locus-tag	class	description
AXF14_RS00005	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS00045	COG3328	transposase activity
AXF14_RS00055	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AXF14_RS00060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXF14_RS00085	COG1234	tRNA 3'-trailer cleavage
AXF14_RS00090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXF14_RS00100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AXF14_RS00120	COG0363	glucosamine-6-phosphate deaminase activity
AXF14_RS00145	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AXF14_RS00155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXF14_RS00160	COG4608	Belongs to the ABC transporter superfamily
AXF14_RS00165	COG0444	Belongs to the ABC transporter superfamily
AXF14_RS00175	COG0747	negative chemotaxis
AXF14_RS00180	COG2186	Transcriptional regulator
AXF14_RS00185	COG2233	PERMEase
AXF14_RS00200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXF14_RS00210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXF14_RS00235	COG0739	heme binding
AXF14_RS00240	COG2177	Part of the ABC transporter FtsEX involved in
AXF14_RS00245	COG2884	Cell division ATP-binding protein ftsE
AXF14_RS00270	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS00295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AXF14_RS00315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXF14_RS00320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXF14_RS00325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXF14_RS00350	COG0473	3-isopropylmalate dehydrogenase activity
AXF14_RS00355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXF14_RS00360	COG0440	acetolactate synthase activity
AXF14_RS00370	COG2985	domain, Protein
AXF14_RS00370	COG0569	domain protein
AXF14_RS00410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXF14_RS00415	COG0154	amidase activity
AXF14_RS00420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXF14_RS00430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXF14_RS00440	COG1674	ftsk spoiiie
AXF14_RS00470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXF14_RS00490	COG1174	glycine betaine transport
AXF14_RS00495	COG1174	glycine betaine transport
AXF14_RS00500	COG1125	glycine betaine transport
AXF14_RS00500	COG0517	IMP dehydrogenase activity
AXF14_RS00515	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS00535	COG1064	alcohol dehydrogenase
AXF14_RS00560	COG0114	fumarate hydratase activity
AXF14_RS00565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AXF14_RS00620	COG2837	iron assimilation
AXF14_RS00640	COG1473	amidohydrolase
AXF14_RS00655	COG0714	Associated with various cellular activities
AXF14_RS00695	COG4555	ABC transporter
AXF14_RS00720	COG0604	alcohol dehydrogenase
AXF14_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
AXF14_RS00720	COG3321	synthase
AXF14_RS00735	COG1615	UPF0182 protein
AXF14_RS00785	COG0482	sulfurtransferase activity
AXF14_RS00800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AXF14_RS00805	COG2086	electron transfer activity
AXF14_RS00815	COG0180	Tryptophanyl-tRNA synthetase
AXF14_RS00820	COG0366	Alpha amylase catalytic
AXF14_RS00830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AXF14_RS00835	COG0058	SHG alpha-glucan phosphorylase activity
AXF14_RS00860	COG1725	Transcriptional regulator
AXF14_RS00875	COG3833	ABC-type maltose transport systems, permease component
AXF14_RS00890	COG0039	L-malate dehydrogenase activity
AXF14_RS00935	COG0045	succinate-CoA ligase (ADP-forming) activity
AXF14_RS00950	COG0366	Alpha amylase catalytic
AXF14_RS00955	COG1012	belongs to the aldehyde dehydrogenase family
AXF14_RS00965	COG1175	transmembrane transport
AXF14_RS00970	COG1653	transport
AXF14_RS00980	COG3415	Transposase
AXF14_RS00980	COG2801	Transposase and inactivated derivatives
AXF14_RS00985	COG1501	Belongs to the glycosyl hydrolase 31 family
AXF14_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
AXF14_RS00995	COG1609	Transcriptional regulator
AXF14_RS01000	COG0366	Alpha amylase catalytic
AXF14_RS01015	COG1653	transport
AXF14_RS01020	COG1472	Belongs to the glycosyl hydrolase 3 family
AXF14_RS01070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXF14_RS01075	COG0254	rRNA binding
AXF14_RS01090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXF14_RS01100	COG0083	homoserine kinase activity
AXF14_RS01105	COG0460	homoserine dehydrogenase
AXF14_RS01115	COG1122	ATPase activity
AXF14_RS01130	COG3415	Transposase
AXF14_RS01130	COG2801	Transposase and inactivated derivatives
AXF14_RS01145	COG1132	(ABC) transporter
AXF14_RS01150	COG0019	diaminopimelate decarboxylase activity
AXF14_RS01155	COG0018	arginyl-trna synthetase
AXF14_RS01170	COG0584	glycerophosphoryl diester phosphodiesterase
AXF14_RS01175	COG0739	heme binding
AXF14_RS01190	COG0567	Dehydrogenase, E1 component
AXF14_RS01190	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXF14_RS01205	COG5662	AntiSigma factor
AXF14_RS01210	COG1595	DNA-templated transcription, initiation
AXF14_RS01230	COG0577	efflux transmembrane transporter activity
AXF14_RS01230	COG1136	(ABC) transporter
AXF14_RS01235	COG2838	Isocitrate dehydrogenase
AXF14_RS01240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXF14_RS01245	COG1162	GTPase activity
AXF14_RS01275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXF14_RS01295	COG0315	cyclic pyranopterin monophosphate synthase activity
AXF14_RS01305	COG0315	cyclic pyranopterin monophosphate synthase activity
AXF14_RS01305	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXF14_RS01320	COG1140	nitrate reductase beta subunit
AXF14_RS01345	COG1063	alcohol dehydrogenase
AXF14_RS01350	COG3415	Transposase
AXF14_RS01350	COG2801	Transposase and inactivated derivatives
AXF14_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
AXF14_RS01375	COG0483	inositol monophosphate 1-phosphatase activity
AXF14_RS01380	COG1968	undecaprenyl-diphosphatase activity
AXF14_RS01385	COG0420	3'-5' exonuclease activity
AXF14_RS01390	COG0419	ATPase involved in DNA repair
AXF14_RS01430	COG0653	protein targeting
AXF14_RS01440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AXF14_RS01445	COG5401	PFAM Sporulation and spore germination
AXF14_RS01450	COG5002	protein histidine kinase activity
AXF14_RS01450	COG5000	phosphorelay sensor kinase activity
AXF14_RS01455	COG0745	RESPONSE REGULATOR receiver
AXF14_RS01475	COG0714	Associated with various cellular activities
AXF14_RS01480	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AXF14_RS01530	COG1482	cell wall glycoprotein biosynthetic process
AXF14_RS01540	COG4750	Nucleotidyl transferase
AXF14_RS01545	COG0697	spore germination
AXF14_RS01550	COG3475	LICD family
AXF14_RS01565	COG1216	Glycosyl transferase, family 2
AXF14_RS01570	COG3475	LICD family
AXF14_RS01620	COG0438	transferase activity, transferring glycosyl groups
AXF14_RS01630	COG0438	transferase activity, transferring glycosyl groups
AXF14_RS01630	COG1216	Glycosyl transferase, family 2
AXF14_RS01655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXF14_RS01665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXF14_RS01680	COG0438	transferase activity, transferring glycosyl groups
AXF14_RS01725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXF14_RS01745	COG1316	TRANSCRIPTIONal
AXF14_RS01750	COG1316	TRANSCRIPTIONal
AXF14_RS01755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXF14_RS01760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AXF14_RS01785	COG5002	protein histidine kinase activity
AXF14_RS01790	COG0745	RESPONSE REGULATOR receiver
AXF14_RS01805	COG0424	maF-like protein
AXF14_RS01810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXF14_RS01825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXF14_RS01845	COG1666	GTP binding
AXF14_RS01850	COG0501	Belongs to the peptidase M48B family
AXF14_RS01855	COG0456	acetyltransferase
AXF14_RS01855	COG0454	-acetyltransferase
AXF14_RS01875	COG0142	geranyltranstransferase activity
AXF14_RS01880	COG1007	ATP synthesis coupled electron transport
AXF14_RS01890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AXF14_RS01895	COG0713	ATP synthesis coupled electron transport
AXF14_RS01905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXF14_RS01910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AXF14_RS01915	COG1034	ATP synthesis coupled electron transport
AXF14_RS01920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AXF14_RS01930	COG0649	NAD binding
AXF14_RS01935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXF14_RS01940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXF14_RS01955	COG2226	methyltransferase
AXF14_RS01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXF14_RS01975	COG2801	Transposase and inactivated derivatives
AXF14_RS02030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AXF14_RS02035	COG4948	Mandelate Racemase Muconate Lactonizing
AXF14_RS02040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXF14_RS02095	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AXF14_RS02095	COG0028	Belongs to the TPP enzyme family
AXF14_RS02100	COG1012	belongs to the aldehyde dehydrogenase family
AXF14_RS02115	COG2801	Transposase and inactivated derivatives
AXF14_RS02135	COG2963	transposase activity
AXF14_RS02140	COG2235	arginine
AXF14_RS02160	COG2197	response regulator
AXF14_RS02165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AXF14_RS02190	COG3477	response to acidic pH
AXF14_RS02215	COG0406	alpha-ribazole phosphatase activity
AXF14_RS02230	COG1053	succinate dehydrogenase
AXF14_RS02280	COG1217	gtp-binding protein TYPA
AXF14_RS02290	COG0747	negative chemotaxis
AXF14_RS02300	COG0747	negative chemotaxis
AXF14_RS02325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXF14_RS02330	COG0601	transmembrane transport
AXF14_RS02340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXF14_RS02345	COG0385	Bile acid
AXF14_RS02370	COG2514	catechol 2,3-dioxygenase activity
AXF14_RS02375	COG4667	esterase of the alpha-beta hydrolase superfamily
AXF14_RS02380	COG1902	pentaerythritol trinitrate reductase activity
AXF14_RS02385	COG3012	SEC-C Motif Domain Protein
AXF14_RS02390	COG1362	aminopeptidase activity
AXF14_RS02440	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS02480	COG0789	Transcriptional regulator
AXF14_RS02540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXF14_RS02555	COG1278	Cold shock
AXF14_RS02590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXF14_RS02605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXF14_RS02615	COG0656	L-ascorbic acid biosynthetic process
AXF14_RS02620	COG1090	epimerase
AXF14_RS02625	COG0436	Aminotransferase
AXF14_RS02630	COG3328	transposase activity
AXF14_RS02640	COG0012	GTP binding
AXF14_RS02665	COG1322	Protein conserved in bacteria
AXF14_RS02675	COG1570	exodeoxyribonuclease VII activity
AXF14_RS02680	COG1609	Transcriptional regulator
AXF14_RS02690	COG1621	beta-fructofuranosidase activity
AXF14_RS02695	COG1722	exodeoxyribonuclease VII activity
AXF14_RS02705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXF14_RS02715	COG2326	polyphosphate kinase activity
AXF14_RS02720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXF14_RS02745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXF14_RS02755	COG1279	arginine transmembrane transporter activity
AXF14_RS02760	COG0583	DNA-binding transcription factor activity
AXF14_RS02780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXF14_RS02785	COG0129	dihydroxy-acid dehydratase activity
AXF14_RS02815	COG2197	response regulator
AXF14_RS02820	COG0193	aminoacyl-tRNA hydrolase activity
AXF14_RS02825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXF14_RS02855	COG0148	phosphopyruvate hydratase activity
AXF14_RS02885	COG3415	Transposase
AXF14_RS02885	COG2801	Transposase and inactivated derivatives
AXF14_RS02890	COG2244	polysaccharide biosynthetic process
AXF14_RS02950	COG0297	glycogen (starch) synthase activity
AXF14_RS02960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXF14_RS02975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXF14_RS02985	COG1309	transcriptional regulator
AXF14_RS02995	COG0488	(ABC) transporter
AXF14_RS03000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AXF14_RS03005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXF14_RS03025	COG0084	hydrolase, TatD family'
AXF14_RS03030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXF14_RS03045	COG1335	isochorismatase
AXF14_RS03095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXF14_RS03105	COG1970	mechanosensitive ion channel activity
AXF14_RS03135	COG1388	LysM domain
AXF14_RS03135	COG3103	Sh3 type 3 domain protein
AXF14_RS03135	COG0791	NLP P60 protein
AXF14_RS03155	COG2252	PERMEase
AXF14_RS03160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXF14_RS03180	COG1061	Type III restriction enzyme res subunit
AXF14_RS03205	COG1842	Phage shock protein A
AXF14_RS03215	COG0745	RESPONSE REGULATOR receiver
AXF14_RS03220	COG2205	protein histidine kinase activity
AXF14_RS03235	COG0459	protein refolding
AXF14_RS03250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXF14_RS03275	COG3842	ATPase activity
AXF14_RS03295	COG0215	cysteine-tRNA ligase activity
AXF14_RS03300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXF14_RS03305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXF14_RS03315	COG2801	Transposase and inactivated derivatives
AXF14_RS03315	COG3415	Transposase
AXF14_RS03340	COG3716	PTS system mannose fructose sorbose family IID component
AXF14_RS03345	COG3715	PTS system
AXF14_RS03350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXF14_RS03350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXF14_RS03360	COG0561	phosphatase activity
AXF14_RS03375	COG1621	beta-fructofuranosidase activity
AXF14_RS03390	COG2272	Belongs to the type-B carboxylesterase lipase family
AXF14_RS03410	COG0577	efflux transmembrane transporter activity
AXF14_RS03430	COG0745	RESPONSE REGULATOR receiver
AXF14_RS03435	COG2205	protein histidine kinase activity
AXF14_RS03440	COG0789	Transcriptional regulator
AXF14_RS03445	COG2963	transposase activity
AXF14_RS03455	COG2353	YceI-like domain
AXF14_RS03460	COG1505	serine-type exopeptidase activity
AXF14_RS03475	COG0789	Transcriptional regulator
AXF14_RS03480	COG0484	heat shock protein binding
AXF14_RS03485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXF14_RS03495	COG0443	Heat shock 70 kDa protein
AXF14_RS03505	COG1136	(ABC) transporter
AXF14_RS03505	COG0577	efflux transmembrane transporter activity
AXF14_RS03565	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS03590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXF14_RS03600	COG1131	(ABC) transporter
AXF14_RS03665	COG2814	Major facilitator Superfamily
AXF14_RS03690	COG0778	Nitroreductase
AXF14_RS03710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AXF14_RS03715	COG0738	Major facilitator superfamily
AXF14_RS03725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXF14_RS03740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AXF14_RS03745	COG0471	metal ion transport
AXF14_RS03750	COG1569	PIN domain
AXF14_RS03755	COG3311	Transcriptional regulator
AXF14_RS03780	COG1205	dead DEAH box helicase
AXF14_RS03780	COG1111	helicase
AXF14_RS03810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AXF14_RS03820	COG0475	glutathione-regulated potassium exporter activity
AXF14_RS03875	COG0601	transmembrane transport
AXF14_RS03880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXF14_RS03910	COG3842	ATPase activity
AXF14_RS03915	COG1175	transmembrane transport
AXF14_RS03935	COG2181	nitrate reductase activity
AXF14_RS03935	COG0247	lactate metabolic process
AXF14_RS03945	COG2364	Membrane
AXF14_RS03960	COG2382	esterase
AXF14_RS03965	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AXF14_RS03970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXF14_RS03980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXF14_RS03990	COG3386	PFAM SMP-30 Gluconolaconase
AXF14_RS04010	COG2375	cellular response to nickel ion
AXF14_RS04010	COG1132	(ABC) transporter
AXF14_RS04015	COG1132	(ABC) transporter
AXF14_RS04020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AXF14_RS04025	COG0626	cystathionine gamma-synthase activity
AXF14_RS04040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXF14_RS04050	COG3328	transposase activity
AXF14_RS04065	COG0471	metal ion transport
AXF14_RS04080	COG1653	transport
AXF14_RS04085	COG0561	phosphatase activity
AXF14_RS04090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXF14_RS04100	COG1597	lipid kinase activity
AXF14_RS04155	COG2814	Major facilitator Superfamily
AXF14_RS04175	COG0534	Mate efflux family protein
AXF14_RS04200	COG3588	fructose-bisphosphate aldolase
AXF14_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
AXF14_RS04245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXF14_RS04250	COG1950	PFAM Membrane protein of
AXF14_RS04265	COG3559	Exporter of polyketide antibiotics
AXF14_RS04270	COG1131	(ABC) transporter
AXF14_RS04280	COG2813	Specifically methylates the guanine in position
AXF14_RS04285	COG3579	cysteine-type endopeptidase activity
AXF14_RS04300	COG1937	Protein conserved in bacteria
AXF14_RS04320	COG2801	Transposase and inactivated derivatives
AXF14_RS04320	COG3415	Transposase
AXF14_RS04330	COG1215	transferase activity, transferring glycosyl groups
AXF14_RS04345	COG1131	(ABC) transporter
AXF14_RS04365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AXF14_RS04370	COG1454	alcohol dehydrogenase
AXF14_RS04380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXF14_RS04395	COG0483	inositol monophosphate 1-phosphatase activity
AXF14_RS04400	COG1063	alcohol dehydrogenase
AXF14_RS04405	COG0156	8-amino-7-oxononanoate synthase activity
AXF14_RS04415	COG3328	transposase activity
AXF14_RS04420	COG1113	amino acid transport
AXF14_RS04430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXF14_RS04435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXF14_RS04440	COG1940	carbohydrate kinase activity
AXF14_RS04445	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AXF14_RS04450	COG0628	permease
AXF14_RS04455	COG0390	transport system, permease component
AXF14_RS04465	COG2197	response regulator
AXF14_RS04480	COG2197	response regulator
AXF14_RS04495	COG1854	S-ribosylhomocysteine lyase activity
AXF14_RS04515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AXF14_RS04540	COG2409	Drug exporters of the RND superfamily
AXF14_RS04550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AXF14_RS04560	COG2985	domain, Protein
AXF14_RS04560	COG0569	domain protein
AXF14_RS04565	COG1428	Deoxynucleoside kinase
AXF14_RS04570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AXF14_RS04575	COG1966	Carbon starvation protein
AXF14_RS04585	COG0535	radical SAM domain protein
AXF14_RS04600	COG1716	ATPase activity
AXF14_RS04605	COG1716	ATPase activity
AXF14_RS04620	COG0768	penicillin binding
AXF14_RS04625	COG0515	serine threonine protein kinase
AXF14_RS04630	COG0515	serine threonine protein kinase
AXF14_RS04635	COG3764	Sortase (surface protein transpeptidase)
AXF14_RS04645	COG0656	L-ascorbic acid biosynthetic process
AXF14_RS04680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXF14_RS04685	COG0187	DNA topoisomerase II activity
AXF14_RS04690	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AXF14_RS04695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXF14_RS04700	COG0592	DNA-directed DNA polymerase activity
AXF14_RS04705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXF14_RS04710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AXF14_RS04715	COG0594	ribonuclease P activity
AXF14_RS04720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AXF14_RS04725	COG0706	membrane insertase activity
AXF14_RS04735	COG0357	Ribosomal RNA small subunit methyltransferase G
AXF14_RS04755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXF14_RS04760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXF14_RS04765	COG0110	maltose O-acetyltransferase activity
AXF14_RS04770	COG3118	belongs to the thioredoxin family
AXF14_RS04775	COG0492	ferredoxin-NADP+ reductase activity
AXF14_RS04795	COG0617	tRNA 3'-terminal CCA addition
AXF14_RS04800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AXF14_RS04805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXF14_RS04820	COG0789	Transcriptional regulator
AXF14_RS04830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXF14_RS04835	COG0360	Binds together with S18 to 16S ribosomal RNA
AXF14_RS04840	COG0629	single-stranded DNA binding
AXF14_RS04845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXF14_RS04850	COG0359	binds to the 23S rRNA
AXF14_RS04860	COG0305	Participates in initiation and elongation during chromosome replication
AXF14_RS04865	COG0351	phosphomethylpyrimidine kinase
AXF14_RS04880	COG1760	l-serine dehydratase
AXF14_RS04890	COG3550	peptidyl-serine autophosphorylation
AXF14_RS04905	COG4115	mRNA cleavage
AXF14_RS04910	COG2161	toxin-antitoxin pair type II binding
AXF14_RS04915	COG0366	Alpha amylase catalytic
AXF14_RS04940	COG3328	transposase activity
AXF14_RS04945	COG1136	(ABC) transporter
AXF14_RS04945	COG0577	efflux transmembrane transporter activity
AXF14_RS04965	COG2197	response regulator
AXF14_RS04975	COG3328	transposase activity
AXF14_RS04990	COG1780	Probably involved in ribonucleotide reductase function
AXF14_RS04995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXF14_RS05015	COG3527	Alpha-acetolactate decarboxylase
AXF14_RS05030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXF14_RS05040	COG1737	Transcriptional regulator
AXF14_RS05045	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AXF14_RS05060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXF14_RS05085	COG0798	PFAM Bile acid sodium symporter
AXF14_RS05090	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXF14_RS05110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXF14_RS05135	COG1404	Belongs to the peptidase S8 family
AXF14_RS05150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXF14_RS05155	COG2011	ABC-type metal ion transport system permease component
AXF14_RS05165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AXF14_RS05170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXF14_RS05180	COG0110	maltose O-acetyltransferase activity
AXF14_RS05210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AXF14_RS05215	COG1643	Atp-dependent helicase
AXF14_RS05260	COG2233	PERMEase
AXF14_RS05295	COG2376	Dihydroxyacetone kinase
AXF14_RS05300	COG1461	Dihydroxyacetone kinase
AXF14_RS05305	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AXF14_RS05305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXF14_RS05305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXF14_RS05335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXF14_RS05355	COG1396	sequence-specific DNA binding
AXF14_RS05360	COG0281	malic enzyme
AXF14_RS05365	COG0738	Major facilitator superfamily
AXF14_RS05370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXF14_RS05385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXF14_RS05390	COG0113	porphobilinogen synthase activity
AXF14_RS05400	COG0181	hydroxymethylbilane synthase activity
AXF14_RS05410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXF14_RS05415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXF14_RS05420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXF14_RS05425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXF14_RS05425	COG3253	May function as heme-dependent peroxidase
AXF14_RS05445	COG1051	belongs to the nudix hydrolase family
AXF14_RS05460	COG1597	lipid kinase activity
AXF14_RS05470	COG1408	metallophosphoesterase
AXF14_RS05475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXF14_RS05495	COG0596	Alpha beta hydrolase
AXF14_RS05505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AXF14_RS05520	COG3415	Transposase
AXF14_RS05520	COG2801	Transposase and inactivated derivatives
AXF14_RS05575	COG0450	alkyl hydroperoxide reductase
AXF14_RS05590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXF14_RS05610	COG2890	protein-(glutamine-N5) methyltransferase activity
AXF14_RS05635	COG2205	protein histidine kinase activity
AXF14_RS05640	COG3415	Transposase
AXF14_RS05640	COG2801	Transposase and inactivated derivatives
AXF14_RS05645	COG0745	RESPONSE REGULATOR receiver
AXF14_RS05650	COG3328	transposase activity
AXF14_RS05655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXF14_RS05665	COG1754	DNA topoisomerase type I activity
AXF14_RS05665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXF14_RS05670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AXF14_RS05675	COG0470	DNA polymerase III
AXF14_RS05685	COG0252	asparaginase activity
AXF14_RS05690	COG1113	amino acid transport
AXF14_RS05710	COG0704	Plays a role in the regulation of phosphate uptake
AXF14_RS05715	COG5002	protein histidine kinase activity
AXF14_RS05720	COG0745	RESPONSE REGULATOR receiver
AXF14_RS05735	COG1764	response to oxidative stress
AXF14_RS05745	COG0494	nUDIX hydrolase
AXF14_RS05755	COG1070	Carbohydrate kinase
AXF14_RS05765	COG0803	Belongs to the bacterial solute-binding protein 9 family
AXF14_RS05775	COG1121	(ABC) transporter
AXF14_RS05780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXF14_RS05785	COG0393	Putative heavy-metal-binding
AXF14_RS05800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXF14_RS05810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXF14_RS05815	COG1643	Atp-dependent helicase
AXF14_RS05840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXF14_RS05845	COG3142	Participates in the control of copper homeostasis
AXF14_RS05855	COG1132	(ABC) transporter
AXF14_RS05860	COG1132	(ABC) transporter
AXF14_RS05865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AXF14_RS05870	COG2860	membrane
AXF14_RS05950	COG2003	Belongs to the UPF0758 family
AXF14_RS05955	COG0714	Associated with various cellular activities
AXF14_RS06035	COG0717	Belongs to the dCTP deaminase family
AXF14_RS06045	COG2176	DNA-directed DNA polymerase activity
AXF14_RS06050	COG0778	Nitroreductase
AXF14_RS06070	COG4221	oxidoreductase activity
AXF14_RS06075	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AXF14_RS06085	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AXF14_RS06100	COG0785	Cytochrome C biogenesis protein
AXF14_RS06105	COG1333	cytochrome c biogenesis protein
AXF14_RS06110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AXF14_RS06120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXF14_RS06135	COG0191	fructose-bisphosphate aldolase activity
AXF14_RS06165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXF14_RS06170	COG0672	)-iron permease
AXF14_RS06180	COG2837	iron assimilation
AXF14_RS06195	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AXF14_RS06215	COG0151	Belongs to the GarS family
AXF14_RS06220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXF14_RS06240	COG0047	phosphoribosylformylglycinamidine synthase activity
AXF14_RS06245	COG0438	transferase activity, transferring glycosyl groups
AXF14_RS06250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXF14_RS06260	COG0492	ferredoxin-NADP+ reductase activity
AXF14_RS06270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXF14_RS06275	COG4085	toxin activity
AXF14_RS06275	COG0737	Belongs to the 5'-nucleotidase family
AXF14_RS06275	COG1525	nuclease
AXF14_RS06300	COG0557	exoribonuclease II activity
AXF14_RS06305	COG2186	Transcriptional regulator
AXF14_RS06315	COG2084	Dehydrogenase
AXF14_RS06320	COG2610	gluconate transmembrane transporter activity
AXF14_RS06330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXF14_RS06385	COG1132	(ABC) transporter
AXF14_RS06390	COG1132	(ABC) transporter
AXF14_RS06400	COG1472	Belongs to the glycosyl hydrolase 3 family
AXF14_RS06430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXF14_RS06455	COG3265	gluconokinase activity
AXF14_RS06465	COG0513	Belongs to the DEAD box helicase family
AXF14_RS06470	COG3328	transposase activity
AXF14_RS06495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AXF14_RS06520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXF14_RS06545	COG0745	RESPONSE REGULATOR receiver
AXF14_RS06560	COG3485	protocatechuate 3,4-dioxygenase
AXF14_RS06565	COG0354	folic acid binding
AXF14_RS06575	COG1490	D-aminoacyl-tRNA deacylase activity
AXF14_RS06595	COG2197	response regulator
AXF14_RS06630	COG0604	alcohol dehydrogenase
AXF14_RS06635	COG1846	Transcriptional regulator
AXF14_RS06645	COG0477	Major facilitator Superfamily
AXF14_RS06655	COG2197	response regulator
AXF14_RS06670	COG2211	Major facilitator Superfamily
AXF14_RS06680	COG0477	Major facilitator Superfamily
AXF14_RS06685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXF14_RS06685	COG0574	Belongs to the PEP-utilizing enzyme family
AXF14_RS06690	COG0714	Associated with various cellular activities
AXF14_RS06705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AXF14_RS06710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AXF14_RS06715	COG2267	carboxylic ester hydrolase activity
AXF14_RS06720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXF14_RS06725	COG2873	o-acetylhomoserine
AXF14_RS06735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AXF14_RS06740	COG2027	D-alanyl-D-alanine carboxypeptidase
AXF14_RS06750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AXF14_RS06755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXF14_RS06760	COG0302	gtp cyclohydrolase
AXF14_RS06765	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AXF14_RS06770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXF14_RS06800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXF14_RS06805	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXF14_RS06820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXF14_RS06825	COG3321	synthase
AXF14_RS06825	COG0604	alcohol dehydrogenase
AXF14_RS06860	COG2814	Major facilitator Superfamily
AXF14_RS06870	COG1556	Lactate utilization protein
AXF14_RS06875	COG1139	Iron-sulfur cluster binding protein
AXF14_RS06880	COG0247	lactate metabolic process
AXF14_RS06885	COG1620	l-lactate permease
AXF14_RS06890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXF14_RS06895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AXF14_RS06900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXF14_RS06910	COG0247	lactate metabolic process
AXF14_RS06915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXF14_RS06925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AXF14_RS06940	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AXF14_RS06950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AXF14_RS06955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXF14_RS06965	COG2814	Major facilitator Superfamily
AXF14_RS06975	COG2390	Transcriptional regulator
AXF14_RS06985	COG2376	Dihydroxyacetone kinase
AXF14_RS06990	COG2376	Dihydroxyacetone kinase
AXF14_RS07005	COG3775	system Galactitol-specific IIC component
AXF14_RS07045	COG2017	converts alpha-aldose to the beta-anomer
AXF14_RS07060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXF14_RS07070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXF14_RS07080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AXF14_RS07090	COG1115	amino acid carrier protein
AXF14_RS07095	COG0436	Aminotransferase
AXF14_RS07110	COG0250	Participates in transcription elongation, termination and antitermination
AXF14_RS07115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXF14_RS07120	COG0081	regulation of translation
AXF14_RS07135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXF14_RS07140	COG0222	ribosome binding
AXF14_RS07145	COG0085	RNA polymerase activity
AXF14_RS07150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXF14_RS07155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXF14_RS07160	COG0049	tRNA binding
AXF14_RS07165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXF14_RS07170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXF14_RS07175	COG0051	transcription antitermination factor activity, RNA binding
AXF14_RS07180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXF14_RS07185	COG0088	Forms part of the polypeptide exit tunnel
AXF14_RS07190	COG0089	rRNA binding
AXF14_RS07195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXF14_RS07200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXF14_RS07205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXF14_RS07210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXF14_RS07215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXF14_RS07220	COG0255	Belongs to the universal ribosomal protein uL29 family
AXF14_RS07225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXF14_RS07230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXF14_RS07235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXF14_RS07240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXF14_RS07245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXF14_RS07255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXF14_RS07265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXF14_RS07270	COG1841	ribosomal large subunit assembly
AXF14_RS07275	COG0200	Binds to the 23S rRNA
AXF14_RS07285	COG0563	adenylate kinase activity
AXF14_RS07295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXF14_RS07300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXF14_RS07305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXF14_RS07310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXF14_RS07315	COG0202	RNA polymerase activity
AXF14_RS07320	COG0203	ribosomal protein L17
AXF14_RS07335	COG0101	tRNA pseudouridine synthase activity
AXF14_RS07340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXF14_RS07355	COG1072	(Pantothenic acid kinase))
AXF14_RS07360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXF14_RS07375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXF14_RS07380	COG0802	atpase or kinase
AXF14_RS07405	COG1053	succinate dehydrogenase
AXF14_RS07410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXF14_RS07415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXF14_RS07420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AXF14_RS07435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXF14_RS07455	COG0516	GMP reductase activity
AXF14_RS07460	COG1175	transmembrane transport
AXF14_RS07465	COG0395	ABC-type sugar transport system, permease component
AXF14_RS07475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXF14_RS07480	COG2095	MarC family integral membrane protein
AXF14_RS07490	COG4975	Glucose uptake
AXF14_RS07495	COG1733	regulation of RNA biosynthetic process
AXF14_RS07505	COG0328	RNA-DNA hybrid ribonuclease activity
AXF14_RS07510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXF14_RS07520	COG1609	Transcriptional regulator
AXF14_RS07525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXF14_RS07525	COG0519	Catalyzes the synthesis of GMP from XMP
AXF14_RS07570	COG2409	Drug exporters of the RND superfamily
AXF14_RS07580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AXF14_RS07585	COG3328	transposase activity
AXF14_RS07590	COG5650	phosphatidylinositol metabolic process
AXF14_RS07620	COG1136	(ABC) transporter
AXF14_RS07620	COG0577	efflux transmembrane transporter activity
AXF14_RS07630	COG0656	L-ascorbic acid biosynthetic process
AXF14_RS07655	COG2197	response regulator
AXF14_RS07670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXF14_RS07680	COG0356	it plays a direct role in the translocation of protons across the membrane
AXF14_RS07685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXF14_RS07690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXF14_RS07695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXF14_RS07700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXF14_RS07705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXF14_RS07710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXF14_RS07715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXF14_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
AXF14_RS07735	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AXF14_RS07745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AXF14_RS07750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXF14_RS07775	COG1136	(ABC) transporter
AXF14_RS07775	COG0577	efflux transmembrane transporter activity
AXF14_RS07780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXF14_RS07785	COG0254	rRNA binding
AXF14_RS07790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXF14_RS07795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXF14_RS07800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXF14_RS07810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXF14_RS07815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXF14_RS07830	COG1254	Belongs to the acylphosphatase family
AXF14_RS07835	COG1621	beta-fructofuranosidase activity
AXF14_RS07835	COG5492	domain, Protein
AXF14_RS07835	COG3583	domain protein
AXF14_RS07840	COG1621	beta-fructofuranosidase activity
AXF14_RS07860	COG1136	(ABC) transporter
AXF14_RS07860	COG0577	efflux transmembrane transporter activity
AXF14_RS07865	COG1136	(ABC) transporter
AXF14_RS07865	COG0577	efflux transmembrane transporter activity
AXF14_RS07875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXF14_RS07880	COG1609	Transcriptional regulator
AXF14_RS07890	COG2211	Major facilitator Superfamily
AXF14_RS07915	COG1744	ABC transporter substrate-binding protein PnrA-like
AXF14_RS07920	COG3845	ABC transporter
AXF14_RS07925	COG4603	Belongs to the binding-protein-dependent transport system permease family
AXF14_RS07930	COG1079	Belongs to the binding-protein-dependent transport system permease family
AXF14_RS07945	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXF14_RS07950	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AXF14_RS07980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXF14_RS08005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AXF14_RS08020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AXF14_RS08025	COG1611	Belongs to the LOG family
AXF14_RS08040	COG0489	protein tyrosine kinase activity
AXF14_RS08040	COG2151	metal-sulfur cluster biosynthetic enzyme
AXF14_RS08045	COG2755	lipolytic protein G-D-S-L family
AXF14_RS08045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AXF14_RS08055	COG2239	Acts as a magnesium transporter
AXF14_RS08065	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS08070	COG1082	Xylose isomerase domain protein TIM barrel
AXF14_RS08090	COG0006	proline dipeptidase activity
AXF14_RS08105	COG2095	MarC family integral membrane protein
AXF14_RS08150	COG3415	Transposase
AXF14_RS08150	COG2801	Transposase and inactivated derivatives
AXF14_RS08155	COG2801	Transposase and inactivated derivatives
AXF14_RS08155	COG3415	Transposase
AXF14_RS08160	COG0513	Belongs to the DEAD box helicase family
AXF14_RS08175	COG0473	3-isopropylmalate dehydrogenase activity
AXF14_RS08180	COG4948	Mandelate Racemase Muconate Lactonizing
AXF14_RS08270	COG0583	DNA-binding transcription factor activity
AXF14_RS08275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXF14_RS08290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXF14_RS08295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXF14_RS08305	COG2190	(PTS) system
AXF14_RS08310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXF14_RS08315	COG2188	Transcriptional regulator
AXF14_RS08320	COG1263	PTS System
AXF14_RS08335	COG3590	peptidase
AXF14_RS08360	COG1045	serine acetyltransferase
AXF14_RS08370	COG1739	Uncharacterized protein family UPF0029
AXF14_RS08395	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXF14_RS08410	COG0740	serine-type endopeptidase activity
AXF14_RS08415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXF14_RS08420	COG0287	Prephenate dehydrogenase
AXF14_RS08420	COG1605	Chorismate mutase
AXF14_RS08465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AXF14_RS08500	COG0366	Alpha amylase catalytic
AXF14_RS08505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXF14_RS08505	COG2190	(PTS) system
AXF14_RS08505	COG1263	PTS System
AXF14_RS08515	COG0730	response to heat
AXF14_RS08520	COG1648	precorrin-2 dehydrogenase activity
AXF14_RS08520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXF14_RS08540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXF14_RS08545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXF14_RS08565	COG0285	dihydrofolate synthase activity
AXF14_RS08580	COG1461	Dihydroxyacetone kinase
AXF14_RS08585	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AXF14_RS08590	COG0105	UTP biosynthetic process
AXF14_RS08600	COG4152	abc transporter atp-binding protein
AXF14_RS08605	COG1196	nuclear chromosome segregation
AXF14_RS08635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AXF14_RS08660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXF14_RS08670	COG1837	Belongs to the UPF0109 family
AXF14_RS08675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXF14_RS08680	COG0336	Belongs to the RNA methyltransferase TrmD family
AXF14_RS08685	COG0681	Belongs to the peptidase S26 family
AXF14_RS08695	COG0681	Belongs to the peptidase S26 family
AXF14_RS08700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXF14_RS08710	COG0792	nuclease activity
AXF14_RS08735	COG0052	Belongs to the universal ribosomal protein uS2 family
AXF14_RS08740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXF14_RS08755	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS08760	COG0233	cytoplasmic translational termination
AXF14_RS08770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXF14_RS08780	COG0750	zinc metalloprotease
AXF14_RS08790	COG0183	Belongs to the thiolase family
AXF14_RS08795	COG3425	synthase
AXF14_RS08835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXF14_RS08840	COG0442	prolyl-tRNA aminoacylation
AXF14_RS08850	COG0779	Required for maturation of 30S ribosomal subunits
AXF14_RS08855	COG0195	Participates in both transcription termination and antitermination
AXF14_RS08865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXF14_RS08885	COG0330	HflC and HflK could
AXF14_RS08890	COG2962	Rard protein
AXF14_RS08895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXF14_RS08900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXF14_RS08910	COG0196	riboflavin kinase activity
AXF14_RS08920	COG1185	polyribonucleotide nucleotidyltransferase activity
AXF14_RS08925	COG0612	Peptidase, M16
AXF14_RS08940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXF14_RS08950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXF14_RS08955	COG0318	PFAM AMP-dependent synthetase and ligase
AXF14_RS08960	COG0318	PFAM AMP-dependent synthetase and ligase
AXF14_RS08975	COG2271	Major facilitator Superfamily
AXF14_RS08985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXF14_RS08995	COG2001	Belongs to the MraZ family
AXF14_RS09000	COG0275	rRNA processing
AXF14_RS09015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AXF14_RS09020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXF14_RS09025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXF14_RS09030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXF14_RS09035	COG0772	Belongs to the SEDS family
AXF14_RS09045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXF14_RS09055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AXF14_RS09060	COG1496	oxidoreductase activity
AXF14_RS09065	COG1799	cell septum assembly
AXF14_RS09075	COG3599	regulation of cell shape
AXF14_RS09080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AXF14_RS09100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AXF14_RS09105	COG0587	DNA-directed DNA polymerase activity
AXF14_RS09110	COG3328	transposase activity
AXF14_RS09120	COG2501	S4 domain
AXF14_RS09155	COG3328	transposase activity
AXF14_RS09165	COG0732	type I restriction modification DNA specificity domain
AXF14_RS09205	COG4139	cobalamin transport
AXF14_RS09210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AXF14_RS09245	COG0598	Magnesium transport protein CorA
AXF14_RS09250	COG0514	ATP-dependent DNA helicase (RecQ)
AXF14_RS09285	COG1070	Carbohydrate kinase
AXF14_RS09295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXF14_RS09300	COG3775	system Galactitol-specific IIC component
AXF14_RS09305	COG0025	NhaP-type Na H and K H
AXF14_RS09320	COG0131	Imidazoleglycerol-phosphate dehydratase
AXF14_RS09330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXF14_RS09335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXF14_RS09345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXF14_RS09350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXF14_RS09355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXF14_RS09365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXF14_RS09370	COG1175	transmembrane transport
AXF14_RS09375	COG0395	ABC-type sugar transport system, permease component
AXF14_RS09380	COG1653	transport
AXF14_RS09395	COG1486	melibiose metabolic process
AXF14_RS09400	COG1126	abc transporter atp-binding protein
AXF14_RS09405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXF14_RS09410	COG0765	amino acid transport
AXF14_RS09415	COG0765	amino acid transport
AXF14_RS09420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXF14_RS09425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXF14_RS09425	COG0072	phenylalanine-tRNA ligase activity
AXF14_RS09430	COG0656	L-ascorbic acid biosynthetic process
AXF14_RS09440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXF14_RS09450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXF14_RS09455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXF14_RS09460	COG1438	arginine binding
AXF14_RS09465	COG0137	argininosuccinate synthase activity
AXF14_RS09470	COG0165	Argininosuccinate lyase
AXF14_RS09475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXF14_RS09485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXF14_RS09525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXF14_RS09530	COG0497	DNA recombination
AXF14_RS09560	COG0504	CTP synthase activity
AXF14_RS09570	COG1609	Transcriptional regulator
AXF14_RS09580	COG1175	transmembrane transport
AXF14_RS09585	COG0395	ABC-type sugar transport system, permease component
AXF14_RS09595	COG1609	Transcriptional regulator
AXF14_RS09605	COG0719	Fe-S assembly protein
AXF14_RS09615	COG0396	ATPase activity
AXF14_RS09625	COG0822	iron-sulfur transferase activity
AXF14_RS09630	COG2151	metal-sulfur cluster biosynthetic enzyme
AXF14_RS09650	COG3189	MarR family transcriptional regulator
AXF14_RS09660	COG0167	dihydroorotate dehydrogenase activity
AXF14_RS09675	COG0667	Aldo Keto reductase
AXF14_RS09685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AXF14_RS09695	COG1609	Transcriptional regulator
AXF14_RS09700	COG0366	Alpha amylase catalytic
AXF14_RS09705	COG3833	ABC-type maltose transport systems, permease component
AXF14_RS09710	COG1175	transmembrane transport
AXF14_RS09715	COG2182	Extracellular solute-binding protein
AXF14_RS09730	COG0358	DNA primase activity
AXF14_RS09765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXF14_RS09770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXF14_RS09780	COG1027	Aspartate ammonia-lyase
AXF14_RS09790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AXF14_RS09805	COG0384	phenazine biosynthesis protein PhzF
AXF14_RS09815	COG2197	response regulator
AXF14_RS09820	COG4585	Histidine kinase
AXF14_RS09825	COG1131	(ABC) transporter
AXF14_RS09845	COG2226	methyltransferase
AXF14_RS09845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXF14_RS09845	COG0596	Alpha beta hydrolase
AXF14_RS09855	COG5504	Zn-dependent protease
AXF14_RS09880	COG0436	Aminotransferase
AXF14_RS09895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXF14_RS09905	COG3022	response to hydroperoxide
AXF14_RS09925	COG0588	phosphoglycerate mutase activity
AXF14_RS09935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AXF14_RS09940	COG0174	glutamine synthetase
AXF14_RS09945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AXF14_RS09955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXF14_RS09965	COG0765	amino acid transport
AXF14_RS09970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXF14_RS09980	COG0174	glutamine synthetase
AXF14_RS09990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXF14_RS09995	COG0321	lipoyl(octanoyl) transferase activity
AXF14_RS10000	COG0515	serine threonine protein kinase
AXF14_RS10005	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXF14_RS10010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXF14_RS10015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AXF14_RS10025	COG0038	chloride channel
AXF14_RS10035	COG1882	Formate acetyltransferase
AXF14_RS10110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXF14_RS10120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXF14_RS10125	COG1560	Kdo2-lipid A biosynthetic process
AXF14_RS10130	COG0438	transferase activity, transferring glycosyl groups
AXF14_RS10145	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AXF14_RS10150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AXF14_RS10155	COG0494	nUDIX hydrolase
AXF14_RS10160	COG0217	transcriptional regulatory protein
AXF14_RS10165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXF14_RS10170	COG0632	four-way junction helicase activity
AXF14_RS10175	COG2255	four-way junction helicase activity
AXF14_RS10185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXF14_RS10190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXF14_RS10195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXF14_RS10200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXF14_RS10210	COG1196	nuclear chromosome segregation
AXF14_RS10215	COG1305	Transglutaminase-like
AXF14_RS10235	COG1305	Transglutaminase-like
AXF14_RS10240	COG0243	molybdopterin cofactor binding
AXF14_RS10240	COG3383	formate dehydrogenase (NAD+) activity
AXF14_RS10245	COG0437	4 iron, 4 sulfur cluster binding
AXF14_RS10260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AXF14_RS10265	COG0488	(ABC) transporter
AXF14_RS10290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXF14_RS10310	COG2826	transposase and inactivated derivatives, IS30 family
AXF14_RS10325	COG2801	Transposase and inactivated derivatives
AXF14_RS10330	COG2963	transposase activity
AXF14_RS10350	COG2826	transposase and inactivated derivatives, IS30 family
AXF14_RS10360	COG1116	anion transmembrane transporter activity
AXF14_RS10360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXF14_RS10385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXF14_RS10395	COG0009	L-threonylcarbamoyladenylate synthase
AXF14_RS10405	COG2409	Drug exporters of the RND superfamily
AXF14_RS10415	COG0730	response to heat
AXF14_RS10420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXF14_RS10425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXF14_RS10430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXF14_RS10440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXF14_RS10445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXF14_RS10450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXF14_RS10460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXF14_RS10465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXF14_RS10470	COG0702	epimerase
AXF14_RS10475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AXF14_RS10480	COG0540	Belongs to the ATCase OTCase family
AXF14_RS10485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXF14_RS10495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AXF14_RS10500	COG0284	orotidine-5'-phosphate decarboxylase activity
AXF14_RS10505	COG0194	GDP metabolic process
AXF14_RS10510	COG0194	GDP metabolic process
AXF14_RS10515	COG1758	RNA polymerase activity
AXF14_RS10525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AXF14_RS10530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXF14_RS10540	COG4716	Myosin-crossreactive antigen
AXF14_RS10550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXF14_RS10560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXF14_RS10570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXF14_RS10580	COG4770	biotin carboxylase activity
AXF14_RS10585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXF14_RS10590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXF14_RS10620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXF14_RS10625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXF14_RS10630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXF14_RS10635	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AXF14_RS10640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXF14_RS10645	COG0140	phosphoribosyl-ATP diphosphatase activity
AXF14_RS10655	COG1131	(ABC) transporter
AXF14_RS10660	COG2197	response regulator
AXF14_RS10665	COG4585	Histidine kinase
AXF14_RS10675	COG2378	regulation of single-species biofilm formation
AXF14_RS10685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXF14_RS10690	COG0805	protein transport
AXF14_RS10705	COG2354	Protein conserved in bacteria
AXF14_RS10715	COG1216	Glycosyl transferase, family 2
AXF14_RS10725	COG0205	6-phosphofructokinase activity
AXF14_RS10735	COG0604	alcohol dehydrogenase
AXF14_RS10745	COG0577	efflux transmembrane transporter activity
AXF14_RS10750	COG1136	(ABC) transporter
AXF14_RS10760	COG1609	Transcriptional regulator
AXF14_RS10765	COG2190	(PTS) system
AXF14_RS10765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXF14_RS10765	COG1263	PTS System
AXF14_RS10780	COG2814	Major facilitator Superfamily
AXF14_RS10790	COG0443	Heat shock 70 kDa protein
AXF14_RS10795	COG0667	Aldo Keto reductase
AXF14_RS10825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AXF14_RS10845	COG4989	oxidoreductase activity
AXF14_RS10860	COG0657	acetylesterase activity
AXF14_RS10880	COG2818	Glycosylase
AXF14_RS10885	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AXF14_RS10895	COG0662	Cupin 2, conserved barrel domain protein
AXF14_RS10900	COG1028	Short-chain dehydrogenase reductase Sdr
AXF14_RS10915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AXF14_RS10920	COG0166	Belongs to the GPI family
AXF14_RS10925	COG1160	GTP binding
AXF14_RS10940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AXF14_RS10960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXF14_RS10965	COG0149	triose-phosphate isomerase activity
AXF14_RS10975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AXF14_RS10980	COG1481	regulation of sporulation
AXF14_RS10990	COG1660	Displays ATPase and GTPase activities
AXF14_RS10995	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AXF14_RS11010	COG0322	excinuclease ABC activity
AXF14_RS11015	COG0561	phosphatase activity
AXF14_RS11065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXF14_RS11090	COG0556	nucleotide-excision repair
AXF14_RS11095	COG0237	dephospho-CoA kinase activity
AXF14_RS11100	COG2076	Multidrug Resistance protein
AXF14_RS11105	COG0710	3-dehydroquinate dehydratase activity
AXF14_RS11110	COG0738	Major facilitator superfamily
AXF14_RS11115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXF14_RS11130	COG0539	negative regulation of cytoplasmic translation
AXF14_RS11140	COG2050	protein possibly involved in aromatic compounds catabolism
AXF14_RS11165	COG0070	glutamate synthase
AXF14_RS11165	COG0069	glutamate synthase activity
AXF14_RS11165	COG0067	glutamate synthase
AXF14_RS11170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AXF14_RS11175	COG0134	indole-3-glycerol-phosphate synthase activity
AXF14_RS11180	COG1297	OPT oligopeptide transporter protein
AXF14_RS11190	COG0107	imidazoleglycerol-phosphate synthase activity
AXF14_RS11205	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AXF14_RS11215	COG4122	O-methyltransferase activity
AXF14_RS11220	COG1222	aaa ATPase
AXF14_RS11235	COG2264	protein methyltransferase activity
AXF14_RS11245	COG4115	mRNA cleavage
AXF14_RS11250	COG1121	(ABC) transporter
AXF14_RS11255	COG1121	(ABC) transporter
AXF14_RS11270	COG0488	(ABC) transporter
AXF14_RS11295	COG2814	Major facilitator Superfamily
AXF14_RS11300	COG0517	IMP dehydrogenase activity
AXF14_RS11300	COG1994	Peptidase M50
AXF14_RS11310	COG2391	methyltransferase activity
AXF14_RS11315	COG0425	Belongs to the sulfur carrier protein TusA family
AXF14_RS11320	COG0667	Aldo Keto reductase
AXF14_RS11340	COG0028	Belongs to the TPP enzyme family
AXF14_RS11350	COG0738	Major facilitator superfamily
AXF14_RS11365	COG0676	glucose-6-phosphate 1-epimerase activity
AXF14_RS11380	COG0587	DNA-directed DNA polymerase activity
AXF14_RS11385	COG0833	amino acid
AXF14_RS11400	COG1435	thymidine kinase activity
AXF14_RS11420	COG1881	PFAM PEBP family protein
AXF14_RS11430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXF14_RS11435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXF14_RS11445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXF14_RS11455	COG0531	amino acid
AXF14_RS11460	COG0569	domain protein
AXF14_RS11505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXF14_RS11510	COG1929	Belongs to the glycerate kinase type-1 family
AXF14_RS11520	COG0187	DNA topoisomerase II activity
AXF14_RS11535	COG0351	phosphomethylpyrimidine kinase
AXF14_RS11540	COG0352	thiamine-phosphate diphosphorylase activity
AXF14_RS11545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AXF14_RS11550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXF14_RS11555	COG0142	geranyltranstransferase activity
AXF14_RS11560	COG0515	serine threonine protein kinase
AXF14_RS11560	COG2815	serine threonine protein kinase
AXF14_RS11565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AXF14_RS11570	COG0205	6-phosphofructokinase activity
AXF14_RS11605	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS11610	COG0488	(ABC) transporter
AXF14_RS11650	COG1119	ATPase activity
AXF14_RS11660	COG0297	glycogen (starch) synthase activity
AXF14_RS11670	COG0560	Phosphoserine phosphatase
AXF14_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
AXF14_RS11700	COG0423	glycine-tRNA ligase activity
AXF14_RS11715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXF14_RS11730	COG0549	Belongs to the carbamate kinase family
AXF14_RS11735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXF14_RS11740	COG1381	Involved in DNA repair and RecF pathway recombination
AXF14_RS11745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXF14_RS11760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXF14_RS11770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXF14_RS11780	COG3876	Protein conserved in bacteria
AXF14_RS11795	COG0484	heat shock protein binding
AXF14_RS11800	COG1420	regulation of RNA biosynthetic process
AXF14_RS11845	COG2197	response regulator
AXF14_RS11860	COG3845	ABC transporter
AXF14_RS11890	COG2271	Major facilitator Superfamily
AXF14_RS11915	COG3328	transposase activity
AXF14_RS11930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AXF14_RS11940	COG0481	GTPase activity
AXF14_RS11960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXF14_RS11965	COG0512	Glutamine amidotransferase of anthranilate synthase
AXF14_RS11970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXF14_RS11980	COG0159	tryptophan synthase activity
AXF14_RS11995	COG1136	(ABC) transporter
AXF14_RS12000	COG0268	Binds directly to 16S ribosomal RNA
AXF14_RS12015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXF14_RS12015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXF14_RS12020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXF14_RS12035	COG1555	photosystem II stabilization
AXF14_RS12040	COG1307	EDD domain protein, DegV family
AXF14_RS12045	COG0433	COG0433 Predicted ATPase
AXF14_RS12065	COG0495	leucyl-tRNA aminoacylation
AXF14_RS12070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXF14_RS12075	COG0537	adenosine 5'-monophosphoramidase activity
AXF14_RS12095	COG0733	neurotransmitter:sodium symporter activity
AXF14_RS12100	COG0813	purine-nucleoside phosphorylase activity
AXF14_RS12115	COG3415	Transposase
AXF14_RS12115	COG2801	Transposase and inactivated derivatives
AXF14_RS12125	COG1940	carbohydrate kinase activity
AXF14_RS12135	COG3328	transposase activity
AXF14_RS12145	COG2801	Transposase and inactivated derivatives
AXF14_RS12165	COG2826	transposase and inactivated derivatives, IS30 family
AXF14_RS12170	COG2801	Transposase and inactivated derivatives
AXF14_RS12185	COG0415	Belongs to the DNA photolyase family
AXF14_RS12220	COG0640	Transcriptional regulator
AXF14_RS12225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXF14_RS12235	COG2814	Major facilitator Superfamily
AXF14_RS12260	COG0406	alpha-ribazole phosphatase activity
AXF14_RS12265	COG0799	negative regulation of ribosome biogenesis
AXF14_RS12275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXF14_RS12305	COG1132	(ABC) transporter
AXF14_RS12340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AXF14_RS12355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXF14_RS12360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXF14_RS12365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXF14_RS12370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AXF14_RS12375	COG1530	ribonuclease E activity
AXF14_RS12380	COG1271	oxidase subunit
AXF14_RS12385	COG1294	oxidase, subunit
AXF14_RS12390	COG4988	ABC transporter
AXF14_RS12395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AXF14_RS12410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXF14_RS12415	COG0571	ribonuclease III activity
AXF14_RS12440	COG0738	Major facilitator superfamily
AXF14_RS12445	COG4154	Belongs to the RbsD FucU family
AXF14_RS12450	COG1070	Carbohydrate kinase
AXF14_RS12460	COG0235	Class ii aldolase
AXF14_RS12475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXF14_RS12480	COG1461	Dihydroxyacetone kinase
AXF14_RS12485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXF14_RS12500	COG2814	Major facilitator Superfamily
AXF14_RS12515	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXF14_RS12525	COG3547	Transposase (IS116 IS110 IS902 family)
AXF14_RS12530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXF14_RS12540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXF14_RS12545	COG0066	3-isopropylmalate dehydratase activity
AXF14_RS12565	COG0438	transferase activity, transferring glycosyl groups
AXF14_RS12570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXF14_RS12580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXF14_RS12590	COG1472	Belongs to the glycosyl hydrolase 3 family
AXF14_RS12600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXF14_RS12610	COG2813	Specifically methylates the guanine in position
AXF14_RS12620	COG1114	Component of the transport system for branched-chain amino acids
AXF14_RS12625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXF14_RS12630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXF14_RS12645	COG0523	cobalamin synthesis protein
AXF14_RS12650	COG2197	response regulator
AXF14_RS12660	COG0577	efflux transmembrane transporter activity
AXF14_RS12660	COG1136	(ABC) transporter
AXF14_RS12685	COG0596	Alpha beta hydrolase
AXF14_RS12690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXF14_RS12705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXF14_RS12705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXF14_RS12710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AXF14_RS12715	COG0509	glycine decarboxylation via glycine cleavage system
AXF14_RS12725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXF14_RS12730	COG1252	NADH dehydrogenase
AXF14_RS12735	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AXF14_RS12740	COG2137	regulation of response to DNA damage stimulus
AXF14_RS12745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXF14_RS12755	COG1396	sequence-specific DNA binding
AXF14_RS12760	COG1546	Belongs to the CinA family
AXF14_RS12760	COG1058	Belongs to the CinA family
AXF14_RS12770	COG3415	Transposase
AXF14_RS12770	COG2801	Transposase and inactivated derivatives
AXF14_RS12780	COG1674	ftsk spoiiie
AXF14_RS12790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AXF14_RS12815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXF14_RS12825	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXF14_RS12830	COG1115	amino acid carrier protein
AXF14_RS12835	COG1115	amino acid carrier protein
AXF14_RS12840	COG1115	amino acid carrier protein
AXF14_RS12845	COG1115	amino acid carrier protein
AXF14_RS12865	COG2040	homocysteine
AXF14_RS12870	COG0833	amino acid
AXF14_RS12875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AXF14_RS12885	COG3304	Inner membrane component domain
AXF14_RS12925	COG2801	Transposase and inactivated derivatives
AXF14_RS12925	COG3415	Transposase