locus-tag	class	description
CWS50_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWS50_RS00010	COG0592	DNA-directed DNA polymerase activity
CWS50_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWS50_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CWS50_RS00025	COG0187	DNA topoisomerase II activity
CWS50_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWS50_RS00055	COG0656	L-ascorbic acid biosynthetic process
CWS50_RS00080	COG3764	Sortase (surface protein transpeptidase)
CWS50_RS00085	COG0515	serine threonine protein kinase
CWS50_RS00090	COG0515	serine threonine protein kinase
CWS50_RS00095	COG0768	penicillin binding
CWS50_RS00110	COG1716	ATPase activity
CWS50_RS00115	COG1131	(ABC) transporter
CWS50_RS00115	COG0842	Transport permease protein
CWS50_RS00115	COG1716	ATPase activity
CWS50_RS00130	COG1966	Carbon starvation protein
CWS50_RS00150	COG2197	response regulator
CWS50_RS00155	COG1131	(ABC) transporter
CWS50_RS00165	COG1854	S-ribosylhomocysteine lyase activity
CWS50_RS00170	COG0471	metal ion transport
CWS50_RS00175	COG3852	Histidine kinase
CWS50_RS00185	COG0628	permease
CWS50_RS00200	COG2197	response regulator
CWS50_RS00230	COG1120	ATPase activity
CWS50_RS00235	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWS50_RS00240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWS50_RS00250	COG1940	carbohydrate kinase activity
CWS50_RS00260	COG1113	amino acid transport
CWS50_RS00310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWS50_RS00315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWS50_RS00335	COG2197	response regulator
CWS50_RS00450	COG1937	Protein conserved in bacteria
CWS50_RS00460	COG2197	response regulator
CWS50_RS00470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWS50_RS00510	COG1950	PFAM Membrane protein of
CWS50_RS00515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWS50_RS00565	COG1733	regulation of RNA biosynthetic process
CWS50_RS00580	COG2211	Major facilitator Superfamily
CWS50_RS00590	COG1609	Transcriptional regulator
CWS50_RS00605	COG0110	maltose O-acetyltransferase activity
CWS50_RS00675	COG1335	isochorismatase
CWS50_RS00685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWS50_RS00695	COG1653	transport
CWS50_RS00725	COG1674	ftsk spoiiie
CWS50_RS00815	COG0626	cystathionine gamma-synthase activity
CWS50_RS00820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWS50_RS00850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWS50_RS00865	COG1131	(ABC) transporter
CWS50_RS00880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWS50_RS00895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWS50_RS00900	COG0076	glutamate decarboxylase activity
CWS50_RS00905	COG0531	amino acid
CWS50_RS00915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWS50_RS00920	COG0113	porphobilinogen synthase activity
CWS50_RS00930	COG0181	hydroxymethylbilane synthase activity
CWS50_RS00940	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWS50_RS00945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWS50_RS00950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CWS50_RS00955	COG3253	May function as heme-dependent peroxidase
CWS50_RS00955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CWS50_RS00965	COG1309	transcriptional regulator
CWS50_RS00980	COG0366	Alpha amylase catalytic
CWS50_RS01040	COG1597	lipid kinase activity
CWS50_RS01070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CWS50_RS01075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWS50_RS01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWS50_RS01085	COG0431	NADPH-dependent FMN reductase
CWS50_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS01100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWS50_RS01125	COG0596	Alpha beta hydrolase
CWS50_RS01150	COG3177	Filamentation induced by cAMP protein fic
CWS50_RS01160	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWS50_RS01170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWS50_RS01185	COG4214	carbohydrate transport
CWS50_RS01200	COG2181	nitrate reductase activity
CWS50_RS01200	COG0247	lactate metabolic process
CWS50_RS01220	COG1674	ftsk spoiiie
CWS50_RS01335	COG3842	ATPase activity
CWS50_RS01400	COG1643	Atp-dependent helicase
CWS50_RS01410	COG3711	transcriptional antiterminator
CWS50_RS01410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWS50_RS01490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWS50_RS01535	COG0714	Associated with various cellular activities
CWS50_RS01605	COG2176	DNA-directed DNA polymerase activity
CWS50_RS01620	COG1063	alcohol dehydrogenase
CWS50_RS01645	COG0300	oxidoreductase activity
CWS50_RS01655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CWS50_RS01675	COG0191	fructose-bisphosphate aldolase activity
CWS50_RS01680	COG3409	Peptidoglycan-binding domain 1 protein
CWS50_RS01695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWS50_RS01735	COG1857	crispr-associated protein
CWS50_RS01750	COG1518	maintenance of DNA repeat elements
CWS50_RS01755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWS50_RS01780	COG1131	(ABC) transporter
CWS50_RS01785	COG4585	Histidine kinase
CWS50_RS01790	COG2197	response regulator
CWS50_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS01825	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
CWS50_RS01845	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CWS50_RS01855	COG0151	Belongs to the GarS family
CWS50_RS01860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWS50_RS01880	COG0047	phosphoribosylformylglycinamidine synthase activity
CWS50_RS01890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWS50_RS01900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWS50_RS01905	COG1349	DNA-binding transcription factor activity
CWS50_RS01915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWS50_RS01915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWS50_RS01915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWS50_RS01925	COG2084	Dehydrogenase
CWS50_RS01930	COG2610	gluconate transmembrane transporter activity
CWS50_RS01945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWS50_RS01985	COG3321	synthase
CWS50_RS01985	COG0300	oxidoreductase activity
CWS50_RS01985	COG0318	PFAM AMP-dependent synthetase and ligase
CWS50_RS01985	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWS50_RS01995	COG1830	Aldolase
CWS50_RS02000	COG2070	2-Nitropropane dioxygenase
CWS50_RS02000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWS50_RS02010	COG2368	4-hydroxyphenylacetate
CWS50_RS02015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWS50_RS02015	COG3321	synthase
CWS50_RS02015	COG4221	oxidoreductase activity
CWS50_RS02015	COG0300	oxidoreductase activity
CWS50_RS02050	COG1217	gtp-binding protein TYPA
CWS50_RS02085	COG2171	N-acyltransferase activity
CWS50_RS02090	COG0406	alpha-ribazole phosphatase activity
CWS50_RS02140	COG1116	anion transmembrane transporter activity
CWS50_RS02140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWS50_RS02145	COG3477	response to acidic pH
CWS50_RS02155	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWS50_RS02185	COG4948	Mandelate Racemase Muconate Lactonizing
CWS50_RS02190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CWS50_RS02200	COG2226	methyltransferase
CWS50_RS02205	COG0644	oxidoreductase
CWS50_RS02215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWS50_RS02220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWS50_RS02225	COG0649	NAD binding
CWS50_RS02235	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CWS50_RS02240	COG1034	ATP synthesis coupled electron transport
CWS50_RS02245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CWS50_RS02250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWS50_RS02260	COG0713	ATP synthesis coupled electron transport
CWS50_RS02265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWS50_RS02280	COG0142	geranyltranstransferase activity
CWS50_RS02290	COG0686	Belongs to the AlaDH PNT family
CWS50_RS02310	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CWS50_RS02315	COG0501	Belongs to the peptidase M48B family
CWS50_RS02330	COG1666	GTP binding
CWS50_RS02350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWS50_RS02365	COG0424	maF-like protein
CWS50_RS02380	COG0745	RESPONSE REGULATOR receiver
CWS50_RS02385	COG5002	protein histidine kinase activity
CWS50_RS02405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWS50_RS02415	COG1316	TRANSCRIPTIONal
CWS50_RS02420	COG1316	TRANSCRIPTIONal
CWS50_RS02435	COG0463	Glycosyl transferase, family 2
CWS50_RS02440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWS50_RS02485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CWS50_RS02490	COG1132	(ABC) transporter
CWS50_RS02545	COG0463	Glycosyl transferase, family 2
CWS50_RS02605	COG1482	cell wall glycoprotein biosynthetic process
CWS50_RS02650	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CWS50_RS02655	COG0714	Associated with various cellular activities
CWS50_RS02675	COG0745	RESPONSE REGULATOR receiver
CWS50_RS02680	COG5000	phosphorelay sensor kinase activity
CWS50_RS02680	COG5002	protein histidine kinase activity
CWS50_RS02690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWS50_RS02695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWS50_RS02700	COG0653	protein targeting
CWS50_RS02715	COG0516	GMP reductase activity
CWS50_RS02720	COG1929	Belongs to the glycerate kinase type-1 family
CWS50_RS02725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWS50_RS02740	COG0328	RNA-DNA hybrid ribonuclease activity
CWS50_RS02745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWS50_RS02780	COG1082	Xylose isomerase domain protein TIM barrel
CWS50_RS02795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWS50_RS02800	COG1609	Transcriptional regulator
CWS50_RS02805	COG2197	response regulator
CWS50_RS02825	COG1082	Xylose isomerase domain protein TIM barrel
CWS50_RS02830	COG0673	inositol 2-dehydrogenase activity
CWS50_RS02840	COG0673	inositol 2-dehydrogenase activity
CWS50_RS02845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWS50_RS02850	COG2188	Transcriptional regulator
CWS50_RS02865	COG3718	enzyme involved in inositol metabolism
CWS50_RS02935	COG0673	inositol 2-dehydrogenase activity
CWS50_RS02940	COG1082	Xylose isomerase domain protein TIM barrel
CWS50_RS02950	COG1733	regulation of RNA biosynthetic process
CWS50_RS02955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CWS50_RS02960	COG1063	alcohol dehydrogenase
CWS50_RS02970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWS50_RS02970	COG0519	Catalyzes the synthesis of GMP from XMP
CWS50_RS02990	COG2267	carboxylic ester hydrolase activity
CWS50_RS03020	COG0047	phosphoribosylformylglycinamidine synthase activity
CWS50_RS03040	COG2197	response regulator
CWS50_RS03050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWS50_RS03060	COG0356	it plays a direct role in the translocation of protons across the membrane
CWS50_RS03070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWS50_RS03075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWS50_RS03080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWS50_RS03085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWS50_RS03090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWS50_RS03095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWS50_RS03110	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CWS50_RS03120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWS50_RS03125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CWS50_RS03155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWS50_RS03160	COG0254	rRNA binding
CWS50_RS03165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWS50_RS03170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWS50_RS03175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWS50_RS03185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWS50_RS03190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWS50_RS03200	COG2197	response regulator
CWS50_RS03235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CWS50_RS03250	COG0662	Cupin 2, conserved barrel domain protein
CWS50_RS03250	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CWS50_RS03255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CWS50_RS03260	COG3281	Trehalose synthase
CWS50_RS03270	COG0366	Alpha amylase catalytic
CWS50_RS03295	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWS50_RS03300	COG1725	Transcriptional regulator
CWS50_RS03305	COG1131	(ABC) transporter
CWS50_RS03315	COG0482	sulfurtransferase activity
CWS50_RS03340	COG3480	Lon protease (S16) C-terminal proteolytic domain
CWS50_RS03355	COG1615	UPF0182 protein
CWS50_RS03425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CWS50_RS03440	COG0114	fumarate hydratase activity
CWS50_RS03445	COG0778	Nitroreductase
CWS50_RS03450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWS50_RS03450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWS50_RS03465	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CWS50_RS03485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWS50_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS03490	COG3321	synthase
CWS50_RS03490	COG0604	alcohol dehydrogenase
CWS50_RS03495	COG1695	Transcriptional regulator
CWS50_RS03505	COG1174	glycine betaine transport
CWS50_RS03520	COG2814	Major facilitator Superfamily
CWS50_RS03530	COG0673	inositol 2-dehydrogenase activity
CWS50_RS03545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWS50_RS03575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWS50_RS03585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWS50_RS03590	COG0154	amidase activity
CWS50_RS03595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWS50_RS03620	COG2985	domain, Protein
CWS50_RS03620	COG0569	domain protein
CWS50_RS03630	COG0440	acetolactate synthase activity
CWS50_RS03635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWS50_RS03640	COG0473	3-isopropylmalate dehydrogenase activity
CWS50_RS03645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWS50_RS03655	COG0438	transferase activity, transferring glycosyl groups
CWS50_RS03665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWS50_RS03680	COG1086	Polysaccharide biosynthesis protein
CWS50_RS03685	COG0438	transferase activity, transferring glycosyl groups
CWS50_RS03700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWS50_RS03715	COG0515	serine threonine protein kinase
CWS50_RS03750	COG2884	Cell division ATP-binding protein ftsE
CWS50_RS03755	COG2177	Part of the ABC transporter FtsEX involved in
CWS50_RS03760	COG0739	heme binding
CWS50_RS03795	COG0363	glucosamine-6-phosphate deaminase activity
CWS50_RS03815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CWS50_RS03825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWS50_RS03840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWS50_RS03845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CWS50_RS03895	COG3304	Inner membrane component domain
CWS50_RS03900	COG0833	amino acid
CWS50_RS03905	COG2040	homocysteine
CWS50_RS03920	COG1115	amino acid carrier protein
CWS50_RS03925	COG1115	amino acid carrier protein
CWS50_RS03930	COG1115	amino acid carrier protein
CWS50_RS03935	COG1115	amino acid carrier protein
CWS50_RS03940	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWS50_RS03950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWS50_RS03980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CWS50_RS03980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWS50_RS03985	COG1674	ftsk spoiiie
CWS50_RS03995	COG1058	Belongs to the CinA family
CWS50_RS03995	COG1546	Belongs to the CinA family
CWS50_RS04000	COG1396	sequence-specific DNA binding
CWS50_RS04010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CWS50_RS04015	COG2137	regulation of response to DNA damage stimulus
CWS50_RS04020	COG1653	transport
CWS50_RS04025	COG0395	ABC-type sugar transport system, permease component
CWS50_RS04040	COG1940	carbohydrate kinase activity
CWS50_RS04040	COG1846	Transcriptional regulator
CWS50_RS04045	COG1252	NADH dehydrogenase
CWS50_RS04055	COG0077	Prephenate dehydratase
CWS50_RS04060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWS50_RS04090	COG1136	(ABC) transporter
CWS50_RS04095	COG1132	(ABC) transporter
CWS50_RS04110	COG1116	anion transmembrane transporter activity
CWS50_RS04125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWS50_RS04130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWS50_RS04140	COG0672	)-iron permease
CWS50_RS04145	COG3470	protein probably involved in high-affinity Fe2 transport
CWS50_RS04160	COG0577	efflux transmembrane transporter activity
CWS50_RS04185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWS50_RS04190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWS50_RS04195	COG1764	response to oxidative stress
CWS50_RS04200	COG3321	synthase
CWS50_RS04200	COG0604	alcohol dehydrogenase
CWS50_RS04215	COG1201	RNA secondary structure unwinding
CWS50_RS04240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWS50_RS04255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWS50_RS04265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWS50_RS04280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWS50_RS04285	COG0066	3-isopropylmalate dehydratase activity
CWS50_RS04290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWS50_RS04300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWS50_RS04310	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWS50_RS04320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWS50_RS04325	COG1461	Dihydroxyacetone kinase
CWS50_RS04335	COG0742	ribosomal rna small subunit methyltransferase
CWS50_RS04340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWS50_RS04355	COG0571	ribonuclease III activity
CWS50_RS04360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CWS50_RS04375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CWS50_RS04380	COG4988	ABC transporter
CWS50_RS04385	COG1294	oxidase, subunit
CWS50_RS04390	COG1271	oxidase subunit
CWS50_RS04400	COG2814	Major facilitator Superfamily
CWS50_RS04430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWS50_RS04435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWS50_RS04440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWS50_RS04445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CWS50_RS04455	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWS50_RS04460	COG1129	ABC transporter
CWS50_RS04465	COG1609	Transcriptional regulator
CWS50_RS04475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWS50_RS04510	COG0745	RESPONSE REGULATOR receiver
CWS50_RS04515	COG5002	protein histidine kinase activity
CWS50_RS04535	COG1132	(ABC) transporter
CWS50_RS04545	COG0438	transferase activity, transferring glycosyl groups
CWS50_RS04555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWS50_RS04565	COG0799	negative regulation of ribosome biogenesis
CWS50_RS04595	COG1131	(ABC) transporter
CWS50_RS04605	COG1132	(ABC) transporter
CWS50_RS04615	COG0813	purine-nucleoside phosphorylase activity
CWS50_RS04620	COG0733	neurotransmitter:sodium symporter activity
CWS50_RS04650	COG0537	adenosine 5'-monophosphoramidase activity
CWS50_RS04655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWS50_RS04660	COG0495	leucyl-tRNA aminoacylation
CWS50_RS04665	COG0433	COG0433 Predicted ATPase
CWS50_RS04670	COG1307	EDD domain protein, DegV family
CWS50_RS04675	COG1596	polysaccharide export
CWS50_RS04675	COG1555	photosystem II stabilization
CWS50_RS04690	COG4868	Belongs to the UPF0371 family
CWS50_RS04695	COG0268	Binds directly to 16S ribosomal RNA
CWS50_RS04700	COG2814	Major facilitator Superfamily
CWS50_RS04710	COG0159	tryptophan synthase activity
CWS50_RS04725	COG0512	Glutamine amidotransferase of anthranilate synthase
CWS50_RS04730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWS50_RS04745	COG2197	response regulator
CWS50_RS04750	COG4152	abc transporter atp-binding protein
CWS50_RS04755	COG1668	transmembrane transport
CWS50_RS04765	COG2226	methyltransferase
CWS50_RS04835	COG1472	Belongs to the glycosyl hydrolase 3 family
CWS50_RS04845	COG1215	transferase activity, transferring glycosyl groups
CWS50_RS04880	COG0481	GTPase activity
CWS50_RS04885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWS50_RS04910	COG3775	system Galactitol-specific IIC component
CWS50_RS04920	COG2376	Dihydroxyacetone kinase
CWS50_RS04925	COG2376	Dihydroxyacetone kinase
CWS50_RS04930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWS50_RS04950	COG2390	Transcriptional regulator
CWS50_RS04970	COG1420	regulation of RNA biosynthetic process
CWS50_RS04975	COG0484	heat shock protein binding
CWS50_RS04985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWS50_RS05005	COG2226	methyltransferase
CWS50_RS05015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWS50_RS05025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWS50_RS05050	COG2184	nucleotidyltransferase activity
CWS50_RS05075	COG2184	nucleotidyltransferase activity
CWS50_RS05110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWS50_RS05115	COG1381	Involved in DNA repair and RecF pathway recombination
CWS50_RS05120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWS50_RS05130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWS50_RS05135	COG1121	(ABC) transporter
CWS50_RS05145	COG0423	glycine-tRNA ligase activity
CWS50_RS05170	COG3830	Belongs to the UPF0237 family
CWS50_RS05170	COG0560	Phosphoserine phosphatase
CWS50_RS05180	COG0297	glycogen (starch) synthase activity
CWS50_RS05190	COG1119	ATPase activity
CWS50_RS05220	COG0488	(ABC) transporter
CWS50_RS05255	COG0205	6-phosphofructokinase activity
CWS50_RS05260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CWS50_RS05265	COG0515	serine threonine protein kinase
CWS50_RS05265	COG2815	serine threonine protein kinase
CWS50_RS05270	COG0142	geranyltranstransferase activity
CWS50_RS05275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWS50_RS05310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWS50_RS05355	COG0569	domain protein
CWS50_RS05365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWS50_RS05370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWS50_RS05390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWS50_RS05395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CWS50_RS05405	COG3547	Transposase (IS116 IS110 IS902 family)
CWS50_RS05410	COG4221	oxidoreductase activity
CWS50_RS05415	COG1881	PFAM PEBP family protein
CWS50_RS05425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWS50_RS05430	COG1435	thymidine kinase activity
CWS50_RS05465	COG0477	Major facilitator Superfamily
CWS50_RS05475	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWS50_RS05485	COG0667	Aldo Keto reductase
CWS50_RS05490	COG0425	Belongs to the sulfur carrier protein TusA family
CWS50_RS05495	COG2391	methyltransferase activity
CWS50_RS05505	COG0517	IMP dehydrogenase activity
CWS50_RS05505	COG1994	Peptidase M50
CWS50_RS05520	COG1222	aaa ATPase
CWS50_RS05525	COG4122	O-methyltransferase activity
CWS50_RS05535	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CWS50_RS05545	COG0107	imidazoleglycerol-phosphate synthase activity
CWS50_RS05565	COG0134	indole-3-glycerol-phosphate synthase activity
CWS50_RS05570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWS50_RS05590	COG1120	ATPase activity
CWS50_RS05595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWS50_RS05610	COG1834	amidinotransferase
CWS50_RS05640	COG2050	protein possibly involved in aromatic compounds catabolism
CWS50_RS05650	COG0539	negative regulation of cytoplasmic translation
CWS50_RS05655	COG0237	dephospho-CoA kinase activity
CWS50_RS05660	COG0556	nucleotide-excision repair
CWS50_RS05700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWS50_RS05705	COG1518	maintenance of DNA repeat elements
CWS50_RS05785	COG0583	DNA-binding transcription factor activity
CWS50_RS05790	COG0322	excinuclease ABC activity
CWS50_RS05795	COG3711	transcriptional antiterminator
CWS50_RS05800	COG2190	(PTS) system
CWS50_RS05800	COG1263	PTS System
CWS50_RS05800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWS50_RS05810	COG1660	Displays ATPase and GTPase activities
CWS50_RS05820	COG1481	regulation of sporulation
CWS50_RS05825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWS50_RS05830	COG0126	phosphoglycerate kinase activity
CWS50_RS05835	COG0149	triose-phosphate isomerase activity
CWS50_RS05840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWS50_RS05855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CWS50_RS05860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWS50_RS05875	COG1160	GTP binding
CWS50_RS05900	COG0166	Belongs to the GPI family
CWS50_RS05905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWS50_RS05920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CWS50_RS05950	COG0363	glucosamine-6-phosphate deaminase activity
CWS50_RS05965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CWS50_RS05985	COG0667	Aldo Keto reductase
CWS50_RS05990	COG0443	Heat shock 70 kDa protein
CWS50_RS06005	COG1621	beta-fructofuranosidase activity
CWS50_RS06010	COG2190	(PTS) system
CWS50_RS06010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWS50_RS06010	COG1263	PTS System
CWS50_RS06015	COG1609	Transcriptional regulator
CWS50_RS06020	COG1136	(ABC) transporter
CWS50_RS06040	COG0205	6-phosphofructokinase activity
CWS50_RS06050	COG1216	Glycosyl transferase, family 2
CWS50_RS06065	COG0805	protein transport
CWS50_RS06070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWS50_RS06075	COG2378	regulation of single-species biofilm formation
CWS50_RS06095	COG0140	phosphoribosyl-ATP diphosphatase activity
CWS50_RS06100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWS50_RS06105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWS50_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWS50_RS06115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWS50_RS06120	COG2814	Major facilitator Superfamily
CWS50_RS06130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWS50_RS06135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWS50_RS06140	COG4770	biotin carboxylase activity
CWS50_RS06145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWS50_RS06155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWS50_RS06165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWS50_RS06170	COG0549	Belongs to the carbamate kinase family
CWS50_RS06190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWS50_RS06195	COG0477	Major facilitator Superfamily
CWS50_RS06205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWS50_RS06210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWS50_RS06220	COG1758	RNA polymerase activity
CWS50_RS06225	COG0194	GDP metabolic process
CWS50_RS06230	COG0194	GDP metabolic process
CWS50_RS06235	COG0284	orotidine-5'-phosphate decarboxylase activity
CWS50_RS06240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CWS50_RS06245	COG0540	Belongs to the ATCase OTCase family
CWS50_RS06250	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CWS50_RS06260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWS50_RS06265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWS50_RS06270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWS50_RS06280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWS50_RS06285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWS50_RS06290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWS50_RS06295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWS50_RS06300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWS50_RS06305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWS50_RS06310	COG0730	response to heat
CWS50_RS06320	COG2409	Drug exporters of the RND superfamily
CWS50_RS06325	COG0009	L-threonylcarbamoyladenylate synthase
CWS50_RS06330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWS50_RS06370	COG0124	histidyl-tRNA synthetase
CWS50_RS06395	COG1196	nuclear chromosome segregation
CWS50_RS06400	COG0789	Transcriptional regulator
CWS50_RS06410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWS50_RS06415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWS50_RS06420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWS50_RS06425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWS50_RS06435	COG2255	four-way junction helicase activity
CWS50_RS06440	COG0632	four-way junction helicase activity
CWS50_RS06445	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CWS50_RS06450	COG0217	transcriptional regulatory protein
CWS50_RS06455	COG0494	nUDIX hydrolase
CWS50_RS06460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CWS50_RS06475	COG0438	transferase activity, transferring glycosyl groups
CWS50_RS06480	COG1560	Kdo2-lipid A biosynthetic process
CWS50_RS06495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWS50_RS06500	COG0300	oxidoreductase activity
CWS50_RS06560	COG1882	Formate acetyltransferase
CWS50_RS06565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWS50_RS06580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWS50_RS06585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWS50_RS06600	COG0321	lipoyl(octanoyl) transferase activity
CWS50_RS06605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWS50_RS06615	COG0174	glutamine synthetase
CWS50_RS06625	COG0765	amino acid transport
CWS50_RS06630	COG1126	abc transporter atp-binding protein
CWS50_RS06635	COG0406	alpha-ribazole phosphatase activity
CWS50_RS06640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CWS50_RS06645	COG0174	glutamine synthetase
CWS50_RS06650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWS50_RS06690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWS50_RS06730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CWS50_RS06740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWS50_RS06785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWS50_RS06815	COG0358	DNA primase activity
CWS50_RS06830	COG2182	Extracellular solute-binding protein
CWS50_RS06835	COG1175	transmembrane transport
CWS50_RS06840	COG3833	ABC-type maltose transport systems, permease component
CWS50_RS06860	COG0667	Aldo Keto reductase
CWS50_RS06865	COG0167	dihydroorotate dehydrogenase activity
CWS50_RS06915	COG2151	metal-sulfur cluster biosynthetic enzyme
CWS50_RS06920	COG0822	iron-sulfur transferase activity
CWS50_RS06930	COG0396	ATPase activity
CWS50_RS06980	COG0497	DNA recombination
CWS50_RS06985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWS50_RS07000	COG0647	UMP catabolic process
CWS50_RS07025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CWS50_RS07035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWS50_RS07040	COG2094	Belongs to the DNA glycosylase MPG family
CWS50_RS07045	COG0165	Argininosuccinate lyase
CWS50_RS07055	COG0137	argininosuccinate synthase activity
CWS50_RS07060	COG1438	arginine binding
CWS50_RS07065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWS50_RS07070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWS50_RS07080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWS50_RS07105	COG1131	(ABC) transporter
CWS50_RS07120	COG0765	amino acid transport
CWS50_RS07125	COG0765	amino acid transport
CWS50_RS07135	COG1126	abc transporter atp-binding protein
CWS50_RS07155	COG2197	response regulator
CWS50_RS07165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWS50_RS07170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWS50_RS07175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWS50_RS07180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CWS50_RS07190	COG3845	ABC transporter
CWS50_RS07205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWS50_RS07210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWS50_RS07230	COG0131	Imidazoleglycerol-phosphate dehydratase
CWS50_RS07235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWS50_RS07240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWS50_RS07250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWS50_RS07265	COG0587	DNA-directed DNA polymerase activity
CWS50_RS07290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWS50_RS07295	COG3599	regulation of cell shape
CWS50_RS07305	COG1799	cell septum assembly
CWS50_RS07310	COG1496	oxidoreductase activity
CWS50_RS07315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWS50_RS07325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWS50_RS07335	COG0772	Belongs to the SEDS family
CWS50_RS07340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWS50_RS07345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWS50_RS07350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWS50_RS07355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWS50_RS07360	COG0768	penicillin binding
CWS50_RS07370	COG0275	rRNA processing
CWS50_RS07375	COG2001	Belongs to the MraZ family
CWS50_RS07385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWS50_RS07405	COG0318	PFAM AMP-dependent synthetase and ligase
CWS50_RS07410	COG0318	PFAM AMP-dependent synthetase and ligase
CWS50_RS07420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWS50_RS07440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWS50_RS07455	COG2274	protein secretion by the type I secretion system
CWS50_RS07480	COG2190	(PTS) system
CWS50_RS07480	COG1263	PTS System
CWS50_RS07480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWS50_RS07485	COG0612	Peptidase, M16
CWS50_RS07495	COG1185	polyribonucleotide nucleotidyltransferase activity
CWS50_RS07515	COG0196	riboflavin kinase activity
CWS50_RS07525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWS50_RS07530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWS50_RS07545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWS50_RS07545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWS50_RS07560	COG0779	Required for maturation of 30S ribosomal subunits
CWS50_RS07570	COG0442	prolyl-tRNA aminoacylation
CWS50_RS07595	COG2226	methyltransferase
CWS50_RS07600	COG0142	geranyltranstransferase activity
CWS50_RS07620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWS50_RS07625	COG0750	zinc metalloprotease
CWS50_RS07630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWS50_RS07640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWS50_RS07645	COG0575	Belongs to the CDS family
CWS50_RS07650	COG0233	cytoplasmic translational termination
CWS50_RS07660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWS50_RS07665	COG0052	Belongs to the universal ribosomal protein uS2 family
CWS50_RS07690	COG0792	nuclease activity
CWS50_RS07700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWS50_RS07710	COG0335	large ribosomal subunit rRNA binding
CWS50_RS07715	COG0681	Belongs to the peptidase S26 family
CWS50_RS07720	COG0336	Belongs to the RNA methyltransferase TrmD family
CWS50_RS07725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWS50_RS07730	COG1837	Belongs to the UPF0109 family
CWS50_RS07735	COG0228	four-way junction DNA binding
CWS50_RS07785	COG4152	abc transporter atp-binding protein
CWS50_RS07800	COG0105	UTP biosynthetic process
CWS50_RS07805	COG2188	Transcriptional regulator
CWS50_RS07810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWS50_RS07810	COG1263	PTS System
CWS50_RS07810	COG2190	(PTS) system
CWS50_RS07815	COG0366	Alpha amylase catalytic
CWS50_RS07820	COG0285	dihydrofolate synthase activity
CWS50_RS07855	COG2056	Na+-H+ antiporter family
CWS50_RS07860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWS50_RS07870	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CWS50_RS07880	COG1222	aaa ATPase
CWS50_RS07910	COG0366	Alpha amylase catalytic
CWS50_RS07925	COG1653	transport
CWS50_RS07940	COG1605	Chorismate mutase
CWS50_RS07940	COG0287	Prephenate dehydrogenase
CWS50_RS07945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWS50_RS07950	COG0740	serine-type endopeptidase activity
CWS50_RS07965	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWS50_RS07975	COG4988	ABC transporter
CWS50_RS08025	COG1739	Uncharacterized protein family UPF0029
CWS50_RS08035	COG1045	serine acetyltransferase
CWS50_RS08050	COG3590	peptidase
CWS50_RS08080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWS50_RS08130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CWS50_RS08170	COG2818	Glycosylase
CWS50_RS08200	COG4585	Histidine kinase
CWS50_RS08210	COG1132	(ABC) transporter
CWS50_RS08220	COG1132	(ABC) transporter
CWS50_RS08255	COG0513	Belongs to the DEAD box helicase family
CWS50_RS08265	COG0673	inositol 2-dehydrogenase activity
CWS50_RS08270	COG0006	proline dipeptidase activity
CWS50_RS08285	COG1082	Xylose isomerase domain protein TIM barrel
CWS50_RS08295	COG2239	Acts as a magnesium transporter
CWS50_RS08310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWS50_RS08325	COG1611	Belongs to the LOG family
CWS50_RS08330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWS50_RS08335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWS50_RS08350	COG1079	Belongs to the binding-protein-dependent transport system permease family
CWS50_RS08355	COG4603	Belongs to the binding-protein-dependent transport system permease family
CWS50_RS08360	COG3845	ABC transporter
CWS50_RS08365	COG1744	ABC transporter substrate-binding protein PnrA-like
CWS50_RS08370	COG0058	SHG alpha-glucan phosphorylase activity
CWS50_RS08410	COG0039	L-malate dehydrogenase activity
CWS50_RS08415	COG4988	ABC transporter
CWS50_RS08420	COG1132	(ABC) transporter
CWS50_RS08425	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CWS50_RS08465	COG0045	succinate-CoA ligase (ADP-forming) activity
CWS50_RS08495	COG0205	6-phosphofructokinase activity
CWS50_RS08510	COG2197	response regulator
CWS50_RS08520	COG0366	Alpha amylase catalytic
CWS50_RS08525	COG1501	Belongs to the glycosyl hydrolase 31 family
CWS50_RS08545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CWS50_RS08600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWS50_RS08605	COG0254	rRNA binding
CWS50_RS08645	COG0083	homoserine kinase activity
CWS50_RS08650	COG0460	homoserine dehydrogenase
CWS50_RS08665	COG0018	arginyl-trna synthetase
CWS50_RS08680	COG0584	glycerophosphoryl diester phosphodiesterase
CWS50_RS08685	COG0739	heme binding
CWS50_RS08695	COG1253	flavin adenine dinucleotide binding
CWS50_RS08700	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWS50_RS08700	COG0567	Dehydrogenase, E1 component
CWS50_RS08700	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWS50_RS08700	COG0567	Dehydrogenase, E1 component
CWS50_RS08715	COG1175	transmembrane transport
CWS50_RS08720	COG0395	ABC-type sugar transport system, permease component
CWS50_RS08730	COG5662	AntiSigma factor
CWS50_RS08735	COG1595	DNA-templated transcription, initiation
CWS50_RS08745	COG2838	Isocitrate dehydrogenase
CWS50_RS08750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWS50_RS08775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWS50_RS08790	COG0314	molybdopterin synthase activity
CWS50_RS08800	COG0315	cyclic pyranopterin monophosphate synthase activity
CWS50_RS08805	COG0746	molybdenum cofactor guanylyltransferase activity
CWS50_RS08815	COG0315	cyclic pyranopterin monophosphate synthase activity
CWS50_RS08815	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWS50_RS08830	COG1140	nitrate reductase beta subunit
CWS50_RS08855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWS50_RS08860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWS50_RS08875	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWS50_RS08880	COG0483	inositol monophosphate 1-phosphatase activity
CWS50_RS08885	COG1968	undecaprenyl-diphosphatase activity
CWS50_RS08890	COG0420	3'-5' exonuclease activity
CWS50_RS08895	COG0419	ATPase involved in DNA repair
CWS50_RS08980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWS50_RS08990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CWS50_RS08995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWS50_RS09000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWS50_RS09005	COG1053	succinate dehydrogenase
CWS50_RS09015	COG0456	acetyltransferase
CWS50_RS09020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWS50_RS09030	COG0802	atpase or kinase
CWS50_RS09035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWS50_RS09045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWS50_RS09050	COG1072	(Pantothenic acid kinase))
CWS50_RS09055	COG0667	Aldo Keto reductase
CWS50_RS09070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWS50_RS09075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWS50_RS09080	COG0101	tRNA pseudouridine synthase activity
CWS50_RS09090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CWS50_RS09095	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CWS50_RS09100	COG0203	ribosomal protein L17
CWS50_RS09105	COG0202	RNA polymerase activity
CWS50_RS09110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CWS50_RS09115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWS50_RS09120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWS50_RS09125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWS50_RS09135	COG0563	adenylate kinase activity
CWS50_RS09145	COG0200	Binds to the 23S rRNA
CWS50_RS09150	COG1841	ribosomal large subunit assembly
CWS50_RS09155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWS50_RS09165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWS50_RS09175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWS50_RS09180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWS50_RS09185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWS50_RS09190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWS50_RS09195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWS50_RS09200	COG0255	Belongs to the universal ribosomal protein uL29 family
CWS50_RS09205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWS50_RS09210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWS50_RS09215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWS50_RS09220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWS50_RS09225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWS50_RS09230	COG0089	rRNA binding
CWS50_RS09240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWS50_RS09245	COG0051	transcription antitermination factor activity, RNA binding
CWS50_RS09255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWS50_RS09260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWS50_RS09265	COG0049	tRNA binding
CWS50_RS09270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWS50_RS09285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWS50_RS09290	COG0085	RNA polymerase activity
CWS50_RS09295	COG0222	ribosome binding
CWS50_RS09300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWS50_RS09315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWS50_RS09320	COG0081	regulation of translation
CWS50_RS09325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWS50_RS09330	COG0250	Participates in transcription elongation, termination and antitermination
CWS50_RS09345	COG0436	Aminotransferase
CWS50_RS09360	COG1115	amino acid carrier protein
CWS50_RS09370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CWS50_RS09375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWS50_RS09390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWS50_RS09405	COG2017	converts alpha-aldose to the beta-anomer
CWS50_RS09410	COG1461	Dihydroxyacetone kinase
CWS50_RS09415	COG1461	Dihydroxyacetone kinase
CWS50_RS09420	COG2376	Dihydroxyacetone kinase
CWS50_RS09430	COG2390	Transcriptional regulator
CWS50_RS09435	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS09440	COG1129	ABC transporter
CWS50_RS09445	COG1879	ABC-type sugar transport system periplasmic component
CWS50_RS09450	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWS50_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS09460	COG3958	Transketolase
CWS50_RS09465	COG3959	Transketolase, thiamine diphosphate binding domain
CWS50_RS09475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWS50_RS09480	COG1879	ABC-type sugar transport system periplasmic component
CWS50_RS09485	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWS50_RS09490	COG1129	ABC transporter
CWS50_RS09500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWS50_RS09525	COG1609	Transcriptional regulator
CWS50_RS09530	COG1070	Carbohydrate kinase
CWS50_RS09535	COG2115	Belongs to the xylose isomerase family
CWS50_RS09540	COG1940	carbohydrate kinase activity
CWS50_RS09540	COG1846	Transcriptional regulator
CWS50_RS09575	COG1131	(ABC) transporter
CWS50_RS09585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CWS50_RS09600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CWS50_RS09620	COG1069	ribulokinase activity
CWS50_RS09625	COG0647	UMP catabolic process
CWS50_RS09635	COG0698	ribose 5-phosphate isomerase
CWS50_RS09645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CWS50_RS09650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWS50_RS09655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWS50_RS09660	COG1620	l-lactate permease
CWS50_RS09715	COG2814	Major facilitator Superfamily
CWS50_RS09725	COG0247	lactate metabolic process
CWS50_RS09730	COG1139	Iron-sulfur cluster binding protein
CWS50_RS09735	COG1556	Lactate utilization protein
CWS50_RS09745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWS50_RS09775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWS50_RS09780	COG3599	regulation of cell shape
CWS50_RS09805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWS50_RS09820	COG1136	(ABC) transporter
CWS50_RS09820	COG0577	efflux transmembrane transporter activity
CWS50_RS09825	COG1136	(ABC) transporter
CWS50_RS09825	COG0577	efflux transmembrane transporter activity
CWS50_RS09830	COG0577	efflux transmembrane transporter activity
CWS50_RS09830	COG1136	(ABC) transporter
CWS50_RS09870	COG1132	(ABC) transporter
CWS50_RS09900	COG0302	gtp cyclohydrolase
CWS50_RS09940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWS50_RS09965	COG2027	D-alanyl-D-alanine carboxypeptidase
CWS50_RS09970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CWS50_RS09975	COG0791	NLP P60 protein
CWS50_RS09980	COG2873	o-acetylhomoserine
CWS50_RS09985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWS50_RS10025	COG0714	Associated with various cellular activities
CWS50_RS10030	COG0574	Belongs to the PEP-utilizing enzyme family
CWS50_RS10030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWS50_RS10035	COG2161	toxin-antitoxin pair type II binding
CWS50_RS10065	COG0438	transferase activity, transferring glycosyl groups
CWS50_RS10065	COG0297	glycogen (starch) synthase activity
CWS50_RS10080	COG1012	belongs to the aldehyde dehydrogenase family
CWS50_RS10085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CWS50_RS10090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWS50_RS10100	COG1309	transcriptional regulator
CWS50_RS10105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWS50_RS10115	COG1490	D-aminoacyl-tRNA deacylase activity
CWS50_RS10125	COG0354	folic acid binding
CWS50_RS10130	COG3485	protocatechuate 3,4-dioxygenase
CWS50_RS10140	COG0745	RESPONSE REGULATOR receiver
CWS50_RS10145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWS50_RS10170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CWS50_RS10230	COG0513	Belongs to the DEAD box helicase family
CWS50_RS10295	COG1136	(ABC) transporter
CWS50_RS10300	COG0577	efflux transmembrane transporter activity
CWS50_RS10310	COG1132	(ABC) transporter
CWS50_RS10315	COG1132	(ABC) transporter
CWS50_RS10350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWS50_RS10365	COG4667	esterase of the alpha-beta hydrolase superfamily
CWS50_RS10370	COG1902	pentaerythritol trinitrate reductase activity
CWS50_RS10380	COG3012	SEC-C Motif Domain Protein
CWS50_RS10385	COG1362	aminopeptidase activity
CWS50_RS10420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWS50_RS10425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWS50_RS10425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWS50_RS10440	COG3059	membrane
CWS50_RS10600	COG1322	Protein conserved in bacteria
CWS50_RS10605	COG0833	amino acid
CWS50_RS10615	COG1570	exodeoxyribonuclease VII activity
CWS50_RS10620	COG1722	exodeoxyribonuclease VII activity
CWS50_RS10635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWS50_RS10645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWS50_RS10650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWS50_RS10660	COG0583	DNA-binding transcription factor activity
CWS50_RS10675	COG0431	NADPH-dependent FMN reductase
CWS50_RS10680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWS50_RS10685	COG4175	Glycine betaine
CWS50_RS10685	COG0517	IMP dehydrogenase activity
CWS50_RS10710	COG1124	(ABC) transporter
CWS50_RS10720	COG0129	dihydroxy-acid dehydratase activity
CWS50_RS10725	COG0545	Peptidyl-prolyl cis-trans isomerase
CWS50_RS10750	COG4585	Histidine kinase
CWS50_RS10755	COG2197	response regulator
CWS50_RS10780	COG0193	aminoacyl-tRNA hydrolase activity
CWS50_RS10785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CWS50_RS10790	COG0710	3-dehydroquinate dehydratase activity
CWS50_RS10810	COG0148	phosphopyruvate hydratase activity
CWS50_RS10815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWS50_RS10820	COG1535	isochorismatase
CWS50_RS10820	COG3433	isochorismatase activity
CWS50_RS10825	COG4592	Periplasmic binding protein
CWS50_RS10830	COG1120	ATPase activity
CWS50_RS10835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWS50_RS10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWS50_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS10870	COG0667	Aldo Keto reductase
CWS50_RS10880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CWS50_RS10885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWS50_RS10980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWS50_RS10990	COG0714	Associated with various cellular activities
CWS50_RS11030	COG0488	(ABC) transporter
CWS50_RS11035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWS50_RS11040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWS50_RS11055	COG0084	hydrolase, TatD family'
CWS50_RS11060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWS50_RS11075	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CWS50_RS11090	COG1414	Transcriptional regulator
CWS50_RS11095	COG1929	Belongs to the glycerate kinase type-1 family
CWS50_RS11105	COG1929	Belongs to the glycerate kinase type-1 family
CWS50_RS11110	COG1131	(ABC) transporter
CWS50_RS11120	COG0367	asparagine synthase
CWS50_RS11125	COG1045	serine acetyltransferase
CWS50_RS11130	COG1216	Glycosyl transferase, family 2
CWS50_RS11130	COG1442	glycosyl transferase family 8
CWS50_RS11145	COG2192	nodulation
CWS50_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
CWS50_RS11220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWS50_RS11230	COG1970	mechanosensitive ion channel activity
CWS50_RS11255	COG1388	LysM domain
CWS50_RS11255	COG0791	NLP P60 protein
CWS50_RS11255	COG3103	Sh3 type 3 domain protein
CWS50_RS11265	COG2252	PERMEase
CWS50_RS11280	COG1061	Type III restriction enzyme res subunit
CWS50_RS11295	COG1842	Phage shock protein A
CWS50_RS11305	COG0745	RESPONSE REGULATOR receiver
CWS50_RS11310	COG2205	protein histidine kinase activity
CWS50_RS11325	COG0459	protein refolding
CWS50_RS11340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWS50_RS11395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWS50_RS11400	COG0215	cysteine-tRNA ligase activity
CWS50_RS11420	COG3842	ATPase activity
CWS50_RS11470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWS50_RS11640	COG0542	response to heat
CWS50_RS11660	COG0789	Transcriptional regulator
CWS50_RS11665	COG0484	heat shock protein binding
CWS50_RS11670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWS50_RS11675	COG0443	Heat shock 70 kDa protein
CWS50_RS11715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWS50_RS11735	COG1609	Transcriptional regulator
CWS50_RS11740	COG2814	Major facilitator Superfamily
CWS50_RS11750	COG1070	Carbohydrate kinase
CWS50_RS11765	COG2814	Major facilitator Superfamily
CWS50_RS11775	COG3408	Glycogen debranching enzyme
CWS50_RS11805	COG0673	inositol 2-dehydrogenase activity
CWS50_RS11825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWS50_RS11830	COG1329	Transcriptional regulator
CWS50_RS11840	COG5002	protein histidine kinase activity
CWS50_RS11845	COG0704	Plays a role in the regulation of phosphate uptake
CWS50_RS11850	COG0588	phosphoglycerate mutase activity
CWS50_RS11865	COG1113	amino acid transport
CWS50_RS11870	COG0252	asparaginase activity
CWS50_RS11890	COG0470	DNA polymerase III
CWS50_RS11895	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWS50_RS11915	COG1131	(ABC) transporter
CWS50_RS11920	COG2188	Transcriptional regulator
CWS50_RS11930	COG2885	chlorophyll binding
CWS50_RS11935	COG3850	Histidine kinase
CWS50_RS11935	COG5002	protein histidine kinase activity
CWS50_RS11940	COG0745	RESPONSE REGULATOR receiver
CWS50_RS11950	COG1754	DNA topoisomerase type I activity
CWS50_RS11950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWS50_RS11970	COG2205	protein histidine kinase activity
CWS50_RS11995	COG2890	protein-(glutamine-N5) methyltransferase activity
CWS50_RS12000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWS50_RS12105	COG2197	response regulator
CWS50_RS12135	COG2894	cell division
CWS50_RS12170	COG2233	PERMEase
CWS50_RS12215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWS50_RS12225	COG1309	transcriptional regulator
CWS50_RS12230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWS50_RS12235	COG1464	Belongs to the NlpA lipoprotein family
CWS50_RS12240	COG2011	ABC-type metal ion transport system permease component
CWS50_RS12245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWS50_RS12285	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CWS50_RS12295	COG0785	Cytochrome C biogenesis protein
CWS50_RS12300	COG1333	cytochrome c biogenesis protein
CWS50_RS12305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWS50_RS12325	COG1131	(ABC) transporter
CWS50_RS12345	COG1131	(ABC) transporter
CWS50_RS12350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWS50_RS12355	COG1072	(Pantothenic acid kinase))
CWS50_RS12370	COG3265	gluconokinase activity
CWS50_RS12375	COG0477	Major facilitator Superfamily
CWS50_RS12395	COG1609	Transcriptional regulator
CWS50_RS12405	COG0395	ABC-type sugar transport system, permease component
CWS50_RS12410	COG1175	transmembrane transport
CWS50_RS12445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWS50_RS12455	COG1012	belongs to the aldehyde dehydrogenase family
CWS50_RS12470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWS50_RS12480	COG0471	metal ion transport
CWS50_RS12505	COG1780	Probably involved in ribonucleotide reductase function
CWS50_RS12535	COG3550	peptidyl-serine autophosphorylation
CWS50_RS12550	COG2169	Transcriptional regulator
CWS50_RS12550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWS50_RS12555	COG0351	phosphomethylpyrimidine kinase
CWS50_RS12565	COG1131	(ABC) transporter
CWS50_RS12575	COG0305	Participates in initiation and elongation during chromosome replication
CWS50_RS12585	COG0359	binds to the 23S rRNA
CWS50_RS12590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWS50_RS12595	COG0629	single-stranded DNA binding
CWS50_RS12600	COG0360	Binds together with S18 to 16S ribosomal RNA
CWS50_RS12605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWS50_RS12610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWS50_RS12620	COG1733	regulation of RNA biosynthetic process
CWS50_RS12630	COG2197	response regulator
CWS50_RS12645	COG1953	Uracil, thiamine, allantoin
CWS50_RS12650	COG3960	tartronate-semialdehyde synthase activity
CWS50_RS12660	COG3958	Transketolase
CWS50_RS12665	COG3959	Transketolase, thiamine diphosphate binding domain
CWS50_RS12675	COG0540	Belongs to the ATCase OTCase family
CWS50_RS12680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CWS50_RS12685	COG1953	Uracil, thiamine, allantoin
CWS50_RS12710	COG2272	Belongs to the type-B carboxylesterase lipase family
CWS50_RS12715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWS50_RS12735	COG3345	alpha-galactosidase
CWS50_RS12740	COG0673	inositol 2-dehydrogenase activity
CWS50_RS12745	COG1131	(ABC) transporter
CWS50_RS12755	COG0617	tRNA 3'-terminal CCA addition
CWS50_RS12770	COG0728	peptidoglycan biosynthetic process
CWS50_RS12775	COG0492	ferredoxin-NADP+ reductase activity
CWS50_RS12780	COG3118	belongs to the thioredoxin family
CWS50_RS12790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWS50_RS12795	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWS50_RS12805	COG1192	Involved in chromosome partitioning
CWS50_RS12810	COG0357	Ribosomal RNA small subunit methyltransferase G
CWS50_RS12820	COG0706	membrane insertase activity
CWS50_RS12825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWS50_RS12830	COG0594	ribonuclease P activity
CWS50_RS12835	COG0230	Belongs to the bacterial ribosomal protein bL34 family