locus-tag	class	description
FFB31_RS00005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FFB31_RS00015	COG1288	antiporter activity
FFB31_RS00020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FFB31_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
FFB31_RS00060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FFB31_RS00100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FFB31_RS00105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FFB31_RS00110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FFB31_RS00130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FFB31_RS00135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FFB31_RS00145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FFB31_RS00150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FFB31_RS00155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FFB31_RS00160	COG0540	Belongs to the ATCase OTCase family
FFB31_RS00165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FFB31_RS00170	COG0284	orotidine-5'-phosphate decarboxylase activity
FFB31_RS00175	COG0194	GDP metabolic process
FFB31_RS00180	COG1758	RNA polymerase activity
FFB31_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FFB31_RS00205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FFB31_RS00215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FFB31_RS00220	COG3409	Peptidoglycan-binding domain 1 protein
FFB31_RS00235	COG2814	Major facilitator Superfamily
FFB31_RS00240	COG1309	transcriptional regulator
FFB31_RS00245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FFB31_RS00250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFB31_RS00255	COG1063	alcohol dehydrogenase
FFB31_RS00280	COG4581	dead DEAH box helicase
FFB31_RS00290	COG1216	Glycosyl transferase, family 2
FFB31_RS00300	COG0443	Heat shock 70 kDa protein
FFB31_RS00320	COG1716	ATPase activity
FFB31_RS00330	COG1201	RNA secondary structure unwinding
FFB31_RS00340	COG0300	oxidoreductase activity
FFB31_RS00365	COG0488	(ABC) transporter
FFB31_RS00380	COG1160	GTP binding
FFB31_RS00385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FFB31_RS00395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FFB31_RS00430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FFB31_RS00435	COG0149	triose-phosphate isomerase activity
FFB31_RS00440	COG0126	phosphoglycerate kinase activity
FFB31_RS00450	COG1481	regulation of sporulation
FFB31_RS00455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FFB31_RS00460	COG1660	Displays ATPase and GTPase activities
FFB31_RS00465	COG0322	excinuclease ABC activity
FFB31_RS00490	COG0556	nucleotide-excision repair
FFB31_RS00495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FFB31_RS00495	COG0237	dephospho-CoA kinase activity
FFB31_RS00500	COG0656	L-ascorbic acid biosynthetic process
FFB31_RS00505	COG3622	Belongs to the hyi family
FFB31_RS00510	COG3960	tartronate-semialdehyde synthase activity
FFB31_RS00520	COG0540	Belongs to the ATCase OTCase family
FFB31_RS00525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FFB31_RS00530	COG1414	Transcriptional regulator
FFB31_RS00535	COG1953	Uracil, thiamine, allantoin
FFB31_RS00550	COG0539	negative regulation of cytoplasmic translation
FFB31_RS00555	COG2226	methyltransferase
FFB31_RS00585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FFB31_RS00595	COG0133	tryptophan synthase activity
FFB31_RS00600	COG0134	indole-3-glycerol-phosphate synthase activity
FFB31_RS00615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FFB31_RS00650	COG1968	undecaprenyl-diphosphatase activity
FFB31_RS00655	COG0667	Aldo Keto reductase
FFB31_RS00665	COG1404	Belongs to the peptidase S8 family
FFB31_RS00670	COG1404	Belongs to the peptidase S8 family
FFB31_RS00680	COG0339	signal peptide processing
FFB31_RS00710	COG0587	DNA-directed DNA polymerase activity
FFB31_RS00715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FFB31_RS00725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FFB31_RS00750	COG1119	ATPase activity
FFB31_RS00755	COG0297	glycogen (starch) synthase activity
FFB31_RS00775	COG1131	(ABC) transporter
FFB31_RS00790	COG0488	(ABC) transporter
FFB31_RS00800	COG2151	metal-sulfur cluster biosynthetic enzyme
FFB31_RS00815	COG0396	ATPase activity
FFB31_RS00825	COG0719	Fe-S assembly protein
FFB31_RS00865	COG0497	DNA recombination
FFB31_RS00870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FFB31_RS00880	COG0647	UMP catabolic process
FFB31_RS00905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FFB31_RS00915	COG1438	arginine binding
FFB31_RS00925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FFB31_RS00930	COG0124	histidyl-tRNA synthetase
FFB31_RS00935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FFB31_RS00940	COG1196	nuclear chromosome segregation
FFB31_RS00950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FFB31_RS00955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FFB31_RS00960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFB31_RS00965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFB31_RS00975	COG2255	four-way junction helicase activity
FFB31_RS00980	COG0632	four-way junction helicase activity
FFB31_RS00985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FFB31_RS00990	COG0217	transcriptional regulatory protein
FFB31_RS01015	COG0494	nUDIX hydrolase
FFB31_RS01030	COG0438	transferase activity, transferring glycosyl groups
FFB31_RS01035	COG1560	Kdo2-lipid A biosynthetic process
FFB31_RS01050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FFB31_RS01105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FFB31_RS01110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FFB31_RS01120	COG0569	domain protein
FFB31_RS01155	COG1435	thymidine kinase activity
FFB31_RS01170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FFB31_RS01180	COG0187	DNA topoisomerase II activity
FFB31_RS01190	COG2176	DNA-directed DNA polymerase activity
FFB31_RS01195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFB31_RS01200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FFB31_RS01200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FFB31_RS01205	COG0509	glycine decarboxylation via glycine cleavage system
FFB31_RS01210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FFB31_RS01250	COG0741	lytic transglycosylase activity
FFB31_RS01255	COG0515	serine threonine protein kinase
FFB31_RS01255	COG2815	serine threonine protein kinase
FFB31_RS01260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FFB31_RS01265	COG0205	6-phosphofructokinase activity
FFB31_RS01275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FFB31_RS01315	COG0167	dihydroorotate dehydrogenase activity
FFB31_RS01325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FFB31_RS01335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FFB31_RS01340	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFB31_RS01350	COG0174	glutamine synthetase
FFB31_RS01360	COG0765	amino acid transport
FFB31_RS01375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FFB31_RS01380	COG0174	glutamine synthetase
FFB31_RS01390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FFB31_RS01405	COG3022	response to hydroperoxide
FFB31_RS01415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FFB31_RS01450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FFB31_RS01455	COG0393	Putative heavy-metal-binding
FFB31_RS01465	COG0009	L-threonylcarbamoyladenylate synthase
FFB31_RS01485	COG0456	acetyltransferase
FFB31_RS01540	COG0358	DNA primase activity
FFB31_RS01575	COG0423	glycine-tRNA ligase activity
FFB31_RS01585	COG1121	(ABC) transporter
FFB31_RS01590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFB31_RS01630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FFB31_RS01645	COG1799	cell septum assembly
FFB31_RS01650	COG1496	oxidoreductase activity
FFB31_RS01655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FFB31_RS01665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FFB31_RS01670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FFB31_RS01680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FFB31_RS01685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FFB31_RS01690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FFB31_RS01695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FFB31_RS01700	COG0768	penicillin binding
FFB31_RS01710	COG0275	rRNA processing
FFB31_RS01715	COG2001	Belongs to the MraZ family
FFB31_RS01725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FFB31_RS01745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FFB31_RS01750	COG0318	PFAM AMP-dependent synthetase and ligase
FFB31_RS01760	COG1619	proteins homologs of microcin C7 resistance protein MccF
FFB31_RS01765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FFB31_RS01775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FFB31_RS01790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FFB31_RS01795	COG2813	Specifically methylates the guanine in position
FFB31_RS01810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FFB31_RS01820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FFB31_RS01825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FFB31_RS01830	COG2137	regulation of response to DNA damage stimulus
FFB31_RS01835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FFB31_RS01845	COG1396	sequence-specific DNA binding
FFB31_RS01850	COG1058	Belongs to the CinA family
FFB31_RS01850	COG1546	Belongs to the CinA family
FFB31_RS01865	COG1674	ftsk spoiiie
FFB31_RS01870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FFB31_RS01875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FFB31_RS01890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FFB31_RS01905	COG0612	Peptidase, M16
FFB31_RS01910	COG1185	polyribonucleotide nucleotidyltransferase activity
FFB31_RS01915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FFB31_RS01930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FFB31_RS01935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FFB31_RS01940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FFB31_RS01955	COG0779	Required for maturation of 30S ribosomal subunits
FFB31_RS01965	COG0442	prolyl-tRNA aminoacylation
FFB31_RS01970	COG0456	acetyltransferase
FFB31_RS01975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FFB31_RS01995	COG0750	zinc metalloprotease
FFB31_RS02000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FFB31_RS02010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FFB31_RS02020	COG0233	cytoplasmic translational termination
FFB31_RS02025	COG0528	UMP kinase activity
FFB31_RS02030	COG2818	Glycosylase
FFB31_RS02035	COG3830	Belongs to the UPF0237 family
FFB31_RS02040	COG2848	UPF0210 protein
FFB31_RS02045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FFB31_RS02050	COG0052	Belongs to the universal ribosomal protein uS2 family
FFB31_RS02060	COG0371	Dehydrogenase
FFB31_RS02065	COG1069	ribulokinase activity
FFB31_RS02070	COG4974	Belongs to the 'phage' integrase family
FFB31_RS02085	COG0792	nuclease activity
FFB31_RS02100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FFB31_RS02105	COG0681	Belongs to the peptidase S26 family
FFB31_RS02110	COG0335	large ribosomal subunit rRNA binding
FFB31_RS02115	COG0336	Belongs to the RNA methyltransferase TrmD family
FFB31_RS02120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FFB31_RS02125	COG1837	Belongs to the UPF0109 family
FFB31_RS02130	COG0228	four-way junction DNA binding
FFB31_RS02135	COG3177	Filamentation induced by cAMP protein fic
FFB31_RS02140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FFB31_RS02205	COG1196	nuclear chromosome segregation
FFB31_RS02210	COG1174	glycine betaine transport
FFB31_RS02220	COG1174	glycine betaine transport
FFB31_RS02235	COG0105	UTP biosynthetic process
FFB31_RS02245	COG0285	dihydrofolate synthase activity
FFB31_RS02250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FFB31_RS02270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FFB31_RS02285	COG0525	valine-tRNA ligase activity
FFB31_RS02290	COG1022	Amp-dependent synthetase and ligase
FFB31_RS02295	COG1605	Chorismate mutase
FFB31_RS02295	COG0287	Prephenate dehydrogenase
FFB31_RS02300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FFB31_RS02305	COG0740	serine-type endopeptidase activity
FFB31_RS02315	COG0544	peptidyl-prolyl cis-trans isomerase activity
FFB31_RS02325	COG2885	chlorophyll binding
FFB31_RS02370	COG1309	transcriptional regulator
FFB31_RS02375	COG2409	Drug exporters of the RND superfamily
FFB31_RS02380	COG1511	domain protein
FFB31_RS02395	COG1739	Uncharacterized protein family UPF0029
FFB31_RS02405	COG1045	serine acetyltransferase
FFB31_RS02410	COG0698	ribose 5-phosphate isomerase
FFB31_RS02415	COG3590	peptidase
FFB31_RS02420	COG3590	peptidase
FFB31_RS02445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FFB31_RS02445	COG2190	(PTS) system
FFB31_RS02445	COG1263	PTS System
FFB31_RS02450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FFB31_RS02460	COG1946	Acyl-CoA thioesterase
FFB31_RS02470	COG0629	single-stranded DNA binding
FFB31_RS02495	COG1126	abc transporter atp-binding protein
FFB31_RS02500	COG0765	amino acid transport
FFB31_RS02505	COG0765	amino acid transport
FFB31_RS02510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FFB31_RS02525	COG2814	Major facilitator Superfamily
FFB31_RS02540	COG1121	(ABC) transporter
FFB31_RS02550	COG0515	serine threonine protein kinase
FFB31_RS02605	COG1309	transcriptional regulator
FFB31_RS02625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FFB31_RS02635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FFB31_RS02640	COG0473	3-isopropylmalate dehydrogenase activity
FFB31_RS02665	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FFB31_RS02695	COG2949	membrane
FFB31_RS02710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FFB31_RS02730	COG0569	domain protein
FFB31_RS02730	COG2985	domain, Protein
FFB31_RS02735	COG0129	dihydroxy-acid dehydratase activity
FFB31_RS02740	COG2837	iron assimilation
FFB31_RS02755	COG1132	(ABC) transporter
FFB31_RS02760	COG1132	(ABC) transporter
FFB31_RS02765	COG4868	Belongs to the UPF0371 family
FFB31_RS02815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FFB31_RS02820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FFB31_RS02825	COG0154	amidase activity
FFB31_RS02830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FFB31_RS02835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FFB31_RS02840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FFB31_RS02845	COG4585	Histidine kinase
FFB31_RS02850	COG2197	response regulator
FFB31_RS02855	COG4181	ATPase activity
FFB31_RS02880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FFB31_RS02915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FFB31_RS02920	COG2382	esterase
FFB31_RS02925	COG2056	Na+-H+ antiporter family
FFB31_RS02930	COG4977	sequence-specific DNA binding
FFB31_RS02935	COG1335	isochorismatase
FFB31_RS02950	COG3250	beta-galactosidase activity
FFB31_RS02955	COG1609	Transcriptional regulator
FFB31_RS02960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FFB31_RS02980	COG4974	Belongs to the 'phage' integrase family
FFB31_RS03055	COG0629	single-stranded DNA binding
FFB31_RS03060	COG4626	Terminase
FFB31_RS03060	COG1802	Transcriptional regulator
FFB31_RS03085	COG1615	UPF0182 protein
FFB31_RS03095	COG3480	Lon protease (S16) C-terminal proteolytic domain
FFB31_RS03185	COG0366	Alpha amylase catalytic
FFB31_RS03195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FFB31_RS03205	COG0366	Alpha amylase catalytic
FFB31_RS03240	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FFB31_RS03250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FFB31_RS03255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FFB31_RS03260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FFB31_RS03265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FFB31_RS03270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FFB31_RS03275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FFB31_RS03280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FFB31_RS03285	COG0356	it plays a direct role in the translocation of protons across the membrane
FFB31_RS03305	COG2890	protein-(glutamine-N5) methyltransferase activity
FFB31_RS03310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FFB31_RS03325	COG0083	homoserine kinase activity
FFB31_RS03330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FFB31_RS03335	COG0460	homoserine dehydrogenase
FFB31_RS03350	COG0018	arginyl-trna synthetase
FFB31_RS03365	COG0741	lytic transglycosylase activity
FFB31_RS03365	COG1196	nuclear chromosome segregation
FFB31_RS03365	COG0739	heme binding
FFB31_RS03370	COG0567	Dehydrogenase, E1 component
FFB31_RS03370	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFB31_RS03405	COG1595	DNA-templated transcription, initiation
FFB31_RS03415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FFB31_RS03420	COG1162	GTPase activity
FFB31_RS03425	COG0483	inositol monophosphate 1-phosphatase activity
FFB31_RS03430	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FFB31_RS03435	COG0420	3'-5' exonuclease activity
FFB31_RS03445	COG0419	ATPase involved in DNA repair
FFB31_RS03450	COG1621	beta-fructofuranosidase activity
FFB31_RS03485	COG0653	protein targeting
FFB31_RS03490	COG0737	Belongs to the 5'-nucleotidase family
FFB31_RS03500	COG2188	Transcriptional regulator
FFB31_RS03505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FFB31_RS03505	COG2190	(PTS) system
FFB31_RS03505	COG1263	PTS System
FFB31_RS03510	COG0366	Alpha amylase catalytic
FFB31_RS03545	COG0142	geranyltranstransferase activity
FFB31_RS03550	COG1007	ATP synthesis coupled electron transport
FFB31_RS03565	COG0713	ATP synthesis coupled electron transport
FFB31_RS03570	COG0839	Belongs to the complex I subunit 6 family
FFB31_RS03575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFB31_RS03580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FFB31_RS03585	COG1034	ATP synthesis coupled electron transport
FFB31_RS03590	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FFB31_RS03600	COG0649	NAD binding
FFB31_RS03605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFB31_RS03610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFB31_RS03620	COG0644	oxidoreductase
FFB31_RS03625	COG2226	methyltransferase
FFB31_RS03630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FFB31_RS03640	COG1575	Belongs to the MenA family. Type 1 subfamily
FFB31_RS03665	COG0406	alpha-ribazole phosphatase activity
FFB31_RS03685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FFB31_RS03690	COG0569	domain protein
FFB31_RS03695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FFB31_RS03705	COG1194	a g-specific adenine glycosylase
FFB31_RS03710	COG2390	Transcriptional regulator
FFB31_RS03715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FFB31_RS03720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FFB31_RS03730	COG1131	(ABC) transporter
FFB31_RS03750	COG1595	DNA-templated transcription, initiation
FFB31_RS03775	COG1620	l-lactate permease
FFB31_RS03780	COG0247	lactate metabolic process
FFB31_RS03790	COG1556	Lactate utilization protein
FFB31_RS03825	COG1136	(ABC) transporter
FFB31_RS03835	COG0745	RESPONSE REGULATOR receiver
FFB31_RS03870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FFB31_RS03900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FFB31_RS03905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FFB31_RS03940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FFB31_RS03945	COG0302	gtp cyclohydrolase
FFB31_RS03950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFB31_RS03960	COG0037	tRNA processing
FFB31_RS03970	COG2027	D-alanyl-D-alanine carboxypeptidase
FFB31_RS03975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FFB31_RS03995	COG2873	o-acetylhomoserine
FFB31_RS04000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FFB31_RS04060	COG0277	FAD linked oxidase domain protein
FFB31_RS04060	COG0247	lactate metabolic process
FFB31_RS04080	COG0574	Belongs to the PEP-utilizing enzyme family
FFB31_RS04080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFB31_RS04155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FFB31_RS04200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FFB31_RS04205	COG1070	Carbohydrate kinase
FFB31_RS04210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FFB31_RS04215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FFB31_RS04235	COG1070	Carbohydrate kinase
FFB31_RS04250	COG0698	ribose 5-phosphate isomerase
FFB31_RS04255	COG1349	DNA-binding transcription factor activity
FFB31_RS04270	COG1490	D-aminoacyl-tRNA deacylase activity
FFB31_RS04285	COG3485	protocatechuate 3,4-dioxygenase
FFB31_RS04330	COG2391	methyltransferase activity
FFB31_RS04335	COG0425	Belongs to the sulfur carrier protein TusA family
FFB31_RS04345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FFB31_RS04360	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FFB31_RS04370	COG0783	Belongs to the Dps family
FFB31_RS04400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFB31_RS04435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFB31_RS04435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FFB31_RS04485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FFB31_RS04495	COG0557	exoribonuclease II activity
FFB31_RS04510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FFB31_RS04510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FFB31_RS04515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FFB31_RS04530	COG1136	(ABC) transporter
FFB31_RS04530	COG0577	efflux transmembrane transporter activity
FFB31_RS04545	COG1309	transcriptional regulator
FFB31_RS04560	COG1349	DNA-binding transcription factor activity
FFB31_RS04565	COG1070	Carbohydrate kinase
FFB31_RS04570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FFB31_RS04575	COG0235	Class ii aldolase
FFB31_RS04580	COG0366	Alpha amylase catalytic
FFB31_RS04600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FFB31_RS04605	COG0047	phosphoribosylformylglycinamidine synthase activity
FFB31_RS04615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FFB31_RS04630	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FFB31_RS04645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FFB31_RS04650	COG0058	SHG alpha-glucan phosphorylase activity
FFB31_RS04675	COG0191	fructose-bisphosphate aldolase activity
FFB31_RS04685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FFB31_RS04695	COG1704	LemA family
FFB31_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
FFB31_RS04720	COG0708	Exodeoxyribonuclease III
FFB31_RS04755	COG1924	4 iron, 4 sulfur cluster binding
FFB31_RS04770	COG0667	Aldo Keto reductase
FFB31_RS04790	COG1960	acyl-CoA dehydrogenase activity
FFB31_RS04875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FFB31_RS04880	COG0395	ABC-type sugar transport system, permease component
FFB31_RS04885	COG1175	transmembrane transport
FFB31_RS04895	COG2188	Transcriptional regulator
FFB31_RS04930	COG1674	ftsk spoiiie
FFB31_RS04950	COG1404	Belongs to the peptidase S8 family
FFB31_RS04955	COG1193	negative regulation of DNA recombination
FFB31_RS04975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FFB31_RS04990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FFB31_RS04995	COG0789	Transcriptional regulator
FFB31_RS05000	COG0484	heat shock protein binding
FFB31_RS05005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FFB31_RS05010	COG0443	Heat shock 70 kDa protein
FFB31_RS05055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFB31_RS05060	COG1121	(ABC) transporter
FFB31_RS05065	COG0803	Belongs to the bacterial solute-binding protein 9 family
FFB31_RS05100	COG1115	amino acid carrier protein
FFB31_RS05110	COG0515	serine threonine protein kinase
FFB31_RS05110	COG2815	serine threonine protein kinase
FFB31_RS05140	COG0714	Associated with various cellular activities
FFB31_RS05155	COG0343	queuine tRNA-ribosyltransferase activity
FFB31_RS05175	COG3265	gluconokinase activity
FFB31_RS05185	COG2814	Major facilitator Superfamily
FFB31_RS05215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FFB31_RS05220	COG0805	protein transport
FFB31_RS05225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FFB31_RS05290	COG0314	molybdopterin synthase activity
FFB31_RS05300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FFB31_RS05340	COG4592	Periplasmic binding protein
FFB31_RS05345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FFB31_RS05350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FFB31_RS05355	COG1120	ATPase activity
FFB31_RS05400	COG0351	phosphomethylpyrimidine kinase
FFB31_RS05405	COG0305	Participates in initiation and elongation during chromosome replication
FFB31_RS05415	COG2084	Dehydrogenase
FFB31_RS05440	COG1136	(ABC) transporter
FFB31_RS05455	COG0359	binds to the 23S rRNA
FFB31_RS05460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FFB31_RS05470	COG0360	Binds together with S18 to 16S ribosomal RNA
FFB31_RS05475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FFB31_RS05480	COG0628	permease
FFB31_RS05490	COG0617	tRNA 3'-terminal CCA addition
FFB31_RS05510	COG0492	ferredoxin-NADP+ reductase activity
FFB31_RS05525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FFB31_RS05530	COG1181	Belongs to the D-alanine--D-alanine ligase family
FFB31_RS05545	COG0357	Ribosomal RNA small subunit methyltransferase G
FFB31_RS05555	COG0706	membrane insertase activity
FFB31_RS05560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FFB31_RS05565	COG0594	ribonuclease P activity
FFB31_RS05570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FFB31_RS05575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FFB31_RS05580	COG0592	DNA-directed DNA polymerase activity
FFB31_RS05585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FFB31_RS05590	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FFB31_RS05595	COG0187	DNA topoisomerase II activity
FFB31_RS05600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FFB31_RS05645	COG0640	Transcriptional regulator
FFB31_RS05655	COG1476	TRANSCRIPTIONal
FFB31_RS05670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FFB31_RS05675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FFB31_RS05675	COG3253	May function as heme-dependent peroxidase
FFB31_RS05680	COG0604	alcohol dehydrogenase
FFB31_RS05705	COG3764	Sortase (surface protein transpeptidase)
FFB31_RS05715	COG0515	serine threonine protein kinase
FFB31_RS05720	COG0768	penicillin binding
FFB31_RS05735	COG1716	ATPase activity
FFB31_RS05740	COG1716	ATPase activity
FFB31_RS05770	COG1132	(ABC) transporter
FFB31_RS05775	COG1131	(ABC) transporter
FFB31_RS05795	COG1132	(ABC) transporter
FFB31_RS05800	COG1132	(ABC) transporter
FFB31_RS05815	COG0328	RNA-DNA hybrid ribonuclease activity
FFB31_RS05830	COG1131	(ABC) transporter
FFB31_RS05850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FFB31_RS05855	COG1854	S-ribosylhomocysteine lyase activity
FFB31_RS05865	COG1760	l-serine dehydratase
FFB31_RS05870	COG0626	cystathionine gamma-synthase activity
FFB31_RS05875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FFB31_RS05920	COG1780	Probably involved in ribonucleotide reductase function
FFB31_RS05925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FFB31_RS05935	COG0517	IMP dehydrogenase activity
FFB31_RS05935	COG1125	glycine betaine transport
FFB31_RS05940	COG1174	glycine betaine transport
FFB31_RS05945	COG1174	glycine betaine transport
FFB31_RS05970	COG4104	PAAR repeat-containing protein
FFB31_RS06020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FFB31_RS06035	COG1175	transmembrane transport
FFB31_RS06050	COG0747	negative chemotaxis
FFB31_RS06060	COG0444	Belongs to the ABC transporter superfamily
FFB31_RS06065	COG4608	Belongs to the ABC transporter superfamily
FFB31_RS06070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FFB31_RS06080	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FFB31_RS06100	COG1643	Atp-dependent helicase
FFB31_RS06115	COG2860	membrane
FFB31_RS06120	COG2084	Dehydrogenase
FFB31_RS06125	COG1929	Belongs to the glycerate kinase type-1 family
FFB31_RS06150	COG0800	Aldolase
FFB31_RS06155	COG1063	alcohol dehydrogenase
FFB31_RS06160	COG2610	gluconate transmembrane transporter activity
FFB31_RS06170	COG0246	Mannitol dehydrogenase
FFB31_RS06210	COG1063	alcohol dehydrogenase
FFB31_RS06235	COG4585	Histidine kinase
FFB31_RS06245	COG3579	cysteine-type endopeptidase activity
FFB31_RS06255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FFB31_RS06265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FFB31_RS06270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FFB31_RS06315	COG0586	Pfam SNARE associated Golgi protein
FFB31_RS06320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FFB31_RS06345	COG0789	Transcriptional regulator
FFB31_RS06350	COG1950	PFAM Membrane protein of
FFB31_RS06355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FFB31_RS06370	COG0714	Associated with various cellular activities
FFB31_RS06405	COG0494	nUDIX hydrolase
FFB31_RS06425	COG0717	Belongs to the dCTP deaminase family
FFB31_RS06445	COG3842	ATPase activity
FFB31_RS06475	COG1940	carbohydrate kinase activity
FFB31_RS06550	COG0561	phosphatase activity
FFB31_RS06555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FFB31_RS06560	COG1803	Methylglyoxal synthase
FFB31_RS06560	COG1597	lipid kinase activity
FFB31_RS06565	COG0077	Prephenate dehydratase
FFB31_RS06585	COG1215	transferase activity, transferring glycosyl groups
FFB31_RS06605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FFB31_RS06650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FFB31_RS06660	COG1131	(ABC) transporter
FFB31_RS06665	COG2197	response regulator
FFB31_RS06680	COG1131	(ABC) transporter
FFB31_RS06685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FFB31_RS06730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FFB31_RS06740	COG0251	oxidation-reduction process
FFB31_RS06755	COG0596	Alpha beta hydrolase
FFB31_RS06820	COG1205	dead DEAH box helicase
FFB31_RS06820	COG1111	helicase
FFB31_RS06875	COG2094	Belongs to the DNA glycosylase MPG family
FFB31_RS06890	COG2890	protein-(glutamine-N5) methyltransferase activity
FFB31_RS06895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FFB31_RS06900	COG1754	DNA topoisomerase type I activity
FFB31_RS06900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FFB31_RS06905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FFB31_RS06980	COG2376	Dihydroxyacetone kinase
FFB31_RS07000	COG1113	amino acid transport
FFB31_RS07005	COG0588	phosphoglycerate mutase activity
FFB31_RS07010	COG1329	Transcriptional regulator
FFB31_RS07015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FFB31_RS07020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FFB31_RS07025	COG2249	NAD(P)H dehydrogenase (quinone) activity
FFB31_RS07035	COG0215	cysteine-tRNA ligase activity
FFB31_RS07040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FFB31_RS07065	COG2233	PERMEase
FFB31_RS07075	COG0778	Nitroreductase
FFB31_RS07135	COG3842	ATPase activity
FFB31_RS07155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FFB31_RS07190	COG0459	protein refolding
FFB31_RS07205	COG2937	Belongs to the GPAT DAPAT family
FFB31_RS07210	COG2205	protein histidine kinase activity
FFB31_RS07215	COG0745	RESPONSE REGULATOR receiver
FFB31_RS07220	COG1842	Phage shock protein A
FFB31_RS07230	COG1278	Cold shock
FFB31_RS07245	COG2252	PERMEase
FFB31_RS07265	COG1388	LysM domain
FFB31_RS07265	COG0791	NLP P60 protein
FFB31_RS07295	COG1970	mechanosensitive ion channel activity
FFB31_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
FFB31_RS07340	COG3321	synthase
FFB31_RS07340	COG0604	alcohol dehydrogenase
FFB31_RS07380	COG0640	Transcriptional regulator
FFB31_RS07395	COG1063	alcohol dehydrogenase
FFB31_RS07405	COG0667	Aldo Keto reductase
FFB31_RS07420	COG0789	Transcriptional regulator
FFB31_RS07420	COG4978	Transcriptional regulator
FFB31_RS07430	COG1136	(ABC) transporter
FFB31_RS07430	COG0577	efflux transmembrane transporter activity
FFB31_RS07445	COG1309	transcriptional regulator
FFB31_RS07460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FFB31_RS07475	COG2267	carboxylic ester hydrolase activity
FFB31_RS07480	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FFB31_RS07480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FFB31_RS07510	COG1733	regulation of RNA biosynthetic process
FFB31_RS07515	COG2910	NAD(P)H-binding
FFB31_RS07520	COG0640	Transcriptional regulator
FFB31_RS07525	COG2814	Major facilitator Superfamily
FFB31_RS07545	COG3158	transport of potassium into the cell
FFB31_RS07565	COG1285	pathogenesis
FFB31_RS07605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFB31_RS07610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFB31_RS07640	COG0561	phosphatase activity
FFB31_RS07645	COG1335	isochorismatase
FFB31_RS07650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FFB31_RS07655	COG0084	hydrolase, TatD family'
FFB31_RS07690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FFB31_RS07700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FFB31_RS07705	COG0488	(ABC) transporter
FFB31_RS07725	COG4152	abc transporter atp-binding protein
FFB31_RS07740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FFB31_RS07770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FFB31_RS07775	COG0193	aminoacyl-tRNA hydrolase activity
FFB31_RS07790	COG0148	phosphopyruvate hydratase activity
FFB31_RS07795	COG0277	FAD linked oxidase domain protein
FFB31_RS07815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FFB31_RS07860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFB31_RS07865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FFB31_RS07875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FFB31_RS07885	COG1722	exodeoxyribonuclease VII activity
FFB31_RS07890	COG1570	exodeoxyribonuclease VII activity
FFB31_RS07895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FFB31_RS07905	COG1322	Protein conserved in bacteria
FFB31_RS07925	COG0012	GTP binding
FFB31_RS08085	COG2814	Major facilitator Superfamily
FFB31_RS08100	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FFB31_RS08110	COG2249	NAD(P)H dehydrogenase (quinone) activity
FFB31_RS08145	COG1522	sequence-specific DNA binding
FFB31_RS08165	COG2197	response regulator
FFB31_RS08190	COG0114	fumarate hydratase activity
FFB31_RS08200	COG0840	transmembrane signaling receptor activity
FFB31_RS08205	COG2354	Protein conserved in bacteria
FFB31_RS08210	COG2314	TM2 domain
FFB31_RS08215	COG3477	response to acidic pH
FFB31_RS08225	COG1113	amino acid transport
FFB31_RS08235	COG3189	MarR family transcriptional regulator
FFB31_RS08240	COG1362	aminopeptidase activity
FFB31_RS08245	COG0318	PFAM AMP-dependent synthetase and ligase
FFB31_RS08250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FFB31_RS08255	COG0321	lipoyl(octanoyl) transferase activity
FFB31_RS08265	COG0601	transmembrane transport
FFB31_RS08285	COG1217	gtp-binding protein TYPA
FFB31_RS08310	COG3311	Transcriptional regulator
FFB31_RS08315	COG2171	N-acyltransferase activity
FFB31_RS08345	COG0745	RESPONSE REGULATOR receiver
FFB31_RS08350	COG2205	protein histidine kinase activity
FFB31_RS08365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FFB31_RS08370	COG1316	TRANSCRIPTIONal
FFB31_RS08375	COG1316	TRANSCRIPTIONal
FFB31_RS08390	COG1088	dTDP-glucose 4,6-dehydratase activity
FFB31_RS08395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FFB31_RS08400	COG0463	Glycosyl transferase, family 2
FFB31_RS08435	COG3754	Rhamnan synthesis protein F
FFB31_RS08450	COG0463	Glycosyl transferase, family 2
FFB31_RS08470	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FFB31_RS08510	COG2835	tetraacyldisaccharide 4'-kinase activity
FFB31_RS08515	COG0745	RESPONSE REGULATOR receiver
FFB31_RS08520	COG5000	phosphorelay sensor kinase activity
FFB31_RS08520	COG5002	protein histidine kinase activity
FFB31_RS08525	COG5401	PFAM Sporulation and spore germination
FFB31_RS08535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FFB31_RS08545	COG1666	GTP binding
FFB31_RS08565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FFB31_RS08570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FFB31_RS08575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FFB31_RS08580	COG4585	Histidine kinase
FFB31_RS08585	COG4585	Histidine kinase
FFB31_RS08600	COG0436	Aminotransferase
FFB31_RS08610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FFB31_RS08615	COG0250	Participates in transcription elongation, termination and antitermination
FFB31_RS08620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FFB31_RS08625	COG0081	regulation of translation
FFB31_RS08655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FFB31_RS08660	COG0222	ribosome binding
FFB31_RS08665	COG0085	RNA polymerase activity
FFB31_RS08670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FFB31_RS08675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FFB31_RS08680	COG0049	tRNA binding
FFB31_RS08685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FFB31_RS08690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FFB31_RS08700	COG2226	methyltransferase
FFB31_RS08705	COG0051	transcription antitermination factor activity, RNA binding
FFB31_RS08710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FFB31_RS08715	COG0088	Forms part of the polypeptide exit tunnel
FFB31_RS08720	COG0089	rRNA binding
FFB31_RS08725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FFB31_RS08730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FFB31_RS08735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FFB31_RS08740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FFB31_RS08745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FFB31_RS08750	COG0255	Belongs to the universal ribosomal protein uL29 family
FFB31_RS08755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FFB31_RS08760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FFB31_RS08765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FFB31_RS08770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FFB31_RS08775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FFB31_RS08780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FFB31_RS08785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FFB31_RS08795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FFB31_RS08800	COG1841	ribosomal large subunit assembly
FFB31_RS08805	COG0200	Binds to the 23S rRNA
FFB31_RS08815	COG0563	adenylate kinase activity
FFB31_RS08880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FFB31_RS08885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FFB31_RS08890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FFB31_RS08895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FFB31_RS08900	COG0202	RNA polymerase activity
FFB31_RS08905	COG0203	ribosomal protein L17
FFB31_RS08910	COG1966	Carbon starvation protein
FFB31_RS08945	COG0101	tRNA pseudouridine synthase activity
FFB31_RS08975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FFB31_RS08980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FFB31_RS09015	COG1072	(Pantothenic acid kinase))
FFB31_RS09020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FFB31_RS09025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FFB31_RS09025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FFB31_RS09030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FFB31_RS09035	COG0802	atpase or kinase
FFB31_RS09060	COG1053	succinate dehydrogenase
FFB31_RS09065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FFB31_RS09080	COG0789	Transcriptional regulator
FFB31_RS09095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FFB31_RS09105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FFB31_RS09110	COG0315	cyclic pyranopterin monophosphate synthase activity
FFB31_RS09115	COG0303	'Molybdopterin
FFB31_RS09120	COG0314	molybdopterin synthase activity
FFB31_RS09135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FFB31_RS09140	COG1140	nitrate reductase beta subunit
FFB31_RS09160	COG0521	Mo-molybdopterin cofactor biosynthetic process
FFB31_RS09185	COG0516	GMP reductase activity
FFB31_RS09190	COG0726	polysaccharide deacetylase
FFB31_RS09200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FFB31_RS09200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FFB31_RS09215	COG1131	(ABC) transporter
FFB31_RS09265	COG2030	dehydratase
FFB31_RS09270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FFB31_RS09280	COG2086	electron transfer activity
FFB31_RS09285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FFB31_RS09290	COG0644	oxidoreductase
FFB31_RS09315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FFB31_RS09330	COG0519	Catalyzes the synthesis of GMP from XMP
FFB31_RS09330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FFB31_RS09340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FFB31_RS09350	COG1882	Formate acetyltransferase
FFB31_RS09360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FFB31_RS09365	COG3585	molybdate ion transport
FFB31_RS09390	COG1902	pentaerythritol trinitrate reductase activity
FFB31_RS09410	COG0840	transmembrane signaling receptor activity
FFB31_RS09415	COG0045	succinate-CoA ligase (ADP-forming) activity
FFB31_RS09450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FFB31_RS09455	COG0363	glucosamine-6-phosphate deaminase activity
FFB31_RS09480	COG0138	bifunctional purine biosynthesis protein purh
FFB31_RS09485	COG1012	belongs to the aldehyde dehydrogenase family
FFB31_RS09490	COG2902	Dehydrogenase
FFB31_RS09500	COG0833	amino acid
FFB31_RS09515	COG0733	neurotransmitter:sodium symporter activity
FFB31_RS09525	COG1113	amino acid transport
FFB31_RS09530	COG1113	amino acid transport
FFB31_RS09535	COG1297	OPT oligopeptide transporter protein
FFB31_RS09540	COG1253	flavin adenine dinucleotide binding
FFB31_RS09545	COG0205	6-phosphofructokinase activity
FFB31_RS09575	COG0166	Belongs to the GPI family
FFB31_RS09590	COG0039	L-malate dehydrogenase activity
FFB31_RS09600	COG4770	biotin carboxylase activity
FFB31_RS09605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FFB31_RS09630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FFB31_RS09635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FFB31_RS09655	COG1744	ABC transporter substrate-binding protein PnrA-like
FFB31_RS09660	COG3845	ABC transporter
FFB31_RS09665	COG4603	Belongs to the binding-protein-dependent transport system permease family
FFB31_RS09670	COG1079	Belongs to the binding-protein-dependent transport system permease family
FFB31_RS09685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FFB31_RS09690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FFB31_RS09700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FFB31_RS09705	COG1611	Belongs to the LOG family
FFB31_RS09720	COG2151	metal-sulfur cluster biosynthetic enzyme
FFB31_RS09720	COG0489	protein tyrosine kinase activity
FFB31_RS09730	COG2239	Acts as a magnesium transporter
FFB31_RS09735	COG0006	proline dipeptidase activity
FFB31_RS09740	COG0613	PHP domain protein
FFB31_RS09745	COG2095	MarC family integral membrane protein
FFB31_RS09760	COG0463	Glycosyl transferase, family 2
FFB31_RS09770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FFB31_RS09800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FFB31_RS09805	COG2884	Cell division ATP-binding protein ftsE
FFB31_RS09810	COG2177	Part of the ABC transporter FtsEX involved in
FFB31_RS09815	COG0739	heme binding
FFB31_RS09820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FFB31_RS09860	COG0392	lysyltransferase activity
FFB31_RS09860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FFB31_RS09890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FFB31_RS09900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FFB31_RS09905	COG1234	tRNA 3'-trailer cleavage
FFB31_RS09910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FFB31_RS09915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FFB31_RS09940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FFB31_RS09945	COG1022	Amp-dependent synthetase and ligase
FFB31_RS09960	COG1136	(ABC) transporter
FFB31_RS09970	COG2197	response regulator
FFB31_RS09975	COG2235	arginine
FFB31_RS09980	COG1834	amidinotransferase
FFB31_RS09985	COG0477	Major facilitator Superfamily
FFB31_RS10005	COG1131	(ABC) transporter
FFB31_RS10015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FFB31_RS10050	COG0438	transferase activity, transferring glycosyl groups
FFB31_RS10065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FFB31_RS10070	COG0066	3-isopropylmalate dehydratase activity
FFB31_RS10075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FFB31_RS10095	COG1181	Belongs to the D-alanine--D-alanine ligase family
FFB31_RS10100	COG0431	NADPH-dependent FMN reductase
FFB31_RS10110	COG2814	Major facilitator Superfamily
FFB31_RS10130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FFB31_RS10135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FFB31_RS10140	COG0742	ribosomal rna small subunit methyltransferase
FFB31_RS10160	COG0571	ribonuclease III activity
FFB31_RS10175	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FFB31_RS10185	COG1294	oxidase, subunit
FFB31_RS10190	COG1271	oxidase subunit
FFB31_RS10195	COG1530	ribonuclease E activity
FFB31_RS10200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FFB31_RS10205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FFB31_RS10210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FFB31_RS10220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FFB31_RS10225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FFB31_RS10235	COG0799	negative regulation of ribosome biogenesis
FFB31_RS10240	COG0406	alpha-ribazole phosphatase activity
FFB31_RS10255	COG2267	carboxylic ester hydrolase activity
FFB31_RS10270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FFB31_RS10280	COG1464	Belongs to the NlpA lipoprotein family
FFB31_RS10285	COG2011	ABC-type metal ion transport system permease component
FFB31_RS10300	COG0813	purine-nucleoside phosphorylase activity
FFB31_RS10325	COG0495	leucyl-tRNA aminoacylation
FFB31_RS10335	COG0433	COG0433 Predicted ATPase
FFB31_RS10340	COG1596	polysaccharide export
FFB31_RS10340	COG1555	photosystem II stabilization
FFB31_RS10355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FFB31_RS10360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FFB31_RS10365	COG0561	phosphatase activity
FFB31_RS10370	COG4191	Histidine kinase
FFB31_RS10395	COG1131	(ABC) transporter
FFB31_RS10405	COG0268	Binds directly to 16S ribosomal RNA
FFB31_RS10425	COG0481	GTPase activity
FFB31_RS10430	COG2258	MOSC domain
FFB31_RS10435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FFB31_RS10455	COG1420	regulation of RNA biosynthetic process
FFB31_RS10460	COG0484	heat shock protein binding
FFB31_RS10465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FFB31_RS10475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FFB31_RS10510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FFB31_RS10515	COG1381	Involved in DNA repair and RecF pathway recombination
FFB31_RS10520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FFB31_RS10535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FFB31_RS10545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FFB31_RS10550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FFB31_RS10560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FFB31_RS10570	COG2197	response regulator