locus-tag	class	description
HRL51_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRL51_RS00010	COG0592	DNA-directed DNA polymerase activity
HRL51_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRL51_RS00025	COG0187	DNA topoisomerase II activity
HRL51_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRL51_RS00065	COG0656	L-ascorbic acid biosynthetic process
HRL51_RS00075	COG3764	Sortase (surface protein transpeptidase)
HRL51_RS00090	COG0515	serine threonine protein kinase
HRL51_RS00095	COG0768	penicillin binding
HRL51_RS00110	COG1716	ATPase activity
HRL51_RS00115	COG1716	ATPase activity
HRL51_RS00125	COG0535	radical SAM domain protein
HRL51_RS00130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HRL51_RS00135	COG0569	domain protein
HRL51_RS00135	COG2985	domain, Protein
HRL51_RS00140	COG2855	membrane
HRL51_RS00145	COG0450	alkyl hydroperoxide reductase
HRL51_RS00170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRL51_RS00180	COG1854	S-ribosylhomocysteine lyase activity
HRL51_RS00185	COG0596	Alpha beta hydrolase
HRL51_RS00190	COG0471	metal ion transport
HRL51_RS00195	COG3852	Histidine kinase
HRL51_RS00205	COG0628	permease
HRL51_RS00210	COG2390	Transcriptional regulator
HRL51_RS00215	COG1609	Transcriptional regulator
HRL51_RS00230	COG1175	transmembrane transport
HRL51_RS00235	COG0395	ABC-type sugar transport system, permease component
HRL51_RS00240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRL51_RS00245	COG1082	Xylose isomerase domain protein TIM barrel
HRL51_RS00250	COG3959	Transketolase, thiamine diphosphate binding domain
HRL51_RS00255	COG3958	Transketolase
HRL51_RS00265	COG2211	Major facilitator Superfamily
HRL51_RS00270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRL51_RS00275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRL51_RS00285	COG1113	amino acid transport
HRL51_RS00295	COG0156	8-amino-7-oxononanoate synthase activity
HRL51_RS00300	COG1063	alcohol dehydrogenase
HRL51_RS00305	COG0483	inositol monophosphate 1-phosphatase activity
HRL51_RS00320	COG1175	transmembrane transport
HRL51_RS00325	COG0395	ABC-type sugar transport system, permease component
HRL51_RS00345	COG1937	Protein conserved in bacteria
HRL51_RS00355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRL51_RS00365	COG1950	PFAM Membrane protein of
HRL51_RS00385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRL51_RS00435	COG2814	Major facilitator Superfamily
HRL51_RS00455	COG0077	Prephenate dehydratase
HRL51_RS00470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRL51_RS00475	COG0561	phosphatase activity
HRL51_RS00490	COG3833	ABC-type maltose transport systems, permease component
HRL51_RS00495	COG1175	transmembrane transport
HRL51_RS00505	COG1940	carbohydrate kinase activity
HRL51_RS00505	COG1846	Transcriptional regulator
HRL51_RS00545	COG0626	cystathionine gamma-synthase activity
HRL51_RS00550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRL51_RS00555	COG1132	(ABC) transporter
HRL51_RS00560	COG1132	(ABC) transporter
HRL51_RS00580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRL51_RS00585	COG2364	Membrane
HRL51_RS00600	COG2181	nitrate reductase activity
HRL51_RS00600	COG0247	lactate metabolic process
HRL51_RS00620	COG3842	ATPase activity
HRL51_RS00625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRL51_RS00630	COG0601	transmembrane transport
HRL51_RS00660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRL51_RS00680	COG1111	helicase
HRL51_RS00680	COG1205	dead DEAH box helicase
HRL51_RS00705	COG0443	Heat shock 70 kDa protein
HRL51_RS00710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRL51_RS00715	COG0484	heat shock protein binding
HRL51_RS00720	COG0789	Transcriptional regulator
HRL51_RS00725	COG0366	Alpha amylase catalytic
HRL51_RS00725	COG1470	cell adhesion involved in biofilm formation
HRL51_RS00735	COG1505	serine-type exopeptidase activity
HRL51_RS00760	COG0542	response to heat
HRL51_RS00775	COG0584	glycerophosphoryl diester phosphodiesterase
HRL51_RS00805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRL51_RS00810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRL51_RS00815	COG0215	cysteine-tRNA ligase activity
HRL51_RS00820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRL51_RS00835	COG3842	ATPase activity
HRL51_RS00855	COG4974	Belongs to the 'phage' integrase family
HRL51_RS00915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRL51_RS00925	COG0459	protein refolding
HRL51_RS00940	COG2205	protein histidine kinase activity
HRL51_RS00945	COG0745	RESPONSE REGULATOR receiver
HRL51_RS00955	COG1842	Phage shock protein A
HRL51_RS00965	COG0519	Catalyzes the synthesis of GMP from XMP
HRL51_RS00965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRL51_RS00970	COG1061	Type III restriction enzyme res subunit
HRL51_RS00985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRL51_RS00990	COG2252	PERMEase
HRL51_RS00995	COG2211	Major facilitator Superfamily
HRL51_RS01005	COG0791	NLP P60 protein
HRL51_RS01005	COG1388	LysM domain
HRL51_RS01005	COG3103	Sh3 type 3 domain protein
HRL51_RS01010	COG3103	Sh3 type 3 domain protein
HRL51_RS01010	COG1388	LysM domain
HRL51_RS01010	COG0791	NLP P60 protein
HRL51_RS01035	COG1970	mechanosensitive ion channel activity
HRL51_RS01045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRL51_RS01095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRL51_RS01100	COG0084	hydrolase, TatD family'
HRL51_RS01115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRL51_RS01120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRL51_RS01125	COG0488	(ABC) transporter
HRL51_RS01140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRL51_RS01165	COG0148	phosphopyruvate hydratase activity
HRL51_RS01190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRL51_RS01195	COG0193	aminoacyl-tRNA hydrolase activity
HRL51_RS01200	COG2197	response regulator
HRL51_RS01215	COG1131	(ABC) transporter
HRL51_RS01230	COG0129	dihydroxy-acid dehydratase activity
HRL51_RS01235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRL51_RS01240	COG0431	NADPH-dependent FMN reductase
HRL51_RS01250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRL51_RS01260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRL51_RS01270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRL51_RS01280	COG1722	exodeoxyribonuclease VII activity
HRL51_RS01285	COG1570	exodeoxyribonuclease VII activity
HRL51_RS01295	COG1322	Protein conserved in bacteria
HRL51_RS01305	COG0012	GTP binding
HRL51_RS01355	COG1362	aminopeptidase activity
HRL51_RS01360	COG3012	SEC-C Motif Domain Protein
HRL51_RS01365	COG1902	pentaerythritol trinitrate reductase activity
HRL51_RS01370	COG4667	esterase of the alpha-beta hydrolase superfamily
HRL51_RS01385	COG2267	carboxylic ester hydrolase activity
HRL51_RS01390	COG1268	BioY protein
HRL51_RS01400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRL51_RS01430	COG1217	gtp-binding protein TYPA
HRL51_RS01435	COG2720	vancomycin resistance protein
HRL51_RS01465	COG2171	N-acyltransferase activity
HRL51_RS01470	COG0406	alpha-ribazole phosphatase activity
HRL51_RS01495	COG3477	response to acidic pH
HRL51_RS01520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRL51_RS01525	COG2235	arginine
HRL51_RS01535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRL51_RS01540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRL51_RS01545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRL51_RS01550	COG0395	ABC-type sugar transport system, permease component
HRL51_RS01555	COG1175	transmembrane transport
HRL51_RS01565	COG5426	von Willebrand factor, type A
HRL51_RS01575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRL51_RS01580	COG4948	Mandelate Racemase Muconate Lactonizing
HRL51_RS01585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRL51_RS01590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRL51_RS01595	COG1169	isochorismate synthase
HRL51_RS01600	COG2226	methyltransferase
HRL51_RS01610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRL51_RS01615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRL51_RS01620	COG0649	NAD binding
HRL51_RS01630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HRL51_RS01635	COG1034	ATP synthesis coupled electron transport
HRL51_RS01640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRL51_RS01645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRL51_RS01655	COG0713	ATP synthesis coupled electron transport
HRL51_RS01660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRL51_RS01670	COG1007	ATP synthesis coupled electron transport
HRL51_RS01675	COG0142	geranyltranstransferase activity
HRL51_RS01685	COG0501	Belongs to the peptidase M48B family
HRL51_RS01690	COG1666	GTP binding
HRL51_RS01725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRL51_RS01730	COG0424	maF-like protein
HRL51_RS01745	COG0745	RESPONSE REGULATOR receiver
HRL51_RS01750	COG5002	protein histidine kinase activity
HRL51_RS01775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRL51_RS01780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRL51_RS01785	COG1316	TRANSCRIPTIONal
HRL51_RS01790	COG1316	TRANSCRIPTIONal
HRL51_RS01810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRL51_RS01820	COG0673	inositol 2-dehydrogenase activity
HRL51_RS01845	COG0367	asparagine synthase
HRL51_RS01865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRL51_RS01880	COG0791	NLP P60 protein
HRL51_RS01880	COG3883	PFAM NLP P60 protein
HRL51_RS01885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRL51_RS01895	COG1088	dTDP-glucose 4,6-dehydratase activity
HRL51_RS01940	COG0438	transferase activity, transferring glycosyl groups
HRL51_RS01960	COG0697	spore germination
HRL51_RS01970	COG0438	transferase activity, transferring glycosyl groups
HRL51_RS01980	COG3475	LICD family
HRL51_RS01985	COG3475	LICD family
HRL51_RS02000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRL51_RS02005	COG1482	cell wall glycoprotein biosynthetic process
HRL51_RS02020	COG4981	capsule polysaccharide biosynthetic process
HRL51_RS02040	COG2835	tetraacyldisaccharide 4'-kinase activity
HRL51_RS02055	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HRL51_RS02060	COG0714	Associated with various cellular activities
HRL51_RS02080	COG0745	RESPONSE REGULATOR receiver
HRL51_RS02085	COG5000	phosphorelay sensor kinase activity
HRL51_RS02085	COG5002	protein histidine kinase activity
HRL51_RS02090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRL51_RS02100	COG0653	protein targeting
HRL51_RS02130	COG0419	ATPase involved in DNA repair
HRL51_RS02135	COG0420	3'-5' exonuclease activity
HRL51_RS02145	COG4115	mRNA cleavage
HRL51_RS02225	COG1968	undecaprenyl-diphosphatase activity
HRL51_RS02230	COG0483	inositol monophosphate 1-phosphatase activity
HRL51_RS02255	COG1140	nitrate reductase beta subunit
HRL51_RS02270	COG1546	Belongs to the CinA family
HRL51_RS02270	COG1058	Belongs to the CinA family
HRL51_RS02280	COG0315	cyclic pyranopterin monophosphate synthase activity
HRL51_RS02300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRL51_RS02330	COG1162	GTPase activity
HRL51_RS02335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRL51_RS02340	COG2838	Isocitrate dehydrogenase
HRL51_RS02350	COG1595	DNA-templated transcription, initiation
HRL51_RS02355	COG5662	AntiSigma factor
HRL51_RS02365	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRL51_RS02365	COG0567	Dehydrogenase, E1 component
HRL51_RS02370	COG1253	flavin adenine dinucleotide binding
HRL51_RS02380	COG1196	nuclear chromosome segregation
HRL51_RS02380	COG0741	lytic transglycosylase activity
HRL51_RS02380	COG0739	heme binding
HRL51_RS02390	COG2272	Belongs to the type-B carboxylesterase lipase family
HRL51_RS02405	COG0018	arginyl-trna synthetase
HRL51_RS02410	COG0019	diaminopimelate decarboxylase activity
HRL51_RS02415	COG0460	homoserine dehydrogenase
HRL51_RS02420	COG0083	homoserine kinase activity
HRL51_RS02435	COG0254	rRNA binding
HRL51_RS02440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRL51_RS02450	COG1136	(ABC) transporter
HRL51_RS02450	COG0577	efflux transmembrane transporter activity
HRL51_RS02465	COG0395	ABC-type sugar transport system, permease component
HRL51_RS02470	COG1175	transmembrane transport
HRL51_RS02480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRL51_RS02480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRL51_RS02490	COG1486	melibiose metabolic process
HRL51_RS02500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HRL51_RS02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRL51_RS02525	COG1349	DNA-binding transcription factor activity
HRL51_RS02570	COG1609	Transcriptional regulator
HRL51_RS02575	COG1028	Short-chain dehydrogenase reductase Sdr
HRL51_RS02580	COG1501	Belongs to the glycosyl hydrolase 31 family
HRL51_RS02585	COG1609	Transcriptional regulator
HRL51_RS02595	COG0366	Alpha amylase catalytic
HRL51_RS02615	COG0205	6-phosphofructokinase activity
HRL51_RS02620	COG0045	succinate-CoA ligase (ADP-forming) activity
HRL51_RS02670	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRL51_RS02675	COG0039	L-malate dehydrogenase activity
HRL51_RS02685	COG1175	transmembrane transport
HRL51_RS02690	COG0395	ABC-type sugar transport system, permease component
HRL51_RS02730	COG0058	SHG alpha-glucan phosphorylase activity
HRL51_RS02735	COG3119	arylsulfatase activity
HRL51_RS02740	COG1609	Transcriptional regulator
HRL51_RS02745	COG2271	Major facilitator Superfamily
HRL51_RS02750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRL51_RS02755	COG3281	Trehalose synthase
HRL51_RS02760	COG0366	Alpha amylase catalytic
HRL51_RS02775	COG2086	electron transfer activity
HRL51_RS02780	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRL51_RS02790	COG1609	Transcriptional regulator
HRL51_RS02800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRL51_RS02805	COG1131	(ABC) transporter
HRL51_RS02815	COG0482	sulfurtransferase activity
HRL51_RS02840	COG3480	Lon protease (S16) C-terminal proteolytic domain
HRL51_RS02855	COG1615	UPF0182 protein
HRL51_RS03105	COG1192	Involved in chromosome partitioning
HRL51_RS03145	COG1733	regulation of RNA biosynthetic process
HRL51_RS03165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRL51_RS03165	COG2111	Na H antiporter
HRL51_RS03170	COG1006	Multisubunit Na H antiporter MnhC subunit
HRL51_RS03175	COG0651	ATP synthesis coupled electron transport
HRL51_RS03190	COG1320	monovalent cation:proton antiporter activity
HRL51_RS03205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRL51_RS03210	COG0114	fumarate hydratase activity
HRL51_RS03235	COG1609	Transcriptional regulator
HRL51_RS03240	COG0673	inositol 2-dehydrogenase activity
HRL51_RS03250	COG2814	Major facilitator Superfamily
HRL51_RS03260	COG1609	Transcriptional regulator
HRL51_RS03265	COG2814	Major facilitator Superfamily
HRL51_RS03275	COG0673	inositol 2-dehydrogenase activity
HRL51_RS03285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HRL51_RS03315	COG1674	ftsk spoiiie
HRL51_RS03325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRL51_RS03335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRL51_RS03340	COG0154	amidase activity
HRL51_RS03345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRL51_RS03375	COG2985	domain, Protein
HRL51_RS03375	COG0569	domain protein
HRL51_RS03385	COG0440	acetolactate synthase activity
HRL51_RS03390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRL51_RS03395	COG0473	3-isopropylmalate dehydrogenase activity
HRL51_RS03400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRL51_RS03405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRL51_RS03685	COG0582	viral genome integration into host DNA
HRL51_RS03695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRL51_RS03835	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HRL51_RS03845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRL51_RS03850	COG0629	single-stranded DNA binding
HRL51_RS03860	COG2884	Cell division ATP-binding protein ftsE
HRL51_RS03865	COG2177	Part of the ABC transporter FtsEX involved in
HRL51_RS03870	COG0739	heme binding
HRL51_RS03915	COG0667	Aldo Keto reductase
HRL51_RS03920	COG2233	PERMEase
HRL51_RS03925	COG0657	acetylesterase activity
HRL51_RS03930	COG2186	Transcriptional regulator
HRL51_RS03935	COG0747	negative chemotaxis
HRL51_RS03945	COG0444	Belongs to the ABC transporter superfamily
HRL51_RS03950	COG4608	Belongs to the ABC transporter superfamily
HRL51_RS03955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRL51_RS03960	COG1940	carbohydrate kinase activity
HRL51_RS03965	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HRL51_RS03985	COG0363	glucosamine-6-phosphate deaminase activity
HRL51_RS04005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRL51_RS04015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRL51_RS04020	COG1234	tRNA 3'-trailer cleavage
HRL51_RS04035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRL51_RS04040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRL51_RS04085	COG3304	Inner membrane component domain
HRL51_RS04090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRL51_RS04095	COG3250	beta-galactosidase activity
HRL51_RS04120	COG0747	negative chemotaxis
HRL51_RS04125	COG0601	transmembrane transport
HRL51_RS04135	COG4172	Belongs to the ABC transporter superfamily
HRL51_RS04140	COG3250	beta-galactosidase activity
HRL51_RS04165	COG3507	Belongs to the glycosyl hydrolase 43 family
HRL51_RS04170	COG3250	beta-galactosidase activity
HRL51_RS04175	COG1309	transcriptional regulator
HRL51_RS04185	COG2723	6-phospho-beta-galactosidase activity
HRL51_RS04215	COG1070	Carbohydrate kinase
HRL51_RS04225	COG2814	Major facilitator Superfamily
HRL51_RS04230	COG1609	Transcriptional regulator
HRL51_RS04240	COG1115	amino acid carrier protein
HRL51_RS04245	COG1115	amino acid carrier protein
HRL51_RS04250	COG1115	amino acid carrier protein
HRL51_RS04255	COG1115	amino acid carrier protein
HRL51_RS04270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRL51_RS04295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HRL51_RS04305	COG1674	ftsk spoiiie
HRL51_RS04320	COG1546	Belongs to the CinA family
HRL51_RS04320	COG1058	Belongs to the CinA family
HRL51_RS04325	COG1396	sequence-specific DNA binding
HRL51_RS04335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRL51_RS04345	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRL51_RS04350	COG0509	glycine decarboxylation via glycine cleavage system
HRL51_RS04355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRL51_RS04360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRL51_RS04360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRL51_RS04370	COG0395	ABC-type sugar transport system, permease component
HRL51_RS04385	COG1846	Transcriptional regulator
HRL51_RS04385	COG1940	carbohydrate kinase activity
HRL51_RS04390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRL51_RS04395	COG1683	Conserved Protein
HRL51_RS04430	COG2197	response regulator
HRL51_RS04450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRL51_RS04455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRL51_RS04460	COG1114	Component of the transport system for branched-chain amino acids
HRL51_RS04480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRL51_RS04495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRL51_RS04505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRL51_RS04510	COG0438	transferase activity, transferring glycosyl groups
HRL51_RS04530	COG0066	3-isopropylmalate dehydratase activity
HRL51_RS04555	COG3119	arylsulfatase activity
HRL51_RS04560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRL51_RS04565	COG0204	Acyl-transferase
HRL51_RS04570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRL51_RS04580	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRL51_RS04590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRL51_RS04595	COG1461	Dihydroxyacetone kinase
HRL51_RS04605	COG0641	radical SAM
HRL51_RS04610	COG0730	response to heat
HRL51_RS04615	COG1940	carbohydrate kinase activity
HRL51_RS04625	COG0742	ribosomal rna small subunit methyltransferase
HRL51_RS04650	COG0571	ribonuclease III activity
HRL51_RS04655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRL51_RS04670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HRL51_RS04675	COG4988	ABC transporter
HRL51_RS04680	COG1294	oxidase, subunit
HRL51_RS04685	COG1271	oxidase subunit
HRL51_RS04690	COG1530	ribonuclease E activity
HRL51_RS04695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRL51_RS04700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRL51_RS04705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRL51_RS04710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRL51_RS04715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRL51_RS04720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRL51_RS04730	COG0799	negative regulation of ribosome biogenesis
HRL51_RS04735	COG0588	phosphoglycerate mutase activity
HRL51_RS04750	COG3226	Transcriptional regulator
HRL51_RS04765	COG0243	molybdopterin cofactor binding
HRL51_RS04780	COG1064	alcohol dehydrogenase
HRL51_RS04790	COG0733	neurotransmitter:sodium symporter activity
HRL51_RS04825	COG0495	leucyl-tRNA aminoacylation
HRL51_RS04835	COG0433	COG0433 Predicted ATPase
HRL51_RS04840	COG1307	EDD domain protein, DegV family
HRL51_RS04860	COG4868	Belongs to the UPF0371 family
HRL51_RS04875	COG0268	Binds directly to 16S ribosomal RNA
HRL51_RS04885	COG0159	tryptophan synthase activity
HRL51_RS04895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRL51_RS04900	COG0512	Glutamine amidotransferase of anthranilate synthase
HRL51_RS04905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRL51_RS04915	COG0481	GTPase activity
HRL51_RS04920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRL51_RS04925	COG2807	transmembrane transport
HRL51_RS04950	COG1420	regulation of RNA biosynthetic process
HRL51_RS04955	COG0484	heat shock protein binding
HRL51_RS04965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRL51_RS05025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRL51_RS05055	COG1309	transcriptional regulator
HRL51_RS05075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRL51_RS05085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRL51_RS05095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRL51_RS05095	COG0506	proline dehydrogenase activity
HRL51_RS05095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRL51_RS05100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRL51_RS05115	COG1381	Involved in DNA repair and RecF pathway recombination
HRL51_RS05120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRL51_RS05130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRL51_RS05145	COG0423	glycine-tRNA ligase activity
HRL51_RS05155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRL51_RS05165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRL51_RS05180	COG0560	Phosphoserine phosphatase
HRL51_RS05190	COG0297	glycogen (starch) synthase activity
HRL51_RS05200	COG1119	ATPase activity
HRL51_RS05240	COG0488	(ABC) transporter
HRL51_RS05255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRL51_RS05275	COG0205	6-phosphofructokinase activity
HRL51_RS05280	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRL51_RS05285	COG2815	serine threonine protein kinase
HRL51_RS05285	COG0515	serine threonine protein kinase
HRL51_RS05290	COG0142	geranyltranstransferase activity
HRL51_RS05295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRL51_RS05320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRL51_RS05365	COG0569	domain protein
HRL51_RS05370	COG0531	amino acid
HRL51_RS05375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRL51_RS05380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRL51_RS05390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRL51_RS05395	COG4221	oxidoreductase activity
HRL51_RS05400	COG1881	PFAM PEBP family protein
HRL51_RS05415	COG1846	Transcriptional regulator
HRL51_RS05415	COG1940	carbohydrate kinase activity
HRL51_RS05425	COG1175	transmembrane transport
HRL51_RS05430	COG0395	ABC-type sugar transport system, permease component
HRL51_RS05440	COG3119	arylsulfatase activity
HRL51_RS05445	COG0671	phosphoesterase, PA-phosphatase related
HRL51_RS05450	COG1435	thymidine kinase activity
HRL51_RS05455	COG0833	amino acid
HRL51_RS05460	COG0587	DNA-directed DNA polymerase activity
HRL51_RS05475	COG0676	glucose-6-phosphate 1-epimerase activity
HRL51_RS05485	COG0738	Major facilitator superfamily
HRL51_RS05505	COG1136	(ABC) transporter
HRL51_RS05510	COG0339	signal peptide processing
HRL51_RS05530	COG1609	Transcriptional regulator
HRL51_RS05535	COG0483	inositol monophosphate 1-phosphatase activity
HRL51_RS05545	COG0667	Aldo Keto reductase
HRL51_RS05555	COG1994	Peptidase M50
HRL51_RS05555	COG0517	IMP dehydrogenase activity
HRL51_RS05565	COG1222	aaa ATPase
HRL51_RS05570	COG4122	O-methyltransferase activity
HRL51_RS05580	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HRL51_RS05595	COG0107	imidazoleglycerol-phosphate synthase activity
HRL51_RS05600	COG0134	indole-3-glycerol-phosphate synthase activity
HRL51_RS05635	COG0539	negative regulation of cytoplasmic translation
HRL51_RS05640	COG2076	Multidrug Resistance protein
HRL51_RS05645	COG0237	dephospho-CoA kinase activity
HRL51_RS05655	COG0556	nucleotide-excision repair
HRL51_RS05715	COG0322	excinuclease ABC activity
HRL51_RS05720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRL51_RS05725	COG1660	Displays ATPase and GTPase activities
HRL51_RS05730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRL51_RS05735	COG1481	regulation of sporulation
HRL51_RS05740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRL51_RS05750	COG0149	triose-phosphate isomerase activity
HRL51_RS05755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRL51_RS05770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HRL51_RS05775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRL51_RS05790	COG1160	GTP binding
HRL51_RS05795	COG0166	Belongs to the GPI family
HRL51_RS05800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRL51_RS05850	COG4989	oxidoreductase activity
HRL51_RS05865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRL51_RS05875	COG1716	ATPase activity
HRL51_RS05905	COG1621	beta-fructofuranosidase activity
HRL51_RS05910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRL51_RS05910	COG2190	(PTS) system
HRL51_RS05910	COG1263	PTS System
HRL51_RS05915	COG1609	Transcriptional regulator
HRL51_RS05930	COG0205	6-phosphofructokinase activity
HRL51_RS05940	COG1216	Glycosyl transferase, family 2
HRL51_RS05950	COG2354	Protein conserved in bacteria
HRL51_RS05955	COG4581	dead DEAH box helicase
HRL51_RS05965	COG0805	protein transport
HRL51_RS05970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRL51_RS05980	COG2378	regulation of single-species biofilm formation
HRL51_RS05990	COG0140	phosphoribosyl-ATP diphosphatase activity
HRL51_RS05995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRL51_RS06000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRL51_RS06005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRL51_RS06010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRL51_RS06015	COG0736	holo-[acyl-carrier-protein] synthase activity
HRL51_RS06020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRL51_RS06020	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HRL51_RS06020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRL51_RS06025	COG1461	Dihydroxyacetone kinase
HRL51_RS06030	COG2376	Dihydroxyacetone kinase
HRL51_RS06035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRL51_RS06040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRL51_RS06045	COG4770	biotin carboxylase activity
HRL51_RS06055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRL51_RS06065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRL51_RS06085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRL51_RS06095	COG1758	RNA polymerase activity
HRL51_RS06100	COG0194	GDP metabolic process
HRL51_RS06105	COG0284	orotidine-5'-phosphate decarboxylase activity
HRL51_RS06110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRL51_RS06120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRL51_RS06125	COG0540	Belongs to the ATCase OTCase family
HRL51_RS06130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRL51_RS06140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRL51_RS06145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRL51_RS06150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRL51_RS06160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRL51_RS06165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRL51_RS06175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRL51_RS06185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRL51_RS06190	COG0730	response to heat
HRL51_RS06200	COG2409	Drug exporters of the RND superfamily
HRL51_RS06205	COG0009	L-threonylcarbamoyladenylate synthase
HRL51_RS06210	COG1136	(ABC) transporter
HRL51_RS06225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRL51_RS06245	COG1162	GTPase activity
HRL51_RS06275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRL51_RS06285	COG0437	4 iron, 4 sulfur cluster binding
HRL51_RS06290	COG0243	molybdopterin cofactor binding
HRL51_RS06290	COG3383	formate dehydrogenase (NAD+) activity
HRL51_RS06295	COG1196	nuclear chromosome segregation
HRL51_RS06305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRL51_RS06310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRL51_RS06315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRL51_RS06320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRL51_RS06330	COG2255	four-way junction helicase activity
HRL51_RS06335	COG0632	four-way junction helicase activity
HRL51_RS06340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRL51_RS06345	COG0217	transcriptional regulatory protein
HRL51_RS06350	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HRL51_RS06355	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HRL51_RS06360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRL51_RS06375	COG0438	transferase activity, transferring glycosyl groups
HRL51_RS06380	COG1560	Kdo2-lipid A biosynthetic process
HRL51_RS06395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRL51_RS06435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRL51_RS06455	COG1882	Formate acetyltransferase
HRL51_RS06470	COG0038	chloride channel
HRL51_RS06475	COG1131	(ABC) transporter
HRL51_RS06495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRL51_RS06500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRL51_RS06505	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRL51_RS06525	COG0321	lipoyl(octanoyl) transferase activity
HRL51_RS06530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRL51_RS06550	COG0765	amino acid transport
HRL51_RS06565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRL51_RS06570	COG0174	glutamine synthetase
HRL51_RS06575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRL51_RS06595	COG3022	response to hydroperoxide
HRL51_RS06605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRL51_RS06620	COG0346	lactoylglutathione lyase activity
HRL51_RS06635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRL51_RS06640	COG1027	Aspartate ammonia-lyase
HRL51_RS06655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRL51_RS06685	COG0358	DNA primase activity
HRL51_RS06690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HRL51_RS06715	COG2856	Zn peptidase
HRL51_RS06965	COG1929	Belongs to the glycerate kinase type-1 family
HRL51_RS06980	COG0667	Aldo Keto reductase
HRL51_RS06990	COG0167	dihydroorotate dehydrogenase activity
HRL51_RS06995	COG3189	MarR family transcriptional regulator
HRL51_RS07000	COG2151	metal-sulfur cluster biosynthetic enzyme
HRL51_RS07005	COG0822	iron-sulfur transferase activity
HRL51_RS07015	COG0396	ATPase activity
HRL51_RS07045	COG1609	Transcriptional regulator
HRL51_RS07050	COG0395	ABC-type sugar transport system, permease component
HRL51_RS07055	COG1175	transmembrane transport
HRL51_RS07060	COG1653	transport
HRL51_RS07080	COG1175	transmembrane transport
HRL51_RS07090	COG1609	Transcriptional regulator
HRL51_RS07100	COG0504	CTP synthase activity
HRL51_RS07105	COG0438	transferase activity, transferring glycosyl groups
HRL51_RS07130	COG0497	DNA recombination
HRL51_RS07150	COG0647	UMP catabolic process
HRL51_RS07175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRL51_RS07180	COG2094	Belongs to the DNA glycosylase MPG family
HRL51_RS07185	COG0165	Argininosuccinate lyase
HRL51_RS07190	COG0137	argininosuccinate synthase activity
HRL51_RS07195	COG1438	arginine binding
HRL51_RS07200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRL51_RS07205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRL51_RS07215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRL51_RS07230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRL51_RS07235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HRL51_RS07245	COG0395	ABC-type sugar transport system, permease component
HRL51_RS07250	COG1175	transmembrane transport
HRL51_RS07255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRL51_RS07260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRL51_RS07265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRL51_RS07270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRL51_RS07280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRL51_RS07285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRL51_RS07295	COG0131	Imidazoleglycerol-phosphate dehydratase
HRL51_RS07305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRL51_RS07310	COG0514	ATP-dependent DNA helicase (RecQ)
HRL51_RS07315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRL51_RS07335	COG0714	Associated with various cellular activities
HRL51_RS07350	COG1501	Belongs to the glycosyl hydrolase 31 family
HRL51_RS07355	COG0395	ABC-type sugar transport system, permease component
HRL51_RS07360	COG4209	transmembrane transport
HRL51_RS07380	COG0531	amino acid
HRL51_RS07390	COG3250	beta-galactosidase activity
HRL51_RS07395	COG1609	Transcriptional regulator
HRL51_RS07420	COG2501	S4 domain
HRL51_RS07425	COG0587	DNA-directed DNA polymerase activity
HRL51_RS07440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRL51_RS07445	COG3599	regulation of cell shape
HRL51_RS07455	COG1799	cell septum assembly
HRL51_RS07460	COG1496	oxidoreductase activity
HRL51_RS07475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRL51_RS07490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRL51_RS07495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRL51_RS07500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRL51_RS07505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRL51_RS07510	COG0768	penicillin binding
HRL51_RS07520	COG0275	rRNA processing
HRL51_RS07525	COG2001	Belongs to the MraZ family
HRL51_RS07535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRL51_RS07560	COG0318	PFAM AMP-dependent synthetase and ligase
HRL51_RS07565	COG0318	PFAM AMP-dependent synthetase and ligase
HRL51_RS07570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRL51_RS07580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRL51_RS07585	COG0612	Peptidase, M16
HRL51_RS07590	COG1185	polyribonucleotide nucleotidyltransferase activity
HRL51_RS07600	COG0196	riboflavin kinase activity
HRL51_RS07610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRL51_RS07615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRL51_RS07630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRL51_RS07630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRL51_RS07645	COG0779	Required for maturation of 30S ribosomal subunits
HRL51_RS07660	COG0442	prolyl-tRNA aminoacylation
HRL51_RS07675	COG0454	-acetyltransferase
HRL51_RS07675	COG0456	acetyltransferase
HRL51_RS07680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRL51_RS07690	COG0750	zinc metalloprotease
HRL51_RS07695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRL51_RS07705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRL51_RS07710	COG0575	Belongs to the CDS family
HRL51_RS07715	COG0233	cytoplasmic translational termination
HRL51_RS07730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRL51_RS07735	COG0052	Belongs to the universal ribosomal protein uS2 family
HRL51_RS07745	COG4974	Belongs to the 'phage' integrase family
HRL51_RS07760	COG0792	nuclease activity
HRL51_RS07770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRL51_RS07775	COG0681	Belongs to the peptidase S26 family
HRL51_RS07790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRL51_RS07795	COG1837	Belongs to the UPF0109 family
HRL51_RS07810	COG1131	(ABC) transporter
HRL51_RS07820	COG1115	amino acid carrier protein
HRL51_RS07825	COG1131	(ABC) transporter
HRL51_RS07835	COG4585	Histidine kinase
HRL51_RS07840	COG2197	response regulator
HRL51_RS07870	COG1196	nuclear chromosome segregation
HRL51_RS07880	COG4152	abc transporter atp-binding protein
HRL51_RS07890	COG0105	UTP biosynthetic process
HRL51_RS07895	COG1461	Dihydroxyacetone kinase
HRL51_RS07900	COG0285	dihydrofolate synthase activity
HRL51_RS07910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRL51_RS07930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRL51_RS07935	COG1940	carbohydrate kinase activity
HRL51_RS07945	COG1175	transmembrane transport
HRL51_RS07950	COG0395	ABC-type sugar transport system, permease component
HRL51_RS08000	COG1605	Chorismate mutase
HRL51_RS08000	COG0287	Prephenate dehydrogenase
HRL51_RS08005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRL51_RS08010	COG0740	serine-type endopeptidase activity
HRL51_RS08030	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRL51_RS08130	COG1739	Uncharacterized protein family UPF0029
HRL51_RS08140	COG1045	serine acetyltransferase
HRL51_RS08155	COG0698	ribose 5-phosphate isomerase
HRL51_RS08160	COG3590	peptidase
HRL51_RS08165	COG1929	Belongs to the glycerate kinase type-1 family
HRL51_RS08175	COG1263	PTS System
HRL51_RS08180	COG2188	Transcriptional regulator
HRL51_RS08185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRL51_RS08185	COG1263	PTS System
HRL51_RS08190	COG2190	(PTS) system
HRL51_RS08200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRL51_RS08205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRL51_RS08220	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HRL51_RS08265	COG0513	Belongs to the DEAD box helicase family
HRL51_RS08270	COG2095	MarC family integral membrane protein
HRL51_RS08280	COG0006	proline dipeptidase activity
HRL51_RS08285	COG1230	cation diffusion facilitator family transporter
HRL51_RS08290	COG1082	Xylose isomerase domain protein TIM barrel
HRL51_RS08300	COG2239	Acts as a magnesium transporter
HRL51_RS08310	COG2755	lipolytic protein G-D-S-L family
HRL51_RS08310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRL51_RS08315	COG0489	protein tyrosine kinase activity
HRL51_RS08315	COG2151	metal-sulfur cluster biosynthetic enzyme
HRL51_RS08325	COG4122	O-methyltransferase activity
HRL51_RS08335	COG1611	Belongs to the LOG family
HRL51_RS08350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRL51_RS08365	COG1121	(ABC) transporter
HRL51_RS08375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRL51_RS08380	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRL51_RS08395	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRL51_RS08400	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRL51_RS08405	COG3845	ABC transporter
HRL51_RS08410	COG1744	ABC transporter substrate-binding protein PnrA-like
HRL51_RS08415	COG0662	Cupin 2, conserved barrel domain protein
HRL51_RS08415	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HRL51_RS08425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRL51_RS08435	COG1136	(ABC) transporter
HRL51_RS08435	COG0577	efflux transmembrane transporter activity
HRL51_RS08440	COG1136	(ABC) transporter
HRL51_RS08440	COG0577	efflux transmembrane transporter activity
HRL51_RS08450	COG0708	Exodeoxyribonuclease III
HRL51_RS08455	COG0549	Belongs to the carbamate kinase family
HRL51_RS08460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRL51_RS08465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRL51_RS08480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRL51_RS08490	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HRL51_RS08495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRL51_RS08515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRL51_RS08525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRL51_RS08530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRL51_RS08535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRL51_RS08540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRL51_RS08545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRL51_RS08550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRL51_RS08555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRL51_RS08560	COG0356	it plays a direct role in the translocation of protons across the membrane
HRL51_RS08570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRL51_RS08580	COG2197	response regulator
HRL51_RS08600	COG0656	L-ascorbic acid biosynthetic process
HRL51_RS08610	COG0577	efflux transmembrane transporter activity
HRL51_RS08610	COG1136	(ABC) transporter
HRL51_RS08625	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRL51_RS08635	COG0667	Aldo Keto reductase
HRL51_RS08640	COG0789	Transcriptional regulator
HRL51_RS08650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRL51_RS08650	COG0519	Catalyzes the synthesis of GMP from XMP
HRL51_RS08675	COG0673	inositol 2-dehydrogenase activity
HRL51_RS08680	COG2814	Major facilitator Superfamily
HRL51_RS08695	COG2814	Major facilitator Superfamily
HRL51_RS08710	COG0673	inositol 2-dehydrogenase activity
HRL51_RS08715	COG2814	Major facilitator Superfamily
HRL51_RS08720	COG1082	Xylose isomerase domain protein TIM barrel
HRL51_RS08725	COG0673	inositol 2-dehydrogenase activity
HRL51_RS08735	COG0577	efflux transmembrane transporter activity
HRL51_RS08735	COG1136	(ABC) transporter
HRL51_RS08765	COG3718	enzyme involved in inositol metabolism
HRL51_RS08780	COG2188	Transcriptional regulator
HRL51_RS08785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRL51_RS08790	COG0673	inositol 2-dehydrogenase activity
HRL51_RS08805	COG1082	Xylose isomerase domain protein TIM barrel
HRL51_RS08810	COG1609	Transcriptional regulator
HRL51_RS08825	COG0328	RNA-DNA hybrid ribonuclease activity
HRL51_RS08830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRL51_RS08835	COG0516	GMP reductase activity
HRL51_RS08855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRL51_RS08865	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HRL51_RS08870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRL51_RS08875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRL51_RS08880	COG1053	succinate dehydrogenase
HRL51_RS08900	COG0802	atpase or kinase
HRL51_RS08905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRL51_RS08910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRL51_RS08910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRL51_RS08915	COG0736	holo-[acyl-carrier-protein] synthase activity
HRL51_RS08925	COG1072	(Pantothenic acid kinase))
HRL51_RS08945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRL51_RS08950	COG0101	tRNA pseudouridine synthase activity
HRL51_RS08955	COG1285	pathogenesis
HRL51_RS08960	COG1609	Transcriptional regulator
HRL51_RS08970	COG1178	ABC-type Fe3 transport system permease component
HRL51_RS08975	COG3842	ATPase activity
HRL51_RS08980	COG1840	ABC-type Fe3 transport system, periplasmic component
HRL51_RS08990	COG0203	ribosomal protein L17
HRL51_RS08995	COG0202	RNA polymerase activity
HRL51_RS09000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRL51_RS09005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRL51_RS09010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRL51_RS09015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRL51_RS09025	COG0563	adenylate kinase activity
HRL51_RS09040	COG1841	ribosomal large subunit assembly
HRL51_RS09045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRL51_RS09050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRL51_RS09055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRL51_RS09065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRL51_RS09070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRL51_RS09075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRL51_RS09080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRL51_RS09085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRL51_RS09090	COG0255	Belongs to the universal ribosomal protein uL29 family
HRL51_RS09095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRL51_RS09100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRL51_RS09105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRL51_RS09110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRL51_RS09115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRL51_RS09120	COG0089	rRNA binding
HRL51_RS09135	COG0051	transcription antitermination factor activity, RNA binding
HRL51_RS09145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRL51_RS09150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRL51_RS09155	COG0049	tRNA binding
HRL51_RS09160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRL51_RS09165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRL51_RS09170	COG1121	(ABC) transporter
HRL51_RS09180	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRL51_RS09190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRL51_RS09195	COG0085	RNA polymerase activity
HRL51_RS09200	COG0222	ribosome binding
HRL51_RS09205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRL51_RS09220	COG0081	regulation of translation
HRL51_RS09225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRL51_RS09230	COG0250	Participates in transcription elongation, termination and antitermination
HRL51_RS09250	COG0436	Aminotransferase
HRL51_RS09260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRL51_RS09265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRL51_RS09280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRL51_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
HRL51_RS09310	COG0395	ABC-type sugar transport system, permease component
HRL51_RS09315	COG4209	transmembrane transport
HRL51_RS09320	COG1653	transport
HRL51_RS09325	COG1609	Transcriptional regulator
HRL51_RS09340	COG0395	ABC-type sugar transport system, permease component
HRL51_RS09350	COG1609	Transcriptional regulator
HRL51_RS09365	COG4214	carbohydrate transport
HRL51_RS09375	COG4213	ABC transporter substrate-binding protein
HRL51_RS09385	COG2084	Dehydrogenase
HRL51_RS09390	COG2017	converts alpha-aldose to the beta-anomer
HRL51_RS09395	COG0395	ABC-type sugar transport system, permease component
HRL51_RS09400	COG1175	transmembrane transport
HRL51_RS09415	COG1609	Transcriptional regulator
HRL51_RS09420	COG1609	Transcriptional regulator
HRL51_RS09425	COG3250	beta-galactosidase activity
HRL51_RS09430	COG2160	L-arabinose isomerase activity
HRL51_RS09435	COG0395	ABC-type sugar transport system, permease component
HRL51_RS09440	COG1175	transmembrane transport
HRL51_RS09450	COG1609	Transcriptional regulator
HRL51_RS09455	COG3534	alpha-L-arabinofuranosidase
HRL51_RS09465	COG3458	cephalosporin-C deacetylase activity
HRL51_RS09480	COG1175	transmembrane transport
HRL51_RS09485	COG1653	transport
HRL51_RS09490	COG1609	Transcriptional regulator
HRL51_RS09495	COG1653	transport
HRL51_RS09500	COG1609	Transcriptional regulator
HRL51_RS09505	COG1063	alcohol dehydrogenase
HRL51_RS09510	COG1070	Carbohydrate kinase
HRL51_RS09515	COG2115	Belongs to the xylose isomerase family
HRL51_RS09520	COG1940	carbohydrate kinase activity
HRL51_RS09520	COG1846	Transcriptional regulator
HRL51_RS09550	COG0395	ABC-type sugar transport system, permease component
HRL51_RS09555	COG1175	transmembrane transport
HRL51_RS09560	COG1653	transport
HRL51_RS09565	COG1609	Transcriptional regulator
HRL51_RS09575	COG2376	Dihydroxyacetone kinase
HRL51_RS09585	COG2271	Major facilitator Superfamily
HRL51_RS09595	COG2271	Major facilitator Superfamily
HRL51_RS09600	COG3618	amidohydrolase
HRL51_RS09610	COG0149	triose-phosphate isomerase activity
HRL51_RS09615	COG2376	Dihydroxyacetone kinase
HRL51_RS09620	COG2610	gluconate transmembrane transporter activity
HRL51_RS09625	COG2084	Dehydrogenase
HRL51_RS09630	COG1082	Xylose isomerase domain protein TIM barrel
HRL51_RS09635	COG2186	Transcriptional regulator
HRL51_RS09640	COG0698	ribose 5-phosphate isomerase
HRL51_RS09680	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HRL51_RS09695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRL51_RS09705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRL51_RS09710	COG0247	lactate metabolic process
HRL51_RS09720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRL51_RS09725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRL51_RS09730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRL51_RS09735	COG1620	l-lactate permease
HRL51_RS09740	COG0247	lactate metabolic process
HRL51_RS09745	COG1139	Iron-sulfur cluster binding protein
HRL51_RS09750	COG1556	Lactate utilization protein
HRL51_RS09760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRL51_RS09780	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRL51_RS09785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRL51_RS09810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRL51_RS09825	COG0302	gtp cyclohydrolase
HRL51_RS09830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRL51_RS09835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HRL51_RS09845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRL51_RS09855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRL51_RS09870	COG0574	Belongs to the PEP-utilizing enzyme family
HRL51_RS09870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRL51_RS09875	COG0477	Major facilitator Superfamily
HRL51_RS09880	COG0477	Major facilitator Superfamily
HRL51_RS09885	COG0542	response to heat
HRL51_RS09890	COG1490	D-aminoacyl-tRNA deacylase activity
HRL51_RS09900	COG0354	folic acid binding
HRL51_RS09905	COG3485	protocatechuate 3,4-dioxygenase
HRL51_RS09910	COG0745	RESPONSE REGULATOR receiver
HRL51_RS09920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRL51_RS09940	COG0494	nUDIX hydrolase
HRL51_RS09940	COG0406	alpha-ribazole phosphatase activity
HRL51_RS09945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRL51_RS09965	COG3265	gluconokinase activity
HRL51_RS09975	COG2261	transglycosylase associated protein
HRL51_RS09980	COG0513	Belongs to the DEAD box helicase family
HRL51_RS10000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRL51_RS10020	COG0243	molybdopterin cofactor binding
HRL51_RS10025	COG0437	4 iron, 4 sulfur cluster binding
HRL51_RS10035	COG3381	protein complex oligomerization
HRL51_RS10065	COG2723	6-phospho-beta-galactosidase activity
HRL51_RS10110	COG1472	Belongs to the glycosyl hydrolase 3 family
HRL51_RS10120	COG1132	(ABC) transporter
HRL51_RS10125	COG1132	(ABC) transporter
HRL51_RS10160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRL51_RS10170	COG1105	Belongs to the carbohydrate kinase PfkB family
HRL51_RS10180	COG0737	Belongs to the 5'-nucleotidase family
HRL51_RS10185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRL51_RS10195	COG1316	TRANSCRIPTIONal
HRL51_RS10200	COG0489	protein tyrosine kinase activity
HRL51_RS10225	COG1215	transferase activity, transferring glycosyl groups
HRL51_RS10240	COG1132	(ABC) transporter
HRL51_RS10260	COG1083	cytidylyl-transferase
HRL51_RS10265	COG2089	acid synthase
HRL51_RS10285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRL51_RS10295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRL51_RS10300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRL51_RS10320	COG0047	phosphoribosylformylglycinamidine synthase activity
HRL51_RS10330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRL51_RS10335	COG0151	Belongs to the GarS family
HRL51_RS10340	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HRL51_RS10350	COG2837	iron assimilation
HRL51_RS10360	COG0672	)-iron permease
HRL51_RS10365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRL51_RS10370	COG0577	efflux transmembrane transporter activity
HRL51_RS10370	COG1136	(ABC) transporter
HRL51_RS10390	COG0191	fructose-bisphosphate aldolase activity
HRL51_RS10405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRL51_RS10420	COG0778	Nitroreductase
HRL51_RS10425	COG2176	DNA-directed DNA polymerase activity
HRL51_RS10435	COG0717	Belongs to the dCTP deaminase family
HRL51_RS10465	COG4221	oxidoreductase activity
HRL51_RS10495	COG5650	phosphatidylinositol metabolic process
HRL51_RS10515	COG2860	membrane
HRL51_RS10525	COG0842	Transport permease protein
HRL51_RS10525	COG1131	(ABC) transporter
HRL51_RS10525	COG1716	ATPase activity
HRL51_RS10535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRL51_RS10540	COG1132	(ABC) transporter
HRL51_RS10560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRL51_RS10590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRL51_RS10605	COG1940	carbohydrate kinase activity
HRL51_RS10610	COG1505	serine-type exopeptidase activity
HRL51_RS10615	COG0477	Major facilitator Superfamily
HRL51_RS10620	COG0110	maltose O-acetyltransferase activity
HRL51_RS10650	COG0673	inositol 2-dehydrogenase activity
HRL51_RS10660	COG3507	Belongs to the glycosyl hydrolase 43 family
HRL51_RS10670	COG1472	Belongs to the glycosyl hydrolase 3 family
HRL51_RS10675	COG2211	Major facilitator Superfamily
HRL51_RS10725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRL51_RS10730	COG1329	Transcriptional regulator
HRL51_RS10735	COG0745	RESPONSE REGULATOR receiver
HRL51_RS10740	COG5002	protein histidine kinase activity
HRL51_RS10750	COG0588	phosphoglycerate mutase activity
HRL51_RS10775	COG1113	amino acid transport
HRL51_RS10780	COG0252	asparaginase activity
HRL51_RS10790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRL51_RS10795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRL51_RS10800	COG1609	Transcriptional regulator
HRL51_RS10820	COG1175	transmembrane transport
HRL51_RS10825	COG0395	ABC-type sugar transport system, permease component
HRL51_RS10830	COG2235	arginine
HRL51_RS10835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRL51_RS10840	COG0549	Belongs to the carbamate kinase family
HRL51_RS10845	COG1834	amidinotransferase
HRL51_RS10855	COG0477	Major facilitator Superfamily
HRL51_RS10865	COG1754	DNA topoisomerase type I activity
HRL51_RS10865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRL51_RS10875	COG1472	Belongs to the glycosyl hydrolase 3 family
HRL51_RS10885	COG2890	protein-(glutamine-N5) methyltransferase activity
HRL51_RS10940	COG0596	Alpha beta hydrolase
HRL51_RS10965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRL51_RS10980	COG1597	lipid kinase activity
HRL51_RS10995	COG0494	nUDIX hydrolase
HRL51_RS11020	COG1136	(ABC) transporter
HRL51_RS11020	COG0577	efflux transmembrane transporter activity
HRL51_RS11040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRL51_RS11045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRL51_RS11055	COG0181	hydroxymethylbilane synthase activity
HRL51_RS11065	COG0113	porphobilinogen synthase activity
HRL51_RS11070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRL51_RS11085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRL51_RS11100	COG0488	(ABC) transporter
HRL51_RS11105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRL51_RS11160	COG2233	PERMEase
HRL51_RS11200	COG1643	Atp-dependent helicase
HRL51_RS11225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRL51_RS11230	COG2011	ABC-type metal ion transport system permease component
HRL51_RS11235	COG1464	Belongs to the NlpA lipoprotein family
HRL51_RS11240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRL51_RS11245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRL51_RS11250	COG0590	tRNA wobble adenosine to inosine editing
HRL51_RS11250	COG0037	tRNA processing
HRL51_RS11280	COG0747	negative chemotaxis
HRL51_RS11300	COG0601	transmembrane transport
HRL51_RS11320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRL51_RS11325	COG0572	uridine kinase
HRL51_RS11330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRL51_RS11335	COG1780	Probably involved in ribonucleotide reductase function
HRL51_RS11345	COG1827	regulation of RNA biosynthetic process
HRL51_RS11350	COG0366	Alpha amylase catalytic
HRL51_RS11355	COG1760	l-serine dehydratase
HRL51_RS11365	COG1733	regulation of RNA biosynthetic process
HRL51_RS11370	COG2910	NAD(P)H-binding
HRL51_RS11375	COG0351	phosphomethylpyrimidine kinase
HRL51_RS11380	COG0305	Participates in initiation and elongation during chromosome replication
HRL51_RS11385	COG0534	Mate efflux family protein
HRL51_RS11390	COG0359	binds to the 23S rRNA
HRL51_RS11395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRL51_RS11405	COG0360	Binds together with S18 to 16S ribosomal RNA
HRL51_RS11410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRL51_RS11435	COG2211	Major facilitator Superfamily
HRL51_RS11455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRL51_RS11460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRL51_RS11465	COG0617	tRNA 3'-terminal CCA addition
HRL51_RS11485	COG0492	ferredoxin-NADP+ reductase activity
HRL51_RS11490	COG3118	belongs to the thioredoxin family
HRL51_RS11495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRL51_RS11500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRL51_RS11505	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRL51_RS11520	COG0357	Ribosomal RNA small subunit methyltransferase G
HRL51_RS11530	COG0706	membrane insertase activity
HRL51_RS11535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRL51_RS11540	COG0594	ribonuclease P activity
HRL51_RS11545	COG0230	Belongs to the bacterial ribosomal protein bL34 family