locus-tag	class	description
MANAM107_RS00020	COG0667	Aldo Keto reductase
MANAM107_RS00025	COG2807	transmembrane transport
MANAM107_RS00030	COG0167	dihydroorotate dehydrogenase activity
MANAM107_RS00060	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MANAM107_RS00070	COG2151	metal-sulfur cluster biosynthetic enzyme
MANAM107_RS00075	COG0822	iron-sulfur transferase activity
MANAM107_RS00085	COG0396	ATPase activity
MANAM107_RS00095	COG0719	Fe-S assembly protein
MANAM107_RS00110	COG0395	ABC-type sugar transport system, permease component
MANAM107_RS00125	COG1609	Transcriptional regulator
MANAM107_RS00160	COG0497	DNA recombination
MANAM107_RS00165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MANAM107_RS00180	COG0647	UMP catabolic process
MANAM107_RS00205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MANAM107_RS00230	COG2094	Belongs to the DNA glycosylase MPG family
MANAM107_RS00235	COG0165	Argininosuccinate lyase
MANAM107_RS00245	COG0137	argininosuccinate synthase activity
MANAM107_RS00250	COG1438	arginine binding
MANAM107_RS00255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MANAM107_RS00260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MANAM107_RS00270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MANAM107_RS00285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MANAM107_RS00290	COG0765	amino acid transport
MANAM107_RS00295	COG0765	amino acid transport
MANAM107_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MANAM107_RS00305	COG1126	abc transporter atp-binding protein
MANAM107_RS00345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MANAM107_RS00350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MANAM107_RS00355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MANAM107_RS00360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MANAM107_RS00370	COG4133	protoheme IX ABC transporter activity
MANAM107_RS00385	COG0575	Belongs to the CDS family
MANAM107_RS00395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MANAM107_RS00400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MANAM107_RS00415	COG0131	Imidazoleglycerol-phosphate dehydratase
MANAM107_RS00420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MANAM107_RS00430	COG0514	ATP-dependent DNA helicase (RecQ)
MANAM107_RS00450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MANAM107_RS00460	COG0463	Glycosyl transferase, family 2
MANAM107_RS00470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MANAM107_RS00480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MANAM107_RS00505	COG2501	S4 domain
MANAM107_RS00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MANAM107_RS00515	COG0587	DNA-directed DNA polymerase activity
MANAM107_RS00530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MANAM107_RS00535	COG3599	regulation of cell shape
MANAM107_RS00545	COG1799	cell septum assembly
MANAM107_RS00550	COG1496	oxidoreductase activity
MANAM107_RS00565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MANAM107_RS00580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MANAM107_RS00585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MANAM107_RS00590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MANAM107_RS00595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MANAM107_RS00600	COG0768	penicillin binding
MANAM107_RS00610	COG0275	rRNA processing
MANAM107_RS00615	COG2001	Belongs to the MraZ family
MANAM107_RS00625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MANAM107_RS00645	COG0318	PFAM AMP-dependent synthetase and ligase
MANAM107_RS00660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MANAM107_RS00665	COG0657	acetylesterase activity
MANAM107_RS00680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MANAM107_RS00685	COG0612	Peptidase, M16
MANAM107_RS00695	COG1185	polyribonucleotide nucleotidyltransferase activity
MANAM107_RS00715	COG2814	Major facilitator Superfamily
MANAM107_RS00725	COG0577	efflux transmembrane transporter activity
MANAM107_RS00725	COG1136	(ABC) transporter
MANAM107_RS00735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MANAM107_RS00740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MANAM107_RS00750	COG0697	spore germination
MANAM107_RS00755	COG0583	DNA-binding transcription factor activity
MANAM107_RS00775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MANAM107_RS00800	COG0442	prolyl-tRNA aminoacylation
MANAM107_RS00815	COG2197	response regulator
MANAM107_RS00850	COG3415	Transposase
MANAM107_RS00850	COG2801	Transposase and inactivated derivatives
MANAM107_RS00860	COG0456	acetyltransferase
MANAM107_RS00865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MANAM107_RS00875	COG0750	zinc metalloprotease
MANAM107_RS00880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MANAM107_RS00890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MANAM107_RS00900	COG0233	cytoplasmic translational termination
MANAM107_RS00910	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MANAM107_RS00915	COG0052	Belongs to the universal ribosomal protein uS2 family
MANAM107_RS00940	COG4974	Belongs to the 'phage' integrase family
MANAM107_RS00955	COG0792	nuclease activity
MANAM107_RS00965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MANAM107_RS00970	COG0681	Belongs to the peptidase S26 family
MANAM107_RS00980	COG0681	Belongs to the peptidase S26 family
MANAM107_RS00990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MANAM107_RS00995	COG1837	Belongs to the UPF0109 family
MANAM107_RS01000	COG0228	four-way junction DNA binding
MANAM107_RS01010	COG1131	(ABC) transporter
MANAM107_RS01020	COG4585	Histidine kinase
MANAM107_RS01025	COG2197	response regulator
MANAM107_RS01075	COG0352	thiamine-phosphate diphosphorylase activity
MANAM107_RS01080	COG0477	Major facilitator Superfamily
MANAM107_RS01085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MANAM107_RS01085	COG0352	thiamine-phosphate diphosphorylase activity
MANAM107_RS01085	COG0351	phosphomethylpyrimidine kinase
MANAM107_RS01100	COG1196	nuclear chromosome segregation
MANAM107_RS01105	COG0105	UTP biosynthetic process
MANAM107_RS01110	COG2188	Transcriptional regulator
MANAM107_RS01115	COG2190	(PTS) system
MANAM107_RS01115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_RS01115	COG1263	PTS System
MANAM107_RS01120	COG0366	Alpha amylase catalytic
MANAM107_RS01125	COG0285	dihydrofolate synthase activity
MANAM107_RS01130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MANAM107_RS01165	COG2056	Na+-H+ antiporter family
MANAM107_RS01170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MANAM107_RS01180	COG1122	ATPase activity
MANAM107_RS01190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MANAM107_RS01205	COG1222	aaa ATPase
MANAM107_RS01220	COG0366	Alpha amylase catalytic
MANAM107_RS01235	COG1653	transport
MANAM107_RS01250	COG1605	Chorismate mutase
MANAM107_RS01250	COG0287	Prephenate dehydrogenase
MANAM107_RS01255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MANAM107_RS01260	COG0740	serine-type endopeptidase activity
MANAM107_RS01285	COG0544	peptidyl-prolyl cis-trans isomerase activity
MANAM107_RS01315	COG1739	Uncharacterized protein family UPF0029
MANAM107_RS01325	COG1045	serine acetyltransferase
MANAM107_RS01345	COG3590	peptidase
MANAM107_RS01365	COG1263	PTS System
MANAM107_RS01365	COG2190	(PTS) system
MANAM107_RS01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_RS01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_RS01380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MANAM107_RS01410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MANAM107_RS01495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MANAM107_RS01495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_RS01520	COG1615	UPF0182 protein
MANAM107_RS01560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MANAM107_RS01570	COG0738	Major facilitator superfamily
MANAM107_RS01575	COG2390	Transcriptional regulator
MANAM107_RS01585	COG0482	sulfurtransferase activity
MANAM107_RS01595	COG1131	(ABC) transporter
MANAM107_RS01600	COG1725	Transcriptional regulator
MANAM107_RS01615	COG3552	Protein containing von Willebrand factor type A (VWA) domain
MANAM107_RS01620	COG0714	Associated with various cellular activities
MANAM107_RS01635	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MANAM107_RS01645	COG2086	electron transfer activity
MANAM107_RS01665	COG0366	Alpha amylase catalytic
MANAM107_RS01675	COG3281	Trehalose synthase
MANAM107_RS01680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MANAM107_RS01685	COG0058	SHG alpha-glucan phosphorylase activity
MANAM107_RS01725	COG0395	ABC-type sugar transport system, permease component
MANAM107_RS01730	COG1175	transmembrane transport
MANAM107_RS01735	COG1653	transport
MANAM107_RS01740	COG0039	L-malate dehydrogenase activity
MANAM107_RS01745	COG4988	ABC transporter
MANAM107_RS01750	COG1132	(ABC) transporter
MANAM107_RS01755	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MANAM107_RS01770	COG1136	(ABC) transporter
MANAM107_RS01795	COG0045	succinate-CoA ligase (ADP-forming) activity
MANAM107_RS01835	COG0366	Alpha amylase catalytic
MANAM107_RS01840	COG1501	Belongs to the glycosyl hydrolase 31 family
MANAM107_RS01845	COG3291	Pkd domain containing protein
MANAM107_RS01845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MANAM107_RS01865	COG1733	regulation of RNA biosynthetic process
MANAM107_RS01885	COG2910	NAD(P)H-binding
MANAM107_RS01890	COG1733	regulation of RNA biosynthetic process
MANAM107_RS01915	COG0542	response to heat
MANAM107_RS01930	COG2267	carboxylic ester hydrolase activity
MANAM107_RS01985	COG2890	protein-(glutamine-N5) methyltransferase activity
MANAM107_RS01990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MANAM107_RS01995	COG0254	rRNA binding
MANAM107_RS02005	COG0431	NADPH-dependent FMN reductase
MANAM107_RS02015	COG0083	homoserine kinase activity
MANAM107_RS02020	COG0460	homoserine dehydrogenase
MANAM107_RS02030	COG0019	diaminopimelate decarboxylase activity
MANAM107_RS02035	COG0018	arginyl-trna synthetase
MANAM107_RS02045	COG4604	ABC transporter, ATP-binding protein
MANAM107_RS02050	COG4605	iron ion homeostasis
MANAM107_RS02055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_RS02060	COG4607	ABC-type enterochelin transport system periplasmic component
MANAM107_RS02075	COG0739	heme binding
MANAM107_RS02085	COG1253	flavin adenine dinucleotide binding
MANAM107_RS02090	COG0567	Dehydrogenase, E1 component
MANAM107_RS02090	COG0508	dehydrogenase complex catalyzes the overall conversion of
MANAM107_RS02105	COG1309	transcriptional regulator
MANAM107_RS02110	COG1131	(ABC) transporter
MANAM107_RS02115	COG3559	Exporter of polyketide antibiotics
MANAM107_RS02120	COG5662	AntiSigma factor
MANAM107_RS02125	COG1595	DNA-templated transcription, initiation
MANAM107_RS02135	COG2838	Isocitrate dehydrogenase
MANAM107_RS02140	COG1105	Belongs to the carbohydrate kinase PfkB family
MANAM107_RS02145	COG0191	fructose-bisphosphate aldolase activity
MANAM107_RS02150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MANAM107_RS02155	COG1162	GTPase activity
MANAM107_RS02180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MANAM107_RS02210	COG0315	cyclic pyranopterin monophosphate synthase activity
MANAM107_RS02210	COG0521	Mo-molybdopterin cofactor biosynthetic process
MANAM107_RS02225	COG1140	nitrate reductase beta subunit
MANAM107_RS02250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MANAM107_RS02255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_RS02260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_RS02270	COG1120	ATPase activity
MANAM107_RS02275	COG1063	alcohol dehydrogenase
MANAM107_RS02295	COG2249	NAD(P)H dehydrogenase (quinone) activity
MANAM107_RS02320	COG1132	(ABC) transporter
MANAM107_RS02325	COG2375	cellular response to nickel ion
MANAM107_RS02325	COG1132	(ABC) transporter
MANAM107_RS02330	COG0483	inositol monophosphate 1-phosphatase activity
MANAM107_RS02335	COG1968	undecaprenyl-diphosphatase activity
MANAM107_RS02345	COG0420	3'-5' exonuclease activity
MANAM107_RS02350	COG0419	ATPase involved in DNA repair
MANAM107_RS02390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_RS02400	COG0653	protein targeting
MANAM107_RS02410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MANAM107_RS02415	COG0823	Involved in the tonB-independent uptake of proteins
MANAM107_RS02420	COG5002	protein histidine kinase activity
MANAM107_RS02420	COG5000	phosphorelay sensor kinase activity
MANAM107_RS02425	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS02445	COG0714	Associated with various cellular activities
MANAM107_RS02450	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MANAM107_RS02465	COG2835	tetraacyldisaccharide 4'-kinase activity
MANAM107_RS02500	COG1482	cell wall glycoprotein biosynthetic process
MANAM107_RS02510	COG3475	LICD family
MANAM107_RS02520	COG1216	Glycosyl transferase, family 2
MANAM107_RS02525	COG3475	LICD family
MANAM107_RS02530	COG1216	Glycosyl transferase, family 2
MANAM107_RS02545	COG0697	spore germination
MANAM107_RS02555	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS02650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MANAM107_RS02705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MANAM107_RS02725	COG1316	TRANSCRIPTIONal
MANAM107_RS02765	COG0586	Pfam SNARE associated Golgi protein
MANAM107_RS02775	COG5002	protein histidine kinase activity
MANAM107_RS02780	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS02795	COG0424	maF-like protein
MANAM107_RS02830	COG1666	GTP binding
MANAM107_RS02855	COG0501	Belongs to the peptidase M48B family
MANAM107_RS02860	COG0686	Belongs to the AlaDH PNT family
MANAM107_RS02890	COG0142	geranyltranstransferase activity
MANAM107_RS02895	COG1007	ATP synthesis coupled electron transport
MANAM107_RS02905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MANAM107_RS02910	COG0713	ATP synthesis coupled electron transport
MANAM107_RS02925	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MANAM107_RS02930	COG1034	ATP synthesis coupled electron transport
MANAM107_RS02935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MANAM107_RS02945	COG0649	NAD binding
MANAM107_RS02950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MANAM107_RS02955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MANAM107_RS02965	COG0644	oxidoreductase
MANAM107_RS03025	COG2226	methyltransferase
MANAM107_RS03035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MANAM107_RS03040	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MANAM107_RS03045	COG4948	Mandelate Racemase Muconate Lactonizing
MANAM107_RS03050	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MANAM107_RS03060	COG1595	DNA-templated transcription, initiation
MANAM107_RS03075	COG3477	response to acidic pH
MANAM107_RS03100	COG0406	alpha-ribazole phosphatase activity
MANAM107_RS03105	COG2171	N-acyltransferase activity
MANAM107_RS03115	COG1053	succinate dehydrogenase
MANAM107_RS03165	COG1217	gtp-binding protein TYPA
MANAM107_RS03195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANAM107_RS03205	COG2267	carboxylic ester hydrolase activity
MANAM107_RS03220	COG4667	esterase of the alpha-beta hydrolase superfamily
MANAM107_RS03225	COG1902	pentaerythritol trinitrate reductase activity
MANAM107_RS03230	COG3012	SEC-C Motif Domain Protein
MANAM107_RS03235	COG1362	aminopeptidase activity
MANAM107_RS03270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANAM107_RS03295	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_RS03295	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_RS03300	COG3415	Transposase
MANAM107_RS03300	COG2801	Transposase and inactivated derivatives
MANAM107_RS03305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MANAM107_RS03330	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
MANAM107_RS03340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MANAM107_RS03395	COG0210	DNA helicase
MANAM107_RS03405	COG0228	four-way junction DNA binding
MANAM107_RS03420	COG3328	transposase activity
MANAM107_RS03430	COG2801	Transposase and inactivated derivatives
MANAM107_RS03450	COG0012	GTP binding
MANAM107_RS03455	COG1322	Protein conserved in bacteria
MANAM107_RS03460	COG1302	Protein conserved in bacteria
MANAM107_RS03485	COG1595	DNA-templated transcription, initiation
MANAM107_RS03500	COG0833	amino acid
MANAM107_RS03505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MANAM107_RS03510	COG1570	exodeoxyribonuclease VII activity
MANAM107_RS03515	COG1722	exodeoxyribonuclease VII activity
MANAM107_RS03525	COG2249	NAD(P)H dehydrogenase (quinone) activity
MANAM107_RS03540	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
MANAM107_RS03550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MANAM107_RS03560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MANAM107_RS03565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MANAM107_RS03580	COG0583	DNA-binding transcription factor activity
MANAM107_RS03590	COG0431	NADPH-dependent FMN reductase
MANAM107_RS03595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MANAM107_RS03610	COG4171	peptide transport system, permease
MANAM107_RS03620	COG1124	(ABC) transporter
MANAM107_RS03630	COG0129	dihydroxy-acid dehydratase activity
MANAM107_RS03675	COG2197	response regulator
MANAM107_RS03680	COG0193	aminoacyl-tRNA hydrolase activity
MANAM107_RS03685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MANAM107_RS03690	COG0710	3-dehydroquinate dehydratase activity
MANAM107_RS03710	COG2205	protein histidine kinase activity
MANAM107_RS03715	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS03730	COG0577	efflux transmembrane transporter activity
MANAM107_RS03730	COG1136	(ABC) transporter
MANAM107_RS03735	COG0577	efflux transmembrane transporter activity
MANAM107_RS03740	COG0148	phosphopyruvate hydratase activity
MANAM107_RS03750	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS03795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MANAM107_RS03810	COG1309	transcriptional regulator
MANAM107_RS03865	COG0297	glycogen (starch) synthase activity
MANAM107_RS03880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MANAM107_RS03885	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MANAM107_RS03885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_RS03895	COG0714	Associated with various cellular activities
MANAM107_RS03935	COG0488	(ABC) transporter
MANAM107_RS03940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MANAM107_RS03945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MANAM107_RS03965	COG0084	hydrolase, TatD family'
MANAM107_RS03970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MANAM107_RS03980	COG1335	isochorismatase
MANAM107_RS04025	COG1297	OPT oligopeptide transporter protein
MANAM107_RS04035	COG1733	regulation of RNA biosynthetic process
MANAM107_RS04080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MANAM107_RS04090	COG1970	mechanosensitive ion channel activity
MANAM107_RS04115	COG0791	NLP P60 protein
MANAM107_RS04115	COG1388	LysM domain
MANAM107_RS04115	COG3103	Sh3 type 3 domain protein
MANAM107_RS04130	COG2252	PERMEase
MANAM107_RS04165	COG1842	Phage shock protein A
MANAM107_RS04175	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS04180	COG2205	protein histidine kinase activity
MANAM107_RS04195	COG0459	protein refolding
MANAM107_RS04205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MANAM107_RS04215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MANAM107_RS04220	COG0346	lactoylglutathione lyase activity
MANAM107_RS04225	COG0215	cysteine-tRNA ligase activity
MANAM107_RS04255	COG3842	ATPase activity
MANAM107_RS04320	COG2197	response regulator
MANAM107_RS04330	COG1609	Transcriptional regulator
MANAM107_RS04355	COG0542	response to heat
MANAM107_RS04370	COG1505	serine-type exopeptidase activity
MANAM107_RS04400	COG0789	Transcriptional regulator
MANAM107_RS04405	COG0484	heat shock protein binding
MANAM107_RS04410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MANAM107_RS04415	COG0443	Heat shock 70 kDa protein
MANAM107_RS04435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MANAM107_RS04440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_RS04450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MANAM107_RS04485	COG2197	response regulator
MANAM107_RS04500	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
MANAM107_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
MANAM107_RS04550	COG1597	lipid kinase activity
MANAM107_RS04565	COG0803	Belongs to the bacterial solute-binding protein 9 family
MANAM107_RS04570	COG1121	(ABC) transporter
MANAM107_RS04575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_RS04580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_RS04585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MANAM107_RS04585	COG1918	ferrous iron import across plasma membrane
MANAM107_RS04610	COG3226	Transcriptional regulator
MANAM107_RS04620	COG0366	Alpha amylase catalytic
MANAM107_RS04630	COG0783	Belongs to the Dps family
MANAM107_RS04640	COG1131	(ABC) transporter
MANAM107_RS04645	COG1309	transcriptional regulator
MANAM107_RS04670	COG4585	Histidine kinase
MANAM107_RS04675	COG2197	response regulator
MANAM107_RS04710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MANAM107_RS04715	COG0626	cystathionine gamma-synthase activity
MANAM107_RS04720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MANAM107_RS04745	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS04750	COG1840	ABC-type Fe3 transport system, periplasmic component
MANAM107_RS04760	COG3842	ATPase activity
MANAM107_RS04785	COG1653	transport
MANAM107_RS04790	COG0561	phosphatase activity
MANAM107_RS04795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MANAM107_RS04830	COG1597	lipid kinase activity
MANAM107_RS04840	COG0077	Prephenate dehydratase
MANAM107_RS04865	COG1228	amidohydrolase
MANAM107_RS04890	COG1486	melibiose metabolic process
MANAM107_RS04895	COG1349	DNA-binding transcription factor activity
MANAM107_RS04900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MANAM107_RS04900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_RS04910	COG1175	transmembrane transport
MANAM107_RS04915	COG0395	ABC-type sugar transport system, permease component
MANAM107_RS04925	COG2249	NAD(P)H dehydrogenase (quinone) activity
MANAM107_RS04935	COG0535	radical SAM domain protein
MANAM107_RS04945	COG3415	Transposase
MANAM107_RS04945	COG2801	Transposase and inactivated derivatives
MANAM107_RS04950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MANAM107_RS04995	COG2376	Dihydroxyacetone kinase
MANAM107_RS05000	COG1063	alcohol dehydrogenase
MANAM107_RS05010	COG1760	l-serine dehydratase
MANAM107_RS05035	COG0351	phosphomethylpyrimidine kinase
MANAM107_RS05045	COG1121	(ABC) transporter
MANAM107_RS05055	COG1834	amidinotransferase
MANAM107_RS05060	COG0833	amino acid
MANAM107_RS05065	COG0305	Participates in initiation and elongation during chromosome replication
MANAM107_RS05085	COG0359	binds to the 23S rRNA
MANAM107_RS05090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MANAM107_RS05100	COG0360	Binds together with S18 to 16S ribosomal RNA
MANAM107_RS05105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MANAM107_RS05110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MANAM107_RS05120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MANAM107_RS05135	COG1910	domain protein
MANAM107_RS05155	COG2375	cellular response to nickel ion
MANAM107_RS05155	COG1132	(ABC) transporter
MANAM107_RS05160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MANAM107_RS05165	COG1609	Transcriptional regulator
MANAM107_RS05180	COG1175	transmembrane transport
MANAM107_RS05185	COG0395	ABC-type sugar transport system, permease component
MANAM107_RS05230	COG2197	response regulator
MANAM107_RS05240	COG1937	Protein conserved in bacteria
MANAM107_RS05255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MANAM107_RS05260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MANAM107_RS05305	COG1063	alcohol dehydrogenase
MANAM107_RS05320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MANAM107_RS05325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MANAM107_RS05330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_RS05330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MANAM107_RS05345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_RS05350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_RS05355	COG1120	ATPase activity
MANAM107_RS05365	COG0628	permease
MANAM107_RS05375	COG1854	S-ribosylhomocysteine lyase activity
MANAM107_RS05390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_RS05400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MANAM107_RS05415	COG2855	membrane
MANAM107_RS05420	COG0583	DNA-binding transcription factor activity
MANAM107_RS05430	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MANAM107_RS05440	COG1966	Carbon starvation protein
MANAM107_RS05455	COG1716	ATPase activity
MANAM107_RS05460	COG1716	ATPase activity
MANAM107_RS05475	COG0768	penicillin binding
MANAM107_RS05480	COG0515	serine threonine protein kinase
MANAM107_RS05495	COG3764	Sortase (surface protein transpeptidase)
MANAM107_RS05570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MANAM107_RS05575	COG0187	DNA topoisomerase II activity
MANAM107_RS05580	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MANAM107_RS05585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_RS05590	COG0592	DNA-directed DNA polymerase activity
MANAM107_RS05595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MANAM107_RS05600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MANAM107_RS05605	COG0594	ribonuclease P activity
MANAM107_RS05610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MANAM107_RS05615	COG0706	membrane insertase activity
MANAM107_RS05625	COG0357	Ribosomal RNA small subunit methyltransferase G
MANAM107_RS05630	COG1192	Involved in chromosome partitioning
MANAM107_RS05655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MANAM107_RS05665	COG3118	belongs to the thioredoxin family
MANAM107_RS05670	COG0492	ferredoxin-NADP+ reductase activity
MANAM107_RS05675	COG0728	peptidoglycan biosynthetic process
MANAM107_RS05690	COG0617	tRNA 3'-terminal CCA addition
MANAM107_RS05700	COG3345	alpha-galactosidase
MANAM107_RS05710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MANAM107_RS05715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MANAM107_RS05745	COG0549	Belongs to the carbamate kinase family
MANAM107_RS05750	COG1953	Uracil, thiamine, allantoin
MANAM107_RS05755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MANAM107_RS05770	COG3959	Transketolase, thiamine diphosphate binding domain
MANAM107_RS05775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MANAM107_RS05785	COG2084	Dehydrogenase
MANAM107_RS05790	COG3960	tartronate-semialdehyde synthase activity
MANAM107_RS05795	COG1953	Uracil, thiamine, allantoin
MANAM107_RS05800	COG3739	integral membrane protein
MANAM107_RS05815	COG1950	PFAM Membrane protein of
MANAM107_RS05820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MANAM107_RS05825	COG0366	Alpha amylase catalytic
MANAM107_RS05860	COG1780	Probably involved in ribonucleotide reductase function
MANAM107_RS05865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MANAM107_RS05895	COG3328	transposase activity
MANAM107_RS05945	COG0471	metal ion transport
MANAM107_RS05960	COG0477	Major facilitator Superfamily
MANAM107_RS05965	COG3265	gluconokinase activity
MANAM107_RS05980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MANAM107_RS05990	COG2801	Transposase and inactivated derivatives
MANAM107_RS05990	COG3415	Transposase
MANAM107_RS06010	COG2211	Major facilitator Superfamily
MANAM107_RS06020	COG0672	)-iron permease
MANAM107_RS06030	COG2837	iron assimilation
MANAM107_RS06045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MANAM107_RS06055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MANAM107_RS06060	COG2011	ABC-type metal ion transport system permease component
MANAM107_RS06065	COG1464	Belongs to the NlpA lipoprotein family
MANAM107_RS06070	COG1929	Belongs to the glycerate kinase type-1 family
MANAM107_RS06080	COG5000	phosphorelay sensor kinase activity
MANAM107_RS06080	COG5002	protein histidine kinase activity
MANAM107_RS06100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MANAM107_RS06120	COG2197	response regulator
MANAM107_RS06130	COG1136	(ABC) transporter
MANAM107_RS06130	COG0577	efflux transmembrane transporter activity
MANAM107_RS06145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MANAM107_RS06150	COG0590	tRNA wobble adenosine to inosine editing
MANAM107_RS06150	COG0037	tRNA processing
MANAM107_RS06160	COG1643	Atp-dependent helicase
MANAM107_RS06185	COG2233	PERMEase
MANAM107_RS06225	COG3588	fructose-bisphosphate aldolase
MANAM107_RS06235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MANAM107_RS06245	COG1131	(ABC) transporter
MANAM107_RS06250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_RS06250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_RS06270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MANAM107_RS06280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MANAM107_RS06290	COG0113	porphobilinogen synthase activity
MANAM107_RS06315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MANAM107_RS06320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MANAM107_RS06325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MANAM107_RS06330	COG3253	May function as heme-dependent peroxidase
MANAM107_RS06330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MANAM107_RS06335	COG0247	lactate metabolic process
MANAM107_RS06335	COG2181	nitrate reductase activity
MANAM107_RS06355	COG3842	ATPase activity
MANAM107_RS06360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANAM107_RS06370	COG4166	transmembrane transport
MANAM107_RS06410	COG0326	Molecular chaperone. Has ATPase activity
MANAM107_RS06520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MANAM107_RS06560	COG1136	(ABC) transporter
MANAM107_RS06560	COG0577	efflux transmembrane transporter activity
MANAM107_RS06580	COG2337	Toxic component of a toxin-antitoxin (TA) module
MANAM107_RS06595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MANAM107_RS06620	COG0596	Alpha beta hydrolase
MANAM107_RS06630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MANAM107_RS06685	COG2205	protein histidine kinase activity
MANAM107_RS06690	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS06705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MANAM107_RS06705	COG1754	DNA topoisomerase type I activity
MANAM107_RS06715	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS06720	COG2205	protein histidine kinase activity
MANAM107_RS06725	COG2885	chlorophyll binding
MANAM107_RS06740	COG2188	Transcriptional regulator
MANAM107_RS06770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MANAM107_RS06775	COG0470	DNA polymerase III
MANAM107_RS06790	COG0252	asparaginase activity
MANAM107_RS06795	COG1113	amino acid transport
MANAM107_RS06810	COG0588	phosphoglycerate mutase activity
MANAM107_RS06820	COG5002	protein histidine kinase activity
MANAM107_RS06825	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS06835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MANAM107_RS06850	COG2197	response regulator
MANAM107_RS06855	COG3591	Belongs to the peptidase S1B family
MANAM107_RS06885	COG1309	transcriptional regulator
MANAM107_RS06905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MANAM107_RS06910	COG1643	Atp-dependent helicase
MANAM107_RS06930	COG3142	Participates in the control of copper homeostasis
MANAM107_RS06935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MANAM107_RS06940	COG2860	membrane
MANAM107_RS06955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MANAM107_RS06965	COG5650	phosphatidylinositol metabolic process
MANAM107_RS06970	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS06975	COG2205	protein histidine kinase activity
MANAM107_RS06980	COG0577	efflux transmembrane transporter activity
MANAM107_RS06980	COG1136	(ABC) transporter
MANAM107_RS07020	COG0714	Associated with various cellular activities
MANAM107_RS07085	COG0717	Belongs to the dCTP deaminase family
MANAM107_RS07095	COG2176	DNA-directed DNA polymerase activity
MANAM107_RS07120	COG1175	transmembrane transport
MANAM107_RS07125	COG0395	ABC-type sugar transport system, permease component
MANAM107_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
MANAM107_RS07200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MANAM107_RS07210	COG0191	fructose-bisphosphate aldolase activity
MANAM107_RS07215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MANAM107_RS07240	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MANAM107_RS07250	COG0151	Belongs to the GarS family
MANAM107_RS07265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MANAM107_RS07285	COG0047	phosphoribosylformylglycinamidine synthase activity
MANAM107_RS07290	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS07295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MANAM107_RS07315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MANAM107_RS07325	COG1349	DNA-binding transcription factor activity
MANAM107_RS07335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MANAM107_RS07335	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MANAM107_RS07335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MANAM107_RS07345	COG0557	exoribonuclease II activity
MANAM107_RS07355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MANAM107_RS07385	COG1132	(ABC) transporter
MANAM107_RS07390	COG1132	(ABC) transporter
MANAM107_RS07395	COG0577	efflux transmembrane transporter activity
MANAM107_RS07400	COG1136	(ABC) transporter
MANAM107_RS07410	COG1472	Belongs to the glycosyl hydrolase 3 family
MANAM107_RS07450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MANAM107_RS07470	COG0513	Belongs to the DEAD box helicase family
MANAM107_RS07475	COG2261	transglycosylase associated protein
MANAM107_RS07495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MANAM107_RS07530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MANAM107_RS07545	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS07555	COG3485	protocatechuate 3,4-dioxygenase
MANAM107_RS07560	COG0354	folic acid binding
MANAM107_RS07570	COG1490	D-aminoacyl-tRNA deacylase activity
MANAM107_RS07610	COG2197	response regulator
MANAM107_RS07620	COG4585	Histidine kinase
MANAM107_RS07630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MANAM107_RS07650	COG0297	glycogen (starch) synthase activity
MANAM107_RS07650	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS07660	COG0574	Belongs to the PEP-utilizing enzyme family
MANAM107_RS07660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MANAM107_RS07665	COG0714	Associated with various cellular activities
MANAM107_RS07685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MANAM107_RS07695	COG4585	Histidine kinase
MANAM107_RS07700	COG2197	response regulator
MANAM107_RS07715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MANAM107_RS07720	COG2873	o-acetylhomoserine
MANAM107_RS07730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MANAM107_RS07745	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MANAM107_RS07755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MANAM107_RS07760	COG0302	gtp cyclohydrolase
MANAM107_RS07775	COG0577	efflux transmembrane transporter activity
MANAM107_RS07780	COG1136	(ABC) transporter
MANAM107_RS07785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MANAM107_RS07795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MANAM107_RS07825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MANAM107_RS07830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MANAM107_RS07840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MANAM107_RS07855	COG3104	oligopeptide transport
MANAM107_RS07865	COG1556	Lactate utilization protein
MANAM107_RS07870	COG1139	Iron-sulfur cluster binding protein
MANAM107_RS07875	COG0247	lactate metabolic process
MANAM107_RS07880	COG1620	l-lactate permease
MANAM107_RS07890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MANAM107_RS07895	COG0698	ribose 5-phosphate isomerase
MANAM107_RS07910	COG1069	ribulokinase activity
MANAM107_RS07920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MANAM107_RS07935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MANAM107_RS07950	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MANAM107_RS07975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MANAM107_RS07990	COG0477	Major facilitator Superfamily
MANAM107_RS08025	COG2376	Dihydroxyacetone kinase
MANAM107_RS08035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MANAM107_RS08035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MANAM107_RS08035	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MANAM107_RS08040	COG2017	converts alpha-aldose to the beta-anomer
MANAM107_RS08060	COG3250	beta-galactosidase activity
MANAM107_RS08065	COG0569	domain protein
MANAM107_RS08070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MANAM107_RS08085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MANAM107_RS08095	COG0483	inositol monophosphate 1-phosphatase activity
MANAM107_RS08100	COG1609	Transcriptional regulator
MANAM107_RS08105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MANAM107_RS08115	COG1115	amino acid carrier protein
MANAM107_RS08125	COG0436	Aminotransferase
MANAM107_RS08150	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MANAM107_RS08155	COG0250	Participates in transcription elongation, termination and antitermination
MANAM107_RS08160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MANAM107_RS08165	COG0081	regulation of translation
MANAM107_RS08175	COG2885	chlorophyll binding
MANAM107_RS08185	COG2885	chlorophyll binding
MANAM107_RS08195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MANAM107_RS08200	COG0222	ribosome binding
MANAM107_RS08210	COG0085	RNA polymerase activity
MANAM107_RS08215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MANAM107_RS08225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MANAM107_RS08230	COG0049	tRNA binding
MANAM107_RS08235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MANAM107_RS08240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MANAM107_RS08265	COG0051	transcription antitermination factor activity, RNA binding
MANAM107_RS08275	COG0088	Forms part of the polypeptide exit tunnel
MANAM107_RS08280	COG0089	rRNA binding
MANAM107_RS08285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MANAM107_RS08290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MANAM107_RS08295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MANAM107_RS08300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MANAM107_RS08305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MANAM107_RS08310	COG0255	Belongs to the universal ribosomal protein uL29 family
MANAM107_RS08315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MANAM107_RS08320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MANAM107_RS08325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MANAM107_RS08330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MANAM107_RS08335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MANAM107_RS08345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MANAM107_RS08350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MANAM107_RS08355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MANAM107_RS08360	COG1841	ribosomal large subunit assembly
MANAM107_RS08375	COG0563	adenylate kinase activity
MANAM107_RS08380	COG0024	Methionine aminopeptidase
MANAM107_RS08390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MANAM107_RS08395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MANAM107_RS08400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MANAM107_RS08405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MANAM107_RS08410	COG0202	RNA polymerase activity
MANAM107_RS08415	COG0203	ribosomal protein L17
MANAM107_RS08425	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MANAM107_RS08430	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MANAM107_RS08440	COG0101	tRNA pseudouridine synthase activity
MANAM107_RS08445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MANAM107_RS08450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MANAM107_RS08465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MANAM107_RS08470	COG1072	(Pantothenic acid kinase))
MANAM107_RS08475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MANAM107_RS08480	COG0736	holo-[acyl-carrier-protein] synthase activity
MANAM107_RS08485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MANAM107_RS08490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MANAM107_RS08495	COG0802	atpase or kinase
MANAM107_RS08520	COG1053	succinate dehydrogenase
MANAM107_RS08525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MANAM107_RS08530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MANAM107_RS08545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MANAM107_RS08555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MANAM107_RS08575	COG0516	GMP reductase activity
MANAM107_RS08580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MANAM107_RS08595	COG0328	RNA-DNA hybrid ribonuclease activity
MANAM107_RS08605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MANAM107_RS08640	COG1082	Xylose isomerase domain protein TIM barrel
MANAM107_RS08645	COG2814	Major facilitator Superfamily
MANAM107_RS08650	COG0673	inositol 2-dehydrogenase activity
MANAM107_RS08665	COG0673	inositol 2-dehydrogenase activity
MANAM107_RS08670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MANAM107_RS08675	COG2188	Transcriptional regulator
MANAM107_RS08680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MANAM107_RS08690	COG3718	enzyme involved in inositol metabolism
MANAM107_RS08695	COG3962	Belongs to the TPP enzyme family
MANAM107_RS08735	COG0519	Catalyzes the synthesis of GMP from XMP
MANAM107_RS08735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MANAM107_RS08760	COG2267	carboxylic ester hydrolase activity
MANAM107_RS08770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MANAM107_RS08775	COG1116	anion transmembrane transporter activity
MANAM107_RS08775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MANAM107_RS08780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MANAM107_RS08815	COG2197	response regulator
MANAM107_RS08830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MANAM107_RS08840	COG0356	it plays a direct role in the translocation of protons across the membrane
MANAM107_RS08850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MANAM107_RS08855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MANAM107_RS08860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MANAM107_RS08865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MANAM107_RS08870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MANAM107_RS08890	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MANAM107_RS08915	COG3415	Transposase
MANAM107_RS08915	COG2801	Transposase and inactivated derivatives
MANAM107_RS08925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MANAM107_RS08930	COG0254	rRNA binding
MANAM107_RS08935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MANAM107_RS08940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MANAM107_RS08945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MANAM107_RS08960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MANAM107_RS08965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MANAM107_RS08970	COG1254	Belongs to the acylphosphatase family
MANAM107_RS08980	COG0577	efflux transmembrane transporter activity
MANAM107_RS08985	COG0577	efflux transmembrane transporter activity
MANAM107_RS08985	COG1136	(ABC) transporter
MANAM107_RS08995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MANAM107_RS09000	COG1349	DNA-binding transcription factor activity
MANAM107_RS09005	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MANAM107_RS09140	COG1744	ABC transporter substrate-binding protein PnrA-like
MANAM107_RS09145	COG3845	ABC transporter
MANAM107_RS09150	COG4603	Belongs to the binding-protein-dependent transport system permease family
MANAM107_RS09155	COG1079	Belongs to the binding-protein-dependent transport system permease family
MANAM107_RS09190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MANAM107_RS09200	COG1121	(ABC) transporter
MANAM107_RS09205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_RS09210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MANAM107_RS09235	COG1611	Belongs to the LOG family
MANAM107_RS09250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MANAM107_RS09265	COG2239	Acts as a magnesium transporter
MANAM107_RS09275	COG1082	Xylose isomerase domain protein TIM barrel
MANAM107_RS09280	COG1230	cation diffusion facilitator family transporter
MANAM107_RS09290	COG0006	proline dipeptidase activity
MANAM107_RS09295	COG0673	inositol 2-dehydrogenase activity
MANAM107_RS09305	COG2095	MarC family integral membrane protein
MANAM107_RS09310	COG0513	Belongs to the DEAD box helicase family
MANAM107_RS09335	COG0114	fumarate hydratase activity
MANAM107_RS09340	COG0778	Nitroreductase
MANAM107_RS09345	COG0346	lactoylglutathione lyase activity
MANAM107_RS09355	COG1174	glycine betaine transport
MANAM107_RS09360	COG1174	glycine betaine transport
MANAM107_RS09385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MANAM107_RS09415	COG1674	ftsk spoiiie
MANAM107_RS09420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MANAM107_RS09430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MANAM107_RS09435	COG0154	amidase activity
MANAM107_RS09440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MANAM107_RS09475	COG0569	domain protein
MANAM107_RS09475	COG2985	domain, Protein
MANAM107_RS09490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MANAM107_RS09495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_RS09505	COG0473	3-isopropylmalate dehydrogenase activity
MANAM107_RS09510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MANAM107_RS09515	COG1316	TRANSCRIPTIONal
MANAM107_RS09520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_RS09530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_RS09540	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS09550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MANAM107_RS09565	COG1086	Polysaccharide biosynthesis protein
MANAM107_RS09570	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS09575	COG1181	Belongs to the D-alanine--D-alanine ligase family
MANAM107_RS09585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MANAM107_RS09595	COG2271	Major facilitator Superfamily
MANAM107_RS09605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MANAM107_RS09610	COG0515	serine threonine protein kinase
MANAM107_RS09615	COG0842	Transport permease protein
MANAM107_RS09615	COG1131	(ABC) transporter
MANAM107_RS09615	COG1716	ATPase activity
MANAM107_RS09685	COG0629	single-stranded DNA binding
MANAM107_RS09695	COG2884	Cell division ATP-binding protein ftsE
MANAM107_RS09700	COG2177	Part of the ABC transporter FtsEX involved in
MANAM107_RS09725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MANAM107_RS09730	COG2233	PERMEase
MANAM107_RS09745	COG1175	transmembrane transport
MANAM107_RS09755	COG2186	Transcriptional regulator
MANAM107_RS09760	COG0747	negative chemotaxis
MANAM107_RS09765	COG0601	transmembrane transport
MANAM107_RS09770	COG0444	Belongs to the ABC transporter superfamily
MANAM107_RS09775	COG4608	Belongs to the ABC transporter superfamily
MANAM107_RS09780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MANAM107_RS09785	COG1940	carbohydrate kinase activity
MANAM107_RS09790	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MANAM107_RS09800	COG1131	(ABC) transporter
MANAM107_RS09810	COG0363	glucosamine-6-phosphate deaminase activity
MANAM107_RS09830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MANAM107_RS09840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MANAM107_RS09845	COG1234	tRNA 3'-trailer cleavage
MANAM107_RS09855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MANAM107_RS09860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MANAM107_RS09905	COG3304	Inner membrane component domain
MANAM107_RS09910	COG2040	homocysteine
MANAM107_RS09920	COG1115	amino acid carrier protein
MANAM107_RS09925	COG1115	amino acid carrier protein
MANAM107_RS09930	COG1115	amino acid carrier protein
MANAM107_RS09935	COG1115	amino acid carrier protein
MANAM107_RS09950	COG0179	Fumarylacetoacetate (FAA) hydrolase
MANAM107_RS09965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MANAM107_RS09995	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MANAM107_RS10005	COG1674	ftsk spoiiie
MANAM107_RS10020	COG1058	Belongs to the CinA family
MANAM107_RS10020	COG1546	Belongs to the CinA family
MANAM107_RS10025	COG1396	sequence-specific DNA binding
MANAM107_RS10035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MANAM107_RS10040	COG2137	regulation of response to DNA damage stimulus
MANAM107_RS10045	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MANAM107_RS10050	COG1653	transport
MANAM107_RS10070	COG1846	Transcriptional regulator
MANAM107_RS10070	COG1940	carbohydrate kinase activity
MANAM107_RS10075	COG1252	NADH dehydrogenase
MANAM107_RS10080	COG0509	glycine decarboxylation via glycine cleavage system
MANAM107_RS10085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MANAM107_RS10090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MANAM107_RS10090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MANAM107_RS10095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MANAM107_RS10100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_RS10100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MANAM107_RS10120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MANAM107_RS10125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MANAM107_RS10130	COG1114	Component of the transport system for branched-chain amino acids
MANAM107_RS10155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MANAM107_RS10170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MANAM107_RS10180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MANAM107_RS10185	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS10200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MANAM107_RS10205	COG0066	3-isopropylmalate dehydratase activity
MANAM107_RS10210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MANAM107_RS10215	COG0204	Acyl-transferase
MANAM107_RS10220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MANAM107_RS10230	COG1181	Belongs to the D-alanine--D-alanine ligase family
MANAM107_RS10245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MANAM107_RS10250	COG1461	Dihydroxyacetone kinase
MANAM107_RS10265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MANAM107_RS10280	COG0571	ribonuclease III activity
MANAM107_RS10285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MANAM107_RS10305	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MANAM107_RS10310	COG4988	ABC transporter
MANAM107_RS10320	COG1294	oxidase, subunit
MANAM107_RS10325	COG1271	oxidase subunit
MANAM107_RS10330	COG1530	ribonuclease E activity
MANAM107_RS10335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MANAM107_RS10340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MANAM107_RS10345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MANAM107_RS10350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MANAM107_RS10360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MANAM107_RS10370	COG0745	RESPONSE REGULATOR receiver
MANAM107_RS10375	COG5002	protein histidine kinase activity
MANAM107_RS10380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MANAM107_RS10395	COG1132	(ABC) transporter
MANAM107_RS10400	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS10420	COG1349	DNA-binding transcription factor activity
MANAM107_RS10430	COG1940	carbohydrate kinase activity
MANAM107_RS10435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MANAM107_RS10445	COG0799	negative regulation of ribosome biogenesis
MANAM107_RS10465	COG4989	oxidoreductase activity
MANAM107_RS10475	COG0789	Transcriptional regulator
MANAM107_RS10490	COG0813	purine-nucleoside phosphorylase activity
MANAM107_RS10495	COG0733	neurotransmitter:sodium symporter activity
MANAM107_RS10525	COG0537	adenosine 5'-monophosphoramidase activity
MANAM107_RS10530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_RS10535	COG0495	leucyl-tRNA aminoacylation
MANAM107_RS10555	COG3328	transposase activity
MANAM107_RS10560	COG1196	nuclear chromosome segregation
MANAM107_RS10565	COG0433	COG0433 Predicted ATPase
MANAM107_RS10585	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS10600	COG1307	EDD domain protein, DegV family
MANAM107_RS10620	COG4868	Belongs to the UPF0371 family
MANAM107_RS10625	COG0268	Binds directly to 16S ribosomal RNA
MANAM107_RS10645	COG2814	Major facilitator Superfamily
MANAM107_RS10645	COG0477	Major facilitator Superfamily
MANAM107_RS10655	COG0159	tryptophan synthase activity
MANAM107_RS10670	COG0512	Glutamine amidotransferase of anthranilate synthase
MANAM107_RS10675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MANAM107_RS10700	COG0481	GTPase activity
MANAM107_RS10710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MANAM107_RS10735	COG1420	regulation of RNA biosynthetic process
MANAM107_RS10740	COG0484	heat shock protein binding
MANAM107_RS10765	COG1131	(ABC) transporter
MANAM107_RS10785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MANAM107_RS10795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MANAM107_RS10800	COG0506	proline dehydrogenase activity
MANAM107_RS10800	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MANAM107_RS10800	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MANAM107_RS10805	COG1131	(ABC) transporter
MANAM107_RS10815	COG1476	TRANSCRIPTIONal
MANAM107_RS10820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MANAM107_RS10825	COG1381	Involved in DNA repair and RecF pathway recombination
MANAM107_RS10830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MANAM107_RS10840	COG0640	Transcriptional regulator
MANAM107_RS10850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_RS10855	COG1121	(ABC) transporter
MANAM107_RS10860	COG0803	Belongs to the bacterial solute-binding protein 9 family
MANAM107_RS10865	COG0423	glycine-tRNA ligase activity
MANAM107_RS10875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MANAM107_RS10885	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MANAM107_RS10895	COG0560	Phosphoserine phosphatase
MANAM107_RS10905	COG0297	glycogen (starch) synthase activity
MANAM107_RS10915	COG1119	ATPase activity
MANAM107_RS10935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MANAM107_RS10950	COG2326	polyphosphate kinase activity
MANAM107_RS10955	COG1263	PTS System
MANAM107_RS10955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_RS10955	COG2190	(PTS) system
MANAM107_RS10965	COG0488	(ABC) transporter
MANAM107_RS10975	COG0545	Peptidyl-prolyl cis-trans isomerase
MANAM107_RS11035	COG0205	6-phosphofructokinase activity
MANAM107_RS11040	COG2409	Drug exporters of the RND superfamily
MANAM107_RS11050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MANAM107_RS11055	COG0515	serine threonine protein kinase
MANAM107_RS11055	COG2815	serine threonine protein kinase
MANAM107_RS11060	COG0142	geranyltranstransferase activity
MANAM107_RS11065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANAM107_RS11090	COG1929	Belongs to the glycerate kinase type-1 family
MANAM107_RS11100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MANAM107_RS11145	COG0569	domain protein
MANAM107_RS11150	COG0531	amino acid
MANAM107_RS11155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MANAM107_RS11165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MANAM107_RS11185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MANAM107_RS11190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MANAM107_RS11195	COG4221	oxidoreductase activity
MANAM107_RS11200	COG1881	PFAM PEBP family protein
MANAM107_RS11215	COG0671	phosphoesterase, PA-phosphatase related
MANAM107_RS11220	COG1435	thymidine kinase activity
MANAM107_RS11240	COG0587	DNA-directed DNA polymerase activity
MANAM107_RS11270	COG0738	Major facilitator superfamily
MANAM107_RS11300	COG0667	Aldo Keto reductase
MANAM107_RS11320	COG0517	IMP dehydrogenase activity
MANAM107_RS11320	COG1994	Peptidase M50
MANAM107_RS11325	COG2814	Major facilitator Superfamily
MANAM107_RS11340	COG1222	aaa ATPase
MANAM107_RS11345	COG4122	O-methyltransferase activity
MANAM107_RS11355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MANAM107_RS11365	COG0107	imidazoleglycerol-phosphate synthase activity
MANAM107_RS11390	COG0134	indole-3-glycerol-phosphate synthase activity
MANAM107_RS11395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MANAM107_RS11425	COG2050	protein possibly involved in aromatic compounds catabolism
MANAM107_RS11435	COG0539	negative regulation of cytoplasmic translation
MANAM107_RS11445	COG2076	Multidrug Resistance protein
MANAM107_RS11450	COG0237	dephospho-CoA kinase activity
MANAM107_RS11455	COG0556	nucleotide-excision repair
MANAM107_RS11470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MANAM107_RS11480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MANAM107_RS11490	COG2226	methyltransferase
MANAM107_RS11525	COG1882	Formate acetyltransferase
MANAM107_RS11595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MANAM107_RS11605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MANAM107_RS11610	COG1560	Kdo2-lipid A biosynthetic process
MANAM107_RS11615	COG0438	transferase activity, transferring glycosyl groups
MANAM107_RS11630	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MANAM107_RS11640	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MANAM107_RS11645	COG0217	transcriptional regulatory protein
MANAM107_RS11650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MANAM107_RS11655	COG0632	four-way junction helicase activity
MANAM107_RS11660	COG2255	four-way junction helicase activity
MANAM107_RS11670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MANAM107_RS11675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MANAM107_RS11680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MANAM107_RS11685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MANAM107_RS11695	COG0789	Transcriptional regulator
MANAM107_RS11700	COG1196	nuclear chromosome segregation
MANAM107_RS11710	COG0488	(ABC) transporter
MANAM107_RS11760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MANAM107_RS11780	COG0584	glycerophosphoryl diester phosphodiesterase
MANAM107_RS11785	COG0009	L-threonylcarbamoyladenylate synthase
MANAM107_RS11790	COG2409	Drug exporters of the RND superfamily
MANAM107_RS11800	COG0730	response to heat
MANAM107_RS11805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MANAM107_RS11810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MANAM107_RS11815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MANAM107_RS11830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MANAM107_RS11845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MANAM107_RS11850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MANAM107_RS11875	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MANAM107_RS11930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MANAM107_RS11935	COG0540	Belongs to the ATCase OTCase family
MANAM107_RS11940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MANAM107_RS11945	COG0284	orotidine-5'-phosphate decarboxylase activity
MANAM107_RS11955	COG0194	GDP metabolic process
MANAM107_RS11960	COG1758	RNA polymerase activity
MANAM107_RS11970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MANAM107_RS11975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MANAM107_RS12005	COG1834	amidinotransferase
MANAM107_RS12010	COG0549	Belongs to the carbamate kinase family
MANAM107_RS12015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MANAM107_RS12020	COG2235	arginine
MANAM107_RS12025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MANAM107_RS12035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MANAM107_RS12040	COG4770	biotin carboxylase activity
MANAM107_RS12045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MANAM107_RS12050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MANAM107_RS12065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MANAM107_RS12070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MANAM107_RS12075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MANAM107_RS12080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MANAM107_RS12085	COG0140	phosphoribosyl-ATP diphosphatase activity
MANAM107_RS12095	COG1131	(ABC) transporter
MANAM107_RS12105	COG2197	response regulator
MANAM107_RS12155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MANAM107_RS12180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MANAM107_RS12190	COG3022	response to hydroperoxide
MANAM107_RS12210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MANAM107_RS12215	COG0174	glutamine synthetase
MANAM107_RS12220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MANAM107_RS12230	COG1126	abc transporter atp-binding protein
MANAM107_RS12235	COG0765	amino acid transport
MANAM107_RS12240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MANAM107_RS12255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MANAM107_RS12260	COG0321	lipoyl(octanoyl) transferase activity
MANAM107_RS12270	COG0508	dehydrogenase complex catalyzes the overall conversion of
MANAM107_RS12275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MANAM107_RS12280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MANAM107_RS12290	COG0583	DNA-binding transcription factor activity
MANAM107_RS12295	COG0667	Aldo Keto reductase
MANAM107_RS12320	COG0322	excinuclease ABC activity
MANAM107_RS12325	COG3711	transcriptional antiterminator
MANAM107_RS12330	COG1263	PTS System
MANAM107_RS12330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_RS12330	COG2190	(PTS) system
MANAM107_RS12340	COG1660	Displays ATPase and GTPase activities
MANAM107_RS12350	COG1481	regulation of sporulation
MANAM107_RS12355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MANAM107_RS12365	COG0149	triose-phosphate isomerase activity
MANAM107_RS12370	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MANAM107_RS12385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MANAM107_RS12390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MANAM107_RS12400	COG0287	Prephenate dehydrogenase
MANAM107_RS12405	COG1160	GTP binding
MANAM107_RS12435	COG0166	Belongs to the GPI family
MANAM107_RS12445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MANAM107_RS12475	COG0662	Cupin 2, conserved barrel domain protein
MANAM107_RS12485	COG1201	RNA secondary structure unwinding
MANAM107_RS12535	COG0363	glucosamine-6-phosphate deaminase activity
MANAM107_RS12550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MANAM107_RS12560	COG1716	ATPase activity
MANAM107_RS12575	COG0443	Heat shock 70 kDa protein
MANAM107_RS12590	COG1621	beta-fructofuranosidase activity
MANAM107_RS12595	COG2190	(PTS) system
MANAM107_RS12595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_RS12595	COG1263	PTS System
MANAM107_RS12600	COG1609	Transcriptional regulator
MANAM107_RS12610	COG1136	(ABC) transporter
MANAM107_RS12615	COG0577	efflux transmembrane transporter activity
MANAM107_RS12630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MANAM107_RS12635	COG1487	ribonuclease activity
MANAM107_RS12660	COG0205	6-phosphofructokinase activity
MANAM107_RS12670	COG1216	Glycosyl transferase, family 2
MANAM107_RS12680	COG4581	dead DEAH box helicase
MANAM107_RS12690	COG0805	protein transport
MANAM107_RS12700	COG2378	regulation of single-species biofilm formation
MANAM107_RS12785	COG3415	Transposase
MANAM107_RS12785	COG2801	Transposase and inactivated derivatives
MANAM107_RS12805	COG0542	response to heat
MANAM107_RS12825	COG3328	transposase activity
MANAM107_RS12860	COG0730	response to heat
MANAM107_RS12865	COG0641	radical SAM
MANAM107_RS12870	COG3119	arylsulfatase activity
MANAM107_RS12875	COG0395	ABC-type sugar transport system, permease component
MANAM107_RS12880	COG1175	transmembrane transport
MANAM107_RS12905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MANAM107_RS12915	COG1027	Aspartate ammonia-lyase
MANAM107_RS12925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MANAM107_RS12955	COG0358	DNA primase activity
MANAM107_RS12970	COG2182	Extracellular solute-binding protein
MANAM107_RS12975	COG1175	transmembrane transport
MANAM107_RS12980	COG3833	ABC-type maltose transport systems, permease component
MANAM107_RS12990	COG1609	Transcriptional regulator
MANAM107_RS13010	COG3480	Lon protease (S16) C-terminal proteolytic domain
MANAM107_RS13035	COG1316	TRANSCRIPTIONal
MANAM107_RS13040	COG1201	RNA secondary structure unwinding
MANAM107_RS13060	COG4585	Histidine kinase
MANAM107_RS13080	COG0181	hydroxymethylbilane synthase activity
MANAM107_RS13090	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_RS13090	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_RS13105	COG2801	Transposase and inactivated derivatives
MANAM107_RS13115	COG4585	Histidine kinase