locus-tag	class	description
E4J16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4J16_RS00010	COG0592	DNA-directed DNA polymerase activity
E4J16_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4J16_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E4J16_RS00025	COG0187	DNA topoisomerase II activity
E4J16_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4J16_RS00070	COG0656	L-ascorbic acid biosynthetic process
E4J16_RS00080	COG3764	Sortase (surface protein transpeptidase)
E4J16_RS00095	COG0768	penicillin binding
E4J16_RS00110	COG1716	ATPase activity
E4J16_RS00115	COG1716	ATPase activity
E4J16_RS00130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4J16_RS00135	COG1902	pentaerythritol trinitrate reductase activity
E4J16_RS00150	COG1966	Carbon starvation protein
E4J16_RS00155	COG2985	domain, Protein
E4J16_RS00155	COG0569	domain protein
E4J16_RS00165	COG1733	regulation of RNA biosynthetic process
E4J16_RS00170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4J16_RS00180	COG1854	S-ribosylhomocysteine lyase activity
E4J16_RS00190	COG0471	metal ion transport
E4J16_RS00195	COG3852	Histidine kinase
E4J16_RS00205	COG0628	permease
E4J16_RS00210	COG2226	methyltransferase
E4J16_RS00240	COG1120	ATPase activity
E4J16_RS00245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4J16_RS00250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4J16_RS00260	COG0110	maltose O-acetyltransferase activity
E4J16_RS00270	COG1940	carbohydrate kinase activity
E4J16_RS00295	COG2226	methyltransferase
E4J16_RS00345	COG1131	(ABC) transporter
E4J16_RS00385	COG1131	(ABC) transporter
E4J16_RS00430	COG1937	Protein conserved in bacteria
E4J16_RS00470	COG1950	PFAM Membrane protein of
E4J16_RS00475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4J16_RS00510	COG3833	ABC-type maltose transport systems, permease component
E4J16_RS00515	COG1175	transmembrane transport
E4J16_RS00540	COG1486	melibiose metabolic process
E4J16_RS00555	COG0656	L-ascorbic acid biosynthetic process
E4J16_RS00560	COG0667	Aldo Keto reductase
E4J16_RS00570	COG0531	amino acid
E4J16_RS00580	COG3250	beta-galactosidase activity
E4J16_RS00585	COG1609	Transcriptional regulator
E4J16_RS00610	COG3588	fructose-bisphosphate aldolase
E4J16_RS00625	COG2211	Major facilitator Superfamily
E4J16_RS00670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4J16_RS00675	COG2011	ABC-type metal ion transport system permease component
E4J16_RS00690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4J16_RS00695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4J16_RS00700	COG0037	tRNA processing
E4J16_RS00700	COG0590	tRNA wobble adenosine to inosine editing
E4J16_RS00710	COG1643	Atp-dependent helicase
E4J16_RS00715	COG1643	Atp-dependent helicase
E4J16_RS00740	COG0519	Catalyzes the synthesis of GMP from XMP
E4J16_RS00740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4J16_RS00865	COG1674	ftsk spoiiie
E4J16_RS00895	COG1827	regulation of RNA biosynthetic process
E4J16_RS00905	COG1780	Probably involved in ribonucleotide reductase function
E4J16_RS00910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4J16_RS00915	COG0385	Bile acid
E4J16_RS00925	COG1253	flavin adenine dinucleotide binding
E4J16_RS00965	COG1757	Na H antiporter
E4J16_RS00970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4J16_RS00985	COG3842	ATPase activity
E4J16_RS00990	COG1178	ABC-type Fe3 transport system permease component
E4J16_RS00995	COG1840	ABC-type Fe3 transport system, periplasmic component
E4J16_RS01000	COG0745	RESPONSE REGULATOR receiver
E4J16_RS01005	COG3852	Histidine kinase
E4J16_RS01040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4J16_RS01050	COG1653	transport
E4J16_RS01075	COG2963	transposase activity
E4J16_RS01110	COG0778	Nitroreductase
E4J16_RS01130	COG1404	Belongs to the peptidase S8 family
E4J16_RS01155	COG0626	cystathionine gamma-synthase activity
E4J16_RS01160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4J16_RS01200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4J16_RS01250	COG1201	RNA secondary structure unwinding
E4J16_RS01280	COG2181	nitrate reductase activity
E4J16_RS01280	COG0247	lactate metabolic process
E4J16_RS01285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4J16_RS01345	COG3842	ATPase activity
E4J16_RS01365	COG0151	Belongs to the GarS family
E4J16_RS01370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4J16_RS01390	COG0047	phosphoribosylformylglycinamidine synthase activity
E4J16_RS01395	COG0438	transferase activity, transferring glycosyl groups
E4J16_RS01410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4J16_RS01435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4J16_RS01440	COG4085	toxin activity
E4J16_RS01440	COG1525	nuclease
E4J16_RS01440	COG0737	Belongs to the 5'-nucleotidase family
E4J16_RS01450	COG1349	DNA-binding transcription factor activity
E4J16_RS01460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4J16_RS01460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4J16_RS01460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4J16_RS01465	COG0737	Belongs to the 5'-nucleotidase family
E4J16_RS01475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4J16_RS01500	COG1132	(ABC) transporter
E4J16_RS01505	COG1132	(ABC) transporter
E4J16_RS01510	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4J16_RS01520	COG1136	(ABC) transporter
E4J16_RS01550	COG2723	6-phospho-beta-galactosidase activity
E4J16_RS01585	COG2272	Belongs to the type-B carboxylesterase lipase family
E4J16_RS01590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4J16_RS01605	COG2261	transglycosylase associated protein
E4J16_RS01630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4J16_RS01635	COG0494	nUDIX hydrolase
E4J16_RS01635	COG0406	alpha-ribazole phosphatase activity
E4J16_RS01650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4J16_RS01675	COG0596	Alpha beta hydrolase
E4J16_RS01685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4J16_RS01740	COG2890	protein-(glutamine-N5) methyltransferase activity
E4J16_RS01800	COG2205	protein histidine kinase activity
E4J16_RS01805	COG0745	RESPONSE REGULATOR receiver
E4J16_RS01820	COG1754	DNA topoisomerase type I activity
E4J16_RS01820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4J16_RS01835	COG0477	Major facilitator Superfamily
E4J16_RS01845	COG1834	amidinotransferase
E4J16_RS01850	COG0549	Belongs to the carbamate kinase family
E4J16_RS01855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4J16_RS01870	COG0745	RESPONSE REGULATOR receiver
E4J16_RS01880	COG2885	chlorophyll binding
E4J16_RS01885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4J16_RS01890	COG0470	DNA polymerase III
E4J16_RS01905	COG0252	asparaginase activity
E4J16_RS01920	COG0588	phosphoglycerate mutase activity
E4J16_RS01925	COG0704	Plays a role in the regulation of phosphate uptake
E4J16_RS01930	COG5002	protein histidine kinase activity
E4J16_RS01940	COG1329	Transcriptional regulator
E4J16_RS01955	COG1764	response to oxidative stress
E4J16_RS02035	COG1940	carbohydrate kinase activity
E4J16_RS02040	COG2211	Major facilitator Superfamily
E4J16_RS02045	COG1472	Belongs to the glycosyl hydrolase 3 family
E4J16_RS02055	COG3507	Belongs to the glycosyl hydrolase 43 family
E4J16_RS02085	COG0673	inositol 2-dehydrogenase activity
E4J16_RS02110	COG1132	(ABC) transporter
E4J16_RS02115	COG1132	(ABC) transporter
E4J16_RS02150	COG2723	6-phospho-beta-galactosidase activity
E4J16_RS02155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4J16_RS02155	COG2190	(PTS) system
E4J16_RS02155	COG1263	PTS System
E4J16_RS02160	COG1737	Transcriptional regulator
E4J16_RS02170	COG0110	maltose O-acetyltransferase activity
E4J16_RS02175	COG0477	Major facilitator Superfamily
E4J16_RS02190	COG1505	serine-type exopeptidase activity
E4J16_RS02200	COG3250	beta-galactosidase activity
E4J16_RS02205	COG2723	6-phospho-beta-galactosidase activity
E4J16_RS02235	COG3250	beta-galactosidase activity
E4J16_RS02250	COG2272	Belongs to the type-B carboxylesterase lipase family
E4J16_RS02255	COG2211	Major facilitator Superfamily
E4J16_RS02260	COG3250	beta-galactosidase activity
E4J16_RS02280	COG0747	negative chemotaxis
E4J16_RS02295	COG4172	Belongs to the ABC transporter superfamily
E4J16_RS02300	COG3250	beta-galactosidase activity
E4J16_RS02325	COG3507	Belongs to the glycosyl hydrolase 43 family
E4J16_RS02330	COG3250	beta-galactosidase activity
E4J16_RS02355	COG3250	beta-galactosidase activity
E4J16_RS02375	COG1070	Carbohydrate kinase
E4J16_RS02385	COG2814	Major facilitator Superfamily
E4J16_RS02475	COG2814	Major facilitator Superfamily
E4J16_RS02480	COG1609	Transcriptional regulator
E4J16_RS02500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4J16_RS02510	COG2197	response regulator
E4J16_RS02520	COG1136	(ABC) transporter
E4J16_RS02520	COG0577	efflux transmembrane transporter activity
E4J16_RS02540	COG1643	Atp-dependent helicase
E4J16_RS02545	COG3711	transcriptional antiterminator
E4J16_RS02545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4J16_RS02575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4J16_RS02585	COG1842	Phage shock protein A
E4J16_RS02600	COG1061	Type III restriction enzyme res subunit
E4J16_RS02605	COG1940	carbohydrate kinase activity
E4J16_RS02610	COG1175	transmembrane transport
E4J16_RS02615	COG0395	ABC-type sugar transport system, permease component
E4J16_RS02625	COG3345	alpha-galactosidase
E4J16_RS02645	COG2252	PERMEase
E4J16_RS02695	COG1970	mechanosensitive ion channel activity
E4J16_RS02705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4J16_RS02755	COG3328	transposase activity
E4J16_RS02760	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
E4J16_RS02780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4J16_RS02800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4J16_RS02805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4J16_RS02810	COG0488	(ABC) transporter
E4J16_RS02850	COG0714	Associated with various cellular activities
E4J16_RS02860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4J16_RS02860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4J16_RS02870	COG1309	transcriptional regulator
E4J16_RS02920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4J16_RS02955	COG2244	polysaccharide biosynthetic process
E4J16_RS02975	COG0148	phosphopyruvate hydratase activity
E4J16_RS03005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4J16_RS03010	COG0193	aminoacyl-tRNA hydrolase activity
E4J16_RS03015	COG2197	response regulator
E4J16_RS03020	COG4585	Histidine kinase
E4J16_RS03030	COG1131	(ABC) transporter
E4J16_RS03050	COG0129	dihydroxy-acid dehydratase activity
E4J16_RS03065	COG1131	(ABC) transporter
E4J16_RS03070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4J16_RS03075	COG0431	NADPH-dependent FMN reductase
E4J16_RS03115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4J16_RS03120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4J16_RS03125	COG2326	polyphosphate kinase activity
E4J16_RS03135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4J16_RS03140	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4J16_RS03150	COG1722	exodeoxyribonuclease VII activity
E4J16_RS03155	COG4209	transmembrane transport
E4J16_RS03160	COG0395	ABC-type sugar transport system, permease component
E4J16_RS03180	COG1570	exodeoxyribonuclease VII activity
E4J16_RS03185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4J16_RS03195	COG1322	Protein conserved in bacteria
E4J16_RS03200	COG0012	GTP binding
E4J16_RS03230	COG2267	carboxylic ester hydrolase activity
E4J16_RS03300	COG2304	oxidoreductase activity
E4J16_RS03315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4J16_RS03330	COG0076	glutamate decarboxylase activity
E4J16_RS03335	COG0531	amino acid
E4J16_RS03365	COG0546	phosphoglycolate phosphatase activity
E4J16_RS03375	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4J16_RS03380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4J16_RS03385	COG1362	aminopeptidase activity
E4J16_RS03390	COG1902	pentaerythritol trinitrate reductase activity
E4J16_RS03395	COG4667	esterase of the alpha-beta hydrolase superfamily
E4J16_RS03415	COG1268	BioY protein
E4J16_RS03430	COG0601	transmembrane transport
E4J16_RS03435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4J16_RS03455	COG1217	gtp-binding protein TYPA
E4J16_RS03485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4J16_RS03485	COG3711	transcriptional antiterminator
E4J16_RS03490	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4J16_RS03495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4J16_RS03500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4J16_RS03505	COG2723	6-phospho-beta-galactosidase activity
E4J16_RS03520	COG1609	Transcriptional regulator
E4J16_RS03530	COG0601	transmembrane transport
E4J16_RS03535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4J16_RS03540	COG0444	Belongs to the ABC transporter superfamily
E4J16_RS03545	COG4608	Belongs to the ABC transporter superfamily
E4J16_RS03560	COG1053	succinate dehydrogenase
E4J16_RS03570	COG2171	N-acyltransferase activity
E4J16_RS03575	COG0406	alpha-ribazole phosphatase activity
E4J16_RS03590	COG1131	(ABC) transporter
E4J16_RS03595	COG2197	response regulator
E4J16_RS03635	COG3477	response to acidic pH
E4J16_RS03645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4J16_RS03650	COG2197	response regulator
E4J16_RS03675	COG2235	arginine
E4J16_RS03680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4J16_RS03700	COG0577	efflux transmembrane transporter activity
E4J16_RS03700	COG1136	(ABC) transporter
E4J16_RS03705	COG3409	Peptidoglycan-binding domain 1 protein
E4J16_RS03720	COG4948	Mandelate Racemase Muconate Lactonizing
E4J16_RS03725	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4J16_RS03740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4J16_RS03745	COG0254	rRNA binding
E4J16_RS03750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4J16_RS03755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4J16_RS03770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4J16_RS03775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4J16_RS03795	COG0577	efflux transmembrane transporter activity
E4J16_RS03800	COG0577	efflux transmembrane transporter activity
E4J16_RS03800	COG1136	(ABC) transporter
E4J16_RS03810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4J16_RS03825	COG1744	ABC transporter substrate-binding protein PnrA-like
E4J16_RS03830	COG3845	ABC transporter
E4J16_RS03835	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4J16_RS03840	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4J16_RS03860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4J16_RS03865	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4J16_RS03870	COG1121	(ABC) transporter
E4J16_RS03885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4J16_RS03890	COG1611	Belongs to the LOG family
E4J16_RS03920	COG2239	Acts as a magnesium transporter
E4J16_RS03930	COG1082	Xylose isomerase domain protein TIM barrel
E4J16_RS03940	COG0006	proline dipeptidase activity
E4J16_RS03945	COG0673	inositol 2-dehydrogenase activity
E4J16_RS03955	COG2095	MarC family integral membrane protein
E4J16_RS03960	COG0513	Belongs to the DEAD box helicase family
E4J16_RS04045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4J16_RS04090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4J16_RS04095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4J16_RS04105	COG2190	(PTS) system
E4J16_RS04105	COG1263	PTS System
E4J16_RS04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4J16_RS04115	COG2271	Major facilitator Superfamily
E4J16_RS04120	COG1349	DNA-binding transcription factor activity
E4J16_RS04125	COG1063	alcohol dehydrogenase
E4J16_RS04130	COG1830	Aldolase
E4J16_RS04135	COG1070	Carbohydrate kinase
E4J16_RS04140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4J16_RS04145	COG1929	Belongs to the glycerate kinase type-1 family
E4J16_RS04150	COG1316	TRANSCRIPTIONal
E4J16_RS04160	COG3590	peptidase
E4J16_RS04175	COG1045	serine acetyltransferase
E4J16_RS04185	COG1739	Uncharacterized protein family UPF0029
E4J16_RS04210	COG2040	homocysteine
E4J16_RS04215	COG0833	amino acid
E4J16_RS04225	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4J16_RS04240	COG0740	serine-type endopeptidase activity
E4J16_RS04250	COG1683	Conserved Protein
E4J16_RS04270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4J16_RS04285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4J16_RS04295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4J16_RS04320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4J16_RS04330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4J16_RS04340	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4J16_RS04350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4J16_RS04355	COG1461	Dihydroxyacetone kinase
E4J16_RS04385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4J16_RS04400	COG0571	ribonuclease III activity
E4J16_RS04405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4J16_RS04420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4J16_RS04425	COG4988	ABC transporter
E4J16_RS04430	COG1294	oxidase, subunit
E4J16_RS04435	COG1271	oxidase subunit
E4J16_RS04440	COG1530	ribonuclease E activity
E4J16_RS04445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4J16_RS04450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4J16_RS04455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4J16_RS04460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E4J16_RS04465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4J16_RS04475	COG0745	RESPONSE REGULATOR receiver
E4J16_RS04480	COG5002	protein histidine kinase activity
E4J16_RS04495	COG1132	(ABC) transporter
E4J16_RS04505	COG0438	transferase activity, transferring glycosyl groups
E4J16_RS04515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4J16_RS04520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4J16_RS04530	COG0799	negative regulation of ribosome biogenesis
E4J16_RS04550	COG1968	undecaprenyl-diphosphatase activity
E4J16_RS04555	COG0483	inositol monophosphate 1-phosphatase activity
E4J16_RS04565	COG0577	efflux transmembrane transporter activity
E4J16_RS04565	COG1136	(ABC) transporter
E4J16_RS04575	COG2197	response regulator
E4J16_RS04595	COG0110	maltose O-acetyltransferase activity
E4J16_RS04600	COG1063	alcohol dehydrogenase
E4J16_RS04605	COG1120	ATPase activity
E4J16_RS04610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4J16_RS04615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4J16_RS04620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4J16_RS04645	COG1140	nitrate reductase beta subunit
E4J16_RS04660	COG0315	cyclic pyranopterin monophosphate synthase activity
E4J16_RS04660	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4J16_RS04670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4J16_RS04670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4J16_RS04675	COG0315	cyclic pyranopterin monophosphate synthase activity
E4J16_RS04695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4J16_RS04715	COG1162	GTPase activity
E4J16_RS04720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4J16_RS04725	COG2838	Isocitrate dehydrogenase
E4J16_RS04735	COG1595	DNA-templated transcription, initiation
E4J16_RS04760	COG0741	lytic transglycosylase activity
E4J16_RS04760	COG1196	nuclear chromosome segregation
E4J16_RS04760	COG0739	heme binding
E4J16_RS04765	COG0584	glycerophosphoryl diester phosphodiesterase
E4J16_RS04800	COG0018	arginyl-trna synthetase
E4J16_RS04805	COG0019	diaminopimelate decarboxylase activity
E4J16_RS04810	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
E4J16_RS04825	COG0460	homoserine dehydrogenase
E4J16_RS04830	COG0083	homoserine kinase activity
E4J16_RS04840	COG0254	rRNA binding
E4J16_RS04845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4J16_RS04880	COG0110	maltose O-acetyltransferase activity
E4J16_RS04890	COG1472	Belongs to the glycosyl hydrolase 3 family
E4J16_RS04900	COG1653	transport
E4J16_RS04915	COG0366	Alpha amylase catalytic
E4J16_RS04920	COG1609	Transcriptional regulator
E4J16_RS04925	COG1501	Belongs to the glycosyl hydrolase 31 family
E4J16_RS04930	COG1609	Transcriptional regulator
E4J16_RS04935	COG1846	Transcriptional regulator
E4J16_RS04935	COG1940	carbohydrate kinase activity
E4J16_RS04945	COG1175	transmembrane transport
E4J16_RS04955	COG0366	Alpha amylase catalytic
E4J16_RS04960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4J16_RS04980	COG0205	6-phosphofructokinase activity
E4J16_RS05000	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4J16_RS05005	COG0039	L-malate dehydrogenase activity
E4J16_RS05020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4J16_RS05045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4J16_RS05065	COG0058	SHG alpha-glucan phosphorylase activity
E4J16_RS05070	COG2226	methyltransferase
E4J16_RS05075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4J16_RS05080	COG3281	Trehalose synthase
E4J16_RS05090	COG0366	Alpha amylase catalytic
E4J16_RS05105	COG2086	electron transfer activity
E4J16_RS05110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4J16_RS05115	COG1725	Transcriptional regulator
E4J16_RS05120	COG1131	(ABC) transporter
E4J16_RS05130	COG0482	sulfurtransferase activity
E4J16_RS05165	COG3480	Lon protease (S16) C-terminal proteolytic domain
E4J16_RS05180	COG1615	UPF0182 protein
E4J16_RS05200	COG0114	fumarate hydratase activity
E4J16_RS05230	COG1174	glycine betaine transport
E4J16_RS05235	COG1174	glycine betaine transport
E4J16_RS05250	COG0673	inositol 2-dehydrogenase activity
E4J16_RS05260	COG2814	Major facilitator Superfamily
E4J16_RS05270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4J16_RS05300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4J16_RS05310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4J16_RS05315	COG0154	amidase activity
E4J16_RS05320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4J16_RS05350	COG0647	UMP catabolic process
E4J16_RS05365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4J16_RS05370	COG0497	DNA recombination
E4J16_RS05510	COG1674	ftsk spoiiie
E4J16_RS05540	COG2610	gluconate transmembrane transporter activity
E4J16_RS05545	COG2084	Dehydrogenase
E4J16_RS05555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4J16_RS05600	COG0569	domain protein
E4J16_RS05605	COG0531	amino acid
E4J16_RS05610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4J16_RS05615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4J16_RS05630	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4J16_RS05635	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4J16_RS05650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4J16_RS05655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4J16_RS05660	COG4221	oxidoreductase activity
E4J16_RS05665	COG1881	PFAM PEBP family protein
E4J16_RS05680	COG0671	phosphoesterase, PA-phosphatase related
E4J16_RS05685	COG1435	thymidine kinase activity
E4J16_RS05700	COG0587	DNA-directed DNA polymerase activity
E4J16_RS05710	COG0546	phosphoglycolate phosphatase activity
E4J16_RS05715	COG0676	glucose-6-phosphate 1-epimerase activity
E4J16_RS05730	COG0339	signal peptide processing
E4J16_RS05740	COG0667	Aldo Keto reductase
E4J16_RS05745	COG0425	Belongs to the sulfur carrier protein TusA family
E4J16_RS05750	COG2391	methyltransferase activity
E4J16_RS05760	COG1129	ABC transporter
E4J16_RS05765	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4J16_RS05770	COG1879	ABC-type sugar transport system periplasmic component
E4J16_RS05775	COG0517	IMP dehydrogenase activity
E4J16_RS05775	COG1994	Peptidase M50
E4J16_RS05780	COG2264	protein methyltransferase activity
E4J16_RS05795	COG1222	aaa ATPase
E4J16_RS05800	COG4122	O-methyltransferase activity
E4J16_RS05810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E4J16_RS05820	COG0107	imidazoleglycerol-phosphate synthase activity
E4J16_RS05840	COG0134	indole-3-glycerol-phosphate synthase activity
E4J16_RS05845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4J16_RS05865	COG1120	ATPase activity
E4J16_RS05870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4J16_RS05880	COG1834	amidinotransferase
E4J16_RS05900	COG2050	protein possibly involved in aromatic compounds catabolism
E4J16_RS05910	COG0539	negative regulation of cytoplasmic translation
E4J16_RS05920	COG2076	Multidrug Resistance protein
E4J16_RS05930	COG0237	dephospho-CoA kinase activity
E4J16_RS05935	COG0556	nucleotide-excision repair
E4J16_RS06005	COG0561	phosphatase activity
E4J16_RS06020	COG3711	transcriptional antiterminator
E4J16_RS06025	COG1263	PTS System
E4J16_RS06025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4J16_RS06025	COG2190	(PTS) system
E4J16_RS06035	COG3739	integral membrane protein
E4J16_RS06045	COG1660	Displays ATPase and GTPase activities
E4J16_RS06055	COG1481	regulation of sporulation
E4J16_RS06060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4J16_RS06070	COG0149	triose-phosphate isomerase activity
E4J16_RS06075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4J16_RS06110	COG1160	GTP binding
E4J16_RS06125	COG0519	Catalyzes the synthesis of GMP from XMP
E4J16_RS06130	COG0166	Belongs to the GPI family
E4J16_RS06215	COG4989	oxidoreductase activity
E4J16_RS06260	COG0667	Aldo Keto reductase
E4J16_RS06265	COG0443	Heat shock 70 kDa protein
E4J16_RS06280	COG1621	beta-fructofuranosidase activity
E4J16_RS06285	COG2190	(PTS) system
E4J16_RS06285	COG1263	PTS System
E4J16_RS06285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4J16_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
E4J16_RS06335	COG0205	6-phosphofructokinase activity
E4J16_RS06345	COG1216	Glycosyl transferase, family 2
E4J16_RS06360	COG0805	protein transport
E4J16_RS06365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4J16_RS06370	COG2378	regulation of single-species biofilm formation
E4J16_RS06385	COG0140	phosphoribosyl-ATP diphosphatase activity
E4J16_RS06390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4J16_RS06395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4J16_RS06400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4J16_RS06410	COG1355	regulation of microtubule-based process
E4J16_RS06415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4J16_RS06420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4J16_RS06420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4J16_RS06420	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4J16_RS06425	COG1461	Dihydroxyacetone kinase
E4J16_RS06430	COG2376	Dihydroxyacetone kinase
E4J16_RS06435	COG0736	holo-[acyl-carrier-protein] synthase activity
E4J16_RS06440	COG4115	mRNA cleavage
E4J16_RS06445	COG2161	toxin-antitoxin pair type II binding
E4J16_RS06455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4J16_RS06460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4J16_RS06465	COG4770	biotin carboxylase activity
E4J16_RS06470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4J16_RS06480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4J16_RS06495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4J16_RS06505	COG1758	RNA polymerase activity
E4J16_RS06510	COG0194	GDP metabolic process
E4J16_RS06520	COG0284	orotidine-5'-phosphate decarboxylase activity
E4J16_RS06525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4J16_RS06530	COG0505	Belongs to the CarA family
E4J16_RS06535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4J16_RS06545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E4J16_RS06550	COG0702	epimerase
E4J16_RS06585	COG2814	Major facilitator Superfamily
E4J16_RS06595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4J16_RS06600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4J16_RS06610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4J16_RS06620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4J16_RS06625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4J16_RS06635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4J16_RS06640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4J16_RS06645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4J16_RS06655	COG0730	response to heat
E4J16_RS06665	COG2409	Drug exporters of the RND superfamily
E4J16_RS06670	COG0009	L-threonylcarbamoyladenylate synthase
E4J16_RS06675	COG2207	Transcriptional regulator
E4J16_RS06680	COG1063	alcohol dehydrogenase
E4J16_RS06695	COG1131	(ABC) transporter
E4J16_RS06705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4J16_RS06735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4J16_RS06755	COG1196	nuclear chromosome segregation
E4J16_RS06800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4J16_RS06805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4J16_RS06810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4J16_RS06815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4J16_RS06825	COG2255	four-way junction helicase activity
E4J16_RS06830	COG0632	four-way junction helicase activity
E4J16_RS06835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4J16_RS06840	COG0217	transcriptional regulatory protein
E4J16_RS06860	COG0438	transferase activity, transferring glycosyl groups
E4J16_RS06865	COG1560	Kdo2-lipid A biosynthetic process
E4J16_RS06870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4J16_RS06880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4J16_RS06945	COG1882	Formate acetyltransferase
E4J16_RS06970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4J16_RS06975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4J16_RS06995	COG0515	serine threonine protein kinase
E4J16_RS06995	COG2815	serine threonine protein kinase
E4J16_RS07000	COG0321	lipoyl(octanoyl) transferase activity
E4J16_RS07005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4J16_RS07025	COG0765	amino acid transport
E4J16_RS07045	COG0406	alpha-ribazole phosphatase activity
E4J16_RS07060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4J16_RS07075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4J16_RS07075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4J16_RS07100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4J16_RS07115	COG0436	Aminotransferase
E4J16_RS07135	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4J16_RS07140	COG1027	Aspartate ammonia-lyase
E4J16_RS07150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4J16_RS07205	COG0358	DNA primase activity
E4J16_RS07220	COG2182	Extracellular solute-binding protein
E4J16_RS07230	COG3833	ABC-type maltose transport systems, permease component
E4J16_RS07240	COG1609	Transcriptional regulator
E4J16_RS07260	COG0667	Aldo Keto reductase
E4J16_RS07265	COG0167	dihydroorotate dehydrogenase activity
E4J16_RS07290	COG3189	MarR family transcriptional regulator
E4J16_RS07295	COG0789	Transcriptional regulator
E4J16_RS07300	COG1131	(ABC) transporter
E4J16_RS07310	COG2151	metal-sulfur cluster biosynthetic enzyme
E4J16_RS07315	COG0822	iron-sulfur transferase activity
E4J16_RS07325	COG0396	ATPase activity
E4J16_RS07330	COG0719	Fe-S assembly protein
E4J16_RS07340	COG1349	DNA-binding transcription factor activity
E4J16_RS07345	COG0477	Major facilitator Superfamily
E4J16_RS07355	COG0395	ABC-type sugar transport system, permease component
E4J16_RS07370	COG1609	Transcriptional regulator
E4J16_RS07400	COG0351	phosphomethylpyrimidine kinase
E4J16_RS07405	COG0352	thiamine-phosphate diphosphorylase activity
E4J16_RS07410	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E4J16_RS07415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4J16_RS07420	COG0142	geranyltranstransferase activity
E4J16_RS07425	COG0515	serine threonine protein kinase
E4J16_RS07425	COG2815	serine threonine protein kinase
E4J16_RS07430	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E4J16_RS07435	COG0205	6-phosphofructokinase activity
E4J16_RS07475	COG0488	(ABC) transporter
E4J16_RS07485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4J16_RS07485	COG2190	(PTS) system
E4J16_RS07485	COG1263	PTS System
E4J16_RS07515	COG1119	ATPase activity
E4J16_RS07525	COG0297	glycogen (starch) synthase activity
E4J16_RS07535	COG0560	Phosphoserine phosphatase
E4J16_RS07565	COG0423	glycine-tRNA ligase activity
E4J16_RS07575	COG1116	anion transmembrane transporter activity
E4J16_RS07580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4J16_RS07590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4J16_RS07595	COG1381	Involved in DNA repair and RecF pathway recombination
E4J16_RS07600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4J16_RS07615	COG1476	TRANSCRIPTIONal
E4J16_RS07620	COG1132	(ABC) transporter
E4J16_RS07625	COG1131	(ABC) transporter
E4J16_RS07640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4J16_RS07650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4J16_RS07700	COG1063	alcohol dehydrogenase
E4J16_RS07730	COG0484	heat shock protein binding
E4J16_RS07735	COG1420	regulation of RNA biosynthetic process
E4J16_RS07775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4J16_RS07785	COG0481	GTPase activity
E4J16_RS07805	COG1216	Glycosyl transferase, family 2
E4J16_RS07815	COG1472	Belongs to the glycosyl hydrolase 3 family
E4J16_RS07835	COG0133	tryptophan synthase activity
E4J16_RS07845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4J16_RS07850	COG0512	Glutamine amidotransferase of anthranilate synthase
E4J16_RS07855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4J16_RS07865	COG0159	tryptophan synthase activity
E4J16_RS07875	COG2855	membrane
E4J16_RS07880	COG2197	response regulator
E4J16_RS07885	COG4585	Histidine kinase
E4J16_RS07890	COG1131	(ABC) transporter
E4J16_RS07910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4J16_RS07930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4J16_RS07965	COG0268	Binds directly to 16S ribosomal RNA
E4J16_RS07970	COG4868	Belongs to the UPF0371 family
E4J16_RS07985	COG1555	photosystem II stabilization
E4J16_RS07995	COG0433	COG0433 Predicted ATPase
E4J16_RS08010	COG1965	Belongs to the frataxin family
E4J16_RS08015	COG0495	leucyl-tRNA aminoacylation
E4J16_RS08020	COG0537	adenosine 5'-monophosphoramidase activity
E4J16_RS08025	COG1321	iron dependent repressor
E4J16_RS08050	COG0733	neurotransmitter:sodium symporter activity
E4J16_RS08055	COG0813	purine-nucleoside phosphorylase activity
E4J16_RS08085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4J16_RS08100	COG2094	Belongs to the DNA glycosylase MPG family
E4J16_RS08105	COG0165	Argininosuccinate lyase
E4J16_RS08115	COG0137	argininosuccinate synthase activity
E4J16_RS08120	COG1438	arginine binding
E4J16_RS08125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4J16_RS08130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4J16_RS08140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4J16_RS08155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4J16_RS08165	COG1131	(ABC) transporter
E4J16_RS08215	COG0765	amino acid transport
E4J16_RS08220	COG0765	amino acid transport
E4J16_RS08230	COG1126	abc transporter atp-binding protein
E4J16_RS08235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4J16_RS08240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4J16_RS08245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4J16_RS08250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4J16_RS08260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4J16_RS08265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4J16_RS08275	COG0131	Imidazoleglycerol-phosphate dehydratase
E4J16_RS08315	COG5298	Protein conserved in bacteria
E4J16_RS08320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4J16_RS08355	COG3654	unkown
E4J16_RS08380	COG2501	S4 domain
E4J16_RS08395	COG0587	DNA-directed DNA polymerase activity
E4J16_RS08400	COG2153	protein acetylation
E4J16_RS08410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4J16_RS08415	COG3599	regulation of cell shape
E4J16_RS08430	COG1799	cell septum assembly
E4J16_RS08435	COG1496	oxidoreductase activity
E4J16_RS08450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4J16_RS08455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4J16_RS08465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4J16_RS08470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4J16_RS08480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4J16_RS08485	COG0768	penicillin binding
E4J16_RS08495	COG0275	rRNA processing
E4J16_RS08500	COG2001	Belongs to the MraZ family
E4J16_RS08510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4J16_RS08530	COG0318	PFAM AMP-dependent synthetase and ligase
E4J16_RS08535	COG0318	PFAM AMP-dependent synthetase and ligase
E4J16_RS08560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4J16_RS08575	COG0612	Peptidase, M16
E4J16_RS08580	COG1185	polyribonucleotide nucleotidyltransferase activity
E4J16_RS08585	COG1454	alcohol dehydrogenase
E4J16_RS08605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4J16_RS08610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4J16_RS08620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4J16_RS08630	COG0195	Participates in both transcription termination and antitermination
E4J16_RS08635	COG0779	Required for maturation of 30S ribosomal subunits
E4J16_RS08660	COG0442	prolyl-tRNA aminoacylation
E4J16_RS08675	COG0456	acetyltransferase
E4J16_RS08680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4J16_RS08685	COG0750	zinc metalloprotease
E4J16_RS08690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4J16_RS08700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4J16_RS08705	COG0575	Belongs to the CDS family
E4J16_RS08710	COG0233	cytoplasmic translational termination
E4J16_RS08720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4J16_RS08725	COG0052	Belongs to the universal ribosomal protein uS2 family
E4J16_RS08735	COG4974	Belongs to the 'phage' integrase family
E4J16_RS08740	COG1131	(ABC) transporter
E4J16_RS08760	COG0792	nuclease activity
E4J16_RS08770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4J16_RS08775	COG0681	Belongs to the peptidase S26 family
E4J16_RS08790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4J16_RS08795	COG1837	Belongs to the UPF0109 family
E4J16_RS08805	COG1115	amino acid carrier protein
E4J16_RS08835	COG4152	abc transporter atp-binding protein
E4J16_RS08845	COG0105	UTP biosynthetic process
E4J16_RS08850	COG0285	dihydrofolate synthase activity
E4J16_RS08860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4J16_RS08880	COG0438	transferase activity, transferring glycosyl groups
E4J16_RS08895	COG1215	transferase activity, transferring glycosyl groups
E4J16_RS08905	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4J16_RS08910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4J16_RS08910	COG1648	precorrin-2 dehydrogenase activity
E4J16_RS08920	COG2188	Transcriptional regulator
E4J16_RS08925	COG1263	PTS System
E4J16_RS08925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4J16_RS08925	COG2190	(PTS) system
E4J16_RS08930	COG0366	Alpha amylase catalytic
E4J16_RS08945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4J16_RS08950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4J16_RS08960	COG0438	transferase activity, transferring glycosyl groups
E4J16_RS08975	COG1086	Polysaccharide biosynthesis protein
E4J16_RS08980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4J16_RS09015	COG0287	Prephenate dehydrogenase
E4J16_RS09015	COG1605	Chorismate mutase
E4J16_RS09020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4J16_RS09025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4J16_RS09030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4J16_RS09050	COG1136	(ABC) transporter
E4J16_RS09050	COG0577	efflux transmembrane transporter activity
E4J16_RS09070	COG3470	protein probably involved in high-affinity Fe2 transport
E4J16_RS09075	COG0672	)-iron permease
E4J16_RS09095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4J16_RS09100	COG1252	NADH dehydrogenase
E4J16_RS09115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4J16_RS09125	COG1396	sequence-specific DNA binding
E4J16_RS09130	COG1546	Belongs to the CinA family
E4J16_RS09130	COG1058	Belongs to the CinA family
E4J16_RS09145	COG1674	ftsk spoiiie
E4J16_RS09155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4J16_RS09180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4J16_RS09195	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4J16_RS09200	COG1115	amino acid carrier protein
E4J16_RS09205	COG1115	amino acid carrier protein
E4J16_RS09210	COG1115	amino acid carrier protein
E4J16_RS09215	COG1115	amino acid carrier protein
E4J16_RS09235	COG3304	Inner membrane component domain
E4J16_RS09285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4J16_RS09290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4J16_RS09315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4J16_RS09325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4J16_RS09345	COG0363	glucosamine-6-phosphate deaminase activity
E4J16_RS09365	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E4J16_RS09370	COG1940	carbohydrate kinase activity
E4J16_RS09375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4J16_RS09380	COG4608	Belongs to the ABC transporter superfamily
E4J16_RS09385	COG0444	Belongs to the ABC transporter superfamily
E4J16_RS09395	COG0747	negative chemotaxis
E4J16_RS09425	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4J16_RS09465	COG0667	Aldo Keto reductase
E4J16_RS09480	COG2177	Part of the ABC transporter FtsEX involved in
E4J16_RS09485	COG2884	Cell division ATP-binding protein ftsE
E4J16_RS09515	COG0842	Transport permease protein
E4J16_RS09515	COG1131	(ABC) transporter
E4J16_RS09515	COG1716	ATPase activity
E4J16_RS09650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4J16_RS09790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4J16_RS09810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4J16_RS09820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4J16_RS09830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4J16_RS09850	COG1134	teichoic acid transport
E4J16_RS09860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4J16_RS09865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4J16_RS09880	COG0438	transferase activity, transferring glycosyl groups
E4J16_RS09885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4J16_RS09885	COG0463	Glycosyl transferase, family 2
E4J16_RS09890	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4J16_RS09910	COG1396	sequence-specific DNA binding
E4J16_RS09920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4J16_RS09925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4J16_RS09930	COG1316	TRANSCRIPTIONal
E4J16_RS09935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4J16_RS09940	COG0473	3-isopropylmalate dehydrogenase activity
E4J16_RS09945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4J16_RS09955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4J16_RS09960	COG0440	acetolactate synthase activity
E4J16_RS09970	COG0569	domain protein
E4J16_RS09970	COG2985	domain, Protein
E4J16_RS09975	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4J16_RS10005	COG0420	3'-5' exonuclease activity
E4J16_RS10010	COG0419	ATPase involved in DNA repair
E4J16_RS10050	COG0653	protein targeting
E4J16_RS10060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4J16_RS10065	COG5401	PFAM Sporulation and spore germination
E4J16_RS10070	COG5002	protein histidine kinase activity
E4J16_RS10070	COG5000	phosphorelay sensor kinase activity
E4J16_RS10075	COG0745	RESPONSE REGULATOR receiver
E4J16_RS10095	COG0714	Associated with various cellular activities
E4J16_RS10145	COG1482	cell wall glycoprotein biosynthetic process
E4J16_RS10165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4J16_RS10180	COG3754	Rhamnan synthesis protein F
E4J16_RS10345	COG1316	TRANSCRIPTIONal
E4J16_RS10350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4J16_RS10360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4J16_RS10385	COG0745	RESPONSE REGULATOR receiver
E4J16_RS10400	COG0424	maF-like protein
E4J16_RS10410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4J16_RS10430	COG0501	Belongs to the peptidase M48B family
E4J16_RS10435	COG0686	Belongs to the AlaDH PNT family
E4J16_RS10450	COG0142	geranyltranstransferase activity
E4J16_RS10455	COG1007	ATP synthesis coupled electron transport
E4J16_RS10465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4J16_RS10470	COG0713	ATP synthesis coupled electron transport
E4J16_RS10475	COG0839	Belongs to the complex I subunit 6 family
E4J16_RS10485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4J16_RS10490	COG1034	ATP synthesis coupled electron transport
E4J16_RS10495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4J16_RS10505	COG0649	NAD binding
E4J16_RS10510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4J16_RS10515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4J16_RS10530	COG2226	methyltransferase
E4J16_RS10535	COG1169	isochorismate synthase
E4J16_RS10560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4J16_RS10575	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E4J16_RS10580	COG1028	Short-chain dehydrogenase reductase Sdr
E4J16_RS10585	COG1309	transcriptional regulator
E4J16_RS10595	COG3848	Pyruvate phosphate dikinase
E4J16_RS10595	COG0574	Belongs to the PEP-utilizing enzyme family
E4J16_RS10605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4J16_RS10610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4J16_RS10615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4J16_RS10620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4J16_RS10625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4J16_RS10635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4J16_RS10640	COG0356	it plays a direct role in the translocation of protons across the membrane
E4J16_RS10650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4J16_RS10655	COG0009	L-threonylcarbamoyladenylate synthase
E4J16_RS10660	COG2197	response regulator
E4J16_RS10740	COG0583	DNA-binding transcription factor activity
E4J16_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
E4J16_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
E4J16_RS10785	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4J16_RS10800	COG4585	Histidine kinase
E4J16_RS10805	COG1131	(ABC) transporter
E4J16_RS10830	COG1609	Transcriptional regulator
E4J16_RS10840	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4J16_RS10850	COG0488	(ABC) transporter
E4J16_RS10855	COG0667	Aldo Keto reductase
E4J16_RS10875	COG1247	-acetyltransferase
E4J16_RS10880	COG3177	Filamentation induced by cAMP protein fic
E4J16_RS10890	COG0519	Catalyzes the synthesis of GMP from XMP
E4J16_RS10895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4J16_RS10895	COG0519	Catalyzes the synthesis of GMP from XMP
E4J16_RS10925	COG0673	inositol 2-dehydrogenase activity
E4J16_RS10930	COG1082	Xylose isomerase domain protein TIM barrel
E4J16_RS10935	COG1063	alcohol dehydrogenase
E4J16_RS10945	COG0673	inositol 2-dehydrogenase activity
E4J16_RS10955	COG2814	Major facilitator Superfamily
E4J16_RS10960	COG1082	Xylose isomerase domain protein TIM barrel
E4J16_RS10965	COG0673	inositol 2-dehydrogenase activity
E4J16_RS10980	COG3962	Belongs to the TPP enzyme family
E4J16_RS10985	COG3718	enzyme involved in inositol metabolism
E4J16_RS11005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4J16_RS11010	COG0673	inositol 2-dehydrogenase activity
E4J16_RS11015	COG1609	Transcriptional regulator
E4J16_RS11035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4J16_RS11040	COG0328	RNA-DNA hybrid ribonuclease activity
E4J16_RS11045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4J16_RS11055	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11070	COG0516	GMP reductase activity
E4J16_RS11085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4J16_RS11090	COG2949	membrane
E4J16_RS11100	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E4J16_RS11105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4J16_RS11125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4J16_RS11130	COG1053	succinate dehydrogenase
E4J16_RS11150	COG0802	atpase or kinase
E4J16_RS11155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4J16_RS11160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4J16_RS11160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4J16_RS11165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4J16_RS11170	COG1072	(Pantothenic acid kinase))
E4J16_RS11190	COG1733	regulation of RNA biosynthetic process
E4J16_RS11200	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4J16_RS11205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4J16_RS11235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4J16_RS11240	COG0101	tRNA pseudouridine synthase activity
E4J16_RS11245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4J16_RS11250	COG1940	carbohydrate kinase activity
E4J16_RS11255	COG0203	ribosomal protein L17
E4J16_RS11260	COG0202	RNA polymerase activity
E4J16_RS11265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4J16_RS11270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4J16_RS11275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4J16_RS11280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4J16_RS11290	COG0563	adenylate kinase activity
E4J16_RS11300	COG0200	Binds to the 23S rRNA
E4J16_RS11305	COG1841	ribosomal large subunit assembly
E4J16_RS11310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4J16_RS11320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4J16_RS11325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4J16_RS11330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4J16_RS11335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4J16_RS11340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4J16_RS11345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4J16_RS11355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4J16_RS11360	COG0255	Belongs to the universal ribosomal protein uL29 family
E4J16_RS11365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4J16_RS11370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4J16_RS11375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4J16_RS11385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4J16_RS11390	COG0089	rRNA binding
E4J16_RS11395	COG0088	Forms part of the polypeptide exit tunnel
E4J16_RS11400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4J16_RS11405	COG0051	transcription antitermination factor activity, RNA binding
E4J16_RS11410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4J16_RS11415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4J16_RS11420	COG0049	tRNA binding
E4J16_RS11425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4J16_RS11435	COG1100	Small GTP-binding protein
E4J16_RS11490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4J16_RS11495	COG0085	RNA polymerase activity
E4J16_RS11500	COG0222	ribosome binding
E4J16_RS11505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4J16_RS11510	COG2885	chlorophyll binding
E4J16_RS11515	COG0515	serine threonine protein kinase
E4J16_RS11520	COG0081	regulation of translation
E4J16_RS11525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4J16_RS11545	COG0436	Aminotransferase
E4J16_RS11550	COG4948	Mandelate Racemase Muconate Lactonizing
E4J16_RS11555	COG1115	amino acid carrier protein
E4J16_RS11565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4J16_RS11570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4J16_RS11585	COG1175	transmembrane transport
E4J16_RS11590	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11595	COG3507	Belongs to the glycosyl hydrolase 43 family
E4J16_RS11620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4J16_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
E4J16_RS11660	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11665	COG4209	transmembrane transport
E4J16_RS11675	COG1609	Transcriptional regulator
E4J16_RS11685	COG1472	Belongs to the glycosyl hydrolase 3 family
E4J16_RS11690	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11695	COG1175	transmembrane transport
E4J16_RS11705	COG3458	cephalosporin-C deacetylase activity
E4J16_RS11710	COG1609	Transcriptional regulator
E4J16_RS11715	COG4214	carbohydrate transport
E4J16_RS11725	COG4213	ABC transporter substrate-binding protein
E4J16_RS11730	COG1609	Transcriptional regulator
E4J16_RS11735	COG2017	converts alpha-aldose to the beta-anomer
E4J16_RS11750	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11755	COG1175	transmembrane transport
E4J16_RS11775	COG1609	Transcriptional regulator
E4J16_RS11780	COG2160	L-arabinose isomerase activity
E4J16_RS11805	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11810	COG4209	transmembrane transport
E4J16_RS11815	COG1653	transport
E4J16_RS11825	COG1609	Transcriptional regulator
E4J16_RS11845	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11850	COG1175	transmembrane transport
E4J16_RS11860	COG1609	Transcriptional regulator
E4J16_RS11865	COG3534	alpha-L-arabinofuranosidase
E4J16_RS11880	COG2211	Major facilitator Superfamily
E4J16_RS11890	COG2390	Transcriptional regulator
E4J16_RS11895	COG3958	Transketolase
E4J16_RS11900	COG3959	Transketolase, thiamine diphosphate binding domain
E4J16_RS11905	COG1082	Xylose isomerase domain protein TIM barrel
E4J16_RS11910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4J16_RS11915	COG1879	ABC-type sugar transport system periplasmic component
E4J16_RS11920	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4J16_RS11925	COG1129	ABC transporter
E4J16_RS11935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4J16_RS11960	COG0395	ABC-type sugar transport system, permease component
E4J16_RS11965	COG1175	transmembrane transport
E4J16_RS11980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4J16_RS11990	COG1733	regulation of RNA biosynthetic process
E4J16_RS12010	COG0395	ABC-type sugar transport system, permease component
E4J16_RS12015	COG1175	transmembrane transport
E4J16_RS12025	COG0395	ABC-type sugar transport system, permease component
E4J16_RS12030	COG4209	transmembrane transport
E4J16_RS12040	COG1609	Transcriptional regulator
E4J16_RS12045	COG4214	carbohydrate transport
E4J16_RS12095	COG1063	alcohol dehydrogenase
E4J16_RS12130	COG0395	ABC-type sugar transport system, permease component
E4J16_RS12145	COG1609	Transcriptional regulator
E4J16_RS12150	COG0698	ribose 5-phosphate isomerase
E4J16_RS12155	COG2376	Dihydroxyacetone kinase
E4J16_RS12165	COG2084	Dehydrogenase
E4J16_RS12180	COG1175	transmembrane transport
E4J16_RS12190	COG1609	Transcriptional regulator
E4J16_RS12195	COG1070	Carbohydrate kinase
E4J16_RS12200	COG2115	Belongs to the xylose isomerase family
E4J16_RS12205	COG1940	carbohydrate kinase activity
E4J16_RS12205	COG1846	Transcriptional regulator
E4J16_RS12210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4J16_RS12215	COG0800	Aldolase
E4J16_RS12220	COG1312	Catalyzes the dehydration of D-mannonate
E4J16_RS12225	COG0246	Mannitol dehydrogenase
E4J16_RS12230	COG3250	beta-galactosidase activity
E4J16_RS12235	COG1609	Transcriptional regulator
E4J16_RS12240	COG1904	glucuronate isomerase
E4J16_RS12250	COG3833	ABC-type maltose transport systems, permease component
E4J16_RS12260	COG1653	transport
E4J16_RS12265	COG1609	Transcriptional regulator
E4J16_RS12270	COG1501	Belongs to the glycosyl hydrolase 31 family
E4J16_RS12275	COG0395	ABC-type sugar transport system, permease component
E4J16_RS12280	COG1175	transmembrane transport
E4J16_RS12290	COG1609	Transcriptional regulator
E4J16_RS12305	COG0667	Aldo Keto reductase
E4J16_RS12315	COG2376	Dihydroxyacetone kinase
E4J16_RS12325	COG3775	system Galactitol-specific IIC component
E4J16_RS12375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4J16_RS12395	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E4J16_RS12410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4J16_RS12420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4J16_RS12425	COG0247	lactate metabolic process
E4J16_RS12430	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4J16_RS12435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4J16_RS12440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4J16_RS12445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4J16_RS12450	COG1620	l-lactate permease
E4J16_RS12460	COG0247	lactate metabolic process
E4J16_RS12465	COG1139	Iron-sulfur cluster binding protein
E4J16_RS12470	COG1556	Lactate utilization protein
E4J16_RS12560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4J16_RS12570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E4J16_RS12585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4J16_RS12605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4J16_RS12620	COG0302	gtp cyclohydrolase
E4J16_RS12625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4J16_RS12710	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4J16_RS12715	COG1468	defense response to virus
E4J16_RS12715	COG1518	maintenance of DNA repeat elements
E4J16_RS12735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4J16_RS12750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4J16_RS12755	COG3883	PFAM NLP P60 protein
E4J16_RS12755	COG0791	NLP P60 protein
E4J16_RS12760	COG2873	o-acetylhomoserine
E4J16_RS12765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4J16_RS12780	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4J16_RS12785	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4J16_RS12810	COG0714	Associated with various cellular activities
E4J16_RS12840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4J16_RS12840	COG0574	Belongs to the PEP-utilizing enzyme family
E4J16_RS12850	COG0438	transferase activity, transferring glycosyl groups
E4J16_RS12895	COG1490	D-aminoacyl-tRNA deacylase activity
E4J16_RS12905	COG4555	ABC transporter
E4J16_RS12945	COG3485	protocatechuate 3,4-dioxygenase
E4J16_RS12955	COG0745	RESPONSE REGULATOR receiver
E4J16_RS12960	COG2814	Major facilitator Superfamily
E4J16_RS12980	COG1136	(ABC) transporter
E4J16_RS12980	COG0577	efflux transmembrane transporter activity
E4J16_RS13040	COG3311	Transcriptional regulator
E4J16_RS13090	COG1569	PIN domain
E4J16_RS13095	COG3311	Transcriptional regulator
E4J16_RS13195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4J16_RS13200	COG1335	isochorismatase
E4J16_RS13210	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E4J16_RS13220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4J16_RS13280	COG1131	(ABC) transporter
E4J16_RS13295	COG0191	fructose-bisphosphate aldolase activity
E4J16_RS13305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4J16_RS13310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4J16_RS13320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4J16_RS13325	COG1333	cytochrome c biogenesis protein
E4J16_RS13330	COG4232	protein-disulfide reductase activity
E4J16_RS13340	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4J16_RS13350	COG4221	oxidoreductase activity
E4J16_RS13370	COG0778	Nitroreductase
E4J16_RS13375	COG2176	DNA-directed DNA polymerase activity
E4J16_RS13395	COG0717	Belongs to the dCTP deaminase family
E4J16_RS13475	COG0714	Associated with various cellular activities
E4J16_RS13510	COG5650	phosphatidylinositol metabolic process
E4J16_RS13530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4J16_RS13535	COG1132	(ABC) transporter
E4J16_RS13540	COG4988	ABC transporter
E4J16_RS13550	COG0745	RESPONSE REGULATOR receiver
E4J16_RS13555	COG2205	protein histidine kinase activity
E4J16_RS13595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4J16_RS13770	COG0629	single-stranded DNA binding
E4J16_RS13900	COG3842	ATPase activity
E4J16_RS13940	COG0215	cysteine-tRNA ligase activity
E4J16_RS13945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4J16_RS13950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4J16_RS13985	COG3716	PTS system mannose fructose sorbose family IID component
E4J16_RS13990	COG3715	PTS system
E4J16_RS14000	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4J16_RS14010	COG1621	beta-fructofuranosidase activity
E4J16_RS14050	COG1505	serine-type exopeptidase activity
E4J16_RS14065	COG0789	Transcriptional regulator
E4J16_RS14070	COG0484	heat shock protein binding
E4J16_RS14075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4J16_RS14080	COG0443	Heat shock 70 kDa protein
E4J16_RS14090	COG3655	Transcriptional regulator
E4J16_RS14145	COG1597	lipid kinase activity
E4J16_RS14165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4J16_RS14165	COG1918	ferrous iron import across plasma membrane
E4J16_RS14185	COG1136	(ABC) transporter
E4J16_RS14190	COG0535	radical SAM domain protein
E4J16_RS14195	COG3253	May function as heme-dependent peroxidase
E4J16_RS14195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4J16_RS14200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4J16_RS14205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4J16_RS14210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4J16_RS14215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4J16_RS14225	COG0181	hydroxymethylbilane synthase activity
E4J16_RS14235	COG0113	porphobilinogen synthase activity
E4J16_RS14240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4J16_RS14255	COG0783	Belongs to the Dps family
E4J16_RS14260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4J16_RS14325	COG1131	(ABC) transporter
E4J16_RS14340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4J16_RS14620	COG0582	viral genome integration into host DNA
E4J16_RS14650	COG2233	PERMEase
E4J16_RS14670	COG2267	carboxylic ester hydrolase activity
E4J16_RS14680	COG3550	peptidyl-serine autophosphorylation
E4J16_RS14710	COG1733	regulation of RNA biosynthetic process
E4J16_RS14720	COG0351	phosphomethylpyrimidine kinase
E4J16_RS14725	COG1695	Transcriptional regulator
E4J16_RS14730	COG1121	(ABC) transporter
E4J16_RS14740	COG0305	Participates in initiation and elongation during chromosome replication
E4J16_RS14745	COG0534	Mate efflux family protein
E4J16_RS14750	COG0359	binds to the 23S rRNA
E4J16_RS14755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4J16_RS14765	COG0360	Binds together with S18 to 16S ribosomal RNA
E4J16_RS14770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4J16_RS14775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4J16_RS14785	COG1609	Transcriptional regulator
E4J16_RS14790	COG0395	ABC-type sugar transport system, permease component
E4J16_RS14795	COG1175	transmembrane transport
E4J16_RS14800	COG1653	transport
E4J16_RS14810	COG2211	Major facilitator Superfamily
E4J16_RS14825	COG1874	Beta-galactosidase
E4J16_RS14830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4J16_RS14835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4J16_RS14885	COG0617	tRNA 3'-terminal CCA addition
E4J16_RS14900	COG0492	ferredoxin-NADP+ reductase activity
E4J16_RS14905	COG3118	belongs to the thioredoxin family
E4J16_RS14920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4J16_RS14925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4J16_RS14930	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4J16_RS14940	COG1192	Involved in chromosome partitioning
E4J16_RS14945	COG0357	Ribosomal RNA small subunit methyltransferase G
E4J16_RS14955	COG0706	membrane insertase activity
E4J16_RS14960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4J16_RS14965	COG0594	ribonuclease P activity
E4J16_RS14970	COG0230	Belongs to the bacterial ribosomal protein bL34 family