07595 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUT06_RS07650 ENOG4108UCS ABC, transporter HUT06_RS07660 ENOG4105D7V transposase HUT06_RS07665 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS07670 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS07675 ENOG4108YIQ Alpha beta hydrolase HUT06_RS07680 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT06_RS07690 ENOG4105DBV ornithine carbamoyltransferase HUT06_RS07700 ENOG4105D5Q Arginine ornithine antiporter HUT06_RS07705 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT06_RS07710 ENOG4108KPJ rna polymerase sigma factor HUT06_RS07715 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS07725 ENOG4108Q9V regulatoR HUT06_RS07750 ENOG4108UZE carboxy-peptidase HUT06_RS07755 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT06_RS07765 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT06_RS07770 ENOG4105EYF MMPL domain protein HUT06_RS07780 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HUT06_RS07785 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT06_RS07790 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT06_RS07800 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT06_RS07805 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUT06_RS07830 ENOG4105KME endoribonuclease L-psp HUT06_RS07840 ENOG4106F60 Histidine kinase HUT06_RS07860 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT06_RS07865 ENOG4105CJ1 ABC, transporter HUT06_RS07895 ENOG4105CE4 GlcNAc 6-P deacetylase HUT06_RS07900 ENOG4105E98 transcriptional regulator DeoR family HUT06_RS07905 ENOG4105C8N cysteinyl-tRNA synthetase HUT06_RS07920 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT06_RS07930 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS07945 ENOG4108UAU isochorismatase HUT06_RS07965 ENOG4108PJD permease HUT06_RS07970 ENOG4105C3M thioredoxin reductase HUT06_RS07990 ENOG4105K63 Thioredoxin HUT06_RS07995 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT06_RS08005 ENOG4105DUM transcriptional regulator, lysR family HUT06_RS08015 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT06_RS08020 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS08025 ENOG4105CPC Aldo Keto reductase HUT06_RS08035 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HUT06_RS08045 ENOG4105DPX Hydrogenase, large subunit HUT06_RS08090 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT06_RS08095 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HUT06_RS08130 ENOG4107SCK Monooxygenase HUT06_RS08165 ENOG4105VNT transposase (IS4 family) protein HUT06_RS08170 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT06_RS08185 ENOG4107RDJ Sulfotransferase HUT06_RS08215 ENOG4107RCI amp-dependent synthetase and ligase HUT06_RS08290 ENOG4105CT1 (ABC) transporter HUT06_RS08300 ENOG4105D9P serine threonine protein kinase HUT06_RS08315 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT06_RS08330 ENOG4106F1P AAA ATPase, central domain protein HUT06_RS08340 ENOG4106NZI LysR family Transcriptional regulator HUT06_RS08350 ENOG4105EV4 Multidrug resistance protein mdtH HUT06_RS08355 ENOG4108J4B Beta-lactamase HUT06_RS08360 ENOG4105D7N magnesium and cobalt transport protein CorA HUT06_RS08365 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS08395 ENOG4105CKK Glycosyl transferase, family 2 HUT06_RS08410 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT06_RS08415 ENOG4105F8V Hydrolase, tatD family HUT06_RS08425 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT06_RS08435 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT06_RS08450 ENOG4105C5H ABC transporter HUT06_RS08455 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT06_RS08460 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT06_RS08465 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT06_RS08470 ENOG4108RZE Tetr family transcriptional regulator HUT06_RS08485 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT06_RS08490 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT06_RS08495 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT06_RS08500 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT06_RS08505 ENOG4105D3Q Sugar transferase HUT06_RS08510 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo HUT06_RS08525 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT06_RS08535 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUT06_RS08540 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUT06_RS08580 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HUT06_RS08595 ENOG4107TSN permease HUT06_RS08600 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) HUT06_RS08640 ENOG4105BZ4 penicillin-binding protein HUT06_RS08660 ENOG4105GR3 Histidine kinase HUT06_RS08680 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT06_RS08710 ENOG4105CEP NADH dehydrogenase HUT06_RS08730 ENOG4105CHU acetyl-coa acetyltransferase HUT06_RS08745 ENOG4105EYF MMPL domain protein HUT06_RS08770 ENOG4105EET magnesium chelatase HUT06_RS08780 ENOG4105DKQ ROK family HUT06_RS08785 ENOG4105C7B Threonine dehydratase HUT06_RS08795 ENOG4105CD8 aminopeptidase N HUT06_RS08800 ENOG4105VQU rdd domain containing protein HUT06_RS08810 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT06_RS08820 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT06_RS08830 ENOG4105T1M mycothiol conjugate amidase mca HUT06_RS08850 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT06_RS08855 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT06_RS08860 ENOG4105C7Z Conserved Protein HUT06_RS08875 ENOG4105C57 major facilitator superfamily HUT06_RS08885 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT06_RS08890 ENOG4108IAB Phoh family HUT06_RS08900 ENOG4105C9Q fumarate hydratase class II HUT06_RS08910 ENOG4107GFK fumarate HUT06_RS08925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT06_RS08970 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT06_RS08975 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT06_RS08990 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT06_RS09005 ENOG4105C3G gtp-binding protein HUT06_RS09055 ENOG4105M6F mutator MutT protein HUT06_RS09060 ENOG4105ZXU NLP P60 protein HUT06_RS09065 ENOG4105CI3 gtp-binding protein typa HUT06_RS09080 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT06_RS09090 ENOG4105D9P serine threonine protein kinase HUT06_RS09190 ENOG4107TB5 TRANSCRIPTIONal HUT06_RS09205 ENOG4105CDV Ompa motb domain protein HUT06_RS09225 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT06_RS09240 ENOG4105F04 LysR family Transcriptional regulator HUT06_RS09245 ENOG41066UZ arginase EC 3.5.3.1 HUT06_RS09250 ENOG4105E33 succinate dehydrogenase HUT06_RS09265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUT06_RS09270 ENOG4105BZ1 (ABC) transporter HUT06_RS09275 ENOG4105BZ1 (ABC) transporter HUT06_RS09290 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT06_RS09310 ENOG4108KGH TRANSCRIPTIONal HUT06_RS09315 ENOG4105C8Y Acetylornithine aminotransferase HUT06_RS09320 ENOG4105J0Q Transcriptional regulator HUT06_RS09325 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HUT06_RS09345 ENOG4105M4P Tetr family transcriptional regulator HUT06_RS09355 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT06_RS09375 ENOG4105BZU Histidine kinase HUT06_RS09380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS09420 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS09485 ENOG4105C8N cysteinyl-tRNA synthetase HUT06_RS09490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT06_RS09500 ENOG4105CGU Enoyl-CoA hydratase HUT06_RS09525 ENOG4108Z4U Ferredoxin HUT06_RS09555 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT06_RS09560 ENOG4108Z4X TRANSCRIPTIONal HUT06_RS09565 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS09580 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT06_RS09590 ENOG4106F60 Histidine kinase HUT06_RS09595 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT06_RS09600 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT06_RS09610 ENOG4105ECQ AraC Family Transcriptional Regulator HUT06_RS09630 ENOG4105MHT Transcriptional regulator, ARSR family HUT06_RS09640 ENOG4105SCY DNAK suppressor HUT06_RS09705 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT06_RS09745 ENOG4105JNK Glycosyl transferase (Group 1 HUT06_RS09750 ENOG4108Z5V transcriptional regulator, merr family HUT06_RS09760 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HUT06_RS09775 ENOG4105D7V transposase HUT06_RS09780 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT06_RS09785 ENOG4108URH decarboxylase HUT06_RS09840 ENOG4105DIA mandelate racemase muconate lactonizing HUT06_RS09855 ENOG4105C0H protease HUT06_RS09860 ENOG4108X07 Tetr family transcriptional regulator HUT06_RS09865 ENOG4105CIG ABC transporter HUT06_RS09870 ENOG4105DIM ABC transporter HUT06_RS09875 ENOG4108URH decarboxylase HUT06_RS09885 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HUT06_RS09915 ENOG4105D38 putrescine abc transporter HUT06_RS09920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS09930 ENOG4105ECY inositol monophosphatase HUT06_RS09935 ENOG410667J hydrolase HUT06_RS09945 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS09960 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HUT06_RS09975 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUT06_RS09980 ENOG4105C26 Dehydrogenase HUT06_RS10005 ENOG4108R3E Dna-3-methyladenine glycosylase i HUT06_RS10015 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS10020 ENOG4108UKI Enoyl-CoA hydratase HUT06_RS10030 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT06_RS10040 ENOG4107ZBN O-methyltransferase HUT06_RS10045 ENOG4105DU6 RNA polymerase HUT06_RS10060 ENOG4105C0H protease HUT06_RS10065 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT06_RS10085 ENOG4105CJW magnesium transporter HUT06_RS10120 ENOG4105DB7 PHP domain protein HUT06_RS10145 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT06_RS10150 ENOG4105CQB FAD linked oxidase domain protein HUT06_RS10170 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT06_RS10180 ENOG4105C1J atp-dependent rna helicase HUT06_RS10210 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT06_RS10215 ENOG4105DQE DNA ligase HUT06_RS10220 ENOG4105DQE DNA ligase HUT06_RS10225 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT06_RS10235 ENOG4107R13 MMPL domain protein HUT06_RS10240 ENOG4107R13 MMPL domain protein HUT06_RS10250 ENOG4108REK sugar kinase HUT06_RS10300 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HUT06_RS10310 ENOG4105C4R Atp-dependent dna helicase HUT06_RS10315 ENOG4105C4R Atp-dependent dna helicase HUT06_RS10320 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT06_RS10330 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS10345 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT06_RS10360 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT06_RS10375 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT06_RS10395 ENOG4105C29 acyl-CoA thioesterase HUT06_RS10405 ENOG4105BZU Histidine kinase HUT06_RS10410 ENOG4105CIR epoxide hydrolase HUT06_RS10420 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT06_RS10485 ENOG4105DJZ UPF0182 protein HUT06_RS10500 ENOG41063PX domain protein HUT06_RS10510 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS10525 ENOG4105C26 Dehydrogenase HUT06_RS10555 ENOG4107RCI amp-dependent synthetase and ligase HUT06_RS10570 ENOG4108W6C Dehydrogenase HUT06_RS10580 ENOG41060BG Tetr family transcriptional regulator HUT06_RS10585 ENOG4105EBR Carboxylesterase HUT06_RS10590 ENOG4105D5U fad dependent oxidoreductase HUT06_RS10600 ENOG4107TK4 histidinol-phosphate phosphatase HUT06_RS10620 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT06_RS10640 ENOG4108RAV Conserved protein HUT06_RS10650 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT06_RS10655 ENOG4105EMN RNA polymerase sigma factor HUT06_RS10660 ENOG4105WMN AntiSigma factor HUT06_RS10665 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUT06_RS10670 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT06_RS10740 ENOG4105QE3 oxidoreductase HUT06_RS10745 ENOG4106F60 Histidine kinase HUT06_RS10750 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT06_RS10770 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS10830 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT06_RS10915 ENOG4105JSC dimethylmenaquinone methyltransferase HUT06_RS10940 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT06_RS10945 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT06_RS10955 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT06_RS10970 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT06_RS10975 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT06_RS10985 ENOG4105FDP GntR family transcriptional regulator HUT06_RS11005 ENOG4105CBD Diacylglycerol kinase HUT06_RS11020 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT06_RS11055 ENOG4107YCY Transcriptional regulator HUT06_RS11070 ENOG4105EG2 ABC transporter, permease HUT06_RS11080 ENOG4105EQX glucarate dehydratase HUT06_RS11090 ENOG4108VEQ Superoxide dismutase HUT06_RS11100 ENOG4105CZV ABC transporter HUT06_RS11115 ENOG4105BZU Histidine kinase HUT06_RS11120 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS11165 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT06_RS11170 ENOG4105C6K Malic enzyme HUT06_RS11175 ENOG4107R0W ABC transporter HUT06_RS11180 ENOG4105E5Q amino acid AbC transporter HUT06_RS11185 ENOG4105CDA abc transporter atp-binding protein HUT06_RS11215 ENOG4105CB2 alcohol dehydrogenase HUT06_RS11235 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT06_RS11245 ENOG4105CHF Glutathione S-transferase HUT06_RS11260 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT06_RS11265 ENOG4108UKI Enoyl-CoA hydratase HUT06_RS11280 ENOG4105GWZ Roadblock lc7 family protein HUT06_RS11300 ENOG4105GWZ Roadblock lc7 family protein HUT06_RS11315 ENOG4105E2R ROK family HUT06_RS11320 ENOG4105C2J ABC transporter HUT06_RS11325 ENOG4105CNN ABC, transporter HUT06_RS11330 ENOG4105DFW ABC transporter HUT06_RS11385 ENOG4107QPD alcohol dehydrogenase HUT06_RS11405 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HUT06_RS11410 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT06_RS11415 ENOG4106A3M Cytochrome p-450 HUT06_RS11420 ENOG4106A3M Cytochrome p-450 HUT06_RS11440 ENOG4105F2C Acetyl-CoA acetyltransferase HUT06_RS11445 ENOG4106A3M Cytochrome p-450 HUT06_RS11460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT06_RS11465 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT06_RS11470 ENOG4106A3M Cytochrome p-450 HUT06_RS11475 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS11505 ENOG4105VT2 5-hydroxyisourate hydrolase HUT06_RS11525 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT06_RS11530 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT06_RS11555 ENOG4108SGK Tetr family transcriptional regulator HUT06_RS11560 ENOG4105J5T Amp-dependent synthetase and ligase HUT06_RS11565 ENOG4108RK3 acyl-Coa dehydrogenase HUT06_RS11570 ENOG4105X7H acyl-CoA dehydrogenase HUT06_RS11575 ENOG4105CVK Glutamate decarboxylase HUT06_RS11600 ENOG4105D1K glutamate--cysteine ligase HUT06_RS11605 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT06_RS11615 ENOG41067HS methyltransferase HUT06_RS11645 ENOG4105C84 Histidine ammonia-lyase HUT06_RS11650 ENOG4108IJ8 ABC transporter HUT06_RS11655 ENOG4105E90 ABC transporter HUT06_RS11660 ENOG4105E90 ABC transporter HUT06_RS11690 ENOG4105CIR epoxide hydrolase HUT06_RS11715 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS11740 ENOG4105C84 Histidine ammonia-lyase HUT06_RS11745 ENOG4105CGP Urocanate hydratase HUT06_RS11795 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT06_RS11825 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT06_RS11835 ENOG41073TP transcriptional regulator HUT06_RS11840 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HUT06_RS11850 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT06_RS11855 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUT06_RS11865 ENOG4105VZ8 Transcriptional regulator HUT06_RS11880 ENOG4105ENE Histidine kinase HUT06_RS11885 ENOG4107XWB Zinc finger, swim domain protein HUT06_RS11890 ENOG4105C0D helicase HUT06_RS11900 ENOG4105KVH Transcriptional regulator HUT06_RS11910 ENOG4105EMU Dehydrogenase HUT06_RS11940 ENOG4105C10 Electron transfer flavoprotein HUT06_RS11975 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT06_RS11990 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT06_RS11995 ENOG4105BZU Histidine kinase HUT06_RS12010 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT06_RS12015 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT06_RS12020 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT06_RS12045 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT06_RS12060 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT06_RS12090 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT06_RS12095 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT06_RS12100 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT06_RS12145 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS12180 ENOG4105EYF MMPL domain protein HUT06_RS12195 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT06_RS12205 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT06_RS12215 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS12220 ENOG4105D65 subunit l HUT06_RS12225 ENOG4105C8S subunit m HUT06_RS12230 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS12240 ENOG4105CDA abc transporter atp-binding protein HUT06_RS12245 ENOG4105EAD ABC transporter HUT06_RS12255 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HUT06_RS12260 ENOG4107NQ8 LysR family Transcriptional regulator HUT06_RS12265 ENOG4106KE4 Dehydrogenase HUT06_RS12275 ENOG4105W1Y Transcriptional regulator HUT06_RS12280 ENOG41069M3 Transcriptional regulator HUT06_RS12285 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT06_RS12290 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT06_RS12300 ENOG4105K70 DNA-binding protein HUT06_RS12320 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT06_RS12325 ENOG4105CPF Cell wall formation (By similarity) HUT06_RS12395 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT06_RS12435 ENOG4105DWF phosphomethylpyrimidine kinase HUT06_RS12440 ENOG4105VB9 50S ribosomal protein l28 HUT06_RS12445 ENOG4105DP4 dak2 domain fusion protein ylov HUT06_RS12465 ENOG4106H78 methyltransferase HUT06_RS12475 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT06_RS12485 ENOG41084BZ 50S ribosomal protein L32 HUT06_RS12490 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT06_RS12495 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT06_RS12500 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUT06_RS12510 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUT06_RS12520 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HUT06_RS12545 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT06_RS12555 ENOG4105K5M 30s ribosomal protein S16 HUT06_RS12560 ENOG41082KU UPF0109 protein HUT06_RS12565 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT06_RS12580 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT06_RS12585 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT06_RS12595 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT06_RS12615 ENOG41080R2 UPF0102 protein HUT06_RS12620 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT06_RS12630 ENOG4105CE9 30S ribosomal protein S2 HUT06_RS12635 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT06_RS12640 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT06_RS12645 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT06_RS12650 ENOG4105KNE Phosphatidate cytidylyltransferase HUT06_RS12660 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT06_RS12680 ENOG4105CIG ABC transporter HUT06_RS12700 ENOG4105C26 Dehydrogenase HUT06_RS12705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS12715 ENOG4105F38 ABC transporter, permease HUT06_RS12720 ENOG4105D38 putrescine abc transporter HUT06_RS12740 ENOG4107UBR Extracellular solute-binding protein family 3 HUT06_RS12765 ENOG4107Q25 Serine Threonine protein kinase HUT06_RS12780 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT06_RS12790 ENOG4108YIQ Alpha beta hydrolase HUT06_RS12800 ENOG4105C8Y Acetylornithine aminotransferase HUT06_RS12805 ENOG4105C26 Dehydrogenase HUT06_RS12840 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT06_RS12845 ENOG4106JDR secreted HUT06_RS12850 ENOG4106JDR secreted HUT06_RS12910 ENOG4105CSH Transporter HUT06_RS12920 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HUT06_RS12940 ENOG4105EB3 Histidine kinase HUT06_RS12960 ENOG4105K59 histidine triad (HIT) protein HUT06_RS13000 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT06_RS13010 ENOG4105CRK lysyL-tRNA synthetase HUT06_RS13025 ENOG4108RZE Tetr family transcriptional regulator HUT06_RS13030 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT06_RS13075 ENOG4105DFW ABC transporter HUT06_RS13080 ENOG4105C2J ABC transporter HUT06_RS13085 ENOG4108HWW ABC transporter HUT06_RS13090 ENOG4105C2J ABC transporter HUT06_RS13095 ENOG4105E2R ROK family HUT06_RS13135 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT06_RS13150 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT06_RS13160 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT06_RS13165 ENOG4105SFS phosphoesterase RecJ domain protein HUT06_RS13170 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT06_RS13185 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT06_RS13190 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT06_RS13195 ENOG4105C1V Peptidase, M16 HUT06_RS13200 ENOG41082T9 Membrane HUT06_RS13205 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT06_RS13210 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT06_RS13220 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HUT06_RS13235 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT06_RS13275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT06_RS13300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT06_RS13305 ENOG4105CN5 Metallo-Beta-Lactamase HUT06_RS13320 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT06_RS13335 ENOG4105CEV competence damage-inducible protein HUT06_RS13340 ENOG4105WBV Transcriptional regulator HUT06_RS13355 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT06_RS13390 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT06_RS13395 ENOG4107QRT dEAD DEAH box helicase HUT06_RS13415 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT06_RS13420 ENOG4105KC9 Modulates RecA activity (By similarity) HUT06_RS13425 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HUT06_RS13430 ENOG4108MXZ Esterase HUT06_RS13435 ENOG4105DRP amino acid AbC transporter HUT06_RS13440 ENOG4108Q1T ABC transporter HUT06_RS13445 ENOG4107UBR Extracellular solute-binding protein family 3 HUT06_RS13450 ENOG4105CDA abc transporter atp-binding protein HUT06_RS13455 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT06_RS13470 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT06_RS13475 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT06_RS13480 ENOG4105BZU Histidine kinase HUT06_RS13510 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT06_RS13515 ENOG4105CQB FAD linked oxidase domain protein HUT06_RS13520 ENOG4105CQB FAD linked oxidase domain protein HUT06_RS13525 ENOG4107R9S Malate synthase HUT06_RS13530 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT06_RS13535 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT06_RS13540 ENOG4105EPR degv family HUT06_RS13565 ENOG4105DUM transcriptional regulator, lysR family HUT06_RS13575 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HUT06_RS13580 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT06_RS13585 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT06_RS13620 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT06_RS13625 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT06_RS13645 ENOG4107YU2 histidine triad (hIT) protein HUT06_RS13655 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT06_RS13670 ENOG4105EYF MMPL domain protein HUT06_RS13680 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT06_RS13695 ENOG4106V2I dimethylaminohydrolase HUT06_RS13700 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT06_RS13710 ENOG4105D4Y metalloprotease HUT06_RS13715 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT06_RS13720 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT06_RS13725 ENOG4108Z9K Osmotically inducible protein HUT06_RS13745 ENOG4105DIK (ABC) transporter HUT06_RS13750 ENOG4105DSE periplasmic solute binding protein HUT06_RS13770 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT06_RS13785 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT06_RS13800 ENOG4105BZP glycoside hydrolase 15-related HUT06_RS13805 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT06_RS13815 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT06_RS13820 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HUT06_RS13825 ENOG4106UW1 Major Facilitator superfamily HUT06_RS13835 ENOG4108KPJ rna polymerase sigma factor HUT06_RS13840 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT06_RS13845 ENOG4105VUF Transcriptional regulator HUT06_RS13870 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUT06_RS13875 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT06_RS13880 ENOG41082VC UPF0145 protein HUT06_RS13890 ENOG4105DBE peroxidase HUT06_RS13930 ENOG4105DAX Pfam:DUF2983 HUT06_RS13980 ENOG4107RHI Cytosine-specific methyltransferase HUT06_RS14060 ENOG4105CDU Replicative dna helicase HUT06_RS14095 ENOG4105D65 subunit l HUT06_RS14100 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT06_RS14105 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT06_RS14120 ENOG4105KJM monovalent cation h antiporter subunit g HUT06_RS14130 ENOG4105ENE Histidine kinase HUT06_RS14135 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS14160 ENOG4105DQ5 transport system permease protein HUT06_RS14165 ENOG4105TVJ transport system, permease HUT06_RS14170 ENOG4105E0A ABC, transporter HUT06_RS14195 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS14200 ENOG4105C0Z ABC transporter HUT06_RS14205 ENOG4108IV0 ABC, transporter HUT06_RS14245 ENOG4107UWP Major facilitator superfamily MFS_1 HUT06_RS14265 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT06_RS14285 ENOG4105CUB amino acid HUT06_RS14290 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT06_RS14305 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS14315 ENOG4105VPX protein, conserved in bacteria HUT06_RS14320 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT06_RS14335 ENOG4105BZW Glycerate kinase HUT06_RS14340 ENOG4105C7N Xanthine uracil vitamin C permease HUT06_RS14365 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein HUT06_RS14370 ENOG4105BZU Histidine kinase HUT06_RS14375 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS14380 ENOG4105FBW Monooxygenase HUT06_RS14395 ENOG4108KXV response regulator HUT06_RS14400 ENOG41065SU Two-component system sensor kinase HUT06_RS14445 ENOG4105CKD glutathione-regulated potassium-efflux system protein HUT06_RS14460 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT06_RS14465 ENOG4105C57 major facilitator superfamily HUT06_RS14490 ENOG4105EC2 ftsk spoIIIe HUT06_RS14550 ENOG4105C4K Nad synthetase HUT06_RS14570 ENOG4105EAB amino acid AbC transporter HUT06_RS14575 ENOG4105EAD ABC transporter HUT06_RS14580 ENOG4105CDA abc transporter atp-binding protein HUT06_RS14585 ENOG4105C5F glutamine synthetase HUT06_RS14590 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT06_RS14605 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT06_RS14640 ENOG4105C5F glutamine synthetase HUT06_RS14655 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT06_RS14665 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT06_RS14670 ENOG4105EC3 peptidase S51, dipeptidase E HUT06_RS14675 ENOG4105ECP epimerase HUT06_RS14690 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT06_RS14695 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HUT06_RS14700 ENOG4108YZT Adenosylcobinamide kinase HUT06_RS14715 ENOG4105CPC Aldo Keto reductase HUT06_RS14735 ENOG4105D0M Protease HtpX homolog HUT06_RS14745 ENOG4105D0M Protease HtpX homolog HUT06_RS14755 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT06_RS14765 ENOG4107T4Z adenosine kinase HUT06_RS14770 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HUT06_RS14775 ENOG4107QI6 Cysteine desulfurase HUT06_RS14780 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT06_RS14785 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT06_RS14790 ENOG4105MCD Part of cytochrome c oxidase, its function is HUT06_RS14795 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT06_RS14800 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HUT06_RS14815 ENOG4107SN7 NLP P60 protein HUT06_RS14840 ENOG4107S1N anthranilate phosphoribosyltransferase HUT06_RS14850 ENOG4105CCU oxidase (Subunit III) HUT06_RS14855 ENOG4107UDY cytochrome C HUT06_RS14860 ENOG4107EUI c reductase, iron-sulfur HUT06_RS14865 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT06_RS14870 ENOG4105JNK Glycosyl transferase (Group 1 HUT06_RS14915 ENOG4108IQE Amp-dependent synthetase and ligase HUT06_RS14920 ENOG4106N3A copper homeostasis protein cutc HUT06_RS14935 ENOG4105DKQ ROK family HUT06_RS14950 ENOG4105E9Q Acyl-transferase HUT06_RS14960 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS14970 ENOG4105E18 UPF0276 protein HUT06_RS14975 ENOG4105E18 UPF0276 protein HUT06_RS14985 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HUT06_RS14995 ENOG4108RNG Permease of the drug metabolite transporter HUT06_RS15000 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase HUT06_RS15010 ENOG4108HRK Histidine kinase HUT06_RS15015 ENOG4108NEV two component transcriptional regulator, LytTR family HUT06_RS15030 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT06_RS15040 ENOG4107Y9U Membrane HUT06_RS15045 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT06_RS15065 ENOG4105KYH transcriptional regulatory protein HUT06_RS15070 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT06_RS15140 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F HUT06_RS15170 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT06_RS15175 ENOG4105CXT aspartate transcarbamylase HUT06_RS15180 ENOG4105CD3 dihydroorotase HUT06_RS15185 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT06_RS15195 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HUT06_RS15200 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HUT06_RS15205 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HUT06_RS15215 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUT06_RS15220 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT06_RS15230 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT06_RS15240 ENOG4107RSZ Primosomal protein n' HUT06_RS15250 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT06_RS15255 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT06_RS15265 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT06_RS15270 ENOG4105DJV ribulose-phosphate 3-epimerase HUT06_RS15275 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HUT06_RS15280 ENOG4108MIB HUT06_RS15355 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT06_RS15360 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT06_RS15365 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT06_RS15405 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HUT06_RS15410 ENOG41084WP Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUT06_RS15435 ENOG4107REC cytoplasmic protein HUT06_RS15440 ENOG4107R1Q Membrane protein FdrA HUT06_RS15450 ENOG4105G9B Transcriptional regulator HUT06_RS15455 ENOG4105C2W permease HUT06_RS15510 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT06_RS15515 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HUT06_RS15535 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS15540 ENOG4107Z3H Transcriptional regulator, TetR family HUT06_RS15550 ENOG4105CJ1 ABC, transporter HUT06_RS15560 ENOG4105BZU Histidine kinase HUT06_RS15565 ENOG4108S01 response regulator HUT06_RS15585 ENOG4105CWN amidohydrolase HUT06_RS15600 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HUT06_RS15605 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS15640 ENOG4105CHR reductase HUT06_RS15655 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT06_RS15660 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT06_RS15665 ENOG4105D49 3-dehydroquinate synthase HUT06_RS15670 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT06_RS15675 ENOG4105J7D transcriptional regulator HUT06_RS15685 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS15690 ENOG4105DYW oxidoreductase HUT06_RS15700 ENOG4105DC7 peptidase M24 HUT06_RS15705 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT06_RS15710 ENOG410803B Involved in the transcription termination process (By similarity) HUT06_RS15740 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT06_RS15745 ENOG4108V6E Cell division protein mraZ HUT06_RS15750 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT06_RS15760 ENOG4105CJN penicillin-binding protein HUT06_RS15765 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT06_RS15775 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT06_RS15780 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT06_RS15790 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT06_RS15795 ENOG4105DFU Cell wall formation (By similarity) HUT06_RS15805 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT06_RS15810 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUT06_RS15815 ENOG4105DFA alanine racemase domain protein HUT06_RS15820 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT06_RS15830 ENOG4107VQS DivIVA family HUT06_RS15845 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT06_RS15855 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT06_RS15880 ENOG4105C0B DNA polymerase III (alpha subunit) HUT06_RS15905 ENOG4108Z66 YbaK ebsC protein HUT06_RS15910 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT06_RS15915 ENOG4107TIF Phenazine biosynthesis protein, PhzF family HUT06_RS15920 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT06_RS15925 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT06_RS15930 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT06_RS15940 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT06_RS15945 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT06_RS15950 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT06_RS15960 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS15965 ENOG4105X7H acyl-CoA dehydrogenase HUT06_RS16000 ENOG4105BZ1 (ABC) transporter HUT06_RS16005 ENOG4105BZ1 (ABC) transporter HUT06_RS16015 ENOG4105VEQ Cold shock protein HUT06_RS16020 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT06_RS16030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS16040 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT06_RS16045 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT06_RS16050 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT06_RS16070 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT06_RS16090 ENOG4105CBC glutamate synthase HUT06_RS16125 ENOG4107R7Y intracellular protease Pfpi family HUT06_RS16145 ENOG4105CP9 extracellular ligand-binding receptor HUT06_RS16150 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS16155 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT06_RS16160 ENOG4105C0Z ABC transporter HUT06_RS16165 ENOG4108IV0 ABC, transporter HUT06_RS16175 ENOG4105KA0 thioesterase Superfamily protein HUT06_RS16205 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT06_RS16225 ENOG4105CNF WD-40 repeat protein HUT06_RS16250 ENOG4108ZGX Histidine kinase HUT06_RS16255 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUT06_RS16290 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS16295 ENOG4105BZU Histidine kinase HUT06_RS16335 ENOG4105CHR reductase HUT06_RS16355 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT06_RS16410 ENOG4105EV8 ectoine hydroxylase HUT06_RS16415 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HUT06_RS16420 ENOG4108JPW Aminotransferase HUT06_RS16425 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HUT06_RS16440 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT06_RS16465 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUT06_RS16470 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT06_RS16480 ENOG4105KHN chorismate mutase HUT06_RS16490 ENOG4105CAT Cytidine monophosphate kinase HUT06_RS16495 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT06_RS16535 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT06_RS16545 ENOG4108Z4X TRANSCRIPTIONal HUT06_RS16560 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT06_RS16575 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUT06_RS16585 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT06_RS16680 ENOG4107R33 ppx gppa phosphatase HUT06_RS16685 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT06_RS16690 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT06_RS16695 ENOG4108MGI Transcriptional regulator HUT06_RS16700 ENOG4105C57 major facilitator superfamily HUT06_RS16715 ENOG4105DDN Pentapeptide repeat-containing protein HUT06_RS16720 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT06_RS16740 ENOG4105DIA mandelate racemase muconate lactonizing HUT06_RS16745 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HUT06_RS16750 ENOG4106NZI LysR family Transcriptional regulator HUT06_RS16765 ENOG4105ETX regulatoR HUT06_RS16785 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT06_RS16810 ENOG4107T5V SNARE associated Golgi HUT06_RS16815 ENOG4105BZU Histidine kinase HUT06_RS16820 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HUT06_RS16825 ENOG4105E2A Dehydrogenase HUT06_RS16870 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT06_RS16890 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS16950 ENOG4105NAF rna polymerase sigma factor HUT06_RS16960 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS16965 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT06_RS16975 ENOG4107QX3 carboxylase HUT06_RS16995 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS17010 ENOG4105E0A ABC, transporter HUT06_RS17015 ENOG4105EHG Permease protein HUT06_RS17025 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT06_RS17070 ENOG4105E90 ABC transporter HUT06_RS17075 ENOG4108IJ8 ABC transporter HUT06_RS17090 ENOG4105K70 DNA-binding protein HUT06_RS17095 ENOG4105CYC Transferase HUT06_RS17100 ENOG4105C6Z Gluconate HUT06_RS17130 ENOG4105CHR reductase HUT06_RS17165 ENOG4105CIG ABC transporter HUT06_RS17175 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS17235 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS17245 ENOG4105DBV ornithine carbamoyltransferase HUT06_RS17265 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT06_RS17275 ENOG4105VPX protein, conserved in bacteria HUT06_RS17290 ENOG4108VCT Sulfite exporter TauE/SafE HUT06_RS17310 ENOG4105D38 putrescine abc transporter HUT06_RS17315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS17320 ENOG4105C7K acetolactate synthase HUT06_RS17335 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS17345 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HUT06_RS17390 ENOG4105H3G oxidoreductase HUT06_RS17395 ENOG41082BM Transcriptional regulator, arsr family HUT06_RS17425 ENOG4107SGM protein serine threonine phosphatase HUT06_RS17430 ENOG4105CH6 catalase HUT06_RS17445 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT06_RS17450 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HUT06_RS17465 ENOG4105CIF Ornithine Cyclodeaminase HUT06_RS17480 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS17490 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein HUT06_RS17505 ENOG4105C0W non-ribosomal peptide synthetase HUT06_RS17530 ENOG4106A3M Cytochrome p-450 HUT06_RS17560 ENOG4106A3M Cytochrome p-450 HUT06_RS17575 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT06_RS17595 ENOG4108S01 response regulator HUT06_RS17605 ENOG4105CJ1 ABC, transporter HUT06_RS17630 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid HUT06_RS17635 ENOG4105EQK -acetyltransferase HUT06_RS17640 ENOG4107RSM transcriptional regulator HUT06_RS17655 ENOG4105EMN RNA polymerase sigma factor HUT06_RS17660 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HUT06_RS17690 ENOG4107QM5 aconitate hydratase HUT06_RS17700 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS17705 ENOG4107258 Transcriptional regulator HUT06_RS17715 ENOG4105CSH Transporter HUT06_RS17720 ENOG4105C26 Dehydrogenase HUT06_RS17730 ENOG4108KXM LysR family Transcriptional regulator HUT06_RS17810 ENOG4107SJB teichoic acid biosynthesis HUT06_RS17815 ENOG4105CG5 Glycosyl transferase (Group 1 HUT06_RS17820 ENOG4105CC9 acyl-Coa dehydrogenase HUT06_RS17825 ENOG4105CHR reductase HUT06_RS17830 ENOG4108RZE Tetr family transcriptional regulator HUT06_RS17835 ENOG4105F2C Acetyl-CoA acetyltransferase HUT06_RS17840 ENOG4108M9J MaoC like domain protein HUT06_RS17845 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT06_RS17850 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT06_RS17855 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT06_RS17860 ENOG4108K8U Glycerol operon regulatory protein HUT06_RS17865 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT06_RS17870 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS17875 ENOG4108WYP Transcriptional regulator HUT06_RS17880 ENOG4105CGU Enoyl-CoA hydratase HUT06_RS17885 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS17895 ENOG4105CPC Aldo Keto reductase HUT06_RS17905 ENOG4105EA8 2-Nitropropane dioxygenase HUT06_RS17920 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS17925 ENOG4108R85 Short chain dehydrogenase HUT06_RS17930 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT06_RS17935 ENOG4107QPV Serine Threonine protein kinase HUT06_RS17940 ENOG4105CQ7 ATP-dependent helicase HUT06_RS17975 ENOG4105DKW ABC transporter HUT06_RS18025 ENOG4108ZJI phenylacetic acid degradation protein HUT06_RS18050 ENOG4105CJ1 ABC, transporter HUT06_RS18055 ENOG4105BZU Histidine kinase HUT06_RS18060 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS18195 ENOG4108KEZ Dehydrogenase HUT06_RS18210 ENOG4105C2J ABC transporter HUT06_RS18230 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS18255 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT06_RS18295 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT06_RS18305 ENOG4105BZU Histidine kinase HUT06_RS18325 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT06_RS18335 ENOG41080RH Thioredoxin HUT06_RS18405 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT06_RS18420 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS18425 ENOG4107SCK Monooxygenase HUT06_RS18430 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT06_RS18440 ENOG4106YKD Cytochrome p-450 HUT06_RS18480 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT06_RS18490 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT06_RS18495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS18500 ENOG4105C3U ABC transporter HUT06_RS18505 ENOG4108JQ7 (ABC) transporter HUT06_RS18535 ENOG4105BZU Histidine kinase HUT06_RS18545 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT06_RS18550 ENOG4105FUA antagonist HUT06_RS18555 ENOG4107MMM Anti-sigma-factor antagonist HUT06_RS18590 ENOG4105C5H ABC transporter HUT06_RS18620 ENOG4108Z6Z Transcriptional regulator HUT06_RS18630 ENOG4105KVH Transcriptional regulator HUT06_RS18645 ENOG4105DJB Major Facilitator Superfamily HUT06_RS18710 ENOG4105DDW LysR family Transcriptional regulator HUT06_RS18740 ENOG4105IKQ hydratase HUT06_RS18755 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) HUT06_RS18765 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT06_RS18770 ENOG4105VEQ Cold shock protein HUT06_RS18780 ENOG41066F8 ROK family HUT06_RS18785 ENOG410630P Transcriptional regulator HUT06_RS18790 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS18800 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT06_RS18805 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS18810 ENOG4108ZGX Histidine kinase HUT06_RS18815 ENOG4108YRB methyltransferase HUT06_RS18825 ENOG4105C22 threonyL-tRNA synthetase HUT06_RS18870 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT06_RS18875 ENOG4105E2K Glycosyl transferase (Group 1 HUT06_RS18890 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT06_RS18900 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT06_RS18905 ENOG4105CDY transcriptional regulatory protein HUT06_RS18910 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUT06_RS18915 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT06_RS18920 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT06_RS18925 ENOG4105VIE preprotein translocase, subunit YajC HUT06_RS18930 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT06_RS18935 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT06_RS18940 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT06_RS18945 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT06_RS18950 ENOG4105C9M aspartyl-trna synthetase HUT06_RS18955 ENOG4105CUT histidyl-tRNA synthetase HUT06_RS18965 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUT06_RS18970 ENOG4105C99 atpase involved in dna repair HUT06_RS19010 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT06_RS19015 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT06_RS19025 ENOG4105E2X shikimate dehydrogenase HUT06_RS19055 ENOG41084BS 50S ribosomal protein L35 HUT06_RS19060 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT06_RS19065 ENOG4108RWN rrna methyltransferase HUT06_RS19075 ENOG4105BZU Histidine kinase HUT06_RS19080 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT06_RS19085 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT06_RS19100 ENOG4108IUW ABC transporter HUT06_RS19105 ENOG4107SM8 Adenylate Guanylate cyclase HUT06_RS19135 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT06_RS19140 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT06_RS19145 ENOG4105CAS nag kinase HUT06_RS19150 ENOG4105C8Y Acetylornithine aminotransferase HUT06_RS19155 ENOG4105DBV ornithine carbamoyltransferase HUT06_RS19160 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUT06_RS19165 ENOG4105CDH Citrulline--aspartate ligase HUT06_RS19170 ENOG4105CH7 arginosuccinase HUT06_RS19175 ENOG4108VX5 3-methyladenine DNA glycosylase HUT06_RS19180 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT06_RS19220 ENOG4108IG5 Transcriptional regulator HUT06_RS19230 ENOG4107QX3 carboxylase HUT06_RS19260 ENOG4108KGH TRANSCRIPTIONal HUT06_RS19295 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT06_RS19320 ENOG4105CHM Aminotransferase HUT06_RS19335 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT06_RS19340 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HUT06_RS19360 ENOG4106F60 Histidine kinase HUT06_RS19365 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT06_RS19380 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS19385 ENOG4107RBB ABC transporter, permease HUT06_RS19390 ENOG41061H0 Monooxygenase HUT06_RS19415 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT06_RS19420 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS19435 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT06_RS19445 ENOG41065HY 1,4-beta-cellobiosidase HUT06_RS19455 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS19460 ENOG4105CYP glycoside hydrolase, family HUT06_RS19465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT06_RS19485 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS19520 ENOG4105C0Z ABC transporter HUT06_RS19525 ENOG4108IV0 ABC, transporter HUT06_RS19560 ENOG4105DQ5 transport system permease protein HUT06_RS19565 ENOG4105TVJ transport system, permease HUT06_RS19570 ENOG4105E0A ABC, transporter HUT06_RS19580 ENOG4105E8G Major facilitator Superfamily HUT06_RS19585 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT06_RS19590 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT06_RS19650 ENOG4105J76 Periplasmic binding protein HUT06_RS19670 ENOG4105DXB Major Facilitator superfamily HUT06_RS19690 ENOG4108IG5 Transcriptional regulator HUT06_RS19695 ENOG4105C0Z ABC transporter HUT06_RS19700 ENOG4108IV0 ABC, transporter HUT06_RS19720 ENOG4105E98 transcriptional regulator DeoR family HUT06_RS19725 ENOG410849S phosphocarrier protein (HPr) HUT06_RS19730 ENOG4105CPQ Dehydrogenase HUT06_RS19735 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT06_RS19750 ENOG4105DE4 1-phosphofructokinase HUT06_RS19760 ENOG4105PP6 Membrane HUT06_RS19795 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT06_RS19810 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS19850 ENOG4105D9R oxidoreductase HUT06_RS19880 ENOG410814C multidrug resistance protein HUT06_RS19895 ENOG4105C26 Dehydrogenase HUT06_RS19925 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT06_RS19935 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT06_RS19940 ENOG4108MRH transcriptional regulatory protein HUT06_RS19945 ENOG4108IUW ABC transporter HUT06_RS19960 ENOG4105CD8 aminopeptidase N HUT06_RS19975 ENOG4105C3Q Glycosyl transferase, family 2 HUT06_RS19980 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS19985 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT06_RS20020 ENOG4105CHR reductase HUT06_RS20030 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT06_RS20035 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT06_RS20055 ENOG4105KA0 thioesterase Superfamily protein HUT06_RS20070 ENOG4108Z86 Glutamine amidotransferase HUT06_RS20100 ENOG4105E0Y RtcB Protein HUT06_RS20110 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HUT06_RS20120 ENOG4107FW0 short-chain dehydrogenase reductase HUT06_RS20125 ENOG4105EEM helicase HUT06_RS20140 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS20145 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS20150 ENOG4105K6H D-cysteine desulfhydrase HUT06_RS20155 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT06_RS20165 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HUT06_RS20190 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT06_RS20200 ENOG4108K8U Glycerol operon regulatory protein HUT06_RS20210 ENOG4105EYF MMPL domain protein HUT06_RS20250 ENOG4106IPI cyclase, family HUT06_RS20260 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT06_RS20265 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT06_RS20285 ENOG41083YR Protein CrcB homolog HUT06_RS20290 ENOG41083TI Protein CrcB homolog HUT06_RS20315 ENOG4106517 Short-chain dehydrogenase reductase Sdr HUT06_RS20320 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT06_RS20325 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT06_RS20330 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT06_RS20340 ENOG4105DKP glycosyl transferase, family 9 HUT06_RS20345 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUT06_RS20380 ENOG4108V1U phospholipid-binding protein HUT06_RS20385 ENOG4105CPC Aldo Keto reductase HUT06_RS20390 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS20395 ENOG4105DXM phenylacetic acid degradation protein HUT06_RS20400 ENOG4105GZI Transcriptional regulator HUT06_RS20405 ENOG4105D82 Glutamate dehydrogenase HUT06_RS20415 ENOG4105C26 Dehydrogenase HUT06_RS20420 ENOG4105CPP Dehydrogenase, E1 component HUT06_RS20425 ENOG4108IV0 ABC, transporter HUT06_RS20430 ENOG4105C0Z ABC transporter HUT06_RS20435 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS20470 ENOG4107QP8 phosphohexose isomerase HUT06_RS20485 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HUT06_RS20500 ENOG4105FDP GntR family transcriptional regulator HUT06_RS20520 ENOG4107S9F NmrA family HUT06_RS20545 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT06_RS20550 ENOG4105BZU Histidine kinase HUT06_RS20565 ENOG4107SQD Transcriptional regulator, GntR family HUT06_RS20570 ENOG4105N14 lysine exporter protein LysE YggA HUT06_RS20615 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT06_RS20640 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT06_RS20645 ENOG4107QR9 Iron-sulfur cluster binding protein HUT06_RS20650 ENOG41080R8 Conserved Protein HUT06_RS20670 ENOG4107QND Nitrite extrusion protein HUT06_RS20685 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT06_RS20690 ENOG4105WZK nitrite reductase NADPH small subunit HUT06_RS20725 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT06_RS20745 ENOG4107TCW O-succinylbenzoate synthase HUT06_RS20750 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HUT06_RS20775 ENOG4107S91 Sodium hydrogen exchanger HUT06_RS20785 ENOG4105E4F Isochorismate synthase HUT06_RS20800 ENOG4105CHR reductase HUT06_RS20840 ENOG4108C33 Resolvase HUT06_RS20855 ENOG4105F32 YngK protein HUT06_RS20925 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT06_RS20975 ENOG4105C57 major facilitator superfamily HUT06_RS20980 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS20985 ENOG4108ZGX Histidine kinase HUT06_RS20990 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT06_RS21010 ENOG410681U heavy metal transport detoxification protein HUT06_RS21025 ENOG4108JU3 Alkyl hydroperoxide reductase HUT06_RS21075 ENOG4108JQ7 (ABC) transporter HUT06_RS21115 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT06_RS21135 ENOG4108NIW Leucine export protein LeuE HUT06_RS21145 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT06_RS21205 ENOG4106H3A restriction HUT06_RS21325 ENOG4105EYH Exonuclease HUT06_RS21335 ENOG4105CSH Transporter HUT06_RS21405 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT06_RS21455 ENOG410836F Transposase HUT06_RS21590 ENOG4105C0D helicase HUT06_RS21630 ENOG4108KPJ rna polymerase sigma factor HUT06_RS21685 ENOG410630P Transcriptional regulator HUT06_RS21705 ENOG4108ZT1 Transcriptional regulator HUT06_RS21710 ENOG4108FFZ Transcriptional regulator HUT06_RS21725 ENOG4105D65 subunit l HUT06_RS21760 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT06_RS21770 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HUT06_RS21790 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HUT06_RS21800 ENOG4107ETC gas vesicle protein HUT06_RS21805 ENOG4108XNA Gas vesicle HUT06_RS21810 ENOG4107SWE Methyltransferase HUT06_RS21820 ENOG4108JJ8 (ABC) transporter HUT06_RS21825 ENOG4105BZ1 (ABC) transporter HUT06_RS21835 ENOG4108JJ9 ABC, transporter HUT06_RS21845 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT06_RS21920 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS21930 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT06_RS21950 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HUT06_RS21960 ENOG4108NBA ATP-dependent carboxylate-amine ligase (By similarity) HUT06_RS21975 ENOG4105GRZ Ycii-related protein HUT06_RS21990 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUT06_RS22035 ENOG4108W5M transcriptional regulator HUT06_RS22040 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT06_RS22055 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HUT06_RS22100 ENOG410905P Pyridoxamine 5-phosphate HUT06_RS22120 ENOG4105CHR reductase HUT06_RS22130 ENOG410842T Pterin carbinolamine dehydratase HUT06_RS22135 ENOG4105EDW glycosyl transferase, family 39 HUT06_RS22135 ENOG4105EDW glycosyl transferase, family 39 HUT06_RS22140 ENOG4105EDW glycosyl transferase, family 39 HUT06_RS22150 ENOG41062D9 Histidine kinase HUT06_RS22155 ENOG4105ETX regulatoR HUT06_RS22165 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT06_RS22215 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT06_RS22225 ENOG4107QVM von Willebrand factor, type A HUT06_RS22230 ENOG4107Y49 methyltransferase HUT06_RS22240 ENOG4105SCY DNAK suppressor HUT06_RS22255 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT06_RS22275 ENOG4108IGT Dipeptidase HUT06_RS22285 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT06_RS22290 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT06_RS22295 ENOG4105Q70 HUT06_RS22300 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS22315 ENOG4105FS0 cytoplasmic membrane protein HUT06_RS22320 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT06_RS22330 ENOG4108UYI beta-alanyl-CoA ammonia lyase HUT06_RS22335 ENOG4107CHF 5,6-aminomutase beta subunit HUT06_RS22340 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit HUT06_RS22370 ENOG4105FRY Dehydrogenase HUT06_RS22375 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HUT06_RS22390 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS22400 ENOG4105DKQ ROK family HUT06_RS22410 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT06_RS22415 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT06_RS22420 ENOG4105F8D glycoside hydrolase family 4 HUT06_RS22435 ENOG4105EW9 transcriptional regulator AsnC family HUT06_RS22440 ENOG41060NJ transcriptional regulator HUT06_RS22450 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT06_RS22455 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HUT06_RS22460 ENOG4105EPJ extracellular solute-binding protein family 1 HUT06_RS22475 ENOG4105HFS 5'-3' exonuclease HUT06_RS22515 ENOG4108IFG nitrite reductase, (NAD(P)H) HUT06_RS22520 ENOG4107QZF nitrite reductase NADPH large subunit HUT06_RS22535 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT06_RS22555 ENOG4105CQB FAD linked oxidase domain protein HUT06_RS22560 ENOG4105BZP glycoside hydrolase 15-related HUT06_RS22570 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS22585 ENOG4105CJ1 ABC, transporter HUT06_RS22600 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUT06_RS22605 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT06_RS22645 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT06_RS22650 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT06_RS22655 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT06_RS22675 ENOG4105E5F proteasome HUT06_RS22680 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT06_RS22700 ENOG4108ZGX Histidine kinase HUT06_RS22705 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS22710 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS22715 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS22725 ENOG4105C3U ABC transporter HUT06_RS22740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS22750 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HUT06_RS22765 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HUT06_RS22770 ENOG4108762 serine threonine protein kinase HUT06_RS22775 ENOG4105C8N cysteinyl-tRNA synthetase HUT06_RS22785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS22815 ENOG4105D7N magnesium and cobalt transport protein CorA HUT06_RS22825 ENOG4105CPC Aldo Keto reductase HUT06_RS22830 ENOG4105C7H Helicase, RecD TraA family HUT06_RS22845 ENOG4105CHR reductase HUT06_RS22860 ENOG4105WKW Pfam:DUF1458 HUT06_RS22895 ENOG4105D5P Methylmalonyl-coA mutase HUT06_RS22915 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT06_RS22940 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT06_RS22945 ENOG4105E5G Alpha beta hydrolase fold HUT06_RS22955 ENOG4105E0Y RtcB Protein HUT06_RS22960 ENOG4105EM7 Selenocysteine-specific translation elongation factor HUT06_RS22970 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT06_RS22980 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HUT06_RS23005 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT06_RS23025 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUT06_RS23030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT06_RS23035 ENOG4108VW9 Membrane HUT06_RS23040 ENOG4105BZW Glycerate kinase HUT06_RS23050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT06_RS23055 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUT06_RS23065 ENOG4105BZ1 (ABC) transporter HUT06_RS23070 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HUT06_RS23085 ENOG4105C5H ABC transporter HUT06_RS23120 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS23125 ENOG4105BZU Histidine kinase HUT06_RS23130 ENOG4105IIP Membrane HUT06_RS23135 ENOG4105VG1 fes assembly suf system protein HUT06_RS23140 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT06_RS23150 ENOG4105C3K feS assembly ATPase SufC HUT06_RS23160 ENOG4105JRK feS assembly protein SufD HUT06_RS23180 ENOG4105CUB amino acid HUT06_RS23190 ENOG4105DBV ornithine carbamoyltransferase HUT06_RS23200 ENOG4105CJ1 ABC, transporter HUT06_RS23215 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT06_RS23220 ENOG4105DCG PHP domain protein HUT06_RS23225 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HUT06_RS23235 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT06_RS23245 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT06_RS23255 ENOG4107QYV phosphohexose isomerase HUT06_RS23260 ENOG4107QP8 phosphohexose isomerase HUT06_RS23275 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT06_RS23280 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT06_RS23295 ENOG4108Z4U Ferredoxin HUT06_RS23300 ENOG4105BZU Histidine kinase HUT06_RS23310 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS23340 ENOG4105BZU Histidine kinase HUT06_RS23345 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS23355 ENOG4105EYF MMPL domain protein HUT06_RS23370 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT06_RS23400 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUT06_RS23410 ENOG4108TCJ secreted hydrolase HUT06_RS23440 ENOG4108IND Tetr family transcriptional regulator HUT06_RS23475 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUT06_RS23495 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HUT06_RS23515 ENOG4108IV0 ABC, transporter HUT06_RS23520 ENOG4105C0Z ABC transporter HUT06_RS23530 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS23540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS23545 ENOG4105CI0 Citrate lyase HUT06_RS23555 ENOG4108PGP mmge prpd family protein HUT06_RS23590 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT06_RS23600 ENOG4105F7P transcriptional regulator AsnC family HUT06_RS23615 ENOG4105CP7 Triose-phosphate isomerase HUT06_RS23620 ENOG4105BZA Phosphoglycerate kinase HUT06_RS23625 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT06_RS23645 ENOG4105CIE May be required for sporulation (By similarity) HUT06_RS23650 ENOG4105CHW UPF0052 protein HUT06_RS23655 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT06_RS23660 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT06_RS23675 ENOG4105VQD rieske 2fe-2S domain-containing protein HUT06_RS23680 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT06_RS23710 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT06_RS23755 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT06_RS23770 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS23805 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT06_RS23810 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT06_RS23830 ENOG4105DSU hydrolase HUT06_RS23890 ENOG41060WC Enoyl-CoA hydratase HUT06_RS23910 ENOG4107TYG Oxidoreductase domain-containing protein HUT06_RS23940 ENOG4108IUE nitrate reductase beta subunit HUT06_RS23980 ENOG4105DY8 decarboxylase HUT06_RS23985 ENOG4105CQB FAD linked oxidase domain protein HUT06_RS23990 ENOG41069M3 Transcriptional regulator HUT06_RS23995 ENOG4105IKQ hydratase HUT06_RS24025 ENOG4108YYQ gCN5-related N-acetyltransferase HUT06_RS24035 ENOG4105C1J atp-dependent rna helicase HUT06_RS24040 ENOG4105VEQ Cold shock protein HUT06_RS24070 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT06_RS24125 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUT06_RS24160 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT06_RS24165 ENOG4105VEQ Cold shock protein HUT06_RS24215 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT06_RS24235 ENOG4105DIA mandelate racemase muconate lactonizing HUT06_RS24250 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT06_RS24255 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT06_RS24260 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT06_RS24270 ENOG4105DDC Oxidoreductase domain protein HUT06_RS24290 ENOG41083TI Protein CrcB homolog HUT06_RS24295 ENOG4107PI4 Protein CrcB homolog HUT06_RS24300 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HUT06_RS24305 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT06_RS24325 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUT06_RS24340 ENOG4105C0X amino acid HUT06_RS24345 ENOG4105CI0 Citrate lyase HUT06_RS24350 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS24370 ENOG410900P UPF0336 protein HUT06_RS24385 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS24390 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT06_RS24395 ENOG4105DJG MaoC domain protein dehydratase HUT06_RS24410 ENOG4105FDP GntR family transcriptional regulator HUT06_RS24415 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS24425 ENOG4108IV0 ABC, transporter HUT06_RS24430 ENOG4105C0Z ABC transporter HUT06_RS24435 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS24480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS24485 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT06_RS24510 ENOG4108K8U Glycerol operon regulatory protein HUT06_RS24530 ENOG4107EFR Flavocytochrome c HUT06_RS24580 ENOG4107HP6 Transcriptional regulator HUT06_RS24600 ENOG410834F Transcriptional regulator HUT06_RS24630 ENOG4105FQP Beta-lactamase HUT06_RS24635 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT06_RS24665 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT06_RS24670 ENOG4105CUB amino acid HUT06_RS24675 ENOG4105E98 transcriptional regulator DeoR family HUT06_RS24680 ENOG41067SE Tetr family transcriptional regulator HUT06_RS24685 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT06_RS24690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT06_RS24700 ENOG4105BZU Histidine kinase HUT06_RS24705 ENOG4108S01 response regulator HUT06_RS24715 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT06_RS24725 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT06_RS24730 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS24735 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HUT06_RS24755 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT06_RS24775 ENOG4105CJ1 ABC, transporter HUT06_RS24825 ENOG4105CHR reductase HUT06_RS24830 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT06_RS24835 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS24840 ENOG4105EHG Permease protein HUT06_RS24850 ENOG4105EHG Permease protein HUT06_RS24855 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS24865 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT06_RS24870 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT06_RS24875 ENOG41087PP glycosyltransferase MGT family HUT06_RS24895 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT06_RS24915 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS24945 ENOG4105DG4 malate L-lactate dehydrogenase HUT06_RS24970 ENOG4105ERH Fumarylacetoacetate hydrolase HUT06_RS25020 ENOG4105DFW ABC transporter HUT06_RS25025 ENOG4105CNN ABC, transporter HUT06_RS25030 ENOG4105C2J ABC transporter HUT06_RS25065 ENOG4105C7S Dehydrogenase HUT06_RS25105 ENOG41082SX arsR family transcriptional regulator HUT06_RS25115 ENOG4108RWP Major Facilitator Superfamily protein HUT06_RS25130 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT06_RS25135 ENOG4108X0B nad(p)h dehydrogenase (quinone) HUT06_RS25140 ENOG4107UB2 Alpha beta hydrolase fold HUT06_RS25150 ENOG4105M2Z protein tyrosine serine phosphatase HUT06_RS25205 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HUT06_RS25230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT06_RS25235 ENOG41081E8 Alpha beta hydrolase HUT06_RS25250 ENOG4105C2J ABC transporter HUT06_RS25255 ENOG4105CNN ABC, transporter HUT06_RS25260 ENOG4105CNN ABC, transporter HUT06_RS25275 ENOG4107HP6 Transcriptional regulator HUT06_RS25285 ENOG4108UHU Aldolase HUT06_RS25295 ENOG4105KME endoribonuclease L-psp HUT06_RS25305 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS25325 ENOG4105CIR epoxide hydrolase HUT06_RS25330 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUT06_RS25335 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUT06_RS25340 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS25345 ENOG4108ZGX Histidine kinase HUT06_RS25355 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT06_RS25385 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HUT06_RS25390 ENOG4105CHH sulfate transporter HUT06_RS25395 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT06_RS25400 ENOG4105C7S Dehydrogenase HUT06_RS25405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS25440 ENOG4105C26 Dehydrogenase HUT06_RS25445 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT06_RS25450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT06_RS25455 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT06_RS25485 ENOG4105CHM Aminotransferase HUT06_RS25490 ENOG4105DRR Transcriptional regulator, GntR family HUT06_RS25510 ENOG4107SVN transposase HUT06_RS25535 ENOG4105D5G Transposase HUT06_RS25570 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT06_RS25585 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT06_RS25625 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HUT06_RS25635 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HUT06_RS25645 ENOG4105EWK phytoene HUT06_RS25685 ENOG41080XQ Signal transduction protein with cbs domains HUT06_RS25720 ENOG4105CIG ABC transporter HUT06_RS25740 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase HUT06_RS25750 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT06_RS25760 ENOG4105BZU Histidine kinase HUT06_RS25765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS25770 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT06_RS25820 ENOG4107VFM Dehydrogenase HUT06_RS25870 ENOG4108YV4 Universal stress protein HUT06_RS25875 ENOG4105D5Q Arginine ornithine antiporter HUT06_RS25885 ENOG4105DBV ornithine carbamoyltransferase HUT06_RS25970 ENOG4108YV4 Universal stress protein HUT06_RS26040 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HUT06_RS26045 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS26050 ENOG4108MUZ hydrolase HUT06_RS26060 ENOG4108R85 Short chain dehydrogenase HUT06_RS26065 ENOG4105CGU Enoyl-CoA hydratase HUT06_RS26085 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS26090 ENOG4108IV0 ABC, transporter HUT06_RS26095 ENOG4105C0Z ABC transporter HUT06_RS26100 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS26105 ENOG4105CP9 extracellular ligand-binding receptor HUT06_RS26190 ENOG4105D5G Transposase HUT06_RS26210 ENOG4105KF0 sporulation and cell division protein, SsgA HUT06_RS26235 ENOG4105C8I hydrolase, family 38 HUT06_RS26240 ENOG4105DB7 PHP domain protein HUT06_RS26250 ENOG4105DRS transport system, permease HUT06_RS26270 ENOG4108ZHR arsR family transcriptional regulator HUT06_RS26320 ENOG4105DE4 1-phosphofructokinase HUT06_RS26360 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HUT06_RS26365 ENOG4105F0N pyrophosphate phospho-hydrolase HUT06_RS26415 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS26445 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HUT06_RS26470 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT06_RS26480 ENOG4108W63 CRP FNR family transcriptional regulator HUT06_RS26520 ENOG4108R85 Short chain dehydrogenase HUT06_RS26530 ENOG4105F38 ABC transporter, permease HUT06_RS26545 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS26555 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUT06_RS26585 ENOG4108UZX fmn reductase HUT06_RS26590 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT06_RS26595 ENOG4108Z6Z Transcriptional regulator HUT06_RS26605 ENOG4108YYC ycei family HUT06_RS26650 ENOG4108J2P Alpha beta hydrolase fold HUT06_RS26655 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUT06_RS26660 ENOG410680H amp-dependent synthetase and ligase HUT06_RS26665 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT06_RS26685 ENOG4107S46 esterase, PHB depolymerase HUT06_RS26700 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HUT06_RS26705 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT06_RS26710 ENOG4105CTK cobaltochelatase, cobn subunit HUT06_RS26720 ENOG41081F0 Precorrin-8x methylmutase HUT06_RS26740 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUT06_RS26755 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT06_RS26770 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT06_RS26775 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS26800 ENOG4107HP6 Transcriptional regulator HUT06_RS26815 ENOG4105CHR reductase HUT06_RS26840 ENOG4105F95 Monooxygenase HUT06_RS26855 ENOG4105E2R ROK family HUT06_RS26860 ENOG4105CDA abc transporter atp-binding protein HUT06_RS26865 ENOG4107UBR Extracellular solute-binding protein family 3 HUT06_RS26870 ENOG4105EAD ABC transporter HUT06_RS26875 ENOG4105DRP amino acid AbC transporter HUT06_RS26885 ENOG4106N3A copper homeostasis protein cutc HUT06_RS26890 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT06_RS26905 ENOG4105CG3 alpha amylase, catalytic region HUT06_RS26910 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HUT06_RS26925 ENOG4105E2Y ABC, transporter HUT06_RS26935 ENOG4105DFF Rod shape-determining protein mreb HUT06_RS26950 ENOG4107QNK )-transporter HUT06_RS26955 ENOG410903U zinc ion binding HUT06_RS26960 ENOG4105DEG Vwa containing coxe family protein HUT06_RS26965 ENOG4105RD5 HUT06_RS26970 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT06_RS26975 ENOG4108KDT Molybdate metabolism regulator HUT06_RS26995 ENOG4108VQT Alpha beta hydrolase fold protein HUT06_RS27005 ENOG4105C28 cystathionine HUT06_RS27015 ENOG4108KDT Molybdate metabolism regulator HUT06_RS27020 ENOG4108KDT Molybdate metabolism regulator HUT06_RS27025 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUT06_RS27035 ENOG4105C5F glutamine synthetase HUT06_RS27075 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS27080 ENOG4105J7D transcriptional regulator HUT06_RS27085 ENOG4105C8F Beta-lactamase domain protein HUT06_RS27090 ENOG4105C7H Helicase, RecD TraA family HUT06_RS27100 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT06_RS27110 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT06_RS27115 ENOG4105C0B DNA polymerase III (alpha subunit) HUT06_RS27125 ENOG4107R33 ppx gppa phosphatase HUT06_RS27135 ENOG4108RVA ribokinase HUT06_RS27155 ENOG4105CV8 reductase HUT06_RS27210 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HUT06_RS27215 ENOG4105D4B ABC, transporter HUT06_RS27220 ENOG4105F5R ABC transporter HUT06_RS27230 ENOG4105C2J ABC transporter HUT06_RS27235 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS27240 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT06_RS27250 ENOG41080R8 Conserved Protein HUT06_RS27255 ENOG4105DET Rhamnulokinase HUT06_RS27260 ENOG4107SM8 Adenylate Guanylate cyclase HUT06_RS27280 ENOG410905P Pyridoxamine 5-phosphate HUT06_RS27320 ENOG4105CQ7 ATP-dependent helicase HUT06_RS27345 ENOG4107W6X Transcriptional regulator HUT06_RS27365 ENOG4105CHU acetyl-coa acetyltransferase HUT06_RS27375 ENOG4107KBT 8-Amino-7-oxononanoate synthase HUT06_RS27395 ENOG4108TCJ secreted hydrolase HUT06_RS27400 ENOG4105CY0 Metallo-Beta-Lactamase HUT06_RS27410 ENOG41080UX Methyltransferase HUT06_RS27440 ENOG4105K4I Scp-like extracellular HUT06_RS27490 ENOG4105CPQ Dehydrogenase HUT06_RS27510 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HUT06_RS27520 ENOG4107Z6X Transcriptional regulator HUT06_RS27580 ENOG4105ENA helicase HUT06_RS27595 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT06_RS27630 ENOG4105EYF MMPL domain protein HUT06_RS27635 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS27640 ENOG4105BZU Histidine kinase HUT06_RS27665 ENOG4105C57 major facilitator superfamily HUT06_RS27705 ENOG4105D64 Mechanosensitive ion channel HUT06_RS27725 ENOG4105CPK Glycosyl transferase (Group 1 HUT06_RS27730 ENOG4107SM8 Adenylate Guanylate cyclase HUT06_RS27750 ENOG4105CJA serine threonine protein kinase HUT06_RS27785 ENOG4107S5T Carbohydrate kinase HUT06_RS27790 ENOG4105E98 transcriptional regulator DeoR family HUT06_RS27850 ENOG4105WQT MbtH domain protein HUT06_RS27855 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS27860 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS27890 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT06_RS27900 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS27930 ENOG4107W7X Aldolase HUT06_RS27940 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS27955 ENOG4105CFG Acts as a chaperone (By similarity) HUT06_RS27980 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT06_RS27985 ENOG41067SE Tetr family transcriptional regulator HUT06_RS28020 ENOG4105DV0 amidase (EC 3.5.1.4 HUT06_RS28025 ENOG4105F9U Dehydrogenase HUT06_RS28045 ENOG41073TP transcriptional regulator HUT06_RS28050 ENOG4108JPW Aminotransferase HUT06_RS28055 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS28065 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT06_RS28080 ENOG410846T CoA-transferase family III HUT06_RS28100 ENOG4105C7B Threonine dehydratase HUT06_RS28125 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT06_RS28145 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT06_RS28150 ENOG4105RD5 HUT06_RS28155 ENOG4105DEG Vwa containing coxe family protein HUT06_RS28185 ENOG4106R7G Glycoside hydrolase family 5 HUT06_RS28190 ENOG4106R7G Glycoside hydrolase family 5 HUT06_RS28195 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT06_RS28210 ENOG4105CBD Diacylglycerol kinase HUT06_RS28220 ENOG4107S5I aldo keto reductase HUT06_RS28250 ENOG4107RN6 Monooxygenase HUT06_RS28255 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT06_RS28265 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT06_RS28275 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT06_RS28295 ENOG4105E3B Multicopper oxidase HUT06_RS28315 ENOG4105EYH Exonuclease HUT06_RS28330 ENOG4108Z6B deaminase HUT06_RS28375 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT06_RS28380 ENOG4105CAY ferredoxin--nadp reductase HUT06_RS28390 ENOG4105C2J ABC transporter HUT06_RS28395 ENOG41062B0 ABC transporter, permease HUT06_RS28405 ENOG4105DH8 myo-inositol catabolism HUT06_RS28420 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT06_RS28435 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT06_RS28470 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT06_RS28495 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT06_RS28510 ENOG4108V06 Glutathione peroxidase HUT06_RS28530 ENOG4108KGH TRANSCRIPTIONal HUT06_RS28535 ENOG4105BZ1 (ABC) transporter HUT06_RS28540 ENOG4106F1P AAA ATPase, central domain protein HUT06_RS28545 ENOG41082AN stage II sporulation protein HUT06_RS28565 ENOG4105GWZ Roadblock lc7 family protein HUT06_RS28570 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HUT06_RS28585 ENOG4105DG7 nitrate ABC transporter HUT06_RS28590 ENOG4105FP9 thiamine pyrophosphate HUT06_RS28600 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT06_RS28605 ENOG4105DG7 nitrate ABC transporter HUT06_RS28610 ENOG4105D7T ABC transporter HUT06_RS28615 ENOG41061H0 Monooxygenase HUT06_RS28705 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT06_RS28725 ENOG4105CSU acyl-Coa dehydrogenase HUT06_RS28745 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS28750 ENOG4105BZU Histidine kinase HUT06_RS28845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUT06_RS28855 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HUT06_RS28870 ENOG4105CGD Nad-dependent epimerase dehydratase HUT06_RS28880 ENOG4108Z4X TRANSCRIPTIONal HUT06_RS28885 ENOG4108JGH Tetr family transcriptional regulator HUT06_RS28890 ENOG4105C57 major facilitator superfamily HUT06_RS28900 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT06_RS28905 ENOG4107UNS conserved inner membrane protein HUT06_RS28910 ENOG4105E98 transcriptional regulator DeoR family HUT06_RS28935 ENOG4105WCJ ec 1.1.1.193 HUT06_RS28950 ENOG4105DGI Alkaline phosphatase HUT06_RS28960 ENOG4105JXH GntR family transcriptional regulator HUT06_RS28965 ENOG4107SNV Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT06_RS28990 ENOG4105E0X reductase HUT06_RS29000 ENOG4107JTW chlorite dismutase HUT06_RS29005 ENOG4105C1Q protoporphyrinogen oxidase HUT06_RS29025 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT06_RS29055 ENOG4107RBB ABC transporter, permease HUT06_RS29060 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS29080 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT06_RS29085 ENOG4106F60 Histidine kinase HUT06_RS29090 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS29155 ENOG4107QVI Methyltransferase, type 11 HUT06_RS29160 ENOG4105DIM ABC transporter HUT06_RS29165 ENOG4105CIG ABC transporter HUT06_RS29170 ENOG4105D74 hydrolase HUT06_RS29190 ENOG4106A3M Cytochrome p-450 HUT06_RS29225 ENOG4105C0W non-ribosomal peptide synthetase HUT06_RS29240 ENOG4105C0W non-ribosomal peptide synthetase HUT06_RS29290 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HUT06_RS29300 ENOG4108DUX Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HUT06_RS29305 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HUT06_RS29310 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT06_RS29355 ENOG4105CHU acetyl-coa acetyltransferase HUT06_RS29360 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT06_RS29365 ENOG4105CUB amino acid HUT06_RS29385 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT06_RS29390 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT06_RS29430 ENOG4107SET aldo keto reductase HUT06_RS29435 ENOG4105N14 lysine exporter protein LysE YggA HUT06_RS29440 ENOG4107QM5 aconitate hydratase HUT06_RS29455 ENOG4105EBR Carboxylesterase HUT06_RS29475 ENOG4105FBD synthase HUT06_RS29485 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT06_RS29495 ENOG4105EWU Squalene--hopene cyclase HUT06_RS29520 ENOG4105JQN Transcriptional regulator HUT06_RS29535 ENOG4108UHU Aldolase HUT06_RS29540 ENOG4105CHC glucokinase (EC 2.7.1.2) HUT06_RS29545 ENOG4105C01 Dihydroxy-acid dehydratase HUT06_RS29565 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT06_RS29575 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT06_RS29585 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT06_RS29660 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT06_RS29680 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT06_RS29685 ENOG410756H nucleotidyltransferase HUT06_RS29695 ENOG4107T3P ABC, transporter HUT06_RS29710 ENOG4105CG3 alpha amylase, catalytic region HUT06_RS29715 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS29730 ENOG4105DRS transport system, permease HUT06_RS29740 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS29770 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT06_RS29775 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS29780 ENOG4105F27 Major Facilitator HUT06_RS29790 ENOG4105CJQ hydrolase, family 31 HUT06_RS29795 ENOG4105DRS transport system, permease HUT06_RS29800 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT06_RS29815 ENOG4105CFM UPF0317 protein HUT06_RS29820 ENOG4107R7A Allophanate hydrolase subunit 2 HUT06_RS29825 ENOG4105P4J Allophanate hydrolase, subunit 1 HUT06_RS29830 ENOG4105C5A transporter HUT06_RS29835 ENOG4105FDP GntR family transcriptional regulator HUT06_RS29840 ENOG4108PVQ transcriptional regulator HUT06_RS29845 ENOG4108JYK Dehydrogenase HUT06_RS29855 ENOG4105C7S Dehydrogenase HUT06_RS29875 ENOG4105K6V RNA polymerase HUT06_RS29880 ENOG4105RNG membrane HUT06_RS29905 ENOG4105E2R ROK family HUT06_RS29920 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT06_RS29930 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT06_RS29965 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT06_RS29970 ENOG4105EIP mannose-6-phosphate isomerase HUT06_RS29985 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS30000 ENOG4107S1Q Phosphatase HUT06_RS30005 ENOG4105DXX methyltransferase HUT06_RS30045 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT06_RS30050 ENOG4105C0X amino acid HUT06_RS30055 ENOG4107VEG TrkA-N domain protein HUT06_RS30080 ENOG4105C19 ABC transporter HUT06_RS30105 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT06_RS30145 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT06_RS30155 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT06_RS30180 ENOG4106F60 Histidine kinase HUT06_RS30185 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT06_RS30200 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT06_RS30205 ENOG4105FAA peptidase M23 HUT06_RS30230 ENOG410905X membrane-flanked domain protein HUT06_RS30255 ENOG4108V1U phospholipid-binding protein HUT06_RS30265 ENOG4105CHH sulfate transporter HUT06_RS30290 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT06_RS30295 ENOG4108JQ7 (ABC) transporter HUT06_RS30300 ENOG4105C3U ABC transporter HUT06_RS30310 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT06_RS30315 ENOG4105JXH GntR family transcriptional regulator HUT06_RS30335 ENOG4105EGD dinuclear metal center protein, YbgI family HUT06_RS30410 ENOG4107R5B glutamine synthetase HUT06_RS30465 ENOG41080XP Cbs domain HUT06_RS30475 ENOG4106F1P AAA ATPase, central domain protein HUT06_RS30480 ENOG4108VFZ ribulose bisphosphate carboxylase, small HUT06_RS30485 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HUT06_RS30490 ENOG4105DZ2 Transcriptional regulator HUT06_RS30500 ENOG4105EG6 Saccharopine dehydrogenase HUT06_RS30510 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS30515 ENOG4105DBI uridine monophosphokinase HUT06_RS30540 ENOG4107ZED Uncharacterised protein family UPF0047 HUT06_RS30550 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT06_RS30570 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS30580 ENOG4108ZT1 Transcriptional regulator HUT06_RS30590 ENOG4105VNT transposase (IS4 family) protein HUT06_RS30605 ENOG4107SET aldo keto reductase HUT06_RS30615 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT06_RS30630 ENOG4105D74 hydrolase HUT06_RS30650 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS30660 ENOG4108IV0 ABC, transporter HUT06_RS30665 ENOG4105C0Z ABC transporter HUT06_RS30695 ENOG4105DCG PHP domain protein HUT06_RS30700 ENOG4105BZU Histidine kinase HUT06_RS30705 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS30735 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT06_RS30740 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT06_RS30775 ENOG4105KHC sulfurtransferase HUT06_RS30820 ENOG4108JNI Alpha beta hydrolase HUT06_RS30830 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT06_RS30840 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT06_RS30890 ENOG4105D01 (LipO)protein HUT06_RS30895 ENOG4108UMI ABC transporter, permease HUT06_RS30900 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS30930 ENOG4105M4P Tetr family transcriptional regulator HUT06_RS30935 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT06_RS30950 ENOG4105BZU Histidine kinase HUT06_RS30955 ENOG4105CJ1 ABC, transporter HUT06_RS30960 ENOG4108IUK alpha amylase, catalytic HUT06_RS30965 ENOG4105DMF Dehydrogenase HUT06_RS30970 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT06_RS31010 ENOG4105D7V transposase HUT06_RS31040 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS31050 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT06_RS31055 ENOG4105CJ1 ABC, transporter HUT06_RS31075 ENOG4107XFJ UPF0246 protein HUT06_RS31080 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT06_RS31085 ENOG4105BZU Histidine kinase HUT06_RS31095 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HUT06_RS31140 ENOG4107R7A Allophanate hydrolase subunit 2 HUT06_RS31160 ENOG4108J2P Alpha beta hydrolase fold HUT06_RS31165 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT06_RS31175 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT06_RS31190 ENOG4105EUB pirin domain protein HUT06_RS31215 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT06_RS31225 ENOG41068JE domain protein HUT06_RS31230 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT06_RS31235 ENOG4105C8T Leucyl-tRNA synthetase HUT06_RS31240 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS31250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT06_RS31255 ENOG4105D74 hydrolase HUT06_RS31270 ENOG4105CPC Aldo Keto reductase HUT06_RS31275 ENOG4107TRG DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HUT06_RS31295 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT06_RS31300 ENOG4105IQ5 FAD linked oxidase domain protein HUT06_RS31330 ENOG4105CHM Aminotransferase HUT06_RS31335 ENOG4107R34 abc transporter permease protein HUT06_RS31340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS31345 ENOG4108RF4 Tetr family transcriptional regulator HUT06_RS31355 ENOG4107RN6 Monooxygenase HUT06_RS31370 ENOG4105EWC Purine nucleoside phosphorylase HUT06_RS31460 ENOG4108ZM9 phosphoglycerate mutase HUT06_RS31470 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT06_RS31475 ENOG4105DZS Phenylacetate-CoA ligase HUT06_RS31480 ENOG4105D7V transposase HUT06_RS31485 ENOG4105D0M Protease HtpX homolog HUT06_RS31495 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT06_RS31500 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT06_RS31505 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT06_RS31510 ENOG4105K46 50S ribosomal protein l27 HUT06_RS31515 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT06_RS31520 ENOG4105C03 ribonuclease HUT06_RS31535 ENOG4105CNI cell division protein FtsW HUT06_RS31540 ENOG4105CJN penicillin-binding protein HUT06_RS31555 ENOG4105DFF Rod shape-determining protein mreb HUT06_RS31560 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT06_RS31575 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT06_RS31590 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT06_RS31605 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS31610 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT06_RS31615 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT06_RS31620 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT06_RS31625 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT06_RS31635 ENOG4105BZM domain protein HUT06_RS31665 ENOG4105CHR reductase HUT06_RS31685 ENOG4105KVH Transcriptional regulator HUT06_RS31725 ENOG410905P Pyridoxamine 5-phosphate HUT06_RS31730 ENOG4105MSB protein, conserved in bacteria HUT06_RS31735 ENOG4105MSB protein, conserved in bacteria HUT06_RS31755 ENOG4105NAF rna polymerase sigma factor HUT06_RS31770 ENOG4107TUY Histidine kinase HUT06_RS31780 ENOG4105DGI Alkaline phosphatase HUT06_RS31810 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT06_RS31820 ENOG4105CIR epoxide hydrolase HUT06_RS31830 ENOG4107SCK Monooxygenase HUT06_RS31840 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT06_RS31850 ENOG4105C3U ABC transporter HUT06_RS31855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT06_RS31860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS31875 ENOG4106T9R serine protease HUT06_RS31880 ENOG4108WYP Transcriptional regulator HUT06_RS31895 ENOG4105DRR Transcriptional regulator, GntR family HUT06_RS31905 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT06_RS31920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT06_RS31925 ENOG4105CTU Proline racemase HUT06_RS31970 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS31975 ENOG4105EHG Permease protein HUT06_RS31980 ENOG4107R4I Periplasmic binding protein HUT06_RS32010 ENOG4105CPQ Dehydrogenase HUT06_RS32070 ENOG4105DFW ABC transporter HUT06_RS32075 ENOG4105C2J ABC transporter HUT06_RS32080 ENOG4108HWW ABC transporter HUT06_RS32085 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS32105 ENOG4105EF1 ribulokinase HUT06_RS32110 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HUT06_RS32115 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HUT06_RS32120 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS32130 ENOG4105CH2 amidohydrolase HUT06_RS32145 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT06_RS32150 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT06_RS32155 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HUT06_RS32160 ENOG4105EM7 Selenocysteine-specific translation elongation factor HUT06_RS32165 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HUT06_RS32175 ENOG4107RCI amp-dependent synthetase and ligase HUT06_RS32220 ENOG4105DEN Luciferase family HUT06_RS32270 ENOG4105EYF MMPL domain protein HUT06_RS32275 ENOG4108KPJ rna polymerase sigma factor HUT06_RS32285 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT06_RS32295 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT06_RS32300 ENOG4105BZU Histidine kinase HUT06_RS32305 ENOG4105D9P serine threonine protein kinase HUT06_RS32320 ENOG4108YZG isomerase HUT06_RS32335 ENOG4108JJB ABC transporter HUT06_RS32350 ENOG4105MC2 DSBA oxidoreductase HUT06_RS32380 ENOG4105C01 Dihydroxy-acid dehydratase HUT06_RS32425 ENOG4105D8X mechanosensitive ion channel HUT06_RS32435 ENOG4105CG3 alpha amylase, catalytic region HUT06_RS32445 ENOG4105D9U N-acetyltransferase HUT06_RS32480 ENOG4105BZU Histidine kinase HUT06_RS32500 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT06_RS32505 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT06_RS32515 ENOG41081F0 Precorrin-8x methylmutase HUT06_RS32530 ENOG4105D9U N-acetyltransferase HUT06_RS32555 ENOG4105DYW oxidoreductase HUT06_RS32575 ENOG4105BZU Histidine kinase HUT06_RS32580 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS32595 ENOG4105C0B DNA polymerase III (alpha subunit) HUT06_RS32615 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT06_RS32655 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT06_RS32670 ENOG4105D5G Transposase HUT06_RS32700 ENOG4107TPY serine threonine protein kinase HUT06_RS32710 ENOG41061H0 Monooxygenase HUT06_RS32735 ENOG4105ENX hydrolase HUT06_RS32760 ENOG4106NZI LysR family Transcriptional regulator HUT06_RS32770 ENOG4108KPJ rna polymerase sigma factor HUT06_RS32795 ENOG4105ECQ AraC Family Transcriptional Regulator HUT06_RS32845 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT06_RS32850 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT06_RS32855 ENOG4105WBV Transcriptional regulator HUT06_RS32860 ENOG4105D74 hydrolase HUT06_RS32870 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT06_RS32895 ENOG4105EMU Dehydrogenase HUT06_RS32915 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT06_RS32920 ENOG4107QIV Cytochrome c biogenesis protein HUT06_RS32930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT06_RS32935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS32940 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HUT06_RS32945 ENOG4105BZ1 (ABC) transporter HUT06_RS32950 ENOG4105BZ1 (ABC) transporter HUT06_RS32955 ENOG4108MES Periplasmic binding protein HUT06_RS32960 ENOG4105E0A ABC, transporter HUT06_RS32965 ENOG4105TVJ transport system, permease HUT06_RS32970 ENOG4105DQ5 transport system permease protein HUT06_RS32995 ENOG4105DRR Transcriptional regulator, GntR family HUT06_RS33000 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS33005 ENOG4105IIU Aminopeptidase HUT06_RS33010 ENOG4105RFA Lsr2-like protein HUT06_RS33030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS33040 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS33060 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT06_RS33065 ENOG4105E0A ABC, transporter HUT06_RS33070 ENOG4105TVJ transport system, permease HUT06_RS33075 ENOG4105DQ5 transport system permease protein HUT06_RS33110 ENOG4105C32 Amino acid ABC transporter (Permease) HUT06_RS33120 ENOG4108IV0 ABC, transporter HUT06_RS33125 ENOG4105C0Z ABC transporter HUT06_RS33135 ENOG41080UQ Transcriptional regulator HUT06_RS33140 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT06_RS33170 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS33175 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT06_RS33185 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT06_RS33195 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS33215 ENOG4107SCA Formamidase (EC 3.5.1.49) HUT06_RS33220 ENOG4106UDK Cellulose-binding, family II HUT06_RS33400 ENOG410870F Cyclic nucleotide-binding protein HUT06_RS33425 ENOG4108KDT Molybdate metabolism regulator HUT06_RS33470 ENOG4108UVJ appr-1-p processing domain protein HUT06_RS33510 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS33540 ENOG4105D9P serine threonine protein kinase HUT06_RS33600 ENOG4105C3R Methionine synthase HUT06_RS33630 ENOG4105CVR type I restriction-modification system HUT06_RS33705 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HUT06_RS33710 ENOG4105BZ4 penicillin-binding protein HUT06_RS33785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT06_RS33795 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUT06_RS33805 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS33820 ENOG4108VQT Alpha beta hydrolase fold protein HUT06_RS33840 ENOG4106NZI LysR family Transcriptional regulator HUT06_RS33870 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT06_RS33895 ENOG4108UZX fmn reductase HUT06_RS33910 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS33920 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT06_RS33925 ENOG4105E4C Lytic transglycosylase catalytic HUT06_RS33935 ENOG4108SKZ Patatin-like phospholipase HUT06_RS33945 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUT06_RS33950 ENOG4105BZP glycoside hydrolase 15-related HUT06_RS33955 ENOG4105CPQ Dehydrogenase HUT06_RS33970 ENOG4105F0K SARP family transcriptional regulator HUT06_RS34055 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT06_RS34090 ENOG4105DZG Dehydrogenase HUT06_RS34095 ENOG4105SWR response regulator HUT06_RS34100 ENOG4105EBR Carboxylesterase HUT06_RS34110 ENOG4105CC9 acyl-Coa dehydrogenase HUT06_RS34115 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS34120 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS34150 ENOG4105E6M Sulphatase-modifying factor protein HUT06_RS34185 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT06_RS34240 ENOG4105CHU acetyl-coa acetyltransferase HUT06_RS34250 ENOG4108KC2 acyl-Coa dehydrogenase HUT06_RS34260 ENOG4105X7H acyl-CoA dehydrogenase HUT06_RS34265 ENOG4105J5T Amp-dependent synthetase and ligase HUT06_RS34275 ENOG4108IV0 ABC, transporter HUT06_RS34280 ENOG4105C0Z ABC transporter HUT06_RS34285 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT06_RS34295 ENOG4106PGW Short-chain dehydrogenase reductase Sdr HUT06_RS34315 ENOG4107ZR7 Membrane HUT06_RS34340 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT06_RS34345 ENOG4107R13 MMPL domain protein HUT06_RS34365 ENOG4108KPJ rna polymerase sigma factor HUT06_RS34370 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HUT06_RS34385 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS34390 ENOG4105F2C Acetyl-CoA acetyltransferase HUT06_RS34400 ENOG4105CHR reductase HUT06_RS34405 ENOG4108QIU Dehydrogenase HUT06_RS34410 ENOG4105CHR reductase HUT06_RS34415 ENOG4108SGK Tetr family transcriptional regulator HUT06_RS34430 ENOG4108KC1 acyl-Coa dehydrogenase HUT06_RS34465 ENOG4108XG4 DNA-binding transcriptional regulator HUT06_RS34490 ENOG4105J5T Amp-dependent synthetase and ligase HUT06_RS34505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS34515 ENOG4108JQ7 (ABC) transporter HUT06_RS34565 ENOG4105CHR reductase HUT06_RS34580 ENOG4107EFR Flavocytochrome c HUT06_RS34605 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HUT06_RS34610 ENOG41088PD hydrolase HUT06_RS34615 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT06_RS34625 ENOG4105DYW oxidoreductase HUT06_RS34635 ENOG4105BZU Histidine kinase HUT06_RS34665 ENOG4105BZ1 (ABC) transporter HUT06_RS34700 ENOG4105D7V transposase HUT06_RS34710 ENOG4106HK8 GPR1 FUN34 yaaH family protein HUT06_RS34725 ENOG4105DAA L-lactate HUT06_RS34730 ENOG4105C7W Xanthine dehydrogenase HUT06_RS34735 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT06_RS34740 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT06_RS34755 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT06_RS34805 ENOG41060NJ transcriptional regulator HUT06_RS34810 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HUT06_RS34820 ENOG4108IY8 ABC, transporter HUT06_RS34860 ENOG4107S5I aldo keto reductase HUT06_RS34895 ENOG4107TYH extracellular solute-binding protein family 1 HUT06_RS34910 ENOG4105ESN nucleotide-binding protein HUT06_RS34915 ENOG4105ESN nucleotide-binding protein HUT06_RS34920 ENOG4105CSH Transporter HUT06_RS34955 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT06_RS34960 ENOG4108K8K Transcriptional regulator HUT06_RS34970 ENOG4108Q5F Tetr family transcriptional regulator HUT06_RS34975 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT06_RS34990 ENOG4105D5G Transposase HUT06_RS35005 ENOG4105CIK Amidinotransferase HUT06_RS35035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT06_RS35045 ENOG4105F6E Acyl-transferase HUT06_RS35055 ENOG4105C28 cystathionine HUT06_RS35065 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT06_RS35115 ENOG4105CY3 ABC transporter, permease HUT06_RS35130 ENOG4108IG5 Transcriptional regulator HUT06_RS35295 ENOG4105DHJ ABC, transporter HUT06_RS35305 ENOG4107Z3H Transcriptional regulator, TetR family HUT06_RS35315 ENOG4107RN6 Monooxygenase HUT06_RS35320 ENOG41067SE Tetr family transcriptional regulator HUT06_RS35350 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HUT06_RS35360 ENOG4105C6T cysteine synthase HUT06_RS35365 ENOG4105DZP Membrane-associated zinc metalloprotease HUT06_RS35375 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT06_RS35380 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUT06_RS35385 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT06_RS35390 ENOG4105EJQ L-serine dehydratase HUT06_RS35410 ENOG4108Z6Z Transcriptional regulator HUT06_RS35430 ENOG4105F2C Acetyl-CoA acetyltransferase HUT06_RS35450 ENOG4108MRH transcriptional regulatory protein HUT06_RS35455 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT06_RS35485 ENOG4105MPN Membrane HUT06_RS35490 ENOG4105F8D glycoside hydrolase family 4 HUT06_RS35520 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase HUT06_RS35525 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase HUT06_RS35530 ENOG4105C8M UPF0272 protein HUT06_RS35570 ENOG4105BZU Histidine kinase HUT06_RS35590 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS35615 ENOG4105NAF rna polymerase sigma factor HUT06_RS35625 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT06_RS35630 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT06_RS35635 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT06_RS35640 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HUT06_RS35670 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT06_RS35680 ENOG4108RWI nicotinamidase HUT06_RS35685 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT06_RS35705 ENOG4107WAU Protein tyrosine phosphatase HUT06_RS35730 ENOG4108UJU UPF0301 protein HUT06_RS35760 ENOG4105VCH membrane HUT06_RS35770 ENOG4105CHU acetyl-coa acetyltransferase HUT06_RS35785 ENOG4105DSF transport protein HUT06_RS35790 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT06_RS35805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT06_RS35830 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT06_RS35845 ENOG4107XZ0 Peptidase M50 HUT06_RS35875 ENOG4105C26 Dehydrogenase HUT06_RS35945 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT06_RS35950 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT06_RS35955 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT06_RS35960 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT06_RS35965 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT06_RS35970 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT06_RS35975 ENOG4105ZA1 atp synthase HUT06_RS35995 ENOG4105ESV Glycosyl transferase, family 4 HUT06_RS36015 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT06_RS36020 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT06_RS36025 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT06_RS36045 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT06_RS36050 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT06_RS36055 ENOG4105D6E homoserine dehydrogenase HUT06_RS36060 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT06_RS36065 ENOG4105C75 arginyL-tRNA synthetase HUT06_RS36105 ENOG4105E9Z Nad-dependent epimerase dehydratase HUT06_RS36120 ENOG4105BZU Histidine kinase HUT06_RS36145 ENOG4105NPE arsR family transcriptional regulator HUT06_RS36170 ENOG4105EWU Squalene--hopene cyclase HUT06_RS36180 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT06_RS36200 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HUT06_RS36235 ENOG4105JQZ Methyltransferase HUT06_RS36245 ENOG4105G9B Transcriptional regulator HUT06_RS36295 ENOG4105T1M mycothiol conjugate amidase mca HUT06_RS36315 ENOG4105F2Z 3-oxoadipate enol-lactonase HUT06_RS36325 ENOG4107E6A Cytochrome p-450 HUT06_RS36330 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT06_RS36340 ENOG4105MHT Transcriptional regulator, ARSR family HUT06_RS36365 ENOG4105BZ1 (ABC) transporter HUT06_RS36370 ENOG4105C3J Cysteine desulfurase HUT06_RS36380 ENOG4108KGH TRANSCRIPTIONal HUT06_RS36415 ENOG410829K Lysine exporter protein (Lyse ygga) HUT06_RS36420 ENOG4108SGK Tetr family transcriptional regulator HUT06_RS36450 ENOG4105ECP epimerase HUT06_RS36465 ENOG4105F95 Monooxygenase HUT06_RS36575 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS36585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT06_RS36595 ENOG4105CPK Glycosyl transferase (Group 1 HUT06_RS36610 ENOG4105D3Q Sugar transferase HUT06_RS36640 ENOG410719E cytochrome p450 HUT06_RS36645 ENOG4105BZU Histidine kinase HUT06_RS36650 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS36655 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT06_RS36670 ENOG4107TPY serine threonine protein kinase HUT06_RS36685 ENOG4105CRK lysyL-tRNA synthetase HUT06_RS36720 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT06_RS36775 ENOG4105ECB domain protein HUT06_RS36805 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT06_RS36825 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS36850 ENOG4108M6P methyltransferase HUT06_RS36855 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HUT06_RS36860 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT06_RS36865 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT06_RS36875 ENOG4105D2B acyl-CoA dehydrogenase HUT06_RS36885 ENOG4105EXN Sulfate transport protein CysZ HUT06_RS36890 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT06_RS36905 ENOG4105EYW Ion transport protein HUT06_RS36965 ENOG4105C4X radical SAM domain protein HUT06_RS36980 ENOG4107EFR Flavocytochrome c HUT06_RS36985 ENOG41082A2 Alpha beta hydrolase HUT06_RS37000 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT06_RS37005 ENOG4108JQ7 (ABC) transporter HUT06_RS37010 ENOG4105C3U ABC transporter HUT06_RS37015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT06_RS37025 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT06_RS37045 ENOG4105C26 Dehydrogenase HUT06_RS37050 ENOG4105QPS Monooxygenase HUT06_RS37070 ENOG4107SCK Monooxygenase HUT06_RS37090 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT06_RS37095 ENOG4105CN1 protease HUT06_RS37105 ENOG4105CAK Cell division ATP-binding protein ftsE HUT06_RS37120 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT06_RS37130 ENOG4105C7I Dehydrogenase HUT06_RS37150 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT06_RS37160 ENOG4105C26 Dehydrogenase HUT06_RS37170 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HUT06_RS37175 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS37180 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT06_RS37185 ENOG4106KNT transcriptional regulator HUT06_RS37195 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT06_RS37205 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT06_RS37210 ENOG410849S phosphocarrier protein (HPr) HUT06_RS37220 ENOG4105C5Y PTS System HUT06_RS37225 ENOG4105CI1 PTS System HUT06_RS37235 ENOG4105CE4 GlcNAc 6-P deacetylase HUT06_RS37240 ENOG4105FDP GntR family transcriptional regulator HUT06_RS37255 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT06_RS37265 ENOG4105T0Z Conserved Protein HUT06_RS37270 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS37275 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT06_RS37280 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUT06_RS37285 ENOG4105G3P Lipoprotein lpqB HUT06_RS37290 ENOG4105BZU Histidine kinase HUT06_RS37295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS37310 ENOG4108WQ6 secreted protein HUT06_RS37315 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT06_RS37340 ENOG4106R7G Glycoside hydrolase family 5 HUT06_RS37360 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT06_RS37365 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT06_RS37380 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS37385 ENOG4105BZU Histidine kinase HUT06_RS37395 ENOG41086CI Bifunctional phosphoglucose phosphomannose isomerase HUT06_RS37405 ENOG4107QKV phosphomannomutase HUT06_RS37425 ENOG4107RGC Glycosyl transferase, family 2 HUT06_RS37430 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT06_RS37445 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT06_RS37450 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT06_RS37460 ENOG4107RSM transcriptional regulator HUT06_RS37520 ENOG4105VNT transposase (IS4 family) protein HUT06_RS37530 ENOG4105D9P serine threonine protein kinase HUT06_RS37545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT06_RS37555 ENOG4105K63 Thioredoxin HUT06_RS37560 ENOG4107Y2G Glycosyl transferase (Group 1 HUT06_RS37565 ENOG4105CKK Glycosyl transferase, family 2 HUT06_RS37580 ENOG4108KGH TRANSCRIPTIONal HUT06_RS37585 ENOG4108TGC Acyltransferase HUT06_RS37590 ENOG4107SJB teichoic acid biosynthesis HUT06_RS37605 ENOG4105CPK Glycosyl transferase (Group 1 HUT06_RS37630 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUT06_RS37635 ENOG4105CPK Glycosyl transferase (Group 1 HUT06_RS37640 ENOG4107QQG Dehydrogenase HUT06_RS37670 ENOG4108KEZ Dehydrogenase HUT06_RS37675 ENOG4105EEM helicase HUT06_RS37705 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT06_RS37735 ENOG4107TB5 TRANSCRIPTIONal HUT06_RS37760 ENOG4107EDW L-fucose operon activator HUT06_RS37805 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT06_RS37810 ENOG4105K4P CoA-binding domain protein HUT06_RS37815 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HUT06_RS37830 ENOG41065SU Two-component system sensor kinase HUT06_RS37835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS37865 ENOG4108QER Adenylate cyclase HUT06_RS37875 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS37885 ENOG4105CHP RNA polymerase HUT06_RS37890 ENOG4105GRZ Ycii-related protein HUT06_RS37895 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT06_RS37900 ENOG4105D8K carboxyl transferase HUT06_RS37990 ENOG4105EC2 ftsk spoIIIe HUT06_RS38060 ENOG4108JIK carboxylase HUT06_RS38075 ENOG4105ENE Histidine kinase HUT06_RS38080 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS38110 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT06_RS38120 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT06_RS38160 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT06_RS38165 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR HUT06_RS38180 ENOG4105GWZ Roadblock lc7 family protein HUT06_RS38250 ENOG4108JQ9 ABC transporter HUT06_RS38255 ENOG4105DIH basic membrane HUT06_RS38260 ENOG4107RM1 amidohydrolase HUT06_RS38265 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HUT06_RS38275 ENOG4107S2Z UPF0761 membrane protein HUT06_RS38285 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT06_RS38295 ENOG4105CMR udp-glucose 4-epimerase HUT06_RS38300 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT06_RS38310 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT06_RS38370 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT06_RS38380 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUT06_RS38400 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT06_RS38415 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT06_RS38440 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT06_RS38455 ENOG4105D9U N-acetyltransferase HUT06_RS38490 ENOG4108UTZ Dihydroxyacetone kinase HUT06_RS38495 ENOG4105CMT Dihydroxyacetone kinase HUT06_RS38500 ENOG4105DU0 nucleoside hydrolase HUT06_RS38525 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS38575 ENOG4108KQJ Type 11 methyltransferase HUT06_RS38580 ENOG4107SJB teichoic acid biosynthesis HUT06_RS38585 ENOG4107SJB teichoic acid biosynthesis HUT06_RS38610 ENOG4105ECP epimerase HUT06_RS38615 ENOG4105D3R alkyl hydroperoxide reductase HUT06_RS38620 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT06_RS38625 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT06_RS38650 ENOG4105C26 Dehydrogenase HUT06_RS38655 ENOG4108IG5 Transcriptional regulator HUT06_RS38660 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT06_RS38665 ENOG4107QVP Dehydrogenase HUT06_RS38685 ENOG4108MMM RNA Polymerase HUT06_RS38690 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT06_RS38695 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT06_RS38715 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT06_RS38735 ENOG4108097 ATP-binding protein HUT06_RS38740 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT06_RS38745 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT06_RS38780 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT06_RS38785 ENOG4105CS9 pantothenic acid kinase HUT06_RS38795 ENOG4108KDT Molybdate metabolism regulator HUT06_RS38805 ENOG4108ZGX Histidine kinase HUT06_RS38810 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS38820 ENOG4105CJ1 ABC, transporter HUT06_RS38830 ENOG4105DA5 (ABC) transporter HUT06_RS38850 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT06_RS38855 ENOG4108UJD 30S ribosomal protein S9 HUT06_RS38860 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT06_RS38865 ENOG4105K4I Scp-like extracellular HUT06_RS38880 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT06_RS38885 ENOG4108ZT0 50S ribosomal protein l17 HUT06_RS38890 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT06_RS38895 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT06_RS38900 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT06_RS38905 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT06_RS38910 ENOG41067V7 50S ribosomal protein L36 HUT06_RS38915 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT06_RS38930 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HUT06_RS38945 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT06_RS38950 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUT06_RS38955 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT06_RS38965 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT06_RS38970 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT06_RS38975 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT06_RS38980 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT06_RS38985 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT06_RS38990 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT06_RS38995 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT06_RS39000 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT06_RS39005 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT06_RS39010 ENOG41082SA 50s ribosomal protein l29 HUT06_RS39015 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT06_RS39020 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT06_RS39025 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT06_RS39030 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT06_RS39035 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT06_RS39040 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT06_RS39045 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT06_RS39050 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT06_RS39055 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT06_RS39060 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT06_RS39065 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT06_RS39070 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT06_RS39075 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT06_RS39090 ENOG4105CPC Aldo Keto reductase HUT06_RS39145 ENOG4105EMN RNA polymerase sigma factor HUT06_RS39170 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS39250 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT06_RS39260 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT06_RS39265 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT06_RS39315 ENOG4105CY3 ABC transporter, permease HUT06_RS39325 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT06_RS39330 ENOG4108VZM 50s ribosomal protein L10 HUT06_RS39340 ENOG4105QCJ Lipoprotein HUT06_RS39365 ENOG4105PF9 Transcriptional regulator HUT06_RS39375 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT06_RS39380 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT06_RS39410 ENOG4105NAF rna polymerase sigma factor HUT06_RS39430 ENOG4105DRR Transcriptional regulator, GntR family HUT06_RS39435 ENOG4107R4N Cell wall formation (By similarity) HUT06_RS39445 ENOG410900P UPF0336 protein HUT06_RS39450 ENOG4105WDJ 50S ribosomal protein L33 HUT06_RS39465 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS39575 ENOG4105CNU cell division protein FtsK HUT06_RS39600 ENOG4108VPT UPF0234 protein HUT06_RS39605 ENOG4105D0M Protease HtpX homolog HUT06_RS39610 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39615 ENOG4105C8S subunit m HUT06_RS39620 ENOG4105D65 subunit l HUT06_RS39625 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39635 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39645 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT06_RS39650 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT06_RS39655 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39660 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT06_RS39675 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT06_RS39680 ENOG4105DQU oxidoreductase, subunit beta HUT06_RS39755 ENOG4105JZI cytochrome P450 HUT06_RS39790 ENOG4106NZI LysR family Transcriptional regulator HUT06_RS39795 ENOG4105F27 Major Facilitator HUT06_RS39805 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39815 ENOG4105D65 subunit l HUT06_RS39825 ENOG4105DF2 NADH dehydrogenase subunit j HUT06_RS39830 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39835 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT06_RS39840 ENOG4108IEH NADH dehydrogenase subunit g HUT06_RS39855 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39860 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT06_RS39865 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS39880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT06_RS39890 ENOG4105C7B Threonine dehydratase HUT06_RS39910 ENOG4105CRE cytochrome C HUT06_RS39915 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HUT06_RS39920 ENOG4107QIV Cytochrome c biogenesis protein HUT06_RS39930 ENOG4108RH7 phosphoglycerate mutase HUT06_RS39945 ENOG4108594 Permease of the drug metabolite transporter HUT06_RS39950 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT06_RS39955 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT06_RS39960 ENOG4105D9P serine threonine protein kinase HUT06_RS39970 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT06_RS39975 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT06_RS39980 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT06_RS39985 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT06_RS39990 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT06_RS40015 ENOG4108RXW HAD-superfamily subfamily IB hydrolase HUT06_RS40040 ENOG4105I6B RNA polymerase HUT06_RS40100 ENOG4108KPJ rna polymerase sigma factor HUT06_RS40125 ENOG4108XFF HUT06_RS40130 ENOG4105DGU Histone deacetylase HUT06_RS40150 ENOG4105II7 pyrroline-5-carboxylate reductase HUT06_RS40160 ENOG4108KGH TRANSCRIPTIONal HUT06_RS40170 ENOG4105CIG ABC transporter HUT06_RS40180 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT06_RS40185 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HUT06_RS40195 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUT06_RS40200 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT06_RS40225 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT06_RS40270 ENOG4105ETE Transcriptional regulator (LacI family HUT06_RS40280 ENOG4105CRK lysyL-tRNA synthetase HUT06_RS40285 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT06_RS40295 ENOG4108IYU L-aspartate oxidase HUT06_RS40300 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT06_RS40305 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT06_RS40315 ENOG4107R34 abc transporter permease protein HUT06_RS40320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS40330 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS40335 ENOG4105BZU Histidine kinase HUT06_RS40340 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT06_RS40345 ENOG4106A3M Cytochrome p-450 HUT06_RS40370 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT06_RS40380 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUT06_RS40400 ENOG4105EUJ GTP cyclohydrolase i HUT06_RS40410 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUT06_RS40415 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT06_RS40430 ENOG4105F0N pyrophosphate phospho-hydrolase HUT06_RS40435 ENOG4105ZXU NLP P60 protein HUT06_RS40470 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUT06_RS40480 ENOG4108M1A Chitin-binding protein HUT06_RS40650 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT06_RS40690 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS40715 ENOG4105C7K acetolactate synthase HUT06_RS40850 ENOG4107XI7 Tetr family transcriptional regulator HUT06_RS40860 ENOG4108MUZ hydrolase HUT06_RS40890 ENOG4105D74 hydrolase HUT06_RS40910 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT06_RS40930 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT06_RS40940 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT06_RS40985 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT06_RS41010 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT06_RS41025 ENOG4107QIK phosphoribosylformylglycinamidine synthase HUT06_RS41030 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT06_RS41040 ENOG410839H phosphoribosylformylglycinamidine synthase HUT06_RS41050 ENOG4105CHP RNA polymerase HUT06_RS41055 ENOG4105GRZ Ycii-related protein HUT06_RS41095 ENOG4105CPP Dehydrogenase, E1 component HUT06_RS41100 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT06_RS41195 ENOG4105CSU acyl-Coa dehydrogenase HUT06_RS41200 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT06_RS41205 ENOG4105KPY Small multidrug resistance protein HUT06_RS41220 ENOG4105EMU Dehydrogenase HUT06_RS41235 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT06_RS41275 ENOG4107XDR Lactoylglutathione lyase HUT06_RS41285 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS41300 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT06_RS41310 ENOG4105CHP RNA polymerase HUT06_RS41320 ENOG4105EYF MMPL domain protein HUT06_RS41325 ENOG4108KPJ rna polymerase sigma factor HUT06_RS41370 ENOG4105BZU Histidine kinase HUT06_RS41375 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUT06_RS41390 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS41395 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS41400 ENOG4105EB3 Histidine kinase HUT06_RS41405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT06_RS41420 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT06_RS41480 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT06_RS41495 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS41525 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT06_RS41545 ENOG4105WN5 stage II sporulation protein HUT06_RS41585 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS41605 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT06_RS41640 ENOG4105D9P serine threonine protein kinase HUT06_RS41655 ENOG4108V8F Transcriptional regulator, MarR family HUT06_RS41675 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT06_RS41695 ENOG4108JQ1 Dehydrogenase HUT06_RS41710 ENOG4105C1G acyl-Coa dehydrogenase HUT06_RS41730 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT06_RS41735 ENOG4105CPF Cell wall formation (By similarity) HUT06_RS41740 ENOG4106F60 Histidine kinase HUT06_RS41800 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT06_RS41805 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT06_RS41830 ENOG4105EYF MMPL domain protein HUT06_RS41835 ENOG4108SGK Tetr family transcriptional regulator HUT06_RS41845 ENOG4105W1N transcriptional regulator HUT06_RS41880 ENOG4105CEY Amp-dependent synthetase and ligase HUT06_RS41905 ENOG4107R13 MMPL domain protein HUT06_RS41915 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS41925 ENOG4105E39 Enoyl-CoA hydratase HUT06_RS41945 ENOG4105DU6 RNA polymerase HUT06_RS41950 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT06_RS41990 ENOG4108YYC ycei family HUT06_RS41995 ENOG4106F60 Histidine kinase HUT06_RS42005 ENOG4108PYU two-component system response regulator HUT06_RS42010 ENOG4105EB3 Histidine kinase HUT06_RS42025 ENOG4107EJG GntR family transcriptional regulator HUT06_RS42050 ENOG4105NAF rna polymerase sigma factor HUT06_RS42075 ENOG4105N14 lysine exporter protein LysE YggA HUT06_RS42080 ENOG4105F7P transcriptional regulator AsnC family HUT06_RS42105 ENOG4105BZU Histidine kinase HUT06_RS42160 ENOG4105F27 Major Facilitator HUT06_RS42165 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT06_RS42170 ENOG4108ZT1 Transcriptional regulator HUT06_RS42200 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT06_RS42210 ENOG4107R13 MMPL domain protein HUT06_RS42215 ENOG4107RCI amp-dependent synthetase and ligase HUT06_RS42250 ENOG4105K6T rare lipoprotein A HUT06_RS42270 ENOG4108SGK Tetr family transcriptional regulator HUT06_RS42305 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT06_RS42335 ENOG4105ECQ AraC Family Transcriptional Regulator HUT06_RS42340 ENOG41082W1 Cupin 2, conserved barrel domain protein HUT06_RS42355 ENOG4105FBW Monooxygenase HUT06_RS42380 ENOG4107QY8 reductase HUT06_RS42400 ENOG4105DKW ABC transporter HUT06_RS42420 ENOG4105D7V transposase HUT06_RS42430 ENOG4105WH1 Two component transcriptional regulator luxr family HUT06_RS42440 ENOG4105CHR reductase HUT06_RS42450 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HUT06_RS42455 ENOG4105EAC phosphoserine phosphatase HUT06_RS42475 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT06_RS42480 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT06_RS42485 ENOG4105WN5 stage II sporulation protein HUT06_RS42490 ENOG4108I5C dEAD DEAH box helicase HUT06_RS42565 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT06_RS42570 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT06_RS42580 ENOG4105D74 hydrolase HUT06_RS42590 ENOG4105C0H protease HUT06_RS42595 ENOG4105P8F nudix hydrolase HUT06_RS42615 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT06_RS42635 ENOG4105IJJ transcriptional regulator, crp fnr family HUT06_RS42640 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT06_RS42665 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT06_RS42700 ENOG4105BZ4 penicillin-binding protein HUT06_RS42715 ENOG4108YRB methyltransferase HUT06_RS42725 ENOG41085W3 Transposase HUT06_RS42760 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUT06_RS42845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT06_RS42885 ENOG4105GFR rna polymerase sigma factor HUT06_RS42890 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUT06_RS42955 ENOG4107R4Z monovalent cation h antiporter subunit d HUT06_RS43005 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT06_RS43015 ENOG4105CH6 catalase HUT06_RS43035 ENOG4107RCH Diaminopropionate ammonia-lyase HUT06_RS43040 ENOG4105VP0 transcriptional regulator, lysR family HUT06_RS43075 ENOG41067SE Tetr family transcriptional regulator HUT06_RS43085 ENOG4105CFH Aspartokinase HUT06_RS43105 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT06_RS43110 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT06_RS43115 ENOG4108UW5 maltose o-acetyltransferase HUT06_RS43155 ENOG4105DJ2 Major Facilitator Superfamily HUT06_RS43160 ENOG4105JXH GntR family transcriptional regulator HUT06_RS43185 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT06_RS43210 ENOG4108Z6B deaminase HUT06_RS43240 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT06_RS43285 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT06_RS43310 ENOG4108VHT MarR family transcriptional regulator HUT06_RS43330 ENOG4108IG5 Transcriptional regulator HUT06_RS43335 ENOG4105EYF MMPL domain protein HUT06_RS43350 ENOG4108IG5 Transcriptional regulator HUT06_RS43395 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT06_RS43400 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT06_RS43405 ENOG4107YH6 single-stranded DNA-binding protein HUT06_RS43410 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT06_RS43425 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT06_RS43440 ENOG4105W1Y Transcriptional regulator HUT06_RS43450 ENOG4105BZ4 penicillin-binding protein HUT06_RS43455 ENOG4105BZ4 penicillin-binding protein HUT06_RS43470 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT06_RS43490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT06_RS43495 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT06_RS43515 ENOG4105D9P serine threonine protein kinase HUT06_RS43535 ENOG4105C3M thioredoxin reductase HUT06_RS43540 ENOG4105K63 Thioredoxin HUT06_RS43550 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT06_RS43555 ENOG4105CPF Cell wall formation (By similarity) HUT06_RS43570 ENOG4107QJE Chromosome Partitioning Protein HUT06_RS43575 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT06_RS43595 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT06_RS43600 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT06_RS43605 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HUT06_RS43610 ENOG41084CH 50S ribosomal protein l34