locus-tag	class	description
CWT12_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
CWT12_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
CWT12_RS00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
CWT12_RS00020	ENOG4105K7N	UPF0232 protein
CWT12_RS00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CWT12_RS00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CWT12_RS00070	ENOG4105CV8	reductase
CWT12_RS00075	ENOG4105XBB	septation inhibitor protein
CWT12_RS00080	ENOG4108U4N	(sortase) family
CWT12_RS00085	ENOG4105D9P	serine threonine protein kinase
CWT12_RS00090	ENOG4107TPY	serine threonine protein kinase
CWT12_RS00095	ENOG4105CJN	penicillin-binding protein
CWT12_RS00110	ENOG4105HZM	Fha domain containing protein
CWT12_RS00115	ENOG4105TV9	FHA Domain-Containing protein
CWT12_RS00130	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
CWT12_RS00145	ENOG4107WGA	YidE YbjL
CWT12_RS00150	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
CWT12_RS00165	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
CWT12_RS00175	ENOG4105C8P	)-transporter
CWT12_RS00190	ENOG4105DSF	transport protein
CWT12_RS00215	ENOG4105E4C	Lytic transglycosylase catalytic
CWT12_RS00305	ENOG4105E0A	ABC, transporter
CWT12_RS00310	ENOG4108IHU	transport system permease protein
CWT12_RS00315	ENOG4105DQ5	transport system permease protein
CWT12_RS00325	ENOG4108UW5	maltose o-acetyltransferase
CWT12_RS00330	ENOG4105DKQ	ROK family
CWT12_RS00335	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
CWT12_RS00410	ENOG4105CIG	ABC transporter
CWT12_RS00460	ENOG4105VPX	protein, conserved in bacteria
CWT12_RS00470	ENOG4107QTF	adenylosuccinate lyase
CWT12_RS00490	ENOG41082T9	Membrane
CWT12_RS00495	ENOG4105CIH	Imidazole acetol-phosphate transaminase
CWT12_RS00515	ENOG4105KME	endoribonuclease L-psp
CWT12_RS00530	ENOG4105CB5	ATP-dependent DNA helicase recG
CWT12_RS00560	ENOG4105WYW	fructose-bisphosphate aldolase
CWT12_RS00585	ENOG4105CT4	transporter
CWT12_RS00610	ENOG4105KJF	protein tyrosine phosphatase
CWT12_RS00630	ENOG4108UMI	ABC transporter, permease
CWT12_RS00635	ENOG4105D01	(LipO)protein
CWT12_RS00645	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
CWT12_RS00650	ENOG4105C94	Transporter
CWT12_RS00655	ENOG4108Z6B	deaminase
CWT12_RS00700	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
CWT12_RS00775	ENOG4105EC2	ftsk spoIIIe
CWT12_RS00810	ENOG4108Z3G	3H domain protein
CWT12_RS00825	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CWT12_RS00835	ENOG4105C09	Bile acid
CWT12_RS00840	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
CWT12_RS00855	ENOG4105KAV	tspo and mbr like protein
CWT12_RS00860	ENOG4105DBI	uridine monophosphokinase
CWT12_RS00865	ENOG4105CI2	imidazolone-5-propionate hydrolase
CWT12_RS00885	ENOG4108NGU	Transcriptional regulator
CWT12_RS00900	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CWT12_RS00910	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
CWT12_RS00920	ENOG4105C4Y	ABC transporter
CWT12_RS00930	ENOG4105BZU	Histidine kinase
CWT12_RS00950	ENOG4107TE5	Lipid kinase
CWT12_RS00955	ENOG4105C5Q	Transcriptional regulator
CWT12_RS00960	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
CWT12_RS00970	ENOG4105EPJ	extracellular solute-binding protein family 1
CWT12_RS00975	ENOG4108TVJ	Nitroreductase
CWT12_RS01020	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
CWT12_RS01025	ENOG4107QKS	N-acylglucosamine 2-epimerase
CWT12_RS01040	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
CWT12_RS01050	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
CWT12_RS01060	ENOG4105C28	cystathionine
CWT12_RS01065	ENOG4105C87	Aminotransferase class I and II
CWT12_RS01085	ENOG4105BZ1	(ABC) transporter
CWT12_RS01125	ENOG4105D1H	recombination factor protein RarA
CWT12_RS01155	ENOG4107QRT	dEAD DEAH box helicase
CWT12_RS01160	ENOG4105DF6	Fe-S oxidoreductase
CWT12_RS01230	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
CWT12_RS01235	ENOG4108UCS	ABC, transporter
CWT12_RS01250	ENOG4105C12	Phosphoribosylglycinamide synthetase
CWT12_RS01255	ENOG4105C8V	SAICAR synthetase
CWT12_RS01275	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
CWT12_RS01280	ENOG4105Q84	sucrose synthase
CWT12_RS01295	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
CWT12_RS01310	ENOG4105D82	Glutamate dehydrogenase
CWT12_RS01315	ENOG4105CGH	5'-nucleotidase
CWT12_RS01325	ENOG4105E98	transcriptional regulator DeoR family
CWT12_RS01335	ENOG4105DM4	PTS System
CWT12_RS01350	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
CWT12_RS01370	ENOG4105BZ1	(ABC) transporter
CWT12_RS01380	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
CWT12_RS01390	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CWT12_RS01415	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS01420	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS01430	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
CWT12_RS01460	ENOG4105E0X	reductase
CWT12_RS01480	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
CWT12_RS01485	ENOG4105C6Z	Gluconate
CWT12_RS01540	ENOG4107QJE	Chromosome Partitioning Protein
CWT12_RS01550	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CWT12_RS01570	ENOG4108C33	Resolvase
CWT12_RS01690	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
CWT12_RS01710	ENOG4105BZ4	penicillin-binding protein
CWT12_RS01735	ENOG4105D74	hydrolase
CWT12_RS01740	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
CWT12_RS01750	ENOG4108UMN	azlc family
CWT12_RS01790	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
CWT12_RS01835	ENOG4105BZU	Histidine kinase
CWT12_RS01840	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CWT12_RS01850	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
CWT12_RS01860	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
CWT12_RS01880	ENOG4105HDK	L-asparaginase
CWT12_RS01895	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CWT12_RS01900	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
CWT12_RS01905	ENOG4105BZU	Histidine kinase
CWT12_RS01910	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CWT12_RS01915	ENOG4108VJ1	Transcriptional regulator (CarD family
CWT12_RS01920	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
CWT12_RS01930	ENOG4108ZHJ	Organic hydroperoxide resistance protein
CWT12_RS01955	ENOG4105BZ1	(ABC) transporter
CWT12_RS01960	ENOG4105BZ1	(ABC) transporter
CWT12_RS01970	ENOG4105G9B	Transcriptional regulator
CWT12_RS01995	ENOG4105CS2	ec 3.2.1.21
CWT12_RS02025	ENOG4105DSG	hydrolase family 43
CWT12_RS02055	ENOG4105EBR	Carboxylesterase
CWT12_RS02060	ENOG4105CT4	transporter
CWT12_RS02065	ENOG4105FKQ	transcriptional regulator
CWT12_RS02085	ENOG4105DET	Rhamnulokinase
CWT12_RS02165	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS02185	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
CWT12_RS02210	ENOG4105EMD	TRANSCRIPTIONal
CWT12_RS02240	ENOG4106ETB	IIa component
CWT12_RS02285	ENOG4105C7N	Xanthine uracil vitamin C permease
CWT12_RS02305	ENOG4105K4H	Nlp p60 protein
CWT12_RS02335	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
CWT12_RS02345	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
CWT12_RS02420	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
CWT12_RS02445	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
CWT12_RS02450	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
CWT12_RS02455	ENOG4105C5H	ABC transporter
CWT12_RS02500	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CWT12_RS02510	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
CWT12_RS02515	ENOG4105D3Q	Sugar transferase
CWT12_RS02520	ENOG4108IG5	Transcriptional regulator
CWT12_RS02570	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
CWT12_RS02575	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
CWT12_RS02605	ENOG4105PSV	Polysaccharide Biosynthesis Protein
CWT12_RS02625	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
CWT12_RS02645	ENOG4105FF2	Type I DHQase
CWT12_RS02650	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
CWT12_RS02660	ENOG4105WH1	Two component transcriptional regulator luxr family
CWT12_RS02695	ENOG4105C01	Dihydroxy-acid dehydratase
CWT12_RS02700	ENOG4105C7B	Threonine dehydratase
CWT12_RS02705	ENOG4108YYH	Nadph-dependent fmn reductase
CWT12_RS02720	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
CWT12_RS02725	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
CWT12_RS02735	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
CWT12_RS02740	ENOG4108IAB	Phoh family
CWT12_RS02745	ENOG4105D7K	pfkb domain protein
CWT12_RS02750	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
CWT12_RS02760	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
CWT12_RS02770	ENOG4108HKT	sucrose-6-phosphate hydrolase
CWT12_RS02775	ENOG4108HKT	sucrose-6-phosphate hydrolase
CWT12_RS02780	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS02785	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
CWT12_RS02790	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
CWT12_RS02805	ENOG4105C3G	gtp-binding protein
CWT12_RS02825	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
CWT12_RS02835	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
CWT12_RS02875	ENOG4107U9K	TROVE domain-containing protein
CWT12_RS02890	ENOG4105C0D	helicase
CWT12_RS02900	ENOG4105CVK	Glutamate decarboxylase
CWT12_RS02905	ENOG4105E5D	amino acid
CWT12_RS02915	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
CWT12_RS02935	ENOG4105DFM	M18 family aminopeptidase
CWT12_RS02940	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
CWT12_RS02945	ENOG4108NRW	Phospholipase, patatin family
CWT12_RS02965	ENOG4105VKD	bioY protein
CWT12_RS03000	ENOG4105CI3	gtp-binding protein typa
CWT12_RS03010	ENOG4108Z4U	Ferredoxin
CWT12_RS03065	ENOG4108RH7	phosphoglycerate mutase
CWT12_RS03075	ENOG4105D85	methylase
CWT12_RS03085	ENOG4105DA5	(ABC) transporter
CWT12_RS03090	ENOG4105WH1	Two component transcriptional regulator luxr family
CWT12_RS03125	ENOG4105E2Y	ABC, transporter
CWT12_RS03130	ENOG4105R3P	Inner membrane protein yagU
CWT12_RS03140	ENOG4107SIQ	Naphthoate synthase
CWT12_RS03155	ENOG4105P8F	nudix hydrolase
CWT12_RS03160	ENOG4105DBV	ornithine carbamoyltransferase
CWT12_RS03170	ENOG4107TCW	O-succinylbenzoate synthase
CWT12_RS03175	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
CWT12_RS03180	ENOG4105C0H	protease
CWT12_RS03190	ENOG4108638	50S ribosomal protein L36
CWT12_RS03195	ENOG4105NRA	50s ribosomal protein l31 type b
CWT12_RS03200	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
CWT12_RS03205	ENOG4105W0E	50S ribosomal protein L33
CWT12_RS03210	ENOG4105KDC	50s ribosomal protein l28
CWT12_RS03230	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
CWT12_RS03240	ENOG4108VWQ	crispr-associated protein
CWT12_RS03245	ENOG41060M0	Crispr-associated protein, cse4 family
CWT12_RS03265	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
CWT12_RS03270	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
CWT12_RS03285	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CWT12_RS03290	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CWT12_RS03310	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
CWT12_RS03315	ENOG4105DIH	basic membrane
CWT12_RS03320	ENOG4108JQ9	ABC transporter
CWT12_RS03325	ENOG4105UIB	(ABC) transporter
CWT12_RS03350	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
CWT12_RS03355	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
CWT12_RS03360	ENOG4108URH	decarboxylase
CWT12_RS03375	ENOG410630M	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
CWT12_RS03380	ENOG4105D1F	ATP-binding protein
CWT12_RS03390	ENOG4105CJW	magnesium transporter
CWT12_RS03400	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
CWT12_RS03410	ENOG4105EE0	oxidoreductase
CWT12_RS03420	ENOG41081FY	multiple antibiotic resistance (MarC)-related
CWT12_RS03425	ENOG4105C1J	atp-dependent rna helicase
CWT12_RS03510	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
CWT12_RS03550	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
CWT12_RS03565	ENOG4105C5Y	PTS System
CWT12_RS03580	ENOG4105E98	transcriptional regulator DeoR family
CWT12_RS03590	ENOG41061GT	Aldolase
CWT12_RS03595	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
CWT12_RS03600	ENOG4105C5I	Dehydrogenase
CWT12_RS03605	ENOG4105BZW	Glycerate kinase
CWT12_RS03610	ENOG4108KGH	TRANSCRIPTIONal
CWT12_RS03625	ENOG4108YZG	isomerase
CWT12_RS03635	ENOG4105D7W	serine acetyltransferase
CWT12_RS03645	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
CWT12_RS03670	ENOG4107QK5	Homocysteine s-methyltransferase
CWT12_RS03685	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
CWT12_RS03695	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
CWT12_RS03700	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
CWT12_RS03710	ENOG4105EWC	Purine nucleoside phosphorylase
CWT12_RS03735	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
CWT12_RS03750	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
CWT12_RS03760	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
CWT12_RS03775	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
CWT12_RS03780	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
CWT12_RS03785	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
CWT12_RS03795	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
CWT12_RS03805	ENOG4105CPF	Cell wall formation (By similarity)
CWT12_RS03815	ENOG4105VB9	50S ribosomal protein l28
CWT12_RS03820	ENOG4105DP4	dak2 domain fusion protein ylov
CWT12_RS03830	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
CWT12_RS03840	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
CWT12_RS03855	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
CWT12_RS03875	ENOG4108JJ8	(ABC) transporter
CWT12_RS03890	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
CWT12_RS03900	ENOG4105C03	ribonuclease
CWT12_RS03905	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
CWT12_RS03910	ENOG4105K46	50S ribosomal protein l27
CWT12_RS03915	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWT12_RS03925	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
CWT12_RS03935	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CWT12_RS03940	ENOG4105BZU	Histidine kinase
CWT12_RS03955	ENOG4105BZ1	(ABC) transporter
CWT12_RS03965	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
CWT12_RS03975	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
CWT12_RS03980	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
CWT12_RS03990	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
CWT12_RS03995	ENOG4105CVJ	phosphoglycerate mutase
CWT12_RS04010	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
CWT12_RS04015	ENOG4107TK4	histidinol-phosphate phosphatase
CWT12_RS04035	ENOG4108UW5	maltose o-acetyltransferase
CWT12_RS04040	ENOG4105E2A	Dehydrogenase
CWT12_RS04045	ENOG4105E0A	ABC, transporter
CWT12_RS04050	ENOG4108MES	Periplasmic binding protein
CWT12_RS04055	ENOG4105DQ5	transport system permease protein
CWT12_RS04060	ENOG4105TVJ	transport system, permease
CWT12_RS04085	ENOG4108IUE	nitrate reductase beta subunit
CWT12_RS04100	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CWT12_RS04115	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CWT12_RS04135	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CWT12_RS04150	ENOG4105CEI	nitrite reductase
CWT12_RS04160	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
CWT12_RS04165	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
CWT12_RS04170	ENOG4105E9K	Isocitrate dehydrogenase
CWT12_RS04180	ENOG4105EMN	RNA polymerase sigma factor
CWT12_RS04205	ENOG4105E4C	Lytic transglycosylase catalytic
CWT12_RS04210	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
CWT12_RS04215	ENOG4105EBR	Carboxylesterase
CWT12_RS04245	ENOG4105C75	arginyL-tRNA synthetase
CWT12_RS04250	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
CWT12_RS04275	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
CWT12_RS04285	ENOG4105VFB	Binds the 23S rRNA (By similarity)
CWT12_RS04290	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
CWT12_RS04320	ENOG4108IUK	alpha amylase, catalytic
CWT12_RS04325	ENOG4107RV5	Glycosyl hydrolase family 3 N-terminal domain protein
CWT12_RS04335	ENOG4105CG3	alpha amylase, catalytic region
CWT12_RS04340	ENOG4105CJQ	hydrolase, family 31
CWT12_RS04345	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS04355	ENOG4105E2R	ROK family
CWT12_RS04385	ENOG4105CTQ	phosphohexokinase
CWT12_RS04410	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
CWT12_RS04415	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
CWT12_RS04430	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
CWT12_RS04480	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
CWT12_RS04485	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
CWT12_RS04505	ENOG4105C10	Electron transfer flavoprotein
CWT12_RS04510	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
CWT12_RS04560	ENOG41063PX	domain protein
CWT12_RS04605	ENOG4105C9Q	fumarate hydratase class II
CWT12_RS04630	ENOG4105WJV	Binding-protein-dependent transport systems, inner membrane component
CWT12_RS04645	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS04650	ENOG4105CK5	oxidoreductase
CWT12_RS04655	ENOG4107TTA	Xylose isomerase domain protein TIM barrel
CWT12_RS04660	ENOG4107QNK	)-transporter
CWT12_RS04670	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
CWT12_RS04700	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
CWT12_RS04710	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CWT12_RS04715	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
CWT12_RS04720	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CWT12_RS04750	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
CWT12_RS04760	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
CWT12_RS04890	ENOG4105EC2	ftsk spoIIIe
CWT12_RS04895	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CWT12_RS04940	ENOG4107VEG	TrkA-N domain protein
CWT12_RS04945	ENOG4105C0X	amino acid
CWT12_RS04950	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CWT12_RS04955	ENOG4107QM5	aconitate hydratase
CWT12_RS04965	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
CWT12_RS04970	ENOG4105DDK	oxidoreductase, beta subunit
CWT12_RS04975	ENOG4105BZ8	glutamate synthase
CWT12_RS04985	ENOG4107QN2	dihydrolipoyl dehydrogenase
CWT12_RS04990	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
CWT12_RS04995	ENOG4108V1U	phospholipid-binding protein
CWT12_RS05015	ENOG4107104	thymidine kinase
CWT12_RS05045	ENOG4105C0B	DNA polymerase III (alpha subunit)
CWT12_RS05065	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
CWT12_RS05070	ENOG4105DSB	aldose 1-epimerase
CWT12_RS05100	ENOG4105CPC	Aldo Keto reductase
CWT12_RS05110	ENOG4105CUC	YeeE YedE family protein
CWT12_RS05125	ENOG4105CNN	ABC, transporter
CWT12_RS05130	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
CWT12_RS05140	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
CWT12_RS05155	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
CWT12_RS05160	ENOG4105E5F	proteasome
CWT12_RS05165	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
CWT12_RS05170	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
CWT12_RS05180	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
CWT12_RS05200	ENOG4105DK0	Indole-3-glycerol phosphate synthase
CWT12_RS05205	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
CWT12_RS05235	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
CWT12_RS05245	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
CWT12_RS05250	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
CWT12_RS05275	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
CWT12_RS05280	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
CWT12_RS05285	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
CWT12_RS05330	ENOG4108HCJ	Hydrolase
CWT12_RS05345	ENOG4105CID	antiterminator
CWT12_RS05350	ENOG4105C5Y	PTS System
CWT12_RS05360	ENOG4105NX3	Membrane
CWT12_RS05370	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
CWT12_RS05380	ENOG4105CIE	May be required for sporulation (By similarity)
CWT12_RS05385	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
CWT12_RS05390	ENOG4105BZA	Phosphoglycerate kinase
CWT12_RS05395	ENOG4105CP7	Triose-phosphate isomerase
CWT12_RS05420	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
CWT12_RS05435	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
CWT12_RS05440	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
CWT12_RS05445	ENOG4107QP8	phosphohexose isomerase
CWT12_RS05465	ENOG4105CRK	lysyL-tRNA synthetase
CWT12_RS05500	ENOG4105C0D	helicase
CWT12_RS05520	ENOG4107QHE	Choloylglycine hydrolase
CWT12_RS05540	ENOG4107QM2	Aldo Keto reductase
CWT12_RS05560	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
CWT12_RS05585	ENOG4105CPC	Aldo Keto reductase
CWT12_RS05610	ENOG4105C5Y	PTS System
CWT12_RS05615	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS05625	ENOG4105CTQ	phosphohexokinase
CWT12_RS05635	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
CWT12_RS05650	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
CWT12_RS05660	ENOG4107TMB	Transcriptional regulator
CWT12_RS05675	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
CWT12_RS05680	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
CWT12_RS05685	ENOG4107XKF	NMT1 THI5 Like Domain Protein
CWT12_RS05690	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
CWT12_RS05705	ENOG4105CK7	Sodium proline symporter
CWT12_RS05710	ENOG4105VDH	Dihydroxyacetone kinase
CWT12_RS05715	ENOG4108UTZ	Dihydroxyacetone kinase
CWT12_RS05720	ENOG4105CMT	Dihydroxyacetone kinase
CWT12_RS05730	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
CWT12_RS05735	ENOG4105D8K	carboxyl transferase
CWT12_RS05745	ENOG4105DJV	ribulose-phosphate 3-epimerase
CWT12_RS05755	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
CWT12_RS05770	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
CWT12_RS05780	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
CWT12_RS05785	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
CWT12_RS05795	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
CWT12_RS05805	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
CWT12_RS05815	ENOG4105CXT	aspartate transcarbamylase
CWT12_RS05820	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
CWT12_RS05825	ENOG410803B	Involved in the transcription termination process (By similarity)
CWT12_RS05830	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
CWT12_RS05840	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
CWT12_RS05845	ENOG4105D49	3-dehydroquinate synthase
CWT12_RS05855	ENOG4105E2X	shikimate dehydrogenase
CWT12_RS05865	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
CWT12_RS05875	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
CWT12_RS05885	ENOG4105HF0	Membrane
CWT12_RS05895	ENOG4107R13	MMPL domain protein
CWT12_RS05900	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
CWT12_RS05910	ENOG4105CPQ	Dehydrogenase
CWT12_RS05915	ENOG4105IE8	Alpha-ketoglutarate permease
CWT12_RS05930	ENOG4105C9M	aspartyl-trna synthetase
CWT12_RS05955	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
CWT12_RS05960	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
CWT12_RS05980	ENOG4105C99	atpase involved in dna repair
CWT12_RS06030	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
CWT12_RS06035	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
CWT12_RS06040	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
CWT12_RS06045	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
CWT12_RS06055	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
CWT12_RS06060	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
CWT12_RS06065	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
CWT12_RS06070	ENOG4105CDY	transcriptional regulatory protein
CWT12_RS06090	ENOG4105E2K	Glycosyl transferase (Group 1
CWT12_RS06110	ENOG4105C22	threonyL-tRNA synthetase
CWT12_RS06170	ENOG4105C6N	Formate acetyltransferase
CWT12_RS06175	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
CWT12_RS06190	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
CWT12_RS06215	ENOG4105D9P	serine threonine protein kinase
CWT12_RS06220	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
CWT12_RS06225	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
CWT12_RS06245	ENOG4105E5Q	amino acid AbC transporter
CWT12_RS06265	ENOG4108TGR	phosphatase
CWT12_RS06275	ENOG4105C5F	glutamine synthetase
CWT12_RS06280	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
CWT12_RS06290	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
CWT12_RS06315	ENOG4105EGD	dinuclear metal center protein, YbgI family
CWT12_RS06330	ENOG4105CHM	Aminotransferase
CWT12_RS06355	ENOG4108IJ0	Aspartate ammonia-lyase
CWT12_RS06365	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
CWT12_RS06390	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CWT12_RS06675	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
CWT12_RS06680	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
CWT12_RS06685	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
CWT12_RS06700	ENOG4105D56	permease protein
CWT12_RS06705	ENOG4105EG2	ABC transporter, permease
CWT12_RS06715	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS06725	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
CWT12_RS06735	ENOG4105CPC	Aldo Keto reductase
CWT12_RS06740	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
CWT12_RS06760	ENOG4107SWG	transcriptional regulator MERR family
CWT12_RS06765	ENOG4105CIG	ABC transporter
CWT12_RS06775	ENOG4105VG1	fes assembly suf system protein
CWT12_RS06780	ENOG4108UNV	SUF system FeS assembly protein, NifU family
CWT12_RS06790	ENOG4105C3K	feS assembly ATPase SufC
CWT12_RS06795	ENOG4105JRK	feS assembly protein SufD
CWT12_RS06815	ENOG4105DRS	transport system, permease
CWT12_RS06830	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS06860	ENOG4105DWF	phosphomethylpyrimidine kinase
CWT12_RS06870	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
CWT12_RS06875	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
CWT12_RS06890	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
CWT12_RS06895	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
CWT12_RS06910	ENOG4105VG9	Plasmid stabilization system
CWT12_RS06915	ENOG410684T	prevent-host-death family
CWT12_RS06960	ENOG4105C5H	ABC transporter
CWT12_RS07000	ENOG4105DKW	ABC transporter
CWT12_RS07010	ENOG4107QPH	glycogen) synthase
CWT12_RS07015	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
CWT12_RS07020	ENOG4105EAC	phosphoserine phosphatase
CWT12_RS07050	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
CWT12_RS07060	ENOG4105E2Y	ABC, transporter
CWT12_RS07065	ENOG4105CC5	ABC transporter
CWT12_RS07075	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
CWT12_RS07080	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
CWT12_RS07085	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
CWT12_RS07100	ENOG4105VZ8	Transcriptional regulator
CWT12_RS07105	ENOG410839S	Toxic component of a toxin-antitoxin (TA) module (By similarity)
CWT12_RS07110	ENOG4105CJ1	ABC, transporter
CWT12_RS07125	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
CWT12_RS07135	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
CWT12_RS07150	ENOG4105CIG	ABC transporter
CWT12_RS07155	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
CWT12_RS07170	ENOG4105DFA	alanine racemase domain protein
CWT12_RS07175	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
CWT12_RS07180	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
CWT12_RS07205	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
CWT12_RS07215	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
CWT12_RS07225	ENOG4108NEV	two component transcriptional regulator, LytTR family
CWT12_RS07235	ENOG4105K64	Glycosyl transferase, family 2
CWT12_RS07270	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
CWT12_RS07280	ENOG4105CRQ	synthase (Component I)
CWT12_RS07285	ENOG4105RGK	anthranilate synthase component ii
CWT12_RS07300	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
CWT12_RS07305	ENOG4105D63	family UPF0324
CWT12_RS07330	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
CWT12_RS07335	ENOG4105DPH	UPF0371 protein
CWT12_RS07350	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
CWT12_RS07355	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
CWT12_RS07370	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
CWT12_RS07380	ENOG4105D7A	ATP-binding protein
CWT12_RS07465	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
CWT12_RS07470	ENOG4108VX5	3-methyladenine DNA glycosylase
CWT12_RS07475	ENOG4105CH7	arginosuccinase
CWT12_RS07485	ENOG4105CDH	Citrulline--aspartate ligase
CWT12_RS07490	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
CWT12_RS07500	ENOG4105CAS	nag kinase
CWT12_RS07510	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
CWT12_RS07525	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
CWT12_RS07535	ENOG4105CIG	ABC transporter
CWT12_RS07570	ENOG4105DRP	amino acid AbC transporter
CWT12_RS07605	ENOG4108RWN	rrna methyltransferase
CWT12_RS07610	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
CWT12_RS07615	ENOG41084BS	50S ribosomal protein L35
CWT12_RS07620	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
CWT12_RS07630	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
CWT12_RS07635	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
CWT12_RS07665	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
CWT12_RS07695	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
CWT12_RS07710	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
CWT12_RS07735	ENOG410848D	S4 domain protein YaaA
CWT12_RS07745	ENOG4105C0B	DNA polymerase III (alpha subunit)
CWT12_RS07780	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
CWT12_RS07785	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
CWT12_RS07790	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
CWT12_RS07800	ENOG4105DFU	Cell wall formation (By similarity)
CWT12_RS07815	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
CWT12_RS07830	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
CWT12_RS07835	ENOG4105CJN	penicillin-binding protein
CWT12_RS07845	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
CWT12_RS07850	ENOG4108V6E	Cell division protein mraZ
CWT12_RS07880	ENOG4105CEY	Amp-dependent synthetase and ligase
CWT12_RS07885	ENOG4105CEY	Amp-dependent synthetase and ligase
CWT12_RS07890	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
CWT12_RS07900	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
CWT12_RS07915	ENOG4105C1V	Peptidase, M16
CWT12_RS07920	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
CWT12_RS07940	ENOG4105DTN	riboflavin biosynthesis protein ribF
CWT12_RS07945	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
CWT12_RS07950	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
CWT12_RS07960	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
CWT12_RS07970	ENOG4105CHV	Transcription elongation factor NusA
CWT12_RS07975	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
CWT12_RS07995	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
CWT12_RS08015	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
CWT12_RS08020	ENOG4105DZP	Membrane-associated zinc metalloprotease
CWT12_RS08025	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
CWT12_RS08035	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
CWT12_RS08045	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
CWT12_RS08050	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
CWT12_RS08055	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
CWT12_RS08060	ENOG4105CE9	30S ribosomal protein S2
CWT12_RS08070	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CWT12_RS08075	ENOG4105CIG	ABC transporter
CWT12_RS08105	ENOG41080R2	UPF0102 protein
CWT12_RS08115	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CWT12_RS08120	ENOG4107QYR	Signal peptidase i
CWT12_RS08130	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
CWT12_RS08135	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
CWT12_RS08140	ENOG41082KU	UPF0109 protein
CWT12_RS08165	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
CWT12_RS08175	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
CWT12_RS08180	ENOG4108IUX	(ABC) transporter
CWT12_RS08190	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
CWT12_RS08195	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
CWT12_RS08210	ENOG4105D3Q	Sugar transferase
CWT12_RS08230	ENOG4107TYR	Glycosyl Transferase
CWT12_RS08260	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
CWT12_RS08265	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
CWT12_RS08280	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
CWT12_RS08285	ENOG410635A	Membrane
CWT12_RS08295	ENOG4107414	GntR family transcriptional regulator
CWT12_RS08300	ENOG4105C5Y	PTS System
CWT12_RS08305	ENOG4105CG3	alpha amylase, catalytic region
CWT12_RS08315	ENOG4108TFM	Kinase, PfkB family
CWT12_RS08330	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
CWT12_RS08340	ENOG4107XU6	Glycosyl transferase (Group 1
CWT12_RS08360	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
CWT12_RS08395	ENOG4105CJ1	ABC, transporter
CWT12_RS08410	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
CWT12_RS08420	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
CWT12_RS08425	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
CWT12_RS08465	ENOG4108SDV	Periplasmic Protein
CWT12_RS08470	ENOG4107SJW	iron permease, FTR1
CWT12_RS08480	ENOG4107SQD	Transcriptional regulator, GntR family
CWT12_RS08490	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
CWT12_RS08495	ENOG4105CDA	abc transporter atp-binding protein
CWT12_RS08500	ENOG4107UBR	Extracellular solute-binding protein family 3
CWT12_RS08505	ENOG4108Q1T	ABC transporter
CWT12_RS08510	ENOG4105DRP	amino acid AbC transporter
CWT12_RS08525	ENOG4105KC9	Modulates RecA activity (By similarity)
CWT12_RS08530	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
CWT12_RS08540	ENOG4105WBV	Transcriptional regulator
CWT12_RS08545	ENOG4105CEV	competence damage-inducible protein
CWT12_RS08555	ENOG4107QZI	cell division protein FtsK
CWT12_RS08565	ENOG4105CN5	Metallo-Beta-Lactamase
CWT12_RS08600	ENOG4105C87	Aminotransferase class I and II
CWT12_RS08605	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
CWT12_RS08610	ENOG4105BZG	amino acid carrier protein
CWT12_RS08615	ENOG4105BZG	amino acid carrier protein
CWT12_RS08635	ENOG410901E	Membrane
CWT12_RS08675	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
CWT12_RS08680	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
CWT12_RS08700	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
CWT12_RS08710	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
CWT12_RS08730	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
CWT12_RS08745	ENOG4108426	dNA-binding protein
CWT12_RS08750	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
CWT12_RS08755	ENOG4105DKQ	ROK family
CWT12_RS08760	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
CWT12_RS08780	ENOG4105DEF	Extracellular solute-binding protein, family 5
CWT12_RS08805	ENOG4105NF4	modulator of drug activity
CWT12_RS08825	ENOG4105CPC	Aldo Keto reductase
CWT12_RS08830	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
CWT12_RS08845	ENOG4105CAK	Cell division ATP-binding protein ftsE
CWT12_RS08870	ENOG4105IDI	abc transporter atp-binding protein
CWT12_RS08885	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
CWT12_RS08895	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
CWT12_RS08925	ENOG4105W2C	Glycosyl transferase
CWT12_RS08945	ENOG4107SJB	teichoic acid biosynthesis
CWT12_RS08950	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
CWT12_RS08965	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
CWT12_RS08985	ENOG4107SJB	teichoic acid biosynthesis
CWT12_RS09000	ENOG4105CM2	brancheD-chain amino acid aminotransferase
CWT12_RS09005	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
CWT12_RS09015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
CWT12_RS09025	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
CWT12_RS09030	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
CWT12_RS09045	ENOG4105D0C	transport protein
CWT12_RS09050	ENOG41062VX	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
CWT12_RS09055	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
CWT12_RS09085	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
CWT12_RS09100	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
CWT12_RS09125	ENOG4105EYH	Exonuclease
CWT12_RS09165	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
CWT12_RS09175	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
CWT12_RS09180	ENOG4108MKR	lipoprotein lpqb
CWT12_RS09185	ENOG4105BZU	Histidine kinase
CWT12_RS09190	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CWT12_RS09205	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CWT12_RS09245	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
CWT12_RS09255	ENOG4105EIP	mannose-6-phosphate isomerase
CWT12_RS09275	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
CWT12_RS09290	ENOG4105CTC	Lipopolysaccharide biosynthesis protein-like protein
CWT12_RS09305	ENOG4105EY8	ABC transporter
CWT12_RS09335	ENOG4105CKK	Glycosyl transferase, family 2
CWT12_RS09375	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
CWT12_RS09460	ENOG4108KGH	TRANSCRIPTIONal
CWT12_RS09470	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
CWT12_RS09515	ENOG4107WR6	Maf-like protein
CWT12_RS09525	ENOG4105WDJ	50S ribosomal protein L33
CWT12_RS09550	ENOG4105D0M	Protease HtpX homolog
CWT12_RS09580	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CWT12_RS09590	ENOG4105D65	subunit l
CWT12_RS09595	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CWT12_RS09600	ENOG41087XN	oxidoreductase
CWT12_RS09605	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CWT12_RS09610	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
CWT12_RS09615	ENOG4108IEH	NADH dehydrogenase subunit g
CWT12_RS09620	ENOG4107QIZ	NADH dehydrogenase
CWT12_RS09630	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CWT12_RS09635	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CWT12_RS09640	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CWT12_RS09650	ENOG4105P52	geranylgeranyl reductase
CWT12_RS09655	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
CWT12_RS09660	ENOG4105E4F	Isochorismate synthase
CWT12_RS09680	ENOG4105CE4	GlcNAc 6-P deacetylase
CWT12_RS09690	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
CWT12_RS09705	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
CWT12_RS09710	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
CWT12_RS09715	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
CWT12_RS09720	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
CWT12_RS09735	ENOG4105ZA1	atp synthase
CWT12_RS09740	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
CWT12_RS09750	ENOG4105ESV	Glycosyl transferase, family 4
CWT12_RS09765	ENOG4105WH1	Two component transcriptional regulator luxr family
CWT12_RS09795	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CWT12_RS09810	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
CWT12_RS09845	ENOG4107RSM	transcriptional regulator
CWT12_RS09855	ENOG4105CV8	reductase
CWT12_RS09870	ENOG4105CHR	reductase
CWT12_RS09885	ENOG4105CJ1	ABC, transporter
CWT12_RS09900	ENOG4105ENX	hydrolase
CWT12_RS09915	ENOG4105C2J	ABC transporter
CWT12_RS09920	ENOG4105CNN	ABC, transporter
CWT12_RS09935	ENOG4105CPC	Aldo Keto reductase
CWT12_RS09965	ENOG4105ST3	Transcriptional regulator
CWT12_RS10020	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
CWT12_RS10030	ENOG4105CPQ	Dehydrogenase
CWT12_RS10035	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS10040	ENOG4107QNK	)-transporter
CWT12_RS10045	ENOG4107QNK	)-transporter
CWT12_RS10050	ENOG4105F0H	myo-inositol catabolism protein
CWT12_RS10055	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
CWT12_RS10065	ENOG4105C26	Dehydrogenase
CWT12_RS10070	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
CWT12_RS10075	ENOG4105DH8	myo-inositol catabolism
CWT12_RS10095	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
CWT12_RS10105	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS10125	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
CWT12_RS10130	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CWT12_RS10135	ENOG410849S	phosphocarrier protein (HPr)
CWT12_RS10145	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
CWT12_RS10170	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CWT12_RS10175	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
CWT12_RS10180	ENOG4108UB4	uncharacterized protein ygjQ
CWT12_RS10195	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CWT12_RS10205	ENOG4105E33	succinate dehydrogenase
CWT12_RS10230	ENOG4108097	ATP-binding protein
CWT12_RS10235	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
CWT12_RS10255	ENOG4105BZU	Histidine kinase
CWT12_RS10260	ENOG4105WH1	Two component transcriptional regulator luxr family
CWT12_RS10270	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
CWT12_RS10275	ENOG4105CS9	pantothenic acid kinase
CWT12_RS10290	ENOG4105KVH	Transcriptional regulator
CWT12_RS10295	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
CWT12_RS10300	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
CWT12_RS10325	ENOG4108UJD	30S ribosomal protein S9
CWT12_RS10330	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
CWT12_RS10335	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
CWT12_RS10340	ENOG4105DKQ	ROK family
CWT12_RS10345	ENOG4108ZT0	50S ribosomal protein l17
CWT12_RS10350	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CWT12_RS10360	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWT12_RS10365	ENOG41067V7	50S ribosomal protein L36
CWT12_RS10370	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
CWT12_RS10380	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
CWT12_RS10385	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
CWT12_RS10390	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
CWT12_RS10400	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
CWT12_RS10405	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
CWT12_RS10410	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
CWT12_RS10415	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
CWT12_RS10420	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
CWT12_RS10425	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWT12_RS10430	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
CWT12_RS10435	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
CWT12_RS10445	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
CWT12_RS10450	ENOG41082SA	50s ribosomal protein l29
CWT12_RS10455	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
CWT12_RS10460	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
CWT12_RS10465	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
CWT12_RS10475	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWT12_RS10480	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
CWT12_RS10485	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
CWT12_RS10490	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
CWT12_RS10495	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
CWT12_RS10500	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
CWT12_RS10505	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
CWT12_RS10510	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
CWT12_RS10515	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
CWT12_RS10535	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
CWT12_RS10545	ENOG4105GSW	
CWT12_RS10610	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CWT12_RS10620	ENOG4108VZM	50s ribosomal protein L10
CWT12_RS10625	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
CWT12_RS10640	ENOG4108QVN	serine threonine protein kinase
CWT12_RS10645	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
CWT12_RS10650	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
CWT12_RS10655	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
CWT12_RS10695	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
CWT12_RS10700	ENOG4107R4N	Cell wall formation (By similarity)
CWT12_RS10720	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
CWT12_RS10725	ENOG4106Z5D	Glycoside Hydrolase Family 43
CWT12_RS10735	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS10750	ENOG4105CZN	Potassium uptake protein
CWT12_RS10790	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
CWT12_RS10800	ENOG4105I82	acetyl xylan esterase
CWT12_RS10810	ENOG4108HWW	ABC transporter
CWT12_RS10820	ENOG4105DFW	ABC transporter
CWT12_RS10825	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS10830	ENOG4107WI4	Aldose-1-epimerase
CWT12_RS10840	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS10845	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS10855	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
CWT12_RS10890	ENOG4105C5X	domain protein
CWT12_RS10900	ENOG4105KVH	Transcriptional regulator
CWT12_RS10905	ENOG4105C4C	beta-galactosidase
CWT12_RS10920	ENOG4105DRS	transport system, permease
CWT12_RS10930	ENOG4105ETE	Transcriptional regulator (LacI family
CWT12_RS10935	ENOG4108HWW	ABC transporter
CWT12_RS10985	ENOG4105C93	Xylose Isomerase
CWT12_RS10990	ENOG4105E2R	ROK family
CWT12_RS11005	ENOG4105CPC	Aldo Keto reductase
CWT12_RS11010	ENOG4105CMT	Dihydroxyacetone kinase
CWT12_RS11015	ENOG4105CMT	Dihydroxyacetone kinase
CWT12_RS11025	ENOG4105DT3	PTS system, galactitol-specific IIc component
CWT12_RS11050	ENOG4108IPW	abc transporter atp-binding protein
CWT12_RS11055	ENOG4105CM4	permease protein
CWT12_RS11100	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
CWT12_RS11120	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
CWT12_RS11135	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
CWT12_RS11140	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
CWT12_RS11145	ENOG4105DAA	L-lactate
CWT12_RS11155	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
CWT12_RS11160	ENOG4107QR9	Iron-sulfur cluster binding protein
CWT12_RS11165	ENOG41080R8	Conserved Protein
CWT12_RS11175	ENOG4105IE8	Alpha-ketoglutarate permease
CWT12_RS11190	ENOG410907W	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport
CWT12_RS11235	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CWT12_RS11260	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
CWT12_RS11275	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
CWT12_RS11295	ENOG4105EEI	dihydropteroate synthase
CWT12_RS11300	ENOG4105EUJ	GTP cyclohydrolase i
CWT12_RS11305	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CWT12_RS11375	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
CWT12_RS11400	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
CWT12_RS11410	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
CWT12_RS11415	ENOG4105F0N	pyrophosphate phospho-hydrolase
CWT12_RS11420	ENOG4105ZXU	NLP P60 protein
CWT12_RS11425	ENOG4108IQK	o-acetylhomoserine
CWT12_RS11430	ENOG4105DWV	Homoserine O-trans-acetylase
CWT12_RS11450	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CWT12_RS11475	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
CWT12_RS11500	ENOG4108UVJ	appr-1-p processing domain protein
CWT12_RS11510	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
CWT12_RS11520	ENOG4105EDR	glucose galactose transporter
CWT12_RS11530	ENOG4105K34	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound
CWT12_RS11545	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
CWT12_RS11555	ENOG4107NHD	transcriptional regulator
CWT12_RS11560	ENOG4105C2C	drug resistance transporter, Bcr CflA
CWT12_RS11570	ENOG4105CKK	Glycosyl transferase, family 2
CWT12_RS11580	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CWT12_RS11770	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CWT12_RS11785	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
CWT12_RS11795	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
CWT12_RS11840	ENOG4107RCW	fructose-bisphosphate aldolase
CWT12_RS11865	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
CWT12_RS11900	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
CWT12_RS11910	ENOG4105EMU	Dehydrogenase
CWT12_RS11920	ENOG4107S1E	Beta-lactamase
CWT12_RS11925	ENOG4108DBC	nitroreductase
CWT12_RS11930	ENOG4107S1V	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
CWT12_RS11955	ENOG4105DHP	deoxycytidine triphosphate deaminase
CWT12_RS11975	ENOG4105M6F	mutator MutT protein
CWT12_RS12035	ENOG4108ZF3	Phosphatase
CWT12_RS12050	ENOG4108VJY	integral membrane protein
CWT12_RS12075	ENOG4105BZ1	(ABC) transporter
CWT12_RS12080	ENOG4108JJ9	ABC, transporter
CWT12_RS12090	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CWT12_RS12095	ENOG4105BZU	Histidine kinase
CWT12_RS12105	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CWT12_RS12110	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CWT12_RS12165	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
CWT12_RS12175	ENOG4107T65	Integrase
CWT12_RS12475	ENOG4105WXW	Antirepressor
CWT12_RS12545	ENOG4105C8N	cysteinyl-tRNA synthetase
CWT12_RS12550	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
CWT12_RS12555	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
CWT12_RS12570	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
CWT12_RS12590	ENOG4108KBJ	Inner membrane protein YkgB
CWT12_RS12600	ENOG4105ETZ	PTS System
CWT12_RS12620	ENOG4108HKT	sucrose-6-phosphate hydrolase
CWT12_RS12620	ENOG4108HKT	sucrose-6-phosphate hydrolase
CWT12_RS12630	ENOG4106EES	
CWT12_RS12640	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
CWT12_RS12680	ENOG4105KNI	merR family transcriptional Regulator
CWT12_RS12685	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
CWT12_RS12690	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWT12_RS12695	ENOG4105CFG	Acts as a chaperone (By similarity)
CWT12_RS12700	ENOG4105CPC	Aldo Keto reductase
CWT12_RS12705	ENOG4107RCM	Releases the N-terminal proline from various substrates (By similarity)
CWT12_RS12730	ENOG4107TE5	Lipid kinase
CWT12_RS12755	ENOG4105CE1	Ferrous iron transport protein b
CWT12_RS12780	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CWT12_RS12800	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
CWT12_RS12805	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
CWT12_RS12825	ENOG4105D52	delta-aminolevulinic acid dehydratase
CWT12_RS12830	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
CWT12_RS12850	ENOG41080RH	Thioredoxin
CWT12_RS12860	ENOG4108SGK	Tetr family transcriptional regulator
CWT12_RS12930	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
CWT12_RS13000	ENOG4105C2W	permease
CWT12_RS13025	ENOG4107QW3	Sucrose phosphorylase
CWT12_RS13030	ENOG4105KVH	Transcriptional regulator
CWT12_RS13040	ENOG4105DWF	phosphomethylpyrimidine kinase
CWT12_RS13045	ENOG4105CDU	Replicative dna helicase
CWT12_RS13050	ENOG4105UQX	Mate efflux family protein
CWT12_RS13055	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
CWT12_RS13060	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
CWT12_RS13070	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
CWT12_RS13075	ENOG4105BZ4	penicillin-binding protein
CWT12_RS13080	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
CWT12_RS13125	ENOG4108JQ1	Dehydrogenase
CWT12_RS13130	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
CWT12_RS13160	ENOG4105CB5	ATP-dependent DNA helicase recG
CWT12_RS13195	ENOG4105C3M	thioredoxin reductase
CWT12_RS13200	ENOG4105K63	Thioredoxin
CWT12_RS13205	ENOG4105D98	threonine synthase
CWT12_RS13210	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
CWT12_RS13215	ENOG4105CPF	Cell wall formation (By similarity)
CWT12_RS13225	ENOG4107QJE	Chromosome Partitioning Protein
CWT12_RS13230	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
CWT12_RS13240	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CWT12_RS13245	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
CWT12_RS13255	ENOG41084CH	50S ribosomal protein l34
CWT12_RS13260	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
CWT12_RS13265	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
CWT12_RS13270	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)