locus-tag	class	description
AXE84_RS00010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXE84_RS00020	COG1349	DNA-binding transcription factor activity
AXE84_RS00025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXE84_RS00035	COG0297	glycogen (starch) synthase activity
AXE84_RS00040	COG1132	(ABC) transporter
AXE84_RS00055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AXE84_RS00060	COG2205	protein histidine kinase activity
AXE84_RS00065	COG0745	RESPONSE REGULATOR receiver
AXE84_RS00075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AXE84_RS00080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXE84_RS00085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXE84_RS00090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXE84_RS00095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AXE84_RS00100	COG1530	ribonuclease E activity
AXE84_RS00105	COG1271	oxidase subunit
AXE84_RS00110	COG1294	oxidase, subunit
AXE84_RS00115	COG4988	ABC transporter
AXE84_RS00120	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AXE84_RS00135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXE84_RS00140	COG0571	ribonuclease III activity
AXE84_RS00155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXE84_RS00160	COG1609	Transcriptional regulator
AXE84_RS00165	COG0738	Major facilitator superfamily
AXE84_RS00170	COG4154	Belongs to the RbsD FucU family
AXE84_RS00175	COG1070	Carbohydrate kinase
AXE84_RS00185	COG0235	Class ii aldolase
AXE84_RS00200	COG1461	Dihydroxyacetone kinase
AXE84_RS00205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXE84_RS00215	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXE84_RS00220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXE84_RS00230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXE84_RS00235	COG0066	3-isopropylmalate dehydratase activity
AXE84_RS00255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXE84_RS00265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXE84_RS00280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXE84_RS00290	COG2813	Specifically methylates the guanine in position
AXE84_RS00300	COG1114	Component of the transport system for branched-chain amino acids
AXE84_RS00305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXE84_RS00310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXE84_RS00335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE84_RS00340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXE84_RS00340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXE84_RS00350	COG0509	glycine decarboxylation via glycine cleavage system
AXE84_RS00360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AXE84_RS00365	COG2137	regulation of response to DNA damage stimulus
AXE84_RS00370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXE84_RS00380	COG1396	sequence-specific DNA binding
AXE84_RS00385	COG1546	Belongs to the CinA family
AXE84_RS00385	COG1058	Belongs to the CinA family
AXE84_RS00395	COG2843	Capsule synthesis protein
AXE84_RS00400	COG1674	ftsk spoiiie
AXE84_RS00405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXE84_RS00410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AXE84_RS00415	COG0726	polysaccharide deacetylase
AXE84_RS00450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXE84_RS00460	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXE84_RS00465	COG1115	amino acid carrier protein
AXE84_RS00470	COG1115	amino acid carrier protein
AXE84_RS00475	COG1115	amino acid carrier protein
AXE84_RS00480	COG1115	amino acid carrier protein
AXE84_RS00505	COG2040	homocysteine
AXE84_RS00510	COG0833	amino acid
AXE84_RS00515	COG3304	Inner membrane component domain
AXE84_RS00565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AXE84_RS00570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXE84_RS00590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXE84_RS00600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AXE84_RS00620	COG0363	glucosamine-6-phosphate deaminase activity
AXE84_RS00640	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AXE84_RS00645	COG1940	carbohydrate kinase activity
AXE84_RS00650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXE84_RS00655	COG4608	Belongs to the ABC transporter superfamily
AXE84_RS00660	COG0444	Belongs to the ABC transporter superfamily
AXE84_RS00670	COG0747	negative chemotaxis
AXE84_RS00705	COG2177	Part of the ABC transporter FtsEX involved in
AXE84_RS00710	COG2884	Cell division ATP-binding protein ftsE
AXE84_RS00725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXE84_RS00730	COG1162	GTPase activity
AXE84_RS00755	COG0842	Transport permease protein
AXE84_RS00755	COG1131	(ABC) transporter
AXE84_RS00755	COG1716	ATPase activity
AXE84_RS00760	COG0515	serine threonine protein kinase
AXE84_RS00765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AXE84_RS00780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXE84_RS00790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXE84_RS00810	COG1134	teichoic acid transport
AXE84_RS00820	COG1216	Glycosyl transferase, family 2
AXE84_RS00840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXE84_RS00845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXE84_RS00845	COG0463	Glycosyl transferase, family 2
AXE84_RS00850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXE84_RS00855	COG1316	TRANSCRIPTIONal
AXE84_RS00860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXE84_RS00875	COG0473	3-isopropylmalate dehydrogenase activity
AXE84_RS00890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXE84_RS00905	COG2985	domain, Protein
AXE84_RS00905	COG0569	domain protein
AXE84_RS00910	COG2966	Psort location CytoplasmicMembrane, score
AXE84_RS00940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXE84_RS00945	COG0154	amidase activity
AXE84_RS00950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXE84_RS00965	COG1674	ftsk spoiiie
AXE84_RS00995	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXE84_RS01025	COG1174	glycine betaine transport
AXE84_RS01035	COG0346	lactoylglutathione lyase activity
AXE84_RS01050	COG0114	fumarate hydratase activity
AXE84_RS01095	COG0513	Belongs to the DEAD box helicase family
AXE84_RS01100	COG2095	MarC family integral membrane protein
AXE84_RS01115	COG0006	proline dipeptidase activity
AXE84_RS01130	COG1082	Xylose isomerase domain protein TIM barrel
AXE84_RS01140	COG2239	Acts as a magnesium transporter
AXE84_RS01155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXE84_RS01165	COG1611	Belongs to the LOG family
AXE84_RS01170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXE84_RS01185	COG1121	(ABC) transporter
AXE84_RS01190	COG0803	Belongs to the bacterial solute-binding protein 9 family
AXE84_RS01220	COG1079	Belongs to the binding-protein-dependent transport system permease family
AXE84_RS01225	COG4603	Belongs to the binding-protein-dependent transport system permease family
AXE84_RS01230	COG3845	ABC transporter
AXE84_RS01235	COG1744	ABC transporter substrate-binding protein PnrA-like
AXE84_RS01255	COG1349	DNA-binding transcription factor activity
AXE84_RS01260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXE84_RS01270	COG0577	efflux transmembrane transporter activity
AXE84_RS01270	COG1136	(ABC) transporter
AXE84_RS01275	COG1136	(ABC) transporter
AXE84_RS01275	COG0577	efflux transmembrane transporter activity
AXE84_RS01285	COG1254	Belongs to the acylphosphatase family
AXE84_RS01305	COG1621	beta-fructofuranosidase activity
AXE84_RS01310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXE84_RS01315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXE84_RS01325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXE84_RS01330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXE84_RS01335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXE84_RS01340	COG0254	rRNA binding
AXE84_RS01345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXE84_RS01355	COG0754	glutathionylspermidine amidase activity
AXE84_RS01370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXE84_RS01380	COG0832	Belongs to the urease beta subunit family
AXE84_RS01385	COG0804	urea catabolic process
AXE84_RS01395	COG0830	nickel cation binding
AXE84_RS01400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AXE84_RS01425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AXE84_RS01435	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AXE84_RS01445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXE84_RS01450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXE84_RS01455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXE84_RS01460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXE84_RS01465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXE84_RS01470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXE84_RS01480	COG0356	it plays a direct role in the translocation of protons across the membrane
AXE84_RS01490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXE84_RS01500	COG2197	response regulator
AXE84_RS01505	COG2205	protein histidine kinase activity
AXE84_RS01525	COG0693	protein deglycase activity
AXE84_RS01535	COG4268	DNA restriction-modification system
AXE84_RS01540	COG1401	restriction endodeoxyribonuclease activity
AXE84_RS01550	COG3654	unkown
AXE84_RS01560	COG2267	carboxylic ester hydrolase activity
AXE84_RS01595	COG4585	Histidine kinase
AXE84_RS01600	COG1131	(ABC) transporter
AXE84_RS01615	COG0519	Catalyzes the synthesis of GMP from XMP
AXE84_RS01615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXE84_RS01635	COG2814	Major facilitator Superfamily
AXE84_RS01645	COG3962	Belongs to the TPP enzyme family
AXE84_RS01650	COG3718	enzyme involved in inositol metabolism
AXE84_RS01665	COG2188	Transcriptional regulator
AXE84_RS01670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXE84_RS01675	COG0673	inositol 2-dehydrogenase activity
AXE84_RS01680	COG2017	converts alpha-aldose to the beta-anomer
AXE84_RS01690	COG0673	inositol 2-dehydrogenase activity
AXE84_RS01695	COG2814	Major facilitator Superfamily
AXE84_RS01700	COG1082	Xylose isomerase domain protein TIM barrel
AXE84_RS01730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXE84_RS01735	COG1131	(ABC) transporter
AXE84_RS01750	COG4585	Histidine kinase
AXE84_RS01755	COG2197	response regulator
AXE84_RS01765	COG0328	RNA-DNA hybrid ribonuclease activity
AXE84_RS01810	COG4975	Glucose uptake
AXE84_RS01815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXE84_RS01820	COG0516	GMP reductase activity
AXE84_RS01840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXE84_RS01845	COG2949	membrane
AXE84_RS01855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AXE84_RS01865	COG1132	(ABC) transporter
AXE84_RS01865	COG2375	cellular response to nickel ion
AXE84_RS01875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXE84_RS01885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXE84_RS01890	COG1053	succinate dehydrogenase
AXE84_RS01915	COG0802	atpase or kinase
AXE84_RS01920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXE84_RS01930	COG0736	holo-[acyl-carrier-protein] synthase activity
AXE84_RS01940	COG1072	(Pantothenic acid kinase))
AXE84_RS01975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXE84_RS01980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXE84_RS01985	COG0101	tRNA pseudouridine synthase activity
AXE84_RS01995	COG1285	pathogenesis
AXE84_RS02010	COG0202	RNA polymerase activity
AXE84_RS02015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXE84_RS02020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXE84_RS02025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXE84_RS02030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXE84_RS02035	COG0024	Methionine aminopeptidase
AXE84_RS02040	COG0563	adenylate kinase activity
AXE84_RS02055	COG1841	ribosomal large subunit assembly
AXE84_RS02060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXE84_RS02065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AXE84_RS02070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXE84_RS02075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXE84_RS02080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXE84_RS02085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXE84_RS02090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXE84_RS02095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXE84_RS02100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXE84_RS02105	COG0255	Belongs to the universal ribosomal protein uL29 family
AXE84_RS02110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXE84_RS02115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXE84_RS02120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXE84_RS02125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXE84_RS02130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXE84_RS02135	COG0089	rRNA binding
AXE84_RS02145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXE84_RS02150	COG0051	transcription antitermination factor activity, RNA binding
AXE84_RS02170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXE84_RS02175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXE84_RS02180	COG0049	tRNA binding
AXE84_RS02185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXE84_RS02210	COG2894	cell division
AXE84_RS02255	COG2885	chlorophyll binding
AXE84_RS02280	COG0081	regulation of translation
AXE84_RS02285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXE84_RS02290	COG0250	Participates in transcription elongation, termination and antitermination
AXE84_RS02295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXE84_RS02305	COG0436	Aminotransferase
AXE84_RS02325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AXE84_RS02330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXE84_RS02340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXE84_RS02365	COG1461	Dihydroxyacetone kinase
AXE84_RS02370	COG2376	Dihydroxyacetone kinase
AXE84_RS02395	COG2814	Major facilitator Superfamily
AXE84_RS02405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AXE84_RS02410	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AXE84_RS02440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AXE84_RS02450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXE84_RS02455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AXE84_RS02460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXE84_RS02465	COG2217	Heavy metal translocating P-type atpase
AXE84_RS02470	COG1620	l-lactate permease
AXE84_RS02480	COG0247	lactate metabolic process
AXE84_RS02485	COG1139	Iron-sulfur cluster binding protein
AXE84_RS02490	COG1556	Lactate utilization protein
AXE84_RS02505	COG3104	oligopeptide transport
AXE84_RS02510	COG3104	oligopeptide transport
AXE84_RS02555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXE84_RS02565	COG4592	Periplasmic binding protein
AXE84_RS02570	COG1120	ATPase activity
AXE84_RS02575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXE84_RS02580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXE84_RS02590	COG1136	(ABC) transporter
AXE84_RS02605	COG3599	regulation of cell shape
AXE84_RS02625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXE84_RS02635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXE84_RS02640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXE84_RS02670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXE84_RS02675	COG0577	efflux transmembrane transporter activity
AXE84_RS02675	COG1136	(ABC) transporter
AXE84_RS02680	COG1136	(ABC) transporter
AXE84_RS02685	COG1136	(ABC) transporter
AXE84_RS02685	COG0577	efflux transmembrane transporter activity
AXE84_RS02690	COG2197	response regulator
AXE84_RS02705	COG2076	Multidrug Resistance protein
AXE84_RS02725	COG0302	gtp cyclohydrolase
AXE84_RS02730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXE84_RS02770	COG2801	Transposase and inactivated derivatives
AXE84_RS02770	COG3415	Transposase
AXE84_RS02780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AXE84_RS02790	COG2027	D-alanyl-D-alanine carboxypeptidase
AXE84_RS02795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AXE84_RS02810	COG2873	o-acetylhomoserine
AXE84_RS02815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXE84_RS02825	COG4115	mRNA cleavage
AXE84_RS02855	COG0012	GTP binding
AXE84_RS02865	COG1322	Protein conserved in bacteria
AXE84_RS02870	COG2261	transglycosylase associated protein
AXE84_RS02895	COG1595	DNA-templated transcription, initiation
AXE84_RS02910	COG0833	amino acid
AXE84_RS02915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AXE84_RS02920	COG1570	exodeoxyribonuclease VII activity
AXE84_RS02925	COG1722	exodeoxyribonuclease VII activity
AXE84_RS02945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE84_RS02985	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE84_RS03010	COG1136	(ABC) transporter
AXE84_RS03015	COG0577	efflux transmembrane transporter activity
AXE84_RS03020	COG1132	(ABC) transporter
AXE84_RS03025	COG1132	(ABC) transporter
AXE84_RS03050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXE84_RS03055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AXE84_RS03070	COG0557	exoribonuclease II activity
AXE84_RS03080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXE84_RS03080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AXE84_RS03080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXE84_RS03090	COG1349	DNA-binding transcription factor activity
AXE84_RS03095	COG0737	Belongs to the 5'-nucleotidase family
AXE84_RS03095	COG4085	toxin activity
AXE84_RS03095	COG1525	nuclease
AXE84_RS03100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXE84_RS03110	COG1090	epimerase
AXE84_RS03140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXE84_RS03155	COG0047	phosphoribosylformylglycinamidine synthase activity
AXE84_RS03175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXE84_RS03180	COG0151	Belongs to the GarS family
AXE84_RS03210	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AXE84_RS03250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXE84_RS03280	COG0191	fructose-bisphosphate aldolase activity
AXE84_RS03285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE84_RS03290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXE84_RS03295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AXE84_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
AXE84_RS03325	COG0717	Belongs to the dCTP deaminase family
AXE84_RS03390	COG0714	Associated with various cellular activities
AXE84_RS03425	COG5650	phosphatidylinositol metabolic process
AXE84_RS03445	COG2860	membrane
AXE84_RS03450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AXE84_RS03475	COG1643	Atp-dependent helicase
AXE84_RS03480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXE84_RS03510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AXE84_RS03520	COG0745	RESPONSE REGULATOR receiver
AXE84_RS03525	COG5002	protein histidine kinase activity
AXE84_RS03535	COG0588	phosphoglycerate mutase activity
AXE84_RS03550	COG1113	amino acid transport
AXE84_RS03555	COG0252	asparaginase activity
AXE84_RS03585	COG0470	DNA polymerase III
AXE84_RS03590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AXE84_RS03615	COG2188	Transcriptional regulator
AXE84_RS03630	COG0642	Histidine kinase
AXE84_RS03635	COG0745	RESPONSE REGULATOR receiver
AXE84_RS03650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXE84_RS03650	COG1754	DNA topoisomerase type I activity
AXE84_RS03665	COG0745	RESPONSE REGULATOR receiver
AXE84_RS03670	COG2205	protein histidine kinase activity
AXE84_RS03695	COG2890	protein-(glutamine-N5) methyltransferase activity
AXE84_RS03705	COG0450	alkyl hydroperoxide reductase
AXE84_RS03755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AXE84_RS03765	COG3548	integral membrane protein
AXE84_RS03770	COG2267	carboxylic ester hydrolase activity
AXE84_RS03780	COG0577	efflux transmembrane transporter activity
AXE84_RS03780	COG1136	(ABC) transporter
AXE84_RS03810	COG1408	metallophosphoesterase
AXE84_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
AXE84_RS03835	COG1597	lipid kinase activity
AXE84_RS03855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AXE84_RS03855	COG1918	ferrous iron import across plasma membrane
AXE84_RS03870	COG1918	ferrous iron import across plasma membrane
AXE84_RS03870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AXE84_RS03895	COG3708	Transcriptional regulator
AXE84_RS03895	COG2207	Transcriptional regulator
AXE84_RS03920	COG0783	Belongs to the Dps family
AXE84_RS03940	COG3253	May function as heme-dependent peroxidase
AXE84_RS03940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXE84_RS03945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXE84_RS03950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXE84_RS03955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXE84_RS03965	COG0181	hydroxymethylbilane synthase activity
AXE84_RS03975	COG0113	porphobilinogen synthase activity
AXE84_RS03980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXE84_RS03990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXE84_RS04020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXE84_RS04040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXE84_RS04075	COG1309	transcriptional regulator
AXE84_RS04095	COG2233	PERMEase
AXE84_RS04120	COG0702	epimerase
AXE84_RS04155	COG1643	Atp-dependent helicase
AXE84_RS04165	COG0037	tRNA processing
AXE84_RS04165	COG0590	tRNA wobble adenosine to inosine editing
AXE84_RS04170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXE84_RS04175	COG0656	L-ascorbic acid biosynthetic process
AXE84_RS04180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AXE84_RS04215	COG4585	Histidine kinase
AXE84_RS04220	COG1569	PIN domain
AXE84_RS04225	COG3311	Transcriptional regulator
AXE84_RS04235	COG0577	efflux transmembrane transporter activity
AXE84_RS04235	COG1136	(ABC) transporter
AXE84_RS04240	COG1464	Belongs to the NlpA lipoprotein family
AXE84_RS04245	COG2011	ABC-type metal ion transport system permease component
AXE84_RS04260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXE84_RS04285	COG0463	Glycosyl transferase, family 2
AXE84_RS04380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXE84_RS04385	COG1950	PFAM Membrane protein of
AXE84_RS04400	COG2813	Specifically methylates the guanine in position
AXE84_RS04435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AXE84_RS04490	COG2197	response regulator
AXE84_RS04500	COG1937	Protein conserved in bacteria
AXE84_RS04555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AXE84_RS04560	COG0626	cystathionine gamma-synthase activity
AXE84_RS04625	COG1653	transport
AXE84_RS04630	COG0561	phosphatase activity
AXE84_RS04635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXE84_RS04655	COG1309	transcriptional regulator
AXE84_RS04665	COG2837	iron assimilation
AXE84_RS04675	COG0672	)-iron permease
AXE84_RS04745	COG1072	(Pantothenic acid kinase))
AXE84_RS04750	COG0385	Bile acid
AXE84_RS04760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXE84_RS04765	COG1780	Probably involved in ribonucleotide reductase function
AXE84_RS04815	COG1760	l-serine dehydratase
AXE84_RS04825	COG1733	regulation of RNA biosynthetic process
AXE84_RS04840	COG0351	phosphomethylpyrimidine kinase
AXE84_RS04850	COG1121	(ABC) transporter
AXE84_RS04860	COG0305	Participates in initiation and elongation during chromosome replication
AXE84_RS04870	COG0359	binds to the 23S rRNA
AXE84_RS04875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXE84_RS04885	COG0360	Binds together with S18 to 16S ribosomal RNA
AXE84_RS04890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXE84_RS04895	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AXE84_RS04905	COG3764	Sortase (surface protein transpeptidase)
AXE84_RS04960	COG1476	TRANSCRIPTIONal
AXE84_RS04990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXE84_RS04995	COG0187	DNA topoisomerase II activity
AXE84_RS05000	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AXE84_RS05005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXE84_RS05010	COG0592	DNA-directed DNA polymerase activity
AXE84_RS05015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXE84_RS05020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AXE84_RS05025	COG0594	ribonuclease P activity
AXE84_RS05030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AXE84_RS05035	COG0706	membrane insertase activity
AXE84_RS05045	COG0357	Ribosomal RNA small subunit methyltransferase G
AXE84_RS05060	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXE84_RS05065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXE84_RS05075	COG3118	belongs to the thioredoxin family
AXE84_RS05080	COG0492	ferredoxin-NADP+ reductase activity
AXE84_RS05100	COG0617	tRNA 3'-terminal CCA addition
AXE84_RS05105	COG0673	inositol 2-dehydrogenase activity
AXE84_RS05110	COG3345	alpha-galactosidase
AXE84_RS05155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AXE84_RS05160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXE84_RS05175	COG0515	serine threonine protein kinase
AXE84_RS05180	COG0768	penicillin binding
AXE84_RS05195	COG1716	ATPase activity
AXE84_RS05200	COG1716	ATPase activity
AXE84_RS05220	COG1966	Carbon starvation protein
AXE84_RS05225	COG2985	domain, Protein
AXE84_RS05225	COG0569	domain protein
AXE84_RS05245	COG1854	S-ribosylhomocysteine lyase activity
AXE84_RS05255	COG0628	permease
AXE84_RS05260	COG1940	carbohydrate kinase activity
AXE84_RS05265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXE84_RS05265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXE84_RS05270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXE84_RS05275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXE84_RS05285	COG1113	amino acid transport
AXE84_RS05290	COG0483	inositol monophosphate 1-phosphatase activity
AXE84_RS05305	COG2197	response regulator
AXE84_RS05350	COG1131	(ABC) transporter
AXE84_RS05400	COG4585	Histidine kinase
AXE84_RS05405	COG2197	response regulator
AXE84_RS05415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXE84_RS05420	COG0247	lactate metabolic process
AXE84_RS05420	COG2181	nitrate reductase activity
AXE84_RS05460	COG3842	ATPase activity
AXE84_RS05520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AXE84_RS05605	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
AXE84_RS05610	COG0778	Nitroreductase
AXE84_RS05655	COG4585	Histidine kinase
AXE84_RS05660	COG2197	response regulator
AXE84_RS05665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXE84_RS05690	COG1131	(ABC) transporter
AXE84_RS05705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXE84_RS05710	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AXE84_RS05720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXE84_RS05740	COG0443	Heat shock 70 kDa protein
AXE84_RS05745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXE84_RS05750	COG0484	heat shock protein binding
AXE84_RS05755	COG0789	Transcriptional regulator
AXE84_RS05780	COG2205	protein histidine kinase activity
AXE84_RS05785	COG0745	RESPONSE REGULATOR receiver
AXE84_RS05805	COG0577	efflux transmembrane transporter activity
AXE84_RS05805	COG1136	(ABC) transporter
AXE84_RS05820	COG3655	Transcriptional regulator
AXE84_RS05840	COG0542	response to heat
AXE84_RS05865	COG0546	phosphoglycolate phosphatase activity
AXE84_RS05870	COG1609	Transcriptional regulator
AXE84_RS05875	COG1621	beta-fructofuranosidase activity
AXE84_RS05890	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXE84_RS05895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXE84_RS05895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXE84_RS05900	COG3715	PTS system
AXE84_RS05905	COG3716	PTS system mannose fructose sorbose family IID component
AXE84_RS05925	COG0561	phosphatase activity
AXE84_RS05950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXE84_RS05980	COG3842	ATPase activity
AXE84_RS06000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE84_RS06005	COG0215	cysteine-tRNA ligase activity
AXE84_RS06010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AXE84_RS06025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXE84_RS06040	COG0459	protein refolding
AXE84_RS06055	COG2205	protein histidine kinase activity
AXE84_RS06060	COG0745	RESPONSE REGULATOR receiver
AXE84_RS06070	COG1842	Phage shock protein A
AXE84_RS06080	COG0519	Catalyzes the synthesis of GMP from XMP
AXE84_RS06085	COG1061	Type III restriction enzyme res subunit
AXE84_RS06110	COG1201	RNA secondary structure unwinding
AXE84_RS06115	COG2252	PERMEase
AXE84_RS06150	COG3103	Sh3 type 3 domain protein
AXE84_RS06150	COG0791	NLP P60 protein
AXE84_RS06150	COG1388	LysM domain
AXE84_RS06165	COG0582	viral genome integration into host DNA
AXE84_RS06195	COG1970	mechanosensitive ion channel activity
AXE84_RS06200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXE84_RS06230	COG1215	transferase activity, transferring glycosyl groups
AXE84_RS06235	COG0640	Transcriptional regulator
AXE84_RS06240	COG2814	Major facilitator Superfamily
AXE84_RS06245	COG1297	OPT oligopeptide transporter protein
AXE84_RS06275	COG0697	spore germination
AXE84_RS06295	COG1335	isochorismatase
AXE84_RS06305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXE84_RS06310	COG0084	hydrolase, TatD family'
AXE84_RS06325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXE84_RS06330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AXE84_RS06335	COG0488	(ABC) transporter
AXE84_RS06375	COG0714	Associated with various cellular activities
AXE84_RS06390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXE84_RS06470	COG1309	transcriptional regulator
AXE84_RS06485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXE84_RS06515	COG1136	(ABC) transporter
AXE84_RS06535	COG0148	phosphopyruvate hydratase activity
AXE84_RS06570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXE84_RS06575	COG0193	aminoacyl-tRNA hydrolase activity
AXE84_RS06580	COG2197	response regulator
AXE84_RS06585	COG4585	Histidine kinase
AXE84_RS06615	COG0444	Belongs to the ABC transporter superfamily
AXE84_RS06620	COG1124	(ABC) transporter
AXE84_RS06630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXE84_RS06650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXE84_RS06655	COG0431	NADPH-dependent FMN reductase
AXE84_RS06675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE84_RS06680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXE84_RS06690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXE84_RS06695	COG0513	Belongs to the DEAD box helicase family
AXE84_RS06715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AXE84_RS06720	COG0406	alpha-ribazole phosphatase activity
AXE84_RS06720	COG0494	nUDIX hydrolase
AXE84_RS06725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AXE84_RS06740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXE84_RS06745	COG0745	RESPONSE REGULATOR receiver
AXE84_RS06755	COG3485	protocatechuate 3,4-dioxygenase
AXE84_RS06760	COG0354	folic acid binding
AXE84_RS06770	COG1490	D-aminoacyl-tRNA deacylase activity
AXE84_RS06785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXE84_RS06890	COG0297	glycogen (starch) synthase activity
AXE84_RS06890	COG0438	transferase activity, transferring glycosyl groups
AXE84_RS06910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXE84_RS06910	COG0574	Belongs to the PEP-utilizing enzyme family
AXE84_RS06920	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AXE84_RS06945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXE84_RS06950	COG0698	ribose 5-phosphate isomerase
AXE84_RS06960	COG0698	ribose 5-phosphate isomerase
AXE84_RS07055	COG0546	phosphoglycolate phosphatase activity
AXE84_RS07060	COG1362	aminopeptidase activity
AXE84_RS07065	COG3012	SEC-C Motif Domain Protein
AXE84_RS07070	COG0604	alcohol dehydrogenase
AXE84_RS07075	COG1733	regulation of RNA biosynthetic process
AXE84_RS07080	COG1902	pentaerythritol trinitrate reductase activity
AXE84_RS07095	COG2267	carboxylic ester hydrolase activity
AXE84_RS07105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXE84_RS07115	COG0601	transmembrane transport
AXE84_RS07120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXE84_RS07160	COG1217	gtp-binding protein TYPA
AXE84_RS07215	COG1053	succinate dehydrogenase
AXE84_RS07225	COG2171	N-acyltransferase activity
AXE84_RS07230	COG0406	alpha-ribazole phosphatase activity
AXE84_RS07250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXE84_RS07255	COG1397	ADP-ribosylglycohydrolase
AXE84_RS07290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AXE84_RS07295	COG2197	response regulator
AXE84_RS07310	COG2235	arginine
AXE84_RS07315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXE84_RS07320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXE84_RS07330	COG0395	ABC-type sugar transport system, permease component
AXE84_RS07335	COG1175	transmembrane transport
AXE84_RS07345	COG5426	von Willebrand factor, type A
AXE84_RS07350	COG1940	carbohydrate kinase activity
AXE84_RS07365	COG4176	ABC-type proline glycine betaine transport system permease component
AXE84_RS07385	COG4948	Mandelate Racemase Muconate Lactonizing
AXE84_RS07390	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AXE84_RS07395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXE84_RS07400	COG1169	isochorismate synthase
AXE84_RS07405	COG2226	methyltransferase
AXE84_RS07410	COG0644	oxidoreductase
AXE84_RS07420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXE84_RS07425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXE84_RS07430	COG0649	NAD binding
AXE84_RS07440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AXE84_RS07445	COG1034	ATP synthesis coupled electron transport
AXE84_RS07450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AXE84_RS07465	COG0713	ATP synthesis coupled electron transport
AXE84_RS07470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AXE84_RS07485	COG0142	geranyltranstransferase activity
AXE84_RS07495	COG2885	chlorophyll binding
AXE84_RS07500	COG2885	chlorophyll binding
AXE84_RS07520	COG0501	Belongs to the peptidase M48B family
AXE84_RS07540	COG2197	response regulator
AXE84_RS07545	COG1666	GTP binding
AXE84_RS07565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXE84_RS07580	COG0424	maF-like protein
AXE84_RS07595	COG0745	RESPONSE REGULATOR receiver
AXE84_RS07600	COG5002	protein histidine kinase activity
AXE84_RS07640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXE84_RS07645	COG1316	TRANSCRIPTIONal
AXE84_RS07670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXE84_RS07680	COG0673	inositol 2-dehydrogenase activity
AXE84_RS07725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXE84_RS07805	COG1216	Glycosyl transferase, family 2
AXE84_RS07805	COG0463	Glycosyl transferase, family 2
AXE84_RS07815	COG0438	transferase activity, transferring glycosyl groups
AXE84_RS07845	COG1482	cell wall glycoprotein biosynthetic process
AXE84_RS07880	COG2835	tetraacyldisaccharide 4'-kinase activity
AXE84_RS07895	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AXE84_RS07900	COG0714	Associated with various cellular activities
AXE84_RS07920	COG0745	RESPONSE REGULATOR receiver
AXE84_RS07925	COG5000	phosphorelay sensor kinase activity
AXE84_RS07925	COG5002	protein histidine kinase activity
AXE84_RS07930	COG5401	PFAM Sporulation and spore germination
AXE84_RS07935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AXE84_RS07945	COG0653	protein targeting
AXE84_RS07985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXE84_RS07990	COG0222	ribosome binding
AXE84_RS08000	COG0085	RNA polymerase activity
AXE84_RS08005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXE84_RS08090	COG0419	ATPase involved in DNA repair
AXE84_RS08095	COG0420	3'-5' exonuclease activity
AXE84_RS08110	COG1968	undecaprenyl-diphosphatase activity
AXE84_RS08120	COG0483	inositol monophosphate 1-phosphatase activity
AXE84_RS08125	COG2249	NAD(P)H dehydrogenase (quinone) activity
AXE84_RS08130	COG2249	NAD(P)H dehydrogenase (quinone) activity
AXE84_RS08150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AXE84_RS08175	COG1140	nitrate reductase beta subunit
AXE84_RS08190	COG0315	cyclic pyranopterin monophosphate synthase activity
AXE84_RS08190	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXE84_RS08200	COG0315	cyclic pyranopterin monophosphate synthase activity
AXE84_RS08210	COG0314	molybdopterin synthase activity
AXE84_RS08220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXE84_RS08250	COG1162	GTPase activity
AXE84_RS08255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXE84_RS08260	COG2838	Isocitrate dehydrogenase
AXE84_RS08270	COG1595	DNA-templated transcription, initiation
AXE84_RS08290	COG0567	Dehydrogenase, E1 component
AXE84_RS08290	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXE84_RS08300	COG1253	flavin adenine dinucleotide binding
AXE84_RS08310	COG0739	heme binding
AXE84_RS08335	COG0018	arginyl-trna synthetase
AXE84_RS08340	COG0019	diaminopimelate decarboxylase activity
AXE84_RS08350	COG0460	homoserine dehydrogenase
AXE84_RS08355	COG0083	homoserine kinase activity
AXE84_RS08360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXE84_RS08365	COG0431	NADPH-dependent FMN reductase
AXE84_RS08375	COG0254	rRNA binding
AXE84_RS08380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXE84_RS08395	COG0604	alcohol dehydrogenase
AXE84_RS08395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AXE84_RS08395	COG3321	synthase
AXE84_RS08395	COG4221	oxidoreductase activity
AXE84_RS08400	COG0693	protein deglycase activity
AXE84_RS08420	COG0110	maltose O-acetyltransferase activity
AXE84_RS08425	COG1501	Belongs to the glycosyl hydrolase 31 family
AXE84_RS08430	COG0366	Alpha amylase catalytic
AXE84_RS08435	COG0778	Nitroreductase
AXE84_RS08455	COG0205	6-phosphofructokinase activity
AXE84_RS08460	COG0045	succinate-CoA ligase (ADP-forming) activity
AXE84_RS08490	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AXE84_RS08495	COG1132	(ABC) transporter
AXE84_RS08505	COG0039	L-malate dehydrogenase activity
AXE84_RS08520	COG0395	ABC-type sugar transport system, permease component
AXE84_RS08555	COG0058	SHG alpha-glucan phosphorylase activity
AXE84_RS08560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AXE84_RS08575	COG0366	Alpha amylase catalytic
AXE84_RS08590	COG2086	electron transfer activity
AXE84_RS08595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AXE84_RS08600	COG0482	sulfurtransferase activity
AXE84_RS08615	COG1104	cysteine desulfurase activity
AXE84_RS08635	COG3480	Lon protease (S16) C-terminal proteolytic domain
AXE84_RS08650	COG1615	UPF0182 protein
AXE84_RS08670	COG2326	polyphosphate kinase activity
AXE84_RS08675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXE84_RS08745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXE84_RS08775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXE84_RS08780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXE84_RS08790	COG2190	(PTS) system
AXE84_RS08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXE84_RS08800	COG2188	Transcriptional regulator
AXE84_RS08805	COG1263	PTS System
AXE84_RS08830	COG3590	peptidase
AXE84_RS08850	COG1045	serine acetyltransferase
AXE84_RS08860	COG1739	Uncharacterized protein family UPF0029
AXE84_RS08880	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXE84_RS08900	COG0740	serine-type endopeptidase activity
AXE84_RS08905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXE84_RS08910	COG1605	Chorismate mutase
AXE84_RS08910	COG0287	Prephenate dehydrogenase
AXE84_RS08940	COG0366	Alpha amylase catalytic
AXE84_RS08945	COG1609	Transcriptional regulator
AXE84_RS08955	COG1222	aaa ATPase
AXE84_RS08960	COG4122	O-methyltransferase activity
AXE84_RS08970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AXE84_RS08980	COG1122	ATPase activity
AXE84_RS08985	COG2375	cellular response to nickel ion
AXE84_RS08985	COG1132	(ABC) transporter
AXE84_RS09015	COG0730	response to heat
AXE84_RS09020	COG1648	precorrin-2 dehydrogenase activity
AXE84_RS09020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXE84_RS09035	COG0175	sulfate reduction
AXE84_RS09040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE84_RS09045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AXE84_RS09050	COG2056	Na+-H+ antiporter family
AXE84_RS09055	COG4221	oxidoreductase activity
AXE84_RS09090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AXE84_RS09095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXE84_RS09100	COG1215	transferase activity, transferring glycosyl groups
AXE84_RS09130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AXE84_RS09135	COG0285	dihydrofolate synthase activity
AXE84_RS09140	COG1461	Dihydroxyacetone kinase
AXE84_RS09145	COG0105	UTP biosynthetic process
AXE84_RS09155	COG4152	abc transporter atp-binding protein
AXE84_RS09160	COG1196	nuclear chromosome segregation
AXE84_RS09175	COG2197	response regulator
AXE84_RS09180	COG4585	Histidine kinase
AXE84_RS09185	COG0842	Transport permease protein
AXE84_RS09190	COG1131	(ABC) transporter
AXE84_RS09205	COG2197	response regulator
AXE84_RS09210	COG4585	Histidine kinase
AXE84_RS09235	COG1837	Belongs to the UPF0109 family
AXE84_RS09240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXE84_RS09250	COG0681	Belongs to the peptidase S26 family
AXE84_RS09260	COG0681	Belongs to the peptidase S26 family
AXE84_RS09265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXE84_RS09275	COG0792	nuclease activity
AXE84_RS09295	COG1716	ATPase activity
AXE84_RS09305	COG4974	Belongs to the 'phage' integrase family
AXE84_RS09315	COG0052	Belongs to the universal ribosomal protein uS2 family
AXE84_RS09320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXE84_RS09330	COG0233	cytoplasmic translational termination
AXE84_RS09340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXE84_RS09350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AXE84_RS09355	COG0750	zinc metalloprotease
AXE84_RS09360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AXE84_RS09365	COG0456	acetyltransferase
AXE84_RS09400	COG0442	prolyl-tRNA aminoacylation
AXE84_RS09430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXE84_RS09435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AXE84_RS09450	COG0330	HflC and HflK could
AXE84_RS09460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXE84_RS09465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXE84_RS09475	COG1136	(ABC) transporter
AXE84_RS09475	COG0577	efflux transmembrane transporter activity
AXE84_RS09485	COG0196	riboflavin kinase activity
AXE84_RS09500	COG1185	polyribonucleotide nucleotidyltransferase activity
AXE84_RS09505	COG0612	Peptidase, M16
AXE84_RS09510	COG0300	oxidoreductase activity
AXE84_RS09515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXE84_RS09535	COG0318	PFAM AMP-dependent synthetase and ligase
AXE84_RS09540	COG0318	PFAM AMP-dependent synthetase and ligase
AXE84_RS09560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXE84_RS09570	COG2001	Belongs to the MraZ family
AXE84_RS09575	COG0275	rRNA processing
AXE84_RS09585	COG0768	penicillin binding
AXE84_RS09590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AXE84_RS09595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXE84_RS09600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXE84_RS09605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXE84_RS09620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXE84_RS09630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AXE84_RS09635	COG1496	oxidoreductase activity
AXE84_RS09640	COG1799	cell septum assembly
AXE84_RS09655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AXE84_RS09670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AXE84_RS09675	COG0587	DNA-directed DNA polymerase activity
AXE84_RS09680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXE84_RS09685	COG2501	S4 domain
AXE84_RS09705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXE84_RS09710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXE84_RS09720	COG1215	transferase activity, transferring glycosyl groups
AXE84_RS09730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXE84_RS09750	COG0025	NhaP-type Na H and K H
AXE84_RS09760	COG0131	Imidazoleglycerol-phosphate dehydratase
AXE84_RS09775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXE84_RS09780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXE84_RS09790	COG0575	Belongs to the CDS family
AXE84_RS09810	COG4133	protoheme IX ABC transporter activity
AXE84_RS09820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXE84_RS09825	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXE84_RS09830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXE84_RS09835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE84_RS09850	COG1126	abc transporter atp-binding protein
AXE84_RS09855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXE84_RS09860	COG0765	amino acid transport
AXE84_RS09865	COG0765	amino acid transport
AXE84_RS09885	COG1131	(ABC) transporter
AXE84_RS09895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXE84_RS09910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXE84_RS09920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXE84_RS09925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXE84_RS09930	COG1438	arginine binding
AXE84_RS09935	COG0137	argininosuccinate synthase activity
AXE84_RS09940	COG2116	formate transmembrane transporter activity
AXE84_RS09945	COG0165	Argininosuccinate lyase
AXE84_RS09950	COG2094	Belongs to the DNA glycosylase MPG family
AXE84_RS09970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXE84_RS10000	COG0647	UMP catabolic process
AXE84_RS10015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXE84_RS10020	COG0497	DNA recombination
AXE84_RS10050	COG0494	nUDIX hydrolase
AXE84_RS10055	COG1609	Transcriptional regulator
AXE84_RS10065	COG1175	transmembrane transport
AXE84_RS10070	COG0395	ABC-type sugar transport system, permease component
AXE84_RS10075	COG1621	beta-fructofuranosidase activity
AXE84_RS10095	COG0719	Fe-S assembly protein
AXE84_RS10100	COG0396	ATPase activity
AXE84_RS10110	COG0822	iron-sulfur transferase activity
AXE84_RS10115	COG2151	metal-sulfur cluster biosynthetic enzyme
AXE84_RS10120	COG3189	MarR family transcriptional regulator
AXE84_RS10125	COG1309	transcriptional regulator
AXE84_RS10145	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AXE84_RS10160	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AXE84_RS10180	COG0167	dihydroorotate dehydrogenase activity
AXE84_RS10205	COG3833	ABC-type maltose transport systems, permease component
AXE84_RS10210	COG1175	transmembrane transport
AXE84_RS10215	COG2182	Extracellular solute-binding protein
AXE84_RS10230	COG0358	DNA primase activity
AXE84_RS10265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXE84_RS10270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXE84_RS10280	COG1027	Aspartate ammonia-lyase
AXE84_RS10290	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AXE84_RS10305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AXE84_RS10310	COG0483	inositol monophosphate 1-phosphatase activity
AXE84_RS10330	COG0436	Aminotransferase
AXE84_RS10345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXE84_RS10355	COG3022	response to hydroperoxide
AXE84_RS10375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AXE84_RS10380	COG0174	glutamine synthetase
AXE84_RS10385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AXE84_RS10390	COG0406	alpha-ribazole phosphatase activity
AXE84_RS10400	COG0765	amino acid transport
AXE84_RS10420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXE84_RS10425	COG0321	lipoyl(octanoyl) transferase activity
AXE84_RS10450	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXE84_RS10455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXE84_RS10460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AXE84_RS10470	COG0038	chloride channel
AXE84_RS10475	COG1073	alpha beta
AXE84_RS10485	COG1882	Formate acetyltransferase
AXE84_RS10545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXE84_RS10565	COG0438	transferase activity, transferring glycosyl groups
AXE84_RS10580	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AXE84_RS10585	COG1051	belongs to the nudix hydrolase family
AXE84_RS10590	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AXE84_RS10595	COG0217	transcriptional regulatory protein
AXE84_RS10600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXE84_RS10605	COG0632	four-way junction helicase activity
AXE84_RS10610	COG2255	four-way junction helicase activity
AXE84_RS10620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXE84_RS10625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXE84_RS10630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXE84_RS10635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXE84_RS10645	COG0789	Transcriptional regulator
AXE84_RS10655	COG1196	nuclear chromosome segregation
AXE84_RS10670	COG0124	histidyl-tRNA synthetase
AXE84_RS10680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXE84_RS10700	COG1116	anion transmembrane transporter activity
AXE84_RS10700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXE84_RS10730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXE84_RS10760	COG0009	L-threonylcarbamoyladenylate synthase
AXE84_RS10770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXE84_RS10775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXE84_RS10780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXE84_RS10795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXE84_RS10805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AXE84_RS10810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXE84_RS10815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXE84_RS10840	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AXE84_RS10845	COG0540	Belongs to the ATCase OTCase family
AXE84_RS10850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXE84_RS10860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AXE84_RS10865	COG0284	orotidine-5'-phosphate decarboxylase activity
AXE84_RS10875	COG0194	GDP metabolic process
AXE84_RS10880	COG1758	RNA polymerase activity
AXE84_RS10890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXE84_RS10915	COG1834	amidinotransferase
AXE84_RS10920	COG0549	Belongs to the carbamate kinase family
AXE84_RS10925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXE84_RS10940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXE84_RS10950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXE84_RS10955	COG4770	biotin carboxylase activity
AXE84_RS10960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXE84_RS10965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXE84_RS10970	COG0736	holo-[acyl-carrier-protein] synthase activity
AXE84_RS10975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXE84_RS10980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXE84_RS10985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXE84_RS10990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXE84_RS10995	COG0140	phosphoribosyl-ATP diphosphatase activity
AXE84_RS11015	COG1131	(ABC) transporter
AXE84_RS11020	COG2197	response regulator
AXE84_RS11025	COG4585	Histidine kinase
AXE84_RS11045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXE84_RS11050	COG0805	protein transport
AXE84_RS11065	COG2354	Protein conserved in bacteria
AXE84_RS11070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AXE84_RS11085	COG0205	6-phosphofructokinase activity
AXE84_RS11095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXE84_RS11100	COG0577	efflux transmembrane transporter activity
AXE84_RS11105	COG1136	(ABC) transporter
AXE84_RS11115	COG1609	Transcriptional regulator
AXE84_RS11120	COG1263	PTS System
AXE84_RS11120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXE84_RS11120	COG2190	(PTS) system
AXE84_RS11125	COG1621	beta-fructofuranosidase activity
AXE84_RS11140	COG0443	Heat shock 70 kDa protein
AXE84_RS11145	COG0667	Aldo Keto reductase
AXE84_RS11165	COG1716	ATPase activity
AXE84_RS11175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AXE84_RS11190	COG0363	glucosamine-6-phosphate deaminase activity
AXE84_RS11220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXE84_RS11225	COG0166	Belongs to the GPI family
AXE84_RS11235	COG1160	GTP binding
AXE84_RS11250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AXE84_RS11270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXE84_RS11275	COG0149	triose-phosphate isomerase activity
AXE84_RS11280	COG0126	phosphoglycerate kinase activity
AXE84_RS11285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AXE84_RS11290	COG1481	regulation of sporulation
AXE84_RS11300	COG1660	Displays ATPase and GTPase activities
AXE84_RS11305	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AXE84_RS11315	COG3585	molybdate ion transport
AXE84_RS11320	COG0322	excinuclease ABC activity
AXE84_RS11375	COG0556	nucleotide-excision repair
AXE84_RS11380	COG0237	dephospho-CoA kinase activity
AXE84_RS11390	COG0539	negative regulation of cytoplasmic translation
AXE84_RS11400	COG2050	protein possibly involved in aromatic compounds catabolism
AXE84_RS11425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AXE84_RS11430	COG0134	indole-3-glycerol-phosphate synthase activity
AXE84_RS11450	COG0107	imidazoleglycerol-phosphate synthase activity
AXE84_RS11460	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AXE84_RS11470	COG4122	O-methyltransferase activity
AXE84_RS11475	COG1222	aaa ATPase
AXE84_RS11490	COG2837	iron assimilation
AXE84_RS11495	COG1994	Peptidase M50
AXE84_RS11495	COG0517	IMP dehydrogenase activity
AXE84_RS11505	COG2391	methyltransferase activity
AXE84_RS11510	COG0425	Belongs to the sulfur carrier protein TusA family
AXE84_RS11515	COG0667	Aldo Keto reductase
AXE84_RS11520	COG4604	ABC transporter, ATP-binding protein
AXE84_RS11525	COG4605	iron ion homeostasis
AXE84_RS11530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXE84_RS11535	COG4607	ABC-type enterochelin transport system periplasmic component
AXE84_RS11545	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXE84_RS11550	COG0339	signal peptide processing
AXE84_RS11560	COG0477	Major facilitator Superfamily
AXE84_RS11600	COG0587	DNA-directed DNA polymerase activity
AXE84_RS11620	COG1435	thymidine kinase activity
AXE84_RS11625	COG0671	phosphoesterase, PA-phosphatase related
AXE84_RS11640	COG1881	PFAM PEBP family protein
AXE84_RS11645	COG4221	oxidoreductase activity
AXE84_RS11650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXE84_RS11665	COG4555	ABC transporter
AXE84_RS11680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXE84_RS11685	COG1309	transcriptional regulator
AXE84_RS11695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXE84_RS11700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXE84_RS11705	COG0531	amino acid
AXE84_RS11710	COG0569	domain protein
AXE84_RS11755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXE84_RS11770	COG0187	DNA topoisomerase II activity
AXE84_RS11790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXE84_RS11795	COG0142	geranyltranstransferase activity
AXE84_RS11800	COG0515	serine threonine protein kinase
AXE84_RS11800	COG2815	serine threonine protein kinase
AXE84_RS11805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AXE84_RS11810	COG0205	6-phosphofructokinase activity
AXE84_RS11845	COG0545	Peptidyl-prolyl cis-trans isomerase
AXE84_RS11855	COG0488	(ABC) transporter
AXE84_RS11885	COG1119	ATPase activity
AXE84_RS11895	COG0297	glycogen (starch) synthase activity
AXE84_RS11905	COG0560	Phosphoserine phosphatase
AXE84_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
AXE84_RS11930	COG0423	glycine-tRNA ligase activity
AXE84_RS11945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXE84_RS11955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXE84_RS11960	COG1381	Involved in DNA repair and RecF pathway recombination
AXE84_RS11965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXE84_RS11980	COG1476	TRANSCRIPTIONal
AXE84_RS11985	COG2337	Toxic component of a toxin-antitoxin (TA) module
AXE84_RS11990	COG3609	addiction module antidote protein, CC2985 family
AXE84_RS11995	COG0506	proline dehydrogenase activity
AXE84_RS11995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXE84_RS11995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXE84_RS12000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXE84_RS12010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXE84_RS12030	COG0842	Transport permease protein
AXE84_RS12040	COG1309	transcriptional regulator
AXE84_RS12050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXE84_RS12055	COG0484	heat shock protein binding
AXE84_RS12060	COG1420	regulation of RNA biosynthetic process
AXE84_RS12075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXE84_RS12095	COG2807	transmembrane transport
AXE84_RS12100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AXE84_RS12110	COG0481	GTPase activity
AXE84_RS12120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXE84_RS12125	COG0512	Glutamine amidotransferase of anthranilate synthase
AXE84_RS12140	COG0159	tryptophan synthase activity
AXE84_RS12160	COG0268	Binds directly to 16S ribosomal RNA
AXE84_RS12165	COG4868	Belongs to the UPF0371 family
AXE84_RS12180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXE84_RS12180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXE84_RS12185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXE84_RS12210	COG0438	transferase activity, transferring glycosyl groups
AXE84_RS12215	COG0433	COG0433 Predicted ATPase
AXE84_RS12220	COG0495	leucyl-tRNA aminoacylation
AXE84_RS12230	COG0537	adenosine 5'-monophosphoramidase activity
AXE84_RS12255	COG0733	neurotransmitter:sodium symporter activity
AXE84_RS12275	COG2095	MarC family integral membrane protein
AXE84_RS12290	COG0406	alpha-ribazole phosphatase activity
AXE84_RS12295	COG0799	negative regulation of ribosome biogenesis