locus-tag	class	description
B6G06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6G06_RS00010	COG0592	DNA-directed DNA polymerase activity
B6G06_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6G06_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B6G06_RS00025	COG0187	DNA topoisomerase II activity
B6G06_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6G06_RS00070	COG3764	Sortase (surface protein transpeptidase)
B6G06_RS00080	COG0515	serine threonine protein kinase
B6G06_RS00085	COG0768	penicillin binding
B6G06_RS00100	COG1716	ATPase activity
B6G06_RS00105	COG1716	ATPase activity
B6G06_RS00125	COG1966	Carbon starvation protein
B6G06_RS00135	COG2855	membrane
B6G06_RS00140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6G06_RS00165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6G06_RS00195	COG3842	ATPase activity
B6G06_RS00200	COG1178	ABC-type Fe3 transport system permease component
B6G06_RS00205	COG1840	ABC-type Fe3 transport system, periplasmic component
B6G06_RS00210	COG0745	RESPONSE REGULATOR receiver
B6G06_RS00250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6G06_RS00255	COG0561	phosphatase activity
B6G06_RS00295	COG0626	cystathionine gamma-synthase activity
B6G06_RS00330	COG2197	response regulator
B6G06_RS00340	COG1131	(ABC) transporter
B6G06_RS00355	COG2181	nitrate reductase activity
B6G06_RS00355	COG0247	lactate metabolic process
B6G06_RS00375	COG3842	ATPase activity
B6G06_RS00430	COG0475	glutathione-regulated potassium exporter activity
B6G06_RS00465	COG1609	Transcriptional regulator
B6G06_RS00475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6G06_RS00495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B6G06_RS00505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6G06_RS00515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6G06_RS00530	COG2011	ABC-type metal ion transport system permease component
B6G06_RS00535	COG1464	Belongs to the NlpA lipoprotein family
B6G06_RS00540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6G06_RS00545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B6G06_RS00555	COG0110	maltose O-acetyltransferase activity
B6G06_RS00565	COG1643	Atp-dependent helicase
B6G06_RS00585	COG2233	PERMEase
B6G06_RS00600	COG0443	Heat shock 70 kDa protein
B6G06_RS00605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6G06_RS00610	COG0484	heat shock protein binding
B6G06_RS00615	COG0789	Transcriptional regulator
B6G06_RS00650	COG2205	protein histidine kinase activity
B6G06_RS00655	COG0745	RESPONSE REGULATOR receiver
B6G06_RS00665	COG5640	endopeptidase activity
B6G06_RS00675	COG0546	phosphoglycolate phosphatase activity
B6G06_RS00680	COG1609	Transcriptional regulator
B6G06_RS00690	COG1621	beta-fructofuranosidase activity
B6G06_RS00700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6G06_RS00700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6G06_RS00705	COG3715	PTS system
B6G06_RS00710	COG3716	PTS system mannose fructose sorbose family IID component
B6G06_RS00735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B6G06_RS00740	COG0215	cysteine-tRNA ligase activity
B6G06_RS00760	COG3842	ATPase activity
B6G06_RS00780	COG4214	carbohydrate transport
B6G06_RS00790	COG2890	protein-(glutamine-N5) methyltransferase activity
B6G06_RS00800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6G06_RS00815	COG0459	protein refolding
B6G06_RS00830	COG2205	protein histidine kinase activity
B6G06_RS00835	COG0745	RESPONSE REGULATOR receiver
B6G06_RS00845	COG1842	Phage shock protein A
B6G06_RS00855	COG1061	Type III restriction enzyme res subunit
B6G06_RS00875	COG0535	radical SAM domain protein
B6G06_RS00885	COG2252	PERMEase
B6G06_RS00905	COG0791	NLP P60 protein
B6G06_RS00905	COG1388	LysM domain
B6G06_RS00905	COG3103	Sh3 type 3 domain protein
B6G06_RS00930	COG1970	mechanosensitive ion channel activity
B6G06_RS00940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6G06_RS00990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6G06_RS00995	COG0084	hydrolase, TatD family'
B6G06_RS01015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6G06_RS01020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6G06_RS01025	COG0488	(ABC) transporter
B6G06_RS01035	COG2815	serine threonine protein kinase
B6G06_RS01035	COG0515	serine threonine protein kinase
B6G06_RS01065	COG1309	transcriptional regulator
B6G06_RS01080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B6G06_RS01080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6G06_RS01150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6G06_RS01185	COG0148	phosphopyruvate hydratase activity
B6G06_RS01205	COG0710	3-dehydroquinate dehydratase activity
B6G06_RS01215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B6G06_RS01220	COG0193	aminoacyl-tRNA hydrolase activity
B6G06_RS01225	COG2197	response regulator
B6G06_RS01240	COG1131	(ABC) transporter
B6G06_RS01250	COG0545	Peptidyl-prolyl cis-trans isomerase
B6G06_RS01265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6G06_RS01275	COG0431	NADPH-dependent FMN reductase
B6G06_RS01280	COG0431	NADPH-dependent FMN reductase
B6G06_RS01295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6G06_RS01300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6G06_RS01310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6G06_RS01320	COG1722	exodeoxyribonuclease VII activity
B6G06_RS01325	COG1570	exodeoxyribonuclease VII activity
B6G06_RS01330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B6G06_RS01345	COG0012	GTP binding
B6G06_RS01405	COG1362	aminopeptidase activity
B6G06_RS01410	COG3012	SEC-C Motif Domain Protein
B6G06_RS01415	COG1902	pentaerythritol trinitrate reductase activity
B6G06_RS01430	COG4166	transmembrane transport
B6G06_RS01435	COG0601	transmembrane transport
B6G06_RS01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6G06_RS01450	COG1268	BioY protein
B6G06_RS01455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6G06_RS01465	COG1217	gtp-binding protein TYPA
B6G06_RS01500	COG0406	alpha-ribazole phosphatase activity
B6G06_RS01520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B6G06_RS01525	COG2873	o-acetylhomoserine
B6G06_RS01530	COG0791	NLP P60 protein
B6G06_RS01535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B6G06_RS01555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6G06_RS01560	COG0302	gtp cyclohydrolase
B6G06_RS01565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B6G06_RS01570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B6G06_RS01595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B6G06_RS01600	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B6G06_RS01610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6G06_RS01630	COG2814	Major facilitator Superfamily
B6G06_RS01640	COG1556	Lactate utilization protein
B6G06_RS01645	COG1139	Iron-sulfur cluster binding protein
B6G06_RS01650	COG0247	lactate metabolic process
B6G06_RS01655	COG1620	l-lactate permease
B6G06_RS01670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6G06_RS01675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6G06_RS01680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6G06_RS01685	COG2390	Transcriptional regulator
B6G06_RS01695	COG0698	ribose 5-phosphate isomerase
B6G06_RS01705	COG0647	UMP catabolic process
B6G06_RS01710	COG1070	Carbohydrate kinase
B6G06_RS01725	COG2390	Transcriptional regulator
B6G06_RS01730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B6G06_RS01750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B6G06_RS01790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B6G06_RS01805	COG2814	Major facilitator Superfamily
B6G06_RS01815	COG1070	Carbohydrate kinase
B6G06_RS01820	COG2376	Dihydroxyacetone kinase
B6G06_RS01825	COG1461	Dihydroxyacetone kinase
B6G06_RS01830	COG2017	converts alpha-aldose to the beta-anomer
B6G06_RS01840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6G06_RS01855	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6G06_RS01860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6G06_RS01870	COG0436	Aminotransferase
B6G06_RS01895	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6G06_RS01900	COG0250	Participates in transcription elongation, termination and antitermination
B6G06_RS01905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6G06_RS01910	COG0081	regulation of translation
B6G06_RS01935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6G06_RS01940	COG0222	ribosome binding
B6G06_RS01945	COG2838	Isocitrate dehydrogenase
B6G06_RS01960	COG1695	Transcriptional regulator
B6G06_RS01965	COG1595	DNA-templated transcription, initiation
B6G06_RS01970	COG5662	AntiSigma factor
B6G06_RS01980	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6G06_RS01980	COG0567	Dehydrogenase, E1 component
B6G06_RS01985	COG1253	flavin adenine dinucleotide binding
B6G06_RS02055	COG0018	arginyl-trna synthetase
B6G06_RS02060	COG0019	diaminopimelate decarboxylase activity
B6G06_RS02065	COG0460	homoserine dehydrogenase
B6G06_RS02070	COG0083	homoserine kinase activity
B6G06_RS02085	COG0254	rRNA binding
B6G06_RS02090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6G06_RS02155	COG0366	Alpha amylase catalytic
B6G06_RS02160	COG0205	6-phosphofructokinase activity
B6G06_RS02165	COG0045	succinate-CoA ligase (ADP-forming) activity
B6G06_RS02185	COG1946	Acyl-CoA thioesterase
B6G06_RS02190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6G06_RS02195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6G06_RS02205	COG2190	(PTS) system
B6G06_RS02210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6G06_RS02215	COG2188	Transcriptional regulator
B6G06_RS02235	COG3590	peptidase
B6G06_RS02240	COG0698	ribose 5-phosphate isomerase
B6G06_RS02245	COG1929	Belongs to the glycerate kinase type-1 family
B6G06_RS02255	COG1045	serine acetyltransferase
B6G06_RS02260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6G06_RS02265	COG1739	Uncharacterized protein family UPF0029
B6G06_RS02315	COG1201	RNA secondary structure unwinding
B6G06_RS02360	COG0544	peptidyl-prolyl cis-trans isomerase activity
B6G06_RS02380	COG0740	serine-type endopeptidase activity
B6G06_RS02395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B6G06_RS02400	COG0287	Prephenate dehydrogenase
B6G06_RS02400	COG1605	Chorismate mutase
B6G06_RS02420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6G06_RS02425	COG4221	oxidoreductase activity
B6G06_RS02435	COG0730	response to heat
B6G06_RS02440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6G06_RS02440	COG1648	precorrin-2 dehydrogenase activity
B6G06_RS02455	COG0175	sulfate reduction
B6G06_RS02460	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6G06_RS02465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6G06_RS02470	COG1215	transferase activity, transferring glycosyl groups
B6G06_RS02480	COG0438	transferase activity, transferring glycosyl groups
B6G06_RS02490	COG0110	maltose O-acetyltransferase activity
B6G06_RS02500	COG0489	protein tyrosine kinase activity
B6G06_RS02505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6G06_RS02510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6G06_RS02515	COG0285	dihydrofolate synthase activity
B6G06_RS02520	COG0105	UTP biosynthetic process
B6G06_RS02530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6G06_RS02535	COG0154	amidase activity
B6G06_RS02540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6G06_RS02570	COG1175	transmembrane transport
B6G06_RS02575	COG0395	ABC-type sugar transport system, permease component
B6G06_RS02580	COG1621	beta-fructofuranosidase activity
B6G06_RS02580	COG3583	domain protein
B6G06_RS02580	COG5492	domain, Protein
B6G06_RS02585	COG1609	Transcriptional regulator
B6G06_RS02590	COG2966	Psort location CytoplasmicMembrane, score
B6G06_RS02595	COG2985	domain, Protein
B6G06_RS02595	COG0569	domain protein
B6G06_RS02610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6G06_RS02620	COG0473	3-isopropylmalate dehydrogenase activity
B6G06_RS02625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6G06_RS02630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6G06_RS02630	COG0463	Glycosyl transferase, family 2
B6G06_RS02635	COG1316	TRANSCRIPTIONal
B6G06_RS02640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B6G06_RS02645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6G06_RS02650	COG1216	Glycosyl transferase, family 2
B6G06_RS02695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6G06_RS02700	COG1086	Polysaccharide biosynthesis protein
B6G06_RS02705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6G06_RS02720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B6G06_RS02735	COG1121	(ABC) transporter
B6G06_RS02745	COG0629	single-stranded DNA binding
B6G06_RS02755	COG2884	Cell division ATP-binding protein ftsE
B6G06_RS02760	COG2177	Part of the ABC transporter FtsEX involved in
B6G06_RS02780	COG2188	Transcriptional regulator
B6G06_RS02785	COG4166	transmembrane transport
B6G06_RS02795	COG0444	Belongs to the ABC transporter superfamily
B6G06_RS02800	COG4608	Belongs to the ABC transporter superfamily
B6G06_RS02815	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
B6G06_RS02825	COG0363	glucosamine-6-phosphate deaminase activity
B6G06_RS02845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B6G06_RS02855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6G06_RS02860	COG1234	tRNA 3'-trailer cleavage
B6G06_RS02870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6G06_RS02875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6G06_RS02915	COG3304	Inner membrane component domain
B6G06_RS02920	COG0833	amino acid
B6G06_RS02925	COG2040	homocysteine
B6G06_RS02935	COG2272	Belongs to the type-B carboxylesterase lipase family
B6G06_RS02950	COG1115	amino acid carrier protein
B6G06_RS02955	COG1115	amino acid carrier protein
B6G06_RS02960	COG1115	amino acid carrier protein
B6G06_RS02965	COG1115	amino acid carrier protein
B6G06_RS02970	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6G06_RS02980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6G06_RS03010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B6G06_RS03020	COG1674	ftsk spoiiie
B6G06_RS03030	COG1058	Belongs to the CinA family
B6G06_RS03030	COG1546	Belongs to the CinA family
B6G06_RS03035	COG1396	sequence-specific DNA binding
B6G06_RS03045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B6G06_RS03050	COG2137	regulation of response to DNA damage stimulus
B6G06_RS03055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6G06_RS03065	COG0395	ABC-type sugar transport system, permease component
B6G06_RS03070	COG1175	transmembrane transport
B6G06_RS03080	COG1940	carbohydrate kinase activity
B6G06_RS03080	COG1846	Transcriptional regulator
B6G06_RS03085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6G06_RS03115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B6G06_RS03120	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B6G06_RS03125	COG1114	Component of the transport system for branched-chain amino acids
B6G06_RS03130	COG2813	Specifically methylates the guanine in position
B6G06_RS03140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6G06_RS03155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6G06_RS03165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6G06_RS03190	COG0066	3-isopropylmalate dehydratase activity
B6G06_RS03195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6G06_RS03205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6G06_RS03220	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6G06_RS03230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6G06_RS03235	COG1461	Dihydroxyacetone kinase
B6G06_RS03260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6G06_RS03275	COG0571	ribonuclease III activity
B6G06_RS03280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6G06_RS03295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B6G06_RS03300	COG4988	ABC transporter
B6G06_RS03305	COG1294	oxidase, subunit
B6G06_RS03310	COG1271	oxidase subunit
B6G06_RS03315	COG1530	ribonuclease E activity
B6G06_RS03320	COG3005	denitrification pathway
B6G06_RS03335	COG0785	Cytochrome C biogenesis protein
B6G06_RS03340	COG1333	cytochrome c biogenesis protein
B6G06_RS03345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6G06_RS03350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6G06_RS03355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B6G06_RS03360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B6G06_RS03365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6G06_RS03370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B6G06_RS03380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B6G06_RS03385	COG1349	DNA-binding transcription factor activity
B6G06_RS03390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6G06_RS03400	COG0799	negative regulation of ribosome biogenesis
B6G06_RS03430	COG0733	neurotransmitter:sodium symporter activity
B6G06_RS03455	COG0537	adenosine 5'-monophosphoramidase activity
B6G06_RS03460	COG0495	leucyl-tRNA aminoacylation
B6G06_RS03465	COG0433	COG0433 Predicted ATPase
B6G06_RS03470	COG1307	EDD domain protein, DegV family
B6G06_RS03485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6G06_RS03510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B6G06_RS03515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6G06_RS03520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6G06_RS03525	COG1126	abc transporter atp-binding protein
B6G06_RS03530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6G06_RS03535	COG0765	amino acid transport
B6G06_RS03540	COG0765	amino acid transport
B6G06_RS03555	COG0072	phenylalanine-tRNA ligase activity
B6G06_RS03555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6G06_RS03565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6G06_RS03575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6G06_RS03580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6G06_RS03585	COG1438	arginine binding
B6G06_RS03590	COG0137	argininosuccinate synthase activity
B6G06_RS03600	COG0165	Argininosuccinate lyase
B6G06_RS03605	COG2094	Belongs to the DNA glycosylase MPG family
B6G06_RS03615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6G06_RS03640	COG0647	UMP catabolic process
B6G06_RS03655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6G06_RS03660	COG0497	DNA recombination
B6G06_RS03690	COG0483	inositol monophosphate 1-phosphatase activity
B6G06_RS03705	COG0719	Fe-S assembly protein
B6G06_RS03715	COG0396	ATPase activity
B6G06_RS03725	COG0822	iron-sulfur transferase activity
B6G06_RS03730	COG2151	metal-sulfur cluster biosynthetic enzyme
B6G06_RS03745	COG0167	dihydroorotate dehydrogenase activity
B6G06_RS03750	COG0667	Aldo Keto reductase
B6G06_RS03765	COG1929	Belongs to the glycerate kinase type-1 family
B6G06_RS03785	COG0358	DNA primase activity
B6G06_RS03835	COG1027	Aspartate ammonia-lyase
B6G06_RS03840	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B6G06_RS03880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6G06_RS03890	COG3022	response to hydroperoxide
B6G06_RS03915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B6G06_RS03920	COG0174	glutamine synthetase
B6G06_RS03925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B6G06_RS03940	COG0765	amino acid transport
B6G06_RS03960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B6G06_RS03965	COG0321	lipoyl(octanoyl) transferase activity
B6G06_RS03975	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6G06_RS03980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6G06_RS03985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6G06_RS04005	COG1882	Formate acetyltransferase
B6G06_RS04060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6G06_RS04070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6G06_RS04080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6G06_RS04085	COG1560	Kdo2-lipid A biosynthetic process
B6G06_RS04090	COG0438	transferase activity, transferring glycosyl groups
B6G06_RS04105	COG0494	nUDIX hydrolase
B6G06_RS04110	COG0217	transcriptional regulatory protein
B6G06_RS04115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B6G06_RS04120	COG0632	four-way junction helicase activity
B6G06_RS04125	COG2255	four-way junction helicase activity
B6G06_RS04135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6G06_RS04140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6G06_RS04145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6G06_RS04150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6G06_RS04160	COG1196	nuclear chromosome segregation
B6G06_RS04180	COG0124	histidyl-tRNA synthetase
B6G06_RS04210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B6G06_RS04220	COG0640	Transcriptional regulator
B6G06_RS04225	COG0009	L-threonylcarbamoyladenylate synthase
B6G06_RS04230	COG2409	Drug exporters of the RND superfamily
B6G06_RS04245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6G06_RS04255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6G06_RS04265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6G06_RS04270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6G06_RS04290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6G06_RS04295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6G06_RS04305	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B6G06_RS04310	COG0540	Belongs to the ATCase OTCase family
B6G06_RS04315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6G06_RS04325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6G06_RS04330	COG0284	orotidine-5'-phosphate decarboxylase activity
B6G06_RS04340	COG0194	GDP metabolic process
B6G06_RS04345	COG1758	RNA polymerase activity
B6G06_RS04355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B6G06_RS04375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6G06_RS04385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6G06_RS04400	COG4770	biotin carboxylase activity
B6G06_RS04405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6G06_RS04410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6G06_RS04415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B6G06_RS04425	COG1335	isochorismatase
B6G06_RS04435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6G06_RS04440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B6G06_RS04445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6G06_RS04450	COG0140	phosphoribosyl-ATP diphosphatase activity
B6G06_RS04475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6G06_RS04480	COG0805	protein transport
B6G06_RS04495	COG1216	Glycosyl transferase, family 2
B6G06_RS04500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6G06_RS04520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6G06_RS04535	COG1609	Transcriptional regulator
B6G06_RS04540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6G06_RS04540	COG1263	PTS System
B6G06_RS04540	COG2190	(PTS) system
B6G06_RS04545	COG0443	Heat shock 70 kDa protein
B6G06_RS04565	COG1716	ATPase activity
B6G06_RS04570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B6G06_RS04590	COG4989	oxidoreductase activity
B6G06_RS04655	COG0166	Belongs to the GPI family
B6G06_RS04660	COG1160	GTP binding
B6G06_RS04675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6G06_RS04680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6G06_RS04695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6G06_RS04700	COG0149	triose-phosphate isomerase activity
B6G06_RS04705	COG0126	phosphoglycerate kinase activity
B6G06_RS04710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B6G06_RS04715	COG1481	regulation of sporulation
B6G06_RS04725	COG1660	Displays ATPase and GTPase activities
B6G06_RS04735	COG3711	transcriptional antiterminator
B6G06_RS04745	COG1263	PTS System
B6G06_RS04745	COG2190	(PTS) system
B6G06_RS04745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6G06_RS04755	COG0322	excinuclease ABC activity
B6G06_RS04785	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B6G06_RS04790	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B6G06_RS04795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6G06_RS04835	COG0556	nucleotide-excision repair
B6G06_RS04840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B6G06_RS04840	COG0237	dephospho-CoA kinase activity
B6G06_RS04850	COG0539	negative regulation of cytoplasmic translation
B6G06_RS04860	COG2050	protein possibly involved in aromatic compounds catabolism
B6G06_RS04880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6G06_RS04885	COG0134	indole-3-glycerol-phosphate synthase activity
B6G06_RS04890	COG1297	OPT oligopeptide transporter protein
B6G06_RS04910	COG0107	imidazoleglycerol-phosphate synthase activity
B6G06_RS04920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6G06_RS04930	COG4122	O-methyltransferase activity
B6G06_RS04935	COG1222	aaa ATPase
B6G06_RS04945	COG2814	Major facilitator Superfamily
B6G06_RS04950	COG1994	Peptidase M50
B6G06_RS04950	COG0517	IMP dehydrogenase activity
B6G06_RS04960	COG2391	methyltransferase activity
B6G06_RS04970	COG0667	Aldo Keto reductase
B6G06_RS04980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6G06_RS05005	COG0676	glucose-6-phosphate 1-epimerase activity
B6G06_RS05015	COG0587	DNA-directed DNA polymerase activity
B6G06_RS05020	COG0833	amino acid
B6G06_RS05040	COG1881	PFAM PEBP family protein
B6G06_RS05045	COG4221	oxidoreductase activity
B6G06_RS05050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B6G06_RS05055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6G06_RS05060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6G06_RS05065	COG0531	amino acid
B6G06_RS05070	COG0569	domain protein
B6G06_RS05110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6G06_RS05120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6G06_RS05135	COG0187	DNA topoisomerase II activity
B6G06_RS05150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6G06_RS05155	COG0142	geranyltranstransferase activity
B6G06_RS05160	COG0515	serine threonine protein kinase
B6G06_RS05160	COG2815	serine threonine protein kinase
B6G06_RS05170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B6G06_RS05215	COG0488	(ABC) transporter
B6G06_RS05240	COG1119	ATPase activity
B6G06_RS05250	COG0297	glycogen (starch) synthase activity
B6G06_RS05260	COG0560	Phosphoserine phosphatase
B6G06_RS05290	COG0423	glycine-tRNA ligase activity
B6G06_RS05305	COG0519	Catalyzes the synthesis of GMP from XMP
B6G06_RS05305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6G06_RS05310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6G06_RS05315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6G06_RS05320	COG1381	Involved in DNA repair and RecF pathway recombination
B6G06_RS05325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6G06_RS05345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6G06_RS05350	COG1702	phosphate starvation-inducible protein PhoH
B6G06_RS05370	COG1309	transcriptional regulator
B6G06_RS05375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B6G06_RS05385	COG0484	heat shock protein binding
B6G06_RS05390	COG1420	regulation of RNA biosynthetic process
B6G06_RS05400	COG2271	Major facilitator Superfamily
B6G06_RS05410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6G06_RS05430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6G06_RS05440	COG0481	GTPase activity
B6G06_RS05450	COG0133	tryptophan synthase activity
B6G06_RS05455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6G06_RS05460	COG0512	Glutamine amidotransferase of anthranilate synthase
B6G06_RS05465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6G06_RS05475	COG0159	tryptophan synthase activity
B6G06_RS05490	COG0268	Binds directly to 16S ribosomal RNA
B6G06_RS05495	COG4868	Belongs to the UPF0371 family
B6G06_RS05515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6G06_RS05520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6G06_RS05530	COG0131	Imidazoleglycerol-phosphate dehydratase
B6G06_RS05535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6G06_RS05540	COG0025	NhaP-type Na H and K H
B6G06_RS05565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B6G06_RS05585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6G06_RS05605	COG2501	S4 domain
B6G06_RS05610	COG0587	DNA-directed DNA polymerase activity
B6G06_RS05625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6G06_RS05640	COG1799	cell septum assembly
B6G06_RS05645	COG1496	oxidoreductase activity
B6G06_RS05650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B6G06_RS05660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6G06_RS05665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6G06_RS05670	COG0772	Belongs to the SEDS family
B6G06_RS05675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B6G06_RS05680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6G06_RS05685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6G06_RS05690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6G06_RS05695	COG0768	penicillin binding
B6G06_RS05705	COG0275	rRNA processing
B6G06_RS05710	COG2001	Belongs to the MraZ family
B6G06_RS05720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6G06_RS05740	COG0318	PFAM AMP-dependent synthetase and ligase
B6G06_RS05750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6G06_RS05765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6G06_RS05770	COG0612	Peptidase, M16
B6G06_RS05775	COG1185	polyribonucleotide nucleotidyltransferase activity
B6G06_RS05800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6G06_RS05805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6G06_RS05820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6G06_RS05835	COG0779	Required for maturation of 30S ribosomal subunits
B6G06_RS05845	COG0442	prolyl-tRNA aminoacylation
B6G06_RS05855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B6G06_RS05860	COG0750	zinc metalloprotease
B6G06_RS05865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B6G06_RS05875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B6G06_RS05885	COG0233	cytoplasmic translational termination
B6G06_RS05905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B6G06_RS05910	COG0052	Belongs to the universal ribosomal protein uS2 family
B6G06_RS05935	COG0792	nuclease activity
B6G06_RS05945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6G06_RS05960	COG0681	Belongs to the peptidase S26 family
B6G06_RS05970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6G06_RS05985	COG0667	Aldo Keto reductase
B6G06_RS05990	COG1837	Belongs to the UPF0109 family
B6G06_RS05995	COG0228	four-way junction DNA binding
B6G06_RS06000	COG1115	amino acid carrier protein
B6G06_RS06005	COG1131	(ABC) transporter
B6G06_RS06015	COG4585	Histidine kinase
B6G06_RS06020	COG2197	response regulator
B6G06_RS06030	COG0789	Transcriptional regulator
B6G06_RS06040	COG1196	nuclear chromosome segregation
B6G06_RS06045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6G06_RS06080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B6G06_RS06085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B6G06_RS06095	COG2814	Major facilitator Superfamily
B6G06_RS06105	COG0673	inositol 2-dehydrogenase activity
B6G06_RS06110	COG1609	Transcriptional regulator
B6G06_RS06130	COG1125	glycine betaine transport
B6G06_RS06130	COG0517	IMP dehydrogenase activity
B6G06_RS06135	COG3321	synthase
B6G06_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
B6G06_RS06135	COG0604	alcohol dehydrogenase
B6G06_RS06145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B6G06_RS06150	COG0114	fumarate hydratase activity
B6G06_RS06160	COG1615	UPF0182 protein
B6G06_RS06215	COG1857	crispr-associated protein
B6G06_RS06230	COG1518	maintenance of DNA repeat elements
B6G06_RS06245	COG0482	sulfurtransferase activity
B6G06_RS06250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6G06_RS06265	COG0180	Tryptophanyl-tRNA synthetase
B6G06_RS06270	COG0366	Alpha amylase catalytic
B6G06_RS06285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B6G06_RS06290	COG0058	SHG alpha-glucan phosphorylase activity
B6G06_RS06315	COG1725	Transcriptional regulator
B6G06_RS06330	COG0039	L-malate dehydrogenase activity
B6G06_RS06340	COG1132	(ABC) transporter
B6G06_RS06360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B6G06_RS06435	COG0513	Belongs to the DEAD box helicase family
B6G06_RS06450	COG0006	proline dipeptidase activity
B6G06_RS06460	COG2239	Acts as a magnesium transporter
B6G06_RS06480	COG4122	O-methyltransferase activity
B6G06_RS06490	COG1611	Belongs to the LOG family
B6G06_RS06495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6G06_RS06500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6G06_RS06500	COG1321	iron dependent repressor
B6G06_RS06510	COG1121	(ABC) transporter
B6G06_RS06515	COG0803	Belongs to the bacterial solute-binding protein 9 family
B6G06_RS06535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B6G06_RS06545	COG0708	Exodeoxyribonuclease III
B6G06_RS06555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6G06_RS06560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6G06_RS06570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6G06_RS06575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6G06_RS06580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6G06_RS06585	COG0254	rRNA binding
B6G06_RS06590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6G06_RS06595	COG0310	cobalt ion transport
B6G06_RS06605	COG1122	ATPase activity
B6G06_RS06615	COG0832	Belongs to the urease beta subunit family
B6G06_RS06620	COG0804	urea catabolic process
B6G06_RS06630	COG0830	nickel cation binding
B6G06_RS06660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B6G06_RS06670	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B6G06_RS06685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B6G06_RS06690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B6G06_RS06695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B6G06_RS06700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B6G06_RS06705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6G06_RS06710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6G06_RS06715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6G06_RS06720	COG0356	it plays a direct role in the translocation of protons across the membrane
B6G06_RS06730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6G06_RS06735	COG0009	L-threonylcarbamoyladenylate synthase
B6G06_RS06745	COG2197	response regulator
B6G06_RS06780	COG0667	Aldo Keto reductase
B6G06_RS06790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6G06_RS06790	COG0519	Catalyzes the synthesis of GMP from XMP
B6G06_RS06810	COG2814	Major facilitator Superfamily
B6G06_RS06815	COG1082	Xylose isomerase domain protein TIM barrel
B6G06_RS06820	COG0673	inositol 2-dehydrogenase activity
B6G06_RS06840	COG3718	enzyme involved in inositol metabolism
B6G06_RS06855	COG2188	Transcriptional regulator
B6G06_RS06860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6G06_RS06865	COG0673	inositol 2-dehydrogenase activity
B6G06_RS06875	COG1609	Transcriptional regulator
B6G06_RS06880	COG0673	inositol 2-dehydrogenase activity
B6G06_RS06885	COG2814	Major facilitator Superfamily
B6G06_RS06890	COG1082	Xylose isomerase domain protein TIM barrel
B6G06_RS06895	COG2814	Major facilitator Superfamily
B6G06_RS06900	COG1609	Transcriptional regulator
B6G06_RS06925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6G06_RS06930	COG0328	RNA-DNA hybrid ribonuclease activity
B6G06_RS06935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6G06_RS06940	COG0516	GMP reductase activity
B6G06_RS06955	COG4152	abc transporter atp-binding protein
B6G06_RS06960	COG2197	response regulator
B6G06_RS06965	COG4585	Histidine kinase
B6G06_RS06975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6G06_RS06985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6G06_RS06990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6G06_RS06995	COG1053	succinate dehydrogenase
B6G06_RS07020	COG0802	atpase or kinase
B6G06_RS07025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6G06_RS07030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6G06_RS07040	COG1072	(Pantothenic acid kinase))
B6G06_RS07045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B6G06_RS07050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B6G06_RS07060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6G06_RS07065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6G06_RS07070	COG0101	tRNA pseudouridine synthase activity
B6G06_RS07085	COG0203	ribosomal protein L17
B6G06_RS07090	COG0202	RNA polymerase activity
B6G06_RS07095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6G06_RS07100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6G06_RS07105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6G06_RS07110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B6G06_RS07120	COG0563	adenylate kinase activity
B6G06_RS07130	COG0200	Binds to the 23S rRNA
B6G06_RS07135	COG1841	ribosomal large subunit assembly
B6G06_RS07140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6G06_RS07150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6G06_RS07155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6G06_RS07160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6G06_RS07165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6G06_RS07170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6G06_RS07175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6G06_RS07185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B6G06_RS07190	COG0255	Belongs to the universal ribosomal protein uL29 family
B6G06_RS07195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B6G06_RS07200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6G06_RS07205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6G06_RS07210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6G06_RS07215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6G06_RS07220	COG0089	rRNA binding
B6G06_RS07230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6G06_RS07235	COG0051	transcription antitermination factor activity, RNA binding
B6G06_RS07265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6G06_RS07270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6G06_RS07275	COG0049	tRNA binding
B6G06_RS07280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B6G06_RS07300	COG0714	Associated with various cellular activities
B6G06_RS07305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6G06_RS07310	COG0085	RNA polymerase activity
B6G06_RS07315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6G06_RS07320	COG1162	GTPase activity
B6G06_RS07350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6G06_RS07370	COG0315	cyclic pyranopterin monophosphate synthase activity
B6G06_RS07380	COG0315	cyclic pyranopterin monophosphate synthase activity
B6G06_RS07380	COG0521	Mo-molybdopterin cofactor biosynthetic process
B6G06_RS07395	COG1140	nitrate reductase beta subunit
B6G06_RS07400	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B6G06_RS07420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6G06_RS07425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6G06_RS07430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6G06_RS07435	COG1120	ATPase activity
B6G06_RS07440	COG1063	alcohol dehydrogenase
B6G06_RS07445	COG2249	NAD(P)H dehydrogenase (quinone) activity
B6G06_RS07450	COG0483	inositol monophosphate 1-phosphatase activity
B6G06_RS07455	COG1968	undecaprenyl-diphosphatase activity
B6G06_RS07460	COG0420	3'-5' exonuclease activity
B6G06_RS07465	COG0419	ATPase involved in DNA repair
B6G06_RS07505	COG0653	protein targeting
B6G06_RS07515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B6G06_RS07525	COG5002	protein histidine kinase activity
B6G06_RS07525	COG5000	phosphorelay sensor kinase activity
B6G06_RS07530	COG0745	RESPONSE REGULATOR receiver
B6G06_RS07550	COG0714	Associated with various cellular activities
B6G06_RS07610	COG4750	Nucleotidyl transferase
B6G06_RS07615	COG0697	spore germination
B6G06_RS07620	COG3475	LICD family
B6G06_RS07630	COG1215	transferase activity, transferring glycosyl groups
B6G06_RS07635	COG3475	LICD family
B6G06_RS07640	COG0438	transferase activity, transferring glycosyl groups
B6G06_RS07650	COG1216	Glycosyl transferase, family 2
B6G06_RS07670	COG2161	toxin-antitoxin pair type II binding
B6G06_RS07675	COG4115	mRNA cleavage
B6G06_RS07680	COG3754	Rhamnan synthesis protein F
B6G06_RS07730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B6G06_RS07755	COG0438	transferase activity, transferring glycosyl groups
B6G06_RS07790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6G06_RS07795	COG0463	Glycosyl transferase, family 2
B6G06_RS07815	COG1316	TRANSCRIPTIONal
B6G06_RS07850	COG0586	Pfam SNARE associated Golgi protein
B6G06_RS07860	COG5002	protein histidine kinase activity
B6G06_RS07875	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6G06_RS07875	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6G06_RS07895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6G06_RS07915	COG1666	GTP binding
B6G06_RS07920	COG0501	Belongs to the peptidase M48B family
B6G06_RS07930	COG1121	(ABC) transporter
B6G06_RS07955	COG0142	geranyltranstransferase activity
B6G06_RS07960	COG1007	ATP synthesis coupled electron transport
B6G06_RS07970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6G06_RS07975	COG0713	ATP synthesis coupled electron transport
B6G06_RS07990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6G06_RS07995	COG1034	ATP synthesis coupled electron transport
B6G06_RS08000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B6G06_RS08010	COG0649	NAD binding
B6G06_RS08015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6G06_RS08020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6G06_RS08030	COG0644	oxidoreductase
B6G06_RS08035	COG2226	methyltransferase
B6G06_RS08045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6G06_RS08050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B6G06_RS08055	COG4948	Mandelate Racemase Muconate Lactonizing
B6G06_RS08060	COG2235	arginine
B6G06_RS08065	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B6G06_RS08070	COG3477	response to acidic pH
B6G06_RS08080	COG1595	DNA-templated transcription, initiation
B6G06_RS08115	COG0574	Belongs to the PEP-utilizing enzyme family
B6G06_RS08115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6G06_RS08125	COG0438	transferase activity, transferring glycosyl groups
B6G06_RS08125	COG0297	glycogen (starch) synthase activity
B6G06_RS08145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B6G06_RS08145	COG1116	anion transmembrane transporter activity
B6G06_RS08165	COG1490	D-aminoacyl-tRNA deacylase activity
B6G06_RS08180	COG3485	protocatechuate 3,4-dioxygenase
B6G06_RS08190	COG0745	RESPONSE REGULATOR receiver
B6G06_RS08215	COG1764	response to oxidative stress
B6G06_RS08220	COG1846	Transcriptional regulator
B6G06_RS08225	COG0513	Belongs to the DEAD box helicase family
B6G06_RS08245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6G06_RS08285	COG1132	(ABC) transporter
B6G06_RS08315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6G06_RS08325	COG2610	gluconate transmembrane transporter activity
B6G06_RS08330	COG2084	Dehydrogenase
B6G06_RS08340	COG2186	Transcriptional regulator
B6G06_RS08355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6G06_RS08355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6G06_RS08360	COG1105	Belongs to the carbohydrate kinase PfkB family
B6G06_RS08365	COG1349	DNA-binding transcription factor activity
B6G06_RS08370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6G06_RS08380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6G06_RS08385	COG0438	transferase activity, transferring glycosyl groups
B6G06_RS08390	COG0047	phosphoribosylformylglycinamidine synthase activity
B6G06_RS08395	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6G06_RS08410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6G06_RS08415	COG0151	Belongs to the GarS family
B6G06_RS08420	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B6G06_RS08435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6G06_RS08460	COG0191	fructose-bisphosphate aldolase activity
B6G06_RS08465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6G06_RS08480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6G06_RS08490	COG4221	oxidoreductase activity
B6G06_RS08500	COG0778	Nitroreductase
B6G06_RS08510	COG2176	DNA-directed DNA polymerase activity
B6G06_RS08525	COG0717	Belongs to the dCTP deaminase family
B6G06_RS08590	COG0714	Associated with various cellular activities
B6G06_RS08605	COG0631	protein serine/threonine phosphatase activity
B6G06_RS08620	COG1051	belongs to the nudix hydrolase family
B6G06_RS08635	COG2860	membrane
B6G06_RS08640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B6G06_RS08645	COG3142	Participates in the control of copper homeostasis
B6G06_RS08665	COG1643	Atp-dependent helicase
B6G06_RS08675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6G06_RS08695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B6G06_RS08720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B6G06_RS08730	COG0588	phosphoglycerate mutase activity
B6G06_RS08745	COG1113	amino acid transport
B6G06_RS08750	COG0252	asparaginase activity
B6G06_RS08765	COG0470	DNA polymerase III
B6G06_RS08775	COG2235	arginine
B6G06_RS08780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6G06_RS08785	COG0549	Belongs to the carbamate kinase family
B6G06_RS08810	COG1754	DNA topoisomerase type I activity
B6G06_RS08810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6G06_RS08825	COG0745	RESPONSE REGULATOR receiver
B6G06_RS08830	COG2205	protein histidine kinase activity
B6G06_RS08855	COG0450	alkyl hydroperoxide reductase
B6G06_RS08870	COG1011	Hydrolase
B6G06_RS08905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B6G06_RS08915	COG0596	Alpha beta hydrolase
B6G06_RS08935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6G06_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
B6G06_RS08975	COG4974	Belongs to the 'phage' integrase family
B6G06_RS09085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6G06_RS09140	COG1674	ftsk spoiiie
B6G06_RS09225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6G06_RS09270	COG0758	DNA mediated transformation
B6G06_RS09295	COG1674	ftsk spoiiie
B6G06_RS09310	COG0791	NLP P60 protein
B6G06_RS09310	COG0741	lytic transglycosylase activity
B6G06_RS09395	COG1597	lipid kinase activity
B6G06_RS09410	COG1918	ferrous iron import across plasma membrane
B6G06_RS09410	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B6G06_RS09425	COG1051	belongs to the nudix hydrolase family
B6G06_RS09430	COG0366	Alpha amylase catalytic
B6G06_RS09445	COG1674	ftsk spoiiie
B6G06_RS09525	COG0783	Belongs to the Dps family
B6G06_RS09530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6G06_RS09535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6G06_RS09535	COG3253	May function as heme-dependent peroxidase
B6G06_RS09540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6G06_RS09545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B6G06_RS09550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B6G06_RS09560	COG0181	hydroxymethylbilane synthase activity
B6G06_RS09570	COG0113	porphobilinogen synthase activity
B6G06_RS09575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6G06_RS09590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B6G06_RS09640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6G06_RS09645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6G06_RS09645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6G06_RS09660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6G06_RS09665	COG1780	Probably involved in ribonucleotide reductase function
B6G06_RS09690	COG0366	Alpha amylase catalytic
B6G06_RS09695	COG3550	peptidyl-serine autophosphorylation
B6G06_RS09730	COG0628	permease
B6G06_RS09740	COG1854	S-ribosylhomocysteine lyase activity
B6G06_RS09750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B6G06_RS09755	COG0351	phosphomethylpyrimidine kinase
B6G06_RS09765	COG0569	domain protein
B6G06_RS09765	COG2985	domain, Protein
B6G06_RS09790	COG1113	amino acid transport
B6G06_RS09800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6G06_RS09805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6G06_RS09815	COG1940	carbohydrate kinase activity
B6G06_RS09825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6G06_RS09830	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6G06_RS09835	COG1120	ATPase activity
B6G06_RS09845	COG0305	Participates in initiation and elongation during chromosome replication
B6G06_RS09850	COG0534	Mate efflux family protein
B6G06_RS09855	COG0359	binds to the 23S rRNA
B6G06_RS09860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6G06_RS09865	COG0629	single-stranded DNA binding
B6G06_RS09870	COG0360	Binds together with S18 to 16S ribosomal RNA
B6G06_RS09875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6G06_RS09885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6G06_RS09890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B6G06_RS09905	COG0617	tRNA 3'-terminal CCA addition
B6G06_RS09925	COG0492	ferredoxin-NADP+ reductase activity
B6G06_RS09930	COG3118	belongs to the thioredoxin family
B6G06_RS09940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6G06_RS09945	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6G06_RS09960	COG0357	Ribosomal RNA small subunit methyltransferase G
B6G06_RS09970	COG0706	membrane insertase activity
B6G06_RS09975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B6G06_RS09980	COG0594	ribonuclease P activity
B6G06_RS09985	COG0230	Belongs to the bacterial ribosomal protein bL34 family