locus-tag	class	description
BK816_RS00010	COG0592	DNA-directed DNA polymerase activity
BK816_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BK816_RS00025	COG0187	DNA topoisomerase II activity
BK816_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK816_RS00085	COG3764	Sortase (surface protein transpeptidase)
BK816_RS00095	COG0515	serine threonine protein kinase
BK816_RS00100	COG0768	penicillin binding
BK816_RS00115	COG1716	ATPase activity
BK816_RS00120	COG1716	ATPase activity
BK816_RS00130	COG1397	ADP-ribosylglycohydrolase
BK816_RS00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BK816_RS00140	COG1854	S-ribosylhomocysteine lyase activity
BK816_RS00145	COG1760	l-serine dehydratase
BK816_RS00150	COG0531	amino acid
BK816_RS00160	COG1780	Probably involved in ribonucleotide reductase function
BK816_RS00180	COG1132	(ABC) transporter
BK816_RS00220	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BK816_RS00245	COG1132	(ABC) transporter
BK816_RS00250	COG1132	(ABC) transporter
BK816_RS00255	COG0733	neurotransmitter:sodium symporter activity
BK816_RS00275	COG1045	serine acetyltransferase
BK816_RS00280	COG0534	Mate efflux family protein
BK816_RS00285	COG0305	Participates in initiation and elongation during chromosome replication
BK816_RS00305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BK816_RS00315	COG0351	phosphomethylpyrimidine kinase
BK816_RS00320	COG3177	Filamentation induced by cAMP protein fic
BK816_RS00350	COG1136	(ABC) transporter
BK816_RS00385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BK816_RS00420	COG1215	transferase activity, transferring glycosyl groups
BK816_RS00440	COG0463	Glycosyl transferase, family 2
BK816_RS00480	COG1134	teichoic acid transport
BK816_RS00500	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BK816_RS00505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BK816_RS00510	COG1316	TRANSCRIPTIONal
BK816_RS00530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BK816_RS00545	COG1950	PFAM Membrane protein of
BK816_RS00585	COG1408	metallophosphoesterase
BK816_RS00590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK816_RS00655	COG1111	helicase
BK816_RS00655	COG1205	dead DEAH box helicase
BK816_RS00660	COG0527	aspartate kinase activity
BK816_RS00665	COG0460	homoserine dehydrogenase
BK816_RS00675	COG0083	homoserine kinase activity
BK816_RS00685	COG2233	PERMEase
BK816_RS00705	COG0463	Glycosyl transferase, family 2
BK816_RS00725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK816_RS00730	COG1121	(ABC) transporter
BK816_RS00755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BK816_RS00760	COG3345	alpha-galactosidase
BK816_RS00790	COG1136	(ABC) transporter
BK816_RS00790	COG0577	efflux transmembrane transporter activity
BK816_RS00800	COG1136	(ABC) transporter
BK816_RS00810	COG2197	response regulator
BK816_RS00855	COG1132	(ABC) transporter
BK816_RS00860	COG1132	(ABC) transporter
BK816_RS00875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BK816_RS00885	COG1131	(ABC) transporter
BK816_RS00890	COG1136	(ABC) transporter
BK816_RS00900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BK816_RS01005	COG4695	Portal protein
BK816_RS01015	COG4626	Terminase
BK816_RS01015	COG1802	Transcriptional regulator
BK816_RS01045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BK816_RS01060	COG3409	Peptidoglycan-binding domain 1 protein
BK816_RS01165	COG1136	(ABC) transporter
BK816_RS01225	COG1846	Transcriptional regulator
BK816_RS01230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK816_RS01240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK816_RS01265	COG0477	Major facilitator Superfamily
BK816_RS01270	COG1904	glucuronate isomerase
BK816_RS01275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BK816_RS01280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK816_RS01285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK816_RS01295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK816_RS01345	COG0151	Belongs to the GarS family
BK816_RS01355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BK816_RS01365	COG0047	phosphoribosylformylglycinamidine synthase activity
BK816_RS01370	COG1597	lipid kinase activity
BK816_RS01375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BK816_RS01380	COG0561	phosphatase activity
BK816_RS01425	COG1940	carbohydrate kinase activity
BK816_RS01430	COG0641	radical SAM
BK816_RS01445	COG2252	PERMEase
BK816_RS01450	COG2814	Major facilitator Superfamily
BK816_RS01455	COG1609	Transcriptional regulator
BK816_RS01460	COG3119	arylsulfatase activity
BK816_RS01470	COG0306	phosphate transporter
BK816_RS01500	COG0354	folic acid binding
BK816_RS01510	COG1490	D-aminoacyl-tRNA deacylase activity
BK816_RS01535	COG0701	Predicted permease
BK816_RS01545	COG1785	Belongs to the alkaline phosphatase family
BK816_RS01560	COG1401	restriction endodeoxyribonuclease activity
BK816_RS01565	COG4268	DNA restriction-modification system
BK816_RS01570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BK816_RS01615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BK816_RS01620	COG1061	Type III restriction enzyme res subunit
BK816_RS01640	COG0454	-acetyltransferase
BK816_RS01640	COG0456	acetyltransferase
BK816_RS01675	COG2222	sugar isomerase
BK816_RS01685	COG4821	SIS domain
BK816_RS01715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK816_RS01715	COG0574	Belongs to the PEP-utilizing enzyme family
BK816_RS01725	COG2911	Protein conserved in bacteria
BK816_RS01725	COG3266	domain, Protein
BK816_RS01725	COG1361	Conserved repeat domain
BK816_RS01735	COG0477	Major facilitator Superfamily
BK816_RS01740	COG0717	Belongs to the dCTP deaminase family
BK816_RS01750	COG0247	lactate metabolic process
BK816_RS01750	COG2181	nitrate reductase activity
BK816_RS01760	COG0435	Glutathione S-transferase
BK816_RS01780	COG1404	Belongs to the peptidase S8 family
BK816_RS01785	COG0205	6-phosphofructokinase activity
BK816_RS01790	COG0644	oxidoreductase
BK816_RS01800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BK816_RS01805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BK816_RS01810	COG0649	NAD binding
BK816_RS01820	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BK816_RS01825	COG1034	ATP synthesis coupled electron transport
BK816_RS01830	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BK816_RS01835	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BK816_RS01840	COG0839	Belongs to the complex I subunit 6 family
BK816_RS01845	COG0713	ATP synthesis coupled electron transport
BK816_RS01850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BK816_RS01860	COG1007	ATP synthesis coupled electron transport
BK816_RS01865	COG0142	geranyltranstransferase activity
BK816_RS01880	COG0501	Belongs to the peptidase M48B family
BK816_RS01885	COG1666	GTP binding
BK816_RS01905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK816_RS01915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BK816_RS01920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BK816_RS01930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BK816_RS01935	COG2267	carboxylic ester hydrolase activity
BK816_RS01940	COG0436	Aminotransferase
BK816_RS01960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BK816_RS01965	COG0081	regulation of translation
BK816_RS01970	COG0366	Alpha amylase catalytic
BK816_RS01970	COG1470	cell adhesion involved in biofilm formation
BK816_RS01975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BK816_RS01980	COG0222	ribosome binding
BK816_RS01985	COG1132	(ABC) transporter
BK816_RS01990	COG4988	ABC transporter
BK816_RS01995	COG0085	RNA polymerase activity
BK816_RS02000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK816_RS02025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BK816_RS02030	COG0049	tRNA binding
BK816_RS02035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK816_RS02040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BK816_RS02045	COG0051	transcription antitermination factor activity, RNA binding
BK816_RS02050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BK816_RS02055	COG0088	Forms part of the polypeptide exit tunnel
BK816_RS02060	COG0089	rRNA binding
BK816_RS02065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BK816_RS02070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BK816_RS02080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BK816_RS02085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BK816_RS02090	COG0255	Belongs to the universal ribosomal protein uL29 family
BK816_RS02095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BK816_RS02100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BK816_RS02105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BK816_RS02110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BK816_RS02115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BK816_RS02120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BK816_RS02130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BK816_RS02135	COG1841	ribosomal large subunit assembly
BK816_RS02140	COG0200	Binds to the 23S rRNA
BK816_RS02150	COG0563	adenylate kinase activity
BK816_RS02155	COG0024	Methionine aminopeptidase
BK816_RS02160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BK816_RS02165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BK816_RS02170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BK816_RS02175	COG0202	RNA polymerase activity
BK816_RS02180	COG0203	ribosomal protein L17
BK816_RS02190	COG0101	tRNA pseudouridine synthase activity
BK816_RS02195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BK816_RS02200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BK816_RS02215	COG1072	(Pantothenic acid kinase))
BK816_RS02220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BK816_RS02225	COG0802	atpase or kinase
BK816_RS02235	COG1214	PFAM Peptidase M22, glycoprotease
BK816_RS02235	COG0456	acetyltransferase
BK816_RS02245	COG1053	succinate dehydrogenase
BK816_RS02250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BK816_RS02255	COG2848	UPF0210 protein
BK816_RS02260	COG3830	Belongs to the UPF0237 family
BK816_RS02280	COG0483	inositol monophosphate 1-phosphatase activity
BK816_RS02285	COG1556	Lactate utilization protein
BK816_RS02290	COG1139	Iron-sulfur cluster binding protein
BK816_RS02295	COG0247	lactate metabolic process
BK816_RS02300	COG1620	l-lactate permease
BK816_RS02305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BK816_RS02320	COG1842	Phage shock protein A
BK816_RS02355	COG1970	mechanosensitive ion channel activity
BK816_RS02360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BK816_RS02365	COG0303	'Molybdopterin
BK816_RS02370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK816_RS02405	COG2911	Protein conserved in bacteria
BK816_RS02405	COG3266	domain, Protein
BK816_RS02405	COG1361	Conserved repeat domain
BK816_RS02410	COG1619	proteins homologs of microcin C7 resistance protein MccF
BK816_RS02460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BK816_RS02470	COG2911	Protein conserved in bacteria
BK816_RS02470	COG1361	Conserved repeat domain
BK816_RS02470	COG3266	domain, Protein
BK816_RS02490	COG2176	DNA-directed DNA polymerase activity
BK816_RS02500	COG0516	GMP reductase activity
BK816_RS02505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BK816_RS02505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BK816_RS02515	COG2151	metal-sulfur cluster biosynthetic enzyme
BK816_RS02515	COG0489	protein tyrosine kinase activity
BK816_RS02525	COG2239	Acts as a magnesium transporter
BK816_RS02535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BK816_RS02535	COG0131	Imidazoleglycerol-phosphate dehydratase
BK816_RS02540	COG0006	proline dipeptidase activity
BK816_RS02560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BK816_RS02570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BK816_RS02590	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BK816_RS02640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BK816_RS02650	COG2884	Cell division ATP-binding protein ftsE
BK816_RS02655	COG2177	Part of the ABC transporter FtsEX involved in
BK816_RS02660	COG0739	heme binding
BK816_RS02720	COG0363	glucosamine-6-phosphate deaminase activity
BK816_RS02740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BK816_RS02745	COG1234	tRNA 3'-trailer cleavage
BK816_RS02750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BK816_RS02755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BK816_RS02775	COG1686	Belongs to the peptidase S11 family
BK816_RS02795	COG1615	UPF0182 protein
BK816_RS02805	COG2814	Major facilitator Superfamily
BK816_RS02820	COG0561	phosphatase activity
BK816_RS02830	COG1643	Atp-dependent helicase
BK816_RS02845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BK816_RS02850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BK816_RS02880	COG1674	ftsk spoiiie
BK816_RS02885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BK816_RS02890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK816_RS02895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK816_RS02900	COG0154	amidase activity
BK816_RS02905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK816_RS02940	COG2985	domain, Protein
BK816_RS02940	COG0569	domain protein
BK816_RS02945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK816_RS02955	COG1115	amino acid carrier protein
BK816_RS02960	COG1115	amino acid carrier protein
BK816_RS02970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK816_RS02985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BK816_RS03000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BK816_RS03005	COG1181	Belongs to the D-alanine--D-alanine ligase family
BK816_RS03045	COG0629	single-stranded DNA binding
BK816_RS03070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK816_RS03075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK816_RS03080	COG2188	Transcriptional regulator
BK816_RS03085	COG3590	peptidase
BK816_RS03090	COG0698	ribose 5-phosphate isomerase
BK816_RS03095	COG1739	Uncharacterized protein family UPF0029
BK816_RS03105	COG2755	lipolytic protein G-D-S-L family
BK816_RS03105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BK816_RS03125	COG2837	iron assimilation
BK816_RS03135	COG0544	peptidyl-prolyl cis-trans isomerase activity
BK816_RS03140	COG0740	serine-type endopeptidase activity
BK816_RS03145	COG0740	serine-type endopeptidase activity
BK816_RS03150	COG2115	Belongs to the xylose isomerase family
BK816_RS03155	COG1070	Carbohydrate kinase
BK816_RS03160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BK816_RS03165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BK816_RS03170	COG0287	Prephenate dehydrogenase
BK816_RS03170	COG1605	Chorismate mutase
BK816_RS03180	COG1362	aminopeptidase activity
BK816_RS03190	COG0733	neurotransmitter:sodium symporter activity
BK816_RS03220	COG1217	gtp-binding protein TYPA
BK816_RS03240	COG2171	N-acyltransferase activity
BK816_RS03245	COG0424	maF-like protein
BK816_RS03255	COG0745	RESPONSE REGULATOR receiver
BK816_RS03270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BK816_RS03275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BK816_RS03280	COG1316	TRANSCRIPTIONal
BK816_RS03350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BK816_RS03365	COG1216	Glycosyl transferase, family 2
BK816_RS03380	COG0463	Glycosyl transferase, family 2
BK816_RS03380	COG1216	Glycosyl transferase, family 2
BK816_RS03430	COG0714	Associated with various cellular activities
BK816_RS03455	COG5002	protein histidine kinase activity
BK816_RS03470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BK816_RS03475	COG0653	protein targeting
BK816_RS03515	COG0419	ATPase involved in DNA repair
BK816_RS03520	COG0420	3'-5' exonuclease activity
BK816_RS03525	COG1162	GTPase activity
BK816_RS03530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BK816_RS03540	COG1595	DNA-templated transcription, initiation
BK816_RS03550	COG1361	Conserved repeat domain
BK816_RS03560	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK816_RS03560	COG0567	Dehydrogenase, E1 component
BK816_RS03565	COG1253	flavin adenine dinucleotide binding
BK816_RS03575	COG1196	nuclear chromosome segregation
BK816_RS03575	COG0741	lytic transglycosylase activity
BK816_RS03575	COG0739	heme binding
BK816_RS03580	COG0584	glycerophosphoryl diester phosphodiesterase
BK816_RS03595	COG0018	arginyl-trna synthetase
BK816_RS03625	COG0254	rRNA binding
BK816_RS03630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BK816_RS03635	COG2890	protein-(glutamine-N5) methyltransferase activity
BK816_RS03655	COG0356	it plays a direct role in the translocation of protons across the membrane
BK816_RS03660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK816_RS03670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK816_RS03675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BK816_RS03680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BK816_RS03685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BK816_RS03690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BK816_RS03700	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
BK816_RS03705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BK816_RS03735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BK816_RS03740	COG0366	Alpha amylase catalytic
BK816_RS03745	COG0180	Tryptophanyl-tRNA synthetase
BK816_RS03760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BK816_RS03770	COG0482	sulfurtransferase activity
BK816_RS03810	COG0495	leucyl-tRNA aminoacylation
BK816_RS03830	COG0285	dihydrofolate synthase activity
BK816_RS03860	COG0228	four-way junction DNA binding
BK816_RS03865	COG1837	Belongs to the UPF0109 family
BK816_RS03870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BK816_RS03875	COG0336	Belongs to the RNA methyltransferase TrmD family
BK816_RS03880	COG0335	large ribosomal subunit rRNA binding
BK816_RS03890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK816_RS03900	COG0792	nuclease activity
BK816_RS03915	COG4974	Belongs to the 'phage' integrase family
BK816_RS03930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK816_RS03940	COG1968	undecaprenyl-diphosphatase activity
BK816_RS03960	COG1222	aaa ATPase
BK816_RS03965	COG4122	O-methyltransferase activity
BK816_RS03990	COG0469	pyruvate kinase activity
BK816_RS04015	COG2050	protein possibly involved in aromatic compounds catabolism
BK816_RS04025	COG1125	glycine betaine transport
BK816_RS04025	COG0517	IMP dehydrogenase activity
BK816_RS04035	COG0246	Mannitol dehydrogenase
BK816_RS04040	COG1312	Catalyzes the dehydration of D-mannonate
BK816_RS04045	COG0800	Aldolase
BK816_RS04050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK816_RS04065	COG1175	transmembrane transport
BK816_RS04070	COG1653	transport
BK816_RS04085	COG2409	Drug exporters of the RND superfamily
BK816_RS04095	COG1966	Carbon starvation protein
BK816_RS04110	COG0539	negative regulation of cytoplasmic translation
BK816_RS04130	COG1472	Belongs to the glycosyl hydrolase 3 family
BK816_RS04140	COG0556	nucleotide-excision repair
BK816_RS04155	COG0385	Bile acid
BK816_RS04170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BK816_RS04175	COG1022	Amp-dependent synthetase and ligase
BK816_RS04180	COG0174	glutamine synthetase
BK816_RS04185	COG0322	excinuclease ABC activity
BK816_RS04190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BK816_RS04195	COG1660	Displays ATPase and GTPase activities
BK816_RS04200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BK816_RS04205	COG1481	regulation of sporulation
BK816_RS04210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BK816_RS04215	COG0126	phosphoglycerate kinase activity
BK816_RS04220	COG0149	triose-phosphate isomerase activity
BK816_RS04255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BK816_RS04260	COG0009	L-threonylcarbamoyladenylate synthase
BK816_RS04275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BK816_RS04300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BK816_RS04310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BK816_RS04325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BK816_RS04330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BK816_RS04335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BK816_RS04340	COG0540	Belongs to the ATCase OTCase family
BK816_RS04345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BK816_RS04355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BK816_RS04360	COG0284	orotidine-5'-phosphate decarboxylase activity
BK816_RS04365	COG0194	GDP metabolic process
BK816_RS04370	COG1758	RNA polymerase activity
BK816_RS04380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BK816_RS04385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BK816_RS04390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BK816_RS04400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BK816_RS04405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BK816_RS04410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BK816_RS04420	COG4581	dead DEAH box helicase
BK816_RS04480	COG1160	GTP binding
BK816_RS04485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BK816_RS04505	COG0124	histidyl-tRNA synthetase
BK816_RS04515	COG1196	nuclear chromosome segregation
BK816_RS04520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BK816_RS04525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK816_RS04530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BK816_RS04535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BK816_RS04545	COG2255	four-way junction helicase activity
BK816_RS04550	COG0632	four-way junction helicase activity
BK816_RS04555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BK816_RS04560	COG0217	transcriptional regulatory protein
BK816_RS04570	COG0438	transferase activity, transferring glycosyl groups
BK816_RS04580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BK816_RS04590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK816_RS04670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BK816_RS04680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK816_RS04685	COG0531	amino acid
BK816_RS04690	COG0569	domain protein
BK816_RS04735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK816_RS04750	COG0187	DNA topoisomerase II activity
BK816_RS04760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BK816_RS04765	COG0142	geranyltranstransferase activity
BK816_RS04770	COG0515	serine threonine protein kinase
BK816_RS04770	COG2815	serine threonine protein kinase
BK816_RS04775	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BK816_RS04830	COG0167	dihydroorotate dehydrogenase activity
BK816_RS04840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK816_RS04845	COG0813	purine-nucleoside phosphorylase activity
BK816_RS04860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BK816_RS04875	COG0598	Magnesium transport protein CorA
BK816_RS04880	COG4868	Belongs to the UPF0371 family
BK816_RS04890	COG0519	Catalyzes the synthesis of GMP from XMP
BK816_RS04890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BK816_RS04895	COG0686	Belongs to the AlaDH PNT family
BK816_RS04900	COG1113	amino acid transport
BK816_RS04910	COG0431	NADPH-dependent FMN reductase
BK816_RS04935	COG1757	Na H antiporter
BK816_RS04940	COG1275	C4-dicarboxylate transporter malic acid transport protein
BK816_RS04955	COG1136	(ABC) transporter
BK816_RS04980	COG0799	negative regulation of ribosome biogenesis
BK816_RS04985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BK816_RS04995	COG1940	carbohydrate kinase activity
BK816_RS05000	COG1349	DNA-binding transcription factor activity
BK816_RS05005	COG5426	von Willebrand factor, type A
BK816_RS05010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BK816_RS05015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BK816_RS05020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BK816_RS05025	COG1530	ribonuclease E activity
BK816_RS05030	COG1271	oxidase subunit
BK816_RS05035	COG1294	oxidase, subunit
BK816_RS05040	COG4988	ABC transporter
BK816_RS05045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BK816_RS05070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BK816_RS05075	COG1438	arginine binding
BK816_RS05085	COG2188	Transcriptional regulator
BK816_RS05090	COG0747	negative chemotaxis
BK816_RS05095	COG0601	transmembrane transport
BK816_RS05100	COG0444	Belongs to the ABC transporter superfamily
BK816_RS05105	COG4608	Belongs to the ABC transporter superfamily
BK816_RS05110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BK816_RS05120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BK816_RS05150	COG3022	response to hydroperoxide
BK816_RS05175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BK816_RS05190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BK816_RS05195	COG1027	Aspartate ammonia-lyase
BK816_RS05210	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BK816_RS05220	COG0442	prolyl-tRNA aminoacylation
BK816_RS05225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BK816_RS05230	COG0750	zinc metalloprotease
BK816_RS05235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BK816_RS05245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BK816_RS05250	COG0575	Belongs to the CDS family
BK816_RS05255	COG0233	cytoplasmic translational termination
BK816_RS05265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BK816_RS05270	COG0052	Belongs to the universal ribosomal protein uS2 family
BK816_RS05295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BK816_RS05300	COG1435	thymidine kinase activity
BK816_RS05315	COG1881	PFAM PEBP family protein
BK816_RS05320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BK816_RS05330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BK816_RS05335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK816_RS05340	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK816_RS05360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK816_RS05365	COG0765	amino acid transport
BK816_RS05375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BK816_RS05380	COG0174	glutamine synthetase
BK816_RS05395	COG1119	ATPase activity
BK816_RS05400	COG0297	glycogen (starch) synthase activity
BK816_RS05405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BK816_RS05420	COG0488	(ABC) transporter
BK816_RS05435	COG1597	lipid kinase activity
BK816_RS05440	COG2151	metal-sulfur cluster biosynthetic enzyme
BK816_RS05445	COG0822	iron-sulfur transferase activity
BK816_RS05450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BK816_RS05455	COG0396	ATPase activity
BK816_RS05465	COG0719	Fe-S assembly protein
BK816_RS05480	COG0494	nUDIX hydrolase
BK816_RS05510	COG0647	UMP catabolic process
BK816_RS05520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BK816_RS05525	COG0571	ribonuclease III activity
BK816_RS05530	COG1399	metal-binding, possibly nucleic acid-binding protein
BK816_RS05560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BK816_RS05575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BK816_RS05580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK816_RS05585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BK816_RS05590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BK816_RS05610	COG2501	S4 domain
BK816_RS05625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK816_RS05630	COG3599	regulation of cell shape
BK816_RS05640	COG1799	cell septum assembly
BK816_RS05645	COG1496	oxidoreductase activity
BK816_RS05650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BK816_RS05660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BK816_RS05670	COG0772	Belongs to the SEDS family
BK816_RS05675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK816_RS05680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BK816_RS05685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BK816_RS05690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BK816_RS05695	COG0768	penicillin binding
BK816_RS05705	COG0275	rRNA processing
BK816_RS05710	COG2001	Belongs to the MraZ family
BK816_RS05720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK816_RS05735	COG3973	AAA domain
BK816_RS05740	COG0318	PFAM AMP-dependent synthetase and ligase
BK816_RS05745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BK816_RS05770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BK816_RS05780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BK816_RS05785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BK816_RS05790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK816_RS05795	COG1058	Belongs to the CinA family
BK816_RS05795	COG1546	Belongs to the CinA family
BK816_RS05800	COG2137	regulation of response to DNA damage stimulus
BK816_RS05805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BK816_RS05815	COG1396	sequence-specific DNA binding
BK816_RS05825	COG1674	ftsk spoiiie
BK816_RS05830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BK816_RS05830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BK816_RS05835	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BK816_RS05835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BK816_RS05855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BK816_RS05860	COG0612	Peptidase, M16
BK816_RS05865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BK816_RS05880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BK816_RS05885	COG1185	polyribonucleotide nucleotidyltransferase activity
BK816_RS05910	COG0439	Biotin carboxylase
BK816_RS05915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BK816_RS05925	COG0736	holo-[acyl-carrier-protein] synthase activity
BK816_RS05930	COG1268	BioY protein
BK816_RS05955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK816_RS05955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK816_RS05970	COG0779	Required for maturation of 30S ribosomal subunits
BK816_RS05990	COG1054	Belongs to the UPF0176 family
BK816_RS06000	COG0358	DNA primase activity
BK816_RS06025	COG0423	glycine-tRNA ligase activity
BK816_RS06030	COG3833	ABC-type maltose transport systems, permease component
BK816_RS06035	COG1175	transmembrane transport
BK816_RS06055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BK816_RS06065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BK816_RS06075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BK816_RS06085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BK816_RS06090	COG0484	heat shock protein binding
BK816_RS06095	COG1420	regulation of RNA biosynthetic process
BK816_RS06110	COG1121	(ABC) transporter
BK816_RS06115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK816_RS06130	COG0702	epimerase
BK816_RS06140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BK816_RS06145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BK816_RS06150	COG0481	GTPase activity
BK816_RS06160	COG0268	Binds directly to 16S ribosomal RNA
BK816_RS06170	COG0393	Putative heavy-metal-binding
BK816_RS06190	COG0433	COG0433 Predicted ATPase
BK816_RS06210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK816_RS06215	COG2095	MarC family integral membrane protein
BK816_RS06220	COG1252	NADH dehydrogenase
BK816_RS06260	COG0012	GTP binding
BK816_RS06270	COG0012	GTP binding
BK816_RS06275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK816_RS06285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BK816_RS06295	COG1722	exodeoxyribonuclease VII activity
BK816_RS06300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BK816_RS06305	COG1272	protein, Hemolysin III
BK816_RS06310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BK816_RS06345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BK816_RS06365	COG0148	phosphopyruvate hydratase activity
BK816_RS06375	COG0193	aminoacyl-tRNA hydrolase activity
BK816_RS06380	COG1126	abc transporter atp-binding protein
BK816_RS06385	COG0765	amino acid transport
BK816_RS06390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK816_RS06400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BK816_RS06415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BK816_RS06415	COG3291	Pkd domain containing protein
BK816_RS06450	COG2211	Major facilitator Superfamily
BK816_RS06460	COG1278	Cold shock
BK816_RS06465	COG0488	(ABC) transporter
BK816_RS06470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BK816_RS06485	COG0084	hydrolase, TatD family'
BK816_RS06495	COG0519	Catalyzes the synthesis of GMP from XMP
BK816_RS06495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BK816_RS06505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BK816_RS06525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BK816_RS06530	COG1611	Belongs to the LOG family
BK816_RS06535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK816_RS06545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK816_RS06555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BK816_RS06560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK816_RS06575	COG1079	Belongs to the binding-protein-dependent transport system permease family
BK816_RS06580	COG4603	Belongs to the binding-protein-dependent transport system permease family
BK816_RS06585	COG3845	ABC transporter
BK816_RS06590	COG1744	ABC transporter substrate-binding protein PnrA-like
BK816_RS06605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BK816_RS06645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BK816_RS06655	COG0395	ABC-type sugar transport system, permease component
BK816_RS06660	COG1175	transmembrane transport
BK816_RS06670	COG0039	L-malate dehydrogenase activity
BK816_RS06675	COG2326	polyphosphate kinase activity
BK816_RS06680	COG0166	Belongs to the GPI family
BK816_RS06705	COG0045	succinate-CoA ligase (ADP-forming) activity
BK816_RS06720	COG4721	ABC-type cobalt transport system, permease component
BK816_RS06725	COG4172	Belongs to the ABC transporter superfamily
BK816_RS06735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BK816_RS06735	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BK816_RS06740	COG2197	response regulator
BK816_RS06770	COG0028	Belongs to the TPP enzyme family
BK816_RS06775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK816_RS06780	COG1335	isochorismatase
BK816_RS06805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BK816_RS06810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BK816_RS06815	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BK816_RS06820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BK816_RS06855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BK816_RS06890	COG1140	nitrate reductase beta subunit
BK816_RS06910	COG0315	cyclic pyranopterin monophosphate synthase activity
BK816_RS06910	COG0521	Mo-molybdopterin cofactor biosynthetic process
BK816_RS06915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BK816_RS06940	COG0315	cyclic pyranopterin monophosphate synthase activity
BK816_RS06950	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BK816_RS06965	COG0133	tryptophan synthase activity
BK816_RS06975	COG0668	transmembrane transport
BK816_RS06980	COG0446	pyridine nucleotide-disulphide oxidoreductase
BK816_RS07030	COG0577	efflux transmembrane transporter activity
BK816_RS07030	COG1136	(ABC) transporter
BK816_RS07035	COG1136	(ABC) transporter
BK816_RS07035	COG0577	efflux transmembrane transporter activity
BK816_RS07125	COG4695	Portal protein
BK816_RS07145	COG1131	(ABC) transporter
BK816_RS07155	COG4626	Terminase
BK816_RS07155	COG1802	Transcriptional regulator
BK816_RS07180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BK816_RS07300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BK816_RS07320	COG3842	ATPase activity
BK816_RS07355	COG0191	fructose-bisphosphate aldolase activity
BK816_RS07360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK816_RS07365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BK816_RS07370	COG4221	oxidoreductase activity
BK816_RS07380	COG4166	transmembrane transport
BK816_RS07390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK816_RS07395	COG0395	ABC-type sugar transport system, permease component
BK816_RS07400	COG1175	transmembrane transport
BK816_RS07405	COG1653	transport
BK816_RS07415	COG0745	RESPONSE REGULATOR receiver
BK816_RS07420	COG2205	protein histidine kinase activity
BK816_RS07425	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BK816_RS07430	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BK816_RS07460	COG0789	Transcriptional regulator
BK816_RS07465	COG0484	heat shock protein binding
BK816_RS07470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BK816_RS07475	COG0443	Heat shock 70 kDa protein
BK816_RS07495	COG0569	domain protein
BK816_RS07495	COG2985	domain, Protein
BK816_RS07500	COG2226	methyltransferase
BK816_RS07510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK816_RS07515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BK816_RS07520	COG4948	Mandelate Racemase Muconate Lactonizing
BK816_RS07530	COG1361	Conserved repeat domain
BK816_RS07545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BK816_RS07565	COG1022	Amp-dependent synthetase and ligase
BK816_RS07580	COG0406	alpha-ribazole phosphatase activity
BK816_RS07595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BK816_RS07600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BK816_RS07605	COG0569	domain protein
BK816_RS07610	COG1316	TRANSCRIPTIONal
BK816_RS07620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BK816_RS07635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BK816_RS07645	COG0302	gtp cyclohydrolase
BK816_RS07650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK816_RS07660	COG0037	tRNA processing
BK816_RS07675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BK816_RS07680	COG0025	NhaP-type Na H and K H
BK816_RS07685	COG0791	NLP P60 protein
BK816_RS07745	COG1473	amidohydrolase
BK816_RS07750	COG2176	DNA-directed DNA polymerase activity
BK816_RS07760	COG1501	Belongs to the glycosyl hydrolase 31 family
BK816_RS07765	COG1609	Transcriptional regulator
BK816_RS07770	COG3119	arylsulfatase activity
BK816_RS07775	COG0395	ABC-type sugar transport system, permease component
BK816_RS07780	COG1175	transmembrane transport
BK816_RS07825	COG1136	(ABC) transporter
BK816_RS07845	COG0672	)-iron permease
BK816_RS07855	COG2837	iron assimilation
BK816_RS07870	COG0805	protein transport
BK816_RS07890	COG4604	ABC transporter, ATP-binding protein
BK816_RS07895	COG4605	iron ion homeostasis
BK816_RS07900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK816_RS07905	COG4607	ABC-type enterochelin transport system periplasmic component
BK816_RS07910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BK816_RS07925	COG1012	belongs to the aldehyde dehydrogenase family
BK816_RS07930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK816_RS07935	COG0745	RESPONSE REGULATOR receiver
BK816_RS07940	COG2205	protein histidine kinase activity
BK816_RS07965	COG0215	cysteine-tRNA ligase activity
BK816_RS07975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BK816_RS07995	COG0058	SHG alpha-glucan phosphorylase activity
BK816_RS08010	COG0450	alkyl hydroperoxide reductase
BK816_RS08015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BK816_RS08020	COG2855	membrane
BK816_RS08045	COG4221	oxidoreductase activity
BK816_RS08050	COG1233	COG1233 Phytoene dehydrogenase and related
BK816_RS08055	COG0386	Belongs to the glutathione peroxidase family
BK816_RS08060	COG1937	Protein conserved in bacteria
BK816_RS08070	COG1695	Transcriptional regulator
BK816_RS08135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BK816_RS08140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK816_RS08155	COG1309	transcriptional regulator
BK816_RS08160	COG4716	Myosin-crossreactive antigen
BK816_RS08195	COG0343	queuine tRNA-ribosyltransferase activity
BK816_RS08220	COG1754	DNA topoisomerase type I activity
BK816_RS08220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BK816_RS08225	COG2890	protein-(glutamine-N5) methyltransferase activity
BK816_RS08250	COG4172	Belongs to the ABC transporter superfamily
BK816_RS08255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK816_RS08260	COG0601	transmembrane transport
BK816_RS08280	COG0385	Bile acid
BK816_RS08285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BK816_RS08295	COG4152	abc transporter atp-binding protein
BK816_RS08305	COG3158	transport of potassium into the cell
BK816_RS08325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK816_RS08330	COG1464	Belongs to the NlpA lipoprotein family
BK816_RS08335	COG2011	ABC-type metal ion transport system permease component
BK816_RS08340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK816_RS08350	COG0726	polysaccharide deacetylase
BK816_RS08360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BK816_RS08360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BK816_RS08365	COG1329	Transcriptional regulator
BK816_RS08385	COG0588	phosphoglycerate mutase activity
BK816_RS08410	COG1476	TRANSCRIPTIONal
BK816_RS08420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BK816_RS08425	COG0512	Glutamine amidotransferase of anthranilate synthase
BK816_RS08430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BK816_RS08445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BK816_RS08495	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BK816_RS08495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK816_RS08540	COG1121	(ABC) transporter
BK816_RS08545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK816_RS08570	COG1511	domain protein
BK816_RS08585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BK816_RS08610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BK816_RS08625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK816_RS08650	COG2197	response regulator
BK816_RS08655	COG4585	Histidine kinase
BK816_RS08665	COG1131	(ABC) transporter
BK816_RS08670	COG1263	PTS System
BK816_RS08675	COG1115	amino acid carrier protein
BK816_RS08685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK816_RS08690	COG0328	RNA-DNA hybrid ribonuclease activity
BK816_RS08720	COG1643	Atp-dependent helicase
BK816_RS08760	COG0656	L-ascorbic acid biosynthetic process
BK816_RS08765	COG1902	pentaerythritol trinitrate reductase activity
BK816_RS08770	COG2116	formate transmembrane transporter activity
BK816_RS08775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BK816_RS08800	COG2814	Major facilitator Superfamily
BK816_RS08825	COG0586	Pfam SNARE associated Golgi protein
BK816_RS08835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BK816_RS08840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BK816_RS08855	COG0415	Belongs to the DNA photolyase family
BK816_RS08860	COG3142	Participates in the control of copper homeostasis
BK816_RS08885	COG0321	lipoyl(octanoyl) transferase activity
BK816_RS08890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BK816_RS08895	COG0318	PFAM AMP-dependent synthetase and ligase
BK816_RS08900	COG0360	Binds together with S18 to 16S ribosomal RNA
BK816_RS08910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BK816_RS08915	COG0359	binds to the 23S rRNA
BK816_RS08920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK816_RS08925	COG0617	tRNA 3'-terminal CCA addition
BK816_RS08930	COG1051	belongs to the nudix hydrolase family
BK816_RS08945	COG0492	ferredoxin-NADP+ reductase activity
BK816_RS08950	COG3118	belongs to the thioredoxin family
BK816_RS08955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK816_RS08960	COG1181	Belongs to the D-alanine--D-alanine ligase family
BK816_RS08970	COG1192	Involved in chromosome partitioning
BK816_RS08975	COG0357	Ribosomal RNA small subunit methyltransferase G
BK816_RS08985	COG0706	membrane insertase activity
BK816_RS08995	COG0594	ribonuclease P activity
BK816_RS09000	COG0230	Belongs to the bacterial ribosomal protein bL34 family