locus-tag	class	description
I6I08_RS00045	COG1309	transcriptional regulator
I6I08_RS00060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I08_RS00095	COG1136	(ABC) transporter
I6I08_RS00115	COG0148	phosphopyruvate hydratase activity
I6I08_RS00150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I08_RS00155	COG0193	aminoacyl-tRNA hydrolase activity
I6I08_RS00160	COG2197	response regulator
I6I08_RS00165	COG4585	Histidine kinase
I6I08_RS00195	COG0444	Belongs to the ABC transporter superfamily
I6I08_RS00200	COG1124	(ABC) transporter
I6I08_RS00210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I08_RS00230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I08_RS00235	COG0431	NADPH-dependent FMN reductase
I6I08_RS00270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I08_RS00275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I08_RS00285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I08_RS00295	COG3265	gluconokinase activity
I6I08_RS00305	COG0513	Belongs to the DEAD box helicase family
I6I08_RS00360	COG0791	NLP P60 protein
I6I08_RS00565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I08_RS00570	COG0494	nUDIX hydrolase
I6I08_RS00570	COG0406	alpha-ribazole phosphatase activity
I6I08_RS00595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I08_RS00600	COG0745	RESPONSE REGULATOR receiver
I6I08_RS00610	COG3485	protocatechuate 3,4-dioxygenase
I6I08_RS00615	COG0354	folic acid binding
I6I08_RS00625	COG1490	D-aminoacyl-tRNA deacylase activity
I6I08_RS00635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I08_RS00680	COG0745	RESPONSE REGULATOR receiver
I6I08_RS00685	COG2205	protein histidine kinase activity
I6I08_RS00690	COG2132	Multicopper oxidase
I6I08_RS00740	COG0297	glycogen (starch) synthase activity
I6I08_RS00740	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS00750	COG2211	Major facilitator Superfamily
I6I08_RS00760	COG0574	Belongs to the PEP-utilizing enzyme family
I6I08_RS00760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I08_RS00770	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I08_RS00785	COG0477	Major facilitator Superfamily
I6I08_RS00785	COG2814	Major facilitator Superfamily
I6I08_RS00790	COG3119	arylsulfatase activity
I6I08_RS00795	COG1940	carbohydrate kinase activity
I6I08_RS00800	COG0641	radical SAM
I6I08_RS00805	COG0730	response to heat
I6I08_RS00820	COG0698	ribose 5-phosphate isomerase
I6I08_RS00935	COG1362	aminopeptidase activity
I6I08_RS00940	COG3012	SEC-C Motif Domain Protein
I6I08_RS00945	COG0604	alcohol dehydrogenase
I6I08_RS00950	COG1733	regulation of RNA biosynthetic process
I6I08_RS00955	COG1902	pentaerythritol trinitrate reductase activity
I6I08_RS00970	COG2267	carboxylic ester hydrolase activity
I6I08_RS00980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I08_RS00990	COG0601	transmembrane transport
I6I08_RS00995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I08_RS01035	COG1217	gtp-binding protein TYPA
I6I08_RS01075	COG2814	Major facilitator Superfamily
I6I08_RS01090	COG3415	Transposase
I6I08_RS01090	COG2801	Transposase and inactivated derivatives
I6I08_RS01100	COG1053	succinate dehydrogenase
I6I08_RS01110	COG2171	N-acyltransferase activity
I6I08_RS01115	COG0406	alpha-ribazole phosphatase activity
I6I08_RS01135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I08_RS01140	COG1397	ADP-ribosylglycohydrolase
I6I08_RS01155	COG3477	response to acidic pH
I6I08_RS01180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I08_RS01185	COG2197	response regulator
I6I08_RS01200	COG2235	arginine
I6I08_RS01205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I08_RS01210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I08_RS01215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I08_RS01220	COG0395	ABC-type sugar transport system, permease component
I6I08_RS01225	COG1175	transmembrane transport
I6I08_RS01235	COG5426	von Willebrand factor, type A
I6I08_RS01240	COG1940	carbohydrate kinase activity
I6I08_RS01250	COG4176	ABC-type proline glycine betaine transport system permease component
I6I08_RS01270	COG4948	Mandelate Racemase Muconate Lactonizing
I6I08_RS01275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I08_RS01280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I08_RS01295	COG1169	isochorismate synthase
I6I08_RS01300	COG2226	methyltransferase
I6I08_RS01305	COG0644	oxidoreductase
I6I08_RS01315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I08_RS01320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I08_RS01325	COG0649	NAD binding
I6I08_RS01335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I08_RS01345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I08_RS01360	COG0713	ATP synthesis coupled electron transport
I6I08_RS01365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I08_RS01375	COG1007	ATP synthesis coupled electron transport
I6I08_RS01380	COG0142	geranyltranstransferase activity
I6I08_RS01385	COG2885	chlorophyll binding
I6I08_RS01405	COG0501	Belongs to the peptidase M48B family
I6I08_RS01425	COG2197	response regulator
I6I08_RS01430	COG1666	GTP binding
I6I08_RS01450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I08_RS01465	COG0424	maF-like protein
I6I08_RS01480	COG0745	RESPONSE REGULATOR receiver
I6I08_RS01485	COG5002	protein histidine kinase activity
I6I08_RS01515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I08_RS01520	COG1316	TRANSCRIPTIONal
I6I08_RS01545	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS01550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I08_RS01570	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS01585	COG0297	glycogen (starch) synthase activity
I6I08_RS01600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I08_RS01615	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I08_RS01630	COG0463	Glycosyl transferase, family 2
I6I08_RS01685	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS01690	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS01715	COG1482	cell wall glycoprotein biosynthetic process
I6I08_RS01750	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I08_RS01765	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I6I08_RS01770	COG0714	Associated with various cellular activities
I6I08_RS01790	COG0745	RESPONSE REGULATOR receiver
I6I08_RS01795	COG5000	phosphorelay sensor kinase activity
I6I08_RS01795	COG5002	protein histidine kinase activity
I6I08_RS01800	COG5401	PFAM Sporulation and spore germination
I6I08_RS01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I08_RS01815	COG0653	protein targeting
I6I08_RS01855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I08_RS01860	COG0222	ribosome binding
I6I08_RS01870	COG0085	RNA polymerase activity
I6I08_RS01875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I08_RS01905	COG0419	ATPase involved in DNA repair
I6I08_RS01910	COG0420	3'-5' exonuclease activity
I6I08_RS01940	COG1968	undecaprenyl-diphosphatase activity
I6I08_RS01950	COG0483	inositol monophosphate 1-phosphatase activity
I6I08_RS01955	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I08_RS01960	COG0456	acetyltransferase
I6I08_RS01965	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I08_RS01990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I08_RS02015	COG1140	nitrate reductase beta subunit
I6I08_RS02030	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I08_RS02030	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I08_RS02040	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I08_RS02050	COG0314	molybdopterin synthase activity
I6I08_RS02060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I08_RS02090	COG1162	GTPase activity
I6I08_RS02095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I08_RS02105	COG2838	Isocitrate dehydrogenase
I6I08_RS02115	COG1595	DNA-templated transcription, initiation
I6I08_RS02135	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I08_RS02135	COG0567	Dehydrogenase, E1 component
I6I08_RS02145	COG1253	flavin adenine dinucleotide binding
I6I08_RS02155	COG0739	heme binding
I6I08_RS02170	COG0018	arginyl-trna synthetase
I6I08_RS02175	COG0019	diaminopimelate decarboxylase activity
I6I08_RS02190	COG0460	homoserine dehydrogenase
I6I08_RS02195	COG0083	homoserine kinase activity
I6I08_RS02200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I08_RS02205	COG0431	NADPH-dependent FMN reductase
I6I08_RS02215	COG0254	rRNA binding
I6I08_RS02220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I08_RS02240	COG1846	Transcriptional regulator
I6I08_RS02245	COG4221	oxidoreductase activity
I6I08_RS02245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I08_RS02245	COG3321	synthase
I6I08_RS02245	COG0604	alcohol dehydrogenase
I6I08_RS02255	COG0693	protein deglycase activity
I6I08_RS02275	COG0110	maltose O-acetyltransferase activity
I6I08_RS02280	COG1501	Belongs to the glycosyl hydrolase 31 family
I6I08_RS02285	COG0366	Alpha amylase catalytic
I6I08_RS02310	COG0205	6-phosphofructokinase activity
I6I08_RS02320	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I08_RS02355	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I08_RS02360	COG1132	(ABC) transporter
I6I08_RS02365	COG4988	ABC transporter
I6I08_RS02370	COG0039	L-malate dehydrogenase activity
I6I08_RS02380	COG1175	transmembrane transport
I6I08_RS02385	COG0395	ABC-type sugar transport system, permease component
I6I08_RS02420	COG0058	SHG alpha-glucan phosphorylase activity
I6I08_RS02425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I08_RS02430	COG3281	Trehalose synthase
I6I08_RS02440	COG0366	Alpha amylase catalytic
I6I08_RS02465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I08_RS02475	COG0482	sulfurtransferase activity
I6I08_RS02510	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I08_RS02525	COG1615	UPF0182 protein
I6I08_RS02535	COG2326	polyphosphate kinase activity
I6I08_RS02540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I08_RS02610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I08_RS02620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I08_RS02655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I08_RS02660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I08_RS02670	COG2190	(PTS) system
I6I08_RS02675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I08_RS02680	COG2188	Transcriptional regulator
I6I08_RS02685	COG1263	PTS System
I6I08_RS02710	COG3590	peptidase
I6I08_RS02715	COG0698	ribose 5-phosphate isomerase
I6I08_RS02730	COG1045	serine acetyltransferase
I6I08_RS02740	COG1739	Uncharacterized protein family UPF0029
I6I08_RS02760	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I08_RS02780	COG0740	serine-type endopeptidase activity
I6I08_RS02785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I08_RS02790	COG0287	Prephenate dehydrogenase
I6I08_RS02790	COG1605	Chorismate mutase
I6I08_RS02805	COG1653	transport
I6I08_RS02820	COG0366	Alpha amylase catalytic
I6I08_RS02825	COG1609	Transcriptional regulator
I6I08_RS02840	COG1222	aaa ATPase
I6I08_RS02845	COG4122	O-methyltransferase activity
I6I08_RS02855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6I08_RS02865	COG1122	ATPase activity
I6I08_RS02870	COG1132	(ABC) transporter
I6I08_RS02870	COG2375	cellular response to nickel ion
I6I08_RS02900	COG0730	response to heat
I6I08_RS02905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I08_RS02905	COG1648	precorrin-2 dehydrogenase activity
I6I08_RS02920	COG0175	sulfate reduction
I6I08_RS02925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I08_RS02930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I08_RS02935	COG2056	Na+-H+ antiporter family
I6I08_RS02940	COG4221	oxidoreductase activity
I6I08_RS02950	COG0656	L-ascorbic acid biosynthetic process
I6I08_RS02975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I08_RS02980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I08_RS02985	COG1215	transferase activity, transferring glycosyl groups
I6I08_RS02990	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS03020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I08_RS03025	COG0285	dihydrofolate synthase activity
I6I08_RS03030	COG1461	Dihydroxyacetone kinase
I6I08_RS03035	COG0105	UTP biosynthetic process
I6I08_RS03045	COG4152	abc transporter atp-binding protein
I6I08_RS03050	COG1196	nuclear chromosome segregation
I6I08_RS03065	COG2197	response regulator
I6I08_RS03070	COG4585	Histidine kinase
I6I08_RS03075	COG0842	Transport permease protein
I6I08_RS03080	COG1131	(ABC) transporter
I6I08_RS03090	COG2197	response regulator
I6I08_RS03095	COG4585	Histidine kinase
I6I08_RS03120	COG1837	Belongs to the UPF0109 family
I6I08_RS03125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I08_RS03130	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I08_RS03135	COG0681	Belongs to the peptidase S26 family
I6I08_RS03145	COG0681	Belongs to the peptidase S26 family
I6I08_RS03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I08_RS03160	COG0792	nuclease activity
I6I08_RS03180	COG1716	ATPase activity
I6I08_RS03190	COG4974	Belongs to the 'phage' integrase family
I6I08_RS03200	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I08_RS03205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I08_RS03215	COG0233	cytoplasmic translational termination
I6I08_RS03225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I08_RS03235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I08_RS03240	COG0750	zinc metalloprotease
I6I08_RS03245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I08_RS03250	COG0456	acetyltransferase
I6I08_RS03250	COG0454	-acetyltransferase
I6I08_RS03285	COG0442	prolyl-tRNA aminoacylation
I6I08_RS03320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I08_RS03320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I08_RS03340	COG0330	HflC and HflK could
I6I08_RS03350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I08_RS03355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I08_RS03365	COG0577	efflux transmembrane transporter activity
I6I08_RS03365	COG1136	(ABC) transporter
I6I08_RS03375	COG0196	riboflavin kinase activity
I6I08_RS03385	COG1454	alcohol dehydrogenase
I6I08_RS03390	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I08_RS03395	COG0612	Peptidase, M16
I6I08_RS03400	COG0300	oxidoreductase activity
I6I08_RS03405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I08_RS03425	COG0318	PFAM AMP-dependent synthetase and ligase
I6I08_RS03430	COG0318	PFAM AMP-dependent synthetase and ligase
I6I08_RS03450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I08_RS03460	COG2001	Belongs to the MraZ family
I6I08_RS03465	COG0275	rRNA processing
I6I08_RS03475	COG0768	penicillin binding
I6I08_RS03480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I08_RS03485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I08_RS03490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I08_RS03495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I08_RS03510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I08_RS03520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I08_RS03525	COG1496	oxidoreductase activity
I6I08_RS03530	COG1799	cell septum assembly
I6I08_RS03540	COG3599	regulation of cell shape
I6I08_RS03545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I08_RS03560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I08_RS03565	COG0587	DNA-directed DNA polymerase activity
I6I08_RS03570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I08_RS03575	COG2501	S4 domain
I6I08_RS03595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I08_RS03600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I08_RS03610	COG1215	transferase activity, transferring glycosyl groups
I6I08_RS03620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I08_RS03635	COG0514	ATP-dependent DNA helicase (RecQ)
I6I08_RS03640	COG1846	Transcriptional regulator
I6I08_RS03645	COG0025	NhaP-type Na H and K H
I6I08_RS03655	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I08_RS03670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I08_RS03675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I08_RS03690	COG1131	(ABC) transporter
I6I08_RS03700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I08_RS03705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I08_RS03710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I08_RS03725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I08_RS03740	COG1126	abc transporter atp-binding protein
I6I08_RS03745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I08_RS03750	COG0765	amino acid transport
I6I08_RS03755	COG0765	amino acid transport
I6I08_RS03785	COG1131	(ABC) transporter
I6I08_RS03810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I08_RS03820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I08_RS03825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I08_RS03830	COG1438	arginine binding
I6I08_RS03835	COG0137	argininosuccinate synthase activity
I6I08_RS03840	COG2116	formate transmembrane transporter activity
I6I08_RS03845	COG0165	Argininosuccinate lyase
I6I08_RS03850	COG2094	Belongs to the DNA glycosylase MPG family
I6I08_RS03870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I08_RS03900	COG0647	UMP catabolic process
I6I08_RS03915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I08_RS03920	COG0497	DNA recombination
I6I08_RS03950	COG0494	nUDIX hydrolase
I6I08_RS03955	COG1609	Transcriptional regulator
I6I08_RS03965	COG1175	transmembrane transport
I6I08_RS03970	COG0395	ABC-type sugar transport system, permease component
I6I08_RS03995	COG0719	Fe-S assembly protein
I6I08_RS04000	COG0396	ATPase activity
I6I08_RS04010	COG0822	iron-sulfur transferase activity
I6I08_RS04015	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I08_RS04020	COG3189	MarR family transcriptional regulator
I6I08_RS04035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I08_RS04050	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I08_RS04070	COG0167	dihydroorotate dehydrogenase activity
I6I08_RS04090	COG1609	Transcriptional regulator
I6I08_RS04095	COG3833	ABC-type maltose transport systems, permease component
I6I08_RS04100	COG1175	transmembrane transport
I6I08_RS04105	COG2182	Extracellular solute-binding protein
I6I08_RS04120	COG0358	DNA primase activity
I6I08_RS04150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I08_RS04160	COG1027	Aspartate ammonia-lyase
I6I08_RS04170	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I08_RS04200	COG0436	Aminotransferase
I6I08_RS04385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I08_RS04425	COG0515	serine threonine protein kinase
I6I08_RS04425	COG2815	serine threonine protein kinase
I6I08_RS04490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I08_RS04500	COG3022	response to hydroperoxide
I6I08_RS04520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I08_RS04525	COG0174	glutamine synthetase
I6I08_RS04530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I08_RS04535	COG0406	alpha-ribazole phosphatase activity
I6I08_RS04545	COG0765	amino acid transport
I6I08_RS04565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I08_RS04570	COG0321	lipoyl(octanoyl) transferase activity
I6I08_RS04600	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I08_RS04605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I08_RS04610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I08_RS04620	COG0038	chloride channel
I6I08_RS04625	COG1073	alpha beta
I6I08_RS04635	COG1882	Formate acetyltransferase
I6I08_RS04695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I08_RS04715	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS04730	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6I08_RS04735	COG1051	belongs to the nudix hydrolase family
I6I08_RS04740	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6I08_RS04745	COG0217	transcriptional regulatory protein
I6I08_RS04750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I08_RS04755	COG0632	four-way junction helicase activity
I6I08_RS04760	COG2255	four-way junction helicase activity
I6I08_RS04770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I08_RS04775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I08_RS04780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I08_RS04785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I08_RS04795	COG0789	Transcriptional regulator
I6I08_RS04800	COG1196	nuclear chromosome segregation
I6I08_RS04805	COG0488	(ABC) transporter
I6I08_RS04815	COG0124	histidyl-tRNA synthetase
I6I08_RS04845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I08_RS04845	COG1116	anion transmembrane transporter activity
I6I08_RS04875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I08_RS04905	COG0009	L-threonylcarbamoyladenylate synthase
I6I08_RS04915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I08_RS04920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I08_RS04925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I08_RS04935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I08_RS04940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I08_RS04945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I08_RS04950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I08_RS04955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I08_RS04960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I08_RS04985	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6I08_RS04990	COG0540	Belongs to the ATCase OTCase family
I6I08_RS04995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I08_RS05005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I08_RS05010	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I08_RS05020	COG0194	GDP metabolic process
I6I08_RS05025	COG1758	RNA polymerase activity
I6I08_RS05035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I08_RS05065	COG0549	Belongs to the carbamate kinase family
I6I08_RS05070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I08_RS05085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I08_RS05095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I08_RS05100	COG4770	biotin carboxylase activity
I6I08_RS05105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I08_RS05110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I08_RS05115	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I08_RS05120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I08_RS05125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I08_RS05130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I08_RS05135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I08_RS05140	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I08_RS05160	COG1131	(ABC) transporter
I6I08_RS05165	COG2197	response regulator
I6I08_RS05170	COG4585	Histidine kinase
I6I08_RS05190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I08_RS05195	COG0805	protein transport
I6I08_RS05210	COG2354	Protein conserved in bacteria
I6I08_RS05215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I08_RS05220	COG1216	Glycosyl transferase, family 2
I6I08_RS05230	COG0205	6-phosphofructokinase activity
I6I08_RS05245	COG0577	efflux transmembrane transporter activity
I6I08_RS05250	COG1136	(ABC) transporter
I6I08_RS05260	COG1609	Transcriptional regulator
I6I08_RS05265	COG2190	(PTS) system
I6I08_RS05265	COG1263	PTS System
I6I08_RS05265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I08_RS05270	COG1621	beta-fructofuranosidase activity
I6I08_RS05285	COG0443	Heat shock 70 kDa protein
I6I08_RS05290	COG0667	Aldo Keto reductase
I6I08_RS05310	COG1716	ATPase activity
I6I08_RS05320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I08_RS05335	COG0363	glucosamine-6-phosphate deaminase activity
I6I08_RS05365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I08_RS05370	COG0166	Belongs to the GPI family
I6I08_RS05390	COG1160	GTP binding
I6I08_RS05405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I08_RS05425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I08_RS05430	COG0149	triose-phosphate isomerase activity
I6I08_RS05435	COG0126	phosphoglycerate kinase activity
I6I08_RS05440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I08_RS05445	COG1481	regulation of sporulation
I6I08_RS05455	COG1660	Displays ATPase and GTPase activities
I6I08_RS05460	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I08_RS05470	COG2190	(PTS) system
I6I08_RS05470	COG1263	PTS System
I6I08_RS05470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I08_RS05480	COG3585	molybdate ion transport
I6I08_RS05485	COG0322	excinuclease ABC activity
I6I08_RS05490	COG0561	phosphatase activity
I6I08_RS05550	COG0556	nucleotide-excision repair
I6I08_RS05560	COG0237	dephospho-CoA kinase activity
I6I08_RS05570	COG0539	negative regulation of cytoplasmic translation
I6I08_RS05580	COG2050	protein possibly involved in aromatic compounds catabolism
I6I08_RS05610	COG0134	indole-3-glycerol-phosphate synthase activity
I6I08_RS05630	COG0107	imidazoleglycerol-phosphate synthase activity
I6I08_RS05640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6I08_RS05650	COG4122	O-methyltransferase activity
I6I08_RS05655	COG1222	aaa ATPase
I6I08_RS05670	COG2837	iron assimilation
I6I08_RS05675	COG0517	IMP dehydrogenase activity
I6I08_RS05675	COG1994	Peptidase M50
I6I08_RS05685	COG2391	methyltransferase activity
I6I08_RS05690	COG0425	Belongs to the sulfur carrier protein TusA family
I6I08_RS05695	COG0667	Aldo Keto reductase
I6I08_RS05700	COG4604	ABC transporter, ATP-binding protein
I6I08_RS05705	COG4605	iron ion homeostasis
I6I08_RS05710	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I08_RS05715	COG4607	ABC-type enterochelin transport system periplasmic component
I6I08_RS05725	COG1252	NADH dehydrogenase
I6I08_RS05730	COG0339	signal peptide processing
I6I08_RS05735	COG0028	Belongs to the TPP enzyme family
I6I08_RS05745	COG0477	Major facilitator Superfamily
I6I08_RS05765	COG3152	Membrane
I6I08_RS05790	COG0587	DNA-directed DNA polymerase activity
I6I08_RS05810	COG1435	thymidine kinase activity
I6I08_RS05815	COG0671	phosphoesterase, PA-phosphatase related
I6I08_RS05830	COG1881	PFAM PEBP family protein
I6I08_RS05835	COG4221	oxidoreductase activity
I6I08_RS05840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I08_RS05855	COG4555	ABC transporter
I6I08_RS05870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I08_RS05875	COG1309	transcriptional regulator
I6I08_RS05885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I08_RS05890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I08_RS05895	COG0531	amino acid
I6I08_RS05900	COG0569	domain protein
I6I08_RS05945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I08_RS05955	COG0454	-acetyltransferase
I6I08_RS05955	COG0456	acetyltransferase
I6I08_RS05960	COG0187	DNA topoisomerase II activity
I6I08_RS05995	COG0351	phosphomethylpyrimidine kinase
I6I08_RS06005	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I08_RS06010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I08_RS06015	COG0142	geranyltranstransferase activity
I6I08_RS06020	COG0515	serine threonine protein kinase
I6I08_RS06020	COG2815	serine threonine protein kinase
I6I08_RS06025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I08_RS06030	COG0205	6-phosphofructokinase activity
I6I08_RS06055	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I08_RS06065	COG0488	(ABC) transporter
I6I08_RS06095	COG1119	ATPase activity
I6I08_RS06105	COG0297	glycogen (starch) synthase activity
I6I08_RS06115	COG0560	Phosphoserine phosphatase
I6I08_RS06140	COG0423	glycine-tRNA ligase activity
I6I08_RS06155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I08_RS06165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I08_RS06170	COG1381	Involved in DNA repair and RecF pathway recombination
I6I08_RS06175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I08_RS06180	COG1131	(ABC) transporter
I6I08_RS06190	COG1476	TRANSCRIPTIONal
I6I08_RS06195	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I08_RS06205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I08_RS06215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I08_RS06270	COG0842	Transport permease protein
I6I08_RS06300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I08_RS06305	COG0484	heat shock protein binding
I6I08_RS06310	COG1420	regulation of RNA biosynthetic process
I6I08_RS06325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I08_RS06340	COG2807	transmembrane transport
I6I08_RS06345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I08_RS06355	COG0481	GTPase activity
I6I08_RS06365	COG1404	Belongs to the peptidase S8 family
I6I08_RS06370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I08_RS06375	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I08_RS06380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I08_RS06390	COG0159	tryptophan synthase activity
I6I08_RS06415	COG0268	Binds directly to 16S ribosomal RNA
I6I08_RS06420	COG4868	Belongs to the UPF0371 family
I6I08_RS06435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I08_RS06435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I08_RS06440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I08_RS06465	COG0438	transferase activity, transferring glycosyl groups
I6I08_RS06470	COG0433	COG0433 Predicted ATPase
I6I08_RS06475	COG0495	leucyl-tRNA aminoacylation
I6I08_RS06485	COG0537	adenosine 5'-monophosphoramidase activity
I6I08_RS06520	COG0733	neurotransmitter:sodium symporter activity
I6I08_RS06525	COG0813	purine-nucleoside phosphorylase activity
I6I08_RS06540	COG2095	MarC family integral membrane protein
I6I08_RS06555	COG0406	alpha-ribazole phosphatase activity
I6I08_RS06560	COG0799	negative regulation of ribosome biogenesis
I6I08_RS06570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I08_RS06580	COG1349	DNA-binding transcription factor activity
I6I08_RS06585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I08_RS06595	COG0297	glycogen (starch) synthase activity
I6I08_RS06600	COG1132	(ABC) transporter
I6I08_RS06615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I08_RS06620	COG5002	protein histidine kinase activity
I6I08_RS06625	COG0745	RESPONSE REGULATOR receiver
I6I08_RS06635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I08_RS06640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I08_RS06645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I08_RS06650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I08_RS06655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I08_RS06660	COG1530	ribonuclease E activity
I6I08_RS06665	COG1271	oxidase subunit
I6I08_RS06670	COG1294	oxidase, subunit
I6I08_RS06675	COG4988	ABC transporter
I6I08_RS06680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I08_RS06695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I08_RS06700	COG0571	ribonuclease III activity
I6I08_RS06715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I08_RS06720	COG1609	Transcriptional regulator
I6I08_RS06725	COG0738	Major facilitator superfamily
I6I08_RS06730	COG4154	Belongs to the RbsD FucU family
I6I08_RS06735	COG4806	L-rhamnose isomerase
I6I08_RS06735	COG1070	Carbohydrate kinase
I6I08_RS06745	COG0235	Class ii aldolase
I6I08_RS06760	COG1461	Dihydroxyacetone kinase
I6I08_RS06765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I08_RS06775	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I08_RS06780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I08_RS06790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I08_RS06795	COG0066	3-isopropylmalate dehydratase activity
I6I08_RS06800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I08_RS06815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I08_RS06825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I08_RS06840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I08_RS06850	COG2813	Specifically methylates the guanine in position
I6I08_RS06860	COG1114	Component of the transport system for branched-chain amino acids
I6I08_RS06865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I08_RS06870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I08_RS06885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I08_RS06890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I08_RS06890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I08_RS06895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I08_RS06900	COG0509	glycine decarboxylation via glycine cleavage system
I6I08_RS06905	COG1252	NADH dehydrogenase
I6I08_RS06910	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I08_RS06915	COG2137	regulation of response to DNA damage stimulus
I6I08_RS06920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I08_RS06930	COG1396	sequence-specific DNA binding
I6I08_RS06935	COG1546	Belongs to the CinA family
I6I08_RS06935	COG1058	Belongs to the CinA family
I6I08_RS06950	COG1674	ftsk spoiiie
I6I08_RS06960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I08_RS06965	COG0726	polysaccharide deacetylase
I6I08_RS06995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I08_RS07005	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I08_RS07010	COG1115	amino acid carrier protein
I6I08_RS07015	COG1115	amino acid carrier protein
I6I08_RS07020	COG1115	amino acid carrier protein
I6I08_RS07025	COG1115	amino acid carrier protein
I6I08_RS07035	COG4716	Myosin-crossreactive antigen
I6I08_RS07055	COG2040	homocysteine
I6I08_RS07060	COG0833	amino acid
I6I08_RS07065	COG3304	Inner membrane component domain
I6I08_RS07120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I08_RS07125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I08_RS07145	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I08_RS07155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I08_RS07175	COG0363	glucosamine-6-phosphate deaminase activity
I6I08_RS07195	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6I08_RS07200	COG1940	carbohydrate kinase activity
I6I08_RS07205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I08_RS07210	COG4608	Belongs to the ABC transporter superfamily
I6I08_RS07215	COG0444	Belongs to the ABC transporter superfamily
I6I08_RS07225	COG0747	negative chemotaxis
I6I08_RS07260	COG2177	Part of the ABC transporter FtsEX involved in
I6I08_RS07265	COG2884	Cell division ATP-binding protein ftsE
I6I08_RS07280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I08_RS07285	COG1162	GTPase activity
I6I08_RS07295	COG1716	ATPase activity
I6I08_RS07295	COG1131	(ABC) transporter
I6I08_RS07295	COG0842	Transport permease protein
I6I08_RS07300	COG0515	serine threonine protein kinase
I6I08_RS07320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I08_RS07325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I08_RS07345	COG1134	teichoic acid transport
I6I08_RS07355	COG1216	Glycosyl transferase, family 2
I6I08_RS07380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I08_RS07385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I08_RS07390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I08_RS07395	COG1316	TRANSCRIPTIONal
I6I08_RS07400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I08_RS07415	COG0473	3-isopropylmalate dehydrogenase activity
I6I08_RS07430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I08_RS07445	COG0569	domain protein
I6I08_RS07445	COG2985	domain, Protein
I6I08_RS07450	COG2966	Psort location CytoplasmicMembrane, score
I6I08_RS07480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I08_RS07485	COG0154	amidase activity
I6I08_RS07490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I08_RS07500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I08_RS07505	COG1674	ftsk spoiiie
I6I08_RS07535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I08_RS07545	COG1733	regulation of RNA biosynthetic process
I6I08_RS07565	COG1174	glycine betaine transport
I6I08_RS07585	COG0114	fumarate hydratase activity
I6I08_RS07630	COG0513	Belongs to the DEAD box helicase family
I6I08_RS07635	COG2095	MarC family integral membrane protein
I6I08_RS07645	COG0673	inositol 2-dehydrogenase activity
I6I08_RS07650	COG0006	proline dipeptidase activity
I6I08_RS07665	COG1082	Xylose isomerase domain protein TIM barrel
I6I08_RS07675	COG2239	Acts as a magnesium transporter
I6I08_RS07690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I08_RS07705	COG1611	Belongs to the LOG family
I6I08_RS07710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I08_RS07725	COG1121	(ABC) transporter
I6I08_RS07730	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I08_RS07755	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I08_RS07760	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I08_RS07765	COG3845	ABC transporter
I6I08_RS07770	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I08_RS07790	COG1349	DNA-binding transcription factor activity
I6I08_RS07795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I08_RS07805	COG0577	efflux transmembrane transporter activity
I6I08_RS07805	COG1136	(ABC) transporter
I6I08_RS07810	COG0577	efflux transmembrane transporter activity
I6I08_RS07810	COG1136	(ABC) transporter
I6I08_RS07820	COG1254	Belongs to the acylphosphatase family
I6I08_RS07840	COG1621	beta-fructofuranosidase activity
I6I08_RS07845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I08_RS07850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I08_RS07860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I08_RS07865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I08_RS07870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I08_RS07875	COG0254	rRNA binding
I6I08_RS07880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I08_RS07920	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6I08_RS07930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I08_RS07935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I08_RS07940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I08_RS07945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I08_RS07950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I08_RS07955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I08_RS07965	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I08_RS07975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I08_RS07985	COG2197	response regulator
I6I08_RS07990	COG2205	protein histidine kinase activity
I6I08_RS08010	COG0693	protein deglycase activity
I6I08_RS08015	COG5002	protein histidine kinase activity
I6I08_RS08025	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I08_RS08035	COG3842	ATPase activity
I6I08_RS08045	COG4268	DNA restriction-modification system
I6I08_RS08050	COG1401	restriction endodeoxyribonuclease activity
I6I08_RS08060	COG3654	unkown
I6I08_RS08070	COG2267	carboxylic ester hydrolase activity
I6I08_RS08110	COG4585	Histidine kinase
I6I08_RS08115	COG1131	(ABC) transporter
I6I08_RS08140	COG0519	Catalyzes the synthesis of GMP from XMP
I6I08_RS08140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I08_RS08160	COG2814	Major facilitator Superfamily
I6I08_RS08170	COG3962	Belongs to the TPP enzyme family
I6I08_RS08175	COG3718	enzyme involved in inositol metabolism
I6I08_RS08190	COG2188	Transcriptional regulator
I6I08_RS08195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I08_RS08200	COG0673	inositol 2-dehydrogenase activity
I6I08_RS08205	COG2017	converts alpha-aldose to the beta-anomer
I6I08_RS08210	COG1609	Transcriptional regulator
I6I08_RS08215	COG0673	inositol 2-dehydrogenase activity
I6I08_RS08220	COG2814	Major facilitator Superfamily
I6I08_RS08225	COG1082	Xylose isomerase domain protein TIM barrel
I6I08_RS08255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I08_RS08260	COG1131	(ABC) transporter
I6I08_RS08275	COG4585	Histidine kinase
I6I08_RS08280	COG2197	response regulator
I6I08_RS08290	COG0328	RNA-DNA hybrid ribonuclease activity
I6I08_RS08325	COG4975	Glucose uptake
I6I08_RS08330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I08_RS08335	COG0516	GMP reductase activity
I6I08_RS08355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I08_RS08360	COG2949	membrane
I6I08_RS08370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I08_RS08375	COG2375	cellular response to nickel ion
I6I08_RS08375	COG1132	(ABC) transporter
I6I08_RS08385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I08_RS08395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I08_RS08400	COG1053	succinate dehydrogenase
I6I08_RS08425	COG0802	atpase or kinase
I6I08_RS08430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I08_RS08440	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I08_RS08450	COG1072	(Pantothenic acid kinase))
I6I08_RS08455	COG0596	Alpha beta hydrolase
I6I08_RS08460	COG1396	sequence-specific DNA binding
I6I08_RS08495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I08_RS08500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I08_RS08505	COG0101	tRNA pseudouridine synthase activity
I6I08_RS08515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6I08_RS08520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I08_RS08525	COG1285	pathogenesis
I6I08_RS08535	COG0203	ribosomal protein L17
I6I08_RS08540	COG0202	RNA polymerase activity
I6I08_RS08545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I08_RS08550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I08_RS08555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I08_RS08560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I08_RS08565	COG0024	Methionine aminopeptidase
I6I08_RS08570	COG0563	adenylate kinase activity
I6I08_RS08585	COG1841	ribosomal large subunit assembly
I6I08_RS08590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I08_RS08595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I08_RS08600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I08_RS08605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I08_RS08610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I08_RS08615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I08_RS08620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I08_RS08625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I08_RS08630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I08_RS08635	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I08_RS08640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I08_RS08645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I08_RS08650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I08_RS08655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I08_RS08660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I08_RS08665	COG0089	rRNA binding
I6I08_RS08680	COG0051	transcription antitermination factor activity, RNA binding
I6I08_RS08700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I08_RS08705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I08_RS08710	COG0049	tRNA binding
I6I08_RS08715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I08_RS08740	COG2894	cell division
I6I08_RS08765	COG3851	Histidine kinase
I6I08_RS08770	COG2197	response regulator
I6I08_RS08810	COG2885	chlorophyll binding
I6I08_RS08830	COG0081	regulation of translation
I6I08_RS08835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I08_RS08840	COG0250	Participates in transcription elongation, termination and antitermination
I6I08_RS08845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I08_RS08855	COG0436	Aminotransferase
I6I08_RS08875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I08_RS08880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I08_RS08895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I08_RS08920	COG1461	Dihydroxyacetone kinase
I6I08_RS08925	COG2376	Dihydroxyacetone kinase
I6I08_RS08950	COG2814	Major facilitator Superfamily
I6I08_RS08970	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I6I08_RS09005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I08_RS09010	COG2390	Transcriptional regulator
I6I08_RS09015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I08_RS09020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I08_RS09025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I08_RS09030	COG2217	Heavy metal translocating P-type atpase
I6I08_RS09035	COG1620	l-lactate permease
I6I08_RS09045	COG0247	lactate metabolic process
I6I08_RS09050	COG1139	Iron-sulfur cluster binding protein
I6I08_RS09055	COG1556	Lactate utilization protein
I6I08_RS09070	COG3104	oligopeptide transport
I6I08_RS09075	COG3104	oligopeptide transport
I6I08_RS09085	COG4592	Periplasmic binding protein
I6I08_RS09090	COG1120	ATPase activity
I6I08_RS09095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I08_RS09100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I08_RS09110	COG1136	(ABC) transporter
I6I08_RS09140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I08_RS09145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I08_RS09150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I08_RS09175	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I08_RS09180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I08_RS09190	COG1136	(ABC) transporter
I6I08_RS09190	COG0577	efflux transmembrane transporter activity
I6I08_RS09255	COG1132	(ABC) transporter
I6I08_RS09275	COG2197	response regulator
I6I08_RS09285	COG2076	Multidrug Resistance protein
I6I08_RS09310	COG0302	gtp cyclohydrolase
I6I08_RS09315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I08_RS09325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I08_RS09335	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I08_RS09340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I08_RS09350	COG2873	o-acetylhomoserine
I6I08_RS09355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I08_RS09370	COG4115	mRNA cleavage
I6I08_RS09440	COG0012	GTP binding
I6I08_RS09450	COG1322	Protein conserved in bacteria
I6I08_RS09455	COG2261	transglycosylase associated protein
I6I08_RS09485	COG1595	DNA-templated transcription, initiation
I6I08_RS09500	COG0833	amino acid
I6I08_RS09505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I08_RS09510	COG1570	exodeoxyribonuclease VII activity
I6I08_RS09525	COG1722	exodeoxyribonuclease VII activity
I6I08_RS09545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I08_RS09585	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I08_RS09595	COG1136	(ABC) transporter
I6I08_RS09600	COG0577	efflux transmembrane transporter activity
I6I08_RS09605	COG1132	(ABC) transporter
I6I08_RS09610	COG1132	(ABC) transporter
I6I08_RS09665	COG1201	RNA secondary structure unwinding
I6I08_RS09670	COG3973	AAA domain
I6I08_RS09680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I08_RS09685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I08_RS09690	COG0557	exoribonuclease II activity
I6I08_RS09700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I08_RS09700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I08_RS09700	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I08_RS09710	COG1349	DNA-binding transcription factor activity
I6I08_RS09715	COG0737	Belongs to the 5'-nucleotidase family
I6I08_RS09720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I08_RS09730	COG1090	epimerase
I6I08_RS09760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I08_RS09775	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I08_RS09795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I08_RS09800	COG0151	Belongs to the GarS family
I6I08_RS09835	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I08_RS09870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I08_RS09900	COG0191	fructose-bisphosphate aldolase activity
I6I08_RS09905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I08_RS09910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I08_RS09915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I08_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
I6I08_RS09935	COG2176	DNA-directed DNA polymerase activity
I6I08_RS09945	COG0717	Belongs to the dCTP deaminase family
I6I08_RS10010	COG0714	Associated with various cellular activities
I6I08_RS10065	COG2860	membrane
I6I08_RS10070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I08_RS10090	COG1643	Atp-dependent helicase
I6I08_RS10100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I08_RS10130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I08_RS10140	COG0745	RESPONSE REGULATOR receiver
I6I08_RS10145	COG5002	protein histidine kinase activity
I6I08_RS10155	COG0588	phosphoglycerate mutase activity
I6I08_RS10170	COG1113	amino acid transport
I6I08_RS10175	COG0252	asparaginase activity
I6I08_RS10200	COG0470	DNA polymerase III
I6I08_RS10205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I08_RS10230	COG2188	Transcriptional regulator
I6I08_RS10240	COG2885	chlorophyll binding
I6I08_RS10245	COG5002	protein histidine kinase activity
I6I08_RS10250	COG0745	RESPONSE REGULATOR receiver
I6I08_RS10260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I08_RS10260	COG1754	DNA topoisomerase type I activity
I6I08_RS10275	COG0745	RESPONSE REGULATOR receiver
I6I08_RS10280	COG2205	protein histidine kinase activity
I6I08_RS10310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I08_RS10315	COG0450	alkyl hydroperoxide reductase
I6I08_RS10375	COG3548	integral membrane protein
I6I08_RS10380	COG0596	Alpha beta hydrolase
I6I08_RS10390	COG1136	(ABC) transporter
I6I08_RS10415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I08_RS10420	COG1408	metallophosphoesterase
I6I08_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
I6I08_RS10450	COG1597	lipid kinase activity
I6I08_RS10470	COG1918	ferrous iron import across plasma membrane
I6I08_RS10470	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I08_RS10485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I08_RS10485	COG1918	ferrous iron import across plasma membrane
I6I08_RS10510	COG2207	Transcriptional regulator
I6I08_RS10510	COG3708	Transcriptional regulator
I6I08_RS10535	COG0783	Belongs to the Dps family
I6I08_RS10555	COG3253	May function as heme-dependent peroxidase
I6I08_RS10555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I08_RS10560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I08_RS10570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I08_RS10580	COG0181	hydroxymethylbilane synthase activity
I6I08_RS10590	COG0113	porphobilinogen synthase activity
I6I08_RS10595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I08_RS10605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I08_RS10625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I08_RS10655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I08_RS10710	COG2233	PERMEase
I6I08_RS10740	COG0702	epimerase
I6I08_RS10775	COG1643	Atp-dependent helicase
I6I08_RS10840	COG4974	Belongs to the 'phage' integrase family
I6I08_RS10850	COG0590	tRNA wobble adenosine to inosine editing
I6I08_RS10850	COG0037	tRNA processing
I6I08_RS10855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I08_RS10860	COG0656	L-ascorbic acid biosynthetic process
I6I08_RS10870	COG0577	efflux transmembrane transporter activity
I6I08_RS10870	COG1136	(ABC) transporter
I6I08_RS10880	COG4585	Histidine kinase
I6I08_RS10885	COG2197	response regulator
I6I08_RS10890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I08_RS10915	COG2205	protein histidine kinase activity
I6I08_RS10925	COG1929	Belongs to the glycerate kinase type-1 family
I6I08_RS10935	COG0732	type I restriction modification DNA specificity domain
I6I08_RS10960	COG4585	Histidine kinase
I6I08_RS10970	COG1136	(ABC) transporter
I6I08_RS10970	COG0577	efflux transmembrane transporter activity
I6I08_RS10975	COG1464	Belongs to the NlpA lipoprotein family
I6I08_RS10980	COG2011	ABC-type metal ion transport system permease component
I6I08_RS10995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I08_RS11015	COG0463	Glycosyl transferase, family 2
I6I08_RS11025	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I08_RS11035	COG3739	integral membrane protein
I6I08_RS11115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I08_RS11120	COG1950	PFAM Membrane protein of
I6I08_RS11135	COG2813	Specifically methylates the guanine in position
I6I08_RS11170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I08_RS11215	COG2197	response regulator
I6I08_RS11225	COG1937	Protein conserved in bacteria
I6I08_RS11255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I08_RS11260	COG0626	cystathionine gamma-synthase activity
I6I08_RS11265	COG0596	Alpha beta hydrolase
I6I08_RS11315	COG1653	transport
I6I08_RS11320	COG0561	phosphatase activity
I6I08_RS11325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I08_RS11390	COG0464	growth
I6I08_RS11410	COG0477	Major facilitator Superfamily
I6I08_RS11415	COG1072	(Pantothenic acid kinase))
I6I08_RS11420	COG0385	Bile acid
I6I08_RS11430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I08_RS11435	COG1780	Probably involved in ribonucleotide reductase function
I6I08_RS11475	COG1760	l-serine dehydratase
I6I08_RS11485	COG1733	regulation of RNA biosynthetic process
I6I08_RS11495	COG0351	phosphomethylpyrimidine kinase
I6I08_RS11505	COG1121	(ABC) transporter
I6I08_RS11515	COG0305	Participates in initiation and elongation during chromosome replication
I6I08_RS11520	COG0534	Mate efflux family protein
I6I08_RS11530	COG0359	binds to the 23S rRNA
I6I08_RS11535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I08_RS11545	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I08_RS11550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I08_RS11555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I08_RS11570	COG3764	Sortase (surface protein transpeptidase)
I6I08_RS11625	COG1476	TRANSCRIPTIONal
I6I08_RS11655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I08_RS11660	COG0187	DNA topoisomerase II activity
I6I08_RS11665	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6I08_RS11670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I08_RS11675	COG0592	DNA-directed DNA polymerase activity
I6I08_RS11680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I08_RS11685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I08_RS11690	COG0594	ribonuclease P activity
I6I08_RS11695	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I08_RS11700	COG0706	membrane insertase activity
I6I08_RS11710	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I08_RS11725	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I08_RS11730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I08_RS11740	COG3118	belongs to the thioredoxin family
I6I08_RS11745	COG0492	ferredoxin-NADP+ reductase activity
I6I08_RS11750	COG0728	peptidoglycan biosynthetic process
I6I08_RS11765	COG0617	tRNA 3'-terminal CCA addition
I6I08_RS11770	COG0673	inositol 2-dehydrogenase activity
I6I08_RS11775	COG3345	alpha-galactosidase
I6I08_RS11815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I08_RS11820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I08_RS11835	COG4585	Histidine kinase
I6I08_RS11840	COG2197	response regulator
I6I08_RS11845	COG2815	serine threonine protein kinase
I6I08_RS11845	COG0515	serine threonine protein kinase
I6I08_RS11850	COG0515	serine threonine protein kinase
I6I08_RS11855	COG0768	penicillin binding
I6I08_RS11870	COG1716	ATPase activity
I6I08_RS11875	COG1716	ATPase activity
I6I08_RS11895	COG1966	Carbon starvation protein
I6I08_RS11900	COG2985	domain, Protein
I6I08_RS11900	COG0569	domain protein
I6I08_RS11905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I08_RS11935	COG2409	Drug exporters of the RND superfamily
I6I08_RS11945	COG1854	S-ribosylhomocysteine lyase activity
I6I08_RS11955	COG0628	permease
I6I08_RS11960	COG1940	carbohydrate kinase activity
I6I08_RS11965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I08_RS11965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I08_RS11970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I08_RS11975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I08_RS11985	COG1113	amino acid transport
I6I08_RS11990	COG0483	inositol monophosphate 1-phosphatase activity
I6I08_RS11995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I08_RS12020	COG2755	lipolytic protein G-D-S-L family
I6I08_RS12060	COG2197	response regulator
I6I08_RS12065	COG2197	response regulator
I6I08_RS12075	COG1131	(ABC) transporter
I6I08_RS12090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I08_RS12095	COG0247	lactate metabolic process
I6I08_RS12095	COG2181	nitrate reductase activity
I6I08_RS12125	COG1733	regulation of RNA biosynthetic process
I6I08_RS12145	COG3842	ATPase activity
I6I08_RS12150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I08_RS12155	COG0601	transmembrane transport
I6I08_RS12240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I08_RS12315	COG2977	Belongs to the P-Pant transferase superfamily
I6I08_RS12320	COG1309	transcriptional regulator
I6I08_RS12325	COG0477	Major facilitator Superfamily
I6I08_RS12365	COG0778	Nitroreductase
I6I08_RS12435	COG4585	Histidine kinase
I6I08_RS12440	COG2197	response regulator
I6I08_RS12465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I08_RS12470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I08_RS12480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I08_RS12485	COG2814	Major facilitator Superfamily
I6I08_RS12505	COG0443	Heat shock 70 kDa protein
I6I08_RS12510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I08_RS12515	COG0484	heat shock protein binding
I6I08_RS12545	COG2205	protein histidine kinase activity
I6I08_RS12550	COG0745	RESPONSE REGULATOR receiver
I6I08_RS12570	COG0577	efflux transmembrane transporter activity
I6I08_RS12570	COG1136	(ABC) transporter
I6I08_RS12585	COG3655	Transcriptional regulator
I6I08_RS12605	COG0542	response to heat
I6I08_RS12630	COG0546	phosphoglycolate phosphatase activity
I6I08_RS12635	COG1609	Transcriptional regulator
I6I08_RS12640	COG1621	beta-fructofuranosidase activity
I6I08_RS12655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I08_RS12660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I08_RS12660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I08_RS12665	COG3715	PTS system
I6I08_RS12670	COG3716	PTS system mannose fructose sorbose family IID component
I6I08_RS12690	COG0561	phosphatase activity
I6I08_RS12710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I08_RS12740	COG3842	ATPase activity
I6I08_RS12765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I08_RS12770	COG0215	cysteine-tRNA ligase activity
I6I08_RS12775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I08_RS12785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I08_RS12800	COG0459	protein refolding
I6I08_RS12815	COG2205	protein histidine kinase activity
I6I08_RS12820	COG0745	RESPONSE REGULATOR receiver
I6I08_RS12830	COG1842	Phage shock protein A
I6I08_RS12845	COG1061	Type III restriction enzyme res subunit
I6I08_RS12870	COG0789	Transcriptional regulator
I6I08_RS12890	COG1201	RNA secondary structure unwinding
I6I08_RS12895	COG2252	PERMEase
I6I08_RS12920	COG3103	Sh3 type 3 domain protein
I6I08_RS12920	COG1388	LysM domain
I6I08_RS12920	COG0791	NLP P60 protein
I6I08_RS12935	COG0582	viral genome integration into host DNA
I6I08_RS12965	COG1970	mechanosensitive ion channel activity
I6I08_RS12975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I08_RS13085	COG1215	transferase activity, transferring glycosyl groups
I6I08_RS13090	COG0640	Transcriptional regulator
I6I08_RS13095	COG2814	Major facilitator Superfamily
I6I08_RS13105	COG1297	OPT oligopeptide transporter protein
I6I08_RS13145	COG1335	isochorismatase
I6I08_RS13155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I08_RS13160	COG0084	hydrolase, TatD family'
I6I08_RS13175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I08_RS13180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I08_RS13185	COG0488	(ABC) transporter
I6I08_RS13225	COG0714	Associated with various cellular activities
I6I08_RS13235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I08_RS13235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I08_RS13240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity