locus-tag	class	description
CWT12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWT12_RS00010	COG0592	DNA-directed DNA polymerase activity
CWT12_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWT12_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CWT12_RS00025	COG0187	DNA topoisomerase II activity
CWT12_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWT12_RS00070	COG0656	L-ascorbic acid biosynthetic process
CWT12_RS00080	COG3764	Sortase (surface protein transpeptidase)
CWT12_RS00090	COG0515	serine threonine protein kinase
CWT12_RS00095	COG0768	penicillin binding
CWT12_RS00110	COG1716	ATPase activity
CWT12_RS00115	COG1716	ATPase activity
CWT12_RS00130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CWT12_RS00145	COG2985	domain, Protein
CWT12_RS00145	COG0569	domain protein
CWT12_RS00150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWT12_RS00165	COG1854	S-ribosylhomocysteine lyase activity
CWT12_RS00175	COG0471	metal ion transport
CWT12_RS00190	COG0628	permease
CWT12_RS00195	COG2226	methyltransferase
CWT12_RS00215	COG0741	lytic transglycosylase activity
CWT12_RS00215	COG1196	nuclear chromosome segregation
CWT12_RS00215	COG0739	heme binding
CWT12_RS00305	COG1120	ATPase activity
CWT12_RS00310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_RS00315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_RS00325	COG0110	maltose O-acetyltransferase activity
CWT12_RS00330	COG1940	carbohydrate kinase activity
CWT12_RS00335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWT12_RS00335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWT12_RS00435	COG1131	(ABC) transporter
CWT12_RS00460	COG1937	Protein conserved in bacteria
CWT12_RS00470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWT12_RS00490	COG1950	PFAM Membrane protein of
CWT12_RS00495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWT12_RS00560	COG3588	fructose-bisphosphate aldolase
CWT12_RS00585	COG2211	Major facilitator Superfamily
CWT12_RS00610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWT12_RS00630	COG2011	ABC-type metal ion transport system permease component
CWT12_RS00635	COG1464	Belongs to the NlpA lipoprotein family
CWT12_RS00645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWT12_RS00650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWT12_RS00655	COG0037	tRNA processing
CWT12_RS00655	COG0590	tRNA wobble adenosine to inosine editing
CWT12_RS00700	COG0519	Catalyzes the synthesis of GMP from XMP
CWT12_RS00700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWT12_RS00775	COG1674	ftsk spoiiie
CWT12_RS00810	COG1827	regulation of RNA biosynthetic process
CWT12_RS00825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWT12_RS00835	COG0385	Bile acid
CWT12_RS00840	COG3386	PFAM SMP-30 Gluconolaconase
CWT12_RS00850	COG1253	flavin adenine dinucleotide binding
CWT12_RS00855	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CWT12_RS00860	COG0572	uridine kinase
CWT12_RS00865	COG1228	amidohydrolase
CWT12_RS00885	COG1378	Sugar-specific transcriptional regulator TrmB
CWT12_RS00900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWT12_RS00910	COG3842	ATPase activity
CWT12_RS00915	COG1178	ABC-type Fe3 transport system permease component
CWT12_RS00920	COG1840	ABC-type Fe3 transport system, periplasmic component
CWT12_RS00930	COG3852	Histidine kinase
CWT12_RS00960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWT12_RS00970	COG1653	transport
CWT12_RS00975	COG0778	Nitroreductase
CWT12_RS01020	COG0778	Nitroreductase
CWT12_RS01040	COG1404	Belongs to the peptidase S8 family
CWT12_RS01060	COG0626	cystathionine gamma-synthase activity
CWT12_RS01065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWT12_RS01085	COG1132	(ABC) transporter
CWT12_RS01125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWT12_RS01155	COG1201	RNA secondary structure unwinding
CWT12_RS01160	COG0247	lactate metabolic process
CWT12_RS01160	COG2181	nitrate reductase activity
CWT12_RS01230	COG1175	transmembrane transport
CWT12_RS01235	COG3842	ATPase activity
CWT12_RS01250	COG0151	Belongs to the GarS family
CWT12_RS01255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWT12_RS01275	COG0047	phosphoribosylformylglycinamidine synthase activity
CWT12_RS01280	COG0438	transferase activity, transferring glycosyl groups
CWT12_RS01295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWT12_RS01310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWT12_RS01315	COG0737	Belongs to the 5'-nucleotidase family
CWT12_RS01325	COG1349	DNA-binding transcription factor activity
CWT12_RS01335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWT12_RS01335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_RS01335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWT12_RS01340	COG4085	toxin activity
CWT12_RS01340	COG0737	Belongs to the 5'-nucleotidase family
CWT12_RS01340	COG1525	nuclease
CWT12_RS01350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWT12_RS01370	COG1132	(ABC) transporter
CWT12_RS01380	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWT12_RS01425	COG2723	6-phospho-beta-galactosidase activity
CWT12_RS01430	COG0395	ABC-type sugar transport system, permease component
CWT12_RS01460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWT12_RS01480	COG3265	gluconokinase activity
CWT12_RS01540	COG1192	Involved in chromosome partitioning
CWT12_RS01550	COG4974	Belongs to the 'phage' integrase family
CWT12_RS01690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CWT12_RS01705	COG1408	metallophosphoesterase
CWT12_RS01710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWT12_RS01735	COG0596	Alpha beta hydrolase
CWT12_RS01740	COG1780	Probably involved in ribonucleotide reductase function
CWT12_RS01750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWT12_RS01790	COG1492	cobalamin metabolic process
CWT12_RS01835	COG2205	protein histidine kinase activity
CWT12_RS01840	COG0745	RESPONSE REGULATOR receiver
CWT12_RS01850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWT12_RS01850	COG1754	DNA topoisomerase type I activity
CWT12_RS01860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWT12_RS01880	COG0252	asparaginase activity
CWT12_RS01895	COG0588	phosphoglycerate mutase activity
CWT12_RS01900	COG0704	Plays a role in the regulation of phosphate uptake
CWT12_RS01905	COG5002	protein histidine kinase activity
CWT12_RS01910	COG0745	RESPONSE REGULATOR receiver
CWT12_RS01915	COG1329	Transcriptional regulator
CWT12_RS01920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWT12_RS01930	COG1764	response to oxidative stress
CWT12_RS01955	COG1132	(ABC) transporter
CWT12_RS01960	COG1132	(ABC) transporter
CWT12_RS01970	COG2508	Transcriptional regulator
CWT12_RS01995	COG2723	6-phospho-beta-galactosidase activity
CWT12_RS02025	COG3507	Belongs to the glycosyl hydrolase 43 family
CWT12_RS02030	COG3250	beta-galactosidase activity
CWT12_RS02040	COG2211	Major facilitator Superfamily
CWT12_RS02050	COG3250	beta-galactosidase activity
CWT12_RS02055	COG2272	Belongs to the type-B carboxylesterase lipase family
CWT12_RS02060	COG2211	Major facilitator Superfamily
CWT12_RS02065	COG1609	Transcriptional regulator
CWT12_RS02085	COG1070	Carbohydrate kinase
CWT12_RS02095	COG2814	Major facilitator Superfamily
CWT12_RS02165	COG1609	Transcriptional regulator
CWT12_RS02185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWT12_RS02210	COG3711	transcriptional antiterminator
CWT12_RS02210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_RS02240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_RS02250	COG1842	Phage shock protein A
CWT12_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
CWT12_RS02265	COG0604	alcohol dehydrogenase
CWT12_RS02265	COG3321	synthase
CWT12_RS02285	COG2252	PERMEase
CWT12_RS02305	COG0791	NLP P60 protein
CWT12_RS02335	COG1970	mechanosensitive ion channel activity
CWT12_RS02345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWT12_RS02420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWT12_RS02445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWT12_RS02450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWT12_RS02455	COG0488	(ABC) transporter
CWT12_RS02500	COG0714	Associated with various cellular activities
CWT12_RS02510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWT12_RS02510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CWT12_RS02515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWT12_RS02520	COG1309	transcriptional regulator
CWT12_RS02570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWT12_RS02605	COG2244	polysaccharide biosynthetic process
CWT12_RS02625	COG0148	phosphopyruvate hydratase activity
CWT12_RS02645	COG0710	3-dehydroquinate dehydratase activity
CWT12_RS02650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CWT12_RS02660	COG2197	response regulator
CWT12_RS02695	COG0129	dihydroxy-acid dehydratase activity
CWT12_RS02700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWT12_RS02705	COG0431	NADPH-dependent FMN reductase
CWT12_RS02720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWT12_RS02725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWT12_RS02735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWT12_RS02740	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CWT12_RS02750	COG1722	exodeoxyribonuclease VII activity
CWT12_RS02755	COG4209	transmembrane transport
CWT12_RS02760	COG0395	ABC-type sugar transport system, permease component
CWT12_RS02770	COG1621	beta-fructofuranosidase activity
CWT12_RS02785	COG1570	exodeoxyribonuclease VII activity
CWT12_RS02790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWT12_RS02805	COG0012	GTP binding
CWT12_RS02835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CWT12_RS02875	COG2304	oxidoreductase activity
CWT12_RS02890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWT12_RS02900	COG0076	glutamate decarboxylase activity
CWT12_RS02905	COG0531	amino acid
CWT12_RS02915	COG0546	phosphoglycolate phosphatase activity
CWT12_RS02935	COG1362	aminopeptidase activity
CWT12_RS02940	COG1902	pentaerythritol trinitrate reductase activity
CWT12_RS02945	COG4667	esterase of the alpha-beta hydrolase superfamily
CWT12_RS02965	COG1268	BioY protein
CWT12_RS03050	COG1053	succinate dehydrogenase
CWT12_RS03065	COG0406	alpha-ribazole phosphatase activity
CWT12_RS03075	COG1002	Type II restriction enzyme, methylase subunits
CWT12_RS03085	COG1131	(ABC) transporter
CWT12_RS03090	COG2197	response regulator
CWT12_RS03125	COG1116	anion transmembrane transporter activity
CWT12_RS03130	COG3477	response to acidic pH
CWT12_RS03140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWT12_RS03160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWT12_RS03170	COG4948	Mandelate Racemase Muconate Lactonizing
CWT12_RS03175	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CWT12_RS03180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWT12_RS03190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWT12_RS03195	COG0254	rRNA binding
CWT12_RS03200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWT12_RS03205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWT12_RS03210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWT12_RS03230	COG1518	maintenance of DNA repeat elements
CWT12_RS03245	COG1857	crispr-associated protein
CWT12_RS03265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWT12_RS03270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWT12_RS03280	COG1254	Belongs to the acylphosphatase family
CWT12_RS03285	COG0577	efflux transmembrane transporter activity
CWT12_RS03285	COG1136	(ABC) transporter
CWT12_RS03290	COG1136	(ABC) transporter
CWT12_RS03290	COG0577	efflux transmembrane transporter activity
CWT12_RS03350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWT12_RS03355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWT12_RS03360	COG1611	Belongs to the LOG family
CWT12_RS03375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWT12_RS03380	COG2151	metal-sulfur cluster biosynthetic enzyme
CWT12_RS03380	COG0489	protein tyrosine kinase activity
CWT12_RS03390	COG2239	Acts as a magnesium transporter
CWT12_RS03400	COG1082	Xylose isomerase domain protein TIM barrel
CWT12_RS03410	COG0673	inositol 2-dehydrogenase activity
CWT12_RS03420	COG2095	MarC family integral membrane protein
CWT12_RS03425	COG0513	Belongs to the DEAD box helicase family
CWT12_RS03510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CWT12_RS03550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWT12_RS03555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_RS03565	COG2190	(PTS) system
CWT12_RS03580	COG1349	DNA-binding transcription factor activity
CWT12_RS03590	COG1830	Aldolase
CWT12_RS03600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWT12_RS03605	COG1929	Belongs to the glycerate kinase type-1 family
CWT12_RS03610	COG1316	TRANSCRIPTIONal
CWT12_RS03625	COG0698	ribose 5-phosphate isomerase
CWT12_RS03635	COG1045	serine acetyltransferase
CWT12_RS03645	COG1739	Uncharacterized protein family UPF0029
CWT12_RS03670	COG2040	homocysteine
CWT12_RS03685	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWT12_RS03700	COG0740	serine-type endopeptidase activity
CWT12_RS03710	COG1683	Conserved Protein
CWT12_RS03735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWT12_RS03750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWT12_RS03755	COG1388	LysM domain
CWT12_RS03760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWT12_RS03775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWT12_RS03780	COG0066	3-isopropylmalate dehydratase activity
CWT12_RS03785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWT12_RS03795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWT12_RS03805	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWT12_RS03815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWT12_RS03820	COG1461	Dihydroxyacetone kinase
CWT12_RS03840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWT12_RS03855	COG0571	ribonuclease III activity
CWT12_RS03875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CWT12_RS03890	COG1294	oxidase, subunit
CWT12_RS03900	COG1530	ribonuclease E activity
CWT12_RS03905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWT12_RS03910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWT12_RS03915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWT12_RS03925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWT12_RS03935	COG0745	RESPONSE REGULATOR receiver
CWT12_RS03940	COG5002	protein histidine kinase activity
CWT12_RS03955	COG1132	(ABC) transporter
CWT12_RS03965	COG0438	transferase activity, transferring glycosyl groups
CWT12_RS03975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CWT12_RS03980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWT12_RS03990	COG0799	negative regulation of ribosome biogenesis
CWT12_RS03995	COG0406	alpha-ribazole phosphatase activity
CWT12_RS04010	COG1968	undecaprenyl-diphosphatase activity
CWT12_RS04015	COG0483	inositol monophosphate 1-phosphatase activity
CWT12_RS04035	COG0110	maltose O-acetyltransferase activity
CWT12_RS04040	COG1063	alcohol dehydrogenase
CWT12_RS04045	COG1120	ATPase activity
CWT12_RS04050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWT12_RS04055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_RS04060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_RS04085	COG1140	nitrate reductase beta subunit
CWT12_RS04100	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWT12_RS04100	COG0315	cyclic pyranopterin monophosphate synthase activity
CWT12_RS04115	COG0315	cyclic pyranopterin monophosphate synthase activity
CWT12_RS04135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWT12_RS04160	COG1162	GTPase activity
CWT12_RS04165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWT12_RS04170	COG2838	Isocitrate dehydrogenase
CWT12_RS04180	COG1595	DNA-templated transcription, initiation
CWT12_RS04205	COG0741	lytic transglycosylase activity
CWT12_RS04205	COG1196	nuclear chromosome segregation
CWT12_RS04205	COG0739	heme binding
CWT12_RS04210	COG0584	glycerophosphoryl diester phosphodiesterase
CWT12_RS04215	COG2272	Belongs to the type-B carboxylesterase lipase family
CWT12_RS04245	COG0018	arginyl-trna synthetase
CWT12_RS04250	COG0019	diaminopimelate decarboxylase activity
CWT12_RS04275	COG0083	homoserine kinase activity
CWT12_RS04285	COG0254	rRNA binding
CWT12_RS04290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWT12_RS04320	COG0366	Alpha amylase catalytic
CWT12_RS04325	COG1472	Belongs to the glycosyl hydrolase 3 family
CWT12_RS04335	COG0366	Alpha amylase catalytic
CWT12_RS04340	COG1501	Belongs to the glycosyl hydrolase 31 family
CWT12_RS04345	COG1609	Transcriptional regulator
CWT12_RS04355	COG1940	carbohydrate kinase activity
CWT12_RS04355	COG1846	Transcriptional regulator
CWT12_RS04365	COG1175	transmembrane transport
CWT12_RS04385	COG0205	6-phosphofructokinase activity
CWT12_RS04410	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CWT12_RS04415	COG0039	L-malate dehydrogenase activity
CWT12_RS04430	COG0395	ABC-type sugar transport system, permease component
CWT12_RS04480	COG3281	Trehalose synthase
CWT12_RS04485	COG0366	Alpha amylase catalytic
CWT12_RS04505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWT12_RS04510	COG1725	Transcriptional regulator
CWT12_RS04560	COG3480	Lon protease (S16) C-terminal proteolytic domain
CWT12_RS04605	COG0114	fumarate hydratase activity
CWT12_RS04630	COG1174	glycine betaine transport
CWT12_RS04645	COG1609	Transcriptional regulator
CWT12_RS04650	COG0673	inositol 2-dehydrogenase activity
CWT12_RS04660	COG2814	Major facilitator Superfamily
CWT12_RS04670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWT12_RS04700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWT12_RS04710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWT12_RS04715	COG0154	amidase activity
CWT12_RS04720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWT12_RS04750	COG0647	UMP catabolic process
CWT12_RS04760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWT12_RS04890	COG1674	ftsk spoiiie
CWT12_RS04895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWT12_RS04940	COG0569	domain protein
CWT12_RS04945	COG0531	amino acid
CWT12_RS04950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWT12_RS04955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWT12_RS04965	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWT12_RS04970	COG1013	pyruvate-flavodoxin oxidoreductase activity
CWT12_RS04975	COG0493	'glutamate synthase
CWT12_RS04985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWT12_RS04990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CWT12_RS04995	COG1881	PFAM PEBP family protein
CWT12_RS05015	COG1435	thymidine kinase activity
CWT12_RS05045	COG0587	DNA-directed DNA polymerase activity
CWT12_RS05065	COG0546	phosphoglycolate phosphatase activity
CWT12_RS05070	COG0676	glucose-6-phosphate 1-epimerase activity
CWT12_RS05080	COG0738	Major facilitator superfamily
CWT12_RS05100	COG0667	Aldo Keto reductase
CWT12_RS05105	COG0425	Belongs to the sulfur carrier protein TusA family
CWT12_RS05110	COG2391	methyltransferase activity
CWT12_RS05125	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWT12_RS05130	COG1879	ABC-type sugar transport system periplasmic component
CWT12_RS05135	COG0517	IMP dehydrogenase activity
CWT12_RS05135	COG1994	Peptidase M50
CWT12_RS05140	COG2264	protein methyltransferase activity
CWT12_RS05155	COG1222	aaa ATPase
CWT12_RS05160	COG4122	O-methyltransferase activity
CWT12_RS05170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CWT12_RS05180	COG0107	imidazoleglycerol-phosphate synthase activity
CWT12_RS05200	COG0134	indole-3-glycerol-phosphate synthase activity
CWT12_RS05205	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWT12_RS05235	COG0539	negative regulation of cytoplasmic translation
CWT12_RS05245	COG0237	dephospho-CoA kinase activity
CWT12_RS05250	COG0556	nucleotide-excision repair
CWT12_RS05275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWT12_RS05280	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CWT12_RS05285	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CWT12_RS05330	COG0561	phosphatase activity
CWT12_RS05345	COG3711	transcriptional antiterminator
CWT12_RS05350	COG2190	(PTS) system
CWT12_RS05350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_RS05350	COG1263	PTS System
CWT12_RS05360	COG3739	integral membrane protein
CWT12_RS05370	COG1660	Displays ATPase and GTPase activities
CWT12_RS05380	COG1481	regulation of sporulation
CWT12_RS05385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWT12_RS05395	COG0149	triose-phosphate isomerase activity
CWT12_RS05400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWT12_RS05420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWT12_RS05435	COG1160	GTP binding
CWT12_RS05440	COG0519	Catalyzes the synthesis of GMP from XMP
CWT12_RS05445	COG0166	Belongs to the GPI family
CWT12_RS05465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWT12_RS05465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CWT12_RS05500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWT12_RS05520	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CWT12_RS05540	COG4989	oxidoreductase activity
CWT12_RS05560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CWT12_RS05585	COG0667	Aldo Keto reductase
CWT12_RS05610	COG1263	PTS System
CWT12_RS05610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_RS05610	COG2190	(PTS) system
CWT12_RS05625	COG0205	6-phosphofructokinase activity
CWT12_RS05635	COG1216	Glycosyl transferase, family 2
CWT12_RS05650	COG0805	protein transport
CWT12_RS05655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWT12_RS05660	COG2378	regulation of single-species biofilm formation
CWT12_RS05675	COG0140	phosphoribosyl-ATP diphosphatase activity
CWT12_RS05680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWT12_RS05685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWT12_RS05690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWT12_RS05705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWT12_RS05710	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CWT12_RS05710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_RS05710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWT12_RS05715	COG1461	Dihydroxyacetone kinase
CWT12_RS05720	COG2376	Dihydroxyacetone kinase
CWT12_RS05730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWT12_RS05735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWT12_RS05745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWT12_RS05755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWT12_RS05770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWT12_RS05780	COG1758	RNA polymerase activity
CWT12_RS05785	COG0194	GDP metabolic process
CWT12_RS05795	COG0284	orotidine-5'-phosphate decarboxylase activity
CWT12_RS05805	COG0505	Belongs to the CarA family
CWT12_RS05815	COG0540	Belongs to the ATCase OTCase family
CWT12_RS05820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CWT12_RS05825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWT12_RS05830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWT12_RS05840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWT12_RS05855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWT12_RS05865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWT12_RS05875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWT12_RS05885	COG0730	response to heat
CWT12_RS05895	COG2409	Drug exporters of the RND superfamily
CWT12_RS05900	COG0009	L-threonylcarbamoyladenylate synthase
CWT12_RS05910	COG1063	alcohol dehydrogenase
CWT12_RS05930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWT12_RS05960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWT12_RS05980	COG1196	nuclear chromosome segregation
CWT12_RS06030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWT12_RS06035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWT12_RS06040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWT12_RS06045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWT12_RS06055	COG2255	four-way junction helicase activity
CWT12_RS06060	COG0632	four-way junction helicase activity
CWT12_RS06065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CWT12_RS06070	COG0217	transcriptional regulatory protein
CWT12_RS06090	COG0438	transferase activity, transferring glycosyl groups
CWT12_RS06100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CWT12_RS06110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWT12_RS06170	COG1882	Formate acetyltransferase
CWT12_RS06175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWT12_RS06190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWT12_RS06195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWT12_RS06215	COG2815	serine threonine protein kinase
CWT12_RS06215	COG0515	serine threonine protein kinase
CWT12_RS06220	COG0321	lipoyl(octanoyl) transferase activity
CWT12_RS06225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWT12_RS06245	COG0765	amino acid transport
CWT12_RS06275	COG0174	glutamine synthetase
CWT12_RS06280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWT12_RS06290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWT12_RS06290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWT12_RS06315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWT12_RS06330	COG0436	Aminotransferase
CWT12_RS06355	COG1027	Aspartate ammonia-lyase
CWT12_RS06365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWT12_RS06390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CWT12_RS06470	COG0791	NLP P60 protein
CWT12_RS06470	COG1388	LysM domain
CWT12_RS06680	COG0358	DNA primase activity
CWT12_RS06705	COG3833	ABC-type maltose transport systems, permease component
CWT12_RS06715	COG1609	Transcriptional regulator
CWT12_RS06725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWT12_RS06735	COG0667	Aldo Keto reductase
CWT12_RS06740	COG0167	dihydroorotate dehydrogenase activity
CWT12_RS06760	COG0789	Transcriptional regulator
CWT12_RS06765	COG1131	(ABC) transporter
CWT12_RS06775	COG2151	metal-sulfur cluster biosynthetic enzyme
CWT12_RS06780	COG0822	iron-sulfur transferase activity
CWT12_RS06790	COG0396	ATPase activity
CWT12_RS06795	COG0719	Fe-S assembly protein
CWT12_RS06815	COG0395	ABC-type sugar transport system, permease component
CWT12_RS06860	COG0351	phosphomethylpyrimidine kinase
CWT12_RS06870	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CWT12_RS06875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWT12_RS06885	COG2815	serine threonine protein kinase
CWT12_RS06885	COG0515	serine threonine protein kinase
CWT12_RS06890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CWT12_RS06895	COG0205	6-phosphofructokinase activity
CWT12_RS06910	COG2026	Addiction module toxin, RelE StbE family
CWT12_RS06915	COG2161	toxin-antitoxin pair type II binding
CWT12_RS06960	COG0488	(ABC) transporter
CWT12_RS07000	COG1119	ATPase activity
CWT12_RS07010	COG0297	glycogen (starch) synthase activity
CWT12_RS07020	COG0560	Phosphoserine phosphatase
CWT12_RS07050	COG0423	glycine-tRNA ligase activity
CWT12_RS07060	COG1116	anion transmembrane transporter activity
CWT12_RS07065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWT12_RS07075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWT12_RS07080	COG1381	Involved in DNA repair and RecF pathway recombination
CWT12_RS07085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWT12_RS07100	COG1476	TRANSCRIPTIONal
CWT12_RS07105	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWT12_RS07110	COG1131	(ABC) transporter
CWT12_RS07125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWT12_RS07135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWT12_RS07155	COG1309	transcriptional regulator
CWT12_RS07175	COG0484	heat shock protein binding
CWT12_RS07180	COG1420	regulation of RNA biosynthetic process
CWT12_RS07205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWT12_RS07215	COG0481	GTPase activity
CWT12_RS07235	COG1216	Glycosyl transferase, family 2
CWT12_RS07245	COG1472	Belongs to the glycosyl hydrolase 3 family
CWT12_RS07270	COG0133	tryptophan synthase activity
CWT12_RS07280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWT12_RS07285	COG0512	Glutamine amidotransferase of anthranilate synthase
CWT12_RS07300	COG0159	tryptophan synthase activity
CWT12_RS07305	COG2855	membrane
CWT12_RS07330	COG0268	Binds directly to 16S ribosomal RNA
CWT12_RS07335	COG4868	Belongs to the UPF0371 family
CWT12_RS07350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWT12_RS07350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWT12_RS07355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWT12_RS07370	COG1555	photosystem II stabilization
CWT12_RS07380	COG0433	COG0433 Predicted ATPase
CWT12_RS07465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWT12_RS07470	COG2094	Belongs to the DNA glycosylase MPG family
CWT12_RS07475	COG0165	Argininosuccinate lyase
CWT12_RS07485	COG0137	argininosuccinate synthase activity
CWT12_RS07490	COG1438	arginine binding
CWT12_RS07500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWT12_RS07510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWT12_RS07525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWT12_RS07535	COG1131	(ABC) transporter
CWT12_RS07570	COG0765	amino acid transport
CWT12_RS07595	COG2801	Transposase and inactivated derivatives
CWT12_RS07605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWT12_RS07610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWT12_RS07615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWT12_RS07620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CWT12_RS07630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWT12_RS07635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWT12_RS07665	COG2885	chlorophyll binding
CWT12_RS07695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWT12_RS07710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWT12_RS07735	COG2501	S4 domain
CWT12_RS07745	COG0587	DNA-directed DNA polymerase activity
CWT12_RS07760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWT12_RS07765	COG3599	regulation of cell shape
CWT12_RS07780	COG1799	cell septum assembly
CWT12_RS07790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWT12_RS07800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWT12_RS07815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWT12_RS07830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWT12_RS07835	COG0768	penicillin binding
CWT12_RS07845	COG0275	rRNA processing
CWT12_RS07850	COG2001	Belongs to the MraZ family
CWT12_RS07860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWT12_RS07880	COG0318	PFAM AMP-dependent synthetase and ligase
CWT12_RS07885	COG0318	PFAM AMP-dependent synthetase and ligase
CWT12_RS07890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWT12_RS07900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWT12_RS07915	COG0612	Peptidase, M16
CWT12_RS07920	COG1185	polyribonucleotide nucleotidyltransferase activity
CWT12_RS07940	COG0196	riboflavin kinase activity
CWT12_RS07945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWT12_RS07950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWT12_RS07960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWT12_RS07970	COG0195	Participates in both transcription termination and antitermination
CWT12_RS07975	COG0779	Required for maturation of 30S ribosomal subunits
CWT12_RS07995	COG0442	prolyl-tRNA aminoacylation
CWT12_RS08015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWT12_RS08020	COG0750	zinc metalloprotease
CWT12_RS08025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWT12_RS08035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWT12_RS08045	COG0233	cytoplasmic translational termination
CWT12_RS08055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWT12_RS08060	COG0052	Belongs to the universal ribosomal protein uS2 family
CWT12_RS08075	COG1131	(ABC) transporter
CWT12_RS08085	COG2801	Transposase and inactivated derivatives
CWT12_RS08105	COG0792	nuclease activity
CWT12_RS08115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWT12_RS08120	COG0681	Belongs to the peptidase S26 family
CWT12_RS08135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWT12_RS08140	COG1837	Belongs to the UPF0109 family
CWT12_RS08175	COG1196	nuclear chromosome segregation
CWT12_RS08180	COG4152	abc transporter atp-binding protein
CWT12_RS08190	COG0105	UTP biosynthetic process
CWT12_RS08195	COG0285	dihydrofolate synthase activity
CWT12_RS08210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWT12_RS08230	COG0438	transferase activity, transferring glycosyl groups
CWT12_RS08245	COG1215	transferase activity, transferring glycosyl groups
CWT12_RS08260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWT12_RS08265	COG0175	sulfate reduction
CWT12_RS08280	COG1648	precorrin-2 dehydrogenase activity
CWT12_RS08280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWT12_RS08285	COG0730	response to heat
CWT12_RS08295	COG2188	Transcriptional regulator
CWT12_RS08300	COG1263	PTS System
CWT12_RS08300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_RS08300	COG2190	(PTS) system
CWT12_RS08305	COG0366	Alpha amylase catalytic
CWT12_RS08315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWT12_RS08320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWT12_RS08330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CWT12_RS08340	COG0438	transferase activity, transferring glycosyl groups
CWT12_RS08355	COG1086	Polysaccharide biosynthesis protein
CWT12_RS08360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWT12_RS08395	COG1131	(ABC) transporter
CWT12_RS08410	COG1605	Chorismate mutase
CWT12_RS08410	COG0287	Prephenate dehydrogenase
CWT12_RS08420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWT12_RS08425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWT12_RS08465	COG3470	protein probably involved in high-affinity Fe2 transport
CWT12_RS08470	COG0672	)-iron permease
CWT12_RS08480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWT12_RS08490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWT12_RS08495	COG1126	abc transporter atp-binding protein
CWT12_RS08500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWT12_RS08505	COG0765	amino acid transport
CWT12_RS08510	COG0765	amino acid transport
CWT12_RS08515	COG1252	NADH dehydrogenase
CWT12_RS08525	COG2137	regulation of response to DNA damage stimulus
CWT12_RS08530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CWT12_RS08540	COG1396	sequence-specific DNA binding
CWT12_RS08545	COG1058	Belongs to the CinA family
CWT12_RS08545	COG1546	Belongs to the CinA family
CWT12_RS08555	COG1674	ftsk spoiiie
CWT12_RS08565	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWT12_RS08605	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWT12_RS08610	COG1115	amino acid carrier protein
CWT12_RS08615	COG1115	amino acid carrier protein
CWT12_RS08620	COG1115	amino acid carrier protein
CWT12_RS08635	COG3304	Inner membrane component domain
CWT12_RS08675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CWT12_RS08680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWT12_RS08700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWT12_RS08710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CWT12_RS08730	COG0363	glucosamine-6-phosphate deaminase activity
CWT12_RS08750	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CWT12_RS08755	COG1940	carbohydrate kinase activity
CWT12_RS08760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWT12_RS08770	COG0444	Belongs to the ABC transporter superfamily
CWT12_RS08780	COG0747	negative chemotaxis
CWT12_RS08805	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWT12_RS08825	COG0667	Aldo Keto reductase
CWT12_RS08845	COG2884	Cell division ATP-binding protein ftsE
CWT12_RS08870	COG1131	(ABC) transporter
CWT12_RS08870	COG1716	ATPase activity
CWT12_RS08870	COG0842	Transport permease protein
CWT12_RS08885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CWT12_RS08895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWT12_RS08910	COG1086	Polysaccharide biosynthesis protein
CWT12_RS08915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWT12_RS08925	COG0438	transferase activity, transferring glycosyl groups
CWT12_RS08945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWT12_RS08950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWT12_RS08965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWT12_RS08985	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWT12_RS08990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CWT12_RS09000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWT12_RS09005	COG0473	3-isopropylmalate dehydrogenase activity
CWT12_RS09015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWT12_RS09025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWT12_RS09030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWT12_RS09045	COG0569	domain protein
CWT12_RS09045	COG2985	domain, Protein
CWT12_RS09055	COG1468	defense response to virus
CWT12_RS09055	COG1518	maintenance of DNA repeat elements
CWT12_RS09085	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWT12_RS09100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWT12_RS09120	COG0420	3'-5' exonuclease activity
CWT12_RS09125	COG0419	ATPase involved in DNA repair
CWT12_RS09165	COG0653	protein targeting
CWT12_RS09175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWT12_RS09180	COG5401	PFAM Sporulation and spore germination
CWT12_RS09185	COG5002	protein histidine kinase activity
CWT12_RS09185	COG5000	phosphorelay sensor kinase activity
CWT12_RS09190	COG0745	RESPONSE REGULATOR receiver
CWT12_RS09205	COG0714	Associated with various cellular activities
CWT12_RS09255	COG1482	cell wall glycoprotein biosynthetic process
CWT12_RS09275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CWT12_RS09290	COG3754	Rhamnan synthesis protein F
CWT12_RS09460	COG1316	TRANSCRIPTIONal
CWT12_RS09470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWT12_RS09515	COG0424	maF-like protein
CWT12_RS09525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWT12_RS09550	COG0501	Belongs to the peptidase M48B family
CWT12_RS09580	COG1007	ATP synthesis coupled electron transport
CWT12_RS09590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWT12_RS09595	COG0713	ATP synthesis coupled electron transport
CWT12_RS09600	COG0839	Belongs to the complex I subunit 6 family
CWT12_RS09610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CWT12_RS09615	COG1034	ATP synthesis coupled electron transport
CWT12_RS09620	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CWT12_RS09630	COG0649	NAD binding
CWT12_RS09635	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWT12_RS09640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWT12_RS09650	COG0644	oxidoreductase
CWT12_RS09655	COG2226	methyltransferase
CWT12_RS09660	COG1169	isochorismate synthase
CWT12_RS09680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWT12_RS09690	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CWT12_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
CWT12_RS09695	COG3347	Dehydrogenase
CWT12_RS09705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWT12_RS09710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWT12_RS09715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWT12_RS09720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWT12_RS09735	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWT12_RS09740	COG0356	it plays a direct role in the translocation of protons across the membrane
CWT12_RS09750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWT12_RS09765	COG2197	response regulator
CWT12_RS09795	COG0577	efflux transmembrane transporter activity
CWT12_RS09795	COG1136	(ABC) transporter
CWT12_RS09810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWT12_RS09845	COG0583	DNA-binding transcription factor activity
CWT12_RS09855	COG0656	L-ascorbic acid biosynthetic process
CWT12_RS09870	COG1028	Short-chain dehydrogenase reductase Sdr
CWT12_RS09885	COG1131	(ABC) transporter
CWT12_RS09915	COG1129	ABC transporter
CWT12_RS09920	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWT12_RS09935	COG0667	Aldo Keto reductase
CWT12_RS09965	COG1309	transcriptional regulator
CWT12_RS09975	COG3177	Filamentation induced by cAMP protein fic
CWT12_RS09980	COG0519	Catalyzes the synthesis of GMP from XMP
CWT12_RS10015	COG0673	inositol 2-dehydrogenase activity
CWT12_RS10030	COG1063	alcohol dehydrogenase
CWT12_RS10040	COG2814	Major facilitator Superfamily
CWT12_RS10045	COG2814	Major facilitator Superfamily
CWT12_RS10050	COG1082	Xylose isomerase domain protein TIM barrel
CWT12_RS10055	COG0673	inositol 2-dehydrogenase activity
CWT12_RS10070	COG3962	Belongs to the TPP enzyme family
CWT12_RS10075	COG3718	enzyme involved in inositol metabolism
CWT12_RS10095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWT12_RS10100	COG0673	inositol 2-dehydrogenase activity
CWT12_RS10125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWT12_RS10130	COG0328	RNA-DNA hybrid ribonuclease activity
CWT12_RS10135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_RS10145	COG0395	ABC-type sugar transport system, permease component
CWT12_RS10160	COG0516	GMP reductase activity
CWT12_RS10175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWT12_RS10180	COG2949	membrane
CWT12_RS10190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CWT12_RS10195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWT12_RS10205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWT12_RS10225	COG1214	PFAM Peptidase M22, glycoprotease
CWT12_RS10225	COG0456	acetyltransferase
CWT12_RS10230	COG0802	atpase or kinase
CWT12_RS10235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWT12_RS10255	COG4585	Histidine kinase
CWT12_RS10260	COG2197	response regulator
CWT12_RS10270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWT12_RS10275	COG1072	(Pantothenic acid kinase))
CWT12_RS10290	COG1733	regulation of RNA biosynthetic process
CWT12_RS10295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CWT12_RS10300	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CWT12_RS10325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWT12_RS10330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWT12_RS10335	COG0101	tRNA pseudouridine synthase activity
CWT12_RS10340	COG1940	carbohydrate kinase activity
CWT12_RS10345	COG0203	ribosomal protein L17
CWT12_RS10350	COG0202	RNA polymerase activity
CWT12_RS10360	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWT12_RS10365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWT12_RS10370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWT12_RS10380	COG0563	adenylate kinase activity
CWT12_RS10390	COG0200	Binds to the 23S rRNA
CWT12_RS10400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWT12_RS10405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWT12_RS10410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWT12_RS10415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWT12_RS10420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWT12_RS10425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWT12_RS10430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWT12_RS10435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWT12_RS10445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWT12_RS10450	COG0255	Belongs to the universal ribosomal protein uL29 family
CWT12_RS10455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWT12_RS10460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWT12_RS10465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWT12_RS10475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWT12_RS10480	COG0089	rRNA binding
CWT12_RS10485	COG0088	Forms part of the polypeptide exit tunnel
CWT12_RS10490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWT12_RS10495	COG0051	transcription antitermination factor activity, RNA binding
CWT12_RS10500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWT12_RS10505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWT12_RS10510	COG0049	tRNA binding
CWT12_RS10515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWT12_RS10535	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWT12_RS10545	COG1100	Small GTP-binding protein
CWT12_RS10610	COG0085	RNA polymerase activity
CWT12_RS10620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWT12_RS10625	COG2885	chlorophyll binding
CWT12_RS10640	COG0515	serine threonine protein kinase
CWT12_RS10645	COG0081	regulation of translation
CWT12_RS10650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWT12_RS10655	COG0250	Participates in transcription elongation, termination and antitermination
CWT12_RS10670	COG0436	Aminotransferase
CWT12_RS10695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CWT12_RS10700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWT12_RS10720	COG0395	ABC-type sugar transport system, permease component
CWT12_RS10725	COG3507	Belongs to the glycosyl hydrolase 43 family
CWT12_RS10750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWT12_RS10785	COG0395	ABC-type sugar transport system, permease component
CWT12_RS10790	COG1175	transmembrane transport
CWT12_RS10800	COG3458	cephalosporin-C deacetylase activity
CWT12_RS10810	COG4214	carbohydrate transport
CWT12_RS10820	COG4213	ABC transporter substrate-binding protein
CWT12_RS10825	COG1609	Transcriptional regulator
CWT12_RS10830	COG2017	converts alpha-aldose to the beta-anomer
CWT12_RS10840	COG1609	Transcriptional regulator
CWT12_RS10845	COG1609	Transcriptional regulator
CWT12_RS10855	COG2160	L-arabinose isomerase activity
CWT12_RS10880	COG2211	Major facilitator Superfamily
CWT12_RS10890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWT12_RS10900	COG1733	regulation of RNA biosynthetic process
CWT12_RS10920	COG0395	ABC-type sugar transport system, permease component
CWT12_RS10930	COG1609	Transcriptional regulator
CWT12_RS10935	COG4214	carbohydrate transport
CWT12_RS10980	COG1070	Carbohydrate kinase
CWT12_RS10985	COG2115	Belongs to the xylose isomerase family
CWT12_RS10990	COG1940	carbohydrate kinase activity
CWT12_RS10990	COG1846	Transcriptional regulator
CWT12_RS11005	COG0667	Aldo Keto reductase
CWT12_RS11010	COG2376	Dihydroxyacetone kinase
CWT12_RS11015	COG2376	Dihydroxyacetone kinase
CWT12_RS11025	COG3775	system Galactitol-specific IIC component
CWT12_RS11100	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CWT12_RS11110	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CWT12_RS11120	COG0247	lactate metabolic process
CWT12_RS11135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWT12_RS11140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWT12_RS11145	COG1620	l-lactate permease
CWT12_RS11155	COG0247	lactate metabolic process
CWT12_RS11160	COG1139	Iron-sulfur cluster binding protein
CWT12_RS11165	COG1556	Lactate utilization protein
CWT12_RS11190	COG3414	Phosphotransferase system galactitol-specific IIB component
CWT12_RS11235	COG1136	(ABC) transporter
CWT12_RS11260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CWT12_RS11275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWT12_RS11290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWT12_RS11295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWT12_RS11300	COG0302	gtp cyclohydrolase
CWT12_RS11305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWT12_RS11375	COG1518	maintenance of DNA repeat elements
CWT12_RS11410	COG2027	D-alanyl-D-alanine carboxypeptidase
CWT12_RS11415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CWT12_RS11420	COG3883	PFAM NLP P60 protein
CWT12_RS11420	COG0791	NLP P60 protein
CWT12_RS11425	COG2873	o-acetylhomoserine
CWT12_RS11430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWT12_RS11450	COG0714	Associated with various cellular activities
CWT12_RS11475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWT12_RS11475	COG0574	Belongs to the PEP-utilizing enzyme family
CWT12_RS11510	COG1490	D-aminoacyl-tRNA deacylase activity
CWT12_RS11520	COG0738	Major facilitator superfamily
CWT12_RS11545	COG3485	protocatechuate 3,4-dioxygenase
CWT12_RS11555	COG0745	RESPONSE REGULATOR receiver
CWT12_RS11560	COG2814	Major facilitator Superfamily
CWT12_RS11570	COG0463	Glycosyl transferase, family 2
CWT12_RS11580	COG1136	(ABC) transporter
CWT12_RS11580	COG0577	efflux transmembrane transporter activity
CWT12_RS11675	COG4691	Plasmid stability protein
CWT12_RS11785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CWT12_RS11795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWT12_RS11840	COG0191	fructose-bisphosphate aldolase activity
CWT12_RS11865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CWT12_RS11900	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CWT12_RS11910	COG4221	oxidoreductase activity
CWT12_RS11925	COG0778	Nitroreductase
CWT12_RS11930	COG2176	DNA-directed DNA polymerase activity
CWT12_RS11955	COG0717	Belongs to the dCTP deaminase family
CWT12_RS11975	COG0494	nUDIX hydrolase
CWT12_RS12035	COG0631	protein serine/threonine phosphatase activity
CWT12_RS12050	COG5650	phosphatidylinositol metabolic process
CWT12_RS12070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWT12_RS12075	COG1132	(ABC) transporter
CWT12_RS12080	COG4988	ABC transporter
CWT12_RS12090	COG0745	RESPONSE REGULATOR receiver
CWT12_RS12095	COG2205	protein histidine kinase activity
CWT12_RS12105	COG0577	efflux transmembrane transporter activity
CWT12_RS12105	COG1136	(ABC) transporter
CWT12_RS12110	COG0577	efflux transmembrane transporter activity
CWT12_RS12110	COG1136	(ABC) transporter
CWT12_RS12165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWT12_RS12475	COG3617	BRO family, N-terminal domain
CWT12_RS12510	COG3842	ATPase activity
CWT12_RS12540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWT12_RS12545	COG0215	cysteine-tRNA ligase activity
CWT12_RS12550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWT12_RS12555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWT12_RS12570	COG0546	phosphoglycolate phosphatase activity
CWT12_RS12590	COG3059	membrane
CWT12_RS12600	COG3715	PTS system
CWT12_RS12620	COG1621	beta-fructofuranosidase activity
CWT12_RS12620	COG1621	beta-fructofuranosidase activity
CWT12_RS12665	COG1505	serine-type exopeptidase activity
CWT12_RS12680	COG0789	Transcriptional regulator
CWT12_RS12685	COG0484	heat shock protein binding
CWT12_RS12690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWT12_RS12695	COG0443	Heat shock 70 kDa protein
CWT12_RS12700	COG0667	Aldo Keto reductase
CWT12_RS12705	COG0596	Alpha beta hydrolase
CWT12_RS12730	COG1597	lipid kinase activity
CWT12_RS12780	COG1136	(ABC) transporter
CWT12_RS12780	COG0577	efflux transmembrane transporter activity
CWT12_RS12800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWT12_RS12805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWT12_RS12815	COG0181	hydroxymethylbilane synthase activity
CWT12_RS12825	COG0113	porphobilinogen synthase activity
CWT12_RS12830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWT12_RS12845	COG0783	Belongs to the Dps family
CWT12_RS12850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWT12_RS12860	COG1309	transcriptional regulator
CWT12_RS12870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWT12_RS12930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWT12_RS13000	COG2233	PERMEase
CWT12_RS13030	COG1733	regulation of RNA biosynthetic process
CWT12_RS13040	COG0351	phosphomethylpyrimidine kinase
CWT12_RS13045	COG0305	Participates in initiation and elongation during chromosome replication
CWT12_RS13050	COG0534	Mate efflux family protein
CWT12_RS13055	COG0359	binds to the 23S rRNA
CWT12_RS13060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWT12_RS13070	COG0360	Binds together with S18 to 16S ribosomal RNA
CWT12_RS13075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWT12_RS13080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWT12_RS13095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWT12_RS13105	COG2211	Major facilitator Superfamily
CWT12_RS13125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWT12_RS13130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CWT12_RS13200	COG3118	belongs to the thioredoxin family
CWT12_RS13205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWT12_RS13210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWT12_RS13215	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWT12_RS13225	COG1192	Involved in chromosome partitioning
CWT12_RS13230	COG0357	Ribosomal RNA small subunit methyltransferase G
CWT12_RS13240	COG0706	membrane insertase activity
CWT12_RS13245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWT12_RS13250	COG0594	ribonuclease P activity
CWT12_RS13255	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWT12_RS13260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWT12_RS13265	COG0592	DNA-directed DNA polymerase activity
CWT12_RS13270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP