locus-tag	class	description
FBF36_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FBF36_RS00010	COG0592	DNA-directed DNA polymerase activity
FBF36_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FBF36_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FBF36_RS00025	COG0187	DNA topoisomerase II activity
FBF36_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FBF36_RS00065	COG1476	TRANSCRIPTIONal
FBF36_RS00120	COG3764	Sortase (surface protein transpeptidase)
FBF36_RS00130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FBF36_RS00135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FBF36_RS00140	COG0360	Binds together with S18 to 16S ribosomal RNA
FBF36_RS00150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FBF36_RS00155	COG0359	binds to the 23S rRNA
FBF36_RS00160	COG0534	Mate efflux family protein
FBF36_RS00165	COG0305	Participates in initiation and elongation during chromosome replication
FBF36_RS00175	COG0351	phosphomethylpyrimidine kinase
FBF36_RS00190	COG1733	regulation of RNA biosynthetic process
FBF36_RS00250	COG1780	Probably involved in ribonucleotide reductase function
FBF36_RS00255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FBF36_RS00285	COG1131	(ABC) transporter
FBF36_RS00295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FBF36_RS00315	COG1609	Transcriptional regulator
FBF36_RS00325	COG2211	Major facilitator Superfamily
FBF36_RS00330	COG0672	)-iron permease
FBF36_RS00335	COG2822	iron ion transport
FBF36_RS00340	COG2837	iron assimilation
FBF36_RS00350	COG1309	transcriptional regulator
FBF36_RS00360	COG1597	lipid kinase activity
FBF36_RS00370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FBF36_RS00380	COG1653	transport
FBF36_RS00425	COG0626	cystathionine gamma-synthase activity
FBF36_RS00430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FBF36_RS00450	COG1937	Protein conserved in bacteria
FBF36_RS00460	COG2197	response regulator
FBF36_RS00515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FBF36_RS00580	COG1950	PFAM Membrane protein of
FBF36_RS00585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FBF36_RS00650	COG3739	integral membrane protein
FBF36_RS00675	COG0463	Glycosyl transferase, family 2
FBF36_RS00710	COG2011	ABC-type metal ion transport system permease component
FBF36_RS00715	COG1464	Belongs to the NlpA lipoprotein family
FBF36_RS00720	COG0577	efflux transmembrane transporter activity
FBF36_RS00720	COG1136	(ABC) transporter
FBF36_RS00730	COG3311	Transcriptional regulator
FBF36_RS00735	COG4585	Histidine kinase
FBF36_RS00745	COG1929	Belongs to the glycerate kinase type-1 family
FBF36_RS00760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FBF36_RS00770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FBF36_RS00775	COG0037	tRNA processing
FBF36_RS00775	COG0590	tRNA wobble adenosine to inosine editing
FBF36_RS00785	COG1643	Atp-dependent helicase
FBF36_RS00825	COG0702	epimerase
FBF36_RS00855	COG2233	PERMEase
FBF36_RS00925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FBF36_RS00960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FBF36_RS00990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FBF36_RS01000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FBF36_RS01005	COG0113	porphobilinogen synthase activity
FBF36_RS01015	COG0181	hydroxymethylbilane synthase activity
FBF36_RS01025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FBF36_RS01030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FBF36_RS01040	COG3253	May function as heme-dependent peroxidase
FBF36_RS01040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FBF36_RS01095	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FBF36_RS01220	COG0783	Belongs to the Dps family
FBF36_RS01260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FBF36_RS01260	COG1918	ferrous iron import across plasma membrane
FBF36_RS01275	COG1918	ferrous iron import across plasma membrane
FBF36_RS01275	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FBF36_RS01295	COG1597	lipid kinase activity
FBF36_RS01315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FBF36_RS01320	COG0714	Associated with various cellular activities
FBF36_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
FBF36_RS01340	COG1408	metallophosphoesterase
FBF36_RS01370	COG1136	(ABC) transporter
FBF36_RS01380	COG2267	carboxylic ester hydrolase activity
FBF36_RS01390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FBF36_RS01440	COG0450	alkyl hydroperoxide reductase
FBF36_RS01445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FBF36_RS01475	COG2205	protein histidine kinase activity
FBF36_RS01480	COG0745	RESPONSE REGULATOR receiver
FBF36_RS01495	COG1754	DNA topoisomerase type I activity
FBF36_RS01495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FBF36_RS01505	COG0745	RESPONSE REGULATOR receiver
FBF36_RS01510	COG0642	Histidine kinase
FBF36_RS01540	COG2188	Transcriptional regulator
FBF36_RS01560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FBF36_RS01565	COG0470	DNA polymerase III
FBF36_RS01575	COG0596	Alpha beta hydrolase
FBF36_RS01590	COG0252	asparaginase activity
FBF36_RS01595	COG1113	amino acid transport
FBF36_RS01620	COG5002	protein histidine kinase activity
FBF36_RS01635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FBF36_RS01665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FBF36_RS01675	COG1643	Atp-dependent helicase
FBF36_RS01695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FBF36_RS01700	COG2860	membrane
FBF36_RS01720	COG5650	phosphatidylinositol metabolic process
FBF36_RS01755	COG0714	Associated with various cellular activities
FBF36_RS01815	COG0717	Belongs to the dCTP deaminase family
FBF36_RS01825	COG2176	DNA-directed DNA polymerase activity
FBF36_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
FBF36_RS01855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FBF36_RS01860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FBF36_RS01880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FBF36_RS01885	COG0191	fructose-bisphosphate aldolase activity
FBF36_RS01915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FBF36_RS01950	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FBF36_RS01995	COG0151	Belongs to the GarS family
FBF36_RS02000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FBF36_RS02020	COG0047	phosphoribosylformylglycinamidine synthase activity
FBF36_RS02055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FBF36_RS02085	COG1090	epimerase
FBF36_RS02095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FBF36_RS02100	COG0737	Belongs to the 5'-nucleotidase family
FBF36_RS02105	COG0737	Belongs to the 5'-nucleotidase family
FBF36_RS02110	COG4085	toxin activity
FBF36_RS02110	COG1525	nuclease
FBF36_RS02110	COG0737	Belongs to the 5'-nucleotidase family
FBF36_RS02115	COG1349	DNA-binding transcription factor activity
FBF36_RS02125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FBF36_RS02125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FBF36_RS02125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FBF36_RS02135	COG0557	exoribonuclease II activity
FBF36_RS02155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FBF36_RS02165	COG3973	AAA domain
FBF36_RS02170	COG1201	RNA secondary structure unwinding
FBF36_RS02235	COG1132	(ABC) transporter
FBF36_RS02240	COG1132	(ABC) transporter
FBF36_RS02245	COG0577	efflux transmembrane transporter activity
FBF36_RS02250	COG1136	(ABC) transporter
FBF36_RS02260	COG1472	Belongs to the glycosyl hydrolase 3 family
FBF36_RS02285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FBF36_RS02300	COG0668	transmembrane transport
FBF36_RS02305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FBF36_RS02325	COG1722	exodeoxyribonuclease VII activity
FBF36_RS02330	COG0640	Transcriptional regulator
FBF36_RS02340	COG1570	exodeoxyribonuclease VII activity
FBF36_RS02345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FBF36_RS02350	COG0833	amino acid
FBF36_RS02365	COG1595	DNA-templated transcription, initiation
FBF36_RS02385	COG1302	Protein conserved in bacteria
FBF36_RS02395	COG1322	Protein conserved in bacteria
FBF36_RS02405	COG0012	GTP binding
FBF36_RS02445	COG1733	regulation of RNA biosynthetic process
FBF36_RS02470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FBF36_RS02475	COG2873	o-acetylhomoserine
FBF36_RS02485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FBF36_RS02490	COG2027	D-alanyl-D-alanine carboxypeptidase
FBF36_RS02500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FBF36_RS02510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FBF36_RS02515	COG0302	gtp cyclohydrolase
FBF36_RS02550	COG2197	response regulator
FBF36_RS02620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FBF36_RS02625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FBF36_RS02650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FBF36_RS02655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FBF36_RS02665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FBF36_RS02700	COG3599	regulation of cell shape
FBF36_RS02710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS02715	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS02720	COG1120	ATPase activity
FBF36_RS02725	COG4592	Periplasmic binding protein
FBF36_RS02735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FBF36_RS02765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FBF36_RS02790	COG1556	Lactate utilization protein
FBF36_RS02795	COG1139	Iron-sulfur cluster binding protein
FBF36_RS02800	COG0247	lactate metabolic process
FBF36_RS02820	COG1620	l-lactate permease
FBF36_RS02830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FBF36_RS02835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FBF36_RS02840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FBF36_RS02845	COG2390	Transcriptional regulator
FBF36_RS02850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FBF36_RS02875	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FBF36_RS02900	COG2390	Transcriptional regulator
FBF36_RS02910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FBF36_RS02925	COG0477	Major facilitator Superfamily
FBF36_RS02955	COG2376	Dihydroxyacetone kinase
FBF36_RS02960	COG1461	Dihydroxyacetone kinase
FBF36_RS02985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FBF36_RS03000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FBF36_RS03005	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FBF36_RS03015	COG0436	Aminotransferase
FBF36_RS03025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FBF36_RS03030	COG0250	Participates in transcription elongation, termination and antitermination
FBF36_RS03035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FBF36_RS03040	COG0081	regulation of translation
FBF36_RS03055	COG2885	chlorophyll binding
FBF36_RS03070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FBF36_RS03075	COG0049	tRNA binding
FBF36_RS03080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FBF36_RS03085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FBF36_RS03100	COG0051	transcription antitermination factor activity, RNA binding
FBF36_RS03105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FBF36_RS03115	COG0089	rRNA binding
FBF36_RS03120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FBF36_RS03125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FBF36_RS03130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FBF36_RS03135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FBF36_RS03140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FBF36_RS03145	COG0255	Belongs to the universal ribosomal protein uL29 family
FBF36_RS03150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FBF36_RS03155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FBF36_RS03160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FBF36_RS03165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FBF36_RS03170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FBF36_RS03175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FBF36_RS03180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FBF36_RS03185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FBF36_RS03190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FBF36_RS03195	COG1841	ribosomal large subunit assembly
FBF36_RS03210	COG0563	adenylate kinase activity
FBF36_RS03215	COG0024	Methionine aminopeptidase
FBF36_RS03220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FBF36_RS03225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FBF36_RS03230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FBF36_RS03235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FBF36_RS03240	COG0202	RNA polymerase activity
FBF36_RS03260	COG1285	pathogenesis
FBF36_RS03270	COG0101	tRNA pseudouridine synthase activity
FBF36_RS03275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FBF36_RS03280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FBF36_RS03315	COG2132	Multicopper oxidase
FBF36_RS03320	COG2205	protein histidine kinase activity
FBF36_RS03325	COG0745	RESPONSE REGULATOR receiver
FBF36_RS03355	COG1396	sequence-specific DNA binding
FBF36_RS03365	COG1072	(Pantothenic acid kinase))
FBF36_RS03375	COG0736	holo-[acyl-carrier-protein] synthase activity
FBF36_RS03385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FBF36_RS03390	COG0802	atpase or kinase
FBF36_RS03415	COG1053	succinate dehydrogenase
FBF36_RS03420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FBF36_RS03425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FBF36_RS03430	COG2818	Glycosylase
FBF36_RS03435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FBF36_RS03445	COG2375	cellular response to nickel ion
FBF36_RS03445	COG1132	(ABC) transporter
FBF36_RS03450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FBF36_RS03460	COG2949	membrane
FBF36_RS03465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FBF36_RS03485	COG0516	GMP reductase activity
FBF36_RS03490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FBF36_RS03495	COG4975	Glucose uptake
FBF36_RS03510	COG0328	RNA-DNA hybrid ribonuclease activity
FBF36_RS03520	COG2197	response regulator
FBF36_RS03525	COG4585	Histidine kinase
FBF36_RS03540	COG1131	(ABC) transporter
FBF36_RS03545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FBF36_RS03570	COG1082	Xylose isomerase domain protein TIM barrel
FBF36_RS03580	COG1609	Transcriptional regulator
FBF36_RS03585	COG1082	Xylose isomerase domain protein TIM barrel
FBF36_RS03590	COG2814	Major facilitator Superfamily
FBF36_RS03595	COG0673	inositol 2-dehydrogenase activity
FBF36_RS03600	COG1609	Transcriptional regulator
FBF36_RS03605	COG2017	converts alpha-aldose to the beta-anomer
FBF36_RS03610	COG0673	inositol 2-dehydrogenase activity
FBF36_RS03615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FBF36_RS03620	COG2188	Transcriptional regulator
FBF36_RS03635	COG3718	enzyme involved in inositol metabolism
FBF36_RS03640	COG3962	Belongs to the TPP enzyme family
FBF36_RS03655	COG0673	inositol 2-dehydrogenase activity
FBF36_RS03660	COG1082	Xylose isomerase domain protein TIM barrel
FBF36_RS03665	COG2814	Major facilitator Superfamily
FBF36_RS03685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FBF36_RS03685	COG0519	Catalyzes the synthesis of GMP from XMP
FBF36_RS03710	COG1131	(ABC) transporter
FBF36_RS03715	COG4585	Histidine kinase
FBF36_RS03745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FBF36_RS03795	COG3321	synthase
FBF36_RS03795	COG0604	alcohol dehydrogenase
FBF36_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
FBF36_RS03800	COG2267	carboxylic ester hydrolase activity
FBF36_RS03805	COG2267	carboxylic ester hydrolase activity
FBF36_RS03815	COG3654	unkown
FBF36_RS03845	COG2205	protein histidine kinase activity
FBF36_RS03850	COG2197	response regulator
FBF36_RS03860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FBF36_RS03870	COG0356	it plays a direct role in the translocation of protons across the membrane
FBF36_RS03880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FBF36_RS03885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FBF36_RS03890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FBF36_RS03895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FBF36_RS03900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FBF36_RS03905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FBF36_RS03915	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FBF36_RS03945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FBF36_RS03950	COG0254	rRNA binding
FBF36_RS03955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FBF36_RS03960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FBF36_RS03965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FBF36_RS03975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FBF36_RS03980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FBF36_RS03985	COG1621	beta-fructofuranosidase activity
FBF36_RS04005	COG1254	Belongs to the acylphosphatase family
FBF36_RS04015	COG1136	(ABC) transporter
FBF36_RS04015	COG0577	efflux transmembrane transporter activity
FBF36_RS04020	COG0577	efflux transmembrane transporter activity
FBF36_RS04020	COG1136	(ABC) transporter
FBF36_RS04030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FBF36_RS04035	COG1349	DNA-binding transcription factor activity
FBF36_RS04060	COG1744	ABC transporter substrate-binding protein PnrA-like
FBF36_RS04065	COG3845	ABC transporter
FBF36_RS04070	COG4603	Belongs to the binding-protein-dependent transport system permease family
FBF36_RS04075	COG1079	Belongs to the binding-protein-dependent transport system permease family
FBF36_RS04105	COG0803	Belongs to the bacterial solute-binding protein 9 family
FBF36_RS04110	COG1121	(ABC) transporter
FBF36_RS04135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FBF36_RS04140	COG1611	Belongs to the LOG family
FBF36_RS04155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FBF36_RS04170	COG2239	Acts as a magnesium transporter
FBF36_RS04180	COG1082	Xylose isomerase domain protein TIM barrel
FBF36_RS04195	COG0006	proline dipeptidase activity
FBF36_RS04200	COG0673	inositol 2-dehydrogenase activity
FBF36_RS04210	COG2095	MarC family integral membrane protein
FBF36_RS04215	COG0513	Belongs to the DEAD box helicase family
FBF36_RS04260	COG0114	fumarate hydratase activity
FBF36_RS04280	COG0346	lactoylglutathione lyase activity
FBF36_RS04290	COG1174	glycine betaine transport
FBF36_RS04310	COG1733	regulation of RNA biosynthetic process
FBF36_RS04320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FBF36_RS04350	COG1674	ftsk spoiiie
FBF36_RS04355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FBF36_RS04365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF36_RS04370	COG0154	amidase activity
FBF36_RS04375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF36_RS04405	COG2966	Psort location CytoplasmicMembrane, score
FBF36_RS04410	COG0569	domain protein
FBF36_RS04410	COG2985	domain, Protein
FBF36_RS04425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FBF36_RS04430	COG2814	Major facilitator Superfamily
FBF36_RS04440	COG0473	3-isopropylmalate dehydrogenase activity
FBF36_RS04445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FBF36_RS04450	COG1316	TRANSCRIPTIONal
FBF36_RS04455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FBF36_RS04460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FBF36_RS04465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FBF36_RS04485	COG1216	Glycosyl transferase, family 2
FBF36_RS04495	COG1134	teichoic acid transport
FBF36_RS04515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FBF36_RS04525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FBF36_RS04540	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FBF36_RS04545	COG0515	serine threonine protein kinase
FBF36_RS04550	COG1716	ATPase activity
FBF36_RS04550	COG1131	(ABC) transporter
FBF36_RS04550	COG0842	Transport permease protein
FBF36_RS04560	COG1162	GTPase activity
FBF36_RS04565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FBF36_RS04580	COG2884	Cell division ATP-binding protein ftsE
FBF36_RS04625	COG2188	Transcriptional regulator
FBF36_RS04630	COG0747	negative chemotaxis
FBF36_RS04640	COG0444	Belongs to the ABC transporter superfamily
FBF36_RS04645	COG4608	Belongs to the ABC transporter superfamily
FBF36_RS04660	COG1175	transmembrane transport
FBF36_RS04670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FBF36_RS04675	COG1940	carbohydrate kinase activity
FBF36_RS04680	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FBF36_RS04700	COG0363	glucosamine-6-phosphate deaminase activity
FBF36_RS04720	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FBF36_RS04730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FBF36_RS04745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FBF36_RS04750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FBF36_RS04795	COG3304	Inner membrane component domain
FBF36_RS04800	COG0833	amino acid
FBF36_RS04805	COG2040	homocysteine
FBF36_RS04815	COG1115	amino acid carrier protein
FBF36_RS04820	COG1115	amino acid carrier protein
FBF36_RS04825	COG1115	amino acid carrier protein
FBF36_RS04830	COG1115	amino acid carrier protein
FBF36_RS04835	COG0179	Fumarylacetoacetate (FAA) hydrolase
FBF36_RS04845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FBF36_RS04880	COG0726	polysaccharide deacetylase
FBF36_RS04885	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FBF36_RS04890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FBF36_RS04895	COG1674	ftsk spoiiie
FBF36_RS04900	COG2843	Capsule synthesis protein
FBF36_RS04910	COG1546	Belongs to the CinA family
FBF36_RS04910	COG1058	Belongs to the CinA family
FBF36_RS04915	COG1396	sequence-specific DNA binding
FBF36_RS04925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FBF36_RS04930	COG2137	regulation of response to DNA damage stimulus
FBF36_RS04935	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FBF36_RS04940	COG1252	NADH dehydrogenase
FBF36_RS04945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FBF36_RS04970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FBF36_RS04975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FBF36_RS04980	COG1114	Component of the transport system for branched-chain amino acids
FBF36_RS04990	COG2813	Specifically methylates the guanine in position
FBF36_RS05005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FBF36_RS05020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FBF36_RS05030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FBF36_RS05050	COG0066	3-isopropylmalate dehydratase activity
FBF36_RS05055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FBF36_RS05065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FBF36_RS05070	COG1181	Belongs to the D-alanine--D-alanine ligase family
FBF36_RS05080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FBF36_RS05085	COG1461	Dihydroxyacetone kinase
FBF36_RS05100	COG0235	Class ii aldolase
FBF36_RS05110	COG4806	L-rhamnose isomerase
FBF36_RS05110	COG1070	Carbohydrate kinase
FBF36_RS05115	COG4154	Belongs to the RbsD FucU family
FBF36_RS05120	COG0738	Major facilitator superfamily
FBF36_RS05135	COG0395	ABC-type sugar transport system, permease component
FBF36_RS05140	COG1175	transmembrane transport
FBF36_RS05150	COG1609	Transcriptional regulator
FBF36_RS05155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FBF36_RS05170	COG0571	ribonuclease III activity
FBF36_RS05175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FBF36_RS05190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FBF36_RS05195	COG4988	ABC transporter
FBF36_RS05200	COG1294	oxidase, subunit
FBF36_RS05205	COG1271	oxidase subunit
FBF36_RS05210	COG1530	ribonuclease E activity
FBF36_RS05215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FBF36_RS05220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FBF36_RS05225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FBF36_RS05230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FBF36_RS05235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FBF36_RS05240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FBF36_RS05255	COG5002	protein histidine kinase activity
FBF36_RS05260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FBF36_RS05275	COG1132	(ABC) transporter
FBF36_RS05280	COG0297	glycogen (starch) synthase activity
FBF36_RS05290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FBF36_RS05295	COG1349	DNA-binding transcription factor activity
FBF36_RS05305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FBF36_RS05315	COG0799	negative regulation of ribosome biogenesis
FBF36_RS05320	COG0406	alpha-ribazole phosphatase activity
FBF36_RS05335	COG2095	MarC family integral membrane protein
FBF36_RS05350	COG0813	purine-nucleoside phosphorylase activity
FBF36_RS05355	COG0733	neurotransmitter:sodium symporter activity
FBF36_RS05385	COG0537	adenosine 5'-monophosphoramidase activity
FBF36_RS05400	COG0789	Transcriptional regulator
FBF36_RS05405	COG0495	leucyl-tRNA aminoacylation
FBF36_RS05420	COG0433	COG0433 Predicted ATPase
FBF36_RS05425	COG0438	transferase activity, transferring glycosyl groups
FBF36_RS05430	COG1307	EDD domain protein, DegV family
FBF36_RS05455	COG4868	Belongs to the UPF0371 family
FBF36_RS05460	COG0268	Binds directly to 16S ribosomal RNA
FBF36_RS05475	COG0159	tryptophan synthase activity
FBF36_RS05485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FBF36_RS05490	COG0512	Glutamine amidotransferase of anthranilate synthase
FBF36_RS05495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FBF36_RS05505	COG0481	GTPase activity
FBF36_RS05515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FBF36_RS05520	COG2807	transmembrane transport
FBF36_RS05540	COG1673	EVE domain
FBF36_RS05580	COG1420	regulation of RNA biosynthetic process
FBF36_RS05585	COG0484	heat shock protein binding
FBF36_RS05590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FBF36_RS05605	COG1309	transcriptional regulator
FBF36_RS05645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FBF36_RS05655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FBF36_RS05665	COG1476	TRANSCRIPTIONal
FBF36_RS05675	COG1131	(ABC) transporter
FBF36_RS05680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FBF36_RS05690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FBF36_RS05710	COG1116	anion transmembrane transporter activity
FBF36_RS05750	COG1476	TRANSCRIPTIONal
FBF36_RS05765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FBF36_RS05770	COG1381	Involved in DNA repair and RecF pathway recombination
FBF36_RS05775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FBF36_RS05785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FBF36_RS05800	COG0423	glycine-tRNA ligase activity
FBF36_RS05825	COG0560	Phosphoserine phosphatase
FBF36_RS05835	COG0297	glycogen (starch) synthase activity
FBF36_RS05845	COG1119	ATPase activity
FBF36_RS05875	COG0488	(ABC) transporter
FBF36_RS05885	COG0545	Peptidyl-prolyl cis-trans isomerase
FBF36_RS05915	COG0205	6-phosphofructokinase activity
FBF36_RS05925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FBF36_RS05930	COG2815	serine threonine protein kinase
FBF36_RS05930	COG0515	serine threonine protein kinase
FBF36_RS05935	COG0142	geranyltranstransferase activity
FBF36_RS05940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FBF36_RS05960	COG0187	DNA topoisomerase II activity
FBF36_RS05965	COG0454	-acetyltransferase
FBF36_RS05965	COG0456	acetyltransferase
FBF36_RS05975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FBF36_RS06020	COG0569	domain protein
FBF36_RS06025	COG0531	amino acid
FBF36_RS06030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FBF36_RS06040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FBF36_RS06050	COG2161	toxin-antitoxin pair type II binding
FBF36_RS06060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FBF36_RS06075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FBF36_RS06080	COG4221	oxidoreductase activity
FBF36_RS06085	COG1881	PFAM PEBP family protein
FBF36_RS06100	COG0671	phosphoesterase, PA-phosphatase related
FBF36_RS06105	COG1435	thymidine kinase activity
FBF36_RS06125	COG0587	DNA-directed DNA polymerase activity
FBF36_RS06145	COG3152	Membrane
FBF36_RS06170	COG0477	Major facilitator Superfamily
FBF36_RS06180	COG0028	Belongs to the TPP enzyme family
FBF36_RS06185	COG0339	signal peptide processing
FBF36_RS06190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FBF36_RS06200	COG0667	Aldo Keto reductase
FBF36_RS06205	COG0425	Belongs to the sulfur carrier protein TusA family
FBF36_RS06210	COG2391	methyltransferase activity
FBF36_RS06220	COG1994	Peptidase M50
FBF36_RS06220	COG0517	IMP dehydrogenase activity
FBF36_RS06230	COG1222	aaa ATPase
FBF36_RS06245	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FBF36_RS06255	COG0107	imidazoleglycerol-phosphate synthase activity
FBF36_RS06280	COG0134	indole-3-glycerol-phosphate synthase activity
FBF36_RS06320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FBF36_RS06340	COG2815	serine threonine protein kinase
FBF36_RS06340	COG0515	serine threonine protein kinase
FBF36_RS06355	COG0494	nUDIX hydrolase
FBF36_RS06405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FBF36_RS06420	COG2050	protein possibly involved in aromatic compounds catabolism
FBF36_RS06430	COG0539	negative regulation of cytoplasmic translation
FBF36_RS06440	COG0237	dephospho-CoA kinase activity
FBF36_RS06450	COG0556	nucleotide-excision repair
FBF36_RS06475	COG0500	methyltransferase
FBF36_RS06520	COG0322	excinuclease ABC activity
FBF36_RS06525	COG3585	molybdate ion transport
FBF36_RS06535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FBF36_RS06540	COG1660	Displays ATPase and GTPase activities
FBF36_RS06550	COG1481	regulation of sporulation
FBF36_RS06555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FBF36_RS06560	COG0126	phosphoglycerate kinase activity
FBF36_RS06565	COG0149	triose-phosphate isomerase activity
FBF36_RS06570	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FBF36_RS06590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FBF36_RS06605	COG1160	GTP binding
FBF36_RS06620	COG0166	Belongs to the GPI family
FBF36_RS06625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FBF36_RS06655	COG0363	glucosamine-6-phosphate deaminase activity
FBF36_RS06670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FBF36_RS06680	COG1716	ATPase activity
FBF36_RS06700	COG0667	Aldo Keto reductase
FBF36_RS06705	COG0443	Heat shock 70 kDa protein
FBF36_RS06720	COG1621	beta-fructofuranosidase activity
FBF36_RS06725	COG1263	PTS System
FBF36_RS06725	COG2190	(PTS) system
FBF36_RS06725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FBF36_RS06730	COG1609	Transcriptional regulator
FBF36_RS06740	COG1136	(ABC) transporter
FBF36_RS06745	COG0577	efflux transmembrane transporter activity
FBF36_RS06750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FBF36_RS06755	COG1247	-acetyltransferase
FBF36_RS06760	COG0205	6-phosphofructokinase activity
FBF36_RS06770	COG1216	Glycosyl transferase, family 2
FBF36_RS06775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FBF36_RS06780	COG2354	Protein conserved in bacteria
FBF36_RS06795	COG0805	protein transport
FBF36_RS06800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FBF36_RS06820	COG4585	Histidine kinase
FBF36_RS06825	COG2197	response regulator
FBF36_RS06830	COG1131	(ABC) transporter
FBF36_RS06840	COG0140	phosphoribosyl-ATP diphosphatase activity
FBF36_RS06845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FBF36_RS06850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FBF36_RS06855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FBF36_RS06860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FBF36_RS06865	COG0736	holo-[acyl-carrier-protein] synthase activity
FBF36_RS06885	COG0179	Fumarylacetoacetate (FAA) hydrolase
FBF36_RS06890	COG1012	belongs to the aldehyde dehydrogenase family
FBF36_RS06900	COG0477	Major facilitator Superfamily
FBF36_RS06915	COG3971	2-oxopent-4-enoate hydratase activity
FBF36_RS06930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FBF36_RS06935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FBF36_RS06940	COG4770	biotin carboxylase activity
FBF36_RS06945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FBF36_RS06955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FBF36_RS06970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FBF36_RS06975	COG0549	Belongs to the carbamate kinase family
FBF36_RS06990	COG0477	Major facilitator Superfamily
FBF36_RS07005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FBF36_RS07015	COG1758	RNA polymerase activity
FBF36_RS07020	COG0194	GDP metabolic process
FBF36_RS07030	COG0284	orotidine-5'-phosphate decarboxylase activity
FBF36_RS07035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FBF36_RS07045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FBF36_RS07050	COG0540	Belongs to the ATCase OTCase family
FBF36_RS07055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FBF36_RS07070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FBF36_RS07075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FBF36_RS07080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FBF36_RS07090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FBF36_RS07095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FBF36_RS07105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FBF36_RS07110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FBF36_RS07115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FBF36_RS07130	COG0009	L-threonylcarbamoyladenylate synthase
FBF36_RS07155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FBF36_RS07185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FBF36_RS07185	COG1116	anion transmembrane transporter activity
FBF36_RS07205	COG0124	histidyl-tRNA synthetase
FBF36_RS07215	COG0488	(ABC) transporter
FBF36_RS07220	COG1196	nuclear chromosome segregation
FBF36_RS07225	COG0789	Transcriptional regulator
FBF36_RS07245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FBF36_RS07250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FBF36_RS07255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FBF36_RS07260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FBF36_RS07270	COG2255	four-way junction helicase activity
FBF36_RS07275	COG0632	four-way junction helicase activity
FBF36_RS07280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FBF36_RS07285	COG0217	transcriptional regulatory protein
FBF36_RS07290	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FBF36_RS07295	COG1051	belongs to the nudix hydrolase family
FBF36_RS07300	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FBF36_RS07315	COG0438	transferase activity, transferring glycosyl groups
FBF36_RS07335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FBF36_RS07400	COG1882	Formate acetyltransferase
FBF36_RS07410	COG1073	alpha beta
FBF36_RS07415	COG0038	chloride channel
FBF36_RS07425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FBF36_RS07430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FBF36_RS07435	COG0508	dehydrogenase complex catalyzes the overall conversion of
FBF36_RS07455	COG0321	lipoyl(octanoyl) transferase activity
FBF36_RS07460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FBF36_RS07480	COG0765	amino acid transport
FBF36_RS07495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FBF36_RS07500	COG0174	glutamine synthetase
FBF36_RS07505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FBF36_RS07525	COG3022	response to hydroperoxide
FBF36_RS07535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FBF36_RS07550	COG0436	Aminotransferase
FBF36_RS07580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FBF36_RS07590	COG1027	Aspartate ammonia-lyase
FBF36_RS07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FBF36_RS07630	COG0358	DNA primase activity
FBF36_RS07645	COG1609	Transcriptional regulator
FBF36_RS07665	COG0167	dihydroorotate dehydrogenase activity
FBF36_RS07685	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FBF36_RS07700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FBF36_RS07715	COG3189	MarR family transcriptional regulator
FBF36_RS07725	COG2151	metal-sulfur cluster biosynthetic enzyme
FBF36_RS07730	COG0822	iron-sulfur transferase activity
FBF36_RS07740	COG0396	ATPase activity
FBF36_RS07760	COG0494	nUDIX hydrolase
FBF36_RS07790	COG0497	DNA recombination
FBF36_RS07795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FBF36_RS07810	COG0647	UMP catabolic process
FBF36_RS07835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FBF36_RS07855	COG2094	Belongs to the DNA glycosylase MPG family
FBF36_RS07860	COG0165	Argininosuccinate lyase
FBF36_RS07870	COG0137	argininosuccinate synthase activity
FBF36_RS07875	COG1438	arginine binding
FBF36_RS07880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FBF36_RS07885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FBF36_RS07895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FBF36_RS07910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FBF36_RS07920	COG1131	(ABC) transporter
FBF36_RS07950	COG0765	amino acid transport
FBF36_RS07955	COG0765	amino acid transport
FBF36_RS07960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FBF36_RS07965	COG1126	abc transporter atp-binding protein
FBF36_RS07980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FBF36_RS07985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FBF36_RS07990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FBF36_RS07995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FBF36_RS08005	COG1131	(ABC) transporter
FBF36_RS08025	COG0575	Belongs to the CDS family
FBF36_RS08035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FBF36_RS08040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FBF36_RS08055	COG0131	Imidazoleglycerol-phosphate dehydratase
FBF36_RS08060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FBF36_RS08065	COG0025	NhaP-type Na H and K H
FBF36_RS08070	COG0514	ATP-dependent DNA helicase (RecQ)
FBF36_RS08085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FBF36_RS08095	COG1215	transferase activity, transferring glycosyl groups
FBF36_RS08105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FBF36_RS08110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FBF36_RS08130	COG2501	S4 domain
FBF36_RS08135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FBF36_RS08140	COG0587	DNA-directed DNA polymerase activity
FBF36_RS08145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FBF36_RS08160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FBF36_RS08165	COG3599	regulation of cell shape
FBF36_RS08175	COG1799	cell septum assembly
FBF36_RS08180	COG1496	oxidoreductase activity
FBF36_RS08185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FBF36_RS08195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FBF36_RS08210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FBF36_RS08215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FBF36_RS08220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FBF36_RS08225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FBF36_RS08230	COG0768	penicillin binding
FBF36_RS08240	COG0275	rRNA processing
FBF36_RS08245	COG2001	Belongs to the MraZ family
FBF36_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
FBF36_RS08280	COG0318	PFAM AMP-dependent synthetase and ligase
FBF36_RS08300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FBF36_RS08310	COG1881	PFAM PEBP family protein
FBF36_RS08320	COG0300	oxidoreductase activity
FBF36_RS08325	COG0612	Peptidase, M16
FBF36_RS08330	COG1185	polyribonucleotide nucleotidyltransferase activity
FBF36_RS08335	COG1454	alcohol dehydrogenase
FBF36_RS08345	COG0196	riboflavin kinase activity
FBF36_RS08355	COG1136	(ABC) transporter
FBF36_RS08355	COG0577	efflux transmembrane transporter activity
FBF36_RS08365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FBF36_RS08370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FBF36_RS08380	COG0330	HflC and HflK could
FBF36_RS08400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FBF36_RS08410	COG0195	Participates in both transcription termination and antitermination
FBF36_RS08435	COG0442	prolyl-tRNA aminoacylation
FBF36_RS08480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FBF36_RS08485	COG0750	zinc metalloprotease
FBF36_RS08490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FBF36_RS08500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FBF36_RS08510	COG0233	cytoplasmic translational termination
FBF36_RS08520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FBF36_RS08525	COG0052	Belongs to the universal ribosomal protein uS2 family
FBF36_RS08535	COG4974	Belongs to the 'phage' integrase family
FBF36_RS08560	COG0792	nuclease activity
FBF36_RS08570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FBF36_RS08575	COG0681	Belongs to the peptidase S26 family
FBF36_RS08585	COG0681	Belongs to the peptidase S26 family
FBF36_RS08595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FBF36_RS08600	COG1837	Belongs to the UPF0109 family
FBF36_RS08620	COG1131	(ABC) transporter
FBF36_RS08630	COG1131	(ABC) transporter
FBF36_RS08640	COG4585	Histidine kinase
FBF36_RS08645	COG2197	response regulator
FBF36_RS08655	COG1131	(ABC) transporter
FBF36_RS08660	COG0842	Transport permease protein
FBF36_RS08665	COG4585	Histidine kinase
FBF36_RS08670	COG2197	response regulator
FBF36_RS08685	COG1196	nuclear chromosome segregation
FBF36_RS08690	COG4152	abc transporter atp-binding protein
FBF36_RS08700	COG0105	UTP biosynthetic process
FBF36_RS08705	COG1461	Dihydroxyacetone kinase
FBF36_RS08715	COG0285	dihydrofolate synthase activity
FBF36_RS08740	COG0656	L-ascorbic acid biosynthetic process
FBF36_RS08750	COG4221	oxidoreductase activity
FBF36_RS08755	COG2056	Na+-H+ antiporter family
FBF36_RS08760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FBF36_RS08765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FBF36_RS08770	COG0175	sulfate reduction
FBF36_RS08785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FBF36_RS08785	COG1648	precorrin-2 dehydrogenase activity
FBF36_RS08790	COG0730	response to heat
FBF36_RS08820	COG1132	(ABC) transporter
FBF36_RS08820	COG2375	cellular response to nickel ion
FBF36_RS08825	COG1122	ATPase activity
FBF36_RS08845	COG4122	O-methyltransferase activity
FBF36_RS08850	COG1222	aaa ATPase
FBF36_RS08865	COG0366	Alpha amylase catalytic
FBF36_RS08880	COG1653	transport
FBF36_RS08895	COG1605	Chorismate mutase
FBF36_RS08895	COG0287	Prephenate dehydrogenase
FBF36_RS08900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FBF36_RS08905	COG0740	serine-type endopeptidase activity
FBF36_RS08920	COG1116	anion transmembrane transporter activity
FBF36_RS08945	COG0544	peptidyl-prolyl cis-trans isomerase activity
FBF36_RS08970	COG1739	Uncharacterized protein family UPF0029
FBF36_RS08980	COG1045	serine acetyltransferase
FBF36_RS09000	COG3590	peptidase
FBF36_RS09025	COG1263	PTS System
FBF36_RS09030	COG2188	Transcriptional regulator
FBF36_RS09035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FBF36_RS09040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FBF36_RS09040	COG2190	(PTS) system
FBF36_RS09040	COG1263	PTS System
FBF36_RS09050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FBF36_RS09055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FBF36_RS09065	COG2267	carboxylic ester hydrolase activity
FBF36_RS09090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FBF36_RS09095	COG0583	DNA-binding transcription factor activity
FBF36_RS09165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FBF36_RS09185	COG1615	UPF0182 protein
FBF36_RS09200	COG3480	Lon protease (S16) C-terminal proteolytic domain
FBF36_RS09230	COG1104	cysteine desulfurase activity
FBF36_RS09240	COG2197	response regulator
FBF36_RS09275	COG3177	Filamentation induced by cAMP protein fic
FBF36_RS09280	COG0482	sulfurtransferase activity
FBF36_RS09290	COG1131	(ABC) transporter
FBF36_RS09295	COG1725	Transcriptional regulator
FBF36_RS09300	COG3831	ATPase activity
FBF36_RS09320	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FBF36_RS09330	COG0714	Associated with various cellular activities
FBF36_RS09335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FBF36_RS09340	COG2086	electron transfer activity
FBF36_RS09350	COG0180	Tryptophanyl-tRNA synthetase
FBF36_RS09355	COG0366	Alpha amylase catalytic
FBF36_RS09370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FBF36_RS09375	COG0058	SHG alpha-glucan phosphorylase activity
FBF36_RS09410	COG0395	ABC-type sugar transport system, permease component
FBF36_RS09415	COG1175	transmembrane transport
FBF36_RS09425	COG0039	L-malate dehydrogenase activity
FBF36_RS09430	COG1132	(ABC) transporter
FBF36_RS09435	COG1132	(ABC) transporter
FBF36_RS09440	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FBF36_RS09475	COG0045	succinate-CoA ligase (ADP-forming) activity
FBF36_RS09485	COG0205	6-phosphofructokinase activity
FBF36_RS09505	COG0366	Alpha amylase catalytic
FBF36_RS09510	COG1501	Belongs to the glycosyl hydrolase 31 family
FBF36_RS09515	COG0110	maltose O-acetyltransferase activity
FBF36_RS09535	COG4221	oxidoreductase activity
FBF36_RS09535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FBF36_RS09535	COG3321	synthase
FBF36_RS09535	COG0604	alcohol dehydrogenase
FBF36_RS09540	COG1846	Transcriptional regulator
FBF36_RS09555	COG2188	Transcriptional regulator
FBF36_RS09560	COG1940	carbohydrate kinase activity
FBF36_RS09565	COG2814	Major facilitator Superfamily
FBF36_RS09575	COG0657	acetylesterase activity
FBF36_RS09580	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FBF36_RS09590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FBF36_RS09595	COG0254	rRNA binding
FBF36_RS09615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FBF36_RS09620	COG0083	homoserine kinase activity
FBF36_RS09625	COG0460	homoserine dehydrogenase
FBF36_RS09635	COG0019	diaminopimelate decarboxylase activity
FBF36_RS09640	COG0018	arginyl-trna synthetase
FBF36_RS09655	COG0739	heme binding
FBF36_RS09665	COG1253	flavin adenine dinucleotide binding
FBF36_RS09670	COG0567	Dehydrogenase, E1 component
FBF36_RS09670	COG0508	dehydrogenase complex catalyzes the overall conversion of
FBF36_RS09685	COG1595	DNA-templated transcription, initiation
FBF36_RS09695	COG2838	Isocitrate dehydrogenase
FBF36_RS09710	COG1162	GTPase activity
FBF36_RS09740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FBF36_RS09750	COG0314	molybdopterin synthase activity
FBF36_RS09760	COG0315	cyclic pyranopterin monophosphate synthase activity
FBF36_RS09770	COG0521	Mo-molybdopterin cofactor biosynthetic process
FBF36_RS09770	COG0315	cyclic pyranopterin monophosphate synthase activity
FBF36_RS09785	COG1140	nitrate reductase beta subunit
FBF36_RS09810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FBF36_RS09835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS09840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS09850	COG1120	ATPase activity
FBF36_RS09860	COG2249	NAD(P)H dehydrogenase (quinone) activity
FBF36_RS09865	COG0456	acetyltransferase
FBF36_RS09870	COG2249	NAD(P)H dehydrogenase (quinone) activity
FBF36_RS09875	COG0483	inositol monophosphate 1-phosphatase activity
FBF36_RS09885	COG1968	undecaprenyl-diphosphatase activity
FBF36_RS09905	COG0420	3'-5' exonuclease activity
FBF36_RS09910	COG0419	ATPase involved in DNA repair
FBF36_RS09935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FBF36_RS09940	COG0085	RNA polymerase activity
FBF36_RS09945	COG0222	ribosome binding
FBF36_RS09950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FBF36_RS09990	COG0653	protein targeting
FBF36_RS10000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FBF36_RS10010	COG5000	phosphorelay sensor kinase activity
FBF36_RS10010	COG5002	protein histidine kinase activity
FBF36_RS10015	COG0745	RESPONSE REGULATOR receiver
FBF36_RS10035	COG0714	Associated with various cellular activities
FBF36_RS10040	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
FBF36_RS10055	COG2835	tetraacyldisaccharide 4'-kinase activity
FBF36_RS10090	COG1482	cell wall glycoprotein biosynthetic process
FBF36_RS10135	COG1215	transferase activity, transferring glycosyl groups
FBF36_RS10180	COG0463	Glycosyl transferase, family 2
FBF36_RS10195	COG1088	dTDP-glucose 4,6-dehydratase activity
FBF36_RS10210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FBF36_RS10225	COG0297	glycogen (starch) synthase activity
FBF36_RS10270	COG0463	Glycosyl transferase, family 2
FBF36_RS10290	COG1316	TRANSCRIPTIONal
FBF36_RS10325	COG0586	Pfam SNARE associated Golgi protein
FBF36_RS10330	COG5002	protein histidine kinase activity
FBF36_RS10335	COG0745	RESPONSE REGULATOR receiver
FBF36_RS10350	COG0424	maF-like protein
FBF36_RS10365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FBF36_RS10385	COG1666	GTP binding
FBF36_RS10390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS10395	COG1120	ATPase activity
FBF36_RS10405	COG2197	response regulator
FBF36_RS10425	COG0501	Belongs to the peptidase M48B family
FBF36_RS10435	COG0686	Belongs to the AlaDH PNT family
FBF36_RS10445	COG2885	chlorophyll binding
FBF36_RS10450	COG0142	geranyltranstransferase activity
FBF36_RS10465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FBF36_RS10470	COG0713	ATP synthesis coupled electron transport
FBF36_RS10480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FBF36_RS10485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FBF36_RS10490	COG1034	ATP synthesis coupled electron transport
FBF36_RS10495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FBF36_RS10505	COG0649	NAD binding
FBF36_RS10510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FBF36_RS10515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FBF36_RS10525	COG0644	oxidoreductase
FBF36_RS10530	COG2226	methyltransferase
FBF36_RS10535	COG1169	isochorismate synthase
FBF36_RS10540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FBF36_RS10545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FBF36_RS10550	COG4948	Mandelate Racemase Muconate Lactonizing
FBF36_RS10555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FBF36_RS10575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FBF36_RS10610	COG1378	Sugar-specific transcriptional regulator TrmB
FBF36_RS10635	COG4176	ABC-type proline glycine betaine transport system permease component
FBF36_RS10645	COG1940	carbohydrate kinase activity
FBF36_RS10650	COG5426	von Willebrand factor, type A
FBF36_RS10660	COG1175	transmembrane transport
FBF36_RS10665	COG0395	ABC-type sugar transport system, permease component
FBF36_RS10670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FBF36_RS10680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FBF36_RS10685	COG2235	arginine
FBF36_RS10700	COG2197	response regulator
FBF36_RS10705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FBF36_RS10730	COG3477	response to acidic pH
FBF36_RS10750	COG1397	ADP-ribosylglycohydrolase
FBF36_RS10755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FBF36_RS10775	COG0406	alpha-ribazole phosphatase activity
FBF36_RS10780	COG2171	N-acyltransferase activity
FBF36_RS10845	COG1217	gtp-binding protein TYPA
FBF36_RS10880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FBF36_RS10890	COG2267	carboxylic ester hydrolase activity
FBF36_RS10905	COG1902	pentaerythritol trinitrate reductase activity
FBF36_RS10910	COG1733	regulation of RNA biosynthetic process
FBF36_RS10915	COG0604	alcohol dehydrogenase
FBF36_RS10920	COG3012	SEC-C Motif Domain Protein
FBF36_RS10925	COG1362	aminopeptidase activity
FBF36_RS10930	COG0546	phosphoglycolate phosphatase activity
FBF36_RS10945	COG0501	Belongs to the peptidase M48B family
FBF36_RS11050	COG3177	Filamentation induced by cAMP protein fic
FBF36_RS11055	COG0698	ribose 5-phosphate isomerase
FBF36_RS11080	COG0596	Alpha beta hydrolase
FBF36_RS11080	COG0508	dehydrogenase complex catalyzes the overall conversion of
FBF36_RS11095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FBF36_RS11100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FBF36_RS11100	COG0574	Belongs to the PEP-utilizing enzyme family
FBF36_RS11115	COG2211	Major facilitator Superfamily
FBF36_RS11130	COG0438	transferase activity, transferring glycosyl groups
FBF36_RS11130	COG0297	glycogen (starch) synthase activity
FBF36_RS11235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FBF36_RS11240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FBF36_RS11240	COG3433	isochorismatase activity
FBF36_RS11240	COG2226	methyltransferase
FBF36_RS11245	COG3433	isochorismatase activity
FBF36_RS11245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FBF36_RS11245	COG2226	methyltransferase
FBF36_RS11260	COG1136	(ABC) transporter
FBF36_RS11280	COG1490	D-aminoacyl-tRNA deacylase activity
FBF36_RS11290	COG0354	folic acid binding
FBF36_RS11295	COG3485	protocatechuate 3,4-dioxygenase
FBF36_RS11305	COG0745	RESPONSE REGULATOR receiver
FBF36_RS11310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FBF36_RS11330	COG0494	nUDIX hydrolase
FBF36_RS11330	COG0406	alpha-ribazole phosphatase activity
FBF36_RS11335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FBF36_RS11380	COG0513	Belongs to the DEAD box helicase family
FBF36_RS11395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FBF36_RS11405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FBF36_RS11420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FBF36_RS11440	COG0431	NADPH-dependent FMN reductase
FBF36_RS11445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FBF36_RS11455	COG0667	Aldo Keto reductase
FBF36_RS11465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FBF36_RS11480	COG0444	Belongs to the ABC transporter superfamily
FBF36_RS11485	COG0129	dihydroxy-acid dehydratase activity
FBF36_RS11515	COG4585	Histidine kinase
FBF36_RS11520	COG2197	response regulator
FBF36_RS11525	COG0193	aminoacyl-tRNA hydrolase activity
FBF36_RS11530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FBF36_RS11555	COG0710	3-dehydroquinate dehydratase activity
FBF36_RS11575	COG0148	phosphopyruvate hydratase activity
FBF36_RS11615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FBF36_RS11630	COG1309	transcriptional regulator
FBF36_RS11720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FBF36_RS11725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FBF36_RS11725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FBF36_RS11735	COG0714	Associated with various cellular activities
FBF36_RS11780	COG0488	(ABC) transporter
FBF36_RS11785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FBF36_RS11790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FBF36_RS11805	COG0084	hydrolase, TatD family'
FBF36_RS11810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FBF36_RS11820	COG1335	isochorismatase
FBF36_RS11840	COG0697	spore germination
FBF36_RS11845	COG0583	DNA-binding transcription factor activity
FBF36_RS11870	COG2197	response regulator
FBF36_RS11890	COG1297	OPT oligopeptide transporter protein
FBF36_RS11900	COG2814	Major facilitator Superfamily
FBF36_RS11905	COG0640	Transcriptional regulator
FBF36_RS11910	COG1215	transferase activity, transferring glycosyl groups
FBF36_RS11935	COG1959	2 iron, 2 sulfur cluster binding
FBF36_RS11985	COG3852	Histidine kinase
FBF36_RS12035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FBF36_RS12045	COG1970	mechanosensitive ion channel activity
FBF36_RS12070	COG1388	LysM domain
FBF36_RS12070	COG3103	Sh3 type 3 domain protein
FBF36_RS12070	COG0791	NLP P60 protein
FBF36_RS12125	COG2252	PERMEase
FBF36_RS12130	COG1201	RNA secondary structure unwinding
FBF36_RS12150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FBF36_RS12155	COG0590	tRNA wobble adenosine to inosine editing
FBF36_RS12160	COG2076	Multidrug Resistance protein
FBF36_RS12180	COG1061	Type III restriction enzyme res subunit
FBF36_RS12200	COG1842	Phage shock protein A
FBF36_RS12210	COG0745	RESPONSE REGULATOR receiver
FBF36_RS12215	COG2205	protein histidine kinase activity
FBF36_RS12230	COG0459	protein refolding
FBF36_RS12245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FBF36_RS12250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FBF36_RS12255	COG0215	cysteine-tRNA ligase activity
FBF36_RS12260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FBF36_RS12290	COG3842	ATPase activity
FBF36_RS12355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FBF36_RS12390	COG3716	PTS system mannose fructose sorbose family IID component
FBF36_RS12395	COG3715	PTS system
FBF36_RS12400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FBF36_RS12400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FBF36_RS12405	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FBF36_RS12420	COG1621	beta-fructofuranosidase activity
FBF36_RS12425	COG1609	Transcriptional regulator
FBF36_RS12430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FBF36_RS12445	COG0542	response to heat
FBF36_RS12470	COG0577	efflux transmembrane transporter activity
FBF36_RS12470	COG1136	(ABC) transporter
FBF36_RS12490	COG0745	RESPONSE REGULATOR receiver
FBF36_RS12495	COG2205	protein histidine kinase activity
FBF36_RS12515	COG0789	Transcriptional regulator
FBF36_RS12520	COG0484	heat shock protein binding
FBF36_RS12525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FBF36_RS12530	COG0443	Heat shock 70 kDa protein
FBF36_RS12540	COG2814	Major facilitator Superfamily
FBF36_RS12545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FBF36_RS12550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS12600	COG0778	Nitroreductase
FBF36_RS12705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FBF36_RS12780	COG3842	ATPase activity
FBF36_RS12800	COG1733	regulation of RNA biosynthetic process
FBF36_RS12815	COG0247	lactate metabolic process
FBF36_RS12815	COG2181	nitrate reductase activity
FBF36_RS12840	COG2197	response regulator
FBF36_RS12845	COG4585	Histidine kinase
FBF36_RS12885	COG0483	inositol monophosphate 1-phosphatase activity
FBF36_RS12890	COG1113	amino acid transport
FBF36_RS12900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FBF36_RS12905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FBF36_RS12910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FBF36_RS12910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FBF36_RS12915	COG1940	carbohydrate kinase activity
FBF36_RS12920	COG4607	ABC-type enterochelin transport system periplasmic component
FBF36_RS12925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS12930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FBF36_RS12935	COG1120	ATPase activity
FBF36_RS12955	COG0628	permease
FBF36_RS12965	COG1854	S-ribosylhomocysteine lyase activity
FBF36_RS12975	COG2409	Drug exporters of the RND superfamily
FBF36_RS12995	COG1733	regulation of RNA biosynthetic process
FBF36_RS13010	COG0789	Transcriptional regulator
FBF36_RS13015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FBF36_RS13020	COG0569	domain protein
FBF36_RS13020	COG2985	domain, Protein
FBF36_RS13025	COG1966	Carbon starvation protein
FBF36_RS13045	COG1716	ATPase activity
FBF36_RS13050	COG1716	ATPase activity
FBF36_RS13065	COG0768	penicillin binding
FBF36_RS13070	COG0515	serine threonine protein kinase
FBF36_RS13075	COG2815	serine threonine protein kinase
FBF36_RS13075	COG0515	serine threonine protein kinase
FBF36_RS13080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FBF36_RS13085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FBF36_RS13095	COG3345	alpha-galactosidase
FBF36_RS13100	COG0673	inositol 2-dehydrogenase activity
FBF36_RS13105	COG0617	tRNA 3'-terminal CCA addition
FBF36_RS13120	COG0728	peptidoglycan biosynthetic process
FBF36_RS13125	COG0492	ferredoxin-NADP+ reductase activity
FBF36_RS13130	COG3118	belongs to the thioredoxin family
FBF36_RS13135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FBF36_RS13140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FBF36_RS13145	COG1181	Belongs to the D-alanine--D-alanine ligase family
FBF36_RS13160	COG1192	Involved in chromosome partitioning
FBF36_RS13165	COG0357	Ribosomal RNA small subunit methyltransferase G
FBF36_RS13175	COG0706	membrane insertase activity
FBF36_RS13180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FBF36_RS13185	COG0594	ribonuclease P activity
FBF36_RS13190	COG0230	Belongs to the bacterial ribosomal protein bL34 family