locus-tag	class	description
C3V41_RS00010	COG0714	Associated with various cellular activities
C3V41_RS00075	COG1674	ftsk spoiiie
C3V41_RS00130	COG0328	RNA-DNA hybrid ribonuclease activity
C3V41_RS00135	COG2197	response regulator
C3V41_RS00140	COG4585	Histidine kinase
C3V41_RS00155	COG1131	(ABC) transporter
C3V41_RS00180	COG1609	Transcriptional regulator
C3V41_RS00185	COG2814	Major facilitator Superfamily
C3V41_RS00190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3V41_RS00190	COG0519	Catalyzes the synthesis of GMP from XMP
C3V41_RS00225	COG1131	(ABC) transporter
C3V41_RS00230	COG4585	Histidine kinase
C3V41_RS00235	COG2197	response regulator
C3V41_RS00245	COG0667	Aldo Keto reductase
C3V41_RS00265	COG0656	L-ascorbic acid biosynthetic process
C3V41_RS00270	COG3620	sequence-specific DNA binding
C3V41_RS00275	COG2814	Major facilitator Superfamily
C3V41_RS00285	COG3541	Predicted nucleotidyltransferase
C3V41_RS00305	COG0789	Transcriptional regulator
C3V41_RS00305	COG4978	Transcriptional regulator
C3V41_RS00360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3V41_RS00390	COG2205	protein histidine kinase activity
C3V41_RS00395	COG0745	RESPONSE REGULATOR receiver
C3V41_RS00410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3V41_RS00415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V41_RS00425	COG2190	(PTS) system
C3V41_RS00430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V41_RS00435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V41_RS00440	COG2188	Transcriptional regulator
C3V41_RS00445	COG1263	PTS System
C3V41_RS00470	COG1131	(ABC) transporter
C3V41_RS00480	COG3590	peptidase
C3V41_RS00505	COG1045	serine acetyltransferase
C3V41_RS00515	COG1739	Uncharacterized protein family UPF0029
C3V41_RS00535	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3V41_RS00555	COG1116	anion transmembrane transporter activity
C3V41_RS00560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3V41_RS00570	COG0740	serine-type endopeptidase activity
C3V41_RS00575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3V41_RS00580	COG0287	Prephenate dehydrogenase
C3V41_RS00580	COG1605	Chorismate mutase
C3V41_RS00615	COG1129	ABC transporter
C3V41_RS00625	COG1122	ATPase activity
C3V41_RS00630	COG2375	cellular response to nickel ion
C3V41_RS00630	COG1132	(ABC) transporter
C3V41_RS00635	COG1132	(ABC) transporter
C3V41_RS00640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3V41_RS00645	COG0366	Alpha amylase catalytic
C3V41_RS00650	COG1263	PTS System
C3V41_RS00650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V41_RS00650	COG2190	(PTS) system
C3V41_RS00655	COG2188	Transcriptional regulator
C3V41_RS00670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3V41_RS00675	COG0154	amidase activity
C3V41_RS00680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3V41_RS00690	COG0052	Belongs to the universal ribosomal protein uS2 family
C3V41_RS00695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3V41_RS00715	COG0233	cytoplasmic translational termination
C3V41_RS00725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3V41_RS00735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3V41_RS00740	COG0750	zinc metalloprotease
C3V41_RS00755	COG2233	PERMEase
C3V41_RS00765	COG0657	acetylesterase activity
C3V41_RS00770	COG2188	Transcriptional regulator
C3V41_RS00775	COG0747	negative chemotaxis
C3V41_RS00785	COG0444	Belongs to the ABC transporter superfamily
C3V41_RS00790	COG4608	Belongs to the ABC transporter superfamily
C3V41_RS00795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3V41_RS00800	COG1940	carbohydrate kinase activity
C3V41_RS00805	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C3V41_RS00825	COG0363	glucosamine-6-phosphate deaminase activity
C3V41_RS00840	COG0596	Alpha beta hydrolase
C3V41_RS00840	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3V41_RS00850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3V41_RS00880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3V41_RS00885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3V41_RS00935	COG3304	Inner membrane component domain
C3V41_RS00940	COG0456	acetyltransferase
C3V41_RS00945	COG1162	GTPase activity
C3V41_RS00950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3V41_RS00955	COG2838	Isocitrate dehydrogenase
C3V41_RS00965	COG2304	oxidoreductase activity
C3V41_RS00975	COG1595	DNA-templated transcription, initiation
C3V41_RS01000	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3V41_RS01000	COG0567	Dehydrogenase, E1 component
C3V41_RS01030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V41_RS01035	COG4604	ABC transporter, ATP-binding protein
C3V41_RS01040	COG4605	iron ion homeostasis
C3V41_RS01045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V41_RS01050	COG4607	ABC-type enterochelin transport system periplasmic component
C3V41_RS01065	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3V41_RS01080	COG0018	arginyl-trna synthetase
C3V41_RS01085	COG0019	diaminopimelate decarboxylase activity
C3V41_RS01105	COG0460	homoserine dehydrogenase
C3V41_RS01110	COG0083	homoserine kinase activity
C3V41_RS01130	COG0254	rRNA binding
C3V41_RS01135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3V41_RS01145	COG2161	toxin-antitoxin pair type II binding
C3V41_RS01150	COG4115	mRNA cleavage
C3V41_RS01215	COG1595	DNA-templated transcription, initiation
C3V41_RS01240	COG1175	transmembrane transport
C3V41_RS01250	COG0366	Alpha amylase catalytic
C3V41_RS01260	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3V41_RS01275	COG0205	6-phosphofructokinase activity
C3V41_RS01375	COG0045	succinate-CoA ligase (ADP-forming) activity
C3V41_RS01410	COG0596	Alpha beta hydrolase
C3V41_RS01415	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C3V41_RS01420	COG1132	(ABC) transporter
C3V41_RS01425	COG1132	(ABC) transporter
C3V41_RS01430	COG0039	L-malate dehydrogenase activity
C3V41_RS01440	COG1725	Transcriptional regulator
C3V41_RS01465	COG0058	SHG alpha-glucan phosphorylase activity
C3V41_RS01475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3V41_RS01530	COG2197	response regulator
C3V41_RS01540	COG1131	(ABC) transporter
C3V41_RS01570	COG0442	prolyl-tRNA aminoacylation
C3V41_RS01585	COG0779	Required for maturation of 30S ribosomal subunits
C3V41_RS01600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3V41_RS01600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3V41_RS01615	COG1546	Belongs to the CinA family
C3V41_RS01615	COG1058	Belongs to the CinA family
C3V41_RS01620	COG1396	sequence-specific DNA binding
C3V41_RS01630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3V41_RS01645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C3V41_RS01655	COG0577	efflux transmembrane transporter activity
C3V41_RS01655	COG1136	(ABC) transporter
C3V41_RS01670	COG2249	NAD(P)H dehydrogenase (quinone) activity
C3V41_RS01675	COG0509	glycine decarboxylation via glycine cleavage system
C3V41_RS01680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3V41_RS01715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3V41_RS01730	COG0672	)-iron permease
C3V41_RS01750	COG0577	efflux transmembrane transporter activity
C3V41_RS01775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3V41_RS01780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3V41_RS01785	COG1114	Component of the transport system for branched-chain amino acids
C3V41_RS01790	COG0477	Major facilitator Superfamily
C3V41_RS01800	COG2813	Specifically methylates the guanine in position
C3V41_RS01835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3V41_RS01845	COG0318	PFAM AMP-dependent synthetase and ligase
C3V41_RS01850	COG0318	PFAM AMP-dependent synthetase and ligase
C3V41_RS01870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3V41_RS01875	COG1285	pathogenesis
C3V41_RS01885	COG2001	Belongs to the MraZ family
C3V41_RS01890	COG0275	rRNA processing
C3V41_RS01900	COG0768	penicillin binding
C3V41_RS01905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3V41_RS01910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3V41_RS01915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3V41_RS01920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3V41_RS01935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3V41_RS01950	COG1496	oxidoreductase activity
C3V41_RS01955	COG1799	cell septum assembly
C3V41_RS01965	COG3599	regulation of cell shape
C3V41_RS01970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3V41_RS01980	COG2153	protein acetylation
C3V41_RS01985	COG0587	DNA-directed DNA polymerase activity
C3V41_RS01990	COG2501	S4 domain
C3V41_RS02035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3V41_RS02105	COG1074	ATP-dependent DNA helicase activity
C3V41_RS02125	COG0025	NhaP-type Na H and K H
C3V41_RS02145	COG0131	Imidazoleglycerol-phosphate dehydratase
C3V41_RS02160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3V41_RS02165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3V41_RS02180	COG3845	ABC transporter
C3V41_RS02190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3V41_RS02195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3V41_RS02200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3V41_RS02205	COG1126	abc transporter atp-binding protein
C3V41_RS02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3V41_RS02215	COG0765	amino acid transport
C3V41_RS02220	COG0765	amino acid transport
C3V41_RS02225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V41_RS02245	COG1131	(ABC) transporter
C3V41_RS02285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3V41_RS02295	COG1438	arginine binding
C3V41_RS02300	COG0137	argininosuccinate synthase activity
C3V41_RS02310	COG3307	-O-antigen
C3V41_RS02320	COG0165	Argininosuccinate lyase
C3V41_RS02325	COG2094	Belongs to the DNA glycosylase MPG family
C3V41_RS02340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3V41_RS02380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3V41_RS02385	COG0497	DNA recombination
C3V41_RS02420	COG0494	nUDIX hydrolase
C3V41_RS02440	COG0396	ATPase activity
C3V41_RS02450	COG0822	iron-sulfur transferase activity
C3V41_RS02455	COG2151	metal-sulfur cluster biosynthetic enzyme
C3V41_RS02460	COG3189	MarR family transcriptional regulator
C3V41_RS02480	COG0167	dihydroorotate dehydrogenase activity
C3V41_RS02485	COG0667	Aldo Keto reductase
C3V41_RS02510	COG0366	Alpha amylase catalytic
C3V41_RS02515	COG3833	ABC-type maltose transport systems, permease component
C3V41_RS02525	COG2182	Extracellular solute-binding protein
C3V41_RS02540	COG0358	DNA primase activity
C3V41_RS02545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3V41_RS02575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3V41_RS02605	COG1420	regulation of RNA biosynthetic process
C3V41_RS02610	COG0484	heat shock protein binding
C3V41_RS02665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3V41_RS02675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3V41_RS02690	COG1476	TRANSCRIPTIONal
C3V41_RS02700	COG1131	(ABC) transporter
C3V41_RS02705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3V41_RS02710	COG1381	Involved in DNA repair and RecF pathway recombination
C3V41_RS02715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3V41_RS02725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V41_RS02730	COG1116	anion transmembrane transporter activity
C3V41_RS02740	COG0423	glycine-tRNA ligase activity
C3V41_RS02750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3V41_RS02765	COG3830	Belongs to the UPF0237 family
C3V41_RS02765	COG0560	Phosphoserine phosphatase
C3V41_RS02775	COG0297	glycogen (starch) synthase activity
C3V41_RS02785	COG1119	ATPase activity
C3V41_RS02820	COG0488	(ABC) transporter
C3V41_RS02860	COG0515	serine threonine protein kinase
C3V41_RS02860	COG2815	serine threonine protein kinase
C3V41_RS02865	COG0142	geranyltranstransferase activity
C3V41_RS02870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3V41_RS02875	COG1160	GTP binding
C3V41_RS02890	COG0166	Belongs to the GPI family
C3V41_RS02965	COG0561	phosphatase activity
C3V41_RS02985	COG0363	glucosamine-6-phosphate deaminase activity
C3V41_RS03000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3V41_RS03025	COG0443	Heat shock 70 kDa protein
C3V41_RS03040	COG1621	beta-fructofuranosidase activity
C3V41_RS03045	COG1263	PTS System
C3V41_RS03045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V41_RS03045	COG2190	(PTS) system
C3V41_RS03060	COG0546	phosphoglycolate phosphatase activity
C3V41_RS03080	COG0205	6-phosphofructokinase activity
C3V41_RS03105	COG0805	protein transport
C3V41_RS03110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3V41_RS03130	COG0140	phosphoribosyl-ATP diphosphatase activity
C3V41_RS03135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3V41_RS03145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3V41_RS03150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3V41_RS03155	COG1881	PFAM PEBP family protein
C3V41_RS03165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3V41_RS03175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3V41_RS03215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3V41_RS03220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C3V41_RS03225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3V41_RS03230	COG0531	amino acid
C3V41_RS03235	COG0569	domain protein
C3V41_RS03285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3V41_RS03295	COG0187	DNA topoisomerase II activity
C3V41_RS03325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3V41_RS03330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C3V41_RS03345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3V41_RS03350	COG0149	triose-phosphate isomerase activity
C3V41_RS03360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3V41_RS03365	COG1481	regulation of sporulation
C3V41_RS03375	COG1660	Displays ATPase and GTPase activities
C3V41_RS03390	COG1263	PTS System
C3V41_RS03390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V41_RS03390	COG2190	(PTS) system
C3V41_RS03400	COG0322	excinuclease ABC activity
C3V41_RS03405	COG0561	phosphatase activity
C3V41_RS03430	COG0483	inositol monophosphate 1-phosphatase activity
C3V41_RS03470	COG1929	Belongs to the glycerate kinase type-1 family
C3V41_RS03475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3V41_RS03485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3V41_RS03490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3V41_RS03495	COG4770	biotin carboxylase activity
C3V41_RS03505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3V41_RS03515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3V41_RS03525	COG0366	Alpha amylase catalytic
C3V41_RS03525	COG1470	cell adhesion involved in biofilm formation
C3V41_RS03535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3V41_RS03545	COG1758	RNA polymerase activity
C3V41_RS03550	COG0194	GDP metabolic process
C3V41_RS03555	COG0194	GDP metabolic process
C3V41_RS03560	COG0284	orotidine-5'-phosphate decarboxylase activity
C3V41_RS03565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3V41_RS03570	COG0505	Belongs to the CarA family
C3V41_RS03575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3V41_RS03580	COG0540	Belongs to the ATCase OTCase family
C3V41_RS03585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3V41_RS03595	COG0702	epimerase
C3V41_RS03600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3V41_RS03605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3V41_RS03620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3V41_RS03625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3V41_RS03630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3V41_RS03640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3V41_RS03650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3V41_RS03660	COG2409	Drug exporters of the RND superfamily
C3V41_RS03665	COG0009	L-threonylcarbamoyladenylate synthase
C3V41_RS03680	COG0640	Transcriptional regulator
C3V41_RS03690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3V41_RS03720	COG4651	solute:proton antiporter activity
C3V41_RS03720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3V41_RS03725	COG0124	histidyl-tRNA synthetase
C3V41_RS03730	COG0556	nucleotide-excision repair
C3V41_RS03745	COG0237	dephospho-CoA kinase activity
C3V41_RS03765	COG0539	negative regulation of cytoplasmic translation
C3V41_RS03775	COG2050	protein possibly involved in aromatic compounds catabolism
C3V41_RS03800	COG0134	indole-3-glycerol-phosphate synthase activity
C3V41_RS03815	COG0107	imidazoleglycerol-phosphate synthase activity
C3V41_RS03825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3V41_RS03835	COG4122	O-methyltransferase activity
C3V41_RS03840	COG1222	aaa ATPase
C3V41_RS03855	COG0517	IMP dehydrogenase activity
C3V41_RS03855	COG1994	Peptidase M50
C3V41_RS03865	COG0656	L-ascorbic acid biosynthetic process
C3V41_RS03875	COG1252	NADH dehydrogenase
C3V41_RS03890	COG0477	Major facilitator Superfamily
C3V41_RS03900	COG0628	permease
C3V41_RS03910	COG0676	glucose-6-phosphate 1-epimerase activity
C3V41_RS03915	COG0546	phosphoglycolate phosphatase activity
C3V41_RS03925	COG0671	phosphoesterase, PA-phosphatase related
C3V41_RS03980	COG1882	Formate acetyltransferase
C3V41_RS03995	COG0038	chloride channel
C3V41_RS04015	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3V41_RS04025	COG0321	lipoyl(octanoyl) transferase activity
C3V41_RS04030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3V41_RS04065	COG0765	amino acid transport
C3V41_RS04070	COG1126	abc transporter atp-binding protein
C3V41_RS04080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3V41_RS04085	COG0174	glutamine synthetase
C3V41_RS04100	COG0488	(ABC) transporter
C3V41_RS04115	COG1196	nuclear chromosome segregation
C3V41_RS04125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3V41_RS04130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3V41_RS04135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3V41_RS04140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3V41_RS04150	COG2255	four-way junction helicase activity
C3V41_RS04155	COG0632	four-way junction helicase activity
C3V41_RS04160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3V41_RS04165	COG0217	transcriptional regulatory protein
C3V41_RS04170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3V41_RS04175	COG0494	nUDIX hydrolase
C3V41_RS04180	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C3V41_RS04200	COG0438	transferase activity, transferring glycosyl groups
C3V41_RS04205	COG1560	Kdo2-lipid A biosynthetic process
C3V41_RS04210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3V41_RS04220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3V41_RS04225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3V41_RS04250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3V41_RS04255	COG0481	GTPase activity
C3V41_RS04265	COG0133	tryptophan synthase activity
C3V41_RS04275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3V41_RS04285	COG0159	tryptophan synthase activity
C3V41_RS04310	COG1122	ATPase activity
C3V41_RS04315	COG0268	Binds directly to 16S ribosomal RNA
C3V41_RS04320	COG4868	Belongs to the UPF0371 family
C3V41_RS04335	COG2183	response to ionizing radiation
C3V41_RS04340	COG1307	EDD domain protein, DegV family
C3V41_RS04345	COG0495	leucyl-tRNA aminoacylation
C3V41_RS04350	COG0537	adenosine 5'-monophosphoramidase activity
C3V41_RS04380	COG0733	neurotransmitter:sodium symporter activity
C3V41_RS04385	COG0813	purine-nucleoside phosphorylase activity
C3V41_RS04435	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3V41_RS04440	COG1027	Aspartate ammonia-lyase
C3V41_RS04450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3V41_RS04470	COG0714	Associated with various cellular activities
C3V41_RS04495	COG0406	alpha-ribazole phosphatase activity
C3V41_RS04500	COG0799	negative regulation of ribosome biogenesis
C3V41_RS04510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3V41_RS04515	COG1349	DNA-binding transcription factor activity
C3V41_RS04530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3V41_RS04535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3V41_RS04540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3V41_RS04545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3V41_RS04550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3V41_RS04555	COG1530	ribonuclease E activity
C3V41_RS04560	COG1271	oxidase subunit
C3V41_RS04565	COG1294	oxidase, subunit
C3V41_RS04570	COG0641	radical SAM
C3V41_RS04590	COG4988	ABC transporter
C3V41_RS04595	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C3V41_RS04610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3V41_RS04615	COG0571	ribonuclease III activity
C3V41_RS04630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3V41_RS04640	COG3119	arylsulfatase activity
C3V41_RS04645	COG1609	Transcriptional regulator
C3V41_RS04650	COG2814	Major facilitator Superfamily
C3V41_RS04660	COG1461	Dihydroxyacetone kinase
C3V41_RS04665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3V41_RS04695	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3V41_RS04705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3V41_RS04715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3V41_RS04730	COG0438	transferase activity, transferring glycosyl groups
C3V41_RS04735	COG1132	(ABC) transporter
C3V41_RS04750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3V41_RS04755	COG5002	protein histidine kinase activity
C3V41_RS04760	COG0745	RESPONSE REGULATOR receiver
C3V41_RS04770	COG0066	3-isopropylmalate dehydratase activity
C3V41_RS04810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3V41_RS04820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3V41_RS04840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3V41_RS04850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3V41_RS04855	COG0612	Peptidase, M16
C3V41_RS04860	COG1185	polyribonucleotide nucleotidyltransferase activity
C3V41_RS04880	COG2814	Major facilitator Superfamily
C3V41_RS04885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3V41_RS04890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3V41_RS04900	COG1674	ftsk spoiiie
C3V41_RS04905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3V41_RS04905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3V41_RS04915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3V41_RS04945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3V41_RS04960	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3V41_RS04965	COG1115	amino acid carrier protein
C3V41_RS04970	COG1115	amino acid carrier protein
C3V41_RS04980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3V41_RS05000	COG0739	heme binding
C3V41_RS05010	COG2884	Cell division ATP-binding protein ftsE
C3V41_RS05035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C3V41_RS05040	COG0515	serine threonine protein kinase
C3V41_RS05045	COG0515	serine threonine protein kinase
C3V41_RS05050	COG1716	ATPase activity
C3V41_RS05050	COG1131	(ABC) transporter
C3V41_RS05050	COG0842	Transport permease protein
C3V41_RS05065	COG0473	3-isopropylmalate dehydrogenase activity
C3V41_RS05070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3V41_RS05085	COG0569	domain protein
C3V41_RS05085	COG2985	domain, Protein
C3V41_RS05095	COG0549	Belongs to the carbamate kinase family
C3V41_RS05100	COG0708	Exodeoxyribonuclease III
C3V41_RS05130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3V41_RS05150	COG0315	cyclic pyranopterin monophosphate synthase activity
C3V41_RS05155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3V41_RS05155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3V41_RS05160	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3V41_RS05160	COG0315	cyclic pyranopterin monophosphate synthase activity
C3V41_RS05175	COG1140	nitrate reductase beta subunit
C3V41_RS05205	COG1132	(ABC) transporter
C3V41_RS05210	COG1132	(ABC) transporter
C3V41_RS05210	COG2375	cellular response to nickel ion
C3V41_RS05215	COG1129	ABC transporter
C3V41_RS05230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C3V41_RS05240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V41_RS05240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V41_RS05255	COG1120	ATPase activity
C3V41_RS05265	COG2249	NAD(P)H dehydrogenase (quinone) activity
C3V41_RS05275	COG1063	alcohol dehydrogenase
C3V41_RS05280	COG0483	inositol monophosphate 1-phosphatase activity
C3V41_RS05285	COG1968	undecaprenyl-diphosphatase activity
C3V41_RS05290	COG0420	3'-5' exonuclease activity
C3V41_RS05295	COG0419	ATPase involved in DNA repair
C3V41_RS05300	COG4750	Nucleotidyl transferase
C3V41_RS05305	COG0697	spore germination
C3V41_RS05350	COG0653	protein targeting
C3V41_RS05355	COG1040	competence protein
C3V41_RS05360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3V41_RS05365	COG5401	PFAM Sporulation and spore germination
C3V41_RS05375	COG0745	RESPONSE REGULATOR receiver
C3V41_RS05395	COG0714	Associated with various cellular activities
C3V41_RS05415	COG1663	tetraacyldisaccharide 4'-kinase activity
C3V41_RS05415	COG2835	tetraacyldisaccharide 4'-kinase activity
C3V41_RS05455	COG1482	cell wall glycoprotein biosynthetic process
C3V41_RS05465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3V41_RS05470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3V41_RS05500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3V41_RS05505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3V41_RS05510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3V41_RS05515	COG0254	rRNA binding
C3V41_RS05520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3V41_RS05525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3V41_RS05535	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C3V41_RS05545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3V41_RS05550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3V41_RS05555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3V41_RS05560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3V41_RS05565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3V41_RS05570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3V41_RS05580	COG0356	it plays a direct role in the translocation of protons across the membrane
C3V41_RS05605	COG2197	response regulator
C3V41_RS05625	COG0693	protein deglycase activity
C3V41_RS05640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C3V41_RS05655	COG0513	Belongs to the DEAD box helicase family
C3V41_RS05660	COG2095	MarC family integral membrane protein
C3V41_RS05670	COG0673	inositol 2-dehydrogenase activity
C3V41_RS05680	COG0006	proline dipeptidase activity
C3V41_RS05700	COG0714	Associated with various cellular activities
C3V41_RS05705	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C3V41_RS05730	COG2239	Acts as a magnesium transporter
C3V41_RS05740	COG2755	lipolytic protein G-D-S-L family
C3V41_RS05740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3V41_RS05750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3V41_RS05760	COG0673	inositol 2-dehydrogenase activity
C3V41_RS05770	COG1175	transmembrane transport
C3V41_RS05775	COG0395	ABC-type sugar transport system, permease component
C3V41_RS05785	COG0285	dihydrofolate synthase activity
C3V41_RS05800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3V41_RS05810	COG0346	lactoylglutathione lyase activity
C3V41_RS05825	COG1174	glycine betaine transport
C3V41_RS05830	COG0517	IMP dehydrogenase activity
C3V41_RS05830	COG1125	glycine betaine transport
C3V41_RS05850	COG0114	fumarate hydratase activity
C3V41_RS05855	COG2315	Protein conserved in bacteria
C3V41_RS05875	COG1397	ADP-ribosylglycohydrolase
C3V41_RS05900	COG1674	ftsk spoiiie
C3V41_RS05945	COG1349	DNA-binding transcription factor activity
C3V41_RS05950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3V41_RS05965	COG1136	(ABC) transporter
C3V41_RS05965	COG0577	efflux transmembrane transporter activity
C3V41_RS05995	COG3475	LICD family
C3V41_RS06015	COG0463	Glycosyl transferase, family 2
C3V41_RS06045	COG1216	Glycosyl transferase, family 2
C3V41_RS06055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3V41_RS06055	COG2755	lipolytic protein G-D-S-L family
C3V41_RS06120	COG1316	TRANSCRIPTIONal
C3V41_RS06125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3V41_RS06155	COG5002	protein histidine kinase activity
C3V41_RS06160	COG0745	RESPONSE REGULATOR receiver
C3V41_RS06190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3V41_RS06210	COG1666	GTP binding
C3V41_RS06215	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3V41_RS06220	COG0501	Belongs to the peptidase M48B family
C3V41_RS06225	COG0686	Belongs to the AlaDH PNT family
C3V41_RS06235	COG2017	converts alpha-aldose to the beta-anomer
C3V41_RS06265	COG4974	Belongs to the 'phage' integrase family
C3V41_RS06280	COG0792	nuclease activity
C3V41_RS06290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3V41_RS06295	COG0681	Belongs to the peptidase S26 family
C3V41_RS06315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3V41_RS06320	COG1837	Belongs to the UPF0109 family
C3V41_RS06325	COG0228	four-way junction DNA binding
C3V41_RS06335	COG1131	(ABC) transporter
C3V41_RS06360	COG4585	Histidine kinase
C3V41_RS06365	COG2197	response regulator
C3V41_RS06380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3V41_RS06385	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C3V41_RS06395	COG1194	a g-specific adenine glycosylase
C3V41_RS06405	COG2197	response regulator
C3V41_RS06415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3V41_RS06420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3V41_RS06425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3V41_RS06445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3V41_RS06455	COG2949	membrane
C3V41_RS06465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3V41_RS06475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3V41_RS06480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3V41_RS06485	COG1053	succinate dehydrogenase
C3V41_RS06510	COG0802	atpase or kinase
C3V41_RS06515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3V41_RS06520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3V41_RS06520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3V41_RS06525	COG0736	holo-[acyl-carrier-protein] synthase activity
C3V41_RS06530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3V41_RS06535	COG1072	(Pantothenic acid kinase))
C3V41_RS06570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3V41_RS06575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3V41_RS06580	COG0101	tRNA pseudouridine synthase activity
C3V41_RS06590	COG1252	NADH dehydrogenase
C3V41_RS06600	COG0203	ribosomal protein L17
C3V41_RS06605	COG0202	RNA polymerase activity
C3V41_RS06610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3V41_RS06615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3V41_RS06620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3V41_RS06625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3V41_RS06645	COG0563	adenylate kinase activity
C3V41_RS06655	COG0200	Binds to the 23S rRNA
C3V41_RS06660	COG1841	ribosomal large subunit assembly
C3V41_RS06665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3V41_RS06670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3V41_RS06675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3V41_RS06685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3V41_RS06690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3V41_RS06695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3V41_RS06700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3V41_RS06705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3V41_RS06710	COG0255	Belongs to the universal ribosomal protein uL29 family
C3V41_RS06715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3V41_RS06720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3V41_RS06725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3V41_RS06730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3V41_RS06735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3V41_RS06740	COG0089	rRNA binding
C3V41_RS06750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3V41_RS06755	COG0051	transcription antitermination factor activity, RNA binding
C3V41_RS06775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3V41_RS06780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3V41_RS06785	COG0049	tRNA binding
C3V41_RS06790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3V41_RS06850	COG1674	ftsk spoiiie
C3V41_RS06890	COG0714	Associated with various cellular activities
C3V41_RS07000	COG4245	von Willebrand factor, type A
C3V41_RS07025	COG2197	response regulator
C3V41_RS07050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3V41_RS07090	COG1674	ftsk spoiiie
C3V41_RS07095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3V41_RS07100	COG0085	RNA polymerase activity
C3V41_RS07105	COG0222	ribosome binding
C3V41_RS07110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3V41_RS07120	COG0081	regulation of translation
C3V41_RS07125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3V41_RS07130	COG0250	Participates in transcription elongation, termination and antitermination
C3V41_RS07145	COG0436	Aminotransferase
C3V41_RS07155	COG2226	methyltransferase
C3V41_RS07160	COG1169	isochorismate synthase
C3V41_RS07165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3V41_RS07170	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3V41_RS07175	COG4948	Mandelate Racemase Muconate Lactonizing
C3V41_RS07180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3V41_RS07185	COG2235	arginine
C3V41_RS07190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C3V41_RS07195	COG3477	response to acidic pH
C3V41_RS07220	COG0406	alpha-ribazole phosphatase activity
C3V41_RS07225	COG2171	N-acyltransferase activity
C3V41_RS07240	COG4115	mRNA cleavage
C3V41_RS07245	COG2161	toxin-antitoxin pair type II binding
C3V41_RS07265	COG1217	gtp-binding protein TYPA
C3V41_RS07300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3V41_RS07305	COG0601	transmembrane transport
C3V41_RS07310	COG4166	transmembrane transport
C3V41_RS07315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V41_RS07340	COG1902	pentaerythritol trinitrate reductase activity
C3V41_RS07345	COG1362	aminopeptidase activity
C3V41_RS07405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3V41_RS07425	COG0542	response to heat
C3V41_RS07545	COG2181	nitrate reductase activity
C3V41_RS07545	COG0247	lactate metabolic process
C3V41_RS07560	COG1132	(ABC) transporter
C3V41_RS07560	COG2375	cellular response to nickel ion
C3V41_RS07585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V41_RS07590	COG1121	(ABC) transporter
C3V41_RS07605	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3V41_RS07615	COG3250	beta-galactosidase activity
C3V41_RS07630	COG1263	PTS System
C3V41_RS07630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V41_RS07630	COG2190	(PTS) system
C3V41_RS07635	COG0542	response to heat
C3V41_RS07660	COG0789	Transcriptional regulator
C3V41_RS07665	COG0484	heat shock protein binding
C3V41_RS07670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3V41_RS07675	COG0443	Heat shock 70 kDa protein
C3V41_RS07685	COG1131	(ABC) transporter
C3V41_RS07695	COG2197	response regulator
C3V41_RS07785	COG3842	ATPase activity
C3V41_RS07810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C3V41_RS07820	COG0596	Alpha beta hydrolase
C3V41_RS07905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3V41_RS07910	COG0789	Transcriptional regulator
C3V41_RS07920	COG1131	(ABC) transporter
C3V41_RS07990	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C3V41_RS08010	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C3V41_RS08020	COG1737	Transcriptional regulator
C3V41_RS08025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V41_RS08030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V41_RS08035	COG1121	(ABC) transporter
C3V41_RS08040	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3V41_RS08045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3V41_RS08065	COG1309	transcriptional regulator
C3V41_RS08070	COG1131	(ABC) transporter
C3V41_RS08110	COG2233	PERMEase
C3V41_RS08125	COG0215	cysteine-tRNA ligase activity
C3V41_RS08130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3V41_RS08160	COG1309	transcriptional regulator
C3V41_RS08185	COG1216	Glycosyl transferase, family 2
C3V41_RS08190	COG0488	(ABC) transporter
C3V41_RS08195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3V41_RS08200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3V41_RS08215	COG0084	hydrolase, TatD family'
C3V41_RS08220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V41_RS08230	COG1335	isochorismatase
C3V41_RS08255	COG0252	asparaginase activity
C3V41_RS08265	COG0470	DNA polymerase III
C3V41_RS08295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3V41_RS08300	COG1329	Transcriptional regulator
C3V41_RS08305	COG0745	RESPONSE REGULATOR receiver
C3V41_RS08310	COG5002	protein histidine kinase activity
C3V41_RS08390	COG0515	serine threonine protein kinase
C3V41_RS08415	COG0714	Associated with various cellular activities
C3V41_RS08425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3V41_RS08425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3V41_RS08515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3V41_RS08520	COG0626	cystathionine gamma-synthase activity
C3V41_RS08555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3V41_RS08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3V41_RS08580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3V41_RS08580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3V41_RS08585	COG0584	glycerophosphoryl diester phosphodiesterase
C3V41_RS08595	COG1404	Belongs to the peptidase S8 family
C3V41_RS08615	COG1653	transport
C3V41_RS08625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3V41_RS08640	COG1203	CRISPR-associated helicase, Cas3
C3V41_RS08685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3V41_RS08700	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C3V41_RS08705	COG1737	Transcriptional regulator
C3V41_RS08720	COG2211	Major facilitator Superfamily
C3V41_RS08735	COG3177	Filamentation induced by cAMP protein fic
C3V41_RS08740	COG0385	Bile acid
C3V41_RS08750	COG3311	Transcriptional regulator
C3V41_RS08770	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C3V41_RS08790	COG3852	Histidine kinase
C3V41_RS08795	COG0471	metal ion transport
C3V41_RS08825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V41_RS08830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V41_RS08835	COG1120	ATPase activity
C3V41_RS08845	COG1854	S-ribosylhomocysteine lyase activity
C3V41_RS08860	COG5002	protein histidine kinase activity
C3V41_RS08865	COG2885	chlorophyll binding
C3V41_RS08875	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C3V41_RS08875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3V41_RS08875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3V41_RS08880	COG1461	Dihydroxyacetone kinase
C3V41_RS08900	COG1309	transcriptional regulator
C3V41_RS08955	COG1674	ftsk spoiiie
C3V41_RS08975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3V41_RS08980	COG1780	Probably involved in ribonucleotide reductase function
C3V41_RS08990	COG1827	regulation of RNA biosynthetic process
C3V41_RS09030	COG1131	(ABC) transporter
C3V41_RS09040	COG2197	response regulator
C3V41_RS09105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3V41_RS09145	COG1653	transport
C3V41_RS09175	COG1950	PFAM Membrane protein of
C3V41_RS09185	COG1937	Protein conserved in bacteria
C3V41_RS09225	COG3833	ABC-type maltose transport systems, permease component
C3V41_RS09230	COG1175	transmembrane transport
C3V41_RS09250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3V41_RS09255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C3V41_RS09270	COG0617	tRNA 3'-terminal CCA addition
C3V41_RS09285	COG0728	peptidoglycan biosynthetic process
C3V41_RS09290	COG0492	ferredoxin-NADP+ reductase activity
C3V41_RS09315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3V41_RS09325	COG0604	alcohol dehydrogenase
C3V41_RS09330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3V41_RS09335	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3V41_RS09350	COG0357	Ribosomal RNA small subunit methyltransferase G
C3V41_RS09360	COG0706	membrane insertase activity
C3V41_RS09365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3V41_RS09370	COG0594	ribonuclease P activity
C3V41_RS09375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3V41_RS09380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3V41_RS09385	COG0592	DNA-directed DNA polymerase activity
C3V41_RS09390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3V41_RS09405	COG4555	ABC transporter
C3V41_RS09420	COG1162	GTPase activity
C3V41_RS09425	COG0187	DNA topoisomerase II activity
C3V41_RS09430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3V41_RS09495	COG3550	peptidyl-serine autophosphorylation
C3V41_RS09505	COG1760	l-serine dehydratase
C3V41_RS09510	COG0351	phosphomethylpyrimidine kinase
C3V41_RS09520	COG1716	ATPase activity
C3V41_RS09525	COG1716	ATPase activity
C3V41_RS09540	COG0768	penicillin binding
C3V41_RS09550	COG0515	serine threonine protein kinase
C3V41_RS09555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3V41_RS09560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3V41_RS09570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3V41_RS09570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3V41_RS09575	COG1940	carbohydrate kinase activity
C3V41_RS09630	COG3764	Sortase (surface protein transpeptidase)
C3V41_RS09640	COG1063	alcohol dehydrogenase
C3V41_RS09660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3V41_RS09680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3V41_RS09685	COG0360	Binds together with S18 to 16S ribosomal RNA
C3V41_RS09695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3V41_RS09700	COG0359	binds to the 23S rRNA
C3V41_RS09720	COG0534	Mate efflux family protein
C3V41_RS09725	COG0305	Participates in initiation and elongation during chromosome replication
C3V41_RS09795	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
C3V41_RS09800	COG2890	protein-(glutamine-N5) methyltransferase activity
C3V41_RS09830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3V41_RS09845	COG0037	tRNA processing
C3V41_RS09845	COG0590	tRNA wobble adenosine to inosine editing
C3V41_RS09855	COG0577	efflux transmembrane transporter activity
C3V41_RS09855	COG1136	(ABC) transporter
C3V41_RS09880	COG1136	(ABC) transporter
C3V41_RS09880	COG4591	ABC-type transport system involved in lipoprotein release permease component
C3V41_RS09885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3V41_RS09890	COG1643	Atp-dependent helicase
C3V41_RS09975	COG0464	growth
C3V41_RS09985	COG1309	transcriptional regulator
C3V41_RS09990	COG2814	Major facilitator Superfamily
C3V41_RS10005	COG0702	epimerase
C3V41_RS10025	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C3V41_RS10035	COG0569	domain protein
C3V41_RS10035	COG2985	domain, Protein
C3V41_RS10040	COG1595	DNA-templated transcription, initiation
C3V41_RS10060	COG1131	(ABC) transporter
C3V41_RS10075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3V41_RS10095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3V41_RS10120	COG2089	acid synthase
C3V41_RS10125	COG1083	cytidylyl-transferase
C3V41_RS10140	COG1216	Glycosyl transferase, family 2
C3V41_RS10140	COG0438	transferase activity, transferring glycosyl groups
C3V41_RS10155	COG1132	(ABC) transporter
C3V41_RS10180	COG1754	DNA topoisomerase type I activity
C3V41_RS10180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3V41_RS10240	COG1970	mechanosensitive ion channel activity
C3V41_RS10250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3V41_RS10270	COG2205	protein histidine kinase activity
C3V41_RS10275	COG0745	RESPONSE REGULATOR receiver
C3V41_RS10290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3V41_RS10305	COG0459	protein refolding
C3V41_RS10320	COG2205	protein histidine kinase activity
C3V41_RS10325	COG0745	RESPONSE REGULATOR receiver
C3V41_RS10335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3V41_RS10335	COG0519	Catalyzes the synthesis of GMP from XMP
C3V41_RS10350	COG1842	Phage shock protein A
C3V41_RS10370	COG1061	Type III restriction enzyme res subunit
C3V41_RS10385	COG2252	PERMEase
C3V41_RS10415	COG0588	phosphoglycerate mutase activity
C3V41_RS10420	COG0148	phosphopyruvate hydratase activity
C3V41_RS10480	COG0489	protein tyrosine kinase activity
C3V41_RS10490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3V41_RS10495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3V41_RS10500	COG0193	aminoacyl-tRNA hydrolase activity
C3V41_RS10505	COG2197	response regulator
C3V41_RS10540	COG0129	dihydroxy-acid dehydratase activity
C3V41_RS10550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3V41_RS10575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3V41_RS10580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3V41_RS10595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3V41_RS10600	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3V41_RS10610	COG1722	exodeoxyribonuclease VII activity
C3V41_RS10615	COG1570	exodeoxyribonuclease VII activity
C3V41_RS10625	COG0515	serine threonine protein kinase
C3V41_RS10760	COG0433	COG0433 Predicted ATPase
C3V41_RS10760	COG1674	ftsk spoiiie
C3V41_RS10870	COG3842	ATPase activity
C3V41_RS10885	COG0326	Molecular chaperone. Has ATPase activity
C3V41_RS10895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3V41_RS10915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3V41_RS10920	COG1643	Atp-dependent helicase
C3V41_RS10920	COG1643	Atp-dependent helicase
C3V41_RS10930	COG0698	ribose 5-phosphate isomerase
C3V41_RS10935	COG0515	serine threonine protein kinase
C3V41_RS10995	COG0572	uridine kinase
C3V41_RS11015	COG2375	cellular response to nickel ion
C3V41_RS11015	COG1132	(ABC) transporter
C3V41_RS11020	COG1132	(ABC) transporter
C3V41_RS11045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3V41_RS11050	COG2860	membrane
C3V41_RS11105	COG0714	Associated with various cellular activities
C3V41_RS11140	COG0494	nUDIX hydrolase
C3V41_RS11175	COG2176	DNA-directed DNA polymerase activity
C3V41_RS11215	COG0778	Nitroreductase
C3V41_RS11240	COG0395	ABC-type sugar transport system, permease component
C3V41_RS11245	COG0300	oxidoreductase activity
C3V41_RS11255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3V41_RS11270	COG0191	fructose-bisphosphate aldolase activity
C3V41_RS11280	COG2201	protein-glutamate methylesterase activity
C3V41_RS11315	COG1136	(ABC) transporter
C3V41_RS11315	COG0577	efflux transmembrane transporter activity
C3V41_RS11370	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3V41_RS11380	COG0151	Belongs to the GarS family
C3V41_RS11395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3V41_RS11430	COG0047	phosphoribosylformylglycinamidine synthase activity
C3V41_RS11440	COG0438	transferase activity, transferring glycosyl groups
C3V41_RS11455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3V41_RS11470	COG2814	Major facilitator Superfamily
C3V41_RS11515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3V41_RS11520	COG1349	DNA-binding transcription factor activity
C3V41_RS11530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3V41_RS11530	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C3V41_RS11530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3V41_RS11550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3V41_RS11575	COG1132	(ABC) transporter
C3V41_RS11620	COG0513	Belongs to the DEAD box helicase family
C3V41_RS11695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3V41_RS11710	COG2873	o-acetylhomoserine
C3V41_RS11715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3V41_RS11725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3V41_RS11820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3V41_RS11825	COG0302	gtp cyclohydrolase
C3V41_RS11870	COG2197	response regulator
C3V41_RS11875	COG1136	(ABC) transporter
C3V41_RS11875	COG0577	efflux transmembrane transporter activity
C3V41_RS11880	COG1136	(ABC) transporter
C3V41_RS11880	COG0577	efflux transmembrane transporter activity
C3V41_RS11885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3V41_RS11890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3V41_RS11920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3V41_RS11950	COG3104	oligopeptide transport
C3V41_RS11960	COG1556	Lactate utilization protein
C3V41_RS11965	COG1139	Iron-sulfur cluster binding protein
C3V41_RS11970	COG0247	lactate metabolic process
C3V41_RS11975	COG2205	protein histidine kinase activity
C3V41_RS11980	COG0745	RESPONSE REGULATOR receiver
C3V41_RS11995	COG1136	(ABC) transporter
C3V41_RS12000	COG0577	efflux transmembrane transporter activity
C3V41_RS12005	COG1620	l-lactate permease
C3V41_RS12010	COG2095	MarC family integral membrane protein
C3V41_RS12015	COG2095	MarC family integral membrane protein
C3V41_RS12020	COG0644	oxidoreductase
C3V41_RS12030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3V41_RS12035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3V41_RS12040	COG0649	NAD binding
C3V41_RS12050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3V41_RS12055	COG1034	ATP synthesis coupled electron transport
C3V41_RS12060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3V41_RS12065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3V41_RS12075	COG0713	ATP synthesis coupled electron transport
C3V41_RS12080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3V41_RS12090	COG1007	ATP synthesis coupled electron transport
C3V41_RS12095	COG0142	geranyltranstransferase activity
C3V41_RS12100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3V41_RS12105	COG1518	maintenance of DNA repeat elements
C3V41_RS12120	COG1857	crispr-associated protein
C3V41_RS12160	COG3480	Lon protease (S16) C-terminal proteolytic domain
C3V41_RS12180	COG1611	Belongs to the LOG family
C3V41_RS12185	COG1615	UPF0182 protein
C3V41_RS12190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3V41_RS12195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V41_RS12200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V41_RS12200	COG1321	iron dependent repressor
C3V41_RS12210	COG1121	(ABC) transporter
C3V41_RS12215	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3V41_RS12220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3V41_RS12230	COG4221	oxidoreductase activity
C3V41_RS12245	COG1136	(ABC) transporter
C3V41_RS12250	COG0577	efflux transmembrane transporter activity
C3V41_RS12275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3V41_RS12290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3V41_RS12300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3V41_RS12305	COG0494	nUDIX hydrolase
C3V41_RS12305	COG0406	alpha-ribazole phosphatase activity
C3V41_RS12330	COG0745	RESPONSE REGULATOR receiver
C3V41_RS12345	COG4152	abc transporter atp-binding protein
C3V41_RS12350	COG1196	nuclear chromosome segregation
C3V41_RS12380	COG2197	response regulator
C3V41_RS12385	COG4585	Histidine kinase
C3V41_RS12390	COG0842	Transport permease protein
C3V41_RS12395	COG1131	(ABC) transporter
C3V41_RS12405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3V41_RS12415	COG0366	Alpha amylase catalytic
C3V41_RS12420	COG1132	(ABC) transporter
C3V41_RS12425	COG1132	(ABC) transporter
C3V41_RS12435	COG0180	Tryptophanyl-tRNA synthetase
C3V41_RS12455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3V41_RS12460	COG0714	Associated with various cellular activities
C3V41_RS12470	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C3V41_RS12490	COG3831	ATPase activity
C3V41_RS12495	COG3831	ATPase activity
C3V41_RS12505	COG0482	sulfurtransferase activity
C3V41_RS12520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3V41_RS12550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3V41_RS12580	COG1490	D-aminoacyl-tRNA deacylase activity
C3V41_RS12585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C3V41_RS12595	COG1695	Transcriptional regulator
C3V41_RS12605	COG0542	response to heat
C3V41_RS12640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3V41_RS12655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3V41_RS12655	COG0574	Belongs to the PEP-utilizing enzyme family
C3V41_RS12675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP