locus-tag	class	description
HW274_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW274_RS00010	COG0592	DNA-directed DNA polymerase activity
HW274_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW274_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HW274_RS00025	COG0187	DNA topoisomerase II activity
HW274_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW274_RS00065	COG1476	TRANSCRIPTIONal
HW274_RS00120	COG3764	Sortase (surface protein transpeptidase)
HW274_RS00135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HW274_RS00140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW274_RS00145	COG0360	Binds together with S18 to 16S ribosomal RNA
HW274_RS00155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW274_RS00160	COG0359	binds to the 23S rRNA
HW274_RS00165	COG0534	Mate efflux family protein
HW274_RS00170	COG0305	Participates in initiation and elongation during chromosome replication
HW274_RS00180	COG1121	(ABC) transporter
HW274_RS00190	COG0351	phosphomethylpyrimidine kinase
HW274_RS00200	COG1733	regulation of RNA biosynthetic process
HW274_RS00210	COG1760	l-serine dehydratase
HW274_RS00250	COG1780	Probably involved in ribonucleotide reductase function
HW274_RS00255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW274_RS00265	COG0385	Bile acid
HW274_RS00270	COG1072	(Pantothenic acid kinase))
HW274_RS00315	COG1609	Transcriptional regulator
HW274_RS00325	COG2211	Major facilitator Superfamily
HW274_RS00330	COG0672	)-iron permease
HW274_RS00340	COG2837	iron assimilation
HW274_RS00350	COG1309	transcriptional regulator
HW274_RS00370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HW274_RS00380	COG1653	transport
HW274_RS00435	COG0626	cystathionine gamma-synthase activity
HW274_RS00440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW274_RS00460	COG1937	Protein conserved in bacteria
HW274_RS00470	COG2197	response regulator
HW274_RS00520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW274_RS00545	COG2813	Specifically methylates the guanine in position
HW274_RS00560	COG1950	PFAM Membrane protein of
HW274_RS00565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW274_RS00645	COG3739	integral membrane protein
HW274_RS00655	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW274_RS00665	COG0463	Glycosyl transferase, family 2
HW274_RS00700	COG2011	ABC-type metal ion transport system permease component
HW274_RS00705	COG1464	Belongs to the NlpA lipoprotein family
HW274_RS00725	COG4585	Histidine kinase
HW274_RS00770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW274_RS00775	COG2197	response regulator
HW274_RS00800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW274_RS00805	COG0590	tRNA wobble adenosine to inosine editing
HW274_RS00805	COG0037	tRNA processing
HW274_RS00820	COG1643	Atp-dependent helicase
HW274_RS00855	COG0702	epimerase
HW274_RS00885	COG2233	PERMEase
HW274_RS00940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW274_RS00965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW274_RS00975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW274_RS00985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW274_RS00990	COG0113	porphobilinogen synthase activity
HW274_RS01005	COG3415	Transposase
HW274_RS01005	COG2801	Transposase and inactivated derivatives
HW274_RS01015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HW274_RS01020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HW274_RS01025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW274_RS01030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW274_RS01030	COG3253	May function as heme-dependent peroxidase
HW274_RS01040	COG0783	Belongs to the Dps family
HW274_RS01085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW274_RS01085	COG1918	ferrous iron import across plasma membrane
HW274_RS01105	COG1597	lipid kinase activity
HW274_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
HW274_RS01130	COG1408	metallophosphoesterase
HW274_RS01135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW274_RS01160	COG1136	(ABC) transporter
HW274_RS01160	COG0577	efflux transmembrane transporter activity
HW274_RS01170	COG2267	carboxylic ester hydrolase activity
HW274_RS01175	COG3548	integral membrane protein
HW274_RS01185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HW274_RS01235	COG0450	alkyl hydroperoxide reductase
HW274_RS01240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW274_RS01270	COG2205	protein histidine kinase activity
HW274_RS01275	COG0745	RESPONSE REGULATOR receiver
HW274_RS01290	COG1754	DNA topoisomerase type I activity
HW274_RS01290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW274_RS01300	COG0745	RESPONSE REGULATOR receiver
HW274_RS01305	COG5002	protein histidine kinase activity
HW274_RS01315	COG2885	chlorophyll binding
HW274_RS01325	COG2188	Transcriptional regulator
HW274_RS01355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW274_RS01360	COG0470	DNA polymerase III
HW274_RS01385	COG0252	asparaginase activity
HW274_RS01390	COG1113	amino acid transport
HW274_RS01405	COG0588	phosphoglycerate mutase activity
HW274_RS01415	COG5002	protein histidine kinase activity
HW274_RS01420	COG0745	RESPONSE REGULATOR receiver
HW274_RS01430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HW274_RS01460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW274_RS01475	COG1643	Atp-dependent helicase
HW274_RS01495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW274_RS01500	COG2860	membrane
HW274_RS01520	COG5650	phosphatidylinositol metabolic process
HW274_RS01555	COG0714	Associated with various cellular activities
HW274_RS01615	COG0717	Belongs to the dCTP deaminase family
HW274_RS01625	COG2176	DNA-directed DNA polymerase activity
HW274_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
HW274_RS01650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW274_RS01655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HW274_RS01660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW274_RS01665	COG0191	fructose-bisphosphate aldolase activity
HW274_RS01695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HW274_RS01725	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HW274_RS01775	COG0151	Belongs to the GarS family
HW274_RS01780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW274_RS01800	COG0047	phosphoribosylformylglycinamidine synthase activity
HW274_RS01825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW274_RS01855	COG1090	epimerase
HW274_RS01865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW274_RS01870	COG4085	toxin activity
HW274_RS01870	COG1525	nuclease
HW274_RS01870	COG0737	Belongs to the 5'-nucleotidase family
HW274_RS01875	COG1349	DNA-binding transcription factor activity
HW274_RS01885	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HW274_RS01885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW274_RS01885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW274_RS01895	COG0557	exoribonuclease II activity
HW274_RS01900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW274_RS01905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HW274_RS01930	COG1132	(ABC) transporter
HW274_RS01935	COG1132	(ABC) transporter
HW274_RS01940	COG0577	efflux transmembrane transporter activity
HW274_RS01945	COG1136	(ABC) transporter
HW274_RS01955	COG1472	Belongs to the glycosyl hydrolase 3 family
HW274_RS01995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW274_RS02005	COG0679	Auxin Efflux Carrier
HW274_RS02015	COG1722	exodeoxyribonuclease VII activity
HW274_RS02025	COG0477	Major facilitator Superfamily
HW274_RS02030	COG1570	exodeoxyribonuclease VII activity
HW274_RS02035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW274_RS02040	COG0833	amino acid
HW274_RS02055	COG1595	DNA-templated transcription, initiation
HW274_RS02085	COG2261	transglycosylase associated protein
HW274_RS02090	COG1322	Protein conserved in bacteria
HW274_RS02100	COG0012	GTP binding
HW274_RS02155	COG4115	mRNA cleavage
HW274_RS02165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW274_RS02170	COG2873	o-acetylhomoserine
HW274_RS02180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HW274_RS02185	COG2027	D-alanyl-D-alanine carboxypeptidase
HW274_RS02195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HW274_RS02210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_RS02215	COG0302	gtp cyclohydrolase
HW274_RS02230	COG2076	Multidrug Resistance protein
HW274_RS02240	COG2197	response regulator
HW274_RS02245	COG0577	efflux transmembrane transporter activity
HW274_RS02245	COG1136	(ABC) transporter
HW274_RS02250	COG1136	(ABC) transporter
HW274_RS02255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW274_RS02260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW274_RS02285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW274_RS02290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HW274_RS02295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HW274_RS02300	COG1917	Cupin 2, conserved barrel domain protein
HW274_RS02300	COG2207	Transcriptional regulator
HW274_RS02320	COG3599	regulation of cell shape
HW274_RS02335	COG1136	(ABC) transporter
HW274_RS02345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS02350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS02355	COG1120	ATPase activity
HW274_RS02360	COG4592	Periplasmic binding protein
HW274_RS02370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW274_RS02400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW274_RS02410	COG3104	oligopeptide transport
HW274_RS02415	COG3104	oligopeptide transport
HW274_RS02430	COG1556	Lactate utilization protein
HW274_RS02435	COG1139	Iron-sulfur cluster binding protein
HW274_RS02440	COG0247	lactate metabolic process
HW274_RS02460	COG1620	l-lactate permease
HW274_RS02470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HW274_RS02475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW274_RS02480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW274_RS02490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HW274_RS02520	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HW274_RS02540	COG2814	Major facilitator Superfamily
HW274_RS02565	COG2376	Dihydroxyacetone kinase
HW274_RS02570	COG1461	Dihydroxyacetone kinase
HW274_RS02595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW274_RS02610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW274_RS02615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HW274_RS02630	COG0436	Aminotransferase
HW274_RS02640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW274_RS02645	COG0250	Participates in transcription elongation, termination and antitermination
HW274_RS02650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW274_RS02655	COG0081	regulation of translation
HW274_RS02660	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_RS02675	COG2885	chlorophyll binding
HW274_RS02675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW274_RS02730	COG3850	Histidine kinase
HW274_RS02735	COG2197	response regulator
HW274_RS02780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW274_RS02785	COG0049	tRNA binding
HW274_RS02790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW274_RS02795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW274_RS02815	COG0051	transcription antitermination factor activity, RNA binding
HW274_RS02830	COG0089	rRNA binding
HW274_RS02835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW274_RS02840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW274_RS02845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW274_RS02850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HW274_RS02855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW274_RS02860	COG0255	Belongs to the universal ribosomal protein uL29 family
HW274_RS02865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW274_RS02875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW274_RS02880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HW274_RS02885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW274_RS02890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW274_RS02895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HW274_RS02900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HW274_RS02905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW274_RS02910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW274_RS02915	COG1841	ribosomal large subunit assembly
HW274_RS02930	COG0563	adenylate kinase activity
HW274_RS02935	COG0024	Methionine aminopeptidase
HW274_RS02940	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_RS02945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW274_RS02950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW274_RS02955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW274_RS02960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HW274_RS02965	COG0202	RNA polymerase activity
HW274_RS02980	COG1285	pathogenesis
HW274_RS02990	COG0101	tRNA pseudouridine synthase activity
HW274_RS02995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW274_RS03000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW274_RS03030	COG1395	domain, Protein
HW274_RS03035	COG0596	Alpha beta hydrolase
HW274_RS03040	COG1072	(Pantothenic acid kinase))
HW274_RS03050	COG0736	holo-[acyl-carrier-protein] synthase activity
HW274_RS03060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HW274_RS03065	COG0802	atpase or kinase
HW274_RS03090	COG1053	succinate dehydrogenase
HW274_RS03095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW274_RS03100	COG0546	phosphoglycolate phosphatase activity
HW274_RS03105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HW274_RS03115	COG2375	cellular response to nickel ion
HW274_RS03115	COG1132	(ABC) transporter
HW274_RS03125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HW274_RS03135	COG2949	membrane
HW274_RS03140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW274_RS03160	COG0516	GMP reductase activity
HW274_RS03165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW274_RS03170	COG4975	Glucose uptake
HW274_RS03205	COG0328	RNA-DNA hybrid ribonuclease activity
HW274_RS03215	COG2197	response regulator
HW274_RS03220	COG4585	Histidine kinase
HW274_RS03235	COG1131	(ABC) transporter
HW274_RS03240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW274_RS03270	COG1082	Xylose isomerase domain protein TIM barrel
HW274_RS03275	COG2814	Major facilitator Superfamily
HW274_RS03280	COG0673	inositol 2-dehydrogenase activity
HW274_RS03290	COG2017	converts alpha-aldose to the beta-anomer
HW274_RS03295	COG0673	inositol 2-dehydrogenase activity
HW274_RS03300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW274_RS03305	COG2188	Transcriptional regulator
HW274_RS03320	COG3718	enzyme involved in inositol metabolism
HW274_RS03325	COG3962	Belongs to the TPP enzyme family
HW274_RS03340	COG0673	inositol 2-dehydrogenase activity
HW274_RS03345	COG1082	Xylose isomerase domain protein TIM barrel
HW274_RS03350	COG2814	Major facilitator Superfamily
HW274_RS03375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW274_RS03375	COG0519	Catalyzes the synthesis of GMP from XMP
HW274_RS03390	COG1131	(ABC) transporter
HW274_RS03395	COG4585	Histidine kinase
HW274_RS03425	COG2267	carboxylic ester hydrolase activity
HW274_RS03435	COG1401	restriction endodeoxyribonuclease activity
HW274_RS03440	COG4268	DNA restriction-modification system
HW274_RS03470	COG2205	protein histidine kinase activity
HW274_RS03475	COG2197	response regulator
HW274_RS03485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW274_RS03495	COG0356	it plays a direct role in the translocation of protons across the membrane
HW274_RS03505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW274_RS03510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW274_RS03515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW274_RS03520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW274_RS03525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW274_RS03530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW274_RS03540	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HW274_RS03550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW274_RS03560	COG2801	Transposase and inactivated derivatives
HW274_RS03580	COG3321	synthase
HW274_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
HW274_RS03580	COG0604	alcohol dehydrogenase
HW274_RS03585	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW274_RS03595	COG1960	acyl-CoA dehydrogenase activity
HW274_RS03615	COG0318	PFAM AMP-dependent synthetase and ligase
HW274_RS03640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HW274_RS03645	COG0830	nickel cation binding
HW274_RS03655	COG0804	urea catabolic process
HW274_RS03660	COG0832	Belongs to the urease beta subunit family
HW274_RS03670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW274_RS03675	COG0254	rRNA binding
HW274_RS03680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW274_RS03685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW274_RS03690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW274_RS03700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HW274_RS03705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW274_RS03710	COG1621	beta-fructofuranosidase activity
HW274_RS03730	COG1254	Belongs to the acylphosphatase family
HW274_RS03740	COG1136	(ABC) transporter
HW274_RS03740	COG0577	efflux transmembrane transporter activity
HW274_RS03745	COG1136	(ABC) transporter
HW274_RS03745	COG0577	efflux transmembrane transporter activity
HW274_RS03755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW274_RS03760	COG1349	DNA-binding transcription factor activity
HW274_RS03780	COG1744	ABC transporter substrate-binding protein PnrA-like
HW274_RS03785	COG3845	ABC transporter
HW274_RS03790	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW274_RS03795	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW274_RS03825	COG0803	Belongs to the bacterial solute-binding protein 9 family
HW274_RS03830	COG1121	(ABC) transporter
HW274_RS03845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW274_RS03850	COG1611	Belongs to the LOG family
HW274_RS03865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW274_RS03880	COG2239	Acts as a magnesium transporter
HW274_RS03890	COG1082	Xylose isomerase domain protein TIM barrel
HW274_RS03905	COG0006	proline dipeptidase activity
HW274_RS03910	COG0673	inositol 2-dehydrogenase activity
HW274_RS03920	COG2095	MarC family integral membrane protein
HW274_RS03925	COG0513	Belongs to the DEAD box helicase family
HW274_RS03970	COG0114	fumarate hydratase activity
HW274_RS03990	COG0346	lactoylglutathione lyase activity
HW274_RS04000	COG1174	glycine betaine transport
HW274_RS04020	COG1733	regulation of RNA biosynthetic process
HW274_RS04030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HW274_RS04060	COG1674	ftsk spoiiie
HW274_RS04065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW274_RS04075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW274_RS04080	COG0154	amidase activity
HW274_RS04085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW274_RS04115	COG2966	Psort location CytoplasmicMembrane, score
HW274_RS04120	COG0569	domain protein
HW274_RS04120	COG2985	domain, Protein
HW274_RS04135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HW274_RS04150	COG0473	3-isopropylmalate dehydrogenase activity
HW274_RS04165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW274_RS04170	COG1316	TRANSCRIPTIONal
HW274_RS04175	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW274_RS04180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HW274_RS04185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW274_RS04205	COG1216	Glycosyl transferase, family 2
HW274_RS04215	COG1134	teichoic acid transport
HW274_RS04235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW274_RS04245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW274_RS04265	COG0515	serine threonine protein kinase
HW274_RS04270	COG1716	ATPase activity
HW274_RS04270	COG1131	(ABC) transporter
HW274_RS04270	COG0842	Transport permease protein
HW274_RS04280	COG1162	GTPase activity
HW274_RS04285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW274_RS04290	COG0629	single-stranded DNA binding
HW274_RS04300	COG2884	Cell division ATP-binding protein ftsE
HW274_RS04365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_RS04400	COG0747	negative chemotaxis
HW274_RS04410	COG0444	Belongs to the ABC transporter superfamily
HW274_RS04415	COG4608	Belongs to the ABC transporter superfamily
HW274_RS04430	COG1175	transmembrane transport
HW274_RS04440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW274_RS04445	COG1940	carbohydrate kinase activity
HW274_RS04450	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HW274_RS04470	COG0363	glucosamine-6-phosphate deaminase activity
HW274_RS04490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HW274_RS04500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HW274_RS04520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW274_RS04525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HW274_RS04585	COG3304	Inner membrane component domain
HW274_RS04590	COG0833	amino acid
HW274_RS04595	COG2040	homocysteine
HW274_RS04615	COG1115	amino acid carrier protein
HW274_RS04620	COG1115	amino acid carrier protein
HW274_RS04625	COG1115	amino acid carrier protein
HW274_RS04630	COG1115	amino acid carrier protein
HW274_RS04635	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW274_RS04645	COG2801	Transposase and inactivated derivatives
HW274_RS04645	COG3415	Transposase
HW274_RS04650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW274_RS04685	COG0726	polysaccharide deacetylase
HW274_RS04690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW274_RS04700	COG1674	ftsk spoiiie
HW274_RS04715	COG1546	Belongs to the CinA family
HW274_RS04715	COG1058	Belongs to the CinA family
HW274_RS04720	COG1396	sequence-specific DNA binding
HW274_RS04730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW274_RS04735	COG2137	regulation of response to DNA damage stimulus
HW274_RS04745	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HW274_RS04755	COG0395	ABC-type sugar transport system, permease component
HW274_RS04770	COG1846	Transcriptional regulator
HW274_RS04770	COG1940	carbohydrate kinase activity
HW274_RS04775	COG1252	NADH dehydrogenase
HW274_RS04780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW274_RS04805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW274_RS04810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HW274_RS04815	COG1114	Component of the transport system for branched-chain amino acids
HW274_RS04825	COG2813	Specifically methylates the guanine in position
HW274_RS04840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW274_RS04855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW274_RS04865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW274_RS04880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HW274_RS04885	COG0066	3-isopropylmalate dehydratase activity
HW274_RS04890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW274_RS04900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HW274_RS04905	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW274_RS04915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW274_RS04920	COG1461	Dihydroxyacetone kinase
HW274_RS04935	COG0235	Class ii aldolase
HW274_RS04945	COG1070	Carbohydrate kinase
HW274_RS04950	COG4154	Belongs to the RbsD FucU family
HW274_RS04955	COG0738	Major facilitator superfamily
HW274_RS04965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW274_RS04980	COG0571	ribonuclease III activity
HW274_RS04985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW274_RS05000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HW274_RS05005	COG4988	ABC transporter
HW274_RS05010	COG1294	oxidase, subunit
HW274_RS05015	COG1271	oxidase subunit
HW274_RS05020	COG1530	ribonuclease E activity
HW274_RS05025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HW274_RS05030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HW274_RS05035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW274_RS05040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW274_RS05045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW274_RS05055	COG0745	RESPONSE REGULATOR receiver
HW274_RS05060	COG5002	protein histidine kinase activity
HW274_RS05065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW274_RS05080	COG1132	(ABC) transporter
HW274_RS05085	COG0297	glycogen (starch) synthase activity
HW274_RS05095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW274_RS05100	COG1349	DNA-binding transcription factor activity
HW274_RS05110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW274_RS05120	COG0799	negative regulation of ribosome biogenesis
HW274_RS05125	COG0406	alpha-ribazole phosphatase activity
HW274_RS05140	COG2095	MarC family integral membrane protein
HW274_RS05155	COG0813	purine-nucleoside phosphorylase activity
HW274_RS05160	COG0733	neurotransmitter:sodium symporter activity
HW274_RS05195	COG0537	adenosine 5'-monophosphoramidase activity
HW274_RS05210	COG0789	Transcriptional regulator
HW274_RS05215	COG0495	leucyl-tRNA aminoacylation
HW274_RS05220	COG0433	COG0433 Predicted ATPase
HW274_RS05225	COG0438	transferase activity, transferring glycosyl groups
HW274_RS05230	COG1307	EDD domain protein, DegV family
HW274_RS05235	COG1555	photosystem II stabilization
HW274_RS05250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW274_RS05255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW274_RS05255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW274_RS05270	COG4868	Belongs to the UPF0371 family
HW274_RS05275	COG0268	Binds directly to 16S ribosomal RNA
HW274_RS05295	COG0159	tryptophan synthase activity
HW274_RS05310	COG0512	Glutamine amidotransferase of anthranilate synthase
HW274_RS05315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW274_RS05320	COG1404	Belongs to the peptidase S8 family
HW274_RS05335	COG0481	GTPase activity
HW274_RS05345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW274_RS05350	COG2807	transmembrane transport
HW274_RS05360	COG1673	EVE domain
HW274_RS05380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW274_RS05395	COG1420	regulation of RNA biosynthetic process
HW274_RS05400	COG0484	heat shock protein binding
HW274_RS05405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW274_RS05435	COG0842	Transport permease protein
HW274_RS05455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HW274_RS05465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HW274_RS05470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW274_RS05470	COG0506	proline dehydrogenase activity
HW274_RS05470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW274_RS05475	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW274_RS05480	COG1476	TRANSCRIPTIONal
HW274_RS05490	COG1131	(ABC) transporter
HW274_RS05495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW274_RS05500	COG1381	Involved in DNA repair and RecF pathway recombination
HW274_RS05505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW274_RS05515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW274_RS05530	COG0423	glycine-tRNA ligase activity
HW274_RS05555	COG0560	Phosphoserine phosphatase
HW274_RS05565	COG0297	glycogen (starch) synthase activity
HW274_RS05575	COG1122	ATPase activity
HW274_RS05605	COG0488	(ABC) transporter
HW274_RS05615	COG0545	Peptidyl-prolyl cis-trans isomerase
HW274_RS05645	COG0205	6-phosphofructokinase activity
HW274_RS05650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HW274_RS05655	COG2815	serine threonine protein kinase
HW274_RS05655	COG0515	serine threonine protein kinase
HW274_RS05660	COG0142	geranyltranstransferase activity
HW274_RS05665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW274_RS05690	COG0187	DNA topoisomerase II activity
HW274_RS05695	COG0456	acetyltransferase
HW274_RS05695	COG0454	-acetyltransferase
HW274_RS05705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW274_RS05750	COG0569	domain protein
HW274_RS05755	COG0531	amino acid
HW274_RS05760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW274_RS05765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW274_RS05775	COG1309	transcriptional regulator
HW274_RS05780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW274_RS05795	COG4555	ABC transporter
HW274_RS05810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW274_RS05815	COG4221	oxidoreductase activity
HW274_RS05820	COG1881	PFAM PEBP family protein
HW274_RS05835	COG0671	phosphoesterase, PA-phosphatase related
HW274_RS05860	COG0587	DNA-directed DNA polymerase activity
HW274_RS05885	COG3152	Membrane
HW274_RS05905	COG0477	Major facilitator Superfamily
HW274_RS05915	COG0028	Belongs to the TPP enzyme family
HW274_RS05920	COG0339	signal peptide processing
HW274_RS05925	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW274_RS05935	COG4607	ABC-type enterochelin transport system periplasmic component
HW274_RS05940	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS05945	COG4605	iron ion homeostasis
HW274_RS05950	COG4604	ABC transporter, ATP-binding protein
HW274_RS05955	COG0667	Aldo Keto reductase
HW274_RS05960	COG0425	Belongs to the sulfur carrier protein TusA family
HW274_RS05965	COG2391	methyltransferase activity
HW274_RS05975	COG1994	Peptidase M50
HW274_RS05975	COG0517	IMP dehydrogenase activity
HW274_RS05980	COG2837	iron assimilation
HW274_RS05995	COG1222	aaa ATPase
HW274_RS06010	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HW274_RS06020	COG0107	imidazoleglycerol-phosphate synthase activity
HW274_RS06045	COG0134	indole-3-glycerol-phosphate synthase activity
HW274_RS06075	COG2050	protein possibly involved in aromatic compounds catabolism
HW274_RS06085	COG0539	negative regulation of cytoplasmic translation
HW274_RS06095	COG0237	dephospho-CoA kinase activity
HW274_RS06100	COG0556	nucleotide-excision repair
HW274_RS06115	COG2226	methyltransferase
HW274_RS06160	COG0322	excinuclease ABC activity
HW274_RS06165	COG3585	molybdate ion transport
HW274_RS06175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HW274_RS06180	COG1660	Displays ATPase and GTPase activities
HW274_RS06190	COG1481	regulation of sporulation
HW274_RS06195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW274_RS06200	COG0126	phosphoglycerate kinase activity
HW274_RS06205	COG0149	triose-phosphate isomerase activity
HW274_RS06210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW274_RS06230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW274_RS06245	COG1160	GTP binding
HW274_RS06265	COG0166	Belongs to the GPI family
HW274_RS06270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW274_RS06300	COG0363	glucosamine-6-phosphate deaminase activity
HW274_RS06315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW274_RS06325	COG1716	ATPase activity
HW274_RS06345	COG0667	Aldo Keto reductase
HW274_RS06350	COG0443	Heat shock 70 kDa protein
HW274_RS06365	COG1621	beta-fructofuranosidase activity
HW274_RS06370	COG1263	PTS System
HW274_RS06370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_RS06370	COG2190	(PTS) system
HW274_RS06375	COG1609	Transcriptional regulator
HW274_RS06385	COG1136	(ABC) transporter
HW274_RS06390	COG0577	efflux transmembrane transporter activity
HW274_RS06395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW274_RS06405	COG0205	6-phosphofructokinase activity
HW274_RS06415	COG1216	Glycosyl transferase, family 2
HW274_RS06420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HW274_RS06425	COG2354	Protein conserved in bacteria
HW274_RS06440	COG0805	protein transport
HW274_RS06465	COG4585	Histidine kinase
HW274_RS06470	COG2197	response regulator
HW274_RS06475	COG1131	(ABC) transporter
HW274_RS06495	COG0140	phosphoribosyl-ATP diphosphatase activity
HW274_RS06500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HW274_RS06505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW274_RS06510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW274_RS06515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW274_RS06525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW274_RS06530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW274_RS06535	COG4770	biotin carboxylase activity
HW274_RS06540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW274_RS06550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW274_RS06565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW274_RS06570	COG0549	Belongs to the carbamate kinase family
HW274_RS06575	COG1834	amidinotransferase
HW274_RS06600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW274_RS06610	COG1758	RNA polymerase activity
HW274_RS06615	COG0194	GDP metabolic process
HW274_RS06625	COG0284	orotidine-5'-phosphate decarboxylase activity
HW274_RS06630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW274_RS06640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW274_RS06645	COG0540	Belongs to the ATCase OTCase family
HW274_RS06650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HW274_RS06670	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_RS06675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW274_RS06680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW274_RS06685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW274_RS06690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW274_RS06695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HW274_RS06700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW274_RS06710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HW274_RS06715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW274_RS06720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW274_RS06730	COG0009	L-threonylcarbamoyladenylate synthase
HW274_RS06755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW274_RS06785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW274_RS06785	COG1116	anion transmembrane transporter activity
HW274_RS06815	COG0124	histidyl-tRNA synthetase
HW274_RS06825	COG0488	(ABC) transporter
HW274_RS06830	COG1196	nuclear chromosome segregation
HW274_RS06835	COG0789	Transcriptional regulator
HW274_RS06845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW274_RS06850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW274_RS06855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW274_RS06860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW274_RS06870	COG2255	four-way junction helicase activity
HW274_RS06875	COG0632	four-way junction helicase activity
HW274_RS06880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HW274_RS06885	COG0217	transcriptional regulatory protein
HW274_RS06890	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW274_RS06895	COG1051	belongs to the nudix hydrolase family
HW274_RS06900	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HW274_RS06915	COG0438	transferase activity, transferring glycosyl groups
HW274_RS06935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW274_RS06995	COG1882	Formate acetyltransferase
HW274_RS07005	COG1073	alpha beta
HW274_RS07010	COG0038	chloride channel
HW274_RS07020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW274_RS07025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW274_RS07030	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW274_RS07060	COG0321	lipoyl(octanoyl) transferase activity
HW274_RS07065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HW274_RS07085	COG0765	amino acid transport
HW274_RS07100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HW274_RS07105	COG0174	glutamine synthetase
HW274_RS07110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HW274_RS07130	COG3022	response to hydroperoxide
HW274_RS07140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW274_RS07155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW274_RS07345	COG0436	Aminotransferase
HW274_RS07375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HW274_RS07385	COG1027	Aspartate ammonia-lyase
HW274_RS07395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW274_RS07425	COG0358	DNA primase activity
HW274_RS07440	COG3415	Transposase
HW274_RS07440	COG2801	Transposase and inactivated derivatives
HW274_RS07445	COG2182	Extracellular solute-binding protein
HW274_RS07450	COG1175	transmembrane transport
HW274_RS07455	COG3833	ABC-type maltose transport systems, permease component
HW274_RS07460	COG1609	Transcriptional regulator
HW274_RS07470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW274_RS07480	COG0167	dihydroorotate dehydrogenase activity
HW274_RS07500	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW274_RS07515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW274_RS07530	COG3189	MarR family transcriptional regulator
HW274_RS07535	COG2151	metal-sulfur cluster biosynthetic enzyme
HW274_RS07540	COG0822	iron-sulfur transferase activity
HW274_RS07550	COG0396	ATPase activity
HW274_RS07570	COG0494	nUDIX hydrolase
HW274_RS07600	COG0497	DNA recombination
HW274_RS07605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW274_RS07620	COG0647	UMP catabolic process
HW274_RS07645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HW274_RS07665	COG2094	Belongs to the DNA glycosylase MPG family
HW274_RS07670	COG0165	Argininosuccinate lyase
HW274_RS07675	COG2116	formate transmembrane transporter activity
HW274_RS07680	COG0137	argininosuccinate synthase activity
HW274_RS07685	COG1438	arginine binding
HW274_RS07690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW274_RS07695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW274_RS07705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW274_RS07720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW274_RS07730	COG1131	(ABC) transporter
HW274_RS07750	COG0765	amino acid transport
HW274_RS07755	COG0765	amino acid transport
HW274_RS07760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW274_RS07765	COG1126	abc transporter atp-binding protein
HW274_RS07780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW274_RS07785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW274_RS07790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW274_RS07795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HW274_RS07805	COG1122	ATPase activity
HW274_RS07820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HW274_RS07825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW274_RS07840	COG0131	Imidazoleglycerol-phosphate dehydratase
HW274_RS07850	COG0025	NhaP-type Na H and K H
HW274_RS07855	COG0514	ATP-dependent DNA helicase (RecQ)
HW274_RS07870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW274_RS07880	COG1215	transferase activity, transferring glycosyl groups
HW274_RS07890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW274_RS07895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW274_RS07915	COG2501	S4 domain
HW274_RS07920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW274_RS07925	COG0587	DNA-directed DNA polymerase activity
HW274_RS07930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW274_RS07945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW274_RS07950	COG3599	regulation of cell shape
HW274_RS07960	COG1799	cell septum assembly
HW274_RS07965	COG1496	oxidoreductase activity
HW274_RS07970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW274_RS07980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW274_RS07995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW274_RS08000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW274_RS08005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW274_RS08010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW274_RS08015	COG0768	penicillin binding
HW274_RS08025	COG0275	rRNA processing
HW274_RS08030	COG2001	Belongs to the MraZ family
HW274_RS08040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW274_RS08060	COG0318	PFAM AMP-dependent synthetase and ligase
HW274_RS08065	COG0318	PFAM AMP-dependent synthetase and ligase
HW274_RS08085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HW274_RS08095	COG0300	oxidoreductase activity
HW274_RS08100	COG0612	Peptidase, M16
HW274_RS08105	COG1185	polyribonucleotide nucleotidyltransferase activity
HW274_RS08115	COG0196	riboflavin kinase activity
HW274_RS08125	COG1136	(ABC) transporter
HW274_RS08125	COG0577	efflux transmembrane transporter activity
HW274_RS08135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW274_RS08140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HW274_RS08150	COG0330	HflC and HflK could
HW274_RS08170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW274_RS08205	COG0442	prolyl-tRNA aminoacylation
HW274_RS08240	COG0456	acetyltransferase
HW274_RS08245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HW274_RS08250	COG0750	zinc metalloprotease
HW274_RS08255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HW274_RS08265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HW274_RS08275	COG0233	cytoplasmic translational termination
HW274_RS08285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HW274_RS08290	COG0052	Belongs to the universal ribosomal protein uS2 family
HW274_RS08300	COG4974	Belongs to the 'phage' integrase family
HW274_RS08320	COG1716	ATPase activity
HW274_RS08345	COG0792	nuclease activity
HW274_RS08355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW274_RS08360	COG0681	Belongs to the peptidase S26 family
HW274_RS08370	COG0681	Belongs to the peptidase S26 family
HW274_RS08375	COG0336	Belongs to the RNA methyltransferase TrmD family
HW274_RS08380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW274_RS08385	COG1837	Belongs to the UPF0109 family
HW274_RS08405	COG1131	(ABC) transporter
HW274_RS08415	COG1131	(ABC) transporter
HW274_RS08425	COG4585	Histidine kinase
HW274_RS08430	COG2197	response regulator
HW274_RS08440	COG1131	(ABC) transporter
HW274_RS08445	COG0842	Transport permease protein
HW274_RS08450	COG4585	Histidine kinase
HW274_RS08455	COG2197	response regulator
HW274_RS08470	COG1196	nuclear chromosome segregation
HW274_RS08475	COG4152	abc transporter atp-binding protein
HW274_RS08485	COG0105	UTP biosynthetic process
HW274_RS08490	COG1461	Dihydroxyacetone kinase
HW274_RS08495	COG0285	dihydrofolate synthase activity
HW274_RS08500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW274_RS08530	COG1215	transferase activity, transferring glycosyl groups
HW274_RS08535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW274_RS08540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW274_RS08565	COG0656	L-ascorbic acid biosynthetic process
HW274_RS08575	COG4221	oxidoreductase activity
HW274_RS08580	COG2056	Na+-H+ antiporter family
HW274_RS08585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW274_RS08590	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW274_RS08595	COG0175	sulfate reduction
HW274_RS08610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HW274_RS08610	COG1648	precorrin-2 dehydrogenase activity
HW274_RS08615	COG0730	response to heat
HW274_RS08645	COG2375	cellular response to nickel ion
HW274_RS08645	COG1132	(ABC) transporter
HW274_RS08650	COG1122	ATPase activity
HW274_RS08660	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HW274_RS08670	COG4122	O-methyltransferase activity
HW274_RS08675	COG1222	aaa ATPase
HW274_RS08690	COG0454	-acetyltransferase
HW274_RS08695	COG1609	Transcriptional regulator
HW274_RS08700	COG0366	Alpha amylase catalytic
HW274_RS08730	COG0287	Prephenate dehydrogenase
HW274_RS08730	COG1605	Chorismate mutase
HW274_RS08735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HW274_RS08740	COG0740	serine-type endopeptidase activity
HW274_RS08760	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW274_RS08780	COG1739	Uncharacterized protein family UPF0029
HW274_RS08790	COG1045	serine acetyltransferase
HW274_RS08805	COG0698	ribose 5-phosphate isomerase
HW274_RS08810	COG3590	peptidase
HW274_RS08835	COG1263	PTS System
HW274_RS08840	COG2188	Transcriptional regulator
HW274_RS08845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_RS08860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_RS08865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW274_RS08905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW274_RS08980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HW274_RS08985	COG2326	polyphosphate kinase activity
HW274_RS09005	COG1615	UPF0182 protein
HW274_RS09020	COG3480	Lon protease (S16) C-terminal proteolytic domain
HW274_RS09045	COG1104	cysteine desulfurase activity
HW274_RS09060	COG0482	sulfurtransferase activity
HW274_RS09070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW274_RS09115	COG0180	Tryptophanyl-tRNA synthetase
HW274_RS09120	COG0366	Alpha amylase catalytic
HW274_RS09130	COG3281	Trehalose synthase
HW274_RS09135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HW274_RS09140	COG0058	SHG alpha-glucan phosphorylase activity
HW274_RS09175	COG0395	ABC-type sugar transport system, permease component
HW274_RS09180	COG1175	transmembrane transport
HW274_RS09190	COG0039	L-malate dehydrogenase activity
HW274_RS09200	COG1132	(ABC) transporter
HW274_RS09205	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HW274_RS09235	COG0045	succinate-CoA ligase (ADP-forming) activity
HW274_RS09250	COG0205	6-phosphofructokinase activity
HW274_RS09265	COG0778	Nitroreductase
HW274_RS09270	COG0366	Alpha amylase catalytic
HW274_RS09275	COG1501	Belongs to the glycosyl hydrolase 31 family
HW274_RS09280	COG0110	maltose O-acetyltransferase activity
HW274_RS09315	COG0604	alcohol dehydrogenase
HW274_RS09320	COG1846	Transcriptional regulator
HW274_RS09330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW274_RS09335	COG0254	rRNA binding
HW274_RS09350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW274_RS09355	COG0083	homoserine kinase activity
HW274_RS09360	COG0460	homoserine dehydrogenase
HW274_RS09375	COG0019	diaminopimelate decarboxylase activity
HW274_RS09380	COG0018	arginyl-trna synthetase
HW274_RS09395	COG0739	heme binding
HW274_RS09405	COG1253	flavin adenine dinucleotide binding
HW274_RS09410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW274_RS09410	COG0567	Dehydrogenase, E1 component
HW274_RS09425	COG1595	DNA-templated transcription, initiation
HW274_RS09435	COG2838	Isocitrate dehydrogenase
HW274_RS09440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW274_RS09445	COG1162	GTPase activity
HW274_RS09475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HW274_RS09485	COG0314	molybdopterin synthase activity
HW274_RS09495	COG0315	cyclic pyranopterin monophosphate synthase activity
HW274_RS09505	COG0315	cyclic pyranopterin monophosphate synthase activity
HW274_RS09505	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW274_RS09520	COG1140	nitrate reductase beta subunit
HW274_RS09545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW274_RS09550	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS09555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS09565	COG1120	ATPase activity
HW274_RS09575	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW274_RS09580	COG0456	acetyltransferase
HW274_RS09585	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW274_RS09590	COG0483	inositol monophosphate 1-phosphatase activity
HW274_RS09595	COG1968	undecaprenyl-diphosphatase activity
HW274_RS09610	COG0420	3'-5' exonuclease activity
HW274_RS09615	COG0419	ATPase involved in DNA repair
HW274_RS09645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HW274_RS09650	COG0085	RNA polymerase activity
HW274_RS09660	COG0222	ribosome binding
HW274_RS09665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW274_RS09705	COG0653	protein targeting
HW274_RS09715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW274_RS09725	COG5000	phosphorelay sensor kinase activity
HW274_RS09725	COG5002	protein histidine kinase activity
HW274_RS09730	COG0745	RESPONSE REGULATOR receiver
HW274_RS09750	COG0714	Associated with various cellular activities
HW274_RS09755	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HW274_RS09770	COG2835	tetraacyldisaccharide 4'-kinase activity
HW274_RS09805	COG1482	cell wall glycoprotein biosynthetic process
HW274_RS09830	COG0438	transferase activity, transferring glycosyl groups
HW274_RS09835	COG0438	transferase activity, transferring glycosyl groups
HW274_RS09890	COG0463	Glycosyl transferase, family 2
HW274_RS09905	COG1088	dTDP-glucose 4,6-dehydratase activity
HW274_RS09920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW274_RS09935	COG0297	glycogen (starch) synthase activity
HW274_RS09950	COG0438	transferase activity, transferring glycosyl groups
HW274_RS09970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW274_RS09975	COG0438	transferase activity, transferring glycosyl groups
HW274_RS10000	COG1316	TRANSCRIPTIONal
HW274_RS10005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW274_RS10035	COG5002	protein histidine kinase activity
HW274_RS10040	COG0745	RESPONSE REGULATOR receiver
HW274_RS10055	COG0424	maF-like protein
HW274_RS10070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW274_RS10090	COG1666	GTP binding
HW274_RS10095	COG2197	response regulator
HW274_RS10115	COG0501	Belongs to the peptidase M48B family
HW274_RS10120	COG0456	acetyltransferase
HW274_RS10135	COG0142	geranyltranstransferase activity
HW274_RS10150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW274_RS10155	COG0713	ATP synthesis coupled electron transport
HW274_RS10170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HW274_RS10175	COG1034	ATP synthesis coupled electron transport
HW274_RS10180	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HW274_RS10190	COG0649	NAD binding
HW274_RS10195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW274_RS10200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW274_RS10210	COG0644	oxidoreductase
HW274_RS10215	COG2226	methyltransferase
HW274_RS10220	COG1169	isochorismate synthase
HW274_RS10225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW274_RS10230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HW274_RS10235	COG4948	Mandelate Racemase Muconate Lactonizing
HW274_RS10255	COG4176	ABC-type proline glycine betaine transport system permease component
HW274_RS10265	COG1940	carbohydrate kinase activity
HW274_RS10270	COG5426	von Willebrand factor, type A
HW274_RS10280	COG1175	transmembrane transport
HW274_RS10285	COG0395	ABC-type sugar transport system, permease component
HW274_RS10300	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW274_RS10305	COG2235	arginine
HW274_RS10320	COG2197	response regulator
HW274_RS10325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW274_RS10365	COG1397	ADP-ribosylglycohydrolase
HW274_RS10370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW274_RS10390	COG0406	alpha-ribazole phosphatase activity
HW274_RS10395	COG2171	N-acyltransferase activity
HW274_RS10405	COG1053	succinate dehydrogenase
HW274_RS10425	COG2814	Major facilitator Superfamily
HW274_RS10465	COG1217	gtp-binding protein TYPA
HW274_RS10505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW274_RS10510	COG0601	transmembrane transport
HW274_RS10520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW274_RS10530	COG2267	carboxylic ester hydrolase activity
HW274_RS10545	COG1902	pentaerythritol trinitrate reductase activity
HW274_RS10550	COG1733	regulation of RNA biosynthetic process
HW274_RS10555	COG0604	alcohol dehydrogenase
HW274_RS10560	COG3012	SEC-C Motif Domain Protein
HW274_RS10565	COG1362	aminopeptidase activity
HW274_RS10570	COG0546	phosphoglycolate phosphatase activity
HW274_RS10675	COG0698	ribose 5-phosphate isomerase
HW274_RS10680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW274_RS10685	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW274_RS10685	COG0596	Alpha beta hydrolase
HW274_RS10695	COG2197	response regulator
HW274_RS10700	COG4585	Histidine kinase
HW274_RS10715	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HW274_RS10725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW274_RS10725	COG0574	Belongs to the PEP-utilizing enzyme family
HW274_RS10735	COG2211	Major facilitator Superfamily
HW274_RS10745	COG0297	glycogen (starch) synthase activity
HW274_RS10745	COG0438	transferase activity, transferring glycosyl groups
HW274_RS10790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW274_RS10805	COG1490	D-aminoacyl-tRNA deacylase activity
HW274_RS10815	COG0354	folic acid binding
HW274_RS10820	COG3485	protocatechuate 3,4-dioxygenase
HW274_RS10830	COG0745	RESPONSE REGULATOR receiver
HW274_RS10835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW274_RS10855	COG0406	alpha-ribazole phosphatase activity
HW274_RS10855	COG0494	nUDIX hydrolase
HW274_RS10860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HW274_RS10880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_RS10920	COG0513	Belongs to the DEAD box helicase family
HW274_RS10935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW274_RS10945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW274_RS10960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW274_RS10975	COG0431	NADPH-dependent FMN reductase
HW274_RS10980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW274_RS11000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW274_RS11015	COG0444	Belongs to the ABC transporter superfamily
HW274_RS11020	COG0129	dihydroxy-acid dehydratase activity
HW274_RS11050	COG4585	Histidine kinase
HW274_RS11055	COG2197	response regulator
HW274_RS11060	COG0193	aminoacyl-tRNA hydrolase activity
HW274_RS11065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HW274_RS11100	COG0148	phosphopyruvate hydratase activity
HW274_RS11135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW274_RS11240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW274_RS11245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HW274_RS11245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW274_RS11255	COG0714	Associated with various cellular activities
HW274_RS11295	COG0488	(ABC) transporter
HW274_RS11300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HW274_RS11305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW274_RS11320	COG0084	hydrolase, TatD family'
HW274_RS11325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW274_RS11335	COG1335	isochorismatase
HW274_RS11355	COG0697	spore germination
HW274_RS11360	COG0583	DNA-binding transcription factor activity
HW274_RS11380	COG2197	response regulator
HW274_RS11405	COG1297	OPT oligopeptide transporter protein
HW274_RS11410	COG2814	Major facilitator Superfamily
HW274_RS11415	COG0640	Transcriptional regulator
HW274_RS11420	COG1215	transferase activity, transferring glycosyl groups
HW274_RS11450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW274_RS11460	COG1970	mechanosensitive ion channel activity
HW274_RS11485	COG0791	NLP P60 protein
HW274_RS11485	COG1388	LysM domain
HW274_RS11485	COG3103	Sh3 type 3 domain protein
HW274_RS11510	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_RS11535	COG2252	PERMEase
HW274_RS11560	COG1061	Type III restriction enzyme res subunit
HW274_RS11575	COG1842	Phage shock protein A
HW274_RS11585	COG0745	RESPONSE REGULATOR receiver
HW274_RS11590	COG2205	protein histidine kinase activity
HW274_RS11605	COG0459	protein refolding
HW274_RS11620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HW274_RS11625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HW274_RS11630	COG0215	cysteine-tRNA ligase activity
HW274_RS11635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW274_RS11665	COG3842	ATPase activity
HW274_RS11695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW274_RS11715	COG0561	phosphatase activity
HW274_RS11735	COG3716	PTS system mannose fructose sorbose family IID component
HW274_RS11740	COG3715	PTS system
HW274_RS11745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_RS11745	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW274_RS11750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW274_RS11770	COG1609	Transcriptional regulator
HW274_RS11775	COG0546	phosphoglycolate phosphatase activity
HW274_RS11790	COG0542	response to heat
HW274_RS11815	COG0577	efflux transmembrane transporter activity
HW274_RS11835	COG0745	RESPONSE REGULATOR receiver
HW274_RS11840	COG2205	protein histidine kinase activity
HW274_RS11860	COG2311	Membrane
HW274_RS11865	COG0789	Transcriptional regulator
HW274_RS11870	COG0484	heat shock protein binding
HW274_RS11875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW274_RS11880	COG0443	Heat shock 70 kDa protein
HW274_RS11890	COG2814	Major facilitator Superfamily
HW274_RS11895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_RS11905	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HW274_RS11910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS11925	COG1131	(ABC) transporter
HW274_RS11945	COG2197	response regulator
HW274_RS11950	COG4585	Histidine kinase
HW274_RS11990	COG0778	Nitroreductase
HW274_RS11995	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HW274_RS12085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW274_RS12180	COG0601	transmembrane transport
HW274_RS12185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW274_RS12190	COG3842	ATPase activity
HW274_RS12210	COG1733	regulation of RNA biosynthetic process
HW274_RS12235	COG2181	nitrate reductase activity
HW274_RS12235	COG0247	lactate metabolic process
HW274_RS12240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW274_RS12250	COG2197	response regulator
HW274_RS12255	COG4585	Histidine kinase
HW274_RS12300	COG1132	(ABC) transporter
HW274_RS12340	COG2197	response regulator
HW274_RS12355	COG2755	lipolytic protein G-D-S-L family
HW274_RS12370	COG0483	inositol monophosphate 1-phosphatase activity
HW274_RS12375	COG1113	amino acid transport
HW274_RS12385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW274_RS12390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW274_RS12395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW274_RS12395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW274_RS12400	COG1940	carbohydrate kinase activity
HW274_RS12405	COG4607	ABC-type enterochelin transport system periplasmic component
HW274_RS12410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS12415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_RS12420	COG1120	ATPase activity
HW274_RS12430	COG0628	permease
HW274_RS12440	COG1854	S-ribosylhomocysteine lyase activity
HW274_RS12450	COG2409	Drug exporters of the RND superfamily
HW274_RS12470	COG0789	Transcriptional regulator
HW274_RS12475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW274_RS12480	COG0569	domain protein
HW274_RS12480	COG2985	domain, Protein
HW274_RS12485	COG1966	Carbon starvation protein
HW274_RS12505	COG1716	ATPase activity
HW274_RS12510	COG1716	ATPase activity
HW274_RS12525	COG0768	penicillin binding
HW274_RS12530	COG0515	serine threonine protein kinase
HW274_RS12535	COG0515	serine threonine protein kinase
HW274_RS12535	COG2815	serine threonine protein kinase
HW274_RS12540	COG2197	response regulator
HW274_RS12545	COG4585	Histidine kinase
HW274_RS12555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW274_RS12560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HW274_RS12570	COG3345	alpha-galactosidase
HW274_RS12575	COG0673	inositol 2-dehydrogenase activity
HW274_RS12580	COG0617	tRNA 3'-terminal CCA addition
HW274_RS12595	COG0728	peptidoglycan biosynthetic process
HW274_RS12600	COG0492	ferredoxin-NADP+ reductase activity
HW274_RS12605	COG3118	belongs to the thioredoxin family
HW274_RS12615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW274_RS12620	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW274_RS12635	COG0357	Ribosomal RNA small subunit methyltransferase G
HW274_RS12645	COG0706	membrane insertase activity
HW274_RS12650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HW274_RS12655	COG0594	ribonuclease P activity
HW274_RS12660	COG0230	Belongs to the bacterial ribosomal protein bL34 family